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The Future of Genomic Medicine II the Neurosciences Institute Auditorium San Diego, California

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The Future of Genomic Medicine II the Neurosciences Institute Auditorium San Diego, California SCRIPPS GENOMIC MEDICINE A COLL ABoraTion OF S cripps H ea LT H and T H E S C R I P P S R E S E A RC H I NS T I T U T E TheThe Future Future of of Genomic Genomic MedicineMedicine II II in collaboration with: Friday, February 27 and Saturday, February 28, 2009 The Neurosciences Institute Auditorium San Diego, California Dear Colleague, Scripps Genomic Medicine A collaboration between Scripps Health and The Scripps Research Institute We invite you to a special day and a half program on a Friday, February 27 and Saturday, February 28, 2009 in beautiful La Jolla, California. Once again, Scripps Genomic Medicine, an initiative of Scripps Health in collaboration this year’s program will be held at the Neurosciences Institute Auditorium on The with The Scripps Research Institute, supports basic research and clinical pro- Scripps Research Institute campus. grams focused on defining the genes that underlie susceptibility to disease, As you will see in the enclosed program, we are inviting a dynamic group of and will take these findings into drug discovery programs and ultimately into speakers who will cover a wide range of topics. The Friday afternoon session clinical trials. The program’s work involves genotyping tens of thousands of will focus on Technology Breakthroughs and Challenges whereas the Saturday individuals of diverse ancestry in an attempt to identify and define genes re- session will feature a wide variety of topics along with keynote speakers. Our goal is to continue to examine the salient progress and challenges in the field of sponsible for major disease and the underpinnings of health. The identification genomics with concise, 20-minute presentations, allowing ample time for interac- of these genes will lead to drug discovery and gene-specific clinical trials. The tive panel and participant discussions following each topic series. rich diversity of the San Diego population – the primary patient base of the We look forward to your participation, Scripps program – provides unparalleled opportunities for this research. For more information on Scripps Health, visit www.scripps.org. Eric J. Topol, M.D., and Robert L. Strausberg, Ph.D. For more information on The Scripps Research Institute, visit Course Co-Directors www.scripps.edu. Educational Objectives The J. Craig Venter Institute • Demonstrate the unmet needs of medicine today with respect to more targeted, The J. Craig Venter Institute (JCVI) is a not-for-profit research institute dedicated individualized prevention and treatments. to the advancement of the science of genomics; the understanding of its • Discuss the opportunities of the genome, proteome, metabolome discovery implications for society; and the communication of those results to the scientific to change medical practice as it exists today. community, the public, and policymakers. Founded by J. Craig Venter, Ph.D., • Assess how changes and advances in technology are rapidly ushering in a whole the Institute, through its two divisions—The Institute for Genomic Research array of new pathways for individualized medicine of the future. (TIGR) and The Center for the Advancement of Genomics (TCAG) is home to • Explore specific strategies in cancer, cardiovascular and pharmacogenomic more than 500 scientists and staff with expertise in human and evolutionary futuristic interventions. biology, genetics, bioinformatics/informatics, high-throughput DNA sequenc- ing, information technology, functional genomics, and genomic and environ- Who Should Attend? mental policy research. • Human geneticists For more information on the J. Craig Venter Institute visit, www.venterinstitute.org. • Genomic scientists • Health care professionals of all disciplines interested in the future of medicine, especially with respect to individualized therapies. Faculty COURSE CO-DIREctORS KEYNOTE SPEAKER Hakon Hakonarson, M.D., Ph.D. Bing Ren, Ph.D. Eric J. Topol, M.D. Craig Venter, Ph.D. Director, Center for Applied Genomics Associate Professor, Director, Scripps Translational Chairman and President, Department of Pediatrics & Ludwig Institute for Cancer Research Science Institute (STSI) The J. Craig Venter Institute Division of Genetics Department of Cellular and Chief Academic Officer, Scripps Health Rockville, Maryland The Joseph Stokes Jr. Research Institute Molecular Medicine Senior Consultant, The Children’s Hospital of Philadelphia University of California, San Diego Division of Cardiology, Scripps Clinic University of Pennsylvania La Jolla, California Dean, School of Medicine GUEst FacULTY School of Medicine Scripps Clinic & The Scripps David B. Allison, Ph.D. Stephen W. Scherer, Ph.D., FRSC Philadelphia, Pennsylvania Research Institute Head, Section of Statistical Genetics Senior Scientist, La Jolla, California University of Alabama at Birmingham Eran Halperin, Ph.D. Department of Genetics & Robert L. Strausberg, Ph.D. Birmingham, Alabama Director of Bioinformatics, Genomic Biology Navigenics Incorporated The Hospital for Sick Children Deputy Director, Vineet Bafna, Ph.D. The J. Craig Venter Institute Berkeley, California Professor, Department of Molecular Associate Professor, Computer Science Rockville, Maryland Principal Investigator, Internal and Medical Genetics University of California, San Diego Computer Science Institute The Center for Applied Genomics, La Jolla, California ORGaniZinG COMMittEE Redwood Shores, California Hospital for Sick Children Kelly Frazer, Ph.D. David R. Bentley, Ph.D. University of Toronto, Ontario, Canada Jeffery W. Kelly, Ph.D. Director, Genomic Biology Vice President and Chief Scientist, Richard Simon, Ph.D. Scripps Genomic Medicine Illumina, Inc. Lita Annenberg Hazen Scripps Health and San Diego, California Professor of Chemistry, Chief, Biometric Research Branch The Scripps Research Institute Department of Chemistry & The National Cancer Institute La Jolla, California Joseph R. Ecker, Ph.D. Skaggs Institute of Chemical Biology Rockville, Maryland Professor, Plant Biology Laboratory Dean, Graduate & Postgraduate Studies Samuel Levy, Ph.D. The Salk Institute for Biological Studies The Scripps Research Institute Stephen Turner, Ph.D. Director, Human Genomics Founder and Chief Technology Officer, San Diego, California La Jolla, California The J. Craig Venter Institute Pacific Biosciences Rockville, Maryland Richard A. Gibbs, Ph.D. Patrice M. Milos, Ph.D. Menlo Park, California Wofford Cain Professor, Sarah S. Murray, Ph.D. Vice President and Chief Scientific Officer, Department of Molecular and Helicos BioSciences Corporation John N. Weinstein, M.D., Ph.D. Director, Genetics Professor and Chair, Bioinformatics & Scripps Genomic Medicine Human Genetics Cambridge, Massachusetts Scripps Health and Director, Human Genome Computational Biology The Scripps Research Institute Sequencing Center, Steven G. Potkin, M.D. University of Texas La Jolla, California Baylor College of Medicine Director of Clinical Research and M.D. Anderson Cancer Center Houston, Texas Director of the Brain Imaging Center, Houston, Texas Nicholas J. Schork, Ph.D. Department of Psychiatry and Director of Research, Peter K. Gregersen, M.D. Human Behavior Scripps Genomic Medicine Director, Robert S. Boas Center for Director of Biostatistics and Bioinformatics, University of California, Irvine Genomics and Human Genetics Irvine, California The Scripps Translational Science Institute Feinstein Institute for Medical Research Professor, Molecular and North Shore LIJ Health System Experimental Medicine Scripps Health and Professor of Medicine and Pathology, The Scripps Research Institute NYU School of Medicine La Jolla, California Manhasset, New York Program – Friday, February 27 and Saturday, February 28, 2009 FRidaY, FEBRUARY 27, 2009 SATURDAY, FEBRUARY 28, 2009 – Morning Session 12:00 p.m. Registration, Lunch and View Exhibits 7:30 a.m. Sign In, Breakfast & View Exhibits 12:45 p.m. Welcome and Educational Overview 8:00 a.m. Welcome and Educational Overview Eric J. Topol, M.D. TECHNOLOGY BREAKTHROUGHS AND CHALLENGES Moderators: Robert L. Strausberg, Ph.D. and Kelly Frazer, Ph.D. 8:15 a.m. Keynote: Transforming Genomics to Better Medicine 1:00 p.m. Sequencing 100 or 10,000 Human Genomes Craig Venter, Ph.D. Samuel Levy, Ph.D. Advances IN UnderstandING CHRONIC ILLNESS: 1:25 p.m. Panel Discussion/Q&A WHERE DO WE Stand? What NEXT? 1:30 p.m. Next Generation Sequencing Moderators: Eric J. Topol, M.D. and Brad Patay, M.D. Richard A. Gibbs, Ph.D.; Stephen Turner, Ph.D.; 9:00 a.m. Cardiovascular Diseases Patrice M. Milos, Ph.D.; David R. Bentley, Ph.D. Eric J. Topol, M.D. 2:30 p.m. Panel Discussion/Q&A 9:20 a.m. Cancer 2:50 p.m. Break and View Exhibits Robert L. Strausberg, Ph.D. 3:20 p.m. Bioinformatic Challenges in 9:40 a.m. Immunologic Diseases (Crohn’s, RA, AMD) High Throughput Sequencing Peter K. Gregersen, M.D. Vineet Bafna, Ph.D. 10:00 a.m. Neurodegenerative Diseases 3:45 p.m. Analytic Challenges in Steven G. Potkin, M.D. High Throughput Sequencing 10:20 a.m. Metabolic Diseases (DM, Obesity) Nicholas J. Schork, Ph.D. David B. Allison, Ph.D. 4:10 p.m. Panel Discussion/Q&A 10:40 a.m.. Pediatric Diseases Hakon Hakonarson, M.D., Ph.D. 4:30 – 6:00 p.m. – Adjourn and Shuttle to Welcome Reception 11:00 a.m. Disease Panel Discussion/Q&A Torrey Pines Court – New home of Scripps Genomic Medicine 11:30 a.m. 2nd Annual Scripps Genomic Medicine Award Presentation 11:45 a.m. Lunch and View Exhibits Directions SATURDAY, FEBRUARY 28, 2009 – 3:40 p.m. Companion Therapeutics The Neurosciences Institute Auditorium Afternoon Session John N. Weinstein, M.D., Ph.D. 10640 John Jay Hopkins Dr. HOLES IN OUR KNOWLEDGE BASE 4:00 p.m. Targeted Therapies San Diego, California Moderators: Sarah S. Murray, Ph.D. and Jeffery W. Kelly, Ph.D. 92121 Samuel Levy, Ph.D. 4:20 p.m. Clinical Trials of Individualized 12:30 p.m. • From Interstate 5, exit at Genesee Avenue Genome Wide Association Studies Medicine Sarah S. Murray, Ph.D. and go west for about 0.8 mile to the Richard Simon, Ph.D. second stoplight (not counting any at the 12:50 p.m. Rare Variants 4:40 p.m. I-5 exit). Kelly Frazer, Ph.D. The Next Frontier in Medicine Panel Discussion/Q&A • Turn right (north) onto John Jay Hopkins Drive.
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