SCRIPPS GENOMIC MEDICINE A Coll aboration of S cripps H ea lt h and T H E S C R I P P S R E S E A RC H I NS T I T U T E

TheThe Future Future of of Genomic Genomic MedicineMedicine II II

in collaboration with: Friday, February 27 and Saturday, February 28, 2009 The Neurosciences Institute Auditorium San Diego, California Dear Colleague, Scripps Genomic Medicine A collaboration between Scripps Health and The Scripps Research Institute We invite you to a special day and a half program on a Friday, February 27 and Saturday, February 28, 2009 in beautiful La Jolla, California. Once again, Scripps Genomic Medicine, an initiative of Scripps Health in collaboration this year’s program will be held at the Neurosciences Institute Auditorium on The with The Scripps Research Institute, supports basic research and clinical pro- Scripps Research Institute campus. grams focused on defining the genes that underlie susceptibility to disease, As you will see in the enclosed program, we are inviting a dynamic group of and will take these findings into drug discovery programs and ultimately into speakers who will cover a wide range of topics. The Friday afternoon session clinical trials. The program’s work involves genotyping tens of thousands of will focus on Technology Breakthroughs and Challenges whereas the Saturday individuals of diverse ancestry in an attempt to identify and define genes re- session will feature a wide variety of topics along with keynote speakers. Our goal is to continue to examine the salient progress and challenges in the field of sponsible for major disease and the underpinnings of health. The identification genomics with concise, 20-minute presentations, allowing ample time for interac- of these genes will lead to drug discovery and gene-specific clinical trials. The tive panel and participant discussions following each topic series. rich diversity of the San Diego population – the primary patient base of the We look forward to your participation, Scripps program – provides unparalleled opportunities for this research.

For more information on Scripps Health, visit www.scripps.org.

Eric J. Topol, M.D., and Robert L. Strausberg, Ph.D. For more information on The Scripps Research Institute, visit Course Co-Directors www.scripps.edu.

Educational Objectives The J. Craig Venter Institute • Demonstrate the unmet needs of medicine today with respect to more targeted, The J. Craig Venter Institute (JCVI) is a not-for-profit research institute dedicated individualized prevention and treatments. to the advancement of the science of genomics; the understanding of its • Discuss the opportunities of the genome, proteome, metabolome discovery implications for society; and the communication of those results to the scientific to change medical practice as it exists today. community, the public, and policymakers. Founded by J. Craig Venter, Ph.D., • Assess how changes and advances in technology are rapidly ushering in a whole the Institute, through its two divisions—The Institute for Genomic Research array of new pathways for individualized medicine of the future. (TIGR) and The Center for the Advancement of Genomics (TCAG) is home to • Explore specific strategies in cancer, cardiovascular and pharmacogenomic more than 500 scientists and staff with expertise in human and evolutionary futuristic interventions. biology, genetics, bioinformatics/informatics, high-throughput DNA sequenc- ing, information technology, functional genomics, and genomic and environ- Who Should Attend? mental policy research. • Human geneticists For more information on the J. Craig Venter Institute visit, www.venterinstitute.org. • Genomic scientists • Health care professionals of all disciplines interested in the future of medicine, especially with respect to individualized therapies. Faculty

Course Co-Directors keynote speaker Hakon Hakonarson, M.D., Ph.D. Bing Ren, Ph.D. Eric J. Topol, M.D. Craig Venter, Ph.D. Director, Center for Applied Genomics Associate Professor, Director, Scripps Translational Chairman and President, Department of Pediatrics & Ludwig Institute for Cancer Research Science Institute (STSI) The J. Craig Venter Institute Division of Genetics Department of Cellular and Chief Academic Officer, Scripps Health Rockville, Maryland The Joseph Stokes Jr. Research Institute Molecular Medicine Senior Consultant, The Children’s Hospital of Philadelphia University of California, San Diego Division of Cardiology, Scripps Clinic University of Pennsylvania La Jolla, California Dean, School of Medicine Guest Faculty School of Medicine Scripps Clinic & The Scripps David B. Allison, Ph.D. Stephen W. Scherer, Ph.D., FRSC Philadelphia, Pennsylvania Research Institute Head, Section of Statistical Genetics Senior Scientist, La Jolla, California University of Alabama at Birmingham Eran Halperin, Ph.D. Department of Genetics & Robert L. Strausberg, Ph.D. Birmingham, Alabama Director of Bioinformatics, Genomic Biology Navigenics Incorporated The Hospital for Sick Children Deputy Director, Vineet Bafna, Ph.D. The J. Craig Venter Institute Berkeley, California Professor, Department of Molecular Associate Professor, Computer Science Rockville, Maryland Principal Investigator, Internal and Medical Genetics University of California, San Diego Computer Science Institute The Center for Applied Genomics, La Jolla, California Organizing Committee Redwood Shores, California Hospital for Sick Children Kelly Frazer, Ph.D. David R. Bentley, Ph.D. University of Toronto, Ontario, Canada Jeffery W. Kelly, Ph.D. Director, Genomic Biology Vice President and Chief Scientist, Richard Simon, Ph.D. Scripps Genomic Medicine Illumina, Inc. Lita Annenberg Hazen Scripps Health and San Diego, California Professor of Chemistry, Chief, Biometric Research Branch The Scripps Research Institute Department of Chemistry & The National Cancer Institute La Jolla, California Joseph R. Ecker, Ph.D. Skaggs Institute of Chemical Biology Rockville, Maryland Professor, Plant Biology Laboratory Dean, Graduate & Postgraduate Studies Samuel Levy, Ph.D. The Salk Institute for Biological Studies The Scripps Research Institute Stephen Turner, Ph.D. Director, Human Genomics Founder and Chief Technology Officer, San Diego, California La Jolla, California The J. Craig Venter Institute Pacific Biosciences Rockville, Maryland Richard A. Gibbs, Ph.D. Patrice M. Milos, Ph.D. Menlo Park, California Wofford Cain Professor, Sarah S. Murray, Ph.D. Vice President and Chief Scientific Officer, Department of Molecular and Helicos BioSciences Corporation John N. Weinstein, M.D., Ph.D. Director, Genetics Professor and Chair, Bioinformatics & Scripps Genomic Medicine Human Genetics Cambridge, Massachusetts Scripps Health and Director, Human Genome Computational Biology The Scripps Research Institute Sequencing Center, Steven G. Potkin, M.D. University of Texas La Jolla, California Baylor College of Medicine Director of Clinical Research and M.D. Anderson Cancer Center Houston, Texas Director of the Brain Imaging Center, Houston, Texas Nicholas J. Schork, Ph.D. Department of Psychiatry and Director of Research, Peter K. Gregersen, M.D. Human Behavior Scripps Genomic Medicine Director, Robert S. Boas Center for Director of Biostatistics and Bioinformatics, University of California, Irvine Genomics and Human Genetics Irvine, California The Scripps Translational Science Institute Feinstein Institute for Medical Research Professor, Molecular and North Shore LIJ Health System Experimental Medicine Scripps Health and Professor of Medicine and Pathology, The Scripps Research Institute NYU School of Medicine La Jolla, California Manhasset, New York Program – Friday, February 27 and Saturday, February 28, 2009

Friday, February 27, 2009 Saturday, February 28, 2009 – Morning Session 12:00 p.m. Registration, Lunch and View Exhibits 7:30 a.m. Sign In, Breakfast & View Exhibits 12:45 p.m. Welcome and Educational Overview 8:00 a.m. Welcome and Educational Overview Eric J. Topol, M.D. Technology Breakthroughs and Challenges Moderators: Robert L. Strausberg, Ph.D. and Kelly Frazer, Ph.D. 8:15 a.m. Keynote: Transforming Genomics to Better Medicine 1:00 p.m. Sequencing 100 or 10,000 Human Genomes Craig Venter, Ph.D. Samuel Levy, Ph.D. Advances in Understanding Chronic Illness: 1:25 p.m. Panel Discussion/Q&A Where Do We Stand? What Next? 1:30 p.m. Next Generation Sequencing Moderators: Eric J. Topol, M.D. and Brad Patay, M.D. Richard A. Gibbs, Ph.D.; Stephen Turner, Ph.D.; 9:00 a.m. Cardiovascular Diseases Patrice M. Milos, Ph.D.; David R. Bentley, Ph.D. Eric J. Topol, M.D. 2:30 p.m. Panel Discussion/Q&A 9:20 a.m. Cancer 2:50 p.m. Break and View Exhibits Robert L. Strausberg, Ph.D. 3:20 p.m. Bioinformatic Challenges in 9:40 a.m. immunologic Diseases (Crohn’s, RA, AMD) High Throughput Sequencing Peter K. Gregersen, M.D. Vineet Bafna, Ph.D. 10:00 a.m. Neurodegenerative Diseases 3:45 p.m. Analytic Challenges in Steven G. Potkin, M.D. High Throughput Sequencing 10:20 a.m. Metabolic Diseases (DM, Obesity) Nicholas J. Schork, Ph.D. David B. Allison, Ph.D. 4:10 p.m. Panel Discussion/Q&A 10:40 a.m.. Pediatric Diseases Hakon Hakonarson, M.D., Ph.D. 4:30 – 6:00 p.m. – Adjourn and Shuttle to Welcome Reception 11:00 a.m. Disease Panel Discussion/Q&A Torrey Pines Court – New home of Scripps Genomic Medicine 11:30 a.m. 2nd Annual Scripps Genomic Medicine Award Presentation 11:45 a.m. Lunch and View Exhibits Directions

Saturday, February 28, 2009 – 3:40 p.m. Companion Therapeutics The Neurosciences Institute Auditorium Afternoon Session John N. Weinstein, M.D., Ph.D. 10640 John Jay Hopkins Dr. Holes in our Knowledge Base 4:00 p.m. Targeted Therapies San Diego, California Moderators: Sarah S. Murray, Ph.D. and Jeffery W. Kelly, Ph.D. 92121 Samuel Levy, Ph.D. 4:20 p.m. Clinical Trials of Individualized 12:30 p.m. • From Interstate 5, exit at Genesee Avenue Genome Wide Association Studies Medicine Sarah S. Murray, Ph.D. and go west for about 0.8 mile to the Richard Simon, Ph.D. second stoplight (not counting any at the 12:50 p.m. Rare Variants 4:40 p.m. I-5 exit). Kelly Frazer, Ph.D. The Next Frontier in Medicine Panel Discussion/Q&A • Turn right (north) onto John Jay Hopkins Drive. 1:10 p.m. Structural Variation 5:00 p.m. Adjourn Stephen W. Scherer, Ph.D., FRSC • Turn left at the second opportunity (about 0.1 1:30 p.m. Regulatory Elements (miRNA, mile) into the Institute’s driveway. Enhancers, etc.) Bing Ren, Ph.D. • Turn left into the gated parking lot.

1:50 p.m. Epigenomics • Walk North and follow the signs leading to Joseph R. Ecker, Ph.D. the Auditorium.

2:10 p.m. Holes in our Knowledge Base Torrey Pines Road Panel Discussion/Q&A 5

2:40 p.m. Break & View Exhibits Hilton Torrey N Pines Hotel l Scripps John Jay Hopkins Dr The Next Frontier in Medicine Clinic The Neurosciences Scripps Pacific Institute Ocean Research Moderators: Robert L. Strausberg, Ph.D. and Institute Genesee Avenue 805 Salk Institute Nicholas J. Schork, Ph.D. UCSD

La Jolla Village Drive Miramar Road Gillman Drive 3:00 p.m. Personal Genomics Genesee Avenue

Eric J. Topol, M.D.

Ardath Rd 52 3:20 p.m. Diagnostics/Predictive Medicine Torrey Pines Road Eran Halperin, Ph.D. 5 Conference Location Recommended Lodging

San Diego, California Recommended Lodging Exhibit and Support Beautiful San Diego is California’s second the hilton la jolla torrey pines Opportunities largest city where blue skies keep watch Located only one mile from the confer- For information on exhibit and support opportunities dur- over 70 miles of beaches and an almost ence venue, this beautiful hotel overlooks ing this and many other Scripps educational conferences, perfect climate provides an idyllic setting for the internationally famous Torrey Pines please contact Scripps Conference Services & CME at: partaking in the many business and leisure Golf Course, home to the PGA Buick Scripps Conference Services & CME at: activities. Nestled on the northern edge of Invitational and the 2008 US Open Golf Web San Diego is La Jolla. La Jolla means “The www.scripps.org/conferenceservices Tournament. With the Pacific Ocean Jewel” in Spanish and it is the jewel of San Email [email protected] as a backdrop, all rooms command a Diego. Located just 15 minutes from down- Phone (858)652-5400 spectacular view of either the ocean and town, it is known throughout the world for championship golf course, or a meticu- its beautiful beaches and year-round tem- lously tended, lush garden. perate weather. La Jolla is an exquisite Refund and Cancellation Policy combination of a southern European resort The course tuition is refundable, minus a $40 processing fee, if your Please make your own hotel reservations atmosphere and Southern California fun. In cancellation is received in writing no later than Friday, February and request the Scripps rate of $199 20, 2009. Attendee substitutions are allowed, but notification addition to fine restaurants, it is (plus tax, based on availability). must be made in writing by Friday, February 20, 2009. After this unique in that it maintains its quaint vil- date, under no circumstances will refunds, credits, or substitutions lage atmosphere within a sophisti- The Hilton La Jolla Torrey Pines Hotel be granted. No refunds or credits will be given to “no shows.” cated cosmopolitan environment 10950 North Torrey Pines Road Scripps reserves the right to cancel this conference, in which case a full refund of your registration fee will be provided. We are offering a varied selection of hotels, shop- La Jolla, California 92037 unable to refund any travel costs (flight, hotel, etc.) in the case of ping, dining, events and attractions. Fur- Reservations: (800) HILTONS (445-8667) Scripps cancellation. thermore, San Diego is the model confer- Hotel Direct: (858) 558-1500 ence location as a city leading the nation Fax: (858) 450-4584 in biomedical, high-tech and telecommuni- Recording and Photography Clause cation industries. Scripps reserves exclusive rights to record (audio and video) and/or photograph all conference proceedings for use in www.sandiego.org marketing materials, presentations and course content sales. www.lajolla.com Friday, February 27 and Saturday, February 28, 2009 The Future of Genomic Medicine II The Neurosciences Institute Auditorium San Diego, California

Registration Fee: $80 Registration Complimentary registration for all Students, Residents and Fellows (Please enclose proof of status when registering.) F i r st na m e , m idd l e I nitia l , l A S T N a m e d e g r e e ( m d , p h d , e tc ) Registration includes course tuition, syllabus, breakfast, lunch and refreshment breaks. s p e cia l t y h o s p ita l / affi l iati o n Note: Pre-registration will be accepted through Tuesday, February 24, 2009. After this date, registrations will only be accepted on-site and S t r e e t A dd r e ss will incur an additional $15 fee.

C it y / S tat e / p r o v inc e / z i p c o d e / c o u nt r y To Register Online www.scripps.org/conferenceservices o ffic e T e l e p h o n e F a x Fax (858) 652-5565 Phone (858) 652-5400 e m ai l Mail Scripps Conference Services & CME Genomic Medicine Conference Payment method 11025 North Torrey Pines Rd. Suite 200, Mailstop: SCRC 200 Check Please make payable to Scripps La Jolla, California 92037 Visa MasterCard Amex Discover If paying by credit card, please complete the information below. Questions? Contact Scripps Conference Services & CME at: Phone (858) 652-5400 C r e di t C a r d n u m b e r E x p i r ati o n D at e s e c u r it y c o d e n u m b e r Email [email protected]

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Office Use Only: Date Received Amount Check No. / Approval CD Confirmation Sent Initials SCRIPPS GENOMIC MEDICINE A Collaboration of Scripps Health and THE SCRIPPS RESEARCH INSTITUTE Nonprofit Org. U.S. Postage Conference Services & CME PA I D 11025 North Torrey Pines Road, Suite 200 Permit No. 1981 La Jolla, California 92037 San Diego, CA 92138

The Future of Genomic Medicine II

Friday, February 27 and Saturday, February 28, 2009 in collaboration with: The Neurosciences Institute Auditorium San Diego, California

Join us!