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Tissue Engineering, Regenerative & Precision Medicine Andrew Sumagaysay Ramos, J Tissue Sci Eng 2016, 7:3(Suppl) conferenceseries.com http://dx.doi.org/10.4172/2157-7552.C1.031 Global Congress on Tissue Engineering, Regenerative & Precision Medicine December 1-2, 2016 | San Antonio, USA In vitro development of a vascularized full thickness skin equivalent model Andrew Sumagaysay Ramos University of Colorado Anschutz Medical Campus, USA Syracuse University, USA iven the steadily increasing aging population, the study and care of non-healing wounds in the elderly, caused by Gaging itself or age-associated health conditions (e.g., diabetes or cardiovascular disorders) have become priority topics for researchers and clinicians. Skin autografting is considered to be the optimal approach to achieve complete healing of chronic wounds. As a result, in vitro skin bioengineering has been explored to develop full thickness skin equivalents for transplantation. However, currently available in vitro developed skin equivalents perform poorly during engraftment due to the lack of proper vasculature, often leading to the premature death of grafted tissue. Through advances in skin tissue engineering and induced pluripotent stem cell (iPSC) research, the quality and complexity of skin bioengineered equivalents may be significantly improved by inducing vasculature formation. Given the lack of and difficulty of harvesting available endothelial cells from patients in need of vascularized grafts, attaining endothelial cells from iPSCs has proven to be of recent research interest. In this study, we examined and optimized an approach to derive endothelial cells from iPSCs and determined the ‘proof of concept’ of a more complex, life-like 3D, full thickness skin model through the co-culturing of human fibroblasts and endothelial cells with keratinocytes. Biography Andrew Sumagaysay Ramos is currently a senior undergraduate studying Bioengineering at Syracuse University, USA. He has developed a passion for academic research, after having research experiences in protein nanopores, drug delivery, scaffold engineering, tissue engineering and pluripotent stem cells. He was a summer Research Fellow with the Gates Center for Regenerative Medicine and Stem Cell Biology, under the mentorship of Dr. Ganna Bilousova, conducting research in skin tissue engineering and induced pluripotent stem cells. At Syracuse University, he has participated in research under the guidance of Dr. Pranav Soman, specifically in gelatin methacrylate, its application for bone tissue engineering. [email protected] J Tissue Sci Eng Volume 7, Issue 3(Suppl) ISSN: 2157-7552 JTSE, an open access journal Regenerative & Precision Medicine 2016 December 1-2, 2016 Page 48 Sharareh Ghaziof et al., J Tissue Sci Eng 2016, 7:3(Suppl) conferenceseries.com http://dx.doi.org/10.4172/2157-7552.C1.031 Global Congress on Tissue Engineering, Regenerative & Precision Medicine December 1-2, 2016 | San Antonio, USA New conductive nanocomposite scaffold coated with fibrin glue for myocardial tissue engineering Sharareh Ghaziof and Mehdi Mehdikhani-Nahrkhalaji Islamic Azad University, Iran University of Isfahan, Iran eart disease is the number one cause of death in industrialized nations. Myocardial infarction (MI) and heart failure Hresemble the most prevalent pathologies. Lost cardiomyocytes are replaced by scar tissue resulting in reduced cardiac function causing high morbidity and mortality. One possible solution to this problem is cardiac tissue engineering. Cardiac tissue engineering aims at providing advanced in vitro models and disease modeling as well as heart muscle tissue for myocardial regeneration. Here, we present nanocomposite scaffolds composed of Polycaprolactone (PCL)/Multi Wall Carbon Nanotubes (MWCNTs) with fibrin glue coating (FG) prepared via solvent casting and freeze drying (SC/FD) technique. Characterization techniques such as Fourier transform infrared microscopy (FT-IR), Scanning electron microscopy (SEM), Transmission electron microscopy (TEM) and X-ray diffraction (XRD) were performed. Furthermore, mechanical properties and electrical conductivity of the PCL and nanocomposite scaffolds with and without FG coating were determined. The results revealed that the scaffolds contained sufficient porosity with highly interconnected pore morphology. Addition of multi wall carbon nanotubes in the PCL matrix improved conductivity and also elastic modulus of the prepared scaffolds. Multi Wall carbon nanotubes were used as doping material to develop highly conductive nanocomposite scaffolds. Desired distribution of MWCNT with a few agglomerates was observed in the nanocomposite scaffolds by SEM. The FG coating was homogenous across the entire substrate and allowed the pore structure remain open in the constructs. In conclusion, the electrically conductive and nanofibrous network formed by 1% MWCNTs within a porous PCL scaffold and coated with FG could be used as an appropriate construct for myocardium regeneration. Biography Sharareh Ghaziof has completed his PhD in Biomaterials from Isfahan University of Technology, Iran. He is an Academic Member at the Department of Biomedical Engineering, Faculty of Engineering, University of Isfahan, Iran. He has published several papers in reputed journals. [email protected] Notes: J Tissue Sci Eng Volume 7, Issue 3(Suppl) ISSN: 2157-7552 JTSE, an open access journal Regenerative & Precision Medicine 2016 December 1-2, 2016 Page 49 J Tissue Sci Eng 2016, 7:3(Suppl) conferenceseries.com http://dx.doi.org/10.4172/2157-7552.C1.031 Global Congress on Tissue Engineering, Regenerative & Precision Medicine December 1-2, 2016 | San Antonio, USA From discovering calcium paradox to Ca2+/cAMP interaction: Impact in human health and disease Leandro Bueno Bergantin and Afonso Caricati-Neto Federal University of São Paulo, Brazil he hypothesis of the so-called calcium paradox phenomenon in the sympathetic neurotransmission has its origin in Texperiments done in models of neurotransmission since 1970’s. Historically, calcium paradox originated several clinical studies reporting that acute and chronic administration of L-type Ca2+ Channel Blockers (CCBs), drugs largely used for antihypertensive therapy such as verapamil and nifedipine produces reduction in peripheral vascular resistance and arterial pressure, associated with a paradoxical sympathetic hyperactivity. Despite this sympathetic hyperactivity has been initially attributed to adjust reflex of arterial pressure, the cellular and molecular mechanisms involved in this paradoxical effect of the L-type CCBs remained unclear for four decades. Also, experimental studies using isolated tissues richly innervated by sympathetic nerves showed that neurogenic responses were completely inhibited by L-type CCBs in high concentrations but paradoxically potentiated in low concentrations, characterized as a calcium paradox phenomenon. We discovered in 2013 that this paradoxical increase in sympathetic activity produced by L-type CCBs is due to Ca2+/cAMP interaction. Then, the pharmacological manipulation of this interaction could represent a potential cardiovascular risk for hypertensive patients due to increase of sympathetic hyperactivity. In contrast, this pharmacological manipulation could be a new therapeutic strategy for increasing neurotransmission in psychiatric disorders such as depression and producing neuroprotection in the neurodegenerative diseases such as Alzheimer’s and Parkinson’s diseases. [email protected] Moving forwards towards personalized medicine in lysosomal disorders Andrés D Klein Telethon Institute of Genetics and Medicine, Italy nderstanding phenotypic variability in rare genetic diseases, such as Gaucher disease (GD), is challenging because it Uis hard to recruit large cohorts of patients with different symptoms to perform association studies. To overcome this problem GD was chemically induced in 15 inbred mouse strains because they SNPs profile is known, followed by GWAS. GD- induced strains mimicked the divergent phenotypes observed in patients, which range from neuropathic disease with short lifespans to others with no evident CNS involvement and longer survival times. GWA analysis identified a small collection of candidate loci underlying the variable strain phenotypes, which successfully allowed to predict the severity of the disease in other strains upon GD induction and to identify a novel therapy for the neuropathic forms of GD. [email protected] J Tissue Sci Eng Volume 7, Issue 3(Suppl) ISSN: 2157-7552 JTSE, an open access journal Regenerative & Precision Medicine 2016 December 1-2, 2016 Page 52 J Tissue Sci Eng 2016, 7:3(Suppl) conferenceseries.com http://dx.doi.org/10.4172/2157-7552.C1.031 Global Congress on Tissue Engineering, Regenerative & Precision Medicine December 1-2, 2016 | San Antonio, USA Network based approach for analyzing complexities associated with diseases and its impact on personalized medicine Priyanka Narad Amity University, India standout amongst the most critical assignments of integrated Bioinformatics is to connect the gaps among different A information areas, from the fundamental investigations of genomics, proteomics, and metabolomics to a level based system where all connections are represented in a coherent picture. A holistic understanding of the basic molecular mechanisms underlying any biological process is important for the application of biological science to personalized medicine. Issues of unavailable information, dissimilar information sources, wasteful work process, and incapable corresponding
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