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Autism Spectrum Disorders 18th SSBP International Research Symposium Behavioural Phenotypes from bench to bedside: translation of basic science to clinical practice Programme Book 3rd – 5th September 2015 • London, UK Media Partners Submit your next manuscript to one of our many Neuroscience journals Open access 2 www.molecularautism.com www.behavioralandbrainfunctions.com Impact factor: 5.41 Impact factor: 1.97 biomedcentral.com A20486 | Image: psdesign1 / Fotolia A fresh start for psychiatry Psychiatry is at a turning point in its history. Cutting edge biomedical research, new concepts in service delivery, and increased awareness of the interaction between physical and mental health are transforming the specialty. Mental health practitioners need a source of information that is authoritative, innovative, and pragmatic. The Lancet Psychiatry is that source. To learn more about the scope and aims of the journal visit www.thelancet.com/psychiatry, or submit a manuscript at http://ees.elsevier.com/thelancetpsych. Psychiatry www.thelancet.com/psychiatry THE LANCET® is a registered trademark of Reed Elsevier Properties SA, used under licence. TLP_house_ad_SSBP_contra_167x117mm.indd 1 31/07/2015 17:55 18th International SSBP Research Symposium The Society for the Study 3 of Behavioural Phenotypes 3rd – 5th September 2015 The 18th SSBP International Research Symposium Behavioural Phenotypes from bench to bedside: translation of basic science to clinical practice London, UK 3rd – 5th September 2015, London, UK Contents Contents Media Partners ..........................................................................................................................................................................................2 Welcome to London .............................................................................................................................................................................9 London Conference Organisers ................................................................................................................................................10 4 Scientific Committee ..........................................................................................................................................................................11 The SSBP .......................................................................................................................................................................................................12 The SSBP Executive Committee ............................................................................................................................................................................12 Meetings of the SSBP ....................................................................................................................................................................................................13 Forthcoming Meetings of the SSBP.....................................................................................................................................................................13 Tom Oppé and the Tom Oppé Distinguished Lecture ............................................................................................ 14 Tom Oppé Lecturers ......................................................................................................................................................................................................14 2015 Tom Oppé Distinguished Lecturer: Professor Sir Michael Rutter ...........................................................................................14 Patricia Howlin and the Patricia Howlin Prize Lecture ............................................................................................15 Patricia Howlin Lecturers ............................................................................................................................................................................................15 2015 Patricia Howlin Lecturer: Supriya Malik ...................................................................................................................................................15 Sponsors ......................................................................................................................................................................................................16 Keynote Speaker Profiles ................................................................................................................................................................17 Professor Mark Good .....................................................................................................................................................................................................17 Professor David Skuse ...................................................................................................................................................................................................17 Professor Nessa Carey ...................................................................................................................................................................................................17 Dr Paramala Santosh .....................................................................................................................................................................................................18 Professor Annette Karmiloff-Smith .......................................................................................................................................................................18 Professor David Nutt......................................................................................................................................................................................................19 Professor Richard Festenstein .................................................................................................................................................................................20 Professor Jaqueline Crawley ....................................................................................................................................................................................20 Professor Sébastien Jacquemont ..........................................................................................................................................................................21 Professor Tony Charman .............................................................................................................................................................................................21 Conference Programme Programme ...................................................................................................................................22 Continuing Education and Keynote Day ..........................................................................................................................................................22 Research Symposium ...................................................................................................................................................................................................23 18th International SSBP Research Symposium Contents Abstracts for Continuing Education and Keynote Day .........................................................................................26 Keynote 1: Evaluating Cognitive and Affective Function in Mouse Models of Alzheimer’s Disease and Down Syndrome. ........................................................................................................................................................................................26 Keynote 2: Optimizing diagnostic criteria for Autism Spectrum Disorders ...............................................................................27 Keynote 3: Epigenetic Mechanisms in Developmental Disorders ..................................................................................................28 Keynote 4: Behavioural phenotypes that can be pharmacologically targeted in rare diseases – the Centre for Interventional Paediatric Psychopharmacology and Rare Diseases (CIPPRD) model ..............29 5 Keynote 5: What can babies with Down syndrome possibly tell us about Alzheimer’s dementia in adults? .....30 Keynote 6: Can We Use Neuro-Imaging to Develop New Treatments for Developmental Disorders? ....................31 Abstracts for Research Symposium – Oral Presentations ....................................................................................32 Keynote 7: Overcoming Triplet-Repeat Mediated Epigenetic Silencing in Humans ............................................................32 Talk 1: Fetal Growth and Gestational Factors as Predictors of Schizophrenia in 22q11.2 Deletion Syndrome .........33 Talk 2 : Does the Behavioural Phenotype of Lesch-Nyhan Disease/Lesch Nyhan Variant Disorder Correlate Best with Hprt or Gprt Enzyme Activity? ......................................................................................................................... 34 Talk 3: Sensory Processing in Children with Neurocognitive Syndromes ....................................................................................35 Talk 4: Molecular Biomarkers For Targeted Treatments In Fragile X Syndrome........................................................................36 Keynote 8: Intellectual Disability and Mental Health: Assessing Genomic
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