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University of Groningen Aphthae with Special Reference to the Chronic University of Groningen Aphthae with special reference to the chronic recurrent variety of Mikulicz Theron, Jacobus Arnoldus IMPORTANT NOTE: You are advised to consult the publisher's version (publisher's PDF) if you wish to cite from it. Please check the document version below. Document Version Publisher's PDF, also known as Version of record Publication date: 1959 Link to publication in University of Groningen/UMCG research database Citation for published version (APA): Theron, J. A. (1959). Aphthae with special reference to the chronic recurrent variety of Mikulicz: a clinical, etiological and histological study. [S.n.]. Copyright Other than for strictly personal use, it is not permitted to download or to forward/distribute the text or part of it without the consent of the author(s) and/or copyright holder(s), unless the work is under an open content license (like Creative Commons). The publication may also be distributed here under the terms of Article 25fa of the Dutch Copyright Act, indicated by the “Taverne” license. More information can be found on the University of Groningen website: https://www.rug.nl/library/open-access/self-archiving-pure/taverne- amendment. Take-down policy If you believe that this document breaches copyright please contact us providing details, and we will remove access to the work immediately and investigate your claim. Downloaded from the University of Groningen/UMCG research database (Pure): http://www.rug.nl/research/portal. For technical reasons the number of authors shown on this cover page is limited to 10 maximum. Download date: 07-10-2021 APHTHAE WITH SPECIAL REFERENCE TO THE CHRONIC RECURRENT VARIETY OF MIKULICZ J,A. THERON ERRATA p. 64 l. 43 ulcerine, read urine p. 88 1. 36 without symptoms, read without nervous symptoms. p. 104 1. 16 nature (Anderman 1950; read nature. From the literature (Ander­ man (1950; p. 110 Under "Introduction" line 2 to 5 should read as follows: In a study of the toxic properties of Actina ria, Richet and his colleagues found that during repeated injection of an extract of the tentacles of this sea anemone into dogs, definite •vmptoms appeared. In some instances the symptoms were so severe that death ensued. p. 145 1. 16 page and, read page 140 and p. 157 l. 16 (see page ). , read (see page 154). p. 16'1 1. 21 (see page ). , read (see page 121). RIJKSUNIVERSITEIT TE GRONINGEN APHTHAE WITH SPECIAL REFERENCE TO THE CHRONIC RECURRENT VARIETY OF MIKULICZ A CLINICAL, ETIOLOGICAL AND HISTOLOGICAL STUDY PROEPSCHRIPT TER VERKRIJGING VAN DE GRAAD VAN OOC:TOR IN DE GENEESKUNDE AAN DE RlJKSUNT".'ER­ SlTEIT TE GRONINGEN OP GEZAG VAN DE RECTOR MAGNIPICUS Dr. P. J. BOUMAN, HOOGLERAAR IN DE PACULTEIT DER RECHTSGELEERDHEID, IN HET OPEN­ SAAR TE VERDEDIGEN OP WOENSDAG 2 DECEMBER 1959 DES NAMIDDAGS TE 3 UUR PRECIES DOOR JACOBUS .ARNOLDUS THERON GEBOREN TE PRANKPORT, ORANJE-VRIJSTAAT, ZUID-APRIKA DRUK• V.R.B. KLEINE DER A 1 • GRONINGEN PROMOTOR: PROP. M. HUT STELLINGEN 1. Chronische recidiverende aphthae worden niet veroorzaakt door het herpes simplex virus. 2. Bij langdurig gebruik van gefluorideerd drinkwater, dient men met de mogelijkheid van strumavorming rekening te houden. 3. Het verdient ernstige overweging de gebruikelijke behan­ deling van favus capitis door middel van een eenmalige ROntgenepilatiedosis, als routinemethode te vervangen door het orale antimycoticum griseofulvine. 4. Er bestaat geen bewijs voor de opvatting dat onyalai wordt veroorzaakt door het innemen van middelen verschaft door medicijnmannen ( "toordokters 11). 5. Bij gereguleerde diabetici bestaat er geen contra-indicatie tegen het gebruik van locale anaesthetica waaraan adrena­ line is toegevoegd. 6. Bij de bereiding van antigenen waarbij gebruik gemaakt wordt van Tyndallisatie, is het belangrijk om de tempe­ ratuur die daarbij wordt gebruikt te vermelden. 7. Het ROntgenol0gische beeld van nephroblastoma van de mandibula lijkt zeer veel op dat van neuroblastoma van de mandibula. A.Nesbiu.Brit.dent.J. 106:251, 1959. 8. Allergie komt bij de Bantoes minder frequent voor dan bij blank en. 9. Bij de opleiding van huisartsen wordt te weinig aandacht geschonken aan de ziekten van de mondholte. 10. Massale bloeding van de tractus gastro-intestinalis is een zeldzame complicatie van appendectomie. Ter nagedagtenis aan my Vader Aan my Moeder Aan my Skoonouers Aan Killa As a result of a lack of time, due to circumstances beyond the control of the author and the printer, the necessary cor­ rections of the proofs of the case histories had to be omitted. VOORWOORD Graag wil ek almal wat meegehelp het om hierdie proefskrif die lig te laat sien van harte bedank. Om almal by name te noem is onmoontlik. Tog is ek ver­ plig om 'n paar uitsonderings te maak. Hooggeleerde Hut, hooggeagte promotor, aanum y opregte dank vir die geleentheid om vir tweejaar as assistent op die af­ deling Mondheelkunde, Groningen, te kon werk. Die v'ryheid wat u my gelaat het om hierdie ondersoek te kon uitvoer word besonder waardeer. Hooggeleerde Ruiter, die geleentheid wat ek gehad het om uit u groat kennis en ervaring as dermatoloog van naam te kon put, was vir my 'n besondere eer en voorreg. Vir u on­ misbare hulp kan ek u nie genoeg bedank nie. SeergeleeJ·de Dekking, die hulp wat ek van u ontvang het op die Virus-laboratorium te Amsterdam sal vir my steeds 'n aangename herinnering bly. Namens my vrou en my, harte like dankoak aanMev. Dekking vir die gasvryheid wat ons by u aan huis geniet het. Hooggeleerde Keuning, vir die fasiliteite tot my beskik­ king gestel op u laboratorium asook vir die talle kere wat u my van advies bedien het my opregte dank. Hooggeleerde Hadders, ontvangmy dank vir die baie kere wat u my van raad bedien het. Hooggeleerde Huizinga, aan u en die personeel van die hospitaal-apteek is ek veel verskuldig vir die hulp by die be­ reiding van die antigene. Hooggeleerde Hagedoorn, u wil ek bedank vir die aph­ thosis-pasient tot my beskikking gestel, asook vir u gasvry­ heid my aange bied op die Oogheelkunde -kliniek te Amsterdam. Hooggeleerde ten Berge, u word bedank vir die bedde tot my beskikking gestel op die Vroue-afdeling. Hooggeleerde Dekking, oak aan u wil ek s� dankie vir die feit dat ek pasiente op die Oogheelkunde-afdeling, Groningen, kon opneem. Seergeleerde Groen, sander die hulp wat ek van u en die personeel van die Sentraal-laboratorium ontvang het, sou die baie laboratoriumondersoeke nie uitgevoer kon word nie. Seergeleerde Beute, vir die bakteriologie-onderzoek is ek aan u baie dank verskuldig. Seergeleerde Van de Poel, vir u hulp by die patologies­ anatomiese ondersoek my opregte dank. Seergeleerde Weeke, my erkentlikheid teenoor u vir die hulp by die endokrinologie-ondersoek. Aan al my mede-assistente wil ek baie dankie s� vir die hulp en vriendskap wat ek van hulle ontvang het. Die hulp wat ek van die heer Nienhuis en die personeel van die Universiteitsbiblioteek ontvang het, stel ek hoog op prijs. Aan Mejj. Mllnninghoff en Grootes my hartelike dank vir die oortik van die manuskrip. Louis Eksteen word bedank vir die taalkundige versor­ ging van die proefskrif . Aan my landgenote in Groningen dankie vir die morele steun . In die ve rband 'n spesiale woord van dank aan Emil en Cecile Loubser vir al die blyke van vriendskap. Graag wil ek die Regering van Nederland bedank vir die beurs aan my toegeken. Tenslotte, aan jou, Killa baie dankie vir jou onmisbare hulp en vir al die opoffe ring wat jy jou getroos het . Jou on ­ baatsugtige liefde was vir my altyd 'n inspirasie. CONTENTS Introduction Chapt er I HISTORICAL NOTES ON APHTHAE ... ... 11 Chapt er II CLASSIFICATION OF CLINICAL ENTITIES CHARAC TERIZED BY THE FORMATION OF APHTHAE OR WHICH AT SOME TIME OR OTHER HAVE BEEN DESIGNATED AS SUCH ... ... ....... .....................17 Chapter III APHTHOUS DISEASES OF KNOWN ETIO- LOGY .....................••.......... 25 A. Due to herpes simplex virus . ....•.... 25 1. Acute aphthous stomatitis .......... 25 2. Aphthoid of Pospischill. 2 9 3. Dermatitis fibrinosa faciei . ........ 29 4. Herpes labialis ................... 30 5. Herpes corneae ......•............ 31 6. Herpes progenitalis ................31 7. Eczema herpeticum ...........•....31 8. Herpes encephalitis ...•.......•....32 9. Herpes sepsis ...........•..••..... 32 10. Other manifestations of herpes in- fection ........................... 33 The histological picture of acute apththous stomatitis ......•..•...•....•.•...••. 33 B. Herpangina ............. ............. 35 C. Aphthae epizooticae (Foot and mouth dis- ease) ........•.......................36 D. Vesicular stomatitis ..................37 E. False foot and mouth disease ....•..... 37 F. Traumatic lesions of the oral muc osa.. 38 Appendix: Bednar' s aphthae ........... 3 9 Chapter IV APHTHOUS DISEASE OF DOUBTFUL ETIO- LOGY ••...•....••..••••• .•..•..........40 A. Aphthosis . • . • . • . • 40 Introduction .........•................40 Ulcus vulvae acutum ..••.•..•.•••..•..40 Beh�et' s syndrome ......•.•..........43 Aphthosis ......................•.... 43 Dermatostomatitis. • . 44 Ectodermosis erosiva pluriorificialis .. 44 St evens-Johnson disease .............. 45 Chronic recurrent aphthosis •..........45 B. The clinical picture of aphthosis ....... 48 I. Mucosal lesions ................•.. 49 II. Skin lesions ....................... 53 III. Eye manifestations ..............•..55 IV. Mu scle and joint manifestations ..... 56 V. Lung manifestations ............... 56 VI. Involvement of the nervous system .. 57 VII. Urethritis ........................ 58 Vlll. Gener al malaise ..........
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