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Supplementary material BMJ Open PHARMACEUTICAL BENEFITS SCHEME CODES AMT MPP = Australian Medical Terminology Medicinal Product Pack, ATC = Anatomical Therapeutic Chemical, PBS = Pharmaceutical Benefits Scheme codes Summary of drug categories and ATC codes used to identify PBS codes Function Examples ATC codes Antiplatelet Aspirin, clopidogrel, prasugrel, B01AC04, B01AC06, B01AC22, ticagrelor B01AC24, B01AC30 Lipid modification Statins, fibrates C09~, C10AA~, C10AB~, C10AC~, C10AD~, C10AX~, C10AX09, C10AX13, C10BA~, C10BX~ Symptom relief ß-blockers, nitrates, calcium channel C01DA~, C01DX16, C01EB17, C07AA~ blockers C07AB~, C07AG~, C08CA~, C08CX~, C08DA~, C08DB~, C08EA~, C08EX~, C08GA~ Full list of PBS codes used in this research PBS ATC code Drug category Drug name AMT MPP name code 8358X B01AC04 Antiplatelet clopidogrel clopidogrel 75 mg tablet, 28 5436D B01AC04 Antiplatelet clopidogrel clopidogrel 75 mg tablet, 28 9317J B01AC04 Antiplatelet clopidogrel clopidogrel 75 mg tablet, 28 4179Y B01AC04 Antiplatelet clopidogrel clopidogrel 75 mg tablet, 28 9354H B01AC04 Antiplatelet clopidogrel clopidogrel 75 mg tablet, 28 2275R B01AC04 Antiplatelet clopidogrel clopidogrel 75 mg tablet, 28 8202Q B01AC06 Antiplatelet aspirin aspirin 100 mg tablet, 112 4078P B01AC06 Antiplatelet aspirin aspirin 100 mg capsule: enteric, 84 4076M B01AC06 Antiplatelet aspirin aspirin 100 mg tablet, 90 4077N B01AC06 Antiplatelet aspirin aspirin 100 mg tablet: enteric, 84 1010E B01AC06 Antiplatelet aspirin aspirin 300 mg tablet: effervescent, 96 9495R B01AC22 Antiplatelet prasugrel prasugrel 5 mg tablet, 28 9496T B01AC22 Antiplatelet prasugrel prasugrel 10 mg tablet, 28 1418P B01AC24 Antiplatelet Ticagrelor Ticagrelor Tablet 90 mg, 56 8382E B01AC30 Antiplatelet dipyridamole + aspirin dipyridamole 200 mg + aspirin 25 mg capsule: modified release, 60 capsules 9296G B01AC30 Antiplatelet clopidogrel + aspirin clopidogrel 75 mg + aspirin 100 mg tablet, 30 1516T C01DA02 Nitrate glyceryl trinitrate glyceryl trinitrate 10 mg/24 hours patch, 30 1515R C01DA02 Nitrate glyceryl trinitrate glyceryl trinitrate 5 mg/24 hours patch, 30 8027L C01DA02 Nitrate glyceryl trinitrate glyceryl trinitrate 5 mg/24 hours patch, 30 8011P C01DA02 Nitrate glyceryl trinitrate glyceryl trinitrate 10 mg/24 hours patch, 30 2588F C01DA08 Nitrate isosorbide dinitrate isosorbide dinitrate 5 mg tablet: sublingual, 100 McCreanor V, et al. BMJ Open 2019; 9:e029360. doi: 10.1136/bmjopen-2019-029360 Supplementary material BMJ Open PBS ATC code Drug category Drug name AMT MPP name code 5108W C01DA02 Nitrate glyceryl trinitrate glyceryl trinitrate 600 microgram tablet: sublingual, 100 tablets 1558B C01DA14 Nitrate isosorbide isosorbide mononitrate 60 mg tablet: modified mononitrate release, 30 tablets 8028M C01DA02 Nitrate glyceryl trinitrate glyceryl trinitrate 10 mg/24 hours patch, 30 3475X C01DA02 Nitrate glyceryl trinitrate glyceryl trinitrate 400 microgram/actuation spray, 200 actuations 1459T C01DA02 Nitrate glyceryl trinitrate glyceryl trinitrate 600 microgram tablet: sublingual, 100 tablets 8026K C01DA02 Nitrate glyceryl trinitrate glyceryl trinitrate 15 mg/24 hours patch, 30 8171C C01DA02 Nitrate glyceryl trinitrate glyceryl trinitrate 400 microgram/actuation spray, 200 actuations 8273K C01DA14 Nitrate isosorbide isosorbide mononitrate 120 mg tablet: modified mononitrate release, 30 tablets 8119H C01DA02 Nitrate glyceryl trinitrate glyceryl trinitrate 15 mg/24 hours patch, 30 8010N C01DA02 Nitrate glyceryl trinitrate glyceryl trinitrate 5 mg/24 hours patch, 30 8229D C01DX16 Vasodilator nicorandil nicorandil 20 mg tablet, 60 8228C C01DX16 Vasodilator nicorandil nicorandil 10 mg tablet, 60 2960T C01EB17 Symptom relief - ivabradine ivabradine 7.5 mg tablet, 56 other 10012Y C01EB17 Symptom relief - ivabradine ivabradine 5 mg tablet, 56 other 2942W C07AA02 Beta blocker oxprenolol oxprenolol hydrochloride 20 mg tablet, 100 2566C C07AA05 Beta blocker propranolol propranolol hydrochloride 40 mg tablet, 100 2899N C07AA05 Beta blocker propranolol propranolol hydrochloride 160 mg tablet, 50 3062E C07AA03 Beta blocker pindolol pindolol 5 mg tablet, 100 2565B C07AA05 Beta blocker propranolol propranolol hydrochloride 10 mg tablet, 100 2961W C07AA02 Beta blocker oxprenolol oxprenolol hydrochloride 40 mg tablet, 100 3065H C07AA03 Beta blocker pindolol pindolol 15 mg tablet, 50 2243C C07AB03 Beta blocker atenolol atenolol 50 mg/10 mL oral liquid, 300 mL 8733P C07AB02 Beta blocker metoprolol succinate metoprolol succinate Tablet 47.5 mg (controlled release), 30 1325R C07AB02 Beta blocker metoprolol tartrate metoprolol tartrate Tablet 100 mg, 60 8735R C07AB02 Beta blocker metoprolol succinate metoprolol succinate Tablet 190 mg (controlled release), 30 8732N C07AB02 Beta blocker metoprolol succinate metoprolol succinate Tablet 23.75 mg (controlled release), 15 8604W C07AB07 Beta blocker bisoprolol bisoprolol fumarate 2.5 mg tablet, 28 9311C C07AB12 Beta blocker nebivolol nebivolol 5 mg tablet, 28 8605X C07AB07 Beta blocker bisoprolol bisoprolol fumarate 5 mg tablet, 28 9316H C07AB12 Beta blocker nebivolol nebivolol 1.25 mg tablet, 28 8734Q C07AB02 Beta blocker metoprolol succinate metoprolol succinate Tablet 95 mg (controlled release), 30 1081X C07AB03 Beta blocker atenolol atenolol 50 mg tablet, 30 9312D C07AB12 Beta blocker nebivolol nebivolol 10 mg tablet, 28 8606Y C07AB07 Beta blocker bisoprolol bisoprolol fumarate 10 mg tablet, 28 1324Q C07AB02 Beta blocker metoprolol tartrate metoprolol tartrate Tablet 50 mg, 100 1567L C07AG01 Beta blocker labetalol labetalol hydrochloride 200 mg tablet, 100 McCreanor V, et al. BMJ Open 2019; 9:e029360. doi: 10.1136/bmjopen-2019-029360 Supplementary material BMJ Open PBS ATC code Drug category Drug name AMT MPP name code 8256M C07AG02 Beta blocker carvedilol carvedilol 6.25 mg tablet, 60 8258P C07AG02 Beta blocker carvedilol carvedilol 25 mg tablet, 60 8257N C07AG02 Beta blocker carvedilol carvedilol 12.5 mg tablet, 60 1566K C07AG01 Beta blocker labetalol labetalol hydrochloride 100 mg tablet, 100 8255L C07AG02 Beta blocker carvedilol carvedilol 3.125 mg tablet, 30 8679T C08CA13 Calcium channel lercanidipine lercanidipine hydrochloride 20 mg tablet, 28 blocker 8534E C08CA13 Calcium channel lercanidipine lercanidipine hydrochloride 10 mg tablet, 28 blocker 1695F C08CA05 Calcium channel nifedipine nifedipine 20 mg tablet, 60 blocker 2367N C08CA02 Calcium channel felodipine felodipine 10 mg tablet: modified release, 30 blocker tablets 1907J C08CA05 Calcium channel nifedipine nifedipine 60 mg tablet: modified release, 30 blocker tablets 2752W C08CA01 Calcium channel amlodipine amlodipine 10 mg tablet, 30 blocker 2751T C08CA01 Calcium channel amlodipine amlodipine 5 mg tablet, 30 blocker 1906H C08CA05 Calcium channel nifedipine nifedipine 30 mg tablet: modified release, 30 blocker tablets 2361G C08CA02 Calcium channel felodipine felodipine 2.5 mg tablet: modified release, 30 blocker tablets 8610E C08CA05 Calcium channel nifedipine nifedipine 20 mg tablet: modified release, 30 blocker tablets 1694E C08CA05 Calcium channel nifedipine nifedipine 10 mg tablet, 60 blocker 2366M C08CA02 Calcium channel felodipine felodipine 5 mg tablet: modified release, 30 tablets blocker 1250T C08DA01 Calcium channel verapamil verapamil hydrochloride 80 mg tablet, 100 blocker 2207E C08DA01 Calcium channel verapamil verapamil hydrochloride 240 mg capsule: modified blocker release, 30 capsules 2206D C08DA01 Calcium channel verapamil verapamil hydrochloride 160 mg capsule: modified blocker release, 30 capsules 1248Q C08DA01 Calcium channel verapamil verapamil hydrochloride 40 mg tablet, 100 blocker 2208F C08DA01 Calcium channel verapamil verapamil hydrochloride 180 mg tablet: modified blocker release, 30 tablets 1241H C08DA01 Calcium channel verapamil verapamil hydrochloride 240 mg tablet: modified blocker release, 30 tablets 1312C C08DB01 Calcium channel diltiazem diltiazem hydrochloride 180 mg capsule: modified blocker release, 30 capsules 1335G C08DB01 Calcium channel diltiazem diltiazem hydrochloride 60 mg tablet, 90 blocker 1313D C08DB01 Calcium channel diltiazem diltiazem hydrochloride 240 mg capsule: modified blocker release, 30 capsules 8480H C08DB01 Calcium channel diltiazem diltiazem hydrochloride 360 mg capsule: modified blocker release, 30 capsules 2147B C09CA08 Renin- olmesartan medoxomil olmesartan medoxomil 20 mg tablet, 30 angiotensin system agent McCreanor V, et al. BMJ Open 2019; 9:e029360. doi: 10.1136/bmjopen-2019-029360 Supplementary material BMJ Open PBS ATC code Drug category Drug name AMT MPP name code 1182F C09AA09 Renin- fosinopril fosinopril sodium 10 mg tablet, 30 angiotensin system agent 1183G C09AA09 Renin- fosinopril fosinopril sodium 20 mg tablet, 30 angiotensin system agent 2836G C09DX03 Renin- olmesartan + olmesartan medoxomil 40 mg + amlodipine 10 mg angiotensin amlodipine + + hydrochlorothiazide 12.5 mg tablet, 30 system agent hydrochlorothiazide 2136K C09DA04 Renin- irbesartan + irbesartan 300 mg + hydrochlorothiazide 25 mg angiotensin hydrochlorothiazide tablet, 30 system agent 8590D C09BA06 Renin- quinapril + quinapril 20 mg + hydrochlorothiazide 12.5 mg angiotensin hydrochlorothiazide tablet, 30 system agent 10005N C09DX03 Renin- olmesartan + olmesartan medoxomil 20 mg + amlodipine 5 mg + angiotensin amlodipine + hydrochlorothiazide 12.5 mg tablet, 30 system agent hydrochlorothiazide 9120B C09AA05 Renin- ramipril ramipril 1.25 mg capsule, 30 angiotensin system agent 3050M C09AA04 Renin- perindopril perindopril erbumine 2 mg tablet, 30 angiotensin system
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  • Angiotensin-Converting Enzyme Inhibition but Not Angiotensin II Receptor Blockade Regulates Matrix Metalloproteinase Activity in Patients with Glomerulonephritis

    Angiotensin-Converting Enzyme Inhibition but Not Angiotensin II Receptor Blockade Regulates Matrix Metalloproteinase Activity in Patients with Glomerulonephritis

    J Am Soc Nephrol 14: 2861–2872, 2003 Angiotensin-Converting Enzyme Inhibition but not Angiotensin II Receptor Blockade Regulates Matrix Metalloproteinase Activity in Patients with Glomerulonephritis NADE` GE LODS,* PAOLO FERRARI,* FELIX J. FREY,* ANDREAS KAPPELER,† CELINE BERTHIER,* BRUNO VOGT,* and HANS-PETER MARTI* *Division of Nephrology and Hypertension, Inselspital Bern, Bern, Switzerland; and †Institute of Pathology, University of Bern, Bern, Switzerland Abstract. Equivalent long-term effects on the kidney are attrib- periods of 4 wk each without therapy. Untreated patients with uted to angiotensin-converting enzyme inhibitors (ACEI) and glomerulonephritis displayed distinctively higher serum levels angiotensin II type 1 receptor blockers (ARB). Nevertheless, it of MMP-2 but much lower MMP-1/-8/-9 concentrations com- is unknown to which degree effects of these compounds on pared with healthy control subjects. Immunohistology of individual inflammatory mediators, including matrix metallo- MMP-2 and MMP-9 in kidney biopsy specimen was accord- proteinases (MMP), are comparable. On the basis of structural ingly. However, these patients excreted higher amounts of and functional differences, it was hypothesized that ACEI and MMP-2 and MMP-9 in urine than healthy control subjects, ARB differentially regulate MMP activity. In a randomized, possibly reflecting ongoing glomerular inflammation. In pa- prospective crossover trial, the effect of an ACEI (fosinopril; tients with glomerulonephritis, ACEI significantly reduced 20 mg/d) and of an ARB (irbesartan; 150 mg/d) on MMP overall MMP serum activity to 25%, whereas ARB did not activity was evaluated. Ten hypertensive patients with glomer- show any effect. Activities of MMP-1/-2/-8/-9 were also sig- ulonephritis and normal or mildly reduced creatinine clearance nificantly inhibited by fosinopril but not by irbesartan.
  • Effects of Olmesartan Vs Irbesartan on Metabolic Parameters and Visfatin in Hypertensive Obese Women

    Effects of Olmesartan Vs Irbesartan on Metabolic Parameters and Visfatin in Hypertensive Obese Women

    European Review for Medical and Pharmacological Sciences 2010; 14: 759-763 Effects of olmesartan vs irbesartan on metabolic parameters and visfatin in hypertensive obese women D.A. DE LUIS, R. CONDE, M. GONZALEZ SAGRADO, R. ALLER, O. IZAOLA, J.L. PEREZ CASTRILLON, E. ROMERO, M.J. CASTRO Institute of Endocrinology and Nutrition, Medicine School and Unit of Investigation. Hospital Rio Hortega. RD-056/0013 RETICEF. University of Valladolid. Valladolid (Spain) Abstract. – Background: Angiotensin II reg- dence of this rising tide of obesity and associated ulates the production of adipokines. The objective pathologies has led, in the last years, to a dramat- was to study the effect of treatment with irbesartan versus olmesartan in obese hypertensive women. ic increase of researches on the role of adipose Subjects: A sample of 34 obese hypertensive tissue as an active participant in controlling the women was analyzed in a prospective way with a body’s physiology2. randomized trial. Patients were randomized to irbe- Visfatin was recently identified as a protein sartan (300 mg/day) or olmesartan (40 mg/day) for preferentially expressed in visceral adipose tis- 3 months. Weight, body mass index, blood pres- sue, compared with subcutaneous adipose tis- sure, basal glucose, insulin, total cholesterol, LDL- sue3. It can be found in skeletal muscle, liver, cholesterol, HDL-cholesterol, triglycerides, HOMA and visfatin were determined at basal time and af- bone marrow and lymphocytes, where it was ter 3 months of treatment. initially identified as pre-B-cell colony-enhanc- Results: Thirty four patients gave informed con- ing factor (PBEF). Fukuhara et al4 clearly sug- sent and were enrolled in the study.