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Molecular Pharming to Support Human Life on the Moon, Mars, and Beyond

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Molecular Pharming to Support Human Life on the Moon, Mars, and Beyond UC Berkeley UC Berkeley Previously Published Works Title Molecular pharming to support human life on the moon, mars, and beyond. Permalink https://escholarship.org/uc/item/0vc0786j Journal Critical reviews in biotechnology, 41(6) ISSN 0738-8551 Authors McNulty, Matthew J Xiong, Yongao Mary Yates, Kevin et al. Publication Date 2021-09-01 DOI 10.1080/07388551.2021.1888070 Peer reviewed eScholarship.org Powered by the California Digital Library University of California Critical Reviews in Biotechnology ISSN: (Print) (Online) Journal homepage: https://www.tandfonline.com/loi/ibty20 Molecular pharming to support human life on the moon, mars, and beyond Matthew J. McNulty, Yongao (Mary) Xiong, Kevin Yates, Kalimuthu Karuppanan, Jacob M. Hilzinger, Aaron J. Berliner, Jesse Delzio, Adam P. Arkin, Nancy E. Lane, Somen Nandi & Karen A. McDonald To cite this article: Matthew J. McNulty, Yongao (Mary) Xiong, Kevin Yates, Kalimuthu Karuppanan, Jacob M. Hilzinger, Aaron J. Berliner, Jesse Delzio, Adam P. Arkin, Nancy E. Lane, Somen Nandi & Karen A. McDonald (2021): Molecular pharming to support human life on the moon, mars, and beyond, Critical Reviews in Biotechnology, DOI: 10.1080/07388551.2021.1888070 To link to this article: https://doi.org/10.1080/07388551.2021.1888070 © 2021 The Author(s). Published by Informa View supplementary material UK Limited, trading as Taylor & Francis Group Published online: 09 Mar 2021. Submit your article to this journal Article views: 455 View related articles View Crossmark data Full Terms & Conditions of access and use can be found at https://www.tandfonline.com/action/journalInformation?journalCode=ibty20 CRITICAL REVIEWS IN BIOTECHNOLOGY https://doi.org/10.1080/07388551.2021.1888070 REVIEW ARTICLE Molecular pharming to support human life on the moon, mars, and beyond a,b a,bà a,bà a,c Matthew J. McNulty , Yongao (Mary) Xiong , Kevin Yates , Kalimuthu Karuppanan , Jacob M. Hilzingera,d , Aaron J. Berlinera,d , Jesse Delzioa,b, Adam P. Arkina,d , Nancy E. Lanee , Somen Nandia,b,f and Karen A. McDonalda,b,f aCenter for the Utilization of Biological Engineering in Space (CUBES), Berkeley, CA, USA; bDepartment of Chemical Engineering, University of California, Davis, CA, USA; cRadcliffe Department of Medicine, Oxford University, Oxford, UK; dDepartment of Bioengineering, University of California, Berkeley, CA, USA; eCenter for Musculoskeletal Health, School of Medicine, University of California, Davis, CA, USA; fGlobal HealthShareVR Initiative, University of California, Davis, CA, USA ABSTRACT ARTICLE HISTORY Space missions have always assumed that the risk of spacecraft malfunction far outweighs the Received 29 September 2020 risk of human system failure. This assumption breaks down for longer duration exploration mis- Revised 27 November 2020 sions and exposes vulnerabilities in space medical systems. Space agencies can no longer reduce Accepted 19 December 2020 the majority of the human health and performance risks through crew members selection pro- KEYWORDS cess and emergency re-supply or evacuation. No mature medical solutions exist to address this Plant molecular pharming; risk. With recent advances in biotechnology, there is promise for lessening this risk by augment- synthetic biology; ing a space pharmacy with a biologically-based space foundry for the on-demand manufacturing biomanufacturing; space of high-value medical products. Here we review the challenges and opportunities of molecular medicine; medical foundry; pharming, the production of pharmaceuticals in plants, as the basis of a space medical foundry medical countermeasure; to close the risk gap in current space medical systems. Plants have long been considered to be oxygenic photoautotroph; an important life support object in space and can now also be viewed as programmable facto- space exploration ries in space. Advances in molecular pharming-based space foundries will have widespread appli- cations in promoting simple and accessible pharmaceutical manufacturing on Earth. Re-thinking human health for deep systems will become increasingly burdensome. Current space missions exploration medical capabilities are particularly vulner- Humanity has collectively returned its gaze to the stars able to a lower rate of resupply and longer missions. as space agencies and companies around the world The list of necessary supplies to address persistent work to develop new strategies to extend human pres- exposures of space travel adds up quickly, including: ence farther into the universe. To arrive there, we need countermeasures for increased radiation [3,4], bone loss to transition from Earth-reliant to Earth-independent [5,6], kidney stones [7,8], vision impairment [9], and mission architecture. Agencies like the National adverse behavioral conditions [10] to name a few. The Aeronautics and Space Administration (NASA) and list of supplies begins to look unmanageable when you European Space Agency (ESA) have developed excep- add in intermittent, or even unanticipated, exposures tional life support systems for Earth-reliant human mis- such as microbial infection [11–13], and spaceflight- sions into space [1]. Carefully planned medicine, food, induced genome instability and metabolic changes and environmental control re-supply shuttles working [14]. As mission duration increases, the risk of a low in concert with on-board environmental control and life support systems maintain a habitable environment for probability medical condition is amplified. When an astronauts in the International Space Station (ISS) [2]. astronaut is on Mars and the closest hospital or medical However, as space missions become longer and they re-supply is at least 200 days of interplanetary travel probe deeper into the solar system – to the Moon, to away [15], it is critical that astronauts are medically Mars, and beyond – frequent re-supplies for life support self-sufficient. CONTACT Karen A. McDonald [email protected] Department of Chemical Engineering, University of California, Davis, CA, USA *These authors contributed equally for this manuscript Supplementary data for this article can be accessed here. ß 2021 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way. 2 M. J. MCNULTY ET AL. Furthermore, the recent literature highlights sys- An alternative method for pharmaceutical produc- temic vulnerabilities in space-flown pharmaceutical life tion is chemical synthesis. In producing small mol- support in the biased and underreported historical data ecule pharmaceuticals, chemical synthesis is often of in-flight pharmaceutical use and efficacy, limited advantageous on Earth. However, as stereochemical fidelity of current ground-analog models, and the in- complexity and size of the target pharmaceutical flight instability of drug formulations [16]. Of the small increases, chemical synthesis often becomes dramatic- molecule solid formulations tested thus far, three-quar- ally less feasible and attractive. For perspective, there ters will have degraded by the end of the proposed first are examples of chemical synthesis used commercially Mars mission duration [15]. There has been no space- to produce pharmaceuticals as large as peptides flight testing of biologics, a critical category of pharma- (5–50 amino acids) [22,23], but antibodies, an ceuticals known to be less stable than small molecule example class of life-saving pharmaceuticals produced drugs [17,18]. These issues highlight the need to only in biological systems (termed “biologics”), are develop platform technologies for the on-demand pro- two orders of magnitude larger (1,400 amino acids) duction of medicines. than that. Chemical synthesis of pharmaceuticals can also be contrasted with biological production as hav- ing highly reaction-specific inputs and complex syn- Defining a medical foundry for space thesis steps, often requiring the use of organic exploration solvents and generating substantial waste by-prod- The medical systems of future space exploration will ucts, all of which are undesirable attributes for space need to be reconfigured to guarantee astronaut health. applications. Chemical synthesis may be necessary for The contemporary standard is the NASA-provided ISS a robust medical foundry for space, indeed it will crew health care system (CHeCS) consisting of three likely be required to synthesize nucleic acids to sub-systems: (1) the countermeasures system (CMS) mobilize biological production in space [24], but it composed of exercise hardware and monitoring devi- will not be sufficient to produce all countermeasures. ces, (2) the environmental health system (EHS) com- Space biotechnology has primarily focused on posed of hardware for environmental monitoring, and microbes [15,20], fungi [25], and plants [20,26]. (3) the health maintenance system (HMS) composed of From this perspective, we review the potential utility a medical kit for supporting routine minor medical of plants as a molecular medical foundry for the pro- needs for up to 180 days [19]. Earth-reliant medical sys- duction of pharmaceuticals in deep space and tems like CHeCS will need to be augmented with med- contrast this with the capabilities
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