Chapter 3 – Skeletal and Muscular System Subject - Science Class V
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Mesenchymal Stem Cells in Combination with Hyaluronic Acid
www.nature.com/scientificreports OPEN Mesenchymal Stem Cells in Combination with Hyaluronic Acid for Articular Cartilage Defects Received: 1 August 2017 Lang Li1, Xin Duan1, Zhaoxin Fan2, Long Chen1,3, Fei Xing1, Zhao Xu4, Qiang Chen2,5 & Accepted: 19 April 2018 Zhou Xiang1 Published: xx xx xxxx Mesenchymal stem cells (MSCs) and hyaluronic acid (HA) have been found in previous studies to have great potential for medical use. This study aimed to investigate the therapeutic efects of bone marrow mesenchymal stem cells (BMSCs) combined with HA on articular cartilage repair in canines. Twenty-four healthy canines (48 knee-joints), male or female with weight ranging from 5 to 6 kg, were operated on to induce cartilage defect model and divided into 3 groups randomly which received diferent treatments: BMSCs plus HA (BMSCs-HA), HA alone, and saline. Twenty-eight weeks after treatment, all canines were sacrifced and analyzed by gross appearance, magnetic resonance imaging (MRI), hematoxylin-eosin (HE) staining, Masson staining, toluidine blue staining, type II collagen immunohistochemistry, gross grading scale and histological scores. MSCs plus HA regenerated more cartilage-like tissue than did HA alone or saline. According to the macroscopic evaluation and histological assessment score, treatment with MSCs plus HA also lead to signifcant improvement in cartilage defects compared to those in the other 2 treatment groups (P < 0.05). These fndings suggested that allogeneic BMSCs plus HA rather than HA alone was efective in promoting the formation of cartilage-like tissue for repairing cartilage defect in canines. Articular cartilage is composed of chondrocyte and extracellular matrix and has an important role in joint move- ment including lubrication, shock absorption and conduction. -
(AMIC) Compared to Microfractures for Chondral Defects of the Talar Shoulder: a Five-Year Follow-Up Prospective Cohort Study
life Communication Autologous Matrix Induced Chondrogenesis (AMIC) Compared to Microfractures for Chondral Defects of the Talar Shoulder: A Five-Year Follow-Up Prospective Cohort Study Filippo Migliorini 1 , Jörg Eschweiler 1, Nicola Maffulli 2,3,4,5,* , Hanno Schenker 1, Arne Driessen 1 , Björn Rath 1,6 and Markus Tingart 1 1 Department of Orthopedics and Trauma Surgery, University Clinic Aachen, RWTH Aachen University Clinic, 52064 Aachen, Germany; [email protected] (F.M.); [email protected] (J.E.); [email protected] (H.S.); [email protected] (A.D.); [email protected] (B.R.); [email protected] (M.T.) 2 School of Pharmacy and Bioengineering, Keele University School of Medicine, Staffordshire ST4 7QB, UK 3 Barts and the London School of Medicine and Dentistry, London E1 2AD, UK 4 Centre for Sports and Exercise Medicine, Queen Mary University of London, Mile End Hospital, London E1 4DG, UK 5 Department of Orthopedics, Klinikum Wels-Grieskirchen, A-4600 Wels, Austria 6 Department of Medicine, Surgery and Dentistry, University of Salerno, 84081 Baronissi, Italy * Correspondence: [email protected] Abstract: Introduction: Many procedures are available to manage cartilage defects of the talus, Citation: Migliorini, F.; Eschweiler, J.; including microfracturing (MFx) and Autologous Matrix Induced Chondrogenesis (AMIC). Whether Maffulli, N.; Schenker, H.; Driessen, AMIC or MFx are equivalent for borderline sized defects of the talar shoulder is unclear. Thus, the A.; Rath, B.; Tingart, M. Autologous present study compared the efficacy of primary isolated AMIC versus MFx for borderline sized Matrix Induced Chondrogenesis focal unipolar chondral defects of the talar shoulder at midterm follow-up. -
Lung Transplantation with the OCS (Organ Care System)
Lung Transplantation with the OCSTM (Organ Care System) Lung System Bringing Breathing Lung Preservation to Transplant Patients A Guide for You and Your Family DRAFT ABOUT THIS BOOKLET This booklet was created for patients like you who have been diagnosed with end-stage lung failure and are candidates for a lung transplant. It contains information that will help you and your family learn about options available to you for a transplant. This booklet includes information on your lungs, how they function, and respiratory failure. In addition, you will learn about a new way to preserve lungs before transplantation, called breathing lung preservation. Your doctor is the best person to explain your treatment options and their risks and to help you decide which option is right for you. The booklet explains: • Breathing lung preservation with the OCS™ Lung System • How the OCS™ Lung System works • Who is eligible for the OCS™ Lung System • Lung transplant complications • How the lungs function • What is respiratory failure and the treatment options • What to expect during your treatment • Summary of clinical data for the OCS™ Lung System • Contact Information Please read this booklet carefully and share it with your family and caregivers. For your convenience, a glossary is provided in the front of this booklet. Terms in the text in bold italics are explained in the glossary. If you have questions about the OCS™ Lung System that are not answered in this booklet, please ask your physician. This booklet is intended for general information only. It is not intended to tell you everything you need to know about a lung transplant. -
Series 1100TDM Tandem MEGALUG Mechanical Joint Restraint
Series 1100TDM Tandem MEGALUG® Mechanical Joint Restraint High Pressure Restraint for Ductile Iron Pipe Features and Applications: • For use on Ductile Iron Pipe 4 inch through 54 inch • High Pressure Restraint • Torque Limiting Twist-Off Nuts • Mechanical Joint follower gland incorporated into the restraint • MEGA-BOND® Coating System For more information on MEGA- BOND, visit our web site at www. ebaa.com • Minimum 2 to 1 Safety Factor Series 1112TDM restraining a mechanical joint fitting. • Constructed of A536 Ductile Iron Post Pressure Rating • EBAA-Seal™ Mechanical Nominal Pipe Shipping Assembly (PSI) Joint Gaskets are provided Size Weights* Deflection with all 1100TDM MEGALUG 4 21.6 3° 700 restraints. These are required 6 33.0 3° 700 to accommodate the pressure ratings and safety factors 8 40.0 3° 700 shown. 10 60.2 3° 700 12 75.0 3° 700 • New: High strength heavy hex 14 112.7 2° 700 machine bolts with T-nuts are 16 131.6 2° 700 provided to facilitate easier assembly due to the fittings 18 145.2 1½° 500 radius area prohibiting the use 20 166.6 1½° 500 longer T-bolts. 24 290.2 1½° 500 30 457.9 1° 500 • T-Nuts constructed of High 36 553.63 1° 500 Tensile Ductile Iron with Fluropolymer Coating. 42 1,074.8 1° 500 48 1,283.1 1° 500 For use on water or wastewater 54 1,445.32 ½° 400 pipelines subject to hydrostatic NOTE: For applications or pressures other than those shown please pressure and tested in accordance contact EBAA for assistance. -
Embryonic Cell That Forms Cartilage Medical Term
Embryonic Cell That Forms Cartilage Medical Term Unexploited Gordie languishes: he scumbles his initiatives atweel and esthetically. When Nate gestate his niggardliness Grecizing not post-free enough, is Mikhail windowless? Ship-rigged or millionth, Edgar never enshrining any millionairesses! The crest cell phenotype research in record area forms the body of shift review the Table 1. Where and repair differs substantially augments the embryonic cartilage tissue types of its tension adaptation and cells? In both types for medicine to that cartilage. Cells turn into differentiated stem cells that trace specific tissues and organs. Ambiguous cells the emergence of daughter stem a concept in. Mesenchymal Chondrosarcoma NORD National. Blood cells Chondro Oma Cartilage Tumor Arthro Joints Cartilage creates a. Can disturb blood cells and stromal which manufacture produce fat cartilage and bone. Label by following from NURSING 3345 at University of Texas Medical Branch. Body mostly a laboratory stem cells divide that form more cells called daughter cells. Guidelines for Human Embryonic Stem Cell with Brown. Abstract The skeletal system is formed of bones and cartilage which are. Each tissue cartilage bone and skeletal muscle goes through my different. Medical terms UCL. Please note love the definitions are moving given an explain another word found also a. Definition Stem cells are cells which feature not yet developed a special. The term totipotent refer down the grief that they ever total potential to. Stem from Research Uses Types & Examples Healthline. For cardiac muscle cells and was still pluripotent stem cells may also structures and cartilage that embryonic cell forms a primitive connective tissue physiology as well as macrophages are adequately informed consent. -
Case Report AJNT
Arab Journal of Nephrology and Transplantation. 2011 Sep;4(3):155-8 Case Report AJNT High Ureteric Injury Following Multiorgan Recovery: Successful Kidney Transplant with Boari Flap Ureterocystostomy Reconstruction Michael Charlesworth*, Gabriele Marangoni, Niaz Ahmad Department of Transplantation, Division of Surgery, St James’s University Hospital, Leeds, United Kingdom Abstract Keywords: Kidney; Transplant; Ureter; Donor efficiency Introduction: Despite increased utilization of marginal organs, there is still a marked disparity between organ The authors declared no conflict of interest supply and demand for transplantation. To maximize resources, it is imperative that procured organs are in Introduction good condition. Surgical damage at organ recovery can happen and organs are sometimes discarded as a result. Despite the extension of the donor pool with the inclusion We describe a damaged recovered kidney with high of marginal organs and the use of organs donated after ureteric transection that was successfully transplanted cardiac death, there is still a great disparity between the using a primary Boari flap ureterocystostomy. number of patients on the transplant waiting list and the number of kidney transplants performed each year. Case report: The donor kidney was procured form a It is therefore of paramount importance to maximize deceased donor and sustained damage by transection our scarce resources and avoid the discard of otherwise of the ureter just distal to the pelvi-ureteric junction at functional kidneys due to iatrogenic injuries at the time organ recovery. The recipient had been on the transplant of multi-organ recovery. Essentially, three types of organ waiting list for eight years and not accepting this kidney damage can potentially occur: vascular, parenchymal would have seriously jeopardized her chance of future and ureteric. -
Human Anatomy (Biology 2) Lecture Notes Updated July 2017 Instructor
Human Anatomy (Biology 2) Lecture Notes Updated July 2017 Instructor: Rebecca Bailey 1 Chapter 1 The Human Body: An Orientation • Terms - Anatomy: the study of body structure and relationships among structures - Physiology: the study of body function • Levels of Organization - Chemical level 1. atoms and molecules - Cells 1. the basic unit of all living things - Tissues 1. cells join together to perform a particular function - Organs 1. tissues join together to perform a particular function - Organ system 1. organs join together to perform a particular function - Organismal 1. the whole body • Organ Systems • Anatomical Position • Regional Names - Axial region 1. head 2. neck 3. trunk a. thorax b. abdomen c. pelvis d. perineum - Appendicular region 1. limbs • Directional Terms - Superior (above) vs. Inferior (below) - Anterior (toward the front) vs. Posterior (toward the back)(Dorsal vs. Ventral) - Medial (toward the midline) vs. Lateral (away from the midline) - Intermediate (between a more medial and a more lateral structure) - Proximal (closer to the point of origin) vs. Distal (farther from the point of origin) - Superficial (toward the surface) vs. Deep (away from the surface) • Planes and Sections divide the body or organ - Frontal or coronal 1. divides into anterior/posterior 2 - Sagittal 1. divides into right and left halves 2. includes midsagittal and parasagittal - Transverse or cross-sectional 1. divides into superior/inferior • Body Cavities - Dorsal 1. cranial cavity 2. vertebral cavity - Ventral 1. lined with serous membrane 2. viscera (organs) covered by serous membrane 3. thoracic cavity a. two pleural cavities contain the lungs b. pericardial cavity contains heart c. the cavities are defined by serous membrane d. -
Module 6 : Anatomy of the Joints
Module 6 : Anatomy of the Joints In this module you will learn: About the classification of joints What synovial joints are and how they work Where the hinge joints are located and their functions Examples of gliding joints and how they work About the saddle joint and its function 6.1 Introduction The body has a need for strength and movement, which is why we are rigid. If our bodies were not made this way, then movement would be impossible. We are designed to grow with bones, tendons, ligaments, and joints that all play a part in natural movements known as articulations – these strong connections join up bones, teeth, and cartilage. Each joint in our body makes these links possible and each joint performs a specific job – many of them differ in shape and structure, but all control a range of motion between the body parts that they connect. 6.2 Classifying Joints Joints that do not allow movement are known as synarthrosis joints. Examples of synarthroses are sutures of the skull, and the gomphoses which connect our teeth to the skull. Amphiarthrosis joints allow a small range of movement, an example of this is your intervertebral discs attached to the spine. Another example is the pubic symphysis in your hip region. The freely moving joints are classified as diarthrosis joints. These have a higher range of motion than any other type of joint, they include knees, elbows, shoulders, and wrists. Joints can also be classified depending on the kind of material each one is structurally made up of. A fibrous joint is made up of tough collagen fiber, examples of this are previously mentioned sutures of the skull or the syndesmosis joint, which holds the ulna and radius of your forearm in place. -
Chapter 14. Anthropometry and Biomechanics
Table of contents 14 Anthropometry and biomechanics........................................................................................ 14-1 14.1 General application of anthropometric and biomechanic data .....................................14-2 14.1.1 User population......................................................................................................14-2 14.1.2 Using design limits ................................................................................................14-4 14.1.3 Avoiding pitfalls in applying anthropometric data ................................................14-6 14.1.4 Solving a complex sequence of design problems ..................................................14-7 14.1.5 Use of distribution and correlation data...............................................................14-11 14.2 Anthropometric variability factors..............................................................................14-13 14.3 Anthropometric and biomechanics data......................................................................14-13 14.3.1 Data usage............................................................................................................14-13 14.3.2 Static body characteristics....................................................................................14-14 14.3.3 Dynamic (mobile) body characteristics ...............................................................14-28 14.3.3.1 Range of whole body motion........................................................................14-28 -
The Human Body Systems for Kids
1 Maine Regional School Unit #67 Chester, Lincoln, Mattawamkeag The Human Body Systems for Kids KidsKonnect.com and kidshealth.org provide links to more detailed information about each of the systems listed below. The first group of systems are commonly taught in the elementary grades. Teachers wishing more detailed information should consult sources beyond this handout. There are many systems in the human body. • Skeletal System (bones) • Respiratory System (nose, trachea, lungs) • Circulatory System (heart, blood, vessels) • Digestive System (mouth, esophogus, stomach, intestines) • Muscular System (muscles) • Nervous System (brain, spinal cord, nerves) • Excretory System (lungs, large intestine, kidneys) • Urinary System (bladder, kidneys) • Endocrine System (glands) • Reproductive System (male and female reproductive organs) • Immune System (many types of protein, cells, organs, tissues) 2 The Skeletal System has three major jobs: • It protects our vital organs such as the brain, the heart, and the lungs. • It gives us the shape that we have. • It allows us to move. Because muscles are attached to bones, when muscles move, they move the bones and the body moves. http://kidshealth.org/kid/htbw/bones.html The Respiratory System is the system of the body that deals with breathing. When we breathe, the body takes in the oxygen that it needs and removes the carbon dioxide that it doesn't need. The organ most closely connected with this system is the lung. The human body has two lungs. http://kidshealth.org/kid/htbw/lungs.html 3 The Circulatory System is the system by which oxygen and nutrients reach the body's cells, and waste materials are carried away. -
Module 2 : Anatomy – the Skeleton
Module 2 : Anatomy – The Skeleton In this module you will learn: The functions of the skeletal system The types of bones in the human body The effects of exercise on your bones What happens to the bones as we get older When studying to become a fitness instructor or personal trainer, you will learn all about the anatomy of the human body. Studying the skeleton is one of the foundations of your trade, you will need to know how the body is structured, the names of each bone, types of bones, importance of bone and joint health, detail of the spine and different terms of movement. Without stating the obvious, each of your clients has their own skeleton and you must be fully aware of how this works. This is for many reasons; you are a teacher and must be fully aware of how to prevent injuries, avoid unnecessary stress on the bones and, if qualified, help the client prevent or heal bone and joint related conditions or medical problems. 2.1 Understanding the Skeletal System The skeleton is comprised of 206 different bones that provide 5 main functions: Support mechanism for muscle and tissue Protection for organs Movement with bones, muscles, and joints Storing minerals and blood cells Growth Skeletal System 2.2 Bones are Formed by Ossification Some bones (such as the flat bones of your skull) in the body are formed in a similar stage to connective tissue. The process is known as direct or intramembranous ossification. Other bones are made up of cartilaginous matter, this is developed from future bone in the embryo which then dissolves and is replaced with other bone cells. -
The Muscular System
THE MUSCULAR SYSTEM COMPILED BY HOWIE BAUM 1 Muscles make up the bulk of the body and account for 1/3 of its weight.!! Blood vessels and nerves run to every muscle, helping control and regulate each muscle’s function. The muscular system creates body heat and also moves the: Bones of the Skeletal system Food through Digestive system Blood through the Circulatory system Fluids through the Excretory system MUSCLE TISSUE The body has 3 main types of muscle tissue 1) Skeletal, 2) Smooth, and 3) Cardiac SKELETAL MUSCLE SMOOTH MUSCLE CARDIAC MUSCLE Skeletal muscles attach to and move bones by contracting and relaxing in response to voluntary messages from the nervous system. Skeletal muscle tissue is composed of long cells called muscle fibers that have a striated appearance. Muscle fibers are organized into bundles supplied by blood vessels and innervated by motor neurons. Muscle structure Skeletal (striated or voluntary) muscle consists of densely packed groups of hugely elongated cells known as myofibers. These are grouped into bundles (fascicles). A typical myofiber is 2–3 centimeters ( 3/4–1 1/5 in) long and 0.05millimeters (1/500 inch) in diameter and is composed of narrower structures – myofibrils. These contain thick and thin myofilaments made up mainly of the proteins actin and myosin. Numerous capillaries keep the muscle supplied with the oxygen and glucose needed to fuel contraction. Skeletal Muscles • Skeletal muscles attach to bones by tendons (connective tissue) and enable movement. • Skeletal muscles are mostly voluntary Feel the back of your ankle to feel your Achilles tendon - the largest tendon in your body.