(Wechakorn) Training in Medical Care
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Somrat Vol. 11 No. 1 Page 21-32.Pmd
Asian Biomedicine Vol. 11 No. 1 February 2017; 21 - 32 DOI: 10.5372/1905-7415.1101.535 Original article Perioperative and Anesthetic Adverse events in Thailand (PAAd Thai) incident reporting study: anesthetic profiles and outcomes Somrat Charuluxananan1, Wimonrat Sriraj2, Yodying Punjasawadwong3, Siriporn Pitimana-aree4, Varinee Lekprasert5, Thewarug Werawatganon1, Wirat Wasinwong6, Prapa Ratanachai7, Dujduen Sriramatr8, Sunida Atichat9, Wanna Angkasuvan7, Chuthamat Somchat10, Duangporn Tanutanud11, Thidarat Ariyanuchitkul12, Jaroonpong Choorat13, Krairerk Sintavanuruk14, Jeratkana Janngam15 1Department of Anesthesiology, Faculty of Medicine, Chulalongkorn University, Bangkok 10330, Thailand 2Department of Anesthesiology, Faculty of Medicine, Khon Kaen University, Khon Kaen 40000, Thailand 3Department of Anesthesiology, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, Thailand 4Department of Anesthesiology, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok 10700, Thailand 5Department of Anesthesiology, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok 10400, Thailand 6Department of Anesthesiology, Faculty of Medicine, Prince of Songkla University, Songkhla 90110, Thailand 7Department of Anesthesiology, Hatyai Hospital, Songkhla 90110, Thailand 8Department of Anesthesiology, Faculty of Medicine, Srinakharinwirot University, Nakhon Nayok 26120, Thailand 9Department of Anesthesiology, Chonburi Regional Hospital, Chonburi 20000, Thailand 10Department of Anesthesiology, Lamphun Hospital, Lamphun -
Cover Tjs 35-4-57
ISSN 0125-6068 TheThai Journal of SURGERY Official Publication of the Royal College of Surgeons of Thailand www.surgeons.or.th/ejournal Volume 35 October-December 2014 Number 4 ORIGINAL ARTICLES 121 Comparison between Ventriculoatrial Shunt and Ventriculoperitoneal Shunt: Revision Rate and Complications Korrapakc Wangtanaphat, Porn Narischart 126 Open Surgical Management of Atherosclerotic Aortoiliac Occlusive Diseases (AIOD) Type 1 Anuwat Chantip 130 “Sawanpracharak” Connector: A Single Tube Intercostal Drainage Connector Wanchai Manakijsirisuthi 134 The Trainee’s Operative Experiences for General Surgery in Thailand Potchavit Aphinives CASE REPORT 139 Mitral and Tricuspid Valve Replacement in Uncommon Case of Situs Inversus with Dextrocardia Nuttapon Arayawudhikul, Boonsap Sakboon, Jareon Cheewinmethasiri, Angsu Chartirungsun, Benjamaporn Sripisuttrakul ABSTRACTS 143 Abstracts of the 39th Annual Scientific Congress of the Royal College of Surgeons of Thailand, 10-13 July 2014, Ambassador City Jomtien Hotel, Jomtien, Pattaya, Cholburi, Thailand (Part II) 169 Index Secretariat Office : Royal Golden Jubilee Building, 2 Soi Soonvijai, New Petchaburi Road, Huaykwang, Bangkok 10310, Thailand Tel. +66 2716 6141-3 Fax +66 2716 6144 E-mail: [email protected] www.surgeons.or.th The THAI Journal of SURGERY Official Publication of the Royal College of Surgeons of Thailand Vol. 35 October - December 2014 No. 4 Original Article Comparison between Ventriculoatrial Shunt and Ventriculoperitoneal Shunt: Revision Rate and Complications Korrapakc Wangtanaphat, MD Porn Narischart, MD Prasat Neurological Institute, Department of Medical Services, Ministry of Pubic Health, Bangkok, Thailand Abstract Background and Objective: Hydrocephalus is a common problem in neurosurgical field. In current clinical practice guidelines, ventriculoatrial shunt and ventriculoperitoneal shunt are recommended treatment options. No previous study reported differences between two procedures in term of complications and revision rates. -
About Pain Pharmacology: What Pain Physicians Should Know Kyung-Hoon Kim1, Hyo-Jung Seo1, Salahadin Abdi2, and Billy Huh2
Korean J Pain 2020;33(2):108-120 https://doi.org/10.3344/kjp.2020.33.2.108 pISSN 2005-9159 eISSN 2093-0569 Review Article All about pain pharmacology: what pain physicians should know Kyung-Hoon Kim1, Hyo-Jung Seo1, Salahadin Abdi2, and Billy Huh2 1Department of Anesthesia and Pain Medicine, School of Medicine, Pusan National University, Yangsan, Korea 2Department of Pain Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA Received February 8, 2020 Revised March 12, 2020 From the perspective of the definition of pain, pain can be divided into emotional Accepted March 13, 2020 and sensory components, which originate from potential and actual tissue dam- age, respectively. The pharmacologic treatment of the emotional pain component Correspondence includes antianxiety drugs, antidepressants, and antipsychotics. The anti-anxiety Kyung-Hoon Kim drugs have anti-anxious, sedative, and somnolent effects. The antipsychotics are Department of Anesthesia and Pain effective in patients with positive symptoms of psychosis. On the other hand, the Medicine, Pusan National University sensory pain component can be divided into nociceptive and neuropathic pain. Yangsan Hospital, 20 Geumo-ro, Non-steroidal anti-inflammatory drugs (NSAIDs) and opioids are usually applied for Mulgeum-eup, Yangsan 50612, Korea Tel: +82-55-360-1422 somatic and visceral nociceptive pain, respectively; anticonvulsants and antide- Fax: +82-55-360-2149 pressants are administered for the treatment of neuropathic pain with positive and E-mail: [email protected] negative symptoms, respectively. The NSAIDs, which inhibit the cyclo-oxygenase pathway, exhibit anti-inflammatory, antipyretic, and analgesic effects; however, they have a therapeutic ceiling. -
วารสาร พยาบาลสาร Nursing Journal ปีที่ 47 ฉบับที่ 1 มกราคม-มีนาคม พ.ศ
พยาบาลสาร : Nursing Journal คณะพยาบาลศาสตร์ มหาวิทยาลัยเชียงใหม่ วารสาร พยาบาลสาร Nursing Journal ปีที่ 47 ฉบับที่ 1 มกราคม-มีนาคม พ.ศ. 2563 • Volume 47 No.1 January-March 2020 ISSN 0125-5118 ที่ปรึกษา (Consultant) ศาสตราจารย์ ดร.วิภาดา คุณาวิกติกุล คณะพยาบาลศาสตร์ มหาวิทยาลัยเชียงใหม่ Wipada Kunaviktikul, PhD, RN, FAAN Faculty of Nursing, Chiang Mai University ผู้ช่วยศาสตราจารย์ ดร.จุฑารัตน์ มีสุขโข คณะพยาบาลศาสตร์ มหาวิทยาลัยเชียงใหม่ Jutarat Mesukko, PhD, RN Faculty of Nursing, Chiang Mai University ที่ปรึกษากองบรรณาธิการ (Editorial Advisors) ศาสตราจารย์เกียรติคุณ ดร.วิจิตร ศรีสุพรรณ อดีตนายกสภาการพยาบาล Wichit Srisuphan, DrPH, RN Professor ศาสตราจารย์ ดร.ประนอม โอทกานนท์ ศาสตราจารย์ Pranom Othagnont, RN, M.E.D.,Ed.D. Professor ศาสตราจารย์ ดร.สมจิต หนุเจริญกุล ศาสตราจารย์ Somchit Hanucharurnkul, PhD, RN Professo บรรณาธิการ (Editor) ศาสตราจารย์ ดร. อารีวรรณ กลั่นกลิ่น คณะพยาบาลศาสตร์ มหาวิทยาลัยเชียงใหม่ Areewan Klunklin, PhD, RN Faculty of Nursing, Chiang Mai University รองบรรณาธิการ (Associate Editor) รองศาสตราจารย์ ดร.นันทพร แสนศิริพันธ์ คณะพยาบาลศาสตร์ มหาวิทยาลัยเชียงใหม่ Nantaporn Sansiriphun, PhD, RN, APN Faculty of Nursing, Chiang Mai University กองบรรณาธิการ (Editorial Board) ศาสตราจารย์ ดร.รุจา ภู่ไพบูลย์ คณะพยาบาลศาสตร์ มหาวิทยาลัยมหิดลศาสตราจารย์ Rutja Phuphaibul, DNS, RN Faculty of Nursing, Mahidol University ศาสตราจารย์ ดร.วีณา จีระแพทย์ คณะพยาบาลศาสตร์ จุฬาลงกรณ์มหาวิทยาลัย Veena Jirapaet, PhD, RN Faculty of Nursing, Chulalongkorn University ศาสตราจารย์ ดร.วารุณี ฟองแก้ว คณะพยาบาลศาสตร์ มหาวิทยาลัยเชียงใหม่ Warunee Fongkaew, -
Blood Group Genomics
BLOOD GROUP GENOMICS Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry analysis of 36 blood group alleles among 396 Thai samples reveals region-specific variants Philaiphon Jongruamklang,1 Christoph Gassner,2 Stefan Meyer,2 Aksarakorn Kummasook,3 Marion Darlison,1 Chayanun Boonlum,4 Surin Chanta,5 Beat M. Frey,2 Martin L. Olsson,1,6* and Jill R. Storry 1,6* lood group antigen polymorphism shows great BACKGROUND: Blood group phenotype variation has variation in different world populations. The been attributed to potential resistance to pathogen reason for this is not completely understood; invasion. Variation was mapped in blood donors from however, it has been attributed to both Lampang (northern region) and Saraburi (central region), B Thailand, where malaria is endemic. The previously unknown blood group allele profiles were characterized ABBREVIATIONS: MALDI-TOF MS 5 matrix-assisted laser and the data were correlated with phenotypes. The high desorption/ionization time-of-flight mass spectrometry; PCR- incidence of the Vel-negative phenotype previously ASP 5 polymerase chain reaction with allele-specific reported in Thais was investigated. primers; SNP(s) 5 single nucleotide polymorphism(s). STUDY DESIGN AND METHODS: DNA from 396 From 1Hematology and Transfusion Medicine, Department of blood donors was analyzed by matrix-assisted laser Laboratory Medicine, Lund University, Lund, Sweden; desorption/ionization–time-of-flight mass spectrometry. 2Molecular Diagnostics & Research (MOC), Blood Transfusion Outliers were investigated by serology and DNA Service Zurich,€ Zurich-Schlieren,€ Switzerland; 3Department of sequencing. Allele discrimination assays for SMIM1 Medical Technology, School of Allied Health Sciences, rs1175550A/G and ACKR1 rs118062001C/T were University of Phayao, Phayao, Thailand; 4Transfusion Medicine, performed and correlated with antigen expression. -
Aw-Poster-Pongsak Pirom-0629
Poster #0629 HEPATITIS B VIRUS DNA LEVEL CHANGES IN HBeAg+ PREGNANT WOMEN RECEIVING TDF FOR PREVENTION OF MOTHER-TO-CHILD TRANSMISSION IRD-CMU PHPT CROIConference on Retroviruses Nicole Ngo-Giang-Huong1, Nicolas Salvadori2, Woottichai Khamduang2, Tim R. Cressey2, Linda J. Harrison3, Luc Decker1, Camlin Tierney3, Jullapong Achalapong4, and Opportunistic Infections Trudy V. Murphy5, Noele Nelson5, George K. Siberry6, Raymond T. Chung7, Stanislas Pol8, Gonzague Jourdain1, for the iTAP study group 1IRD, Chiang Mai, Thailand, 2Chiang Mai University, Chiang Mai, Thailand, 3Harvard University, Boston, MA, USA, 4Chiangrai Prachanukroh Hospital, Chiang Rai, Thailand, 5CDC, Atlanta, GA, USA, 6USAID, Arlington, VA, USA, 7Massachusetts General Hospital, Boston, MA, USA, 8Cochin Hospital, Paris, France Background HBV DNA load measurements • 12% (19 of 161) did not achieve 5.3 log10 IU/ml at delivery; References • Population: all women assigned to the TDF arm + a randomly the median (range) HBV DNA for these women was 8.3 • High hepatitis B virus (HBV) DNA levels and positive hepatitis (7.1 to 9.1) log IU/mL at baseline, 7.4 (4.7 to 8.6) at • Sarin SK, Kumar M, Lau GK, et al. Asian-Pacific clinical practice guidelines on selected subset of 50 women assigned to the placebo arm 10 B e antigen (HBeAg-an indicator of rapid viral replication and 32-weeks, 7.0 (3.9 to 8.5) at 36 weeks and 7.8 (5.3 to 8.9) the management of hepatitis B: a 2015 update. Hepatol Int 2016;10:1-98. • European Association for the Study of the Liver. Electronic address eee, high level of HBV DNA) are the main markers of risk for • Timing: at baseline (28 weeks gestation), at Weeks 32 and at delivery. -
Clinical Epidemiology of 7126 Melioidosis Patients in Thailand and the Implications for a National Notifiable Diseases Surveilla
applyparastyle “fig//caption/p[1]” parastyle “FigCapt” View metadata, citation and similar papers at core.ac.uk brought to you by CORE Open Forum Infectious Diseases provided by Apollo MAJOR ARTICLE Clinical Epidemiology of 7126 Melioidosis Patients in Thailand and the Implications for a National Notifiable Diseases Surveillance System Viriya Hantrakun,1, Somkid Kongyu,2 Preeyarach Klaytong,1 Sittikorn Rongsumlee,1 Nicholas P. J. Day,1,3 Sharon J. Peacock,4 Soawapak Hinjoy,2,5 and Direk Limmathurotsakul1,3,6, 1Mahidol-Oxford Tropical Medicine Research Unit (MORU), Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand, 2 Epidemiology Division, Department of Disease Control, Ministry of Public Health, Nonthaburi, Thailand, 3 Centre for Tropical Medicine and Global Health, Nuffield Department of Clinical Medicine, Old Road Campus, University of Oxford, Oxford, United Kingdom, 4 Department of Medicine, University of Cambridge, Cambridge, United Kingdom, 5 Office of International Cooperation, Department of Disease Control, Ministry of Public Health, Nonthaburi, Thailand, and 6 Department of Tropical Hygiene, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand Background. National notifiable diseases surveillance system (NNDSS) data in developing countries are usually incomplete, yet the total number of fatal cases reported is commonly used in national priority-setting. Melioidosis, an infectious disease caused by Burkholderia pseudomallei, is largely underrecognized by policy-makers due to the underreporting of fatal cases via the NNDSS. Methods. Collaborating with the Epidemiology Division (ED), Ministry of Public Health (MoPH), we conducted a retrospec- tive study to determine the incidence and mortality of melioidosis cases already identified by clinical microbiology laboratories nationwide. A case of melioidosis was defined as a patient with any clinical specimen culture positive for B. -
A Maternal Short Course of Tenofovir Disoproxil Fumarate and Infant Vaccine to Prevent Mother-To-Child Transmission of Hepatitis B Virus
Study Title: Antiviral prophylaxis and infant vaccination to prevent perinatal hepatitis B infection, version 1.0 dated 21 August 2017 Protocol A Maternal Short Course of Tenofovir Disoproxil Fumarate and Infant Vaccine to Prevent Mother-to-Child Transmission of Hepatitis B Virus Short title: Antiviral prophylaxis and infant vaccination to prevent perinatal hepatitis B infection Version 1.0 August 21 , 2017 Study Coordination Center: PHPT (Chiang Mai University - Institut de recherche pour Ie development Collaboration) 110 Intawaroros Rd. T. Sripoom, Muang OJ. Chiang Mai 50200 , Thailand ') , O! C:?.:' r '\ Telephone: +66 5381 9125 (up to 29) 2 1 ~ . O . ~ 2 r, 6 0 Fax: +66 53252253, +66 5381 9130 , I ..J E-mail: gon [email protected] t) · :; m :i 1J n 1.j ~lV 1i H l1 f1l 1 1 ~tJ hnJ .lI ~ tJ (~ll ,rlH~~;.r"JlFn" ~" ...x-e- -, •.,- -j ~ ' r " ':C ' ~ " lJ ~ :" • .r-« I J "J ~ " " 'it}JrJ (lYflL , Study Title: Antiviral prophylaxis and infant vaccination to prevent perinatal hepatitis 8 infection, version 1.0 dated 21 August 2017 Table of Contents 1. Study Title 4 2. Protocol team and investigators' names and contact information .4 3. Project Summary 10 4. Background information 12 4.1 Background 12 4.2 Study Rationale 14 5. Study specific objectives 15 5.1 Study objectives 15 5.2 Study Design 16 6. Study sites and duration of the study 17 6.1 Study sites 17 6.2 Duration of the study 18 7. Workplan 19 7.1 Study population 19 7.1.1 Eligibility 19 7.1.2 Inclusion criteria 19 7.1.3 Exclusion criteria 19 7.1.4 Discontinuation criteria 19 7.2 Implementation, data collection, and monitoring procedures 20 7.2.1 Follow-up and study procedures 20 7.2.2 Laboratory assessments 22 7.2.3 Data collection 22 7.2.4 Reporting 22 7.2.5 Study implementation onsite monitoring 23 7.3 Study drugs 23 7.4 Biohazard Containment 23 7.5 Statistical considerations 23 7.5.1 Justifications for the design 23 7.5.2 Endpoints 23 7.5.3 Sample size 24 7.5.4 Analyses for the primary objective 25 7.5.5 Analyses for the secondary objectives/endpoints 25 7.6 Data and Safety Monitoring Board 26 8. -
8Th Thailand Orthopaedic Trauma Annual Congress (TOTAC) 'How
8th Thailand Orthopaedic Trauma Annual Congress (TOTAC) February, 20-22, 2019 @Somdej Phra BorommaRatchathewi Na Si ‘How can we operate as an expert? Pearls and pitfalls’ Racha Hospital, Chonburi TOTAC 2019 “Trauma Night, Dinner Symposium” Feb 20,2019 Room Speaker 18.00-19.00 Fractures of the upper extremity (Thai) Panelist : Chanakarn Phornphutkul Nathapon Chantaraseno Vajarin Phiphobmongkol Surasak Jitprapaikulsarn 18.00-18.15 Fracture-Dislocation of Elbow Sanyakupta Boonperm 18.15-18.30 Neglected fracture of proximal humerus Vantawat Umprai 18.30-18.45 Complex scapular fracture Wichai Termsombatborworn 18.45-19.00 Failed plate of humeral shaft Chonlathan Iamsumang 19.00-20.00 Fractures of the lower extremity (Thai) Panelist : Apipop Kritsaneephaiboon Noratep Kulachote Vajara Phiphobmongkol Pongpol Petchkam 19.00-19.15 Complex fracture of femoral shaft Preecha Bunchongcharoenlert 19.15-19.30 Complex Tibial Plateau Fracture Sasipong Rohitotakarn 19.30-19.45 Posterior Hip Dislocation with Femoral Head Fracture Phoonyathorn Phatthanathitikarn 19.45-20.00 Complex Tibial plafond Fracture Pissanu Reingrittha Page 1 of Feb 21,2019 Room A Speaker Feb 21,2019 Room B Speaker Feb 21,2019 Room C 8.30-10.00 Module 1 : Complex tibial plateau fracture : The art of reconstruction (Thai) Moderator Likit Rugpolmuang Komkrich Wattanapaiboon 8.30-8.40 Initial management and staged approach Puripun Jirangkul 8.40-8.50 Three-column concept and preoperative planning Sorawut Thamyongkit 8.50-9.00 Single or dual implants : how to make a decision? Eakachit Sikarinkul -
Childhood Neurological Conditions and Disorders
Childhood neurological conditions and disorders Please note: We do include rare conditions. If your one is not in the list below we will still consider your survey responses. Epilepsies Autosomal dominant epilepsy with auditory features (ADEAF) Autosomal-dominant nocturnal frontal lobe epilepsy (ADNFLE) Benign epilepsy with centrotemporal spikes (BECTS) Benign familial infantile epilepsy Benign familial neonatal epilepsy (BFNE) Benign infantile epilepsy Benign neonatal seizures (BNS) Childhood absence epilepsy (CAE) Cyclin Dependent Kinase-Like 5 (CDKL5) Deficiency Disorder Dravet syndrome Early myoclonic encephalopathy (EME) Epilepsy of infancy with migrating focal seizures Epilepsy with generalized tonic–clonic seizures alone Epilepsy with myoclonic absences Epilepsy with myoclonic atonic (previously astatic) seizures Epileptic encephalopathy with continuous spike-and-wave during sleep (CSWS) Familial focal epilepsy with variable foci (childhood to adult) Febrile seizures (FS) Febrile seizures plus (FS+) (can start in infancy) Gelastic seizures with hypothalamic hamartoma Hemiconvulsion–hemiplegia–epilepsy Juvenile absence epilepsy (JAE) Juvenile myoclonic epilepsy (JME) Landau-Kleffner syndrome (LKS) Late onset childhood occipital epilepsy (Gastaut type) Lennox-Gastaut syndrome Mesial temporal lobe epilepsy with hippocampal sclerosis (MTLE with HS) Myoclonic epilepsy in infancy (MEI) Ohtahara syndrome Panayiotopoulos syndrome Photosensitive absence epilepsies including Jeavons syndrome, Sunflower syndrome Progressive myoclonus epilepsies -
1 July 2008.Pmd
Bangladesh Journal of Neuroscience 2008; Vol. 24 (1) : 9-16 Initial Neurologic Symptoms Among Bangladeshi Multiple Sclerosis Patients MD BAHADUR ALI MIAH1, ABDUL KADER SHEIKH1, AKHLAQUE HOSAIN KHAN2, MD RAFIQUL ISLAM3, AKM ANWAR ULLAH4, QUAZI DEEN MOHAMMAD5, ANISUL HAQUE4 Abstract vision (optic nerve involvement, 64%), motor This study was undertaken in the weakness (92%), sphincteric disturbances Department of Neurology, Bangabandhu (92%) and a lower rate of brainstem and Sheikh Mujib Medical University (BSMMU), cerebellar involvement. Painful tonic Dhaka, from January 2002 to December spasm was a prominent feature among 2003. The objective of this study was to Bangladeshi patients with multiple sclerosis determine the initial neurologic symptoms (8 out of 25, 32%). of multiple sclerosis among Bangladeshi Out of 25 patients, one (4%) expired due patients. to aspiration pneumonia. Twenty four (96%) A total of 25 respondents of multiple survived. Among them 9 (36%) has sclerosis patients as cases selected by restricted activity, 7 (28%) were bedridden, McDonald et al. (2001) diagnostic criteria 5 (20%) were chairbound, 2 (8%) had minor disability and were in work and 1 (4%) was for multiple sclerosis were enlisted during completely normal. the study period. The clinical details, investigations of the respondents were Introduction reviewed. Data were recorded in Multiple sclerosis (MS) is an inflammatory predesigned data collection sheet. Out of demyelinating disease of central nervous 25 cases, male patients were 12 (48%) and system (CNS) causing significant morbidity females were 13 (52%), ratio being 1:1.08. with a variable course, thought to result from Majority of the patients presented at immune response to myelin sheath with second, third and fourth decades of life. -
London Journtal of Medicine
Lond J Med: first published as 10.1136/bmj.s2-1.7.601 on 3 July 1849. Downloaded from LONDON JOURNTAL OF MEDICINE, A MONTHLY 3Ietortof tte lItbfial *(fences. i5i L JULY 1849.-No. VII. ORIGINAL COMMUNICATIONS. THE CLIMACTERIC DISEASE IN WOMEN; A PAROXYSMAL AFFECTION OCCURRING AT THE DECLINE OF THE CATAXENIA. By W. TYLER SMITH, M.D. Lond.; ectturet on Midwifery and the Diseases of Womeu in the Hunterian School of Medicine. THE Climacteric Disease has received much attention, since the appear- ance of the valuable Essay on the subject ly Sir Henry Halford, in the fourth volume of the Transactions of the College of Physicians. The Climacteric Disorder there described, consists of a sudden decline of the vital or biotic powers in advanced life, and is chiefly met with, in http://www.bmj.com/ the male sex, from the age of sixty-five and upwards, the female being comparatively exempt from its attacks. Periodicity is, however, more indelibly marked upon the female than upon the male constitution; and periodic tendencies are as distinctlv seen in the diseases, as in the functions, of the female economy. With reference to the sex, the most important climacteric or-periodic epoch, of the catamenia. This is is that of the decline epoch generally a time on 30 September 2021 by guest. Protected copyright. of anxiety, both to patients and professional men; and much care has been bestowed on the study of the access and exacerbations of organic diseases, especially of the uterine system, at this time. Still, it ap- pears to me, the specual disorder of this period, from which a variety of secondary disorders arise, has never been noticed with sufficient accu- racy, either for the purposes of diagnosis or of practice.