INTERNAL INTESTINAL FISTULAE CAUSED by AMOEBIASIS a FIRST REPORT MJCHAEL DJ Fer L.R.C.P
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Diagnosis and Treatment of Perianal Crohn Disease: NASPGHAN Clinical Report and Consensus Statement
CLINICAL REPORT Diagnosis and Treatment of Perianal Crohn Disease: NASPGHAN Clinical Report and Consensus Statement ÃEdwin F. de Zoeten, zBrad A. Pasternak, §Peter Mattei, ÃRobert E. Kramer, and yHoward A. Kader ABSTRACT disease. The first description connecting regional enteritis with Inflammatory bowel disease is a chronic inflammatory disorder of the perianal disease was by Bissell et al in 1934 (2), and since that time gastrointestinal tract that includes both Crohn disease (CD) and ulcerative perianal disease has become a recognized entity and an important colitis. Abdominal pain, rectal bleeding, diarrhea, and weight loss consideration in the diagnosis and treatment of CD. Perianal characterize both CD and ulcerative colitis. The incidence of IBD in the Crohn disease (PCD) is defined as inflammation at or near the United States is 70 to 150 cases per 100,000 individuals and, as with other anus, including tags, fissures, fistulae, abscesses, or stenosis. autoimmune diseases, is on the rise. CD can affect any part of the The symptoms of PCD include pain, itching, bleeding, purulent gastrointestinal tract from the mouth to the anus and frequently will include discharge, and incontinence of stool. perianal disease. The first description connecting regional enteritis with perianal disease was by Bissell et al in 1934, and since that time perianal INCIDENCE AND NATURAL HISTORY disease has become a recognized entity and an important consideration in the Limited pediatric data describe the incidence and prevalence diagnosis and treatment of CD. Perianal Crohn disease (PCD) is defined as of PCD. The incidence of PCD in the pediatric age group has been inflammation at or near the anus, including tags, fissures, fistulae, abscesses, estimated to be between 13.6% and 62% (3). -
An Unusual Case of Amoebic Liver Abscess Presenting with Hepatic Encephalopathy: a Case Report
Case Report An Unusual Case of Amoebic Liver Abscess Presenting with Hepatic Encephalopathy: A Case Report Anil Kumar SARDA, Rakesh MITTAL Submitted: 16 Sep 2010 Department of Surgery, Maulana Azad Medical College and Lok Nayak Accepted: 3 Jan 2011 Hospital, New Delhi 110 002, India Abstract Amoebic liver abscess (ALA) with jaundice and encephalopathy is a rare occurrence and has been recognised and studied more frequently in recent years. We present a case of massive ALA presenting with jaundice, hepatic encephalopathy, and septicaemia that was treated successfully with percutaneous drainage of the abscess, right-sided chest tube insertion, and anti-amoebic therapy. Keywords: amoebiasis, hepatic encephalopathy, hepatology, jaundice, liver abscess Introduction On chest examination, there was bilateral equal air entry. Upon investigation, haemoglobin was Amoebic liver abscess (ALA) is the most 11 g/dL, with a total leukocyte count of frequent extra-intestinal manifestation of 13 000 cells/mm3 (normal range is 4000– Entamoeba histolytica infection. It has been 11 000 cells/mm3). Liver function tests revealed reported that jaundice is uncommon and mild total serum bilirubin of 20 mg/dL, with direct in liver abscess, and some even consider the bilirubin of 15 mg/dL, serum glutamic-oxaloacetic presence of jaundice as a feature against the transaminase (SGOT) of 324 IU/L (normal level diagnosis of hepatic amoebiasis (1). The cause of is less than 40 IU/L), serum glutamic–pyruvic jaundice in a case of ALA has been hypothesised transaminase (SGPT) of 340 IU/L (normal level to result from either hepatocellular dysfunction or is less than 40 IU/L), and alkaline phosphatase intrahepatic biliary obstruction (2). -
Amebiasis Annual Report 2017
Amebiasis Annual Report 2017 Amebiasis Amebiasis is no longer a reportable disease in Louisiana. Outbreaks, however, should still be reported. Amebiasis (amoebiasis) is a parasitic infection caused by Entamoeba histolytica or Entamoeba dispar. The parasite is transmitted by the fecal-oral route, either through direct contact with feces or through the consumption of contaminated food or water. Between 80% and 90% of infected individuals develop no symptoms. For symptomatic cases, the incubation period between infection and illness can range from days to weeks. The symptoms are typically gastrointestinal issues, such as diarrhea or stomach pains. It is also possible for the parasite to spread to the liver and cause abscesses. Entamoeba histolytica can be found world-wide, but is more prevalent in tropical regions with poor sanitary conditions. In some areas with extremely adverse conditions, the prevalence can be as high as 50% in the population. There are no recent data on prevalence of amebiasis in the U.S. however, prevalence is estimated to be between 1% and 4% of the population. High risk groups are refugees, recent immigrants, travelers (particularly those who have spent long periods of time in an endemic area), institutionalized people (particularly developmentally or mentally-impaired people), and men who have sex with men. The number of cases reported within Louisiana is usually low. There are typically less than ten cases per year with a few exceptions (Figure 1). Figure 1: Amebiasis cases - Louisiana, 1970-2017 40 35 30 25 20 15 Number of Cases Number 10 5 0 70 72 74 76 78 80 82 84 86 88 90 92 94 96 98 00 02 04 06 08 10 12 14 16 Year Louisiana Office of Public Health – Infectious Disease Epidemiology Section Page 1 of 4 Amebiasis Annual Report 2017 Hospitalization Hospitalization surveillance is based on Louisiana Hospital Inpatient Discharge Data (LaHIDD). -
Esophago-Pulmonary Fistula Caused by Lung Cancer Treated with a Covered Self-Expandable Metallic Stent
Abe et al. J Clin Gastroenterol Treat 2016, 2:038 Volume 2 | Issue 4 Journal of ISSN: 2469-584X Clinical Gastroenterology and Treatment Clinical Image: Open Access Esophago-Pulmonary Fistula Caused by Lung Cancer Treated with a Covered Self-Expandable Metallic Stent Takashi Abe1, Takayuki Nagai1 and Kazunari Murakami2 1Department of Gastroenterology, Oita Kouseiren Tsurumi Hospital, Japan 2Department of Gastroenterology, Oita University, Japan *Corresponding author: Takashi Abe M.D., Ph.D., Department of Gastroenterology, Oita Kouseiren Tsurumi Hospital, Tsurumi 4333, Beppu City, Oita 874-8585, Japan, Tel: +81-977-23-7111 Fax: +81-977-23-7884, E-mail: [email protected] Keywords Esophagus, Pulmonary parenchyma, Fistula, lung cancer, Self- expandable metallic stent A 71-year-old man was diagnosed with squamous cell lung cancer in the right lower lobe. He was treated with chemotherapy (first line: TS-1/CDDP; second line: carboplatin/nab-paclitaxel) and radiation therapy (41.4 Gy), but his disease continued to progress. The patient complained of relatively sudden-onset chest pain and high-grade fever. Computed tomography (CT) showed a small volume of air in the lung cancer of the right lower lobe, so the patient was suspected of fistula between the esophagus and the lung parenchyma. Upper gastrointestinal endoscopy revealed an esophageal fistula (Figure 1), which esophagography using water- soluble contrast medium showed overlying the right lower lobe Figure 2: Esophagography findings. Contrast medium is shown overlying the right lower lobe (arrow). (Figure 2). The distance from the incisor teeth to this fistula was 28 cm endoscopically. CT, which was done after esophagography, showed fistulous communication between the esophagus and Figure 1: Endoscopy showing esophageal fistula (arrow). -
Colo-Gastric Fistula As an Uncommon Complication of Crohn's Disease
Colo-gastric Fistula as an Uncommon Complication of Crohn’s Disease Molly Stone, MD September 28, 2019 Background - Crohn’s Disease (CD): a transmural inflammatory process which often gives rise to sinus tracts and eventually fistulization into adjacent serosa. - Fistulizing disease is a common complication of CD - Risk increases with longer disease duration - Prevalence of 15% in childhood; up to 50% at 20 yrs from dx - Fistulas most commonly form in perianal region - Intra-abdominal fistula develop in approximately 30% of patients. Common Sites of Fistulas Torres. The Lancet. 2017. Gastrocolic Fistula - First described in 1775, first case related to Crohn’s Disease reported in 1948 - Most commonly seen with peptic ulcer disease, cases also noted in gastric and colon cancers in addition to Crohn’s. - Classic Triad: diarrhea, weight loss, feculent emesis - Only present in 30% of cases - Presence of feculent emesis helps to distinguish gastrocolic from more distal entero-enteric fistulas Epidemiology - Rare complication noted in only 0.6% of CD pt - Youngest reported case in a 13 yo pt who had CD for 3 yrs, however most pts range 25-60 with disease duration >10 yrs - M=F - Predisposing factors: Ileal disease and prior ileocolic anastomoses Pathogenesis - Most form from mid- to distal transverse colon to the greater curvature of the stomach - Initiate from active area of colitis - Multiple cases with evidence of proximal disease on resection implying gastric to colic or bidirectional formation Greenstein, Diseases of Colon and Rectum. 1989. -
Surveillance Study of Acute Gastroenteritis Etiologies in Hospitalized Children in South Lebanon (SAGE Study)
pISSN: 2234-8646 eISSN: 2234-8840 https://doi.org/10.5223/pghn.2018.21.3.176 Pediatr Gastroenterol Hepatol Nutr 2018 July 21(3):176-183 Original Article PGHN Surveillance Study of Acute Gastroenteritis Etiologies in Hospitalized Children in South Lebanon (SAGE study) Ghassan Ghssein, Ali Salami, Lamis Salloum, Pia Chedid*, Wissam H Joumaa, and Hadi Fakih† Rammal Hassan Rammal Research Laboratory, Physio-toxicity (PhyTox) Research Group, Lebanese University, Faculty of Sciences (V), Nabatieh, *Department of Medical Laboratory Sciences, Faculty of Health Sciences, University of Balamand, †Department of Pediatrics, Faculty of Medical Sciences, Lebanese University, Beirut, Lebanon Purpose: Acute gastroenteritis (AGE) is a major cause of morbidity and remains a major cause of hospitalization. Following the Syrian refugee crisis and insufficient clean water in the region, this study reviews the etiological and epidemiological data in Lebanon. Methods: We prospectively analyzed demographic, clinical and routine laboratory data of 198 children from the age of 1 month to 10 years old who were admitted with the diagnosis of AGE to a private tertiary care hospital located in the district of Nabatieh in south Lebanon. Results: Males had a higher incidence of AGE (57.1%). Pathogens were detected in 57.6% (n=114) of admitted pa- tients, among them single pathogens were found in 51.0% (n=101) of cases that consisted of: Entamoeba histolytica 26.3% (n=52), rotavirus 18.7% (n=37), adenovirus 6.1% (n=12) and mixed co-pathogens found in 6.6% (n=13). Breast-fed children were significantly less prone to rotavirus (p=0.041). Moreover, children who had received the rota- virus vaccine were significantly less prone to rotavirus (p=0.032). -
Clinical Practice Guideline for the Management of Anorectal Abscess, Fistula-In-Ano, and Rectovaginal Fistula Jon D
PRACTICE GUIDELINES Clinical Practice Guideline for the Management of Anorectal Abscess, Fistula-in-Ano, and Rectovaginal Fistula Jon D. Vogel, M.D. • Eric K. Johnson, M.D. • Arden M. Morris, M.D. • Ian M. Paquette, M.D. Theodore J. Saclarides, M.D. • Daniel L. Feingold, M.D. • Scott R. Steele, M.D. Prepared on behalf of The Clinical Practice Guidelines Committee of the American Society of Colon and Rectal Surgeons he American Society of Colon and Rectal Sur- and submucosal locations.7–11 Anorectal abscess occurs geons is dedicated to ensuring high-quality pa- more often in males than females, and may occur at any Ttient care by advancing the science, prevention, age, with peak incidence among 20 to 40 year olds.4,8–12 and management of disorders and diseases of the co- In general, the abscess is treated with prompt incision lon, rectum, and anus. The Clinical Practice Guide- and drainage.4,6,10,13 lines Committee is charged with leading international Fistula-in-ano is a tract that connects the perine- efforts in defining quality care for conditions related al skin to the anal canal. In patients with an anorec- to the colon, rectum, and anus by developing clinical tal abscess, 30% to 70% present with a concomitant practice guidelines based on the best available evidence. fistula-in-ano, and, in those who do not, one-third will These guidelines are inclusive, not prescriptive, and are be diagnosed with a fistula in the months to years after intended for the use of all practitioners, health care abscess drainage.2,5,8–10,13–16 Although a perianal abscess workers, and patients who desire information about the is defined by the anatomic space in which it forms, a management of the conditions addressed by the topics fistula-in-ano is classified in terms of its relationship to covered in these guidelines. -
Amoebic Colitis Presenting As Subacute Intestinal Obstruction with Perforation
International Journal of TROPICAL DISEASE & Health 41(16): 58-62, 2020; Article no.IJTDH.61831 ISSN: 2278–1005, NLM ID: 101632866 Amoebic Colitis Presenting as Subacute Intestinal Obstruction with Perforation Renuka Verma1, Archana Budhwar1*, Priyanka Rawat1, Niti Dalal1, Anjali Bishlay1 and Sunita Singh1 1Pt. B. D. Sharma Post Graduate Institute of Medical Sciences, Rohtak-124001, Haryana, India. Authors’ contributions This work was carried out in collaboration among all authors. Authors RV and SS designed the study, reviewed the manuscript and edited it. Author Archana Budhwar wrote the protocol and wrote the first draft of the manuscript. Author PR managed the literature searches. Authors ND and Anjali Bishlay managed the analyses of the study. All authors read and approved the final manuscript. Article Information DOI: 10.9734/IJTDH/2020/v41i1630367 Editor(s): (1) Dr. Giuseppe Murdaca, University of Genoa, Italy. Reviewers: (1) Ammar M. Al-Aalim, Mosul University, Iraq. (2) Tarunbir Singh, Guru Angad Dev Veterinary & Animal Sciences University, Ludhiana. Complete Peer review History: http://www.sdiarticle4.com/review-history/61831 Received 10 August 2020 Case Study Accepted 16 October 2020 Published 12 November 2020 ABSTRACT Infestation with Entamoeba histolytica is worldwide, especially in developing areas. Presented case study included amoebic colitis in a 45 years old man complaining of abdominal distension and non- passage of stools since three days. Abdominal region was diffusely distended and tender in right iliac fossa. Plain abdominal radiography revealed prominent gut loops and minimal intergut free fluid. At laparotomy, malrotation of gut was present. Histopathological examination of intestinal samples confirmed final diagnosis of amoebic colitis post-operatively. -
Incidental Cholecystojejunal Fistula: a Rare Complication of Gall Stone Disease
MedCrave Online Journal of Surgery Case Report Open Access Incidental cholecystojejunal fistula: a rare complication of gall stone disease Abstract Volume 8 Issue 4 - 2020 Cholecystoenteric fistula is a rare complication of gallstone disease and difficult to diagnose Vipul K Srivastava,1 Shilpi Roy,1 Ramniwas preoperatively. Among Cholecystoenteric fistula, cholecystojejunal fistulae are even rarer Meena,2 Rahul Khanna2 and only a few case reports have been published on it. Here we report a case of a 60-year 1Resident, Department of General Surgery, Institute of Medical male patient with cholecystojejunal fistula diagnosed intraoperatively while performing Sciences, India laparoscopic cholecystectomy. Fundus of the gall bladder was found to be communicating 2Professor, Department of General Surgery, Institute of Medical with proximal jejunum. We conclude that in elderly patients if the ultrasonography shows Sciences, India features of contracted gall bladder in presence of large gall stones one should consider an option of getting a computed tomography scan done preoperatively. Correspondence: Dr. Ramniwas Meena, Professor Department of General Surgery, Institute of Medical Sciences Banaras Hindu University, Varanasi–221005, UP, India, Keywords: cholecystoenteric, cholecystojejunal, fistula, gall-stones, cholecystitis Tel +919935141697, Email Received: October 25, 2020 | Published: December 17, 2020 Introduction Cholecystoenteric fistula (CEF) was first described by Courvoisier in 1890. They are a rare complication of gallstone disease and are formed due to ongoing inflammation.1 They are bilioenteric type of Internal Biliary fistula which is rare to find. Preoperative diagnosis of CEF is difficult to make with pneumobilia being the most common radiological finding.2 So here we report a rare case of cholecystojejunal fistula. -
Improved Genomic Assembly and Genomic Analyses of Entamoeba Histolytica
Improved genomic assembly and genomic analyses of Entamoeba histolytica Thesis submitted in accordance with the requirements of the University of Liverpool for the degree of Doctor in Philosophy by Amber Leckenby September 2018 Acknowledgements There are many people without whom this thesis would not have been possible. The list is long and I am truly grateful to each and every one. Firstly I have to thank my supervisors Gareth, Christiane, Neil and Steve for the continuous support throughout my PhD. Particularly, I am grateful to Gareth and Christiane, for their patience, motivation and immense knowledge that helped me through the entirety of the proJect from the initial research to the writing of this thesis. I cannot have imagined having better mentors and role models. I also have to thank the staff at the CGR for their role in the sequencing aspects of this thesis. My further thanks extend to the CGR bioinformatics team, most notably Richard, Matthew, Sam and Luca, for not only tolerating the number of bioinformatics questions I have asked them, but also providing great friendship and warmth in the office. I must also give a special mention to Graham Clark at the London School of Hygiene and Tropical Medicine for sending cultures of Entamoeba and providing general advice, especially around the tRNA arrays. I would also like to thank David Starns, for his efforts troubleshooting the Companion pipeline and to Laura Gardiner for providing advice around all things methylation. My gratitude goes to the members of the many offices I have moved around during my PhD, many of which have become close friends who have got me through many bioinformatics conundrums, lab meltdowns and (some equally challenging) gym sessions. -
Discharge Instructions After Fistulotomy
FAIRFAX COLON & RECTAL SURGERY, P.C. DONALD B. COLVIN, M.D., F.A.S.C.R.S. PAUL E. SAVOCA, M.D., F.A.S.C.R.S. LYNDA S. DOUGHERTY, M.D., F.A.S.C.R.S. DANIEL P. OTCHY, M.D., F.A.S.C.R.S. LAWRENCE E. STERN, M.D., F.A.S.C.R.S. KIMBERLY A. MATZIE, M.D., F.A.C.S. COLORECTAL/ANORECTAL SURGERY, COLONOSCOPY, ANORECTAL PHYSIOLOGY (703) 280-2841 DISCHARGE INSTRUCTIONS AFTER FISTULOTOMY An anal fistula is an abnormal channel or tunnel-like chronic infection that starts inside the anus and ends outside on the skin around the anus. Its development is usually the result of a previous anal infection or abscess. About 50% of people with an anal abscess end up with a fistula. Most fistulas are short and superficial and are best treated by simply opening the entire tunnel and leaving it open to heal in gradually. Occasionally a patient can have a complex fistula with multiple tracts or the tunnel may traverse a considerable amount of the sphincter muscle. For this reason the surgical treatment has to be individualized for each particular patient depending on the location and anatomy of the fistula. Frequently, the surgeon cannot guarantee exactly what will need to be done until the examination that is done under anesthesia at the time of the surgery. It is important to realize that the operative procedure can change depending on what is found at the time of the surgery. At times a fistula will require more than one surgery to cure. -
What Is Enterocutaneous Fistula?
Patient Education What Is Enterocutaneous Fistula? An enterocutaneous fistula is an opening from the intestines to the top of the skin that leaks fluids or stool. This liquid usually comes from your stomach or intestines. How do I know if I have Enterocutaneous Fistula? Symptoms of an enterocutaneous fistula include: • Intestinal fluid or stool leaking through and onto the skin (seen as drainage coming from the stomach). • The stomach becomes unable to absorb nutrients (malabsorption). • Dehydration (not drinking enough water). What causes Enterocutaneous Fistula? • Problems from abdominal surgery • Trauma resulting from penetrating wounds (such as stabbings or gunshot) • Inflammatory disorders (Crohn’s disease) • Side effect of radiation to the abdomen or pelvis (can occur years after treatment) How can I fix it? Treatment for an enterocutaneous fistula depends on the size, location, patient’s history, cause of fistula, and problems related to the fistula. At times an enterocutaneous fistula closes on its own after a few weeks to months. If problems happen and/or the fistula does not heal on its own after a couple of months surgery will be needed. If the enterocutaneous fistula is draining a large amount of gastrointestinal (stomach and intestinal) fluid, the fistula is managed as a stoma (an opening in the belly for getting rid of wastes). The use of an ostomy device may also be used. Sometimes patients may need nutritional support with TPN (intravenous source of nutrition). How can I learn more? You can also find information through the American Society of Colon & Rectal Surgeons (ASCRS) at http://www.fascrs.org/patients/conditions/ Do you have any questions or comments for your doctor? _________________________________ ____ ____________________________________ PTED#0000118 Division of Colon & Rectal Surgery.