Clinical Practice Guideline for the Management of Anorectal Abscess, Fistula-In-Ano, and Rectovaginal Fistula Jon D
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Diagnosis and Treatment of Perianal Crohn Disease: NASPGHAN Clinical Report and Consensus Statement
CLINICAL REPORT Diagnosis and Treatment of Perianal Crohn Disease: NASPGHAN Clinical Report and Consensus Statement ÃEdwin F. de Zoeten, zBrad A. Pasternak, §Peter Mattei, ÃRobert E. Kramer, and yHoward A. Kader ABSTRACT disease. The first description connecting regional enteritis with Inflammatory bowel disease is a chronic inflammatory disorder of the perianal disease was by Bissell et al in 1934 (2), and since that time gastrointestinal tract that includes both Crohn disease (CD) and ulcerative perianal disease has become a recognized entity and an important colitis. Abdominal pain, rectal bleeding, diarrhea, and weight loss consideration in the diagnosis and treatment of CD. Perianal characterize both CD and ulcerative colitis. The incidence of IBD in the Crohn disease (PCD) is defined as inflammation at or near the United States is 70 to 150 cases per 100,000 individuals and, as with other anus, including tags, fissures, fistulae, abscesses, or stenosis. autoimmune diseases, is on the rise. CD can affect any part of the The symptoms of PCD include pain, itching, bleeding, purulent gastrointestinal tract from the mouth to the anus and frequently will include discharge, and incontinence of stool. perianal disease. The first description connecting regional enteritis with perianal disease was by Bissell et al in 1934, and since that time perianal INCIDENCE AND NATURAL HISTORY disease has become a recognized entity and an important consideration in the Limited pediatric data describe the incidence and prevalence diagnosis and treatment of CD. Perianal Crohn disease (PCD) is defined as of PCD. The incidence of PCD in the pediatric age group has been inflammation at or near the anus, including tags, fissures, fistulae, abscesses, estimated to be between 13.6% and 62% (3). -
Plugs for Anal Fistula Repair Original Policy Date: November 26, 2014 Effective Date: January 1, 2021 Section: 7.0 Surgery Page: Page 1 of 12
Medical Policy 7.01.123 Plugs for Anal Fistula Repair Original Policy Date: November 26, 2014 Effective Date: January 1, 2021 Section: 7.0 Surgery Page: Page 1 of 12 Policy Statement Biosynthetic fistula plugs, including plugs made of porcine small intestine submucosa or of synthetic material, are considered investigational for the repair of anal fistulas. NOTE: Refer to Appendix A to see the policy statement changes (if any) from the previous version. Policy Guidelines There is a specific CPT code for the use of these plugs in the repair of an anorectal fistula: • 46707: Repair of anorectal fistula with plug (e.g., porcine small intestine submucosa [SIS]) Description Anal fistula plugs (AFPs) are biosynthetic devices used to promote healing and prevent the recurrence of anal fistulas. They are proposed as an alternative to procedures including fistulotomy, endorectal advancement flaps, seton drain placement, and use of fibrin glue in the treatment of anal fistulas. Related Policies • N/A Benefit Application Benefit determinations should be based in all cases on the applicable contract language. To the extent there are any conflicts between these guidelines and the contract language, the contract language will control. Please refer to the member's contract benefits in effect at the time of service to determine coverage or non-coverage of these services as it applies to an individual member. Some state or federal mandates (e.g., Federal Employee Program [FEP]) prohibits plans from denying Food and Drug Administration (FDA)-approved technologies as investigational. In these instances, plans may have to consider the coverage eligibility of FDA-approved technologies on the basis of medical necessity alone. -
Surgery for Colon and Rectal Cancer
Colon and Rectal Surgery Mohammed Bayasi, MD Department of Surgery Colon and Rectal Surgery What is a Colon and Rectal Surgeon? • Fully trained General Surgeon. • Has done additional training in the diseases of colon and rectum. Why Colon and Rectal Surgery? • Surgical and non surgical therapy for multiple diseases. • Chance to help cancer patients by removing tumor, potentially curing them. • Variety of cases, ages and patient populations. • Specialized area. Colorectal Diseases • Colon • Rectum/Anus – Cancer – Hemorrhoids – Diverticulitis – Anal fistula and – Inflammatory Bowel abscess Disease (Crohn, UC) – Anal fissure – Polyps – Prolapse Symptoms/Signs • Pain • Itching • Discharge • Bleeding • Lump Anatomy Lesson Colon • Extracts water and nutrients. • Helps to form and excrete waste. • Stores important bacteria flora. • Length: 1.5 meters long = 4.9 feet = 59 inches Colon Rectum/Anus • The final portion of the colon. • Area contains muscles important in controlling defecation and flatulence. Rectum/Anus When to see a Colon and Rectal Surgeon • Referral from another physician (Gastroenterology, PCP). • Treatment of anorectal diseases. • Blood with stool, abdominal pain, rectal pain. Hemorrhoids • Internal and external. • Cushions of blood vessels. • When enlarged, they cause bleeding and pain. Treatment • Treatment of symptomatic hemorrhoids is directed by the symptoms themselves. It can broadly be categorized into four groups: − Medical therapy − Office-based procedure − Operative therapies − Emergent interventions Anorectal Abscess • It is a collection of pus in the perianal area. Normal • Causes pain and rectal gland drainage, and if it progresses, fever and systemic Abscess infection. • Treated with incision and drainage. Anorectal Fistula • A tunnel between the inside of the anus and the skin. • Causes discharge, pain, and formation of abscess. -
VOLATILE COMPOUNDS from ANAL GLANDS of the WOLVERINE, Gulo Gulo
Journal of Chemical Ecology, Vol. 12, No. 9, September 2005 ( #2005) DOI: 10.1007/s10886-005-6080-9 VOLATILE COMPOUNDS FROM ANAL GLANDS OF THE WOLVERINE, Gulo gulo WILLIAM F. WOOD,1,* MIRANDA N. TERWILLIGER,2 and JEFFREY P. COPELAND3 1Department of Chemistry, Humboldt State University, Arcata, CA 95521, USA 2Alaska Cooperative Fish & Wildlife Research Unit, Department of Biology & Wildlife, University of Alaska, Fairbanks, AK 99775, USA 3USDA Forest Service, Rocky Mountain Research Station, Missoula, MT 59801, USA (Received February 12, 2005; revised March 24, 2005; accepted April 20, 2005) Abstract—Dichloromethane extracts of wolverine (Gulo gulo, Mustelinae, Mustelidae) anal gland secretion were examined by gas chromatographyYmass spectrometry. The secretion composition was complex and variable for the six samples examined: 123 compounds were detected in total, with the number per animal ranging from 45 to 71 compounds. Only six compounds were common to all extracts: 3-methylbutanoic acid, 2-methylbutanoic acid, phenylacetic acid, a-tocopherol, cholesterol, and a compound tentatively identified as 2-methyldecanoic acid. The highly odoriferous thietanes and dithiolanes found in anal gland secretions of some members of the Mustelinae [ferrets, mink, stoats, and weasels (Mustela spp.) and zorillas (Ictonyx spp.)] were not observed. The composition of the wolverine’s anal gland secretion is similar to that of two other members of the Mustelinae, the pine and beech marten (Martes spp.). Key WordsVWolverine, Gulo gulo, Mustelinae, Mustelidae, scent marking, fear-defense mechanism, short-chain carboxylic acids. INTRODUCTION The wolverine (Gulo gulo) is the largest terrestrial member of the Mustelidae and is part of the subfamily, Mustelinae, which includes ferrets, fishers, martens, mink, stoats, weasels, and zorillas. -
Common Anorectal Conditions
TurkJMedSci 34(2004)285-293 ©TÜB‹TAK PERSPECTIVESINMEDICALSCIENCES CommonAnorectalConditions PravinJ.GUPTA ConsultingProctologistGuptaNursingHome,D/9,Laxminagar,NAGPUR-440022INDIA Received:July12,2004 Anorectaldisordersincludeadiversegroupof dentateorpectinatelinedividesthesquamousepithelium pathologicdisordersthatgeneratesignificantpatient fromthemucosalorcolumnarepithelium.Fourtoeight discomfortanddisability.Althoughthesearefrequently analglandsdrainintothecryptsofMorgagniatthelevel encounteredingeneralmedicalpractice,theyoften ofthedentateline.Mostrectalabscessesandfistulae receiveonlycasualattentionandtemporaryrelief . originateintheseglands.Thedentatelinealsodelineates Diseasesoftherectumandanusarecommon theareawheresensoryfibersend.Abovethedentate phenomena.Theirprevalenceinthegeneralpopulationis line,therectumissuppliedbystretchnervefibers,and probablymuchhigherthanthatseeninclinicalpractice, notpainnervefibers.Thisallowsmanysurgical sincemostpatientswithsymptomsreferabletothe procedurestobeperformedwithoutanesthesiaabovethe anorectumdonotseekmedicalattention. dentateline.Conversely,belowthedentateline,thereis extremesensitivity,andtheperianalareaisoneofthe Asdoctorsoffirstcontact,general(family) mostsensitiveareasofthebody.Theevacuationofbowel practitioners(GPs)frequentlyfacedifficultquestions contentsdependsonactionbythemusclesofboththe concerningtheoptimummanagementofanorectal involuntaryinternalsphincterandthevoluntaryexternal symptoms.Whiletheexaminationanddiagnosisof sphincter. certainanorectaldisorderscanbechallenging,itisa -
Preoperative Skin Antisepsis with Chlorhexidine Gluconate Versus Povidone-Iodine: a Prospective Analysis of 6959 Consecutive Spinal Surgery Patients
CLINICAL ARTICLE J Neurosurg Spine 28:209–214, 2018 Preoperative skin antisepsis with chlorhexidine gluconate versus povidone-iodine: a prospective analysis of 6959 consecutive spinal surgery patients George M. Ghobrial, MD, Michael Y. Wang, MD, Barth A. Green, MD, Howard B. Levene, MD, PhD, Glen Manzano, MD, Steven Vanni, DO, DC, Robert M. Starke, MD, MSc, George Jimsheleishvili, MD, Kenneth M. Crandall, MD, Marina Dididze, MD, PhD, and Allan D. Levi, MD, PhD Department of Neurological Surgery and The Miami Project to Cure Paralysis, University of Miami Miller School of Medicine, Miami, Florida OBJECTIVE The aim of this study was to determine the efficacy of 2 common preoperative surgical skin antiseptic agents, ChloraPrep and Betadine, in the reduction of postoperative surgical site infection (SSI) in spinal surgery proce- dures. METHODS Two preoperative surgical skin antiseptic agents—ChloraPrep (2% chlorhexidine gluconate and 70% iso- propyl alcohol) and Betadine (7.5% povidone-iodine solution)—were prospectively compared across 2 consecutive time periods for all consecutive adult neurosurgical spine patients. The primary end point was the incidence of SSI. RESULTS A total of 6959 consecutive spinal surgery patients were identified from July 1, 2011, through August 31, 2015, with 4495 (64.6%) and 2464 (35.4%) patients treated at facilities 1 and 2, respectively. Sixty-nine (0.992%) SSIs were observed. There was no significant difference in the incidence of infection between patients prepared with Beta- dine (33 [1.036%] of 3185) and those prepared with ChloraPrep (36 [0.954%] of 3774; p = 0.728). Neither was there a significant difference in the incidence of infection in the patients treated at facility 1 (52 [1.157%] of 4495) versus facility 2 (17 [0.690%] of 2464; p = 0.06). -
Esophago-Pulmonary Fistula Caused by Lung Cancer Treated with a Covered Self-Expandable Metallic Stent
Abe et al. J Clin Gastroenterol Treat 2016, 2:038 Volume 2 | Issue 4 Journal of ISSN: 2469-584X Clinical Gastroenterology and Treatment Clinical Image: Open Access Esophago-Pulmonary Fistula Caused by Lung Cancer Treated with a Covered Self-Expandable Metallic Stent Takashi Abe1, Takayuki Nagai1 and Kazunari Murakami2 1Department of Gastroenterology, Oita Kouseiren Tsurumi Hospital, Japan 2Department of Gastroenterology, Oita University, Japan *Corresponding author: Takashi Abe M.D., Ph.D., Department of Gastroenterology, Oita Kouseiren Tsurumi Hospital, Tsurumi 4333, Beppu City, Oita 874-8585, Japan, Tel: +81-977-23-7111 Fax: +81-977-23-7884, E-mail: [email protected] Keywords Esophagus, Pulmonary parenchyma, Fistula, lung cancer, Self- expandable metallic stent A 71-year-old man was diagnosed with squamous cell lung cancer in the right lower lobe. He was treated with chemotherapy (first line: TS-1/CDDP; second line: carboplatin/nab-paclitaxel) and radiation therapy (41.4 Gy), but his disease continued to progress. The patient complained of relatively sudden-onset chest pain and high-grade fever. Computed tomography (CT) showed a small volume of air in the lung cancer of the right lower lobe, so the patient was suspected of fistula between the esophagus and the lung parenchyma. Upper gastrointestinal endoscopy revealed an esophageal fistula (Figure 1), which esophagography using water- soluble contrast medium showed overlying the right lower lobe Figure 2: Esophagography findings. Contrast medium is shown overlying the right lower lobe (arrow). (Figure 2). The distance from the incisor teeth to this fistula was 28 cm endoscopically. CT, which was done after esophagography, showed fistulous communication between the esophagus and Figure 1: Endoscopy showing esophageal fistula (arrow). -
Monitoring Wolverines in Northeast Oregon
Monitoring Wolverines in Northeast Oregon January 2011 – December 2012 Final Report Authors: Audrey J. Magoun Patrick Valkenburg Clinton D. Long Judy K. Long Submitted to: The Wolverine Foundation, Inc. February 2013 Cite as: A. J. Magoun, P. Valkenburg, C. D. Long, and J. K. Long. 2013. Monitoring wolverines in northeast Oregon. January 2011 – December 2012. Final Report. The Wolverine Foundation, Inc., Kuna, Idaho. [http://wolverinefoundation.org/] Copies of this report are available from: The Wolverine Foundation, Inc. [http://wolverinefoundation.org/] Oregon Department of Fish and Wildlife [http://www.dfw.state.or.us/conservationstrategy/publications.asp] Oregon Wildlife Heritage Foundation [http://www.owhf.org/] U. S. Forest Service [http://www.fs.usda.gov/land/wallowa-whitman/landmanagement] Major Funding and Logistical Support The Wolverine Foundation, Inc. Oregon Department of Fish and Wildlife Oregon Wildlife Heritage Foundation U. S. Forest Service U. S. Fish and Wildlife Service Wolverine Discovery Center Norcross Wildlife Foundation Seattle Foundation Wildlife Conservation Society National Park Service 2 Special thanks to everyone who provided contributions, assistance, and observations of wolverines in the Wallowa-Whitman National Forest and other areas in Oregon. We appreciate all the help and interest of the staffs of the Oregon Department of Fish and Wildlife, Oregon Wildlife Heritage Foundation, U. S. Forest Service, U. S. Fish and Wildlife Service, Wildlife Conservation Society, and the National Park Service. We also thank the following individuals for their assistance with the field work: Jim Akenson, Holly Akenson, Malin Aronsson, Norma Biggar, Ken Bronec, Steve Bronson, Roblyn Brown, Vic Coggins, Alex Coutant, Cliff Crego, Leonard Erickson, Bjorn Hansen, Mike Hansen, Hans Hayden, Tim Hiller, Janet Hohmann, Pat Matthews, David McCullough, Glenn McDonald, Jamie McFadden, Kendrick Moholt, Mark Penninger, Jens Persson, Lynne Price, Brian Ratliff, Jamie Ratliff, John Stephenson, John Wyanens, Rebecca Watters, Russ Westlake, and Jeff Yanke. -
Incision & Drainage Informed Consent
Jeri Shuster, M.D., P.A. and Women’s Center, Inc. JERI SHUSTER, M.D., PA & WOMEN’SJeri Shuster, CENTER, INC M.D.,. P.A. Jeri Shuster, M.D., Fellowand of the Women’s American CollegeCenter, Obstetricians Inc. and Gynecologists Kathryn Cervi, C.R.N.P., Women’s Health Care Nurse Practitioner Jeri Shuster, M.D., Fellow of the American College Obstetricians and Gynecologists INFORMED CONSENT: Kathryn INCISION Cervi, C.R.N.P., AND Women’s DRAINAGE Health (I Care & D) Nurse Practitioner I hereby request and authorize Dr. to Jeri Shuster perform upon me the procedure: incision and drainage of _________________________________________________________________________ _____________________________________________________________________________________________ This procedure involves making an incision, either with a scalpel or with an electrical device, in order to enable fluid to drain from an area of the body. The procedure is intended to drain a cyst(s), abscess(es), or infected tissue. Risks include: bleeding, infection, burn injury, pain, scarring, failure to diagnose or cure the underlying condition, persistence or recurrence of the condition. To reduce risk of infection, after the procedure keep area as clean and dry as possible. Wash three times each day with lukewarm water and mild soap. Dry by gently dabbing with a soft wel to or carefully use a blow dryer on the cool setting. Follow each wash/dry with antibacterial ointment (such as Neosporin or Bacitracin). If genital incision and drainage ou is performed, y may also place antibiotic ointment onto cotton balls (not cosmetic puffs) to cover the wounds during urination or bowel movements. Benefits may include achieving a diagnosis (by distinguishing between a cyst and an abscss) and alleviating symptoms such as pain. -
Colo-Gastric Fistula As an Uncommon Complication of Crohn's Disease
Colo-gastric Fistula as an Uncommon Complication of Crohn’s Disease Molly Stone, MD September 28, 2019 Background - Crohn’s Disease (CD): a transmural inflammatory process which often gives rise to sinus tracts and eventually fistulization into adjacent serosa. - Fistulizing disease is a common complication of CD - Risk increases with longer disease duration - Prevalence of 15% in childhood; up to 50% at 20 yrs from dx - Fistulas most commonly form in perianal region - Intra-abdominal fistula develop in approximately 30% of patients. Common Sites of Fistulas Torres. The Lancet. 2017. Gastrocolic Fistula - First described in 1775, first case related to Crohn’s Disease reported in 1948 - Most commonly seen with peptic ulcer disease, cases also noted in gastric and colon cancers in addition to Crohn’s. - Classic Triad: diarrhea, weight loss, feculent emesis - Only present in 30% of cases - Presence of feculent emesis helps to distinguish gastrocolic from more distal entero-enteric fistulas Epidemiology - Rare complication noted in only 0.6% of CD pt - Youngest reported case in a 13 yo pt who had CD for 3 yrs, however most pts range 25-60 with disease duration >10 yrs - M=F - Predisposing factors: Ileal disease and prior ileocolic anastomoses Pathogenesis - Most form from mid- to distal transverse colon to the greater curvature of the stomach - Initiate from active area of colitis - Multiple cases with evidence of proximal disease on resection implying gastric to colic or bidirectional formation Greenstein, Diseases of Colon and Rectum. 1989. -
Crohn's Disease of the Anal Region
Gut: first published as 10.1136/gut.6.6.515 on 1 December 1965. Downloaded from Gut, 1965, 6, 515 Crohn's disease of the anal region B. K. GRAY, H. E. LOCKHART-MUMMERY, AND B. C. MORSON From the Research Department, St. Mark's Hospital, London EDITORIAL SYNOPSIS This paper records for the first time the clinico-pathological picture of Crohn's disease affecting the anal canal. It has long been recognized that anal lesions may precede intestinal Crohn's disease, often by some years, but the specific characteristics of the lesion have not hitherto been described. The differential diagnosis is discussed in detail. In a previous report from this hospital (Morson and types of anal lesion when the patients were first seen Lockhart-Mummery, 1959) the clinical features and were as follows: pathology of the anal lesions of Crohn's disease were described. In that paper reference was made to Anal fistula, single or multiple .............. 13 several patients with anal fissures or fistulae, biopsy Anal fissures ........... ......... 3 of which showed a sarcoid reaction, but in whom Anal fissure and fistula .................... 3 there was no clinical or radiological evidence of Total 19 intra-abdominal Crohn's disease. The opinion was expressed that some of these patients might later The types of fistula included both low level and prove to have intestinal pathology. This present complex high level varieties. The majority had the contribution is a follow-up of these cases as well as clinical features described previously (Morson and of others seen subsequently. Lockhart-Mummery, 1959; Lockhart-Mummery Involvement of the anus in Crohn's disease has and Morson, 1964) which suggest Crohn's disease, http://gut.bmj.com/ been seen at this hospital in three different ways: that is, the lesions had an indolent appearance with 1 Patients who presented with symptoms of irregular undermined edges and absence of indura- intestinal Crohn's disease who, at the same time, ation. -
Original Article Efficacy of Radical Incision and Drainage for Perianal Abscesses and Related Serum Activin a Levels
Int J Clin Exp Med 2020;13(7):5100-5107 www.ijcem.com /ISSN:1940-5901/IJCEM0111399 Original Article Efficacy of radical incision and drainage for perianal abscesses and related serum activin A levels Hengqing Gao1, Runping Liu1, Zhengchun Yang3, Xiaoqiang Wang1, Wei Wang1, Furao Gong1, Jing Hu2 Departments of 1Anorectal, 2Science and Education, Zigong Hospital of Traditional Chinese Medicine, Zigong, Sichuan Province, China; 3Sichuan Administration of Traditional Chinese Medicine, Chengdu, Sichuan Province, China Received March 25, 2020; Accepted April 24, 2020; Epub July 15, 2020; Published July 30, 2020 Abstract: Objective: To explore the efficacy of radical incision and drainage for patients with perianal abscess and its effect on serum activin A (ACTA) levels. Methods: A total of 128 patients with perianal abscesses were randomly divided into group A (radical incision and drainage, n = 64) and group B (simple incision and drainage, n = 64). Results: Visual analogue scale (VAS) score, gas, postoperative persistent infection and wound healing time in group A were significantly lower than those in group B (all P<0.001). Compared with group B, group A had significantly higher effective treatment rates, but lower serum ACTA levels 3 days after operation and lower recurrence rate of perianal abscess and anal fistula (P<0.001). Conclusion: The application of radical incision and drainage in patients with perianal abscesses can effectively reduce postoperative pain, and also has the advantages of faster postopera- tive recovery, lower incidence of adverse events and reduced inflammatory response. Radical incision and drainage and serum ACTA levels 3 days after operation are key factors for the recurrence of perianal abscess and anal fistula in patients with perianal abscesses.