Dr. Roberts Bartholow: “Strange Child of Genius” of Neurology
Total Page:16
File Type:pdf, Size:1020Kb
Load more
Recommended publications
-
Roberts Bartholow: the Progenitor of Human Cortical Stimulation and His Contentious Experiment
NEUROSURGICAL FOCUS Neurosurg Focus 47 (3):E6, 2019 Roberts Bartholow: the progenitor of human cortical stimulation and his contentious experiment Devi P. Patra, MD, MCh, MRCSEd,1,5,6 Ryan A. Hess, BSE,1,5,6 Karl R. Abi-Aad, MD,1,5,6 Iryna M. Muzyka, MD,4 and Bernard R. Bendok, MD, MSCI1–3,5,6 Departments of 1Neurological Surgery, 2Otolaryngology, 3Radiology, and 4Neurology, 5Precision Neuro-therapeutics Innovation Lab, and 6Neurosurgery Simulation and Innovation Lab, Mayo Clinic, Phoenix, Arizona Roberts Bartholow, a physician, born and raised in Maryland, was a surgeon and Professor in Medicine who had previ- ously served the Union during the Civil War. His interest in scientific research drove him to perform the first experiment that tested the excitability of the human brain cortex. His historical experiment on one of his patients, Mary Rafferty, with a cancerous ulcer on the skull, was one of his great accomplishments. His inference from this experiment and proposed scientific theory of cortical excitation and localization in humans was one of the most critically acclaimed topics in the medical community, which attracted the highest commendation for the unique discovery as well as criticism for possible ethical violations. Despite that criticism, his theory and methods of cortical localization are the cornerstone of modern brain mapping and have, in turn, led to countless medical innovations. https://thejns.org/doi/abs/10.3171/2019.6.FOCUS19349 KEYWORDS Roberts Bartholow; human cortical mapping; brain localization; Mary Rafferty; cortical excitability; history of brain mapping Perhaps a corpse would be reanimated; galvanism had given tion of “living” animals was attempted by Luigi Rolando tokens of such things: perhaps the component parts of a crea- in 1809 and by Hitzig and Fritsch in 1870.34,42 However, ture might be manufactured, brought together and endued with it was in the late 19th century when functional mapping vital warmth. -
Experiment at Bedside : Harvey Cushing’S Neurophysiological Research*
醫史學 제18권 제2호(통권 제35호) 2009년 12월 Korean J Med Hist 18ː205-222 Dec. 2009 醫史學 제18권 제2호(통권 제35호) 2009년 12월 Korean J Med Hist 18ː89106 Dec. 2009 ISSN 1225-505X ⒸⒸ大韓醫史學會大韓醫史學會 ISSN 1225-505X Experiment at Bedside : Harvey Cushing’s Neurophysiological Research* Ock-Joo KIM** Table of content 1. Cushing and surgical experimentalism 2. Innovative experimental operation on the pituitary 3. Experiment inseparable from treatment: trigeminal nerve experiment 4. Experiment on the operating table – localization of the sensory cortex 5. Identity, ethos, and human experimentation Often regarded as the founder of neurosurgery in stood at the center of the twentieth-century America, Harvey Cushing developed neurosurgery transformation of American medicine. Born in as a specialty during the early twentieth century.1) Cleveland, Ohio in 1869, Cushing received his A product of the reform of medical education medical education at the Harvard Medical School, during the late nineteenth century in America, he from 1891 to 1896.2) He then began a residency at * This work was supported by the Korea Research Foundation Grant funded by the Korean Government (KRF-2009-371-E00001). ** Department of History of Medicine and Medical Humanities, Seoul National University College of Medicine 1) Cushing has been commemorated as the pioneer of neurosurgery in America. For the life of Harvey Cushing, see E. R. Laws, Jr. Neurosurgery's Man of the Century: Harvey Cushing – the man and his legacy. Neurosurgery 1999;45:977-82; S. I. Savitz. The pivotal role of Harvey Cushing in the birth of modern neurosurgery. the Journal of the American Medical Association (JAMA) 1997;278:1119; R. -
Dr. Rajneesh Kumar Sharma MD (Hom)
2013 A TREATISE ON NEOCORTEX AND ITS FUNCTIONS IN CONTEXT OF PRINCIPLES OF Dr. Rajneesh Kumar Sharma MD (Hom) A Treatise on Neocortex and its Functions in context of Homoeopathy A TREATISE ON NEOCORTEX AND ITS FUNCTIONS IN CONTEXT OF PRINCIPLES OF HOMOEOPATHY 1 Dr. Rajneesh Kumar Sharma MD (Hom) A Treatise on Neocortex and its Functions in context of Homoeopathy 2 Dr. Rajneesh Kumar Sharma MD (Hom) A Treatise on Neocortex and its Functions in context of Homoeopathy A TREATISE ON NEOCORTEX AND ITS FUNCTIONS IN CONTEXT OF PRINCIPLES OF HOMOEOPATHY By Dr. Rajneesh Kumar Sharma MD (Hom) 3 Dr. Rajneesh Kumar Sharma MD (Hom) A Treatise on Neocortex and its Functions in context of Homoeopathy A TREATISE ON NEOCORTEX AND ITS FUNCTIONS IN CONTEXT OF PRINCIPLES OF HOMOEOPATHY By Dr. Rajneesh Kumar Sharma MD (Hom) Homoeo Cure & Research Institute NH- 74, Moradabad Road Kashipur (Uttarakhand) Pin- 244713 INDIA First Edition 2013 4 Dr. Rajneesh Kumar Sharma MD (Hom) A Treatise on Neocortex and its Functions in context of Homoeopathy Dedication Dedicated To my parents- who dreamt up me! To my family- that sustained me! To my collegues and friends- who shored up me! & To Homoeopathy- which coddled me! cosseted & dissolved me into it! 5 Dr. Rajneesh Kumar Sharma MD (Hom) A Treatise on Neocortex and its Functions in context of Homoeopathy Dr. Christian Friedrich Samuel Gottfried Hahnemann, German physician, Founder of Homeopathy Born: April 10th, 1755, 11.55 PM Meissen Died: July 02nd, 1843, 5.00 AM Paris 6 Dr. Rajneesh Kumar Sharma MD (Hom) A Treatise on Neocortex and its Functions in context of Homoeopathy Acknowledgement I am extremely grateful to Padm Shree Dr. -
Thomas, R. K., & Young, C. D. (1993). a Note on the History of Electrical
The Journal of General Psychology, 120(1), 73-81 Erratum: In the Abstract (line 6) the phrase "especially of footnote 16 in Hltzig's (1870) report'' is incorrect. The phrase should be "especially of footnote 16 pertalning to Hltzig's (1870 report". A Note on the Early History of Electrical Stimulation of the Human Brain ROGER K. THOMAS CHERYL DONALDSON YOUNG Department of Psychology University of Georgia ABSTRACT. We address inconsistencies in two areas concerning who was first to electrically stimulate a human's brain. First, Boring (1950) and others attributed priority to Eduard Hitzig based on information mentioned somewhat incidentally in Fritsch and Hitzig's (1870) classic work using dogs. Others cited Fritsch and Hitzig but attributed priority to Roberts Bartholow (1874). Second, our examination of translations of Fritsch and Hitzig, especially of footnote 16 in Hitzig 's report ( 1870) of a human case, revealed errors, omissions, and inconsistencies. To aid our inquiry, we requested and received new translations of footnote 16 and of Hitzig's report. THIS NOTE ORIGINATED in our discoveries of sonie interesting inconsist encies in the literature associated with who was first to electrically stimulate a human's brain. These inconsistencies divide approximately into two cate gories. The first category concerns Fritsch and Hitzig's (1870) article on electri cal stimulation of the dog's brain, a classic in neurophysiology. Based, most likely, on his own reading of this classic work, E. G. Boring ( 1950) wrote: This famous joint experiment originated in Hitzig's observation that the electri cal stimulation of the cortex of a man, [italics added] led to movement of the eyes. -
Engineering in Brain Research, from the Development of Instrumentation, to the Analysis of Recorded Signals, to the Modelling of Brain Function
E GINEERI GIN RAIN RES ARCH Processing Electroencephalograms and Chaos in Neural Networks A thesis presented for the degree of Doctor of Philosophy in Electrical and Electronic Engineering at the University of Canterbury, Christchurch, New Zealand. November 1992. Alison A. Dingle B. E. (Hans 1) ABSTRACT The structure and function of the brain, as it is presently understood, is outlined. The importance of technology in acquiring this knowledge is illustrated by tracing the history of brain research, and the contributions that engineering is currently making to brain research are discussed. The manifestation of epilepsy in recordings of the electrical activity of the brain - elec troencephalograms (EEGs) is outlined. A new PC-based system for the automated de tection of this epileptiform activity is presented. The system consists of three stages: data collection, feature extraction and event detection. The feature extraction stage detects candi date epileptiform transients on individual channels, while an expert system is used to detect focal and non-focal epileptiform events. Considerable use of spatial and temporal contextual information present in the EEG aids both in the detection of epileptiform events and in the rejection of artifacts and background activity as events. Classification of events as definite or probable overcomes, to some extent, the problem of maintaining satisfactory detection rates while eliminating false detections. Test results are presented whlch indicate that this system should be capable of performing reliably in routine clinical EEG screening. Neural networks are introduced and their application to real-world problems examined. In particular, the application of back-propagation neural networks to the detection of epilep tiform transients is discussed. -
Landmark Discoveries in Neurosciences
GENERAL ¨ ARTICLE Landmark Discoveries in Neurosciences Niranjan Kambi and Neeraj Jain The study of the basis of mental phenomena or the mind has always intrigued humans. Our current understanding of the functioning of the brain is the result of insightful research by many scientists, which has led to a detailed knowledge of brain structure and how this structure makes it possible for (left) Niranjan Kambi is a senior graduate student at the mind to emerge from it. National Brain Research Centre, Manesar, 1. Early Ideas About the Mind and Matter Haryana. He is interested in understanding how the As far as the recorded history goes, humans have wondered about brain enables organisms to the nature and basis of our own existence. Early thinkers seem to exhibit complex behaviour have realized that before they can answer the question ‘Who am such as sensoryperception, I?’, they had to understand the origin of the thought process itself. voluntary movement, and decision making. They had to understand what is mind, and if it is different from the body. Gautam Buddha, as early as 500 BC, proposed that mental (right) Neeraj Jain is a scientist at National Brain life is causally interconnected with matter. This view was radi- Research Centre, Manesar, cally different from that prevailing in the Vedic philosophy, Haryana. His primary which had existed for more than a thousand years. research work is on information processing in In Western philosophy, the history of ideas about the mind started the touch and the with the notion of duality; there are two fundamental kinds of movement systems of the brain, and how spinal cord substances: mental and material.