Toothpaste Abrasiveness Ranked by RDA (Relative Dentin Abrasion) Value
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Gel-Syn™ Product Information Caution
GEL-SYN™ PRODUCT INFORMATION CAUTION: Federal law restricts this device to sale by or on the order of a physician (or properly licensed practitioner). CONTENT Each 1 mL of Gel-Syn contains: Sodium Hyaluronate: 8.4 mg Sodium Chloride: 8.5 mg Sodium Phosphate, Dibasic: 0.16 mg Sodium Phosphate, Monobasic: 0.045 mg Water for Injection: q.s. to 1.0 mL DESCRIPTION Gel-Syn is a sterile, buffered solution of highly purified sodium hyaluronate with a molecular weight of approximately 1100 kDa, obtained through fermentation of Streptococci of Lancefield groups A and C and chemically unmodified. INDICATION Gel-Syn is indicated for the treatment of pain in osteoarthritis (OA) of the knee in patients who have failed to respond adequately to conservative non-pharmacologic therapy and simple analgesics (e.g., acetaminophen). CONTRAINDICATIONS • Do not administer to patients with known hypersensitivity (allergy) to sodium hyaluronate preparations. • Do not inject Gel-Syn into the knees of patients having knee joint infections or skin diseases or infections in the area of the injection site. WARNINGS • Do not concomitantly use disinfectants containing quaternary ammonium salts for skin preparation because sodium hyaluronate can precipitate in their presence. • Inject into the synovial space only. Do not inject by intravascular route. • Do not inject outside the synovial space or into the synovial tissue or capsule. An extra- articular injection of the product can cause local adverse events. PRECAUTIONS General • The safety and effectiveness of Gel-Syn in locations other than the knee, and for conditions other than osteoarthritis, have not been established. • Strict aseptic administration technique must be followed. -
Physical-Chemical Characteristics of Whitening Toothpaste and Evaluation of Its Effects on Enamel Roughness
Dental materials Physical-chemical characteristics of whitening toothpaste and evaluation of its effects on enamel roughness Sérgio Paulo Hilgenberg(a) Abstract: This in vitro study evaluated the physical-chemical characteris- (a) Shelon Cristina Souza Pinto tics of whitening toothpastes and their effect on bovine enamel after ap- Paulo Vitor Farago(b) Fábio André Santos(a) plication of a bleaching agent (16% carbamide peroxide). Physical-chem- Denise Stadler Wambier(a) ical analysis was made considering mass loss by desiccation, ash content and pH of the toothpastes. Thirty bovine dental enamel fragments were prepared for roughness measurements. The samples were subjected to (a) Department of Dentistry, School of Dentistry, Ponta Grossa State University, bleaching treatments and simulated brushing: G1. Sorriso Dentes Brancos Ponta Grossa, PR, Brazil. (Conventional toothpaste), G2. Close-UP Whitening (Whitening tooth- (b) Department of Pharmacy, School of paste), and G3. Sensodyne Branqueador (Whitening toothpaste). The av- Dentistry, Ponta Grossa State University, erage roughness (Ra) was evaluated prior to the bleaching treatment and Ponta Grossa, PR, Brazil. after brushing. The results revealed differences in the physical-chemical characteristics of the toothpastes (p < 0.0001). The final Ra had higher values (p < 0.05) following the procedures. The mean of the Ra did not show significant differences, considering toothpaste groups and bleach- ing treatment. Interaction (toothpaste and bleaching treatment) showed significant difference -
An Introduction to Fast Dissolving Oral Thin Film Drug Delivery Systems: a Review
Muthadi Radhika Reddy /J. Pharm. Sci. & Res. Vol. 12(7), 2020, 925-940 An Introduction to Fast Dissolving Oral Thin Film Drug Delivery Systems: A Review Muthadi Radhika Reddy1* 1School of pharmacy, Gurunanak Institute of Technical Campus, Hyderabad, Telangana, India and Department of Pharmacy, Gandhi Institute of Technology and Management University, Vizag, Andhra Pradesh, India INTRODUCTION 2. Useful in situations where rapid onset of action Fast dissolving drug delivery systems were first developed required such as in motion sickness, allergic attack, in the late 1970s as an alternative to conventional dosage coughing or asthma forms. These systems consist of solid dosage forms that 3. Has wide range of applications in pharmaceuticals, Rx disintegrate and dissolve quickly in the oral cavity without Prescriptions and OTC medications for treating pain, the need of water [1]. Fast dissolving drug delivery cough/cold, gastro-esophageal reflux disease,erectile systems include orally disintegrating tablets (ODTs) and dysfunction, sleep disorders, dietary supplements, etc oral thin films (OTFs). The Centre for Drug Evaluation [4] and Research (CDER) defines ODTs as,“a solid dosage 4. No water is required for the administration and hence form containing medicinal substances which disintegrates suitable during travelling rapidly, usually within a matter of seconds, when placed 5. Some drugs are absorbed from the mouth, pharynx upon the tongue” [2]. USFDA defines OTFs as, “a thin, and esophagus as the saliva passes down into the flexible, non-friable polymeric film strip containing one or stomach, enhancing bioavailability of drugs more dispersed active pharmaceutical ingredients which is 6. May offer improved bioavailability for poorly water intended to be placed on the tongue for rapid soluble drugs by offering large surface area as it disintegration or dissolution in the saliva prior to disintegrates and dissolves rapidly swallowing for delivery into the gastrointestinal tract” [3]. -
Acrylamide Polymerization — a Practical Approach
electrophoresis tech note 1156 Acrylamide Polymerization — A Practical Approach Paul Menter, Bio-Rad Laboratories, 2000 Alfred Nobel Drive, Polyacrylamide Gel Polymerization Hercules, CA 94547 USA AcrylamideBis Polyacrylamide Introduction The unparalleled resolution and flexibility possible with CH2 CH + CH2 CH CH2 CH CH2 CH CH2 CH polyacrylamide gel electrophoresis (PAGE) has led to its CO CO CO CO CO widespread use for the separation of proteins and nucleic NH2 NH NH2 NH2 NH acids. Gel porosity can be varied over a wide range to meet CH2 CH2 specific separation requirements. Electrophoresis gels and NH NH NH NH buffers can be chosen to provide separation on the basis of CO 2 2 CO CO C O charge, size, or a combination of charge and size. CH2 CH CH2 CH CH2 CH CH2 CH The key to mastering this powerful technique lies in the polymerization process itself. By understanding the important Purity of Gel-Forming Reagents parameters, and following a few simple guidelines, the novice Acrylamide can become proficient and the experienced user can optimize Gel-forming reagents include the monomers, acrylamide and bis, separations even further. as well as the initiators, usually ammonium persulfate and TEMED or, occasionally, riboflavin and TEMED. On a molar This bulletin takes a practical approach to the preparation of basis, acrylamide is by far the most abundant component in the polyacrylamide gels. Its purpose is to provide the information monomer solution. As a result, acrylamide may be the primary required to achieve reproducible, controllable polymerization. source of interfering contaminants (Dirksen and Chrambach For those users interested only in the “bare essentials,” the 1972). -
Sucralfate Enemas
Sucralfate Enemas Sucralfate enemas are used to treat inflammation of the rectum (the lower part of the large intestine leading to the anus); most commonly this is for radiation proctitis; bowel inflammation following radiotherapy. This treatment can help treat bleeding due to the inflammation, and can be continued for up to 24 weeks; you can stop when the bleeding stops. This fact sheet explains how you can administer the enema yourself, using a syringe and catheter. The hospital or community pharmacy can provide the Sucralfate enema, and you will need to ask your GP or practise nurse to supply the equipment you will need. Your practise nurse can help you practice preparing the enema, and could help you with administering it at home, if you find this difficult. 1. Using the syringe provided, draw up 10mls of the Sucralfate Suspension (2g) and then draw up 10mls of warm water and mix. Ensure that any excess air is expelled from the syringe. 2. Attach the catheter provided to the syringe tip and lubricate the end of the catheter with lubricating gel provided. 3. Lie on your left side with both knees bent. This position will help the flow of liquid in to the rectum and aid enema retention. 4. Position a towel underneath yourself to catch any leakage of fluid once the enema has been administered. 5. With a steady pressure, gently insert the catheter to a depth of approximately 10cm into the rectum. 6. Press down on the barrel of the syringe slowly, using a steady and even pressure, until the entire contents of the syringe have been administered. -
Innovation Is P&G's Life Blood
Innovation is P&G Innovations P&G’s Life Blood It is the company’s core growth strategy and growth engine. It is also one of the company’s five core strengths, outlined for focus and investment. Innovation translates consumer desires into new products. P&G’s aim is to set the pace for innovation and the benchmark for innovation success in the industry. In 2008, P&G had five of the top 10 new product launches in the US, and 10 of the top 25, according to IRI Pacesetters, a report released by Information Resources, Inc., capturing the most successful new CPG products, as measured by sales, over the past year. Over the past 14 years, P&G has had 114 top 25 Pacesetters—more than our six largest competitors combined. PRODUCT INNOVATION FIRSTS 1879 IVORY First white soap equal in quality to imported castiles 1901 GILLETTE RAZOR First disposable razor, with a double-edge blade, offers alternative to the straight edge; Gillette joins P&G in 2005 1911 CRISCO First all-vegetable shortening 1933 DREFT First synthetic household detergent 1934 DRENE First detergent shampoo 1946 TIDE First heavy-duty The “washday miracle” is introduced laundry detergent with a new, superior cleaning formula. Tide makes laundry easier and less time-consuming. Its popularity with consumers makes Tide the country’s leading laundry product by 1949. 1955 CREST First toothpaste proven A breakthrough-product, using effective in the prevention fluoride to protect against tooth of tooth decay; and the first decay, the second most prevalent to be recognized effective disease at the time. -
Colgate Blue Minty Gel Toothpaste This Industrial Safety Data Sheet Is Not Intended for Consumers and Does Not Address Consumer Use of the Product
APJ Colgate Blue Minty Gel Toothpaste This industrial Safety Data Sheet is not intended for consumers and does not address consumer use of the product. For information regarding consumer applications of this product, refer to the product label. Version Revision Date: SDS Number: Date of last issue: - 1.0 23.11.2016 660000003786 Date of first issue: 23.11.2016 SECTION 1. PRODUCT AND COMPANY IDENTIFICATION Product name : Colgate Blue Minty Gel Toothpaste Product code : 200000015708 : B05408280003 Manufacturer or supplier's details Company : Colgate-Palmolive Co Colgate-Palmolive Central America Region Address : Colgate-Palmolive Pty Ltd., 345 George St, Sydney, New South Wales, Australia 2000. Telephone : Consumer affairs: - AU 1800 802 307 (Mon – Fri 9 - 5) Emergency telephone number : CHEMTREC Australia +(61)-290372994 Global-CHEMTREC- +1 703-741-5970 Telefax : +50250224239500 나.Recommended use of the chemical and restrictions on use Recommended use : A formulated dentifrice. SECTION 2. HAZARDS IDENTIFICATION GHS Classification Serious eye damage/eye irri- : Category 2A tation GHS label elements Hazard pictograms : Signal word : Warning Hazard statements : H319 Causes serious eye irritation. 1 / 11 APJ Colgate Blue Minty Gel Toothpaste This industrial Safety Data Sheet is not intended for consumers and does not address consumer use of the product. For information regarding consumer applications of this product, refer to the product label. Version Revision Date: SDS Number: Date of last issue: - 1.0 23.11.2016 660000003786 Date of first issue: 23.11.2016 Precautionary statements : Prevention: P264 Wash skin thoroughly after handling. P280 Wear eye protection/ face protection. Response: P305 + P351 + P338 IF IN EYES: Rinse cautiously with water for several minutes. -
Injection of Stabilized Hyaluronic Acid-Based Gel of Non-Animal Origin for the Correction of Nasolabial Folds: Comparison with and Without Lidocaine
Injection of Stabilized Hyaluronic Acid-Based Gel of Non-Animal Origin for the Correction of Nasolabial Folds: Comparison with and without Lidocaine à y à z PER HEDE´ N,PHD, DAN FAGRELL, MD, JAN JERNBECK, MD, RICHARD RYLANDER, MD, à z z ULF SAMUELSON,PHD, GABRIELLA SELLMAN, MD, AND BIRGIT STARK,PHD BACKGROUND The use of injectable hyaluronic acid–based gel of non-animal origin, manufactured using the patented NASHA technology, is well established in aesthetic facial procedures. OBJECTIVE To compare injection pain, dermal filler efficacy, and safety of NASHA-based gel with or without 0.3% lidocaine hydrochloride when administered to the nasolabial fold (NLF). METHODS Forty-three subjects seeking correction of NLFs, with moderate or severe wrinkle severity, were recruited for this split-face, double-blind, comparative study. NASHA-based gel, with or without lidocaine hydrochloride, was injected into the deep layer of the dermis and/or subcutis, of the NLF. Pain, efficacy, and safety assessments included a treatment preference question, a 100-mm visual analogue scale for pain, the Wrinkle Severity Rating Scale, and adverse event reporting. RESULTS Ninety percent of subjects (lower 95% confidence limit=76%) rated injection of NASHA- based gel with lidocaine as less painful than NASHA-based gel alone. Subjects and physicians reported no significant differences in dermal filler efficacy between the two treatments during the 12-month follow-up period. The safety profile was similar for both products. CONCLUSION NASHA-based gel with lidocaine provides a more comfortable treatment experience than NASHA-based gel alone, with equivalent efficacy and safety observed after 12 months of follow-up. -
CLOSE up Red Gel Toothpaste
CLOSE UPTM Red Gel Toothpaste Safety Data Sheet According To Federal Register / Vol. 77, No. 58 / Monday, March 26, 2012 / Rules And Regulations Revision Date: 04/21/2015 Date of issue: 04/21/2015 Supersedes Date: 02/25/2004 Version: 1.0 SECTION 1: IDENTIFICATION Product Identifier Product Form: Mixture Product Name: CLOSE UPTM Red Gel Toothpaste Intended Use of the Product Oral Care. Name, Address, and Telephone of the Responsible Party Company Church & Dwight 500 Charles Ewing Blvd Ewing Township, NJ 08628 T 1-800-524-1328 www.churchdwight.com Emergency Telephone Number Emergency Number : For Medical Emergency: 1-888-234-1828, For Chemical Emergency: 1-800-424-9300 (CHEMTREC) SECTION 2: HAZARDS IDENTIFICATION This product is labeled in accordance with regulations administered by the Consumer Product Safety Commission (CPSC). The use pattern and exposure in the workplace are generally not consistent with those experienced by consumers. The requirements of the Occupational Safety and Health Administration applicable to this SDS differ from the labeling requirements of the CPSC and, as a result, this SDS may contain additional health hazard information not pertinent to consumer use and not found on the product label. Classification of the Substance or Mixture Classification (GHS-US) Skin Sens. 1 H317 Full text of H-phrases: see section 16 Label Elements GHS-US Labeling Hazard Pictograms (GHS-US) : GHS07 Signal Word (GHS-US) : Warning Hazard Statements (GHS-US) : H317 - May cause an allergic skin reaction. Precautionary Statements (GHS-US) : P261 - Avoid breathing vapors, mist, or spray. P272 - Contaminated work clothing must not be allowed out of the workplace. -
Barium Enema? Your Child’S Doctor Will Tell You If There Are Special Test to Get More Information
9. After your child has had a bowel movement, the during the test. Bring along a book for your child to Your Child’s Care technologist will take a few more X-rays of the read during waiting periods. The Le Bonheur radiology staff wants to care large intestine without the barium. For adolescents, privacy may be their biggest for your child’s physical and emotional needs. The 10. A doctor trained in reading X-rays will study concern. Explain the test to your teen, and encourage information in this brochure will answer questions you the pictures and send the results to your him/her to ask us questions. or your child may have about the scheduled barium child’s doctor. enema, and help prepare your child for the test. Does my child have to do anything Your child’s doctor can also answer any questions How do I tell my child about the different before the test? you may have, or you can call the Le Bonheur radiology department where your child will have the barium enema? Your child’s doctor will tell you if there are special test to get more information. Please talk to your child before you come to Le things to do before your child has the test. Please call Bonheur. It will make the procedure easier for you Radiology at 901-287-7041 if you need further What is a barium enema? and your child. Assure your child that any discomfort instructions. will only last a few minutes, and that the test will A barium enema helps the doctor see how the If your child is scheduled for an air contrast barium, not hurt. -
Formulation of Topical Bioadhesive Gel of Aceclofenac Using 3-Level Factorial Design
Archive of SID Iranian Journal of Pharmaceutical Research (2011), 10 (3): 435-445 Copyright © 2011 by School of Pharmacy Received: September 2009 Shaheed Beheshti University of Medical Sciences and Health Services Accepted: February 2010 Original Article Formulation of Topical Bioadhesive Gel of Aceclofenac Using 3-Level Factorial Design Sanjay Singh*, Rabinarayan Parhi and Anuj Garg Department of Pharmaceutics, Institute of Technology, Banaras Hindu University, Varanasi, 221005, India. Abstract The objective of this work was to develop bioadhesive topical gel of Aceclofenac with the help of response-surface approach. Experiments were performed according to a 3-level factorial design to evaluate the effects of two independent variables [amount of Poloxamer 407 (PL-407 = X1) and hydroxypropylmethyl cellulose K100 M (HPMC = X2)] on the bioadhesive character of gel, rheological property of gel (consistency index), and in-vitro drug release. The best model was selected to fit the data. Mathematical equation was generated by Design Expert® software for the model which assists in determining the effect of independent variables. Response surface plots were also generated by the software for analyzing effect of the independent variables on the response. Quadratic model was found to be the best for all the responses. Both independent variable (X1 and X2) were found to have synergistic effect on bioadhesion (Y1) but the effect of HPMC was more pronounced than PL-407. Consistency index was enhanced by increasing the level of both independent variables. An antagonistic effect of both independent variables was found on cumulative percentage release of drug in 2 (Y3) and 8 h (Y4). Both independent variables approximately equally contributed the antagonistic effect on Y3 whereas antagonistic effect of HPMC was more pronounced than PL-407. -
Vicks® Launches New Nature Fusion™ Line
VICKS® LAUNCHES NEW NATURE FUSION™ LINE Nature Fusion cough, cold and flu products offer the powerful symptom relief, plus real honey for taste Cincinnati, OH, August 11, 2011 – Procter & Gamble’s (NYSE: PG) Vicks brand announced today that it is launching Nature Fusion, a new line of over-the-counter cold, cough and flu relief products that combine powerful symptom relief with real honey for flavor. What inspired Vicks Nature Fusion? Research shows that consumers increasingly desire more natural and less artificial ingredients in their over-the- counter medications, so Vicks is answering the call with Nature Fusion, which joins the powerful science of symptom relief with the best of nature. Beginning with the original Vicks products launched in 1894 which contained Eucalyptus oils from Australia and menthol from Japan, Vicks has a long history of using ingredients inspired by nature. Now, Vicks is continuing this tradition by blending real honey for flavor in new Vicks Nature Fusion. “For more than 120 years, Vicks has helped people feel better by providing proven treatments to deliver effective relief from cold, cough and flu symptoms,” says Andy Cipra, Vicks Brand Manager. “Today, with the launch of Nature Fusion, Vicks is proud to offer the same powerful medicine now flavored with real honey.” Honey has often been favored as a flavor, but lately it has been getting even more buzz as consumers increasingly seek natural ingredients in the products they use. The addition of honey provides aesthetic properties such as flavor, sweetness and thickness. Nature Fusion is also free from alcohol and gluten.