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Dec. 10, 2004 Volume 29 No. 17 Washington University in StlDuis Scientists grow norovirus in lab

In a study Is common cause published in November in of food poisoning the online jour- nal Public BY MICHAEL C. PURDY Library of Science-Biology, School of Medicine scientists scientists who have become the first to suc- developed the cessfully grow a norovirus in Virgin new technique the lab. reported it may In humans, noroviruses are a already have led them to a good highly contagious source of diar- target for vaccine development. rhea, vomiting and other stomach "By looking at the mouse virus ailments that made headlines two we'd grown in the lab, we were years ago after a series of repeated able to identify a part of the cap- outbreaks on cruise ships. These sid, the virus' protein shell, that is viruses are a major cause of hu- essential to its ability to cause dis- man disease worldwide. ease," said senior author Herbert Researchers showed that the W. "Skip" Virgin, M.D., Ph.D., mouse norovirus MNV-1 could be professor of pathology and im- grown inside cells from mice with munology and of molecular mi- Campaign Celebration Chancellor Mark S. Wrighton receives a standing ovation as he pre- defective immune systems. Their crobiology. "If this part of the pares to address the hundreds who gathered Dec. 3 at the Renaissance Grand Hotel in downtown findings make it much easier to capsid has an equivalent in hu- St. Louis for a gala celebration marking the success of the Campaign for Washington University. learn about the mouse virus and man noroviruses, altering or dis- Attendees were treated to an evening of food, presentations and music and dancing with the Steve may help other researchers seeking abling it may give us a way to pro- Schankman Orchestra. The campaign, the fund-raising initiative launched to secure the resources to duplicate the accomplishment duce forms of the viruses that are needed to realize the University's potential for the good of generations to come, ended June 30 with with human forms of the virus. See Lab, Page 6 $1.55 billion in gifts and commitments and a record 165 new endowed professorships. Mental-health MetroLink project moves center earns advanced toward 2006 completion BY ANDY CLENDENNEN pedestrian bridge. Concrete work will also continue at the tunnel designation Just like the little engine — west of DeBaliviere Avenue. or mass transit train — that At the two other new stations BY JESSICA MARTIN could, the MetroLink cross-coun- adjacent to University campuses ty expansion just keeps on chug- — the University City/Big Bend The Center for Mental Health ging along. Boulevard and Forsyth stations, Services Research (CMHSR) in And December should bring concrete work will continue, and the George Warren Brown School more of the same as Metro chugs shoring and excavation work will of Social Work has received fund- toward an anticipated project- continue for a tunnel between Big ing from the National Institute of completion date in mid-2006. Bend and Kingsland Avenue. Mental Health (NIMH) to be- Mass excavation efforts will Concrete work will continue in come the nation's first Advanced continue at the Skinker Avenue the tunnel between Big Bend and Center for Interventions and Ser- station at the intersection of Skin- Pershing Avenue. vices Research at a school of ker and Forest Park Parkway. As with any major construc- social work. Concrete work is scheduled to tion endeavors, minor side irrita- CMHSR will celebrate its new begin at the Skinker tunnel. tions will pop up once in a while. designation and expanded re- Construction of the station Again, the same holds true for the search agenda during an opening As viewed looking north, at Forest Park Parkway just east of Big entrance, at the southwest corner coming months. and reception from 1-2:30 p.m. Bend Boulevard, construction crews work on a new MetroLink sta- of that intersection, will continue, The pedestrian crossing of Jan. 11 in the Brown Hall Lounge. tion. Metro is anticipating that the cross-county expansion project will be finished in mid-2006. as well as substructure work for a See MetroLink, Page 2 Visitors can hear about the cen- ter's current and future research from CMHSR leaders. "We are proud and excited to Mother Nature's nuclear reactor Olin Cup entrepreneurship contest have received support for this next, more ambitious phase of described by WUSTL researchers winners named; Luminomics is 1st our research," said Enola K. Proc- tor, Ph.D., center director and the BY TONY FITZPATRICK Analyzing a fragment of Ga- In this year's Olin Cup entre- An honorable mention was Frank J. Bruno Professor of Social bon-site rock that's less than one- Ipreneurshipt competition, the given to Core Devices, maker of Work Research. To operate a nuclear power eighth of an inch, Alexander Me- Olin School of Business has a portable anesthesia machine. "This advanced center pro- plant like Three Mile Island, shik, Ph.D., senior research scien- awarded a total of $70,000 in "We've created an open, vides critical core support to our hundreds of highly trained em- tist in the Department of Physics seed investment capital to two inclusive environment for team faculty as they test new ways to ployees must work in concert to in Arts & Sciences, has calculated startup businesses. formation," said Kenneth A. meet the mental health needs of generate power from safe fission, that the precise isotopic structure The awards were announced Harrington, managing director the most vulnerable members of all the while containing danger- of xenon in the sample reveals Dec. 2 at a reception in Simon of the Skandalaris Center for our society — those served by ous nuclear wastes. an operation that worked like a Hall. Entrepreneurial Studies, which publicly funded social service On the other hand, it's been geyser. The reactor, active 2 bil- The Olin Cup for first place, sponsors the competition. "A agencies. Finding out how to im- known for 30 years that Mother lion years ago, worked on a 30- along with $50,000 in seed business startup idea can be prove the quality of their mental Nature once did nuclear chain minute reaction cycle, accompa- money, went to Luminomics, a submitted from anywhere in See Center, Page 6 reactions by her lonesome. nied by a 2.5-hour dormant peri- biotechnology company that the University or community, Now, University researchers od, or cool-down. develops regenerative drug ther- and funding will be made avail- Happy holidays! have analyzed the isotopic struc- In a recent issue of Physical apies for degenerative diseases. able to teams having only one ture of noble gases produced in Review Letters, Meshik and his An award of $20,000 went to Olin student or recent alumnus The Record will not be pub- fission in a sample from the only University collaborators wrote: The Blessing Basket, a not-for- on the team. "But we are also actively lished again until Jan. 21. We known natural nuclear chain re- "This similarity (to a geyser) profit company that imports searching for sponsors and cor- hope you and your family have action site in the world in Gabon, suggests that a half an hour after baskets made by weavers in a wonderful holiday season. West Africa, and have found how the onset of the chain reaction, undeveloped countries. See Olin, Page 6 she does the trick. See Reactor, Page 6 WASHINGTON UNIVERSITY MEDICAL LIBRARY

3 2201 20337 2020 2 RECORD WASHINGTON UNIVERSITY IN ST. LOUIS Law dean advisory committee named BY ANDY CLENDENNEN dean of admissions and financial aid in the School of Law; Michael Chancellor Mark S. Wrighton R. Cannon, J.D., executive vice has appointed an advisory chancellor and general counsel; committee to assist him in Glenn L. Dalton, president of the search for the next dean of the the RKD Group; Rebecca S. Dres- School of Law. ser, J.D, the Daniel Noyes Kirby Joel D. Seligman, J.D., dean of Professor of Law; Jean C. Hamil- the School of Law and the Ethan ton, chief judge, U.S. District Court, A.H. Shepley University Professor, Eastern District of Missouri, and a announced recendy that he would member of the law school's nation- be leaving Washington University al council; Edward F. Lawlor, Ph.D., to become president of the Uni- dean of the George Warren Brown versity of Rochester. He is sched- School of Social Work; Stephen H. uled to step down here June 30. Legomsky, J.D, D.Phil., the Charles The Advisory Committee on F. Nagel Professor of International the Appointment of the Dean of and Comparative Law; the School of Law is charged with Ned O. Lemkemeier, J.D., mem- identifying 3-5 individuals with ber of the Board of Trustees, part- the intellectual, administrative, ner with Bryan Cave LLP, and personal and leadership qualities chair of the law school's national sought for the new dean, said council; Sasha E. Polonsky, student Wrighton, who hopes to complete in the School of Law; Nancy C. the appointment process by July 1. Staudt, J.D., professor of law; and Wrighton has named Daniel L. William H. Webster, member of Thomas distinguished professorship Edward S. Macias, Ph.D. (center), executive vice Keating, J.D., the Tyrell Williams the Board of Trustees and the law chancellor and dean of Arts & Sciences, was installed as the inaugural Barbara and David Thomas Distinguished Professor in Arts & Sciences in a ceremony Dec. 1 in the Arts & Sciences Professor of Law and dean for school's national council and sen- Laboratory Science Building. Chatting with Macias and his wife, Tedi, at the event Is John F. academic affairs, to chair the ior partner with Milbank, Tweed, McDonnell, retired chairman of the board of McDonnell Douglas Corp. and vice chairman of the committee. Hadley 8c McCloy LLP. University's Board of Trustees. In nearly 35 years at the University, Macias has served in numer- Other committee members The University has hired a con- ous roles, including University provost, chair of the Department of Chemistry in Arts & Sciences are: Jane Harris Aiken, J.D., the sultant to assist in the search and director of the Summer School. William M. Van Cleve Professor process; he is Jerry H. Baker of of Law; Janet L. Bolin, associate Baker-Parker Inc. in Adanta. Detjen named University trustee Martin Luther King's legacy David W. Detjen, J.D., a partner Professor of Biochemistry at undergraduate life, audit, medical honored via campus events in the New York office of Al- Technion-Israel Institute of finance, university finance, and ston & Bird LLP and co-chair of Technology, has been a visiting the Alumni Board of Governors. BY NEIL SCHOENHERR open to the public. For more the law firm's New York interna- professor of pediatrics in the information, call 935-5970. tional group, was named a mem- WUSTL School of Medicine About David W. Detjen £ i T%e the Change" is the ber of the University's Board of since 1987. Detjen, in addition to his role Dtheme of the University's Other MLK events Trustees at its Dec. 3 meeting. Wrighton reported that appli- with Alston & Bird, is executive annual celebration honoring Among other campus events is The announcement was made cations for the fall 2005 freshman editor of the International Law Martin Luther King Jr. at 7 p.m. the Black Law Students As- by Chancellor Mark S. Wrighton. class are strong and currendy are Practicum, a publication of the Jan. 17 in Graham Chapel. sociation's annual Martin Lu- At the meeting, trustees heard ahead of last year, as are applica- New York State Bar Association, Chancellor Mark S. ther King Jr. commemorative a presentation on career planning tions for early decision students. and several books ranging from Wrighton will begin the pro- speaker event. and placement by James E. Mc- Campus visits by high-school sen- how to arrange joint ventures gram with a welcome and Susan R. Jones, professor Leod, vice chancellor for students iors are up, a good sign of contin- with international partners to The remarks. The evening will of clinical law and supervising and dean of the College of Arts & uing interest in the University. Germans in Missouri, 1900-1918: include performances by Va- attorney of the Small Business Sciences, and John A. Berg, associ- Noted were the recent installa- Prohibition, Neutrality, and shon High School's drum line, Clinic at George Washington ate vice chancellor for undergrad- tions of four faculty members to Assimilation, published in 1985. the YMCA Boys Choir, the University, will present "Dr. uate admissions. Their report endowed professorships created Detjen is a member of the University's Vision Gospel Martin Luther King Jr.'s Legacy: dealt with the importance of ca- during the just-completed Cam- American Bar Association, the Choir and Black Anthology, An Economic Justice Impera- reer planning to students and paign for Washington University. New York State Bar Association, as well as testimonials from tive" at 11 a.m. Jan. 19 in An- their families, as well as strategies Altogether, 165 professorships the Bar Association of Metropoli- University students. heuser-Busch Hall. and programs being implemented were established during the cam- tan St. Louis, the Association of A reception in the Women's Jones is senior editor and to continue to provide strong paign. the Bar of the City of New York Building Formal Lounge will past editor in chief of the service to students during their Wrighton briefed the trus- and the German American Law follow the program. American Bar Association college years. tees on the appointment of Joel Association. The celebration is spon- Journal of Affordable Housing A report on the University's Seligman, J.D., dean of the School A 1970 graduate of Arts 8c sored by Black Anthology, the and Community Development self-study for the just-completed of Law and the Ethan A.H. Shep- Sciences at WUSTL, Detjen Black Student Council, Bon Law and author of A Legal North Central Association accred- ley University Professor, as presi- earned a degree from the Appetit, Campus Y, the Cath- Guide to Microenterprise Devel- itation visit was presented by dent of the University of Roches- University's School of Law in olic Student Union, Corner- opment. Gerhild Scholz Williams, Ph.D., ter; and on the search for a suc- 1973. He serves as a member of stone, the Disability Resource For more information, call associate vice chancellor for aca- cessor to Olin School of Business that school's national council, Center, the Office of Greek 935-4958. demic affairs, chair of the Depart- Dean Stuart I. Greenbaum, and in 1998 he received the Life, the Department of Psy- The Business Minority ment of Germanic Languages Ph.D., also the Bank of America school's distinguished alumni chology in Arts 8c Sciences, the Council will present a talk and Literatures, and the Barbara Professor of Managerial Lead- award. Office of Residential Life, the about King's contributions Schaps Thomas and David M. ership. While a law student, he was Office of Student Activities, toward equality in education Thomas Professor in the Human- Wrighton gave the trustees an editor in chief of the Washington the Office of Student Affairs, and the workplace and how his ities; and by James W. Davis, update on discussions regarding University Law Quarterly and was Student Union and the Wesley efforts have affected African- Ph.D., professor of political sci- the establishment of the Richard elected to the Order of the Coif. Fellowship. Americans in the business ence. Williams and Davis co- A. Gephardt Institute of Public He also studied law and history at This is the 18th year the world. The event will be at chaired the coordination of the Affairs, which will continue to the Eberhard-Karls-Universitat in University has supported a 3 p.m. Jan. 22 in Simon Hall. accreditation visit and the prepa- enhance the University's outreach Tubingen, Germany. King tribute. For more information, call ration of the detailed self-study. into the community through Alston & Bird has more than The celebration is free and 935-7301. In his report to the trustees, public service by students and 700 attorneys in five major mar- Wrighton noted several significant other members of the University kets, representing companies accomplishments during the past community. such as UPS, Verizon Wireless, few months, including the selec- The trustees received standing Bertelsmann AG, Wachovia tion of Aaron Ciechanover, M.D., committee reports on buildings Corp., BellSouth Corp., Delta Campus Watch D.Sc, to receive the 2004 Nobel and grounds/real estate, develop- Airlines Inc., AFLAC and The Prize in chemistry. Ciechan- ment, educational policy, Hilltop Prudential Insurance Co. of The following incidents were reported to University Police Dec. 2-8. Readers with informa- over, the Research Distinguished finance, research-graduate affairs, America. tion that could assist in investigating these incidents are urged to call 935-5555. This infor- mation is provided as a public service to promote safety awareness and is available on the University Police Web site at police.wustl.edu. wood Boulevard in Clayton. The and communications systems that parkway is scheduled to reopen in will be used for MetroLink - Dec. 3 Dec. 6 MetroLink 2005. Motorists are encouraged to tions. 1:45 a.m. — Residential Techno- 3:37 p.m. —A suspicious enve- Some alleys closed use Interstate 64 (Highway 40) or Residents in that area who logy Services reported a comput- lope postmarked from Algeria Olive Boulevard as alternate park their cars in their garages er-hacking incident in progress in was received by an occupant of during construction routes. and need their vehicles during Gregg House. A resident was con- the Angelica building at 700 - from Page 1 Even the alleys of some hous- those days need to have their cars tacted to establish the originator Rosedale Ave. The item was con- ing units are being impacted. out of the garages before 7 a.m. of the illicit computer action. It is veyed to the University Police From Dec. 7 and running for These dates and times may believed that this resident wasn't station to conduct a further Forest Park Parkway at Williams about two weeks, alleys behind change in the case of bad weather the perpetrator, but that the com- investigation, which is con- Avenue in University City is homes on the south side of Per- or unforeseen conditions. puter connection was being used tinuing. closed. All pedestrians should use shing, between Williams and the To receive a daily update on as a ghost server for the actual Additionally, University Police the pedestrian underpass at Wel- east end of the alley, are closed progress of the alley work, contact perpetrator. An investigation is responded to two reports each of lesley Avenue. from 7 a.m.-5:30 p.m. Jon Soucy with Metro Project continuing. property damage and auto acci- And Forest Park Parkway is This closure is necessary while Communications at jsoucy@ dent, and one report each of larce- closed between Union Boulevard Metro's contractor constructs an metrostlouis.org or 982-1400, ny, lost article, disturbance and in the city of St. Louis and Brent- underground room for signaling ex. 2709. suspicious person. record.wustl.edu WASHINGTON UNIVERSITY IN ST. LOUIS Dec. 10,2004 3 School of Medicine Update Heart responds to fasting by remodeling mitochondria

BY GWEN ERICSON more surprising because phos- pholipids comprise essential com- School of Medicine researchers ponents of all cellular membranes have identified a previously and have previously been thought unsuspected response by mouse to be preserved except in cases of heart muscle cells to fasting condi- extreme starvation. tions: the cells' power generators, The researchers' data also re- the mitochondria, appear to re- veals that after feeding resumes, model and consume extra internal the phospholipid levels in heart walls or membranes in an effort muscle cells rise back to normal to supply energy to the rest of levels, indicating that mitochon- the cell. dria readily rebuild their mem- Partially consumed are the spe- branes. cialized internal membranes mito- During this recovery period, chondria use to generate energy- another class of lipid, triglyceride, rich compounds for the cell, mak- a common source of energy for ing the mitochondrial strategy many types of cells, peaks high appear to create more problems above its normal level in heart than it might solve. Nevertheless, muscle cells. the response appears to help "The rise of triglyceride isn't maintain healthy heart function easily explained by nutritional throughout caloric restriction. conditions, because after feeding "It is likely that the changes in resumes, the heart shouldn't need the membranes make the mito- to increase its levels of fats," Gross chondria more energy efficient said. "It's as if the heart retains a and serve as an adaptation to nu- memory of deprivation and does- tritional deprivation in mam- n't want to get caught unprepared Check-mate it OUt Second-year medical students Eugenia Garvin (left) and Louise Yeung mals," said Richard Gross, M.D., again." examine a bronze work by Arts & Sciences anthropology doctoral student Blaine Maley. The piece Ph.D., senior author and professor The next step for the research was among 30 on display at an art show held Nov. 18 at the Bernard Becker Medical Library's of medicine and director of the team will be to study the changes King Center. Garvin and Yeung, along with fellow second-year student Yamini Virkud, coordinated Division of Bioorganic Chemistry in shape and structure of mito- the show, which also included poetry readings, photography, painting, drawing, quilting, pottery and Molecular Pharmacology in chondria and to relate these to and calligraphy by University students, faculty and staff. The well-attended show raised money for the Center of Creative Arts' Urban Arts Program In St.- Louis. the Department of Medicine. changes to lipid metabolism. The findings, scheduled to be The response by heart mito- reported in an upcoming issue of chondria might lend a partial the journal Biochemistry and now explanation to a pattern discerned available through advance online in studies of ischemic heart pa- Research finds differences in gene usage publication, may have implica- tients, who have restricted blood tions for human cardiovascular flow to the heart. health. "While we have to be careful in dramatically change bacteria's 'lifestyles' In its studies of mouse heart drawing definitive parallels be- muscle, the research team found tween mouse lipid dynamics and BY MICHAEL C. PURDY ed to understanding how the bac- into E. coli, the bacteria gained levels of two members of a class human lipid dynamics, it is inter- teria might use identical genes the ability to resist polymyxin B of lipids (fatty molecules) called esting to note that the majority of When and where a bacteri- differently. in low magnesium environments. phospholipids fell dramatically sudden death in ischemic heart um uses its DNA can be as Salmonella and E. coli share Based on data still to be pub- when food was withheld. For one patients occurs in the early morn- important as what's in the the gene for an antibiotic resist- lished, Groisman suspects that type of phospholipid, levels de- ing hours when people have typi- DNA, according to School of Me- ance regulatory protein called many other aspects of microbial creased by 20 percent after only cally had a long fast and are sub- dicine researchers. PmrA. By controlling when other lifestyle are affected by differences four hours of fasting; and for the ject to a vast array of hormonal Scientists found significant proteins are produced, PmrA can in regulation of identical genes. other, levels dropped a remarkable influences during the sleep-wake differences in two bacterial or- make the cell wall more resistant He notes that the idea of dif- 40 percent after 12 hours of cycle," Gross said. ganisms' use of a gene linked to to damage from the antibiotic ferent organisms making altered fasting. "The alterations in heart mus- processes that govern a form of polymyxin B. use of the same genes sprang The changes in phospholipids cle energy utilization during fast- antibiotic resistance. The distinc- The PmrA protein normally from recent analyses of the hu- occurred mainly in the mitochon- ing may setup a deleterious situa- tion alters the bacteria's "life- activates in response to high iron man genome. dria, which are highly abundant in tion in the hearts of ischemic styles," or their ability to survive levels. "Humans not only appear to heart muscle cells and account for heart patients." in different environments. In a paper recently published have far fewer genes than expect- most of the phospholipid content The research team uncovered Researchers say the finding in Genes and Development, Grois- ed, there also seem to be fewer of the cells. Mitochondria serve to the fluctuations in cellular lipids shows that understanding such man's lab established that another genes that are unique to human break down many types of fats to through an innovative new tech- changes will likely help develop- protein, PmrD, also can activate DNA than anticipated," Grois- produce the high-energy cellular nology it developed called "shot- ment of new treatments for dis- PmrA in response to low magne- man said. fuel ATP, which is essential for a gun lipidomics." As the name sug- ease-causing microorganisms. sium levels. In addition to instructions for multitude of cellular processes, gests, in comparison to other "These differences in gene In the new study, Groisman's building proteins, DNA contains including the regular contraction techniques, shotgun lipidomics usage are harder to look for, but lab discovered that E. coli has a stretches of code that affect when of the heart muscle. has the speed and coverage of a we're not going to understand different version of PmrD that is genes are turned on and off. As "What we measured was a mas- shotgun blast. From a simple one- these organisms fully unless we unable to turn on the PmrA pro- life becomes more complex over sive change in heart lipid composi- step extraction of lipids in tissues, take into account this other di- tein in response to low magne- the course of evolution, Groisman tion," Gross said. "In part, it con- the team can obtain in minutes mension," said senior investigator sium. said, these regulatory sections firms what science has come to rec- highly accurate measurements of Eduardo Groisman, Ph.D., pro- "We're not really sure what the appear to take up larger portions ognize — mitochondria are quite the various cellular lipids, which fessor of molecular microbiology significance of low magnesium is, of the DNA, allowing genes to be dynamic and change shape in re- previously have been notoriously and a Howard Hughes Medical but there are some indications turned on and off in ways that are sponse to nutritional and hormon- fragile, time-consuming to analyze Institute investigator. that it may be important to the more intricately responsive to the al cues. But we are the first to re- and hard to quantify. The study appeared the week bacteria's ability to survive in environment and other factors. port that mitochondria essentially ■ "Through the efforts of people of Nov. 29 in the online edition white blood cells or outside of Human DNA, Groisman spec- remodel their own membranes, in our division like Xianlin Han, of the Proceedings of the National the host in soil or water," Grois- ulated, may be heavily packed and thereby their physical proper- who has worked hard to perfect Academy of Sciences and in print man said. with the factors that allow a more ties, by dynamically altering their the technology, we have been able Dec. 7. When scientists transplanted complex, richer use of genes also use of phospholipids." to open up fresh avenues of inves- One of the bacteria studied, the Salmonella form of PmrD found in other organisms. A phospholipid decrease of the tigation using shotgun lipido- Salmonella enterica, is a leading magnitude reported is all the mics," Gross said. cause of food poisoning and ill- ness related to animal husbandry. The other, Escherichia coli, can cause illness but more typically Record (USPS 600-430; ISSN 1043-0520), Cooper honored by British surgical society plays a beneficial role in the hu- Volume 29, Number 17/Dec, 10,2004. man digestive system. - Founded in 1905 Published tor the faculty, staff and Washington University community news BY GILA Z. RECKESS include leading The two are closely related ge- of Washington University. Produced weekly the team that netically. Less than 20 percent of Editor Kevin M. Kiley during the school year, except school Joel D. Cooper, M.D., the Evarts performed the E. coli's genes are not found in Associate Editor Andy Clendennen holidays, and monthly during June, July Assistant Editor Neil Schoenherr A. Graham Professor of Sur- Salmonella and just over 25 per- and August by the Office of Public Affairs, first successful Associate Vice Chancellor Judith Jasper Leicht Washington University, Campus Box 1070, gery and chief of the Division of lung transplant cent of Salmonella's genes lack Executive Editor Susan Killenberg McGinn One Brookings Drive, St. Louis, MO 63130. Cardiothoracic Surgery, has been in the world in counterparts in E. coli. Medical News Editor Kimberly Leydig Periodicals postage paid at St. Louis, MO. awarded an honorary fellowship 1983, and then Groisman's research had pre- Production Carl Jacobs of the Royal College of Surgeons leading the first viously focused on how differ- News t Comments Where to send address changes of England, which is internation- successful dou- ences in gene content made Sal- (314) 935-6603 Postmaster and nonemployees Record, ally recognized as one of the Cooper ble lung trans- monella a persistent source of ill- Campus Box 1070 Washington University, Campus Box 1070, [email protected] world's leading authorities in plant in 1986. ness. He identified several areas in One Brookings Drive, St. Louis, M0 63130. Medical News surgery. He also pioneered a procedure the bacteria's DNA known as Employees Office of Human Resources, (314)286-0119 Cooper was presented this dis- called lung-volume reduction sur- "pathogenicity islands" — clus- Washington University, Campus Box 1184, Campus Box 8508 One Brookings Drive, St. Louis, M0 63130. tinction in a recent ceremony at gery, in which surgical removal of ters of genes unique to Salmonella [email protected] the Royal College Headquarters the most-damaged portions of that help it cause illness. in London. the lung dramatically improve When complete gene maps for Cooper's extensive accom- quality of life for patients with both bacteria became available in IS ^JvfehingtonUniversity in StLouis plishments in lung surgery severe emphysema. recent years, his interests expand- 4 RECORD WASHINGTON UNIVERSITY IN ST. LOUIS University Events Callaway, Graae to bring evening of cabaret Jan. 15

BYLIAMOTTEN Grill, for which she received both a Off-Broadway shows include Hello Muddah, Hello nomination and a Drama League Award nomination. Fadduh (for which he received a Drama Desk Nomination), Between them, singers and Jason Graae Sibling Revelry, a cabaret show she created with sister, Forever Plaid, Olympus on My Mind, All in the Timing and boast 11 Broadway shows, more than 65 recordings Ann Hampton Callaway, was recorded live for DRG Re- many more. and dozens of and television appearances. cords and won both a Back Stage Bistro Award and a MAC In , he spent a year as Houdini in the U.S. They also boast a friendship that has survived more Award from the Manhattan Association of Cabarets & premiere of , won an Ovation Award for Forbidden than 20 years of showbiz. (The pair met as cast-mates in a Clubs. Broadway Y2KLA! and was recently nominated for a second 1980 off-Broadway production of . Callaway was Callaway can be heard on more than 30 recordings, Ovation for the role of Moonface in the revival of Anything paid $18 per week. St. Louis native Scott Bakula starred as including three solo albums: The Beat Goes On (featuring Goes! Jesus.) music of the '60s), The Story Goes On: Liz Callaway On and Graae made his opera debut as Njegus in The Merry At 8 p.m. Jan. 15, Edison Theatre's OVATIONS! Series Off-Broadway and Anywhere I Wander: The Music of Frank Widow with the and his Metropolitan will present these "musical pals" in Back- Loessor. Opera House debut as vocal soloist in 's Ever- stage Broadway Buddies, an intimate She performed the title character's last. He has recorded more than 35 original cast albums cabaret-style evening of standards and singing voice in the animated feature and studio CDs, including two solo discs, You're Never Fully stories, solos and duets, gossip and sen- Anastasia, and her song "Journey to the Dressed Without A Smile: Jason Graae Sings timent. Past" was nominated for a 1998 Academy and Jason Graae: LIVE At The Cinegrill. Callaway, who performed at Edison Award. On television, he has been featured as Dennis on HBO's Theatre in 2002 with Godspell composer Other film work includes the singing Six Feet Under and also appeared on Rude Awakening, Stephen Schwartz, is a Chicago native and voice of Princess Jasmine in Disney's The Friends, and Sabrina the Teenage Witch, among daughter of journalist John Callaway. Return ofjafar and Aladdin and the King many others. of Thieves as well as vocals for The Swan Graae has been featured twice with the Boston Pops on She made her Broadway debut in Callaway Graae 's Merrily We Roll Princess, Lion King 2: Simba's Pride, Beauty PBS, and for five years he was the voice of Lucky Charms Along and has also appeared in The Three and the Beast and The Brave Little Toaster Cereal's Lucky the Leprechaun. Musketeers; Miss Saigon, for which she originated the role Goes to Mars. Recent film roles include the Disney animated feature of Ellen; Baby, for which she earned a Tony Award nomi- She received an Emmy Award for hosting Ready To Go, a Home on the Range and the forthcoming On Edge with nation; and Cats, where she spent five years playing Griz- daily children's program on CBS in Boston. Jason Alexander. abella. Graae, dubbed "the undoubted master of humorous Tickets — $28; $24 seniors and WUSTL faculty and staff, In addition to Godspell, Callaway has appeared off- song" by New York Magazine, has starred on Broadway in A $18 for students and children — are available at the Edison Broadway in The Matinee Kids, 1-2-3-4-5, No Way To Treat Grand Night For Singing, , Stardust, Snoopy! and Do Theatre Box Office and through all MetroTix outlets. a Lady, Brownstone, Marry Me A Little and The Spitfire Black Patent Leather Shoes Really Reflect Upl For more information, call 935-6543. Blood Drive • How We Sense Infection • Mouse Models

"University Events" lists a portion of the activities taking place Dec. 10-Jan. 24 How to submit at Washington University. Visit the Web for expanded calendars for the Hilltop Campus 'University Events' (calendar.wustl.edu) and the School of Medicine (medschool.wustl.edu/ Submit "University Events" items calendars.html). to Genevieve Podleski of the Record staff via: (1) e-mail — recordcalendar Exhibits ©wustl.edu; (2) campus mail — Architecture Exhibition. Soccer field com- Campus Box 1070; or petition student entries. Through Dec. 20. (3) fax —935-4259. Givens Hall. 935-6200. Deadline for submissions is noon on the Thursday eight days Lectures prior to the publication date. Series. Basic Research Seminar. Jim Lederer, dept. of surgery. Harvard U. Friday, Dec. 10 Clinical Science Research Bldg., Rm. 9:15 a.m. Pediatric Grand Rounds. "Res- 5550. 362-8560. piratory Viruses for the 21st Century — 4 p.m. Medical Humanities & Social Three Stories." Gregory Storch, prof, of Science Talk. 'Taking the 'Nox' Out of pediatrics, of medicine and of molecular Nocumentum: Poisons, Drugs and Side microbiology. Clopton Aud., 4950 Effects in Thirteenth- and Fourteenth- Children's Place. 454-6006. century France." Walt Shalick, prof, of Noon. Cell Biology & Physiology Seminar. history and of pediatrics. Brookings Hall, "RGS Proteins —Functions and Thera- Rm. 100. 935-5340. peutic Potential." Richard R. Neubig, prof, of pharmacology, U. of Mich. McDonnell Wednesday, Dec. 15 Medical Sciences Bldg., Rm. 426. 362-1668. 4 p.m. Biochemistry & Molecular Bio- physics Seminar. "Beyond Crystallo- Through the perilOUS fight The Concert Choir of Washington University, under the direction 4 p.m. Dept. of Music Lecture. "Onyx Club graphy, Functional Protein Dynamics of John Stewart, director of vocal activities in the Department of Music in Arts & Sciences, per- : Jazz and White Masculinity in the From Site-directed Spin Labeling." Early Swing Era." Patrick Burke, asst. Wayne Hubbell, prof, of chemistry & forms the national anthem before the Dec. 5 NFC battle between the St. Louis Rams and the San prof, of music. Music Classroom Bldg., biochemistry and of ophthalmology, Francisco 49ers at the Edward Jones Dome. The 80-some members of the choir, which will also Rm. 102.935-4841. U. of Calif., Los Angeles. Cori Aud., be in concert at 8 p.m. tonight in Graham Chapel, remained to watch the game from the sidelines. 4565 McKinley Ave. 362-0261. The Rams won, 16-6. Saturday, Dec. 11 8:30 a.m.-3 p.m. Internal Medicine CME Thursday, Dec. 16 Course. "Coding for Physician Services: Noon. Genetics Seminar Series. Thursday, Jan. 6 Monday, Jan. 17 Hospital Setting." Cost: $165 for physi- "Algorithmic Improvements in Linkage Noon. Center for Health Policy Ethnic & cians, $140 for allied health profession- Analysis: Modeling Genotyping Error 7 p.m. University Commemoration Music Racial Disparities in Health Care Brown Celebration for Martin Luther King Jr. als. Eric P. Newman Education Center. To and Linkage Disequilibrium." Goncalo Bag Seminar Series. "Telemedicine to register: 362-6891. Abecasis, asst. prof, of biostatistics, U. of "Be the Change." Graham Chapel. Improve Care and Reduce Disparities in Mich. McDonnell Medical Sciences Bldg., 935-5970. Friday, Dec. 10 Monday, Dec. 13 Rm. 823.362-2139. Rural Missouri." Karen Edison, Center for 8 p.m. Concert. Concert Choir of Washing- Health Policy, U. of Mo. Simon Hall, Rm. ton University. John Stewart, dir. Perfor- 4 p.m. Cell Biology & Physiology Lecture. Wednesday, Jan. 19 Noon. CSNSI & Neurology Research Se- 241.935-9108. mance dedicated to the memory of Erlanger-Gasser Lecture. "Mouse Models minar. Kelvin Yamada, assoc. prof, of 11 a.m. School of Law "Access to Jus- William R. Kohn, prof, emeritus in the for Cancer." Anton I.M. Berns, prof., neurology, asst. prof, of pediatrics. Ma- Monday, Jan. 10 tice" Public Interest Law Speakers School of Art. Graham Chapel. 935-4841. ternity Bldg., Schwartz Aud. 362-9460. Nederlands Kanker Institut, Amsterdam. Series. Black Law Students Association McDonnell Medical Sciences Bldg., Rm. 4 p.m. Immunology Research Seminar Martin Luther King Jr. Commemorative 4 p.m. Immunology Research Seminar 426. 362-6812. Series. "Cancer Immunoediting: Mole- Speaker. "Dr. Martin Luther King Jr.'s Monday, Dec. 13 Series. "Poised on a Knife Edge: Balan- cular Mechanisms and Therapeutic Legacy: An Economic Justice Imper- cing Immunity Versus Virulence During 8 p.m. Concert. Flute Choir. Jan Smith, dir. Implications." Robert D. Schreiber, ative." Susan R. Jones, prof, of clinical Graham Chapel. 935-4841. Chronic Herpesvirus Infection." Herbert Friday, Dec. 17 Alumni Professor of pathology & im- law, George Washington U. Anheuser- "Skip" Virgin, prof, of pathology & im- 9:15 a.m. Pediatric Grand Rounds. "Hy- munology. Eric P. Newman Education Busch Hall. 935-4958. 8 p.m. Concert. Small Chamber Ensemble munology. Eric P. Newman Education pertension: Managing Without a Nephro- Center. 362-2763. Extravaganza. Elizabeth Macdonald, dir. Center. 362-2763. logist?!" Anne Beck, asst. prof, of pedi- Sunday, Jan. 22 Holmes Lounge. 935-4841. atrics. Clopton Aud. 4950 Children's Thursday, Jan. 13 Tuesday, Dec. 14 Place. 454-6006. 3 p.m. Business Minority Council presen- Friday, Dec. 17 4 p.m. Ophthalmology & Visual Sciences tation. Martin Luther King Jr.'s contribu- 8:30 a.m.-4:30 p.m. Center for the Appli- Monday, Dec. 20 Seminar. "Immunologic Control of HSV- tion toward equality in education and the 8 p.m. Washington University Opera. cation of Information Technology Two- 1 Latency and Implications for Herpes workplace and his effect on African- Winter Evening of Opera. Jolly Stewart, day Workshop. 'The Politics of IT Project Noon. Molecular Biology & Pharmacology Keratitis." Robert L. Hendricks, prof, of Americans in the business world. Simon dir. Umrath Hall Lounge. 935-4841. Management." (Continues 8:30 a.m.-4:30 Seminar. "Molecular Assembly of Hippo- ophthalmology, of immunology and of Hall. 935-7301. p.m. Dec. 15.) Cost: $1,195, reduced fees campal Synapses." Ann Marie Craig, molecular genetics & biochemistry, U. of • Sunday, Dec. 19 available for CAIT organizations. CAIT, 5 assoc. prof, of anatomy & neurobiology. Pittsburgh. Cori Aud., 4565 McKinley N.Jackson Ave. 935-4444. South Bldg., Rm. 3907, Philip Needleman Ave. 362-1006. Monday, Jan. 24 3 p.m. Choral Sing-along. Handel's Library. 362-0183. 4 p.m. Immunology Research Seminar Messiah. John Stewart, dir. Graham Noon. Molecular Microbiology & Miero- 7:30 p.m. American Technion Society Series. "How We Sense Infection: Toll- Chapel. 935-4841. bial Pathogenesis Seminar Series. Lecture. "Research Towards Under- like Receptors and the Forward GenetJc "TRIM5alpha: A Mediator of Innate standing and Preventing Irregular Hearth Tuesday, Dec. 21 Analysis of Innate Immunity." Bruce Intracellular Resistance to Retroviruses." Rhythms and Sudden Death." Yoram Sunday, Jan. 23 Joseph G. Sodroski, prof, of pathology, 4 p.m. Anesthesiology Research Seminar Beutler, prof, of immunology, Scripps Rudy, Fred Saigh Distinguished Professor 8 p.m. Organ Concert. In celebration of Dana-Farber Cancer Inst, Harvard U. Cori Series. Ling-Gang Wu, National Insti- Research Inst. Eric P. Newman Education of Biomedical Engineering. Whitaker Hall. the Graham Chapel renovation. James Aud., 4565 McKinley Ave. 747-2132. tutes of Health, Bethesda, Md. Clinical Center. 362-2763. Sciences Research Bldg., Rm. 5550. To register: 725-7330. Kibbie, organist, U. of Mich. Graham 4 p.m. Anesthesiology Research Seminar 362-8560. Chapel. 935-4841. record.wustl.edu WASHINGTON UNIVERSITY IN ST. LOUIS Dec. 10,2004 5 'Tis the season Music ensembles to present concerts throughout December

The Department of Music in Lounge. The performance will welcome to attend. Copies of the Arts 8c Sciences will conclude also feature additional Mozart music will be available for those its fall season with a host of arias weaved into the story line. who do not bring their own December concerts. Finally, the music department scores. The Concert Choir of Wash- will host its annual sing-along of John Stewart will direct the ington University — under the George Frideric Handel's oratorio performance; William Partridge direction of John Stewart, director Messiah at 3 p.m. Dec. 19 in will be the organist. Soloists will of vocal activities — will perform Graham Chapel. be all students or recent graduates works composed across six cen- The performance, which will of the music department's Vocal turies at 8 p.m. today in Graham last about an hour, will include Performance Program; they will Chapel. The performance will be the Christmas portion of Messiah include soprano Megan Higgins; dedicated to former choir member ■ as well as the "Hallelujah Chorus." mezzo-soprano Deborah Stinson; William R. Kohn, professor emeri- Those who wish to may sit in tenor Clark Sturdevant; and bari- tus in the School of Art, who pas- special sections arranged accord- tone Nathan Ruggles. sed away Nov. 13. ing to voice type (soprano, alto, All concerts are free and open Representing the Renaissance is tenor, baritone), though those to the public. For more informa- Tomas Luis de Victoria's famed "O who choose not to sing are also tion, call 935-4841. Magnum Mysterium," followed by a contemporary setting of the same tune by American composer Morten Lauridsen. Also in the concert are works by Baroque composers Thomas Galumpha, a New York-based dance trio that combines physical Weelkes and Antonio Lotti; by comedy, acrobatic choreography and striking visual effects, will come to Edison Theatre Jan. 15 as part of the ovations! for young 19th- and 20th-century com- people series. posers Charles V. Stanford, Sergei Rachmaninoff, Francis Poulenc and Joseph Canteloube; and a 2003 setting of "My Soul's Been ovations! for young people Anchored." At 8 p.m. Dec. 13, the music department will present a "Small presents Galumpha Jan. 15 Chamber Ensembles Concert" in Holmes Lounge. Elizabeth Mac- BYLIAMOTTEN The duo's performing and donald, director of strings, will choreographic credits include conduct the performance, which A three-headed human fly? To- Serious Fun at Lincoln Center in will feature a variety of small stu- tem poles that come to life? New York; Just for Laughs in Mon- dent-chamber ensembles. The Velcro-helmeted weirdoes who treal; The Staat Schowberg in Am- program will include string quar- defy the laws of physics? sterdam; Man-Made at New York's tet selections by Franz Schubert, Is this a horror movie or a Joyce Theater; Ireland's Galway Antonin Dvorak and Maurice comic book? Arts Festival; and Spoleto-USA in Ravel; "Cries of London" for viols No, it's Galumpha, a New Charleston, S.C., among many and voice by Thomas Weelkes; York-based dance trio whose dar- others. and tangos for cello, arranged by ing combination of physical com- Other projects range from Macdonald. edy, acrobatic choreography and "Ecstasy," an MTV video with the Also at 8 p.m. that evening, striking visual effects is quickly band Rusted Root, to a Japanese the Washington University Flute earning a national following. television commercial, the British Holiday print Sale Island Press, the School of Art's nation- Choir, directed by Jan Smith, will In January, the troupe will game show The Generation Game ally renowned professional printshop, will host its second- perform a concert in Graham descend upon St. Louis for a spe- and more than 1,000 workshops annual holiday sale from 11 a.m.-4 p.m. Dec. 19 in Blxby Hall. Chapel. cial, one-time-only matinee at and lecture demonstrations for The event will feature works by dozens of Internationally The Washington University renowned artists — including James Barsness, Chakala Edison Theatre. children. Opera, directed by Jolly Stewart Booker, Michael Byron, Hung Liu, Shimon Okshteyn, Franco The performance, presented as As Galumpha, Horowitz, and conducted by John Stewart, Mondini Ruiz, Jane Sauer and Catherine Wagner — at dis- part of the Edison Theatre ova- O'Brien and Torres have toured will present Mozart's short comic counts of 30 percent to 50 percent off list prices. Among the tions! for young people series, will widely, performing at venues opera The Impresario at 8 p.m. works offered will be Louie Louie (above), a soft-ground etch- begin at 11 a.m. Jan. 15. around the world and earning a Dec. 17-18 in Karl Umrath Hall ing by Rocky Toner. For more information, call 935-6571. According to anthropologists, prestigious Edinburgh Festival "galumphing" is the manifestation Critic's Choice Award. They have of the seemingly inexhaustible been featured on MTV, Showtime, store of play-energy one finds in A8cE and The Late Show With children, puppies, kittens and David Letterman, among many other higher fife forms. others, and in Jerry Lewis's 2002 Sports "We galumph when we hop Muscular Dystrophy Association instead of walk," writes Stephen Telethon. fell in the opening game of the Nachmanovitch in Free Play: Ovations! for young people Swimmers, divers [iff tournament to Benedictine Improvisation in Life and Art, presents affordably priced — and shatter school records "when we take the scenic route family friendly — matinee shows University, 100-95. The men's and women's swimming For complete sports schedules and instead of the efficient one." by nationally and internationally The Bears broke the record of and diving teams continued their results, go to bearsports.wustl.edu. Galumpha the dance company recognized performing artists. 15 3-pointers, which they reached strong performances at the Whea- three times. Senior Rob Keller fin- delivers a fast-paced, athletic mix The series compliments the signa- ton College Invitational. The IM (2:08.97). She was a part of ished the game with a career-high of art and entertainment, obliter- ture Edison Theatre OVATIONS! women broke two more school four school records and seven ating boundaries between the series, which serves both the 26 points while junior Mike Grunst records on the final day of compe- NCAA qualifying times for the ridiculous and the sublime. University and the St. Louis com- had a career-high 19 points. tition, bringing their two-day total weekend. The troupe was formed in munity by providing the highest In the consolation champion- to six, en route to a third-place Juniors Michael Slavik and ship, the Bears improved to 4-3 2002 by Andy Horowitz and Greg caliber national and international finish at the Invitational. The Eric Triebe paced the men's with an 86-70 win over Principia O'Brien, artists-in-residence at artists in music, dance and the- women posted 591 points, behind squad. Both swimmers provision- College Dec. 4. WUSTL followed Binghamton University. Rounding ater, performing new works as University of Wisconsin-Milwau- ally qualified for the NCAAs in out the team is Marlon Torres, a well as innovative interpretations record 3-point performance with kee (600) and host Wheaton two freestyle events: Slavik in the former child television star in his of classical material not otherwise 12 more against Principia. (801.5). 50 free (21.13) and 200 free native Venezuela. seen in St. Louis. Michael Faherty led five Bears The men placed fourth with (1:42.07) and Triebe in the 50 free Horowitz and O'Brien have Edison Theatre programs are in double figures with 15 points. 539 points, behind University of (21.01) and 200 free (1:43.00). performed together for more than supported by the Missouri Arts Wisconsin-Stevens Point (580), A day earlier, both competitors 20 years, having met as students at Council, a state agency, and the Women's hoops team UW-Milwaukee (710.5) and earned NCAA "B" cuts in the 100 Binghamton (then the State Uni- Regional Arts Commission, Wheaton (760.5). free. The 200-medley relay squad wins two more games versity of New York-Binghamton) St. Louis. Freshman Tina Deneweth set a of Slavik, Triebe, freshman Geoff The No. 4 women's basketball in 1982. They formed their first Tickets are $7 and are available school record in the 100-yard but- Hart-Cooper and junior Alex team won a pair of games at the troupe, The Sticks, in 1986 and in at the Edison Theatre Box Office terfly, recording a time of 57.01. Antilla posted a time of 1:34.96 to Colorado College Classic. With the 1987 commenced a 15-year run and through all MetroTix outlets. The mark also automatically quali- earn an NCAA "B" cut. two wins, the Bears improved to with dancer Paul Gordon as The For more information, call fied her for the NCAA Champio- Slavik, Antilla, sophomore 7-0. WUSTL defeated host Colo- Second Hand Dance Company. 935-6543. nships. The second women's David Stein and Triebe also rado College, 79-60, Dec. 3. Alicia record that fell on the day came teamed up in the 400-free relay to Herald paced the Bears with a ca- courtesy of the 200-medley relay provisionally qualify with a time reer-high 20 points and eight re- & 3:30 p.m. Dec. 12.) Cost: $20. Mudd Monday, Jan. 24 Hall Multipurpose Room. 935-6098. team. The foursome of freshman of 3:06.73. bounds. Senior Kelly Manning fin- I p.m. Concert. Washington University Meredith Nordbrock, junior Allie On the weekend, the women ished with 18 points, six rebounds, Chamber Orchestra. Elizabeth Macdonald, Tuesday, Jan. 11 Boettger, Deneweth and junior broke six school records and post- four assists and three steals. dir. Umrath Hall Lounge. 935-4841. Jenny Scott clocked an NCAA "A" ed 14 NCAA qualifying times. WUSTL wasted little time tak- 1-2:30 p.m. Center for Mental Health Services Research Open House. Brown cut time of 1:47.28. The men set a pair of school re- ing control of the next day's 86-42 Hall Lounge. 935-5687. Nordbrock and Scott also auto- cords and tallied 10 NCAA quali- win against Pomona-Pitzer Col- matically qualified for NCAAs in fying times. leges. The Bears tallied the game's And more... Monday, Jan. 24 an individual event. Nordbrock first 11 points, led by Danielle Beehler's six points during the 11:30 a.m.-4:30 p.m. Blood Drive. Co- took first place in the 100 back- Men's basketball team Friday, Dec. 10 sponsored by Phi Delta Theta fraternity stroke. Scott earned an NCAA "A" run, en route to a 48-16 halftime 7 p.m.-1 a.m. Tango/Swing/Salsa Dance and Kappa Kappa Gamma sorority. (Also cut in the 200 free with a time of takes third place cushion. Beehler finished with 13 Event. Umrath Hall Lounge. 935-6098. 11:30 a.m.-4:30 p.m. Jan. 25, Mallinc- 1:53.59. The men's basketball team won points in 19 minutes of action. In krodt Student Center, Lower Lvl. The Nordbrock set two school the consolation championship at all, 12 players scored for WUSTL. Gargoyle, and 5-10 p.m. Jan 26 & 27, Saturday, Dec. 11 Wohl Student Center, Friedman Lounge.) records on the first day of the the Bill Merris Tip-Off Classic in Senior Nicole Wylie matched 2 & 3:30 p.m. Tango Workshop. Brigitta Mallinckrodt Student Center, Lower Lvl., Invitational; she broke the mark in Jacksonville, 111. Despite a school- Beehler with a game-high 13 Winkler, tango instructor, Berlin. (Also 2 The Gargoyle. 291-4741. the 200 back (2:08.06) and the 200 record 16 3-pointers, the Bears points off the bench. 6 RECORD WASHINGTON UNIVERSITY IN ST. LOUIS

The company is aggressively the Olin Cup competition were The Skandalaris Center for marketing the technology for out- selected from the St. Louis com- Entrepreneurial Studies is one of Lab Olin licensing while pursuing drug dis- munity as well as nationally, Har- the Top 25 business-school entre- - from Page 1 - from Page 1 covery-based in-house research rington said, and were matched preneurship programs nation- designed to capture sizeable por- with Olin School teams. More wide, based upon Entrepreneur tions of the degenerative disease than 50 business-school teams Magazine's comprehensive rank- weak enough to serve as vac- porate partners who are interested market and bring a minimum of registered in this year's compe- ings. It is a member of the Ewing cines." in the promotional aspects of our 25 times return on investment in tition. Marion Kauffrnan Foundation According to the U.S. Centers program, including prominent the next five years. Ten teams made it to the semi- National Consortium for Life for Disease Control and Preven- representation on the new Olin The Blessing Basket Project finalist round; five teams were Science Entrepreneurship. tion, noroviruses are involved in Cup Web site." was founded by Theresa Wilson, selected as finalists. The Kauffrnan Foundation about half of all food poisoning One of the primary goals of whose team includes Olin School Those finalists made two- cases and annually cause about recently selected WUSTL as one the Olin Cup competition, Har- undergraduate and graduate stu- minute "elevator pitches," pre- 23 million cases of acute gas- of eight U.S. universities to share rington said, is "cross-campus col- dents. The first nonprofit entry in pared detailed business plans and $25 million in grants through a troenteritis in the United States. laboration" among WUSTL's top- Olin Cup history, The Blessing made final presentations to the Norovirus disease is character- program designed to make entre- ranked business, medical, law, Basket — 501 (c)3 pending — is a Olin Cup judges. ized by frequent vomiting and preneurship education available engineering and other schools social entrepreneurship venture "The Olin Cup competition diarrhea over the course of 1-2 across campus and transform the and among the vibrant and started more than a year ago in adds to the vibrant St. Louis start- days. The most infamous noro- way entrepreneurship is viewed, diverse business community lead- pilot locations in six developing up community," Harrington said. taught and experienced. WUSTL virus, the Norwalk virus, was first ers in the St. Louis area. countries. "It's truly amazing to see how identified after a 1968 outbreak received a grant of $3 million. Luminomics was founded by The Blessing Basket pays wea- quickly companies form when at a school in Norwalk, Ohio. Jeffrey S. Mumm, Ph.D. The com- vers in undeveloped countries the people from different disciplines The Norwalk virus also caused a pany creates disease models and prosperity wage (which is multi- create a collaborative environ- series of repeated outbreaks on performs high-throughput screens ples higher than the local aver- ment." cruise ships in 2002 and in mili- to discover small molecules that age), imports high-quality baskets The annual Olin Cup Compe- tary personnel in Afghanistan. stimulate cellular regeneration. and sells them via its Web site, tition was founded in 1987 as part Although such infections rare- Center Lead compounds capable of stim- direct sales and retail relation- of The Hatchery entrepreneurship ly lead to serious or life-threaten- ulating regeneration in the mo- ships. Revenues above expenses course at the Olin School. The Opened in 1994; has ing illness in the United States del system will be used to iden- are reinvested into additional pro- Olin Cup competition as a sepa- and other Western countries, they done pioneering work tify regenerative therapies for duct and economic/community rate entity was launched in 2002, spread rapidly, are difficult to humans. development projects. with a new emphasis on life sci- - from Page 1 prevent from spreading and can Luminomics is focused on four Core Devices, founded by John ences, medicine and technology create considerable discomfort. major neurodegenerative disor- Izuchukwu, received an honorable startups, as well as other student- Dehydration from the diarrhea health care has enormous ders, but the platform can be mention for its portable anesthe- started ventures. and vomiting induced by the potential to ensure treatment applied to any degenerative dis- sia machine. The machine is de- To date, the competition has virus sometimes leads to hospi- to persons whose disorder ease state or condition, said signed to facilitate the delivery of resulted in the formation of more talization in the elderly, the currently goes undetected, to Mumm, who earned a doctorate care outside traditional hospital than 50 new businesses by Olin young or those with weakened extend evidence-based care to in biology and biomedical sci- settings. School business students and immune systems. those who have been poorly ences from the University. Ac- Likely applications include alumni. In the developing world, these served and to reduce racial cordingly, the company is partner- civilian and military operations, An event Feb. 10 will mark the viruses are a major cause of hu- disparities in care." ing with other companies to pro- as well as private physician clinics, opening of registration for new man illness. CMHSR opened in 1994 as vide tailor-made disease models rural hospital settings and austere teams for the next Olin Cup entre- All previous attempts to cul- the nation's first NIMH-fund- and screening-outsource services environments anywhere in the preneurship competition. Teams ture human noroviruses in tis- ed social work research devel- for their specific degenerative world. may then register at www.olin sues in the laboratory have been opment center. Its research targets. Judges and team mentors for .wusd.edu/cel/olincup/register.cfrn. unsuccessful. projects represent some o: the "As a group, noroviruses have pioneering clinical epidemio- defied characterization for de- logical, service-systems and cades because there just hasn't quality-of-care research in been a way to get the virus to Reactor mental health and social grow outside of a human host," from Page 1 services. Virgin said. The center's future work In 2003, Christianne Wobus, will build on its prior decade Ph.D., and Stephanie Karst, unbounded water was converted of mental-health research in Ph.D., two postdoctoral fellows to steam, decreasing the thermal the social services. in Virgin's lab, identified MNV-1, neutron flux and making the reac- "The center's research the first known mouse norovirus. tor sub-critical." agenda is built around pro- Virgin's group showed that the ("Critical" means that a fis- jects with Missouri's Child- mice's ability to fight MNV-1 sionable material has enough mass ren's Division and Division of relied heavily on the innate im- to sustain a reaction.) Senior Services and Regula- mune system, the branch of the "It took at least 2.5 hours for tion," said J. Curtis McMillen, immune system that attacks in- the reactor to cool down until fis- Ph.D., center associate director vaders soon after they enter sion Xe (xenon) began to retain," and associate professor of the body. the researchers continued. "Then social work. In the newly published study, the water returned to the reactor "It includes a range of pro- Virgin's group reveals that MNV- zone, providing neutron modera- jects and studies designed to 1 likes to infect cells of the innate tion and once again establishing a Alexander Meshik holds a tiny piece of rock from the only known enhance quality improvement immune system. In tests in mice, self-sustaining chain." natural nuclear chain reaction site in the world — in Gabon, West research methodology. With the researchers found the virus Prior to this calculation, it was Africa. Olga Pravdivtseva and University colleague Charles Hohen- this new center, we are moving thrived in macrophages, im- known that the natural nuclear berg collaborated on an isotoplc analysis of a tiny portion of the from studying how mental- mune-system cells that normally reactor operated 2 billion years sample that reveals how this natural nuclear reactor worked. health issues are handled in engulf and destroy pathogens, ago for 150 million years at an these sectors of care to devis- and in dendritic cells, sentry-like average power of 100 kilowatts. from the Oklo mine was depleted noted the importance of alu- ing and implementing strate- cells that pick up and display The WUSTL team solved the mys- in 235 Uranium, it was discovered mophosphate in the natural nu- gies to improve services. proteins from pathogens. tery of how the reactor worked and that the site had once been a nat- clear reactor. "Ultimately, we hope to "We think there may be den- why it didn't blow up. ural nuclear reaction system. "More krypton 85, a major develop system modifications dritic cells just beneath the lining Meshik and his collaborators, "The big question we addres- waste from modern nuclear reac- for public social-service agen- of the human gut that are pro- Charles M. Hohenberg, Ph.D., sed was: When it reached critical- tors, is getting piped into the at- cies that will result in better viding the gateway the virus professor of physics, and Olga ity, why didn't it blow up?" Me- mosphere each year," he said. detection of mental disorder needs to cause disease," Virgin Pravdivtseva, Ph.D., senior re- shik said. "We found the answer "Maybe this natural mode can and access to treatment." said. search scientist in physics, used a in the xenon." suggest a safer solution." In addition to Proctor and To grow the virus in the lab, selective laser combined with sen- There were two major theories Can there be a natural nuclear McMillen, CMHSR's investiga- researchers took dendritic cells sitive, ion-counting mass spec- on how the reactor operated. One reactor in actual operation today? tors include 35 Ph.D./M.D- and macrophages from mice with trometry to concentrate on the held that the system burned up "Today, even the largest and level researchers from around defective innate immune systems sample's moderator, a uranium- highly neutron-absorbing impuri- richest uranium deposit cannot the University and across the and exposed them to the virus. free mineral assembly of lan- ties such as rare Earth isotopes or become a reactor because the nation. "The virus grew beautifully," thanum, cerium, strontium and boron, and because of that the sys- present concentration of 235 U is The center has engaged the Virgin said. "It's a very facile and calcium called alumophosphate. tem shut down regularly, and dif- too low — only about 0.72 per- expertise of a variety of disci- robust system." The xenon found and analyzed ferent parts of the reactor might cent," Meshik said. "However, plines, including social work, Comparisons of MNV-1 and provides the story of this ancient have operated at different times. because 235 U decays much fas- anthropology, epidemiology, human noroviruses have reveal- natural nuclear reactor. Meshik and The other involved the role of ter than 238 U, in the past, 235 U gerontology, health economics ed many similarities in gene se- his colleagues inferred from the water acting as a neutron moder- was more abundant. and policy, journalism, public quence, structure and overall xenon analysis the mode of opera- ator. As the temperature of the "For example, 2 billion years health, library science, biosta- arrangement of the genome. tion and also the method of safely reactor went up, water was con- ago, 235 U was five times higher, tistics, business, medicine, psy- But Virgin acknowledged that storing nuclear wastes, particularly verted to steam, reducing the about 3 percent, approximately chiatry, psychology, law, bio- differences between mouse and fission xenon and krypton. neutron thermalisation and shut- the concentration of enriched ethics and sociology. human physiology may signifi- "This is very impressive, to ting down the chain reaction. The uranium used in modern com- "From the perspective of cantiy alter MNV-l's interactions think this natural system not only chain reaction re-started only mercial reactors." the school, the launch of this with its host. went critical, but it also safely when the reactor cooled down Another vital condition for new center is exciting not only For example, mice do not ap- stored the waste," Meshik said. and the water increased again. self-sustaining nuclear reaction is for the advanced mental pear to be able to vomit. Addi- "Nature is much smarter than we Analysis of the xenon, the the high content of a moderator health services research that tionally, researchers aren't sure are. Nature is the first genius. largest concentration of xenon to slow the neutrons, Meshik said. will be produced, but also for yet whether MNV-1 can make "We have all kinds of problems ever found in any natural materi- Water, carbon, most organic com- the outreach to social-services mice with normal immune sys- with modern-day nuclear reactors. al, confirmed the water method. pounds, silicon dioxide, calcium agencies to improve the quali- tems sick. This reactor is so independent, It also revealed the role of alu- oxide and magnesium oxide are ty of services delivered," said "The bottom line is that this with no electronics, no models. mophosphate as the system's all natural neutron moderators. Edward F. Lawlor, Ph.D., dean mouse model provides us with a Just using the fact that water waste absorber. Also, the concentrations of of the School of Social Work very useful way to examine cer- boiled at the reactor site might Xenon is extremely rare on neutron absorbents — iron, and the William E. Gordon tain similar aspects of the noro- give contemporary nuclear reactor Earth and very characteristic of potassium, beryllium and espe- Professor. viruses," Virgin said. "Among researchers ideas on how to oper- the fission process. Chemically cially gadolinium, samarium, For more information other things, we'll be using it to ate more safely and efficiendy." inert, the element has nine iso- europium, cadmium and boron about the center or the open look at how the capsid protein In 1952, Paul Kuroda predicted topes and is abundant in many — should be low. house, call the center at enables infection, viral replica- that if the right conditions existed, nuclear processes. "Only when all of these re- 935-5687 or go online to tion processes and the receptors a natural nuclear reactor system "You get a big diagnostic fin- quirements are met can a self- gwbweb.wusd.edu/users/ on host cells that enable the virus could go critical. Twenty years gerprint with xenon, and it's easy sustaining chain reaction occur," cmhsr. to infect specific cell types." later, noticing that uranium ore to purify," said Hohenberg, who Meshik said. record.wustl.edu WASHINGTON UNIVERSITY IN ST. LOUIS Dec. 10,2004 7 Notables Zwerling Wrighton honored by YWCA BY ANDY CLENDENNEN they miss as students away from home. Risa Zwerling Wrighton was She spends most evenings at honored at the YWCA's annu- Harbison House, where she co- al Leader Lunch and inducted hosts dinners honoring distin- into the Academy of Leaders at the guished faculty and visiting digni- 24th annual event Dec. 9 at the taries, as well as events with stu- Millennium Hotel in St. Louis. dents, civic groups and WUSTL Each year, the YWCA Leader supporters. Lunch event honors 10 or more "There were times in my life, outstanding professional women for when I was working and raising the important role they play in bus- my two daughters as a single par- iness, politics, education, science ent, when all I could do was try to and technology, the arts, professions keep our own lives going," she and racial justice. said. "Later, after I remarried and Along with honoring "special my children were older, it was December degrees Philip Needleman, Ph.D., University trustee and science partner for leaders" from St. Louis, the YWCA great to discover that I had the Prospect Ventures, delivers an address during the December Degree Candidate Recognition selects a "future leader" (a senior psychological energy, experience Ceremony Dec. 5 in Graham Chapel. A reception for the more than 130 degree candidates who from a local high school) and a and opportunity to make a bigger attended the ceremony, along with their families and friends, and faculty and administrators, fol- "racial justice" honoree. difference in this world — to help lowed in Mallinckrodt Student Center. Needleman chaired the School of Medicine's Department of "I was thrilled to learn that I others beyond my own family. Pharmacology from 1976-1989 and was senior executive vice president, chief scientific officer and chairman of research and development at Pharmacia Corp. (formerly Monsanto/Searle) from 1989- received the award, especially be- "That is a wonderful place to 2003. In addition to Needleman's address, Mark S. Wrighton gave the Chancellor's Message to the be in life — when you can see cause I was nominated by the senior degree candidates. management of (Magellan Health beyond your own need." Services)," said Zwerling Wrighton, wife of University Chancellor Mark S. Wrighton. "It was rewarding to know that my co-workers recog- nized that I not only worked hard Obituaries for the company, but also was involved in the community." At Magellan, the largest pro- vider of employee assistance pro- Van Duyn, 83; poet laureate, former instructor in English grams and managed behavioral health services in the country, BY SUSAN KIIXENBERG MCGINN 1967. She later served as poetry Zwerling Wrighton manages a consultant for the Olin Library group responsible for acquisition, Mona Van Duyn, a former in- Modern Literature Collection and development and implementation structor in the Department of as the Visiting Hurst Professor of of programs to assist employers in English in Arts 8c Sciences, a Pu- English in 1987. from POSTCARDS FROM CAPE SPLIT maintaining the well-being and litzer Prize-winner and the na- She also taught poetry work- productivity of their work forces. tion's first female poet laureate, shops as a visiting professor in the A strong believer in a keeping died Wednesday, Dec. 1,2004, of English department's master of Why am I dazzled? It is only anotherharvest. work and life balanced, Zwerling bone cancer at her home in fine arts Writing Program in 1983 The world blooms and we all bend and bring Wrighton shares the same commit- University City, Mo. She was 83. and 1985. ment on behalf of students at Van Duyn, who started wri- Van Duyn produced nine vol- from ground and sea and mind its handsome harvests. Washington University. She created ting poetry at age 5, earned a umes of poetry, including To See, the Home Plate program, which bachelor's degree from Northern To Take (1970), for which she won pairs freshmen with local families Iowa University in 1942 and a the National Book Award for Po- - Mona Van Duyn to help recapture the experiences master's from the University of etry in 1971. Iowa in 1943. She served as poet laureate That same year, she married from 1992-93. In April 1991, she Poet Laureate of the United States 1992-^93 Jarvis Thurston, Ph.D., now pro- won the Pulitzer Prize in poetry Teacher and Literary Editor Washington University Mark Smith fessor emeritus for her seventh book, Near Chan- and former ges (1990). named director chair of the "Mona wrote about what she WUSTL English knew — which were mostly every- A plaque in recognition of Mona Van Duyn was hung, by coinci- of Career Center department. day things and not-so-everyday dence, on Dec. 1, the day she died. The plaque hangs outside In 1947, she books — and then put her Duncker Hall, home of the Department of English, next to one hon- BY NEIL SCHOENHERR and Thurston thoughts down as simply and oring the University's other U.S. poet laureate, Howard Nemerov. founded Per- plainly as possible, considering the Mark W Smith, J.D., has been spective: A Quar- intricacies of her rhyme schemes were made of two parts salt water was someone to sit with. And had named director of The Career terly of Litera- and stanza forms," said William H. and one part vinegar," Gass con- a hand to hold." Center, announced James E. Mc- Van Duyn ture while they Gass, Ph.D., the David May Dis- tinued. "Her poems were wise The Academy of American Leod, vice chancellor for students were teaching at tinguished University Professor because she didn't pretend. She Poets named her a fellow in and dean of the College of Arts & the University of Louisville. Emeritus in the Humanities. "Yet made sure her bitterness was 1980 and one of its 12 chancellors Sciences. When Thurston joined the the calm lines didn't add up to the beautiful. She made sure bad in 1985. Smith, currently the associate WUSTL English faculty in 1950, ordinary. Strange things happened things could go out in a good A member of the American dean for students in the School of the magazine moved with them to in them: 'We slapped the smirking dress. Good things she saw Academy and Institute of Arts Law, will begin his new position St. Louis. Van Duyn and Thurston mother and the swollen father and through like sonar through seas. and Letters, she was elected to the Jan. 1. produced it from St. Louis until it went to live in museums and "After breaking our knuckles American Academy of Arts and "I am very excited about this ceased publication in 1975. anthologies.' digging in bleak rock, she said Sciences in 1996. new opportunity," Smith said. "I Van Duyn lectured in English "Her tears, which she could 'some of us sat and waited with The funeral service was have met with most of the people in University College from 1950- unashamedly shed in her poems, whatever was in the world.' She private. in The Career Center and am very impressed with everyone there. "It is very clear to me that the University has made The Career Center a focus point. I look for- Townsend, 82; professor emeritus in physics, alum ward to the challenge." At the law school, Smith BY SUSAN KIIXENBERG MCGINN him as "an electronics wizard." and chair of physics, and Nor- Behrens; and a grandson, Michael taught legal research and writing, According to Norberg, Town- berg, with Arts 8c Sciences' Sam- Robert Behrens. business law and pre-trial proce- Jonathan (Jack) Townsend, send designed electronic instru- uel I. Weissman, Ph.D., professor The interment was private. dure courses. Ph.D., professor emeritus of mentation to meet other people's emeritus of chemistry, and Barry Before joining the University physics in Arts & Sciences and a research needs around campus, Commoner, Ph.D., former profes- he was an attorney at the interna- University alumnus, died Monday, not just in physics. sor of biology, drew heavily on tional law firm of Bryan Cave in Nov. 29,2004. He was 82. "He took a very individualistic Townsend's skills. Virgil Loeb memorial St. Louis. He practiced primarily Townsend earned a bachelor's approach to designing electron- "What he really loved was in the labor and employment degree in physics in 1943 from ics," Norberg said. "He was a very making things work," Norberg scheduled for Dec. 11 area, with an emphasis on federal the University of Denver and a hard worker and a valued associ- said. court litigation. Smith also has master's in 1948 and a doctorate ate. He is often credited in gradu- "He was the guy who made A memorial service for Virgil extensive experience with general in physics in 1951, both from ate students' and other faculty's things work — electronic devices, Loeb Jr., M.D., will be at corporate mergers and acquisi- WUSTL. His doctoral dissertation papers for his contributions to mechanical devices. He built the 11 a.m. Dec. 11 in Graham Cha- tions and estate planning. was on positron studies. their research." apparatus not only for research pel. Loeb, professor emeritus of In 1999, Missouri Gov. Mel He was named an assistant He played a major role in the but also for teaching purposes." clinical medicine, died Tuesday, Carnahan appointed Smith to the professor in 1951 and promoted design of electronic instrumenta- After retiring, Townsend con- Oct. 26, 2004. He was 83. St. Louis Board of Police Com- to associate professor in 1957. tion for the University's early nu- tinued to work with students in Loeb was a hematologist and missioners, where he served as He retired as professor emeritus clear magnetic resonance (NMR) the freshman laboratory. medical oncologist and former president. in 1987. and electron spin resonance He was preceded in death national president of the Ameri- Smith earned an undergradu- Richard E. Norberg, Ph.D., pro- (ESR) research in the 1950s. by his wife, Patricia Bassford can Cancer Society. He also was a ate degree from Harvard Univer- fessor of physics in Arts & Sci- Interdepartmental research on Townsend. founding member of the commu- sity in 1982 and a law degree from ences, who knew Townsend for NMR and ESR between George E. Among the survivors are a nity advisory board for the Site- WUSTLin 1986. more than 50 years, referred to Pake, Ph.D., a former professor daughter, Victoria Townsend man Cancer Center. 8 RECORD WASHINGTON UNIVERSITY IN ST. LOUIS Dec. 10,2004 Washington People

For Barton H. Hamilton, Ph.D., it's all about the questions. It's the quest for answers that drives Hamilton, the Robert Brookings Smith Distingu- ished Professor of Entrepreneur- ship in the Olin School of Busi- ness, to teach, research and mentor. A professor of economics, management and entrepreneur- ship at the Olin School since 1996, Hamilton jams his time between classes with researching, mentor- ing students and junior faculty, and taking care of his 11-month- old twins, Bogdan and Nina. "I love doing research. I come to work every day challenged," Hamilton says. "This is the best job in the world. Really, you come to work every day and you have some question that you're trying to answer or some set of questions you're trying to answer, and you're around a bunch of smart people that all have similar quests that they're on. "I've never said, 'Gosh, I wish I was doing something else,'" he Barton H. Hamilton, Ph.D., talks business with students Nicole Brown (left) and Erica Greenberg. adds. "I've never seen another job Kenneth A. Harrington, managing director of the Skandalaris Center for Entrepreneurial Studies, says I'd rather do." Hamilton "is a great colleague and one of the reasons that I enjoy being at Washington University." Teaching and research go hand- enter the Olin Cup, in which her the business of medicine. There's team placed as a semifinalist. just a lot of interesting business "Bart is an academic, but he still and economic questions there, Seeing it through to completion has a good understanding of the and they're real important." real business world, and he enjoys He and co-researcher Brian P. in-hand, Hamilton says. His paternal grandfather was working with startups," Coulter McManus, Ph.D., are working on Barton Hamilton "I think what makes a universi- an early aviation pioneer who later says. "And he thinks like an entre- a long-term research project ty great — and certainly what I sold his aircraft business to what preneur. I think that's a rare quali- about infertility treatments that think is a strength of the Olin became Hamilton Sunstrand. ty, and especially in an academic." will ultimately result in several delights in School of Business — is we have Hamilton's maternal grandfather Clifford Holekamp's second- papers. really high-caliber research. We're had a catering business that ca- prize Olin Cup-winner in 2000, Their research studies the helping students research-focused, and that's part of tered the building of the Hoover Foot Healers, led to Holekamp's effect that lack of insurance cover- the reason I wanted to come here Dam and the burgeoning movie inclusion in the St. Louis Business age for such procedures has on and why I like it here so much." business in the 1930s. Journal's 2003 "30 Under 30" list of access to care, quality of care and make business Hamilton came to the Olin That gold rush-like period be- movers and shakers. outcomes; what role competition School from McGill University, the tween the two world wars offered "Professor Hamilton was in- plays; and what role the govern- ideas reality leading English-language institu- many opportunities for people in strumental in starting my busi- ment should play. tion in Montreal, where he taught California. ness," says Holekamp, who incor- "Those are all very interesting economics and conducted eco- "What's interesting to me about porated his podiatry/foot-care questions," Hamilton says. nomic research for five years. entrepreneurship is some people business the day of his M.B.A. They expect the research to When a referendum for secession were able to take advantage of that Class of 2000 graduation. Hamil- gain understanding not only of of the Quebec province from and be successful," Hamilton says. ton nominated him for a Kupke infertility treatments, but also Canada failed by a slim margin, "It's kind of like what we had in Entrepreneurship Award, which more-general lessons about med- Hamilton decided it was time to ical markets, says McManus, an leave before the issue arose again. assistant professor of economics "I figured I didn't want to be in at the Olin School since fall 2001. a place that didn't value some of "Bart has a very good sense of its institutions," he says. "Bart is an academic, but he still has a good which microeconomic issues are Besides, the Canadian chill was important and might yield fruitful a bit of a shock to the Santa Bar- understanding of the real business world research opportunities, says Mc- bara, Calif., native. Hamilton ma- and he enjoys working with startups. And he Manus. "He has a great ability to jored in economics at the Univer- use data and statistical methods to sity of California, Berkeley, after thinks like an entrepreneur. I think that's a present a coherent and strong writing in his entrance-exam essay rare quality, and especially in an academic." analysis of economic issues." that he wanted to be an economics On the personal side, "Bart is a BY EILEEN P. DUGGAN professor. LORI COULTER very warm and generous guy," "How a 16-year-old ever got McManus says. "He has done a lot the idea that he wanted to be an to welcome me — and other jun- economics professor, I have no the '90s with the Internet bubble." came with $5,000. The idea Hole- ior faculty — to Olin." idea," Hamilton says. He suspects As a professor of entrepreneur- kamp developed with Hamilton Kenneth A. Harrington, man- his interest in statistics and econo- ship, Hamilton guides undergradu- in the Hatchery course was rated aging director of the Skandalaris metrics — applying statistical ate and master of business admin- by Inc. Magazine in 2003 as one of Center for Entrepreneurial Studies tools to economic data — grew istration students through their the top five ideas to watch, Hole- and a senior lecturer in entrepre- out of his childhood passion for business plans as part of the Hatch- kamp says. neurship, says Hamilton has "a baseball statistics. ery entrepreneurship class and now "I think (Hamilton) really unique combination of teaching, After graduating from Berkeley the Olin Cup competition. embodies what the Olin ideal is research and interpersonal skills. in 1985, Hamilton went straight "There's nothing more exciting supposed to be," Holekamp says. He is a great colleague and one of into a graduate program at Stan- than seeing somebody pick a "He's great for providing an intel- the reasons that I enjoy being at ford University, from which he dream and, through a little bit of lectual give-and-take, and there's Washington University." earned a doctorate in economics interacting with them in and out- something beyond the intellectual Outside of work, Hamilton in 1993. side the classroom, forming that in that he really cares. He wants and his wife, Ursula, are big St. In addition to a preoccupation idea into something they're actual- you to be a success in life as well Louis Rams fans and enjoy going with RBIs and ERAs, Hamilton ly going to start," Hamilton says. as in business." to games and training camp — at gained a youthful admiration for "And what's exciting is seeing peo- As exciting as it is to watch stu- least, they did before the twins his grandfathers, both successful ple actually take the plunge and dents succeed, Hamilton has never were born. entrepreneurs. start the business. It's risky. considered starting his own busi- But he hasn't given up his life- "Your friends who have their ness. He's more than content to long offbeat hobby of keeping pet M.B.A.s and other WashU under- teach undergrads and graduate stu- reptiles, including several red-foot graduate degrees are going out dents, as well as executives enrolled tortoises that live in the family's working for consulting firms or in the Olin School's executive edu- back yard during the summer. investment banks, and you're cation programs. "Some people like to go fish- starting a swimsuit business or a "Teaching executives is a lot of ing," he says. "I like to go lizard- podiatry business." fun because they really challenge catching." Former Hamilton student Lori you to make what you're talking Coulter says, "Bart recognized my about real-world relevant," he says. Barton H. Hamilton passion for entrepreneurship early "Also it forces you into thinking and helped to develop my critical about problems in a different way Title: Robert Brookings Smith Dis- thinking skills." on the research side." tinguished Professor of Entrepre- Her Lori Coulter TrueMeasure In his research, Hamilton has neurship swimwear company was hatched studied many facets of economics, Family: Wife, Ursula Kopij; twins, in the 2003 Olin Cup competition. especially labor and health-care Bogdan and Nina During coursework for her 1999 economics. "It's a big part of the economy," Education: Bachelor's degree in eco- M.B.A., Coulter worked with nomics, University of California, Hamilton on a business plan for a Hamilton says. "We've been in an era over the past 15 years when Berkeley, 1985; doctorate in econom- Bart Hamilton and his wife, Ursula Kopij, enjoy Thanksgiving Day previous startup idea. Hamilton ics, Stanford University, 1993 with their twins, Bogdan (right) and Nina. later encouraged her to return to there's been a transformation of