JOURNAL OF VIROLOGY Volume 63 May 1989 No. 5

ANIMAL Proper Processing of Dengue Nonstructural NS1 Requires the N-Terminal Hydrophobic Signal Sequence and the Downstream Nonstruc- tural NS2a. B. Falgout, R. Chanock, and C.-J. Lai ...... 1852-1860 Transcriptionally Active Immediate- of Pseudorabies Virus Binds to Specific Sites on Class II Promoters. Wanda A. Cromlish, Susan M. Abmayr, Jerry L. Workman, Masami Horikoshi, and Robert G. Roeder ... 1869-1876 Short, Duplicated Sequence Indicative of the Recombinogenicity of the Junction between a Unique and an Inverted Repeat Sequence in the S Component of the Virus Type 1 . Kenichi Umene ...... 1877-1883 Control of mRNA Stability by the Virion Host Shutoff Function of . Asha A. Oroskar and G. Sullivan Read ...... 1897-1906 Molecular Analysis of the Function of Direct Repeats and a Polypurine Tract for Plus-Strand DNA Priming in Woodchuck Hepatitis Virus. Christoph Seeger and Johnna Maragos ...... 1907-1915 A Neutrophil-Derived Antiviral Protein: Induction Requirements and Biological Properties. H. Bielefeldt Ohmann, M. Campos, D. R. Fitzpatrick, N. Rapin, and L. A. Babiuk ...... 1916-1923 Detection of Virus-Specific RNA-Dependent RNA Polymerase Activity in Extracts from Cells Infected with Lymphocytic Choriomeningitis Virus: In Vitro Syn- thesis of Full-Length Viral RNA Species. Frances V. Fuller-Pace and Peter J. Southern...... 1938-1944 Initiation of Replication of the Human Hepatitis Delta Virus Genome from Cloned DNA: Role of Delta Antigen. Mark Y.-P. Kuo, Mei Chao, and John Taylor ...... 1945-1950 Modified Model for the Switch from Sendai Virus Transcription to Replication. Silvia Vidal and Daniel Kolakofsky ...... 1951-1958 Regulation of Human Immunodeficiency Virus Expression by the Gene Product. Marie-Louise Hammarskjold, Jessica Heimer, Bjorn Hammarskjold, Indu Sangwan, Laura Albert, and David Rekosh ...... 1959-1966 The Proteolytic Cleavage of PE2 to Envelope Glycoprotein E2 Is Not Strictly Required for the Maturation of Sindbis Virus. John F. Presley and Dennis T. Brown ...... 1975-1980 Identification of a Neutralizing Epitope on Glycoprotein gp58 of Human Cytomegalovirus. U. Utz, W. Britt, L. Vugler, and M. Mach ...... 1995-2001 Identification, Sequence, and Transcriptional Mapping of the Major Pro- tein Gene of the Baculovirus Autographa californica Nuclear Polyhedrosis Virus. Suzanne M. Thiem and Lois K. Miller ...... 2008-2018 The 1A Protein of Respiratory Syncytial Virus Is an Integral Present as Multiple, Structurally Distinct Species. Robert A. Olmsted and Peter L. Collins...... 2019-2029 Intramolecular Homologous Recombination in Cells Infected with Temperature- Sensitive Mutants of Virus. Michael Merchlinsky ...... 2030-2035

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Herpes Simplex Virus Type 2 Mutants with Deletions in the Intergenic Region between ICP4 and ICP22/47: Identification of Nonessential cis-Acting Ele- ments in the Context of the Viral Genome. Colton A. Smith, Michael E. Marchetti, Paul Edmonson, and Priscilla A. Schaffer...... 2036-2047 Molecular Biology of . VIII. Quantitative Analysis of Regulation of during Virus Replication. Moira A. Johnson and Malcolm A. McCrae ...... 2048-2055 C Virus Esterase: Analysis of Catalytic Site, Inhibition, and Possible Function. Reinhard Vlasak, Thomas Muster, Andrea M. Lauro, James C. Powers, and Peter Palese ...... 2056-2062 High Nucleotide Substitution Error Frequencies in Clonal Pools of Vesicular Stomatitis Virus. David A. Steinhauer, Juan Carlos de la Torre, and John J. Holland...... 2063-2071 Extreme Heterogeneity in Populations of Vesicular Stomatitis Virus. David A. Steinhauer, Juan Carlos de la Torre, Eva Meier, and John J. Holland...... 2072-2080 Mutational Analysis of Polyomavirus Small-T-Antigen Functions in Productive Infection and in Transformation. Ingrid Martens, Stefan V. Nilsson, Stig Linder, and Goran Magnusson ...... 2126-2133 Analysis of Neutralizing Antigenic Sites on the Surface of Type A12 Foot-and- Mouth Disease Virus. B. Baxt, V. Vakharia, D. M. Moore, A. J. Franke, and D. 0. Morgan ...... 2143-2151 Synthesis, Cellular Location, and Immunogenicity of Bovine Herpesvirus 1 Glyco- gI and glll Expressed by Recombinant Vaccinia Virus. Sylvia van Drunen Littel-van den Hurk, Tim Zamb, and Lorne A. Babiuk ...... 2159-2168 Physical Mapping and Nucleotide Sequence of a Herpes Simplex Virus Type 1 Gene Required for Capsid Assembly. B. Pertuiset, M. Boccara, J. Cebrian, N. Berthelot, S. Chousterman, F. Puvion-Dutilleul, J. Sisman, and P. Sheldrick...... 2169-2179 Purification and Characterization of Adult Diarrhea : Identification of Viral Structural Proteins. Zhao-Yin Fang, Roger 1. Glass, Maria Penaranda, Hong Dong, Stephan S. Monroe, Leying Wen, Mary K. Estes, Joseph Eiden, Robert H. Yolken, Linda Saif, Vera Gouvea, and Tao Hung 2191-2197 The Sendai Virus Nucleocapsid Exists in at Least Four Different Helical States. E. H. Egelman, S.-S. Wu, M. Amrein, A. Portner, and G. Murti...... 2233-2243 The Cellular 68,000-Mr Protein Kinase Is Highly Autophosphorylated and Acti- vated Yet Significantly Degraded during Poliovirus Infection: Implications for Translational Regulation. Tracy L. Black, Brian Safer, Ara Hovanessian, and Michael G. Katze...... 2244-2251 Construction and Characterization of a Herpes Simplex Virus Type 1 Mutant Un- able To Transinduce Immediate-Early Gene Expression. Chris 1. Ace, Tom A. McKee, J. Michael Ryan, Janet M. Cameron, and Chris M. Preston.... 2260-2269 Nuclear Subcompartmentalization of Simian Virus 40 Large T Antigen: Evidence for In Vivo Regulation of Biochemical Activities. Reinhold Schirmbeck and Wolfgang Deppert...... 2308-2316 Fine Mapping of Antigenic Site II of Herpes Simplex Virus Glycoprotein D. Vicki J. Isola, Roselyn J. Eisenberg, Gary R. Siebert, Conrad J. Heilman, Wesley C. Wilcox, and Gary H. Cohen ...... 2325-2334 Limited Temperature-Sensitive Transactivation by Mutant Adenovirus Type 2 Ela Proteins. M. L. Fahnestock and James B. Lewis...... 2348-2351

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Alterations in the Structure of New and Old Forms of Simian Virus 40 Large T Antigen (T) Defined by Age-Dependent Epitope Changes: New T Is the Same as ATPase-Active T. Lois C. Tack, Jocelyn H. Wright, and Elizabeth G. Gurney ...... 2352-2356 Differences in Replication of Attenuated and Neurovirulent Polioviruses in Human Neuroblastoma Cell Line SH-SY5Y. Nicola La Monica and Vincent R. Racaniello...... 2357-2360 Unmyristylated Moloney Murine Virus Pr659'9 Is Excluded from Virus Assembly and Maturation Events. Alan M. Schultz and Alan Rein ...... 2370-2373 Formation of Infectious Hybrid Virions with Gibbon Ape Leukemia Virus and Human T-Cell Leukemia Virus Retroviral Envelope and the gag and Proteins of Moloney . Carolyn Wilson, Marvin S. Reitz, Hiroto Okayama, and Maribeth V. Eiden...... 2374-2378 Nucleotide Sequence and Distinctive Characteristics of the env Gene of Endoge- nous Feline Leukemia Provirus. D. Vinod Kumar, Brian T. Berry, and Pradip Roy-Burman ...... 2379-2384 Evidence for the Role of the P2 Protein of Human Rhinovirus in Its Host Range Change. Nancy B. Lomax and Fay H. Yin ...... 2396-2399 Translation of gag, pro, and pol Gene Products of Human T-Cell Leukemia Virus Type 2. Nurith Mador, Amos Panet, and Alik Honigman ...... 2400-2404

VIRUS-CELL INTERACTIONS The Herpes Simplex Virus Immediate-Early Protein, ICP4, Is Required To Poten- tiate Replication of Human Immunodeficiency Virus in CD4+ . Mary A. Albrecht, Neal A. DeLuca, Randal A. Byrn, Priscilla A. Schaffer, and Scott M. Hammer...... 1861-1868 Novel Use of Polymerase Chain Reaction To Amplify Cellular DNA Adjacent to an Integrated Provirus. Jonathan Silver and Vijaya Keerikatte ...... 1924-1928 Regulation of Cellular Transduced by Herpes Simplex Virus. Barbara Panning and James R. Smiley ...... 1929-1937 Human Liver Plasma Membranes Contain Receptors for the Hepatitis Pre-Sl Region and, via Polymerized Human Serum Albumin, for the Pre-S2 Region. Patrizia Pontisso, Marie-Anne Petit, Matthew J. Bankowski, and Mark E. Peeples ...... 1981-1988 Conformational Change in the Floor of the Human Rhinovirus Canyon Blocks Adsorption to HeLa Cell Receptors. Daniel C. Pevear, Marilyn J. Fancher, Peter J. Felock, Michael G. Rossmann, Matthew S. Miller, Guy Diana, Adi M. Treasurywala, Mark A. McKinlay, and Frank J. Dutko ...... 2002-2007 Pattern of Expression of Ecotropic Murine Leukemia Virus in Gonads of Inocu- lated SWR/J Mice. Jean-Jacques Panthier, Pierre Gounon, Hubert Condamine, and Frangois Jacob ...... 2134-2142 Transformation of Human Cells by Oncogenic Viruses Supports Permissiveness for Parvovirus H-1 Propagation. Steffen Faisst, Jorg R. Schlehofer, and Harald zur Hausen ...... 2152-2158 JC Virus-Simian Virus 40 Containing Heterologous Regulatory Signals and Chimeric Early Regions: Identification of Regions Restricting Transfor- mation by JC Virus. Sheryl Haggerty, Duard L. Walker, and Richard J. Frisque ...... 2180-2190 Loss of Bovine Papillomavirus DNA Replication Control in Growth-Arrested Transformed Cells. Stanley Burnett, Udo Kiessling, and Ulf Pettersson 2215-2225 Continued on following page Continued from preceding page

Release of Simian Virus 40 Virions from Epithelial Cells Is Polarized and Occurs without Cell Lysis. Edward T. Clayson, Lorraine V. Jones Brando, and Richard W. Compans...... 2278-2288 Isolation and Characterization of a Viable Adenovirus Mutant Defective in Nu- clear Transport of the DNA-Binding Protein. Vaughn Cleghon, Karl Voelkerding, Nathalie Morin, Claude Delsert, and Daniel F. Klessig ...... 2289-2299 Molecular Localization of Abortive Infection of Resident Peritoneal Macrophages by Herpes Simplex Virus Type 1. Page S. Morahan, Saifuddin Mama, Farvardin Anaraki, and Kathryn Leary...... 2300-2307 Two Blocks in Moloney Murine Leukemia Virus Expression in Undifferentiated F9 Embryonal Carcinoma Cells as Determined by Transient Expression Assays. Gerold Feuer, Makoto Taketo, Ronnie C. Hanecak, and Hung Fan...... 2317-2324 Association of p60VYf with Middle in - Transformed Cells. Ivan D. Horak, Toshiaki Kawakami, Francoise Gregory, Keith C. Robbins, and Joseph B. Bolen ...... 2343-2347 Stimulation of Estrogen Receptor mRNA Levels in MCF-7 Cells by Herpes Simplex Virus Infection. Elizabeth A. Offord, Robin E. Leake, and Joan C. M. Macnab...... 2388-2391 Investigation of Varicella-Zoster Virus Infection of Lymphocytes by In Situ Hybridization. Celine M. Koropchak, Suzanne M. Solem, Pamela S. Diaz, and Ann M. Arvin...... 2392-2395 Translational Readthrough of the Murine Leukemia Virus gag Gene Amber Codon Does Not Require Virus-Induced Alteration of tRNA. Ya-Xiong Feng, Dolph L. Hatfield, Alan Rein, and Judith G. Levin ...... 2405-2410

VIRAL AND CELLULAR Multiple Steps Are Required for the Induction of Tumors by Abelson Murine Leukemia Virus. Patrick L. Green, Donal A. Kaehler, L. Michelle Bennett, and Rex Risser...... 1989-1994 Distinct Helper Virus Requirements for Abelson Murine Leukemia Virus-Induced Pre-B- and T-Cell Lymphomas. Yves Poirier and Paul Jolicoeur...... 2088-2098 Structure, Origin, and Transforming Activity of Feline Leukemia Virus-myc Recombinant Provirus FTT. David L. Doggett, Anne L. Drake, Vanessa Hirsch, Mary E. Rowe, Virginia Stallard, and James 1. Mullins ...... 2108-2117 Lymphotropic Papovavirus Early Region Is Specifically Regulated in Transgenic Mice and Efficiently Induces Neoplasia. Jiandong Chen, Kathy Neilson, and Terry Van Dyke ...... 2204-2214 Avian Erythroblastosis Virus Transforms a Novel Mast Cell-Basophil Precursor Target in the Japanese Quail. M. Giovannella Moscovici, Michael L. Siegel, and Carlo Moscovici...... 2335-2339 Mutational Analysis of Bovine Papillomavirus E6 Gene. Karen H. Vousden, Elliot J. Androphy, John T. Schiller, and Douglas R. Lowy ...... 2340-2342 The Mlvi-J Locus Involved in the Induction of Rat T-Cell Lymphomas and the pvt-JlMis-J Locus Are Identical. Charles F. Koehne, Pedro A. Lazo, Kenneth Alves, Jung S. Lee, Philip N. Tsichlis, and Paul V. O'Donnell ... 2366-2369 Susceptibility to raf and raflmyc Is Governed by Different Genetic Loci. S. Peter Klinken, Janet W. Hartley, Torgny N. Fredrickson, Ulf R. Rapp, and Herbert C. Morse III...... 2411-2414

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PLANT VIRUSES Variability and Evolution of the Plant RNA Virus Pepper Mild Mottle Virus. Emilio Rodriguez-Cerezo, Andres Moya, and Fernando Garcia-Arenal..... 2198-2203

VIRAL PATHOGENESIS AND IMMUNITY Polymorphism of Cytotoxic T- Clones That Recognize a Defined Nine- Amino-Acid Immunodominant Domain of Lymphocytic Choriomeningitis Virus Glycoprotein. Etienne Joly, Maria Salvato, J. Lindsay Whitton, and Michael B. A. Oldstone...... 1845-1851 Mapping of Attenuating Sequences of an Avirulent Poliovirus Type 2 Strain. Eric G. Moss, Robert E. O'Neill, and Vincent R. Racaniello ...... 1884-1890 The Visna Virus Long Terminal Repeat Directs Expression of a Reporter Gene in Activated Macrophages, Lymphocytes, and the Central Nervous Systems of Transgenic Mice. Judy A. Small, Charles Bieberich, Zahra Ghotbi, Jay Hess, George A. Scangos, and Janice E. Clements ...... 1891-1896 Epstein-Barr Virus Gene Expression in Malignant Lymphomas Induced by Experimental Virus Infection of Cottontop Tamarins. L. S. Young, S. Finerty, L. Brooks, F. Scullion, A. B. Rickinson, and A. J. Morgan ...... 1967-1974 Survival of Athymic (nulnu) Mice after Theiler's Murine Encephalomyelitis Virus Infection by Passive Administration of Neutralizing Monoclonal . Robert S. Fujinami, Alexander Rosenthal, Peter W. Lampert, Andreas Zurbriggen, and Masahito Yamada...... 2081-2087 Transcriptional Activation of Bovine Leukemia Virus in Blood Cells from Experi- mentally Infected, Asymptomatic Sheep with Latent Infections. Donna M. Lagarias and Kathryn Radke...... 2099-2107 Evidence for a Role of Virulent Human Immunodeficiency Virus (HIV) Variants in the Pathogenesis of Acquired Immunodeficiency Syndrome: Studies on Sequential HIV Isolates. Matthijs Tersmette, Rob A. Gruters, Frank de Wolf, Ruud E. Y. de Goede, Joep M. A. Lange, Peter T. A. Schellekens, Jaap Goudsmit, Han G. Huisman, and Frank Miedema...... 2118-2125 Protease Characterized as a Dimeric Aspartic Proteinase. lyoko Katoh, Yoji Ikawa, and Yoshiyuki Yoshinaka...... 2226-2232 Molecular Mechanism of Complex Infection by Bacteria and Virus Analyzed by a Model Using Serratial Protease and Influenza Virus in Mice. Takaaki Akaike, Akhteruzzaman Molla, Masayuki Ando, Shukuro Araki; and Hiroshi Maeda...... 2252-2259 Human Immunodeficiency Virus-Specific Cytotoxic Responses of Seropositive Individuals: Distinct Types of Effector Cells Mediate Killing of Targets Expressing gag and env Proteins. Yves Riviere, Frangoise Tanneau- Salvadori, Armelle Regnault, Olga Lopez, Philippe Sansonetti, Bruno Guy, Marie-Paule Kieny, Jean-Jacques Fournel, and Luc Montagnier...... 2270-2277 Cell-to-Cell Transmission of Human Immunodeficiency Virus Type 1 in the Presence of Azidothymidine and Neutralizing Antibody. Phalguni Gupta, Raghavan Balachandran, Monto Ho, Amy Enrico, and Charles Rinaldo.... 2361-2365 Resistance to Foot-and-Mouth Disease Virus Mediated by trans-Acting Cellular Products. Juan Carlos de la Torre, Susana de la Luna, Juana Diez, and Esteban Domingo...... 2385-2387 Date of Issue: 13 April 1989