Europaisches Patentamt J) European Patent Office © Publication number: 0 371 509 A3 Office europeen des brevets

EUROPEAN PATENT APPLICATION

© Application number: 89122134.3 © int. ci.s: C07G 11/00, C12P 1/06, C12N 1/20, A61K 35/66, @ Date of filing: 30.11.89 //C12P1:06,C12R1:465, C12N1:20,C12R1 :465

© Priority: 01.12.88 IT 2280888 Inventor: Cassani, Giorgio 93, Via Roma © Date of publication of application: 1-20010 Arluno (IT) 06.06.90 Bulletin 90/23 Inventor: Crestani, Enrico 15, Via Falcone © Designated Contracting States: 1-28100 (IT) AT BE CH DE ES FR GB LI NL SE Inventor: Spera, Silvia 62, Via Fiume © Date of deferred publication of the search report: 1-21020 (IT) 13.03.91 Bulletin 91/11 Inventor: Garavaglia, Carlo 7, P.zza Vittoria 1-20012 Cuggiono Milan(IT) © Applicant: PRESIDENZA DEL CONSIGLIO DEI Inventor: Pirali, Giorgio MINISTRI -UFFICIO DEL MINISTRO PER IL 32, Via Volonterio COORDINAMENTO DELLE lNIZIATIVE PER LA 1-21047 Saronno Varese(IT) RICERCA SCIENTIFICA E Inventor: Confalonieri, Giovanni TECNOLOGICA 76, Lungotevere Thaon di 15, Via Caronni Revel I-20052 Monza Milan(IT) 1-00100 Roma(IT)

© Inventor: Cidaria, Dante © Representative: Weinhold, Peter, Dr. et al 4, via Montesanto Patentanwalte Dr. V. Schmied-Kowarzik 1-28100 Novara(IT) Dipl.-lng. G. Dannenberg Dr. P. Weinhold Dr. Inventor: Andriollo, Nunzio D. Gudel Dipl.-lng. S. Schubert Dr. P. Barz 21, Via Turati Siegfriedstrasse 8 1-20021 Bollate Milan(IT) W-8000 Munchen 40(DE)

© Antibiotics and process for producing them. CO ^ © The AB-021 antibiotics and the main compo- qj nents thereof, AB-021 a antibiotic and AB-021 b anti- O biotic, obtained by means of the controlled aerobic W cultivation of Streptomyces s p. NCIB 40068 in an ^. aqueous nutrient cultivation medium, are disclosed, rs Said antibiotics show a biological activity against pathogenic fungi of agrarian cultivations, pathogenic O human fungi and bacteria.

Xerox Copy Centre European Number Patent Office EUROPEAN SEARCH Application REPORT EP 89 12 2134

DOCUMENTS CONSIDERED TO BE RELEVANT Citation of document with Indication, where appropriate, Relevant CLASSIFICATION OF THE Category of relevant passages to claim APPLICATION (Int. CI.5) C 07 G 11/00 C 12 P 1/06 C 12 N 1/20 A 61 K 35/66 // (C 12 P 1/06 C 12 R 1:465) (C 12 N 1/20 C 12 R 1:465)

TECHNICAL FIELDS SEARCHED (Int. CI.5) C 12 N C 12 P C 12 R A 61 K

The present search report has been drawn up for all claims Place of search Date of completion of search Examiner The Hague 10 December 90 RAJIC M. CATEGORY OF CITED DOCUMENTS E : earlier patent document, but published on, or after X : particularly relevant if taken alone the filing date Y : particularly relevant if combined with another D : document cited in the application document of the same catagory L : document cited for other reasons A: technological background O: non-written disclosure & : member of the same patent family, corresponding P : intermediate document document T : theory or principle underlying the invention