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Saturday December 8, 2018 Saturday December 8, 2018 The 2018 ASCB | EMBO Meeting l ascb-embo2018.ascb.org 25 7:30 am-7:00 pm Registration Open Registration Area 8:30 am-12:30 pm Special Interest Subgroups – Morning A. 5th Biannual Frontiers in Cytokinesis Room 33B B. Building the Cell 2018 Room 30D C. Cell Biology in Cancer Immunity Room 31B D. Evolutionary Cell Biology Room 28D E. Intracellular Cargo Transport by Molecular Motors: What a Mesh! Room 29B F. Mechanisms of DNA Repair in Maintenance of Genome Integrity Room 29C G. Spatial and Temporal Analytical Tools for Cell Atlases Room 28B H. Systems and Synthetic Biology of Decoding Complex Cellular Rhythms Room 33C I. The Many Functions of Cytoskeletal Proteins in the Cell Nucleus Room 31C J. Wnt Signaling in Development and Cancer Room 30B 10:30-11:30 am Getting into Graduate School: The Do’s, the Don’ts, and the What If’s Room 15A 10:30-11:30 am Planning Your Exit from Graduate School Room 15B 11:45 am-12:45 pm Getting the Most out of Your Thesis Committee Room 15A 1:30-5:30 pm Special Interest Subgroups – Afternoon K. Bottom-Up Cell Biology Room 30D L. Cellular Organization of Metabolism: Biology, Structure, Room 33C and Function of Enzyme Polymers M. Cilia and Cell Signaling in Development and Tissue Regeneration Room 29B N. Emerging Model Systems Room 29C O. Machine Learning in Cell Biology Room 31C P. Neuronal Cytoskeleton: A Complex Interplay of Cytoarchitecture Room 30B and Dynamics Q. Next Generation Correlative Microscopy: Biological Applications Room 31B and Emerging Techniques R. The Mechanics and Membrane Dynamics of the Nuclear Envelope Room 33B S. Patterning the Cytoskeleton - PTMs, MAPs, ABPs Room 28D T. The Midbody: From Cytokinesis to Signaling Organelle Room 28B 2:00-3:00 pm Hit the Ground Running: Early Success in Graduate School Room 15A 3:15-5:45 pm Judged Poster Session Room 16A Daily Schedule—Saturday, December 8 6:00 pm Keynote Lecture: Sean Morrison Ballroom 20B Immediately Following Keynote- Opening Night Reception Sails Pavilion 10:00 pm 8:00-9:00 pm International Research and Training Exchange Fair Sails Pavilion 26 The 2018 ASCB | EMBO Meeting l ascb-embo2018.ascb.org Saturday, December 8 SATURDAY OO Special Interest Subgroups – Morning 8:30 am-12:30 pm The following member-organized sessions were selected by the ASCB Program Committee . All meeting attendees are welcome to SATURDAY participate . Meeting registration is required . Subgroup A: 5th Biannual Frontiers in Cytokinesis Room 33B Organizers: Julie C. Canman, Columbia University; Ulrike Eggert, King’s College London; Amy Shaub Maddox, University of North Carolina, Chapel Hill; Douglas Robinson, Johns Hopkins School of Medicine; Dimitrios Vavylonis, Lehigh University; and Jian-Qiu Wu, Ohio State University Cytokinesis is a spectacular cell shape change process that requires coordination of complex cellular machinery over many scales of space and time . Chemical and mechanical signaling pathways integrate the mitotic spindle with the cell cortex to position the division plane and promote assembly of a contractile actomyosin network, leading to remodeling of the plasma membrane and cortex . In a multicellular setting, cytokinesis also integrates cell-cell and cell-substrate communication . This geometrically simplified cell shape change serves as a paradigm for numerous other shape change events, including those that take place during cell migration and tissue morphogenesis . In this meeting, we bring together a group of investigators who use systematic genetic and chemical methods, biophysical techniques, high resolution imaging, diverse model systems, and mathematical modeling . Presentations: 8:30 am Introduction . Organizers 8:35 am Control of cytokinesis by Plk1 in C . elegans . Sebastian Gomez-Cavazos, Oegema Lab, Ludwig Institute for Cancer Research 8:50 am Spindle to cortex communication in frog egg . Christine Field, Harvard University 9:10 am Actions ta microtubule plus ends in the phragmoplast for cytokinesis . Bo Liu, University of California, Davis 9:30 am Assembly and structure of the fission yeast cytokinetic ring . Kathy Gould, Vanderbilt University 9:50 am A theory to predict the contraction rate of random cytoskeleton network . François Nedelec, EMBL 10:10 am Work and dissipation in the cell cytoskeleton . Michael Murrell, Yale University 10:30 am Break 10:45 am The role of membrane shape in modulating cytokinetic furrow ingression . Jian Liu, National Institute of Heart, Lung, and Blood 11:05 am Flagella set the stage for myosin-independent cytokinesis in Giardia . Alex Paredez, University of Washington, Seattle 11:25 am Cleavage furrow formation without F-actin in Chlamydomonas . Masayuki Onishi, Pringle Lab, Stanford University 11:40 am Actin xidoreductiono as a novel component of the NoCut/abscission checkpoint . Jian Bai, Echard Lab, Institut Pasteur 11:55 am The role of calcium in Rho-dependent remodeling of epithelial tight junctions . Sara Varadarajan, Miller Lab, University of Michigan 12:10 pm Asymmetric division, stem cell size heterogeneities and cell fate . Agathe Chaigne, Paluch Lab, MRC Laboratory for Molecular Cell Biology . University College London, UK 12:25 pm Final remarks . Organizers The 2018 ASCB | EMBO Meeting l ascb-embo2018.ascb.org 27 Subgroup B: Building the Cell 2018 Room 30D Organizer: Susanne Rafelski, Allen Institute for Cell Science, Seattle WA Modern cell biology has made great strides in understanding cell structure and function . As with any engineering problem, however, there is a third important aspect that needs to be understood besides structure and function, and that is assembly . How are the complex three-dimensional structures found within the cell specified by a one-dimensional genome? In this session we will explore the mechanisms by which cellular structures are determined and regulated . Because this question lies at the interface of biology and physics, this Building the Cell session will be highly interdisciplinary with speakers whose interests range from physics and mathematical modeling to biochemistry and cell biology . Presentations: 8:30 am Introduction . Susanne Rafelski, Allen Institute for Cell Science 8:40 am Creating a stem cell state landscape: integrated cellular reorganization during differentiation and division of the human iPS cell . Susanne Rafelski, Allen Institute for Cell Science 9:00 am Building artificial membranes . Neal Devaraj, UC San Diego 9:20 am Understanding the heterotypic mitochondrial outer membrane fusion machine . Suzanne Hoppins, University of Washington 9:40 am The morphology space of yeast mitochondrial networks . Greyson Lewis, Wallace Marshall Lab, UC San Francisco 10:00 am Harnessing motors, flows, and fluctuations for intracellular transport . Elena Koslover, UC San Diego 10:20 am Break 10:40 am A fundamental trade-off between information flow in single cells and cellular populations . Eric J. Deeds, University of Kansas 11:00 am Dynamic architecture of the microtubule cytoskeleton . Marija Zanic, Vanderbilt University 11:20 am Super-resolution imaging of chromatin organization . Melike Lakadamyali, University of Pennsylvania 11:40 am Spreading of epigenetic silencing and activation in single cells . Lacramioara Bintu, Stanford University 12:00 pm Design principles for self-organized cell polarity . Ed Munro, University of Chicago Subgroup C: Cell Biology in Cancer Immunity Room 31B Organizers: Xiaolei Su, Yale University; and Enfu Hui, University of California, San Diego Cancer immunotherapy aims to activate or release the inhibition of immune cells for the sake of killing tumors . A variety of signaling molecules or immune effectors, including cell surface receptors, antibodies, and cytokines, have been targeted or engineered for eliminating cancer cells . Despite the clinical success in various immunotherapies, including checkpoint blockade and CAR-T, the cellular mechanism underlying how immune cells respond in those therapies remains unclear . This session will focus on recent progress in understanding and manipulating signaling events, transcriptional program, and reorganization of cellular structures that mediate immune cells’ responses to cancer antigens . It will not only advance our knowledge in understanding the molecular mechanism underlying cancer immunity but also provide insights in designing new strategies for cancer therapy . Presentations: 8:30 am Introduction . Xiaolei Su, Yale University, and Enfu Hui, University of California, San Diego 8:35 am Phase Separation in Chimeric Antigen Receptor (CAR) Signaling . Xiaolei Su, Yale University 8:55 am Engineering Next-Generation T Cells for Cancer Immunotherapy . Yvonne Chen, University of California, Los Angeles 9:15 am Engineering the Next-Generation of Immune Cell Therapies for Cancer . Kole Roybal, University of California, San Francisco 9:35 am TCR Catch Bonds with Antigenic pMHC Activate T Cell Signaling and Its Implication for Effective Immunotherapy . Wei Chen, Zhejiang University 9:55 am Mechanopotentiation at the Cytotoxic Immunological Synapse . Morgan Huse, Memorial Sloan- Kettering Cancer Center 10:15 am Break 10:30 am Self-Cancellation of the PD-L1/PD-1 Pathway . Enfu Hui, University of California, San Diego 28 The 2018 ASCB | EMBO Meeting l ascb-embo2018.ascb.org 10:50 am Understanding T Cell Inhibition and Costimulation to Improve Cancer Immunotherapy . Alice Kamphorst, Icahn School of Medicine at Mount Sinai 11:10 am Integration of Signals for Activation and Inhibition of NK Cells . Eric Long, National Institute of SATURDAY
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