WesBanco,WesBanco, Inc.Inc. 2020 AnnualAnnual ReportReport

1870Years 2020 FINANCIAL HIGHLIGHTS (in thousands, except shares and per share amounts) December 31, 2020 2019 % Change FOR THE YEAR Earnings per common share—diluted $ 1.77 $ 2.83 (37.5) Earnings per common share—diluted, excluding certain items (1)(2) $ 1.88 $ 3.06 (38.6) Dividends declared per common share $ 1.28 $ 1.24 3.2 Net income available to common shareholders $ 119,400 $ 158,873 (24.8) Net income available to common shareholders, excluding certain items (1)(2) $ 127,083 $ 171,827 (26.0) Average common shares outstanding—diluted 67,310,584 56,214,364 19.7 Period end common shares outstanding 67,254,706 67,824,428 (0.8) Period end preferred shares outstanding 150,000 — 100.0

AT YEAR END Securities $ 2,722,069 $ 3,257,654 (16.4) Net portfolio loans 10,603,406 10,215,556 3.8 Total assets 16,425,610 15,720,112 4.5 Deposits 12,429,373 11,004,006 13.0 Total FHLB and other borrowings 790,953 1,697,977 (53.4) Subordinated and junior subordinated debt 192,291 199,869 (3.8) Shareholders’ equity 2,756,737 2,593,921 6.3

TRUST ASSETS AT MARKET VALUE (3) $ 5,025,565 $ 4,719,966 6.5

KEY RATIOS Return on average assets 0.73% 1.24% (41.1) Return on average assets, excluding certain items (1)(2) 0.77 1.34 (42.5) Return on average tangible assets (1) 0.85 1.40 (39.3) Return on average tangible assets, excluding certain items (1)(2) 0.90 1.51 (40.4) Return on average equity 4.50 7.49 (39.9) Return on average equity, excluding certain items (1)(2) 4.79 8.11 (40.9) Return on average tangible equity (1) 8.61 14.01 (38.5) Return on average tangible equity, excluding certain items (1)(2) 9.12 15.10 (39.6) Return on average tangible common equity (1) 8.94 14.01 (36.2) Return on average tangible common equity, excluding certain items (1)(2) 9.47 15.10 (37.3) Average loans to average deposits 91.66 88.59 3.5 Allowance for loan losses to total loans 1.72 0.51 237.3 Allowance for loan losses to total non-performing loans 455.38 104.14 337.3 Non-performing assets to total assets 0.25 0.35 (28.6) Net loan charge-offs to average loans 0.06 0.09 (33.3) Dividend payout ratio 72.32 43.82 65.0 Dividend payout ratio, excluding certain items (1)(2) 68.09 40.52 68.0 Non-interest income as a percentage of total revenues 21.10 22.59 (6.6) Efficiency ratio (1)(4) 56.38 56.68 (0.5) Net interest margin (4) 3.37 3.62 (6.9)

CAPITAL RATIOS AT YEAR END Shareholders’ equity to total assets 16.78% 16.50% 1.7 Tangible equity to tangible assets (1) 10.52 10.02 5.0 Tangible common equity to tangible assets (1) 9.58 10.02 (4.4) Tier 1 leverage ratio 10.51 11.30 (7.0) Tier 1 capital to risk-weighted assets 14.72 12.89 14.2 Total capital to risk-weighted assets 17.58 15.12 16.3 Common equity tier 1 capital ratio 13.40 12.89 4.0

PER COMMON SHARE Closing common stock price $ 29.96 $ 37.79 (20.7) Book value at year end 38.84 38.24 1.6 Tangible book value at year end (1) 21.75 21.55 0.9 (1) See non-GAAP financial measures for additional information relating to the calculation of this ratio. (2) Certain items excluded from the calculation consist of after-tax restructuring and merger-related expenses. (3) These assets are held by Wesbanco in fiduciary or agency capacities for its customers and therefore are not included as assets on Wesbanco’s Consolidated Balance Sheets. (4) Taxable-equivalent basis. TO OUR SHAREHOLDERS: In addition to being our 150th anniversary, 2020 was another successful year for WesBanco. From a financial standpoint, solid execution of our well-defined strategies allowed us to generate record annual pre-tax, pre-provision earnings, while remaining a well-capitalized financial institution with solid liquidity and a strong balance sheet. But, most importantly, the year was successful when measured from a community action standpoint. During 2020, we directly assisted nearly 15,000 individuals, families, businesses, and non-profit organizations as they navigated through the pandemic. We are extremely proud of how our employees have responded