MODUS ED SWT Low Intensity Focus Model Shockwave Therapy System TABLE of CONTENTS

MODUS ED SWT Low Intensity Focus Model Shockwave Therapy System TABLE OF CONTENTS

What Is Shockwave Therapy? Average Success Rate

Shockwave therapy is a multi-purpose treat- 20% before treatment 80% after treatment system used in orthopedics, physio- ment... 09 Advantages and Performance... therapy, sports medicine, urology, aesthetics, 21 beauty and veterinary medicine... How Erectile Dysfuntion Treat- MODUS ED SWT ment Applied? The Modus EDSWT system, unlike the radial shockwave therapy system, provides targeting Shock waves are applied to 5 different points of the penis.... 22 and focusing to a selected anatomical region... 10 Erectile Dysfunction Treat- What Is Erectile Dysfunction ment In 6 Steps (Ed)? 1. Apply Ultrasonic Gel Erectile Dysfunction, known as impotence, is 2. On The Left Side 1 Area, Proximal Pe- the inability to initiate or continue the hard- 11 nile Shaft (The Root Of The Penis) Apply 22 ening required for sexual intercourse... Shock Waves... ABOUT US Why Modus ED SWT? Who’s at risk from erectile dysfunction? In the treatment performed with the focused shockwaves of Modus ED SWT, Alcoholism and other forms of substance 09 pathological factors are eliminated, and abuse and Tobacco use even in severe patients, complete recov- 24 İnceler Medikal Chronic Diseases (High cholesttes)... ery is observed...

İNCELER MEDİKAL Co. Ltd. was estab- tem, and Spark, extracorporeal shock- What Is Erectile MODUS ED SWT Areas Of Dysfunction (Ed)? Usage lished in 2010, in Ankara. The company wave lithotripsy system, were put on the Erectile Dysfunction, known as impotence, is Erectile Dysfunction started its activities by providing sales market by İnceler Medikal. the inability to initiate or continue the hard- 11 Plantar Fasciitis ening required for sexual intercourse... Achilles Tendinopathy Bone Tissue – Bone Pathologies and after sales support on ESWL-ESWT The devices produced by İnceler Medikal Osgood Schlatter What Is Peyronie’s Disease Calcified Tendonitis Of The Shoulder Shockwave Systems for all health insti- are designed to combine high security, (Penile Curvature)? Lateral Epicondylopathy Myofascial Syndrome 29 tutions in Turkey with its expert staff. advanced technology, economic and The hardening of the male sexual organ Trigger Points – Idiopathic Low Back occurs by filling the sinusoids in the tis- Broken Bone sues called Corpus Cavernosum located Skin Ulcers Over time, İnceler Medikal has reached aesthetic parameters. The company in the structure of the penis.... Carpal Tunnel Syndrome Shockwave (Modus Ed Swt) Therapy For 13 Veterinary Medicine the capacity and level of expertise to aims to continue its presence in the sec- Peyronie’s Disease Other Areas of Usage... Application For Peyronie’s Disease ... produce spare parts compatible for tor as an R&D company. İnceler Medikal Technical Specifications What Is Prostatitis? many world-famous brands. It started to has gained the customers’ trust MEMORY /10-user defined The prostate, located in the lower part Treatment Protocol... 38 project its own products in 2012. with its experienced staff and quality of the bladder and in the anterior part of the rectum, is an extremely important Various Researches service understanding. organ for the urinary system... What Are The Types Of Prostatitis? Wang and his colleagues, known for their What Is The Relation Between Prostatitis work in the field of ED SWT, have explored The first product, Lithobox, pneumatic And Erectile Dysfunction? ED SWT treatment and have discovered... Shockwave (Modus Ed Swt) Treatment 16 40 lithotripsy system, followed by Modus, For Prostatitis... Reference extracorporeal shockwave therapy sys- Low-Intensity Shockwave Gutersohn A., Caspari G., Vopahl M., Erbel R. (1999) Upregulation of VEGF Therapy mRNA in HUVEC via shock Waves... 40 In low-intensity shockwave therapy, shockwaves are applied to an anatomical region, causing mechanical stress 18 and micro trauma... inceler medikal İNCELER MEDİKAL İNCELER MEDİKAL

Diabetic Foot Ulcers Myofascial Syndrome

AREAS OF USAGE Carpal Tunnel Syndrome Broken Bone

Erectile Dysfunction, Peyronie (Penile Curvature) Avascular necrosis (AVN) Lymphedema

Prostate Plantar Fasciitis Dermato Sclerosis Veterinary Medicine

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Modus ed swt İNCELER MEDİKAL İNCELER MEDİKAL

WHAT IS SHOCKWAVE THERAPY? Shockwave therapy is a multi-purpose cal intervention in the sessions. treatment system used in orthopedics, When shockwaves are applied to an physiotherapy, sports medicine, urolo- anatomical area, it causes mechanical gy, aesthetics, beauty and veterinary stress and micro trauma, and this trau- medicine. It’s an effective treatment ma leads to the formation of angio- method used for accelerating recov- genic factors. Thus, it induces a series ery and eliminating the indications of biological reactions that increase that cause acute and/or chronic pain blood flow and trigger neovasculari- without the need for invasive oper- zation of tissue. ations and medications. Shockwave therapy system has no side effects. It does not require medication or surgi- Modus ed swt

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WHAT IS ERECTILE DYSFUNCTION (ED)? Erectile Dysfunction, known as impotence, is the inability to initiate or continue the hardening required for sexual intercourse.

Who’s at risk from erectile dysfunction?

MODUS ED SWT Alcoholism and other forms of sub- Sedentary Lifestyle & Obesity stance abuse and Tobacco use Low Intensity Focus Model Shockwave Therapy System

The Modus EDSWT system, unlike some parts of the body with shock- the radial shockwave therapy sys- wave therapy. New blood vessels are tem, provides targeting and focus- formed after neovascularization. As ing to a selected anatomical region. a result of penile blood supply that It provides direct transmission of increases with the formation of new shockwaves to the focal point. In vessels, the body’s natural erection addition to physiotherapy, ortho- system returns to its normal state pedics, veterinary areas, Modus again. EDSWT is also used in the treatment of erectile dysfunction known as impotence. Modus ED SWT has a working principle based on Electrohydraulic focusing. It uses acoustic waves to initiate the neovascularization process in Modus ed swt

Chronic Diseases (High cholesterol, High blood pressure, Diabetes)

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WHAT CAUSES ERECTILE DYSFUNCTION?

The hardening of the male sexual or- from the central nervous system dur- gan occurs by filling the sinusoids in ing sexual intercourse help more blood the tissues called Corpus Cavernosum flow to these sinusoids. located in the structure of the penis. Cardiovascular Diseases Treatments for prostate cancer or en- Arteries that relax with the signals larged prostate & Surgeries or injuries that affect the pelvic area or spinal cord Corpus Cavernosum

Adults aged 40 years and older Psychological Problems

The pressure increase caused by blood adjusting the blood flow in the penis. filling in the penile tissues stimulates Any physical discomfort that prevents the Tunica albuginea region, which is this blood filling causes the penis not vital for the continuity of erection. The to be erect or to maintain the hard- activated region ensures that the erec- ness. tion state is maintained by constantly

Modus ED SWT®(Focused - Shockwave Therapy)

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WHAT IS PEYRONIE’S DISEASE (PENILE CURVATURE)?

It is a disease that causes deform- Peyronie’s disease is that one of the ity in the penis with the formation of two spongy tissues that make the pe- hard plaques on the penis. Peyronie’s nis erect does not develop and the disease is a change in the structure penis is curved to this non-developing of the sheath called tunica albuginea side. Penile curvature that occurs later surrounding the penile tubes (Corpus is usually seen in individuals over the Cavernosum) and the formation of age of 50. Peyronie’s disease occurs Before Peyronie’s Disease During Peyronie’s hard plaques that cause deformities in due to the formation of calcification Treatment Disease Treatment the penis. Lesions in the penis general- between the spongy tissue that makes ly occur on the upper part of the penis. the penis harden and the sheath sur- The disease is most common between rounding this tissue. Peyronie’s disease APPLICATION FOR the ages of 40-60. is more common in diabetics, smokers Penile curvature can be congenital or and alcohol abusers, and those with may occur later because of various hypertension. PEYRONIE’S DISEASE reasons. The basis of the congenital Modus ED SWT therapy applies low-in- cedure, patients continue their lives tensity shock waves to the shaft and where they left off. Anesthesia and crus area on the penis with a non-in- hospitalization are not required. It is vasive method. As a result, it helps applied at least 1 or 2 sessions a week. SHOCKWAVE (MODUS to increase blood flow in these areas Depending on agedness and size of of the penis and so for the treatment the plaque, 6-24 sessions are required. ED SWT) THERAPY FOR of Peyronie’s disease. After the pro- Each session takes 30-40 minutes. PEYRONIE’S DISEASE

In patients treated with Modus ED remarkable effects of the treatment SWT, pain relief and improvement in on the pain during erection and pe- erectile dysfunction were found. The nile curvature contribute to the sexual applied low-intensity shockwaves ac- lives of patients suffering from Peyro- tivate the tissue healing mechanism in nie’s disease with a quality erection, Peyronie’s plaque in the acute phase besides the treatment of pain and cur- and cause the plaque to shrink. These vature in the penis.

After Peyronie’s Disease Treatment

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tis. In other words, the fact that men prostatitis treatment may experience who have prostatitis problems can erection problems with the effect of WHAT IS also have erection problems. In addi- hormones. In surgeries for prostate tion, it is a known fact that hormone cancer, nerves belonging to erection PROSTATITIS? therapies used for inflammation in are usually cleared from the area. As prostate cancer cases affect testoster- a result, serious erection problems oc- The prostate, located in the lower part ment is necessary for some types. In one. As a result, a person undergoing cur in the patient. of the bladder and in the anterior part prostate problems that require treat- of the rectum, is an extremely impor- ment, medication is provided to re- tant organ for the urinary system. Pros- move the inflammation from the body SHOCKWAVE (MODUS ED tatitis, also known as prostate inflam- in a short time. mation, refers to the inflammation that Prostatitis is a problem that is most- SWT) TREATMENT FOR occurs in the prostate gland. This sit- ly seen in men under the age of 50. uation causes problems for men many In men over the age of 50, this situa- PROSTATITIS times and causes a feeling of pain. It is tion shows itself as an enlarged pros- a problem that is quite simple to treat. tate. The last stage of this problem is Scientific studies have shown that: - By affecting nerve impulses, shock- Prostate inflammation usually occurs prostate cancer. Prostatitis takes place - By providing new vein formation, wave therapy diminishes pain and uri- in more than one way. Although some among the main health problems ex- - By increasing the blood supply, nary complaints and improves sexual types of prostate problems can be perienced by almost every man, de- - By preventing inflammation, functions by 80%. overcome without treatment, treat- pending on age. - By reducing muscle contractions, WHAT ARE THE APPLICATION FOR TYPES OF PROSTATITIS? PROSTATITIS

Prostate can be examined in four main Prostatitis and Asymptomatic Inflam- Modus ED SWT treatment is applied are not required. At least 6-12 sessions types. These four types are Chronic matory Prostatitis. Among these four to the area called the perineum (be- are applied twice a week. The treat- Prostatitis/Chronic Pelvic Pain Syn- types, chronic pelvic pain syndrome tween the eggs and the anus) and on ment takes approximately 20 minutes. drome (CP/CPPS), Chronic Bacterial stands out the most. skin. Anesthesia and hospitalization Prostatitis, Acute (Sudden) Bacterial WHAT IS THE RELATION BETWEEN PROSTATITIS AND ERECTILE DYSFUNCTION?

As a result of scientific research, it has the same reason. Accordingly, inflam- been concluded that prostatitis and mations that cause erection problems erection problems may be caused by in the body can also lead to prostati-

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LOW-INTENSITY SHOCKWAVE THERAPY

In low-intensity shockwave therapy, formation of angiogenic factors. Thus, shockwaves are applied to an anatom- it induces a series of biological reac- ical region, causing mechanical stress tions that increase blood flow and and micro trauma. This mechanical trigger neovascularization of tissue. stress and micro trauma lead to the

INCREASE IN VESSEL NUMBER (DURING TREATMENT)

LESS VESSEL / LESS BLOOD MORE VESSEL / MUCH BLOOD (BEFORE TREATMENT) (AFTER TREATMENT)

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AVERAGE SUCCESS RATE %20 before treatment

%80 after treatment ADVANTAGES AND PERFORMANCE

During treatment, medication, prosthesis, etc. are not used. This method of treatment is completely non-invasive.

After Modus ED SWT treatment, patients no longer need medical treatment which they have previously undergone.

Modus ED SWT treatment success is over 80%. The success rate exceeds 60% in severe patients who do not even respond to medication

Unlike other treatment methods, it does not need to be used before every sexual intercourse. It does not require medication such as anesthesia or sedatives during and after the procedure. After the procedure, the patient continues his/her daily life.

It has been observed that Modus ED SWT treatment increases the blood vessels and penis size.

Modus ED SWT therapy offers a permanent treatment by completely removing the occlusion in the vessels and accelerating the Modus ED SWT®(Focused - Shockwave Therapy) formation of new blood vessels.

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3. ON the RIGHT SIDE, 1 AREA HOW ERECTILE DYSFUNTION PROXIMAL PENILE SHAFT (the root of penis) APPLY SHOCK TREATMENT APPLIED? WAVES

Shock waves are applied to 5 different specific areas a total of 1,500 shots are points of the penis. Shock shots are ap- applied. The treatment lasts 6 sessions plied on the objects that provide erec- in total. Depending on the severity of tion in the penis. It is tried not to be the discomfort, treatment can be com- applied to the points where the nerves pleted in 6-12 sessions. Each session pass. The important thing is applying takes approximately 20 minutes. Se- 4. ON the LEFT SIDE 2 AREA, shock waves to the area called the Cor- dation, sedative, etc. before treatment pus Cavernosum (each of the erectile are not needed. There is no side effect MIDDLE PENILE SHAFT (body tissue mass filling with blood on both such as pain, aches, swelling, bruising, area of the penis) APPLY sides of the penis). The more vasculari- burning and irritation during or after SHOCK WAVES zation and blood supply are increased, the procedure. After the procedure, the more successful the treatment will the patient continues his daily life. be. In a session, 300 shocks for each ERECTILE DYSFUNCTION

TREATMENT IN 6 STEPS 5. ON the RIGHT SIDE 2 AREA, MIDDLE PENILE SHAFT (body 1. APPLY ULTRASONIC GEL area of the penis) APPLY SHOCK WAVES

6. ON THE RIGHT SIDE 3 AREA, DISTAL PENILE SHAFT 2. ON the LEFT SIDE 1 AREA, (distal areas of the penis) AP- PROXIMAL PENILE SHAFT PLY SHOCK WAVES (the root of the penis) APPLY SHOCK WAVES

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WHY MODUS ED SWT? Modus ED SWT® Handpiece

In the treatment performed with the focused shockwaves of Modus ED SWT, pathological factors are eliminated, and even in severe patients, complete recov- ery is observed.

With Modus ED SWT, vessel width is not increased as in other treatment methods, new vein formation is provided. Thus, the risky side effects, which are likely to be seen especially in people with cardiovascular diseases, are avoided.

Since Modus ED SWT is a non-invasive treatment method, the patient is not treated surgically. The patient continues his daily life from where he left off after the sessions lasting about 20 minutes.

The Modus ED SWT system is a device specially designed for penile applica- tions in this area. The Modus ED SWT system is designed to provide maximum efficiency even from the lowest rhythms of shockwaves. Unlike other devices on the market, the number of shocks can be individually adjusted for each person Modus ED SWT® Applicators in this system, which has adjustable electro frequencies. Thus, Modus ED SWT treatments give much more effective results in a short time.

Modus ED SWT offers 3 applicator options for treatment.

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MODUS ED SWT AREAS OF USAGE

Erectile Dysfunction

Erectile Dysfunction, known as impotence; is defined as the inability of achieving or maintaining an erection. Modus ED SWT treatment is applied directly to various parts of the penis and the root of the penis. 300 shots in one session and a total of 1,500 shots are delivered to each applied area. It is applied to 5 different points on the penis. Vascular erectile dysfunction is permanently treated after Modus ED SWT treatment.

Plantar Fasciitis

The structure called plantar fascia is the flat strip of tissue that connects the heel bone to the toes. The plantar fascia runs from front to back along the sole of the foot and attaches to the heel. This structure, which supports the foot arch, also helps walking. The connective tissue strip surrounding the sole of the foot can be torn or dam- aged due to the foot being exposed to excessive pressure. Accordingly, it causes pain in the heel and hardening in the heel. With focused shockwave therapy, the negative effects on the feet are eliminated.

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Achilles Tendinopathy Calcified Tendonitis Of The Shoulder

The Achilles tendon is one of the Calcific tendonitis (or tendonitis) oc- longest tendons in the body, extend- curs when calcium builds up in your mus- ing from the calf to the bones in the cles or tendons. Although this can occur heel. It is a flexible tissue in the form anywhere on the body, it usually occurs of a strip. It is located on the heel and in the rotator cuff. The rotator cuff is a behind the ankle. Tendons gain mobil- group of muscles and tendons that con- ity more quickly, successfully and per- nect the upper arm to the shoulder. Cal- manently than desired with Modus ED cium buildup in this area can cause pain SWT shockwave therapy. and discomfort as well as restricting range of motion in the arm. In mild-mod- erate situations ESWT (extracorporeal shock wave therapy) can be used. This preventive treatment method is based on the principle of delivering mechanical shock waves to the shoulder. Thus, the pain is eliminated by the creation of free radicals and the change of the biochem- Bone Tissue – Bone Pathologies / istry. Osgood Schlatter Lateral Epicondylopathy Osgood-Schlatter disease is an inflammation of the area just below the It is known as tennis elbow. It is a knee where the tibia of the tendon painful condition seen at the attach- (patellar tendon) in the patella is at- ment site of the muscle tendon to the tached. ESWT (extracorporeal shock- bone on the outside of the elbow. The wave therapy) method can be used elbow joint is located between the for the treatment of Osgood-Schlat- bone called the humerus in the upper ter disease. The duration of sessions part of the arm and the ulna at the of Modus ED SWT in soft tissues is lower part of the arm. In lateral epi- approximately 5-20 minutes. Pain condylitis, there is degeneration and and complaints are largely eliminated weakening of the tendon attachment within 4-6 weeks after a total of 4-5 site. This can cause pain related to sessions with 3-5 days intervals. movements in which the muscle is ac- tive (stretching, grasping, etc.). With Modus ED SWT, it is treated without the need for anesthesia.

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Myofascial Syndrome Broken Bone

Myofascial pain syndrome, defined Patients show symptoms such as as regional musculoskeletal pain, is a pain, cyanosis, swelling, deformity, im- disease that occurs due to acute or paired symmetry, inability to move, chronic trauma of skeletal muscles. In and limitation of movement due to myofascial pain syndrome, there are post-traumatic fractures, dislocations severe pain that constantly recurs. It and sprains in joints, bones and adja- causes complaints such as neck, back, cent tissues. ESWT has an effect on waist pain, pain in the knees, elbows, fracture healing, bone and cartilage bones, pain and stinging in the chest. tissues. It has been observed that in With the superior focusing power non-healing fractures (pseudoartosis), of the Modus ED SWT device, dam- when shock waves are applied around aged tissues are stimulated, and their the fracture, osteoblastic (bone-form- healthy form is achieved. ing cell) activity increases and the per- iosteum (bone membrane) is stimulated and healing is accelerated. Modus ED SWT transmits the shock waves directly to the focal point. Trigger Points – Idiopathic Low Back Diabetic Foot Ulcers

Trigger point is a painful muscle area Diabetic foot ulcers (DFUs) are where the sensitivity in the area where among the most common foot disor- the normal functional relationship of ders with ulceration, infection, and gan- the muscle fibers is disrupted shows grene that may ultimately lead to low- a regional distribution. Trigger points er extremity amputation. The goals of affect the muscle by making it weak treatment include the control of diabe- and tense. It causes strong spasms in tes and proper shoe wear. An effective the muscle group in which they are. It therapy and appropriate foot care are causes especially shoulder, arm and important in wound healing in DFUs. waist pain. The muscles that are in a Recently, extracorporeal shockwave constant state of contraction also put therapy (ESWT) was reported to sig- pressure on the bones, causing these nificantly promote and accelerate the symptoms to appear in the neighbor- healing of complex soft tissue wounds ing joints and disrupt the blood cir- as compared to the standard methods culation of the neighboring area. The of treatment in DFUs. ESWT showed person enters the pain process due to positive results in short-term and long- the decrease in the oxygen in the cir- term outcomes in diabetic patients suf- culation and the nutrients needed by fering from foot ulcers. the metabolism and the accumulation of metabolic wastes.

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Carpal Tunnel Syndrome Other Areas of Usage

Carpal tunnel syndrome is a common Greater Trochanteric Pain Syndrome condition that causes pain, numbness, and tingling in the hand and arm. Car- Approved Standard İndications pal tunnel syndrome is caused by pressure on the median nerve as it travels ESWT For Burns through the carpal tunnel. Studies ESWT For Keloids show that women and older people are more likely to develop the condi- Skin & ESWT tion. It is known that conditions such as heredity, repetitive hand use, preg- ESWT For Loose Skin And Cellullite nancy, diabetes, rheumatoid arthritis, and thyroid gland imbalance trigger Pilot Trial: Hypertrophic Scars carpal tunnel syndrome. First Human ESWT Application On The Open Heart Dring Bypass Surgery

Dermato Sclerosis

Lymphedema

It can also be used in larger areas. Veterinary Medicine

Shock wave therapy is applied to horses and small animals (especially dogs) as applied to humans. Shock waves show antibacterial and anti-in- flammatory effects in the body. It also improves vascular, bone and connective tissue. These biological factors formed by radial shock waves are of great importance in veterinary ap- plications and horse physiotherapy.

Dermato Sclerosis Lymphedema

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DRUG-FREE PAINLESS TREATMENT

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Technical Specifications

WORKINGWORKING PRINCIPLEPRINCIPLE HANDPIECEHANDPIECE HANDPIECEHANDPIECE MEMORYMEMORY PROBEPROBE HEADS HEADSWEIGHTWEIGHT ElectrohydraulicsElectrohydraulics Electrode Life:Electrode 50K-70K Life: 50K-70K 10-user deﬁned10-user deﬁned 3 Units 3 Units 35 kg 35 kg Coil CapacityCoil 2 Capacity million 2 million Focused ORFocused OR shock shock TreatmentTreatment Protocol Protocol ElectromagneticElectromagnetic Focused Focused Shock appliedShock in eachapplied in each Session: 1500Session: shock 1500 shock

Patient Treatment:Patient Treatment: 6 6 sessions= 9Ksessions= shock 9K shock

1 Electrode:1 Electrode:Approx. 6-7 Approx. 6-7 patient patient

FOCUSFOCUS POWERPOWER PENETRATIONPENETRATION SUPPLYSUPPLY DISPLAYDISPLAY DIMENSIONDIMENSION POWERPOWER DEPTHDEPTH FREQUENCYFREQUENCY 220-240 VAC220-240 VAC TFT TouchTFT Screen Touch Screen (W-L-H) 450mm(W-L-H) x 450mm x 1. kademesi1. 0,09mJ/mmkademesi 0,09mJ/mm 0-70mm 0-70mm 1-4 Hz 1-4 Hz 50/60 Hz,50/60 50 W Hz, 50 W 350mm x 350mm930mm x 930mm 2. kademesi2. 0,15mJ/mmkademesi 0,15mJ/mm 3. kademesi3. 0,20mJ/mmkademesi 0,20mJ/mm 4. kademesi4. 0,25mJ/mmkademesi 0,25mJ/mm

OPERATINGOPERATING WARRANTYWARRANTY FUSESFUSES CLASSIFICATIONCLASSIFICATIONINSULATIONINSULATION ENVIRONMENTENVIRONMENTCONDITIONSCONDITIONS

24 Months24 Months 2x1A, 2302x1A, VAC 230 VAC Conforms toConforms EN 60601-1 to EN 60601-1 Internal 12Internal V DC 12 V DC 100 °C ≤ temperature100 °C ≤ temperature ≤ 300 °C ≤ 3000% °C ≤ humidity0% ≤ ≤humidity 95% ≤ 95% Criteria ClassCriteria 1 Type Class B 1 Type B TransformerTransformer Insulation Insulation30% ≤ humidity30% ≤ ≤75% humidity ≤ 75% 500 hPa ≤500 atmospheric hPa ≤ atmospheric P 20 MDD 93/42P 20 MDD CEE 93/42 CEE 700 hPa ≤ atm700 press hPa ≤ 1060atm press hPa ≤ 1060pressure hPa ≤pressure 1060 hPa ≤ 1060 hPa Class IIb Class IIb

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VARIOUS RESEARCHES Wang and his colleagues, known for their work in the field of ED SWT, have explored ED SWT treatment and have discovered that ED SWT has stimulated the expression of growth factors associ- ated with angiogenesis, such as endothelial nitric oxide synthase and vascular endothelial growth factor, and endothelial cell proliferation factors, such as proliferation cell nuclear antigen. They also reported that ED SWT leads to neovascularization and as a result improves blood flow. In addition, there was a significant increase in neovascularization and cell proliferation values with angiogenic levels; they observed that the effect of this increase continued for a long time. The effect of EDSWT on vascular endothelial growth factor (VEGF) levels has also been reported by Gutersohn et al. They observed that ED SWT significantly increased mRNA levels in cells.Studies by Nishida et al. Have shown that VEGF expression of ED SWT is significantly upregulated in ischemic myocardial cells after treatment.

REFERENCE GUTERSOHN A., CASPARI G., VOPAHL M., ERBEL R. (1999) UPREG- ULATION OF VEGF MRNA IN HUVEC VIA SHOCK WAVES. IN PRO- CEEDINGS OF THE INTERNATIONAL CONFERENCE FROM GENES TO THERAPY IN ISCHEMIC AND HEART MUSCLE DISEASE, MAR- BURG, GERMANY, 9–10 OCTOBER ISMST ICC CERTIFICATION COURSE JUNE 21ST, 2017 DONOSTIA/ SAN SEBASTIAN

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PAINLESS AND BEFORE TREATMENT

DRUG AFTER TREATMENT 0.5 cm and FREE above AVERAGE INCREASE THERAPY IN THE PENIS SIZE

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phone: +90 312 255 3346 fax: +90 312 255 3347 e-mail: [email protected] address: İvedik OSB Mah. 1472. Cad. No:120 Yenimahalle Ankara / Türkiye

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