BMJ Open Is Committed to Open Peer Review. As Part of This Commitment We Make the Peer Review History of Every Article We Publish Publicly Available
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BMJ Open: first published as 10.1136/bmjopen-2020-042395 on 13 January 2021. Downloaded from BMJ Open is committed to open peer review. As part of this commitment we make the peer review history of every article we publish publicly available. When an article is published we post the peer reviewers’ comments and the authors’ responses online. We also post the versions of the paper that were used during peer review. These are the versions that the peer review comments apply to. The versions of the paper that follow are the versions that were submitted during the peer review process. They are not the versions of record or the final published versions. They should not be cited or distributed as the published version of this manuscript. BMJ Open is an open access journal and the full, final, typeset and author-corrected version of record of the manuscript is available on our site with no access controls, subscription charges or pay-per-view fees (http://bmjopen.bmj.com). If you have any questions on BMJ Open’s open peer review process please email [email protected] http://bmjopen.bmj.com/ on September 25, 2021 by guest. Protected copyright. BMJ Open BMJ Open: first published as 10.1136/bmjopen-2020-042395 on 13 January 2021. Downloaded from Comparing the cumulative live birth rate of cleavage stage versus blastocyst stage embryo transfers between IVF cycles in women with a good prognosis, a multicentre randomised controlled superiority trial (the ToF trial). ForJournal: peerBMJ Open review only Manuscript ID bmjopen-2020-042395 Article Type: Protocol Date Submitted by the 07-Jul-2020 Author: Complete List of Authors: Cornelisse, Simone; Radboudumc, Obstetrics & Gynaecology Ramos, L.; Radboudumc, Obstetrics & Gynaecology Arends, B.; UMC Utrecht, Department of Reproductive Medicine Brink-van der Vlugt, J.J.; Nij Barrahûs de Bruin, J.P.; Jeroen Bosch Hospital, Department of Obstetrics and Gynecology Curfs, M.H.J.N.; Isala Hospitals, Department of Obstetrics and Gynecology Derhaag, J.; Maastricht University Medical Centre+, Department of Reproductive Medicine van Dongen, A.; Ziekenhuis Gelderse Vallei, Department of Obstetrics and Gynaecology http://bmjopen.bmj.com/ van Echten-Arends, J.; University Medical Centre Groningen, Department of Obstetrics and Gynaecology, Section of Reproductive Medicine Groenewoud, E.R.; Noordwest Ziekenhuisgroep, Department of Obstetrics, Gynaecology and Reproductive Medicine Maas, J.W.M.; Maxima Medical Centre Location Veldhoven, Department of Obstetrics and Gynaecology Pietserse, Q.; Haga Hospital, Department of Obstetrics and Gynaecology van Santbrink, E.J.P.; Reinier de Graaf Groep Slappendel, E.; Nij Geertgen on September 25, 2021 by guest. Protected copyright. Traas, M.; Gelre Ziekenhuizen Apeldoorn, Department of obstetrics and Gynaecology Visser, J.; Amphia Hospital, Department of Obstetrics and Gynaecology Vergouw, C.G.; Amsterdam UMC Locatie VUmc, Department of Reproductive Medicine Verhoeve, H.R.; OLVG Locatie Oost, Department of Obstetrics and Gynaecology van der Westerlaken, L.A.J.; LUMC, Department of Obstetrics and Gynaecology Wurth, Y.; Elisabeth-TweeSteden Ziekenhuis, Department of Reproductive Medicine van der Zanden, M.; Medisch Centrum Haaglanden, Department of Obstetrics and Gynaecology Braat, Didi; Radboudumc, Obstetrics & Gynaecology van Wely, Madelon; Amsterdam University Medical Centres, Centre for Reproductive Medicine Mastenbroek, S.; Amsterdam UMC Locatie AMC, Center for Reproductive For peer review only - http://bmjopen.bmj.com/site/about/guidelines.xhtml Page 1 of 29 BMJ Open BMJ Open: first published as 10.1136/bmjopen-2020-042395 on 13 January 2021. Downloaded from 1 2 3 Medicine, Amsterdam Reproduction & Development research institute 4 Fleischer, K.; Radboud Universiteit, Department of Obstetrics and 5 Gynaecology 6 7 Reproductive medicine < GYNAECOLOGY, Subfertility < GYNAECOLOGY, 8 Keywords: Protocols & guidelines < HEALTH SERVICES ADMINISTRATION & 9 MANAGEMENT 10 11 12 13 14 15 16 For peer review only 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 http://bmjopen.bmj.com/ 34 35 36 37 38 39 40 41 on September 25, 2021 by guest. Protected copyright. 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 For peer review only - http://bmjopen.bmj.com/site/about/guidelines.xhtml BMJ Open Page 2 of 29 1 2 3 BMJ Open: first published as 10.1136/bmjopen-2020-042395 on 13 January 2021. 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Protected copyright. 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 For peer review only - http://bmjopen.bmj.com/site/about/guidelines.xhtml Page 3 of 29 BMJ Open 1 2 3 Title BMJ Open: first published as 10.1136/bmjopen-2020-042395 on 13 January 2021. Downloaded from 4 5 6 Comparing the cumulative live birth rate of cleavage stage versus blastocyst stage embryo 7 transfers between IVF cycles in women with a good prognosis, a multicentre randomised 8 9 controlled superiority trial (the ToF trial). 10 11 12 13 14 S. Cornelisse, L. Ramos, B. Arends, J.(J) Brink-van der Vlugt, J.(P) de Bruin, M.(HJM) Curfs, J. Derhaag, 15 A.(JCM) van Dongen, J. van Echten-Arends, E.(R) Groenewoud, J(WM) Maas, Q. Pieterse, E.(JP)van 16 17 Santbrink, E. Slappendel, M.(AF)Traas, J. Visser, C.(G) Vergouw, H.(R) Verhoeve, L.(AJ) van der 18 Westerlaken, Y. Wurth,For M. van peerder Zanden, M.review van Wely, D.(MM) only Braat, S. Mastenbroek, K. Fleischer. 19 20 21 22 23 Corresponding author 24 Simone Cornelisse, Radboudumc, Department of Obstetrics and Gynaecology, Geert Grooteplein Zuid 25 10, 6525 GA Nijmegen, The Netherlands. 26 Email adress:[email protected] 27 Telephone number: +31 6 41 31 54 59. 28 29 30 31 Co-authors 32 Liliana Ramos, Department of Obstetrics and Gynaecology, Radboud University Medical Centre, 33 Nijmegen, The Netherlands 34 35 Brigitte Arends, Department of Reproductive Medicine, University Medical Centre Utrecht, Utrecht, 36 The Netherlands 37 http://bmjopen.bmj.com/ 38 39 Janneke.J. Brink-van der Vlugt, Fertility Clinic Nij Barrahûs, Wolvega, The Netherlands 40 41 Jan Willem.P. de Bruin, Department of Obstetrics and Gynecology, Jeroen Bosch Hospital, ’s- 42 Hertogenbosch. 43 44 Max.H.J.M. Curfs, Department of Obstetrics and Gynecology, Isala Clinics, Zwolle 45 on September 25, 2021 by guest. Protected copyright. 46 Josien Derhaag, Department of Reproductive Medicine, Maastricht University Medical Centre, 47 48 Maastricht, The Netherlands 49 50 Angelique.J.C.M. van Dongen, Department of Obstetrics and Gynaecology, Hospital Gelderse Vallei, 51 Ede, The Netherlands. 52 53 Jannie van Echten-Arends, Department of Obstetrics and Gynaecology, Section of Reproductive 54 Medicine, University Medical Centre Groningen, University of Groningen, Groningen, The 55 56 Netherlands 57 58 Eva.R. Groenewoud, Department of Obstetrics, Gynaecology and Reproductive Medicine, Noordwest 59 Ziekenhuisgroep, Den Helder, The Netherlands. 60 1 For peer review only - http://bmjopen.bmj.com/site/about/guidelines.xhtml BMJ Open Page 4 of 29 1 2 3 Jacques.W.M. Maas, Department of Obstetrics and Gynaecology, Maxima Medical Centre, BMJ Open: first published as 10.1136/bmjopen-2020-042395 on 13 January 2021. Downloaded from 4 Veldhoven, The Netherlands 5 6 7 Quirine Pieterse, Department of Obstetrics and Gynaecology, Haga Hospital, The Hague, The 8 Netherlands. 9 10 Evert.J.P. van Santbrink, Reinier de Graaf group, Voorburg, The Netherlands 11 12 Els Slappendel, Fertility Clinic Nij Geertgen, Elsendorp, The Netherlands 13 14 Maaike.A.F. Traas, Department of obstetrics and Gynaecology, Gelre Hospital, Apeldoorn, The 15 16 Netherlands 17 18 Jantien Visser, DepartmentFor of Obstetricspeer and review Gynaecology, Amphia only hospital, Breda, The Netherlands 19 20 Harold.R. Verhoeve, Department of Obstetrics and Gynaecology OLVG, Amsterdam, The Netherlands 21 22 Carlijn.G.