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INRC 2019 Program Book-071819 Webivo Contents Pages Contents……………………………………………..……………………………......….1 Executive Committee and Meeting Organizers………………….……………….......2 Welcome……………………………………………..………..……………….…..……..3 General Information…………………………………………....…………………......…4 Events Summary………………………………….………….…………………………..5 INRC 2019 Awardees…………………………….……….……………………...……..7 Program………….………………………………………….…………………………….9 Symposia Abstracts…………………………………………………………………….17 Poster Abstracts…………………………………………………………………...……42 Exhibitor and Sponsor Information……………………………………………..……133 Floor Plan……………………………………………..………….…………….….…...134 Participants………………………………………………………………..…………...135 1 Executive Committee and Meeting Organizers INRC Officers Larry Toll (President, USA) Fred Nyberg (Past-President, Sweden) Lee Yuan Liu-Chen (Treasurer, USA) Amynah Pradhan (Information Officer, USA) INRC Executive Committee Ream Al-Hasani (USA) Meritxell Canals (Australia) Lucia Hipolito (Spain) Emily Jutkiewicz (USA) Eamon Kelly (UK) Minoru Narita (Japan) Stefan Schulz (Germany) Shogo Tokuyama (Japan) James Zadina (USA) INRC 2019 Local Organizing Committee Eduardo Butelman Lakshmi Devi Sandra Comer Lloyd Fricker Mary Jeanne Kreek Brian Reed Larry Toll 2 Welcome 50th International Narcotics Research Conference (INRC) INRC 2019 Program Committee Lakshmi Devi Mary Jeanne Kreek Laura Bohn Eduardo Butelman Meritxell Canals Sandra Comer Lloyd Fricker Lucia Hipolito Susan Ingram Emily Jutkiewicz Minoru Narita Susruta Majumdar Brian Reed Vivianne Tawfik Larry Toll 3 General Information INRC Registration Desk and Message Center will be located at the Grand Hyatt New York, Lobby level (109 East, 42nd Street at Grand Central Terminal) The registration desk hours are: Sunday, July 7, 2019 4:00 PM – 9:00 PM Monday, July 8, 2019 8:00 AM – 6:00 PM Tuesday, July 9, 2019 8:30 AM – 6:00 PM Wednesday, July 10, 2019 8:30 AM – 5:30 PM Thursday, July 11, 2019 8:30 AM – 5:00 PM Pick up your badge and program book at the INRC Registration Desk at the Manhattan Ballroom Foyer of the Lobby Level of Grand Hyatt New York (109 East 42nd Street at Grand Central Terminal). Scientific Presentations will be in the Manhattan Ball Room (see floor plan on page 134). Poster Sessions will be at the Museum Space (see floor plan on page 134). The list of poster titles and authors are on pages 42-51 Poster Session 1. Monday July 8th, 2019 Posters may be set up between 12:30 – 2:00 PM and should be removed by 7:00 PM. Presenters will be at their posters from 4:30 – 6:00 PM on Monday. Poster Session 2. Tuesday July 9th, 2019 Posters may be set up before 9:00 AM and should be removed by 7:00 PM. Presenters will be at their posters from 4:30 – 6:00 PM on Tuesday. Poster Session 3. Wednesday July 10th, 2019 Posters may be set up before 9:00 AM and should be removed by 3:00 PM. Presenters will be at their posters from 12:30 – 2:00 PM on Wednesday. Lunches will be served at the Gallery on Lex (see floor plan on page 134) from Monday through Wednesday and open to all delegates. Banquet will be at the Empire Ballroom III; the pre-Banquet reception will be at the Empire Ballroom Foyer (4th floor of Grand Hyatt New York). 4 Events Summary Sunday July 7, 2019 Welcome Reception - 7:00 PM – 9:00 PM Monday July 8, 2019 Welcome Address - 8:45 AM – 9:00 AM Plenary Lecture - 9:00 AM – 10:00 AM Mary Jeanne Kreek, Rockefeller University, NY, USA Symposium 1 - 10:00 AM – 12:40 PM Opioid Receptor Structure/Ultra Structure/Single Molecules Lunch - 12:30 PM – 2:00 PM Symposium 2 - 2:00 PM – 4:00 PM Biased Signaling Data Blitz 1 - 4:00 PM – 4:30 PM Poster Session 1 - 4:30 PM – 6:00 PM Tuesday July 9, 2019 Plenary Session - 9:00 AM – 10:00 AM George Koob, National Institute on Alcohol Abuse and Alcoholism, NIH, USA Nora Volkow, National Institute on Drug Abuse, NIH, USA Symposium 3 - 10:00 AM – 12:40 PM Albert Herz Memorial Symposium: Targeting Kappa Opioid Receptors Lunch - 12:30 PM – 2:00 PM Executive Committee meeting - 12:30 PM – 2:00 PM (by invitation only) Symposium 4 - 2:00 PM – 4:00 PM Gavril Pasternak Memorial Symposium: Chemical Biology oF Diverse Opioids Data Blitz 2 - 4:00 PM – 4:30 PM Poster Session 2 - 4:30 PM – 6:00 PM 5 Wednesday July 10, 2019 Founders’ Lecture - 9:00 AM – 10:00 AM Solomon H. Snyder, Johns Hopkins University, MD, USA Symposium 5 - 10:00 AM – 12:30 PM Circuits in Neuropathic Pain Poster session - 12:30 PM – 2:00 PM Lunch - 12:30 PM – 2:00 PM INRC Founders’ Round Table Discussion - 2:00 PM – 3:00 PM Career Development Session: Grant Writing Workshop - 3:30 PM – 5:00 PM Thursday July 11, 2019 Young Investigator Award Lecture - 9:00 AM – 10:00 AM Emily Jutkiewicz, University of Michigan, MI, USA Symposium 6 - 10:00 AM – 12:30 PM Endogenous Opioid System: Progress and New Concepts Lunch - 12:30 PM – 2:00 PM (On your own) Symposium 7 - 2:00 PM – 4:00 PM Atypical Opiates Business Meeting: 4:00 PM – 5:00 PM All attendees are encouraged to attend and elect new members of the executive committee. Conference updates, future meeting locations and other business will be discussed. Reception: 6:00 PM – 7:00 PM Banquet and Dance: 7:00 PM – 10:00 PM Banquet dinner ticket is in your registration packet. 6 INRC 2019 AWARDEE Founders’ Lecture – Professor Solomon Snyder Dr. Solomon H. Snyder is the Distinguished Service Professor of Neuroscience, Pharmacology and Psychiatry at the Johns Hopkins University School of Medicine. He is the founder of the Solomon H. Snyder Department of Neuroscience and served as its director from 1980 to 2006. Born in Washington, D.C. on December 26, 1938, Dr. Snyder received his undergraduate and medical training at Georgetown University (MD in 1962); Research Associate training with Julius Axelrod at the NIH (1963- 1965); and psychiatric training at the Johns Hopkins Hospital (1965-1968). In 1966 he joined the faculty of the Johns Hopkins University School of Medicine (Assistant Professor Pharmacology, 1966-1968; Associate Professor Pharmacology/Psychiatry (1968- 1970); Professor (1970)). In 1980 he established the Department of Neuroscience and served as Director (1980-2006). He is presently Distinguished Service Professor of Neuroscience, Pharmacology and Psychiatry. Dr. Snyder is the recipient of numerous professional honors, including the Albert Lasker Award for Basic Biomedical Research (1978), the National Medal of Science (2005), the Albany Medical Prize (2007), the Warren Alpert Prize, Harvard University Prize (2014); Honorary Doctor of Science degrees from Northwestern University (1981), Georgetown University (1986), Ben Gurion University (1990), Albany Medical College (1998), Technion University of Israel (2002), Mount Sinai Medical School (2004), University of Maryland (2006), Charles University, Prague (2009), Johns Hopkins University (2018); the Wolf Foundation Prize in Medicine (1983), the Dickson Prize of the University of Pittsburgh (1983), the Bower Award of the Franklin Institute (1991), the Bristol-Myers Squibb Award for Distinguished Achievement in Neuroscience Research (1996), the Gerard Prize of the Society for Neuroscience (2000) and the Salk Institute Science Award (2016). He is a member of the United States National Academy of Sciences and a Fellow of the American Academy of Arts and Sciences and the American Philosophical Society. He is the author of more than 1000 journal articles and several books including Uses of Marijuana (1971), Madness and the Brain (1974), The Troubled Mind (1976), Drugs and the Brain (1986), and Brainstorming (1989). Many advances in molecular neuroscience have stemmed from Dr. Snyder's identification of receptors for neurotransmitters and drugs, and elucidation of the actions of psychotropic agents, making him one of the most highly cited biologists in the world. His 1973 Science publication describing the opiate receptor was a major advance in the field. 7 INRC 2019 AWARDEE Young Investigator Award – Dr. Emily Jutkiewicz Dr. Emily Jutkiewicz is currently an Associate Professor with tenure in the Department of Pharmacology at the University of Michigan Medical School. She attended Tufts University in Medford, Massachusetts for her undergraduate studies and graduated cum laude with a B.S. in biopsychology. She worked for a couple of years as a research technician at McLean Hospital before starting graduate school in the Department of Pharmacology at the University of Michigan in the laboratory of Dr. James H Woods. She received her PhD in 2004 with a thesis entitled “Antidepressant effects of the nonpeptidic delta-opioid receptor agonist SNC80.” She completed postdoctoral fellowships at the University of Michigan in the mass spectrometry core facility and in the laboratories of Drs. Margaret Gnegy and Jim Woods. In 2009, she became a research investigator in the laboratory of Dr. John Traynor and then became a tenure-track faculty in 2013. Dr. Jutkiewicz’s research has focused on the behavioral effects of opioids and other drugs of abuse, such as nicotine and amphetamine. She identified that delta opioid receptor agonists produce antidepressant-like effects in animal models and determined that these effects were independent of their seizure activity. Her current research aims to elucidate further the role of opioid systems, in particular the delta opioid receptor, in disease states. More specifically, her laboratory investigates the in vivo effects of delta opioid and multifunctional opioid receptor ligands and the cellular mechanisms underlying the in vivo effects of delta opioid agonists. Her lab is also interested in identifying novel treatments for addiction. Thus far, Dr. Jutkiewicz has had a productive career. She has published 58 peer- reviewed journal articles and edited a volume of Handbook of Experimental Pharmacology on Delta Opioid Receptor Pharmacology and Therapeutic Applications (to which many INRC members contributed). In addition, she is a co-applicant on two patents and currently serves on the Editorial Boards for the journals Psychopharmacology, and Experimental and Clinical Psychopharmacology. She has also received grant awards from NIDA, NIMH, and the PhRMA Foundation.
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