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Impaired Hippocampus-Dependent and Facilitated Striatum-Dependent Behaviors in Mice Lacking the Delta Opioid Receptor
Neuropsychopharmacology (2013) 38, 1050–1059 & 2013 American College of Neuropsychopharmacology. All rights reserved 0893-133X/13 www.neuropsychopharmacology.org Impaired Hippocampus-Dependent and Facilitated Striatum-Dependent Behaviors in Mice Lacking the Delta Opioid Receptor 1 1,3 2 1 ,1 Julie Le Merrer , Xavier Rezai , Gre´gory Scherrer ,Je´roˆme AJ Becker and Brigitte L Kieffer* 1De´partement de Me´decine Translationnelle et Neuroge´ne´tique, Institut de Ge´ne´tique et de Biologie Mole´culaire et Cellulaire, 2 Illkirch, France; Department of Anesthesia, Stanford Institute for Neuro-Innovation and Translational Neurosciences, Stanford University School of Medicine, Palo Alto, CA, USA Pharmacological data suggest that delta opioid receptors modulate learning and memory processes. In the present study, we investigated whether inactivation of the delta opioid receptor modifies hippocampus (HPC)- and striatum-dependent behaviors. We first assessed HPC-dependent learning in mice lacking the receptor (Oprd1 À / À mice) or wild-type (WT) mice treated with the delta opioid antagonist naltrindole using novel object recognition, and a dual-solution cross-maze task. Second, we subjected mutant animals to memory tests addressing striatum-dependent learning using a single-solution response cross-maze task and a motor skill-learning task. Genetic and pharmacological inactivation of delta opioid receptors reduced performance in HPC-dependent object place recognition. Place learning À / À was also altered in Oprd1 animals, whereas striatum-dependent response and procedural learning were facilitated. Third, we À / À investigated the expression levels for a large set of genes involved in neurotransmission in both HPC and striatum of Oprd1 mice. Gene expression was modified for several key genes that may contribute to alter hippocampal and striatal functions, and bias striatal output towards striatonigral activity. -
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Efficacy and Safety of Gluten-Free and Casein-Free Diets Proposed in Children Presenting with Pervasive Developmental Disorders (Autism and Related Syndromes)
FRENCH FOOD SAFETY AGENCY Efficacy and safety of gluten-free and casein-free diets proposed in children presenting with pervasive developmental disorders (autism and related syndromes) April 2009 1 Chairmanship of the working group Professor Jean-Louis Bresson Scientific coordination Ms. Raphaëlle Ancellin and Ms. Sabine Houdart, under the direction of Professor Irène Margaritis 2 TABLE OF CONTENTS Table of contents ................................................................................................................... 3 Table of illustrations .............................................................................................................. 5 Composition of the working group ......................................................................................... 6 List of abbreviations .............................................................................................................. 7 1 Introduction .................................................................................................................... 8 1.1 Context of request ................................................................................................... 8 1.2 Autism: definition, origin, practical implications ........................................................ 8 1.2.1 Definition of autism and related disorders ......................................................... 8 1.2.2 Origins of autism .............................................................................................. 8 1.1.2.1 Neurobiological -
INTERNATIONAL NARCOTICS CONTROL BOARD FENTANYL-RELATED Substancesa with NO KNOWN LEGITIMATE USES
INTERNATIONAL NARCOTICS CONTROL BOARD a FENTANYL-RELATED SUBSTANCES WITH NO KNOWN LEGITIMATE USES Abbrev- CAS Intl No. Uses b Common Substance Name Other/ Alternative Substance Name(s) c iations No.d Ctrl.e 1 Unknown 2,2'-difluorofentanyl N-(1-(2-fluorophenethyl)piperidin-4-yl)-N-(2- fluorophenyl)propionamide; 2'-ortho-difluorofentanyl; 2'-fluoro ortho- fluorofentanyl 2 Unknown 2-fluoro butyrfentanyl N-(2-fluorophenyl)-N-(1-phenethylpiperidin-4-yl) butyramide 3 No 2-fluorofentanyl ortho-fluorofentanyl; N-(2-fluorophenyl)-N-(1-phenethylpiperidin-4- 2-FF; o-FF Known yl)propionamide Uses 4 Unknown 2-furanylethyl fentanyl N-[1-[2-(2-furanyl)ethyl]-4-piperidinyl]-N-phenyl-propanamide 1443-49- 8 (HCl) 5 Unknown 2-isopropylfuranyl fentanyl 2-isopropyl furanyl fentanyl; ortho-isopropyl furanyl fentanyl; N-(2- 2-isopropyl isopropylphenyl)-N-(1-phenethylpiperidin-4-yl)furan-2-carboxamide; Fu-F 2-Furanylfentanyl ortho-2-isopropylphenyl analogue 6 Unknown 2-methoxy furanyl fentanyl N-(2-methoxyphenyl)-N-[1-(2-phenylethyl)-4-piperidinyl]-2- 2-methoxy 101343- furancarboxamide; 2-Furanylfentanyl ortho-2-methoxyphenyl FuF; 2-Meo- 50-4 analogue; ortho-methoxy furanyl fentanyl FuF 7 Unknown 2-methyl furanyl fentanyl N-(1-phenethylpiperidin-4-yl)-N-(o-tolyl)furan-2-carboxamide 2-methyl FuF 8 Unknown 3-allyl fentanyl N-phenyl-N-[1-(2-phenylethyl)-3-(prop-2-en-1-yl)piperidin-4- 82208- yl]propanamide 84-2 9 Unknown 3-fluoro butyrfentanyl N-(3-fluorophenyl)-N-(1-phenethylpiperidin-4-yl) butyramide 10 Unknown 3-fluorofentanyl meta-fluorofentanyl; N-(3-fluorophenyl)-N-(1-phenethylpiperidin-4- -
Pharmaceutical Appendix to the Tariff Schedule 2
Harmonized Tariff Schedule of the United States (2007) (Rev. 2) Annotated for Statistical Reporting Purposes PHARMACEUTICAL APPENDIX TO THE HARMONIZED TARIFF SCHEDULE Harmonized Tariff Schedule of the United States (2007) (Rev. 2) Annotated for Statistical Reporting Purposes PHARMACEUTICAL APPENDIX TO THE TARIFF SCHEDULE 2 Table 1. This table enumerates products described by International Non-proprietary Names (INN) which shall be entered free of duty under general note 13 to the tariff schedule. The Chemical Abstracts Service (CAS) registry numbers also set forth in this table are included to assist in the identification of the products concerned. For purposes of the tariff schedule, any references to a product enumerated in this table includes such product by whatever name known. ABACAVIR 136470-78-5 ACIDUM LIDADRONICUM 63132-38-7 ABAFUNGIN 129639-79-8 ACIDUM SALCAPROZICUM 183990-46-7 ABAMECTIN 65195-55-3 ACIDUM SALCLOBUZICUM 387825-03-8 ABANOQUIL 90402-40-7 ACIFRAN 72420-38-3 ABAPERIDONUM 183849-43-6 ACIPIMOX 51037-30-0 ABARELIX 183552-38-7 ACITAZANOLAST 114607-46-4 ABATACEPTUM 332348-12-6 ACITEMATE 101197-99-3 ABCIXIMAB 143653-53-6 ACITRETIN 55079-83-9 ABECARNIL 111841-85-1 ACIVICIN 42228-92-2 ABETIMUSUM 167362-48-3 ACLANTATE 39633-62-0 ABIRATERONE 154229-19-3 ACLARUBICIN 57576-44-0 ABITESARTAN 137882-98-5 ACLATONIUM NAPADISILATE 55077-30-0 ABLUKAST 96566-25-5 ACODAZOLE 79152-85-5 ABRINEURINUM 178535-93-8 ACOLBIFENUM 182167-02-8 ABUNIDAZOLE 91017-58-2 ACONIAZIDE 13410-86-1 ACADESINE 2627-69-2 ACOTIAMIDUM 185106-16-5 ACAMPROSATE 77337-76-9 -
Appendix-2Final.Pdf 663.7 KB
North West ‘Through the Gate Substance Misuse Services’ Drug Testing Project Appendix 2 – Analytical methodologies Overview Urine samples were analysed using three methodologies. The first methodology (General Screen) was designed to cover a wide range of analytes (drugs) and was used for all analytes other than the synthetic cannabinoid receptor agonists (SCRAs). The analyte coverage included a broad range of commonly prescribed drugs including over the counter medications, commonly misused drugs and metabolites of many of the compounds too. This approach provided a very powerful drug screening tool to investigate drug use/misuse before and whilst in prison. The second methodology (SCRA Screen) was specifically designed for SCRAs and targets only those compounds. This was a very sensitive methodology with a method capability of sub 100pg/ml for over 600 SCRAs and their metabolites. Both methodologies utilised full scan high resolution accurate mass LCMS technologies that allowed a non-targeted approach to data acquisition and the ability to retrospectively review data. The non-targeted approach to data acquisition effectively means that the analyte coverage of the data acquisition was unlimited. The only limiting factors were related to the chemical nature of the analyte being looked for. The analyte must extract in the sample preparation process; it must chromatograph and it must ionise under the conditions used by the mass spectrometer interface. The final limiting factor was presence in the data processing database. The subsequent study of negative MDT samples across the North West and London and the South East used a GCMS methodology for anabolic steroids in addition to the General and SCRA screens. -
WO 2017/066488 Al
(12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (10) International Publication Number (43) International Publication Date W O 2017/066488 A l 2 0 April 2017 (20.04.2017) P O P C T (51) International Patent Classification: (81) Designated States (unless otherwise indicated, for every A61K 31/485 (2006.01) A61P 25/04 (2006.01) kind of national protection available): AE, AG, AL, AM, A61K 31/5415 (2006.01) A61P 1/08 (2006.01) AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, (21) International Application Number: DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, PCT/US20 16/0569 10 HN, HR, HU, ID, IL, EST, IR, IS, JP, KE, KG, KN, KP, KR, (22) International Filing Date: KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, 13 October 2016 (13.10.201 6) MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, (25) Filing Language: English SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, (26) Publication Language: English TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (30) Priority Data: 62/240,965 13 October 2015 (13. 10.2015) US (84) Designated States (unless otherwise indicated, for every 62/300,014 25 February 2016 (25.02.2016) US kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, (71) Applicant: CHARLESTON LABORATORIES, INC. -
(12) Patent Application Publication (10) Pub. No.: US 2014/0144429 A1 Wensley Et Al
US 2014O144429A1 (19) United States (12) Patent Application Publication (10) Pub. No.: US 2014/0144429 A1 Wensley et al. (43) Pub. Date: May 29, 2014 (54) METHODS AND DEVICES FOR COMPOUND (60) Provisional application No. 61/887,045, filed on Oct. DELIVERY 4, 2013, provisional application No. 61/831,992, filed on Jun. 6, 2013, provisional application No. 61/794, (71) Applicant: E-NICOTINE TECHNOLOGY, INC., 601, filed on Mar. 15, 2013, provisional application Draper, UT (US) No. 61/730,738, filed on Nov. 28, 2012. (72) Inventors: Martin Wensley, Los Gatos, CA (US); Publication Classification Michael Hufford, Chapel Hill, NC (US); Jeffrey Williams, Draper, UT (51) Int. Cl. (US); Peter Lloyd, Walnut Creek, CA A6M II/04 (2006.01) (US) (52) U.S. Cl. CPC ................................... A6M II/04 (2013.O1 (73) Assignee: E-NICOTINE TECHNOLOGY, INC., ( ) Draper, UT (US) USPC ..................................................... 128/200.14 (21) Appl. No.: 14/168,338 (57) ABSTRACT 1-1. Provided herein are methods, devices, systems, and computer (22) Filed: Jan. 30, 2014 readable medium for delivering one or more compounds to a O O Subject. Also described herein are methods, devices, systems, Related U.S. Application Data and computer readable medium for transitioning a Smoker to (63) Continuation of application No. PCT/US 13/72426, an electronic nicotine delivery device and for Smoking or filed on Nov. 27, 2013. nicotine cessation. Patent Application Publication May 29, 2014 Sheet 1 of 26 US 2014/O144429 A1 FIG. 2A 204 -1 2O6 Patent Application Publication May 29, 2014 Sheet 2 of 26 US 2014/O144429 A1 Area liquid is vaporized Electrical Connection Agent O s 2. -
Rubiscolins Are Naturally Occurring G Protein-Biased Delta Opioid Receptor Peptides
European Neuropsychopharmacology (2019) 29, 450–456 www.elsevier.com/locate/euroneuro SHORT COMMUNICATION Rubiscolins are naturally occurring G protein-biased delta opioid receptor peptides a , 1 a, 1 a Robert J. Cassell , Kendall L. Mores , Breanna L. Zerfas , a a, b , c a ,b , c Amr H. Mahmoud , Markus A. Lill , Darci J. Trader , a, b ,c , ∗ Richard M. van Rijn a Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, Purdue University, West Lafayette, IN 47907, USA b Purdue Institute for Drug Discovery, West Lafayette, IN 47907, USA c Purdue Institute for Integrative Neuroscience, West Lafayette, IN 47907, USA Received 6 August 2018; received in revised form 19 November 2018; accepted 16 December 2018 KEYWORDS Abstract Delta opioid receptor; The impact that β-arrestin proteins have on G protein-coupled receptor trafficking, signaling Beta-arrestin; and physiological behavior has gained much appreciation over the past decade. A number of Natural products; studies have attributed the side effects associated with the use of naturally occurring and syn- Biased signaling; thetic opioids, such as respiratory depression and constipation, to excessive recruitment of Rubisco; β-arrestin. These findings have led to the development of biased opioid small molecule ago- G protein-coupled nists that do not recruit β-arrestin, activating only the canonical G protein pathway. Similar G receptor protein-biased small molecule opioids have been found to occur in nature, particularly within kratom, and opioids within salvia have served as a template for the synthesis of other G protein- biased opioids. Here, we present the first report of naturally occurring peptides that selectively activate G protein signaling pathways at δ opioid receptors, but with minimal β-arrestin recruit- ment. -
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Federal Register / Vol. 60, No. 80 / Wednesday, April 26, 1995 / Notices DIX to the HTSUS—Continued
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