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Nitric Oxide's Role in Biology

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Nitric Oxide's Role in Biology 2008 ANNUAL MEETING THEMATIC OVERVIEWS INSIDE August 2007 Nitric Oxide’s Role in Biology American Society for Biochemistry and Molecular Biology Promoting Understanding of the Molecular Nature of Life Processes The Society’s purpose is to advance the science of biochemistry and molecular biology through publication of scientific and educational journals (the Journal of Biological Chemistry, Molecular & Cellular Proteomics, and the Journal of Lipid Research), organization of scientific meetings, advocacy for funding of basic research and education, support of science education at all levels, and promoting the diversity of individuals entering the scientific workforce. www.asbmb.org contents AUGUST 2007 ON THE COVER: Nitric oxide affects many organs, including the heart. society news Jonathan S. Stamler has spent much of his career explaining 2 President’s Message how this molecule works. 6 Washington Update 28 7 Assessing Minority Programs 8 Ten ASBMB Members Elected to Academy 9 Retrospective: John M. Buchanann 2008 meeting overview 12 Lipid Signaling and Metabolism 14 Signal Transduction etrospective: ohn M. Buchanann 16 RNA-Mediated Gene Expression 917-2007) 9 18 Cell and Organelle Dynamics science focus 28 Jonathan S. Stamler: Nitric Oxide’s Role in Biology and Medicine departments 3 Letter to the Editor 4 News from the Hill 10 Member Spotlight 20 Career Insights Educatingg Non Scientists 22 22 Education and Training Educating Non-Scientists 22 Postdoc Brain Circulation 24 26 BioBits resources 31 For Your Lab 32 Career Opportunities 33 Scientific Meeting Calendar Replicating Damaged DNA 26 August 2007 ASBMB Today 1 president’smessage A monthly publication of The American Society for An ASBMB delegation Biochemistry and Molecular Biology led by Heidi Hamm is Officers currently in China. Heidi E. Hamm President Gregory A. Petsko President-Elect Mark A. Lemmon Secretary The President’s Merle S. Olson Treasurer Message will return Council Members in the September Alan Hall Kuan-Teh Jeang issue of the magazine. Suzanne R. Pfeffer Linda J. Pike John D. Scott Joan A. Steitz Kevin Struhl James A. Wells Ex-Officio Members Ellis Bell Chair, Education and Professional Development Committee Laurie S. Kaguni Chair, Meeting Committee George Hill Chair, Minority Affairs Committee Kendall J. Blumer Anna Marie Pyle Co-chairs, 2008 Program Committee Mary J. C. Hendrix Chair, Public Affairs Advisory Committee Robert E. Rhoads Chair, Publications Committee Herbert Tabor Editor, JBC Ralph A. Bradshaw A. L. Burlingame Co-editors, MCP Edward A. Dennis Editor, JLR ASBMB Today Editorial Advisory Board Alex Toker Chair Mike Autry Greg P. Bertenshaw Craig E. Cameron Irwin Fridovich Richard W. Hanson Elizabeth A. Komives Bettie Sue Masters Luke A. O’Neill Duanqing Pei Carol C. Shoulders Robert D. Wells ASBMB Today Nicole Kresge Editor [email protected] Pat Pages Science Writer [email protected] Nancy J. Rodnan Director of Publications [email protected] Barbara Gordon Executive Director [email protected] Magazine design & production: Amy Phifer For information on advertising contact FASEB AdNet at 800-433-2732 ext. 7157 or 301-634-7157, or E-mail [email protected]. www.asbmb.org August 2007 firstletterssecondto the editor words things: I wanted to have children ing uncertainty and a never ending Leaving and enjoy time with them, I wanted instability in an academic career that to have enough money to send my never stops demanding all of her Academic kids to college and retire at a decent time. Basically she sees her inter- age, and I did not want to work in a est in science as incompatible with Science profession that required me to work academic research. To the Editor: seven days a week.” The National Institutes of Health In the May 2007 issue of ASBMB The young woman who wrote (NIH) funding crisis, the poor job Today, there was a profile of ay oung this article identifies several critical prospects in academic science, the woman investigator [Rashmi Nem- points. One is of course the issue permanent postdocs, and the family- ade, Career Insights, pages 18-19] we are all familiar with, the issue of unfriendliness of the profession are a who, like so many young women, has balancing family and work. dangerous combination. left academic science for an “alterna- Second, there is a strong sense With even senior investigators tive career.” In the article she says: of reluctance to embark on a career losing grants and salaries, with jobs “I was disenchanted by the academic that requires long hours and poor few and far between and often dis- tant from family, with the demands lifestyle, i.e. lots of hard work and remuneration. “I want to have of our institutions on our time even personal sacrifice for risky gains. I enough money to send my kids to greater, really, why would anyone looked around my lab and found college and retire at a decent age,” who wants to be involved in science that even the brightest, hardest she writes. Now, I will argue that choose academe? I fear that this working, dedicated, and well pub- anyone who has achieved a Ph.D. effect will disproportionately affect lished scientists were, after at least a and a postdoc is not afraid of hard work per se. But clearly this young under-represented groups in science, year or two of interviewing, landing woman saw no end to it and no making the gap seem more insur- academic positions at institutions way to accomplish her life goals in mountable. I have already seen an that were not their first choices. an academic setting. Bright people increase in women graduate students My colleagues that got academic with doctoral education have lots of deciding against academic postdocs positions had to work seven days a other ways to make money than on because they feel it is too stressful on week trying to prove to their new partial-year salaries at a university; top of everything else. department members that they the brightest are perhaps the least Therefore, I think that the women were worthy of the appointment. In likely to stay. in science groups need to address the long run, I didn’t want to work Third and most disturbing to me the hypothesis that the funding crisis that hard for that long and make so is her perception of academic science in biomedical science is going to many personal sacrifices, i.e. time as high risk and low return. For long disproportionately affect recruitment with family for a last choice institu- hours and hard work, she sees the and retention of women at all levels tion and a low salary. likelihood of ending up in a place in academic institutions. “The real turning point came when where she wants to work as low, she Susan L. Forsburg I realized that children could, sees little financial reward and a lot University of Southern should, and would be a part of my of financial risk, and she sees fund- California future. Both my husband, who is not a scientist, and I had demand- ing careers and had not planned on Tell Us What You Think having children, but the feeling was We appreciate receiving letters that are suitable for publication growing, and I was worried about regarding issues of importance or comment on articles appearing how we would balance family and in ASBMB Today. Letters should be sent to the editor at the work. I did a lot of soul searching address found in the masthead. Letters must be signed and must contain the writer’s addresss and telephone number. and looked deeply and seriously The editor reserves the right to edit all letters. into my future and realized a few August 2007 ASBMB Today 3 news from the hill 2008 NIH Funding Advances in House, Senate BY PETER FARNHAM arly July saw progress on National Institutes of EHealth (NIH) funding for FY 2008 in both House and Senate—but the amount of money involved is not what the biomedical research community had been anticipating. On July 11, the House Appropriations Committee approved a total of $29.65 billion for NIH, an increase of match biomedical inflation, expected to be 3.7% this year. $750 million (2.6%) above FY 2007 and $1.029 billion Other major groups that are not supporting the bill are the (3.6%) above the President’s request. But the committee American Heart Association, the American Cancer Society, also kept the provision contained in the bill approved by and Research!America. the subcommittee on Labor, Health and Human Services, Education and Related Agencies (L/HHS) to increase the Meanwhile, in the Senate… amount of the transfer from NIH to the Global HIV/AIDS The Senate Appropriations Subcommittee on L/HHS did fund from $99 million this year to $300 million in FY 2008. slightly better for NIH funding during its June 19 markup, NIH thus receives only $549 million under the House bill, recommending that NIH receive an additional $800 million less than a 2% increase. in FY 2008, a 2.8% increase (after a $200 million transfer to Appropriations Committee Chairman David Obey (D-WI) the Global AIDS program). The bill was approved by the full tried to put the best face on the proposal, commenting that Senate appropriations committee on June 21. it provides $1 billion more than the President requested and Chairman Tom Harkin (D-IA) pointed out during the that this will allow NIH to increase (by 545) the number of markup that the House L/HHS subcommittee had $2 new and competing research grants funded in FY 2008. He billion more to distribute among its programs than he did also noted that the $620 million increase NIH received in FY (due to the vagaries of the appropriations process, which 2007 is allowing NIH to support important initiatives, as well proceed largely on parallel but separate tracks in the as an additional 992 research grants.
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