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Animal Physical experiments Mixing and Tablet property wing Equipment Biochemical testing granulation measure- pressing and room room room coating room ment Research room

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1F Exhibition Direc- Warehouse Drug discovery Testing Training lobby Research- Pharmacological Entrance tor's room room room ers' room testing room

hall room Garage

ing room ing Air condition Air

Institute of Health

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Equip- tempera- ture and Sample inspection Medicine testing room ment

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equipment Book storage Research condition Air

wing Toyama Prefectural Institute for Pharmaceutical Research

Japanese/

Chroma- Japanese/ Browsing

2F Chinese Special tographic Chinese Research- Biotechnology medicine equipment

ingredient testing medicine ers' room research room room testing room room

preparation Cleaning Drug tool

Crude drug Crudedrug room Dark room room storageroom room Center for Innovation in

Research Center for Drug Pharmaceutical Development and Development and Quality Control Access Drug Delivery

To Takaoka

Prefectural Route, Toyama Takaoka Line Niigata Prefecture Imizu City, Joetsumyoko Toyama Prefecture Itoigawa ⚫ Toyama Prefectural University Prefectural Route, Iiyama Toyama Toide Oyabe Line Kurobe- Ainokaze Unazuki- Toyama Railway South Line South Shin Toyama onsen KosugiStation Prefectural Route, Takaoka Nagano Kushida Shin - Kurokawa Line Toyama Prefecture ⚫ Taikoyama Land Kanazawa Nagano Prefectural Park Prefecture Hokuriku Expressway Ishikawa Prefecture Hokuriku Kosugi Gifu Interchange Prefecture Shinkansen

Fukui Prefecture To Kosugi Station On foot: Environmental Science About 30 minutes from Kosugi Station South Exit Research Center Public transportation Entrance (the "Kosugi Station - Taikoyama Line" Imizu Community Bus):

Management Wing Get on at "Kosugi Station South Exit" and get off at "Environmental Science Research Center (Kankyo Kagaku Center Mae)" (a bus ride of about 6 minutes) Institute of Health By car: About 5 minutes from Kosugi Station South Exit

Center for Innovation in Pharmaceutical KosugiStation Line South Development and Drug Delivery About 30 minutes from JR South Exit (Main Exit), about Entrance Institute for 20 minutes from JR Shin-, about 30 minutes from Pharmaceutical Research Toyama Airport Parking Research Center for About 7 minutes from the Hokuriku Expressway Toyama-nishi Drug Development and Quality Control Interchange About 7 minutes from the Hokuriku Expressway Kosugi Interchange To Taikoyama Land Prefectural Park

Toyama Prefectural Institute for Pharmaceutical Research Center for Innovation in Pharmaceutical Development and Drug Delivery 17-1 Nakataikoyama, Imizu, Toyama 939-0363 TEL 0766-56-6026 FAX 0766-56-7285 HP: http://www.pref.toyama.jp/branches/1285/

Center for Innovation in Pharmaceutical Development and Drug Delivery —Reinforcement of base function of support for pharmaceutical development and research and research of medicinal study—

Japanese/Chinese medicine testing room Equipment room Laboratory table for work and draft chamber are placed. Various type of liquid chromatography including ultra-high performance liquid chromatography is available.

Mixing and granulation room Physical property measurement room Equipment room Machines are placed in zones depending The latest equipment for measuring physical Both manual type and automatic elution test on the process they are used for properties is available, including a taste device are placed. recognition device Tablet pressing and coating room Research Partitions are movable, and can wing be removed to form a large 2F laboratory, ideal for training Constant temperature and humidity room Institute of students or giving Research Various type of equipment was placed in area where Health demonstrations of machinery temperature and humidity are controlled. Air wing conditioning Sample inspection 1F Constant room temperature and room humidity room Animal Biochemical Medicine testing Equipment experiments Large testing room wing room room Book storage equipment Biotechnology room Dark room Physical Equipment research room Browsing Tablet property room Researchers' Special Cleaning Mixing and pressing and measurement Warehouse Drug tool room equipment room granulation coating room room Chromatographic room room Research Center for room testing room Pharmacological Japanese/Chinese Japanese/Chinese Drug Development Garage Director's testing room medicine ingredient medicine testing and Quality Control Researchers' preparation room Exhibition room Crude drug room Entrance room storage room Training lobby hall Testing Drug room room Air conditioning discovery room room

Testing room Browsing Special equipment room The multipurpose laboratories can be Technical books and academic magazines are available Atomic absorption spectrophotometer and various type used by pharmaceutical companies or for browsing of gas chromatography are placed. used for training students

Drug discovery room Training room Equipment for research such as confocal laser There is a large screen for giving lectures Utilized for training for university students and high school students. microscope are placed. to students or seminars Weighing room and dark room are also newly prepared.

Production equipment (granulation device Production equipment and property and grain size controller) measuring device Can handle the entire tablet or granule manufacturing process, Can measure the physical properties of powders, granules and following the manufacturing stages for sold formulations tablets

Major stages in manufacturing tablets

Mixing and Granule PTP Rotary tablet press Multi-tip tools Pressing Film coating granulation processing packaging This device has 12 mortars Molding die for tablet and pestles attached to a press required for turntable, and each time the tableting of mini tablet turntable rotates, the drug with a diameter from 1 Fluid bed granulator Complex type fluidized- substance is packed, mm to 4 mm. Shape of compressed, decompressed the tip divides into several This device uses a hot air flow bed granulator and expelled in a continuous parts compared with to send granules downwards, This device uses a hot air flow to process, to form tablets. It can regular punch, several prototypes of tablets can then sprays them with binder send raw material powder manufacture up to 20,000 solution to granulate them. upwards and processing of be produced in one tablets per hour. batch. This produces light and highly granule applicable for various [Model: VELAS KIKUSUI porous granules which are usage is possible by SEISAKUSHO LTD.] Structure of the tip is exchangeable. [Model: diameter 1.5, 2, 3, 4 mm Pharmachine] suitable for tablet pressing. replacement of milling blade and [Model: FL-LABO Freund Corporation] granulation container. Coating with micro particle is possible. [Model: FD-MP-01D Powrex Corporation] Tablet film coating device Semi-automatic PTP This device film-coats tablets packaging device by sending them into a pan Device used for packaging of with a circular cross-section tablets, etc. separately one by Dry granulator High shear mixer and drying them while one with thin metal such as This device forms flakes of This device makes granules by spraying them with coating aluminum and plastic sheet. It raw materials by rotating stirring blades on the fluid. is usable for packaging test Using a combination of a low- and stability test. compressing raw material floor of the container and milling [[Model: K-200KS-DK powder with two rolls, and blades on the sides at high pressure aeration drying Daiwa Kasei Industry Co., Ltd.] pulverizes and processes speed. structure and a quantitative them to form granules with As it produces heavy spherical spraying system, it can coat exclusive granulator. granules, it is suited to the tablets evenly in a short time. manufacture of granulated [Model: HC-LABO Freund Corporation] As it does not use water, it can be used for bulk drugs. drugs that are unstable in water. Oral disintegrating tablet testing device [Model: Roller compactor Freund Corporation] [Model: High speed mixer 5 EARTHTECHNICA CO. LTD.] This is a testing device for Multifunctional assessing the disintegration of Extrusion granulator (Basket type) Extrusion powder property oral disintegrating tablets. A granulator measuring device tablet is placed on a highly This device kneads binding agent porous board, and when together with the raw material (Screw type) This device can measure many measurement starts, a rotating powder then forces the resulting This device kneads physical properties of powders, weight descends, and when it mixture, through a screen by binding agent together including bulk, density touches the tablet, the water extrusion to form granules. As (loose/hard), angle of repose level in the container is well as manufacturing granules, it with the raw material powder then forces the and degree of agglomeration. adjusted, and warm water is can also be used together with a supplied through the porous resulting mixture, through It can be used to assess the spheronizer (Marumerizer) to board. a screen by extrusion to physical properties of raw make spherical granules. The time when the tablet [Model: HU-G HATA TEKKOSHO CO., LTD.] form granules. materials and granules. [Model: Multi tester (MT-1001) SEISHIN ENTERPRISE CO., LTD.] disintegrates and the weight Both axial extrusion (dome shape and plane) and touches the porous board is radial extrusion is available. detected, and the disintegration [Model: Multigran MG-55 DALTON CORPORATION] time is automatically measured. [Model: ODT-101 TOYAMA SANGYO CO., LTD.] Tablet hardness tester Granule shaper Vibrating filter This testing device Moisture meter This device presses the raw This device generates automatically material onto a conical screen horizontal and vertical measures the This is a heat drying moisture using spinning impeller blades motion by motor and hardness of pressed meter which automatically to shape granules. It is mainly vibrating body and tablets. It can measure measures the water content of suited to shaping the large, screens raw material on the hardness of tablets granules or tablets. The sieve surface (net). coarse granules produced by with diameters of 3 to measured water content is Adaptive to sieve with stirring granulation methods, 15 mm up to 300 N shown, down to a minimum 300 mm in diameter. level of 0.01%. and can be used for both wet [Model: 300-MM and print out the [Model: MX-50 A&D Company, Limited] and dry granulation. TSUTSUI SCIENTIFIC INSTRUMENTS results. CO., LTD.] [Model: Tc -Lab EARTHTECHNICA CO. LTD.] [Model: Portable checker PC-30 OKADA SEIKO CO., LTD.]

Equipment for Pharmaceutical Research Analysis equipment

Taste recognition device (taste sensor) Gas chromatograph with automatic headspace sampler

Can quantify bitterness and assess masking effects Can measure the amounts of residual solvents in medicines Overview of device This device uses sensors to assign numerical values to the taste of substances such as drugs to analyze them. Purpose It allows objective assessment of how effectively bitter drugs are masked. It can express tastes (such as bitterness, sweetness and sourness) as numerical values.

Specification Measures the amounts of Model: TS-5000Z (Intelligent Sensor Technology, Inc.) residual solvents in medicines Items measured: Bitterness (foretaste/aftertaste), sourness, sweetness Various sensors detect Tastes are expressed tastes as numerical values Has space for 90 samples Overview of device This device analyzes vaporized volatile compounds using a gas chromatograph. Laser diffraction particle size analyzer Purpose It can analyze the volatile ingredients of medicines and bulk drugs, for the purpose of pharmaceutical development and quality control. Can make both dry and wet measurements of particle Specification Headspace analysis system (gas chromatograph with headspace sampler and FID),

size distribution, for sizes from nanometers to millimeters Model: HS-20、GC-2010 plus (Shimadzu Corporation)

Overview of device Displays particle size distributions and light This device measures and analyzes the particle sizes of powders intensities in real time (raw materials for drugs) or granules. Purpose It can measure particle size distributions and mean particle sizes of raw materials or granules, and assess their physical properties. Gas chromatograph with ECD and FID and gas Specification Model: SALD2300 (Shimadzu Corporation) chromatograph mass spectrometer Measurement method: Full wet/dry measurement system Measurement range: 17 nm to 2.5 mm Can check and measure amounts of a variety of ingredients

Overview of device This device isolates chemical substances such as medicine in Vacuum freeze dryer gaseous form, and finds qualitative and quantitative information on them. Laboratory scale freeze drying is available with automatic tight plugging function Purpose It can analyze medicines, residual Overview of device Since the device can dry material in low temperature fertilizers in herbal drugs, and without applying heat, dried material is available avoiding dangerous drugs. damage of component or tissue. Purpose Preparation of extract of natural products, pilot manufacturing of Specification specialized tablet with high porosity and freeze drying of injectable Gas chromatograph with ECD and FID preparation (antibiotic drug or peptide formulation) and gas chromatograph mass Specification spectrometer Model: FZ-18/STD type (ASAHI LIFE SCIENCE CO., LTD.) Model: GC‐2014, Trap capacity: 18L ‐ Rack temperature: preliminary freezable, program settable, with GCMS QP2010 SE sample temperature sensor (Shimadzu Corporation) Other: Automatically tightly plugging and connectable to flask Measures residual amounts of fertilizer

Analysis equipment Equipment for research and development of drug Study equipment that support research and development of drug is placed Atomic absorption spectrophotometer Confocal laser scanning microscope Box-shaped fluorescence microscope Measurable of metal content in pharmaceutical This device makes target molecules from tissue sections or This is a box-shaped fluorescence microscope which does products or raw material of drugs cultured cells visible, by causing reactions with not require a dark room. fluoresceinated substances such as antibodies. It includes the "fluorescence," "phase contrast" and "bright Overview of device It can analyze localized changes to molecules inside a living field" viewing modes and imaging modes include "normal," body when a drug is administered, or localized changes to a "Z-stack" and "stitching," allowing viewing and recording of This device is used for measurement of metal content and in fluoresceinated polymer drug inside a living body. samples such as tissue sections with easy operations. addition to flame analysis, furnace analysis for more high sensitive analysis is available. Mercury analysis by reduced evaporated atomic absorption photometry is also possible. Purpose Measurement of metal content for impurity study of pharmaceutical products. Specification Atomic absorption spectrophotometer Model: AA-7000 Flame/furnace system (Shimadzu Corporation)

High-pressure liquid chromatograph Real time PCR device Frozen section preparation device Analysis time is remarkably shortened compared This device uses a system with an integrated gene This device is for creating thinly sliced sections for ° with regular liquid chromatography amplification device and spectrofluorometer to perform specimens at low temperatures of -16 to -20 C from simultaneous amplification and detection of DNA via PCR in frozen tissue. a single tube, and detect and analyze the generated amount As frozen sections are Overview of device of the amplified product in real time. not exposed to high This device is used for separation of elements in pharmaceutical drugs, It can perform 4 types of simultaneous gene expression temperatures, alcohol or etc. and qualitative and quantitative analysis. Since it corresponds to analysis (multiplexing). organic solvents, the ultra-high pressure, rapid high-separation analysis using column with device is particularly particle size of about 2 micro meters is possible. good for histochemical Purpose detection of enzymes, proteins, amino acids and Quantitative study for quality control of pharmaceutical products and the like. element analysis of crude drugs. Specification Ultra-high performance liquid chromatography with photodiode array detector: ACQUITY UPLC H Class System (Nippon Waters K.K.)

In-vivo imaging device Safety cabinet Fully automatic elution testing device This device detects weak light emissions or fluorescence The class II safety cabinet is experimental equipment for inside a living body, without killing the animal. enclosing biohazardous materials such as pathogens or Fully automated from implementation of elution It can be used with mice suitable for light emission or genetically modified organisms, and enables work to be fluorescence imaging to analyze the expression of test to cleaning work. done under sterile conditions. molecules related to disease or the aggregation of cancer Overview of device cells over time. *Located in the animal experiment wing This device investigates the elution of the active ingredients of pharmaceuticals. Purpose It can find the elution curve (a graph showing the relationship between elution rate and elution time) for solid oral pharmaceuticals. Specification • Automatic elution test device Model: RT-3Std (DAI NIPPON SEIKI CO., LTD.) • Spectrophotometer Model: UV-1850 (Shimadzu Corporation)