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BMJ Open Is Committed to Open Peer Review. As Part of This Commitment We Make the Peer Review History of Every Article We Publish Publicly Available BMJ Open: first published as 10.1136/bmjopen-2020-042953 on 25 February 2021. Downloaded from BMJ Open is committed to open peer review. As part of this commitment we make the peer review history of every article we publish publicly available. When an article is published we post the peer reviewers’ comments and the authors’ responses online. We also post the versions of the paper that were used during peer review. These are the versions that the peer review comments apply to. The versions of the paper that follow are the versions that were submitted during the peer review process. They are not the versions of record or the final published versions. They should not be cited or distributed as the published version of this manuscript. BMJ Open is an open access journal and the full, final, typeset and author-corrected version of record of the manuscript is available on our site with no access controls, subscription charges or pay-per-view fees (http://bmjopen.bmj.com). If you have any questions on BMJ Open’s open peer review process please email [email protected] http://bmjopen.bmj.com/ on October 1, 2021 by guest. Protected copyright. BMJ Open BMJ Open: first published as 10.1136/bmjopen-2020-042953 on 25 February 2021. Downloaded from Additional Treatments to the Local tumour for metastatic prostate cancer: Assessment of Novel Treatment Algorithms, a multicentre, phase II randomised controlled trial (IP2-ATLANTA) ForJournal: peerBMJ Open review only Manuscript ID bmjopen-2020-042953 Article Type: Protocol Date Submitted by the 24-Jul-2020 Author: Complete List of Authors: Connor, Martin; Imperial College London, Department of Surgery and Cancer; Imperial College Healthcare NHS Trust, Imperial Urology Shah, Taimur T; Imperial College London, Department of Surgery and Cancer Smigielska, Katarzyna; Imperial College London, Department of Surgery and Cancer; Imperial College London, Imperial College Clinical Trials Unit Day, Emily; Imperial College London, Imperial College Clinical Trials Unit Sukumar, Johanna; Imperial College London, Department of Surgery and Cancer; Imperial College London, Imperial College Clinical Trials Unit Fiorentino, Francesca; Imperial College London, Imperial College Clinical Trials Unit Sarwar, Naveed; Imperial College Healthcare NHS Trust, Department of Oncology http://bmjopen.bmj.com/ Gonzalez, Michael; Imperial College Healthcare NHS Trust, Department of Oncology Falconer, Alison; Imperial College Healthcare NHS Trust, Department of Oncology Klimowska-Nassar, Natalia; Imperial College London, Department of Surgery and Cancer; Imperial College London, Imperial College Clinical Trials Unit Evans , Martin; Imperial College London, Department of Surgery and Cancer on October 1, 2021 by guest. Protected copyright. Naismith, Olivia; Royal Marsden NHS Foundation Trust, Radiotherapy Trials Quality Assurance (RTTQA) Thippu Jayaprakash, Kamalram; Addenbrooke's Hospital, Department of Oncology Price, Derek; Imperial College London, Department of Surgery and Cancer Gayadeen, Shiva; Imperial College Healthcare NHS Trust, Department of Oncology Basak, Dolan; Imperial College Healthcare NHS Trust, Department of Oncology Horan, Gail; Addenbrooke's Hospital, Department of Oncology McGrath, John; Royal Devon and Exeter NHS Foundation Trust, Urology Sheehan, Denise; Royal Devon and Exeter NHS Foundation Trust, Department of Oncology Kumar, Manal; Arrowe Park Hospital, Department of Urology Ibrahim , Azman; Clatterbridge Cancer Centre NHS Foundation Trust, For peer review only - http://bmjopen.bmj.com/site/about/guidelines.xhtml Page 1 of 39 BMJ Open BMJ Open: first published as 10.1136/bmjopen-2020-042953 on 25 February 2021. Downloaded from 1 2 3 Department of Clinical Oncology 4 Brock, Cathryn; Chelsea and Westminster Hospital NHS Foundation 5 Trust, Department of Oncology 6 Pearson, Rachel; Newcastle Upon Tyne Hospitals NHS Foundation Trust, 7 Department of Oncology 8 Anyamene , Nicola; London North West University Healthcare NHS Trust, 9 Department of Oncology Heath , Catherine; University Hospital Southampton NHS Foundation 10 Trust, Department of Radiotherapy 11 Shergill, Iqbal; Wrexham Maelor Hospital, Department of Urology 12 Rai, Bhavan; Newcastle Upon Tyne Hospitals NHS Foundation Trust, 13 Department of Urology 14 Hellawell, Giles; London North West University Healthcare NHS Trust, 15 Department of Urology 16 Mccracken, Stuart; Sunderland Royal Hospital, Department of Urology For peerKhoubehi, Bijan; review Chelsea and Westminster only Healthcare NHS Trust, 17 Department of Urology 18 Mangar, Stephen; Imperial College Healthcare NHS Trust, Department of 19 Oncology 20 Khoo, Vincent; Royal Marsden NHS Foundation Trust, Department of 21 Oncology 22 Dudderidge, Tim; University Hospital Southampton NHS Foundation Trust, Department of Urology 23 Staffurth, John; Velindre Cancer Centre, Research; Cardiff University 24 School of Medicine, Division of Cancer and Genetics 25 Winkler, Mathias; Imperial College London, Department of Surgery and 26 Cancer; Imperial College Healthcare NHS Trust, Imperial Urology 27 Ahmed, Hashim; Imperial College London Division of Surgery, Imperial 28 College London 29 Prostate disease < UROLOGY, Radiation oncology < RADIOTHERAPY, 30 Keywords: RADIOTHERAPY, UROLOGY, Urological tumours < UROLOGY, 31 Genitourinary imaging < RADIOLOGY & IMAGING 32 33 34 http://bmjopen.bmj.com/ 35 36 37 38 39 40 41 42 on October 1, 2021 by guest. Protected copyright. 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 For peer review only - http://bmjopen.bmj.com/site/about/guidelines.xhtml BMJ Open Page 2 of 39 1 2 3 4 BMJ Open: first published as 10.1136/bmjopen-2020-042953 on 25 February 2021. 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Where the Submitting Author wishes to make the Work available on an Open Access basis (and 21 intends to pay the relevant APC), the terms of reuse of such Open Access shall be governed by a Creative 22 Commons licence – details of these licences and which Creative Commons licence will apply to this Work are set 23 out in our licence referred to above. 24 25 Other than as permitted in any relevant BMJ Author’s Self Archiving Policies, I confirm this Work has not been 26 accepted for publication elsewhere, is not being considered for publication elsewhere and does not duplicate 27 material already published. I confirm all authors consent to publication of this Work and authorise the granting 28 of this licence. 29 30 31 32 33 34 35 36 37 38 http://bmjopen.bmj.com/ 39 40 41 42 43 44 45 46 on October 1, 2021 by guest. Protected copyright. 47 48 49 50 51 52 53 54 55 56 57 58 59 60 For peer review only - http://bmjopen.bmj.com/site/about/guidelines.xhtml Page 3 of 39 BMJ Open 1 2 3 4 Additional Treatments to the Local tumour for metastatic BMJ Open: first published as 10.1136/bmjopen-2020-042953 on 25 February 2021. Downloaded from 5 6 prostate cancer: Assessment of Novel Treatment 7 8 Algorithms, a multicentre, phase II randomised controlled 9 10 11 trial (IP2-ATLANTA) 12 13 14 Martin J. Connor [1,2,3], Taimur T Shah [1], Kasia Smigielska [1,4], Emily Day [1,4], 15 16 Johanna Sukumar [1, 4], Francesca Fiorentino [1,4], Naveed Sarwar [5], Michael 17 18 Gonzalez [5], AlisonFor Falconer peer [5], Natalia review Klimowska-Nassar only [1, 4], Martin Evans [1, 19 4], Olivia Frances Naismith [6], Kamalram Thippu Jayaprakash [7], Derek Price [1], 20 21 Shiva Gayadeen [5], Dolan Basak [5], Gail Horan [7], John McGrath [8], Denise 22 23 Sheehan [8], Manal Kumar [9], Azman Ibrahim [10], Cathryn Brock [11], Rachel A. 24 25 Pearson [12], Nicola Anyamene [13], Catherine Heath [14], Iqbal Shergill [15], Bhavan 26 Rai [12], Giles Hellawell [13], Stewart McCracken [16], Bijan Khoubehi [11], Stephen 27 28 Mangar [5], Vincent Khoo [17], Tim Dudderidge [14], John Nicholas Staffurth [18], 29 30 Mathias Winkler [1,2,3], Hashim U. Ahmed [1,2] 31 32 33 1. Division of Surgery, Imperial Prostate, Department of Surgery and Cancer, 34 35 Faculty of Medicine, Imperial College London, London, UB1 3HW 36 37 2. Imperial Urology, Imperial College Healthcare NHS Trust, London, W6 8RF 38 3. Department of Urology, West Middlesex University Hospital (WMUH), Chelsea http://bmjopen.bmj.com/ 39 40 & Westminster NHS Foundation Trust, Isleworth, Middlesex, TW7 6AF 41 42 4. Imperial Clinical Trials Unit (ICTU), School of Public Health, Faculty of Medicine, 43 44 Imperial College London, London,
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