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Persistent Organic Pollutants in Food: Contamination Sources, Health Effects and Detection Methods

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Persistent Organic Pollutants in Food: Contamination Sources, Health Effects and Detection Methods International Journal of Environmental Research and Public Health Review Persistent Organic Pollutants in Food: Contamination Sources, Health Effects and Detection Methods Wenjing Guo, Bohu Pan, Sugunadevi Sakkiah, Gokhan Yavas, Weigong Ge, Wen Zou, Weida Tong and Huixiao Hong * U.S. Food & Drug Administration, National Center for Toxicological Research, 3900 NCTR Road, Jefferson, AR 72079, USA; [email protected] (W.G.); [email protected] (B.P.); [email protected] (S.S.); [email protected] (G.Y.); [email protected] (W.G.); [email protected] (W.Z.); [email protected] (W.T.) * Correspondence: [email protected]; Tel.: +1-870-543-7296 Received: 1 October 2019; Accepted: 5 November 2019; Published: 8 November 2019 Abstract: Persistent organic pollutants (POPs) present in foods have been a major concern for food safety due to their persistence and toxic effects. To ensure food safety and protect human health from POPs, it is critical to achieve a better understanding of POP pathways into food and develop strategies to reduce human exposure. POPs could present in food in the raw stages, transferred from the environment or artificially introduced during food preparation steps. Exposure to these pollutants may cause various health problems such as endocrine disruption, cardiovascular diseases, cancers, diabetes, birth defects, and dysfunctional immune and reproductive systems. This review describes potential sources of POP food contamination, analytical approaches to measure POP levels in food and efforts to control food contamination with POPs. Keywords: persistent organic pollutants; food contamination; human health; food safety; environmental contaminants 1. Introduction Chemical contaminants have become a concern in terms of food safety due to pesticide residue and environmental contaminants detected in the food supply. A large amount of pollutants generated from rapidly developing agricultural and industrial sectors have been released to the environment and found their way into the food supply. Given the widespread occurrence of chemical contaminants in foodstuff and their serious health risks, the prevention of food contamination is a public health priority. In recent decades, there has been a focus on a subset of harmful organic chemicals, mostly of anthropogenic origin, that are commonly classified as persistent organic pollutants (POPs) [1–6]. POPs are a class of carbon-based organic chemicals that are persistent, bioaccumulative and have long-range transport potential. There are three types of POPs present in the environment: (1) pesticides, especially organochlorine pesticides (OCPs) such as dichlorodiphenyltrichloroethane (DDT) and its metabolites; (2) industrial and technical chemicals including polychlorinated biphenyls (PCBs), polybrominated diphenyl ethers (PBDEs), and perfluorooctanesulfonate (PFOS); and (3) by-products of industrial processes including polychlorinated dibenzo-p-dioxins (PCDDs), polychlorinated dibenzofurans (PCDFs), and polyaromatic hydrocarbons (PAHs) [2]. PAHs do not strictly belong to POPs and they are only recognized as POPs under the Aarhus Protocol [7] because they can be efficiently metabolized and, therefore, prevent further bioaccumulation [8,9]. However, due to their lipophilicity and continuous release, PAHs are frequently classified as POPs in many studies [1,4,10–12]. Therefore, in this review, PAHs are discussed together with other POPs. Some commonly found POPs in food are listed in Table1. Int. J. Environ. Res. Public Health 2019, 16, 4361; doi:10.3390/ijerph16224361 www.mdpi.com/journal/ijerph Int. J. Environ. Res. Public Health 2019, 16, x 2 of 32 PAHs are discussed together with other POPs. Some commonly found POPs in food are listed in Table 1. Int. J. Environ. Res. Public Health 2019, 16, x 2 of 32 Table 1. Commonly found persistent organic pollutants (POPs) in food. PAHsInt. J. Environ. are discussed Res. Public Healthtogether 2019 , with16, x other POPs. Some commonly found POPs in food are listed2 of in 32 TablePOPs 1. Class POPs Structure Reference Int.PAHs J. Environ. are discussedRes. Public Health together 2019, 16with, x other POPs. Some commonly found POPs in food are listed2 of 32in Table 1. Table 1. Commonly found persistent organic pollutants (POPs) in food. PAHs are discussed2,3,7,8-tetraCDD; together with 1,2,3,7,8-pentaCDD;other POPs. Some commonly found POPs in food are listed in Chlorodibenzo Table 1. Commonly found persistent organic pollutants (POPs) in food. Int.Table J. Environ. 1. Res. Public Health1,2,3,4,7,8-hexaCDD; 2019, 16, x 1,2,3,6,7,8- 2 of 32 POPs-p- dioxin Class POPs Structure Reference[13–20] hexaCDD; 1,2,3,7,8,9-hexaCDD; (CDD) PAHsPOPs areClass discussed Table1,2,3,4,6,7,8-heptaCDD; together 1. Commonly withPOPs other found POPs. persistent octaCDD Some organi commonlyc pollutants foundStructure (POPs) POPs in food. in food areReference listed in TableInt. J. Environ. 1. Res. Public Health 2019, 16, x 2 of 32 2,3,7,8-tetraCDD; 1,2,3,7,8-pentaCDD; Chlorodibenzo POPs Class 1,2,3,4,7,8-hexaCDD;POPs 1,2,3,6,7,8- Structure Reference PAHs-p- dioxin are discussedTable2,3,7,8-tetraCDD; together 1. Commonly with 1,2,3,7,8-pentaCDD;foundother persistentPOPs. Some organi commonly c pollutants found (POPs) POPs in food. in food are[13–20] listed in Chlorodibenzo 2,3,7,8-tetraCDF;hexaCDD; 1,2,3,7,8,9-hexaCDD; 1,2,3,7,8-pentaCDF; Table(CDD) 1. 1,2,3,4,7,8-hexaCDD; 1,2,3,6,7,8- -p- dioxin 1,2,3,4,6,7,8-heptaCDD;2,3,4,7,8-pentaCDF; 1,2,3,4,7,8- octaCDD [13–20] Int. J. Environ. Res. PublicChlorodibenzoPOPs Health Class2019 , 162,3,7,8-tetraCDD;, 4361hexaCDD;hexaCDF; 1,2,3,6,7,8-hexaCDF;1,2,3,7,8,9-hexaCDD;POPs 1,2,3,7,8-pentaCDD; Structure Reference 2 of 29 Chlorodibenzo(CDD) Table 1. Commonly found persistent organic pollutants (POPs) in food. [13,14,16–20] furan (CDF) 1,2,3,4,6,7,8-heptaCDD;1,2,3,4,7,8-hexaCDD;2,3,4,6,7,8-hexaCDF; 1,2,3,7,8,9-1,2,3,6,7,8- octaCDD -p- dioxin [13–20] 2,3,7,8-tetraCDF;hexaCDF;hexaCDD; 1,2,3,4,6,7,8-heptaCDF; 1,2,3,7,8,9-hexaCDD; 1,2,3,7,8-pentaCDF; POPs(CDD) Class 2,3,7,8-tetraCDD;POPs 1,2,3,7,8-pentaCDD; Structure Reference ChlorodibenzoTable 1. Commonly1,2,3,4,6,7,8-heptaCDD;1,2,3,4,7,8,9-heptaCDF;2,3,4,7,8-pentaCDF; found persistent 1,2,3,4,7,8- organic octaCDDoctaCDF pollutants (POPs) in food. 2,3,7,8-tetraCDF;1,2,3,4,7,8-hexaCDD; 1,2,3,7,8-pentaCDF; 1,2,3,6,7,8- Chlorodibenzo-p- dioxin hexaCDF; 1,2,3,6,7,8-hexaCDF; [13–20] POPs Class2,3,4,7,8-pentaCDF; POPs 1,2,3,4,7,8- Structure[13,14,16–20] Reference furan (CDF) hexaCDD;2,3,4,6,7,8-hexaCDF; 1,2,3,7,8,9-hexaCDD; 1,2,3,7,8,9- Chlorodibenzo(CDD) 2,3,7,8-tetraCDD;hexaCDF; 1,2,3,6,7,8-hexaCDF; 1,2,3,7,8-pentaCDD; Chlorodibenzo PCB-28;2,3,7,8-tetraCDF;1,2,3,4,6,7,8-heptaCDD;hexaCDF;2,3,7,8-tetraCDD; PCB-52; 1,2,3,4,6,7,8-heptaCDF; PC 1,2,3,7,8-pentaCDF; 1,2,3,7,8-pentaCDD;B-70; PCB-77; octaCDD PCB- [13,14,16–20] furan (CDF) 1,2,3,4,7,8-hexaCDD;1,2,3,4,7,8-hexaCDD;2,3,4,6,7,8-hexaCDF; 1,2,3,6,7,8-hexaCDD; 1,2,3,7,8,9-1,2,3,6,7,8- Chlorodibenzo-p-Polychlorinate dioxin-p- dioxin (CDD) 81;1,2,3,4,7,8,9-heptaCDF; 2,3,4,7,8-pentaCDF;PCB-101; PCB-105; PCB-114; 1,2,3,4,7,8- octaCDF PCB- [13[13–20]–20] hexaCDD;1,2,3,7,8,9-hexaCDD; 1,2,3,7,8,9-hexaCDD; Chlorodibenzod biphenyls 118;hexaCDF;hexaCDF; PCB-123; 1,2,3,4,6,7,8-heptaCDF; PCB-126;1,2,3,6,7,8-hexaCDF; PCB-138; PCB- [13,15,16,18–24] (CDD) 1,2,3,4,6,7,8-heptaCDD; octaCDD [13,14,16–20] furan(PCBs) (CDF) 153;2,3,7,8-tetraCDF;1,2,3,4,6,7,8-heptaCDD;1,2,3,4,7,8,9-heptaCDF;2,3,4,6,7,8-hexaCDF; PCB-156; PCB-157; 1,2,3,7,8-pentaCDF; PCB-167; 1,2,3,7,8,9- octaCDFoctaCDD PCB- PCB-28;hexaCDF;169;2,3,7,8-tetraCDF;2,3,4,7,8-pentaCDF; PCB-170;PCB-52; 1,2,3,4,6,7,8-heptaCDF; PC PCB-180; 1,2,3,7,8-pentaCDF;B-70; 1,2,3,4,7,8- PCB-77; PCB-189 PCB- 2,3,4,7,8-pentaCDF; 1,2,3,4,7,8-hexaCDF; ChlorodibenzoPolychlorinate 81;1,2,3,4,7,8,9-heptaCDF; hexaCDF;PCB-101; PCB-105; 1,2,3,6,7,8-hexaCDF; PCB-114; octaCDF PCB- Chlorodibenzo furan (CDF) PCB-28;2,3,7,8-tetraCDF;1,2,3,6,7,8-hexaCDF; PCB-52; PC 1,2,3,7,8-pentaCDF;B-70; 2,3,4,6,7,8-hexaCDF; PCB-77; PCB- [13,14,16–20][13,14,16–20] furand biphenyls (CDF) 118;1,2,3,7,8,9-hexaCDF;2,3,4,6,7,8-hexaCDF; PCB-123; PCB-126; 1,2,3,4,6,7,8-heptaCDF; PCB-138; 1,2,3,7,8,9- PCB- [13,15,16,18–24] Polychlorinate 81; PCB-101;2,3,4,7,8-pentaCDF; PCB-105; PCB-114; 1,2,3,4,7,8- PCB- PolybrominateInt.(PCBs) J.
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