DOCSLIB.ORG

This Works My Wrinkles CBD Booster 004417

Total Page：16

File Type：pdf, Size：1020Kb

Download full-text PDF Read full-text
This Works My Wrinkles CBD Booster 004417 Laboratory Test Report Report Number: R-2020-753-724 Page 1 of 1 Prepared for: This Works Products Ltd Address: 53 St Georges Road Wimbledon SW19 4EA Customer Sample Description: My Wrinkles CBD Booster + Bakuchiol GWOR648/GWOR649 004417 Eurofins Registration Number: 7500 / 2020-753-724 No. of samples: 1 Test(s) Performed: Cannabinoid Quantification and Density measurement for CBD profiling Date Received: 21/02/2020 Date(s) Tested: 24/02/2020 – 28/02/2020 Results and Observations Please refer to the following page(s) _________________ Christine Dee (Analytical Services Manager) Date: 04/03/2020 The reported results relate exclusively to the tested sample. The testing was performed by a laboratory within the Eurofins Group. Eurofins Product Testing Services Limited Registered Office: Unit 16, Willan Trading Estate, Waverley Road i54 Business Park, Valiant Way Sale, M33 7AY Wolverhampton, WV9 5GB Tel: +44 (0)161 868 7600 Registration Number: 7401660 Fax: +44 (0)161 868 7699 Vat Number: 887 1276 83 Report Number: 2803666-0 Report Date: 04-Mar-2020 Report Status: Final Certificate of Analysis Eurofins Product Testing Services Limited UNIT 16, WILLAN TRADING ESTATE, WAVERLEY ROAD Sale M33 7AY Sample Name: My Wrinkles CBD Booster Plus Eurofins Sample: 9302398 Bakuchiol Project ID EURO_HAR-20200224-0033 Receipt Date 24-Feb-2020 PO Number CVD Receipt Condition Ambient temperature Lot Number 2020-753-724 Login Date 24-Feb-2020 Sample Serving Size Date Started 28-Feb-2020 Sampled Sample results apply as received Online Order 20 Analysis Result Specific Gravity * Density 0.961 g/mL Industrial Hemp Cannabinoid Profile * CBDVA <0.00250 % CBDV <0.00250 % CBDA <0.00250 % CBGA <0.00250 % CBG <0.00250 % CBD 0.954 % THCV <0.00250 % CBN <0.00250 % Delta 9-THC <0.00250 % Delta 8-THC <0.00500 % THCA <0.00250 % CBC <0.00250 % Total Cannabinoids 0.954 % Total THC (THC + (THCA x 0.877)) <0.00500 % Total CBD (CBD + (CBDA x 0.877)) 0.954 % Method References Testing Location Industrial Hemp Cannabinoid Profile (IHCBD_S) Food Integrity Innovation-Harrogate Otley Road Harrogate, North Yorkshire, United Kingdom HG3 1PY GBR Official Methods of Analysis, Method 2018.11, AOAC INTERNATIONAL, (Modified). Lukas Vaclavik, Frantisek Benes, Alex Krmela, Veronika Svobodova, Jana Hajsolva and Katerina Mastovska, "Quantification of Cannabinoids in Cannabis Dried Plant Materials, Concentrates, and Oils Liquid Chromatography-Diode Array Detection Technique with Optional Mass Spectrometric Detection, " First Action Method, Journal of AOAC International, Future Issue Specific Gravity (SPGP_S) Food Integrity Innovation-Harrogate Otley Road Harrogate, North Yorkshire, United Kingdom HG3 1PY GBR NIST Handbook 133 - Checking the Net Contents of Packaged Goods, 2015 Edition (Modified) * This analysis or component is not ISO accredited. Printed: 04-Mar-2020 4:31 am Page 1 of 2 Report Number: 2803666-0 Report Date: 04-Mar-2020 Report Status: Final Certificate of Analysis Eurofins Product Testing Services Limited UNIT 16, WILLAN TRADING ESTATE, WAVERLEY ROAD Sale M33 7AY Testing Location(s) Released on Behalf of Eurofins by Food Integrity Innovation-Harrogate Christopher Houlton - Director Eurofins Food Integrity Testing UK Limited Otley Road Harrogate North Yorkshire, United Kingdom HG3 1PY +44 0 1423 635864 These results apply only to the items tested. This certificate of analysis shall not be reproduced, except in its entirety, without the written approval of Eurofins. * This analysis or component is not ISO accredited. Printed: 04-Mar-2020 4:31 am Page 2 of 2 Analytical Report Fraser Fergie This Works Products Ltd 53 St Georges Road Wimbledon London SW19 4EA United Kingdom Date of sample receipt: 10 July 2020 Report issue date: 28 July 2020 Sample Type: Customer Reference: Cannabinoid product TW030026 TW030027 TW030028 TW030029 TW030030 Signed: Stephen Chapman, Senior Analyst [email protected] This report has been prepared by FERA after exercise of all reasonable care and skill, but is provided without liability in its application and use. This report may not be reproduced except in full, without the written approval of FERA. Samples will be disposed of ten working days after the issue date of this report and data and associated paperwork after two years, unless requested otherwise by the customer. Fera Science Ltd., Tel +44 (0) 300 100 0323 Report Reference: R20-52036 York Biotech Campus, Email: [email protected] Page 1 of 7 Sand Hutton, Web: www.fera.co.uk York, YO41 1LZ Analytical Report Report Details: Method Summary: Mycotoxins were extracted from the samples into organic solvents. Extracts were centrifuged, filtered and cleaned-up using immunoaffinity columns. Quantification was by HPLC with fluorescence detection for ochratoxin A and aflatoxins B1, B2, G1 and G2 (with post column derivatisation). (FSG261) Report Summary: Recovery values determined for control samples spiked at 2.5 µg/kg for aflatoxins B1, B2, G1 and G2 and ochratoxin A. Results quoted in this report are corrected for recovery. Fera Science Ltd., Tel +44 (0) 300 100 0323 Report Reference: R20-52036 York Biotech Campus, Email: [email protected] Page 2 of 7 Sand Hutton, Web: www.fera.co.uk York, YO41 1LZ Analytical Report Sample Details: FERA Reference: S20-033102 Sample received on: 10 Jul 2020 Sample Type: Cannabinoid product Customer Reference: TW030029 Lot Code: 004417 Additional Information: My Wrinkles CBD booster + Bakuchiol Analytical results: Result Recovery % acrylamide µg/kg aflatoxin B1 (AFB1) < 0.2 µg/kg 102 aflatoxin B2 (AFB2) < 0.2 µg/kg 107 aflatoxin G1 (AFG1) < 0.2 µg/kg 93 aflatoxin G2 (AFG2) < 0.2 µg/kg 93 ochratoxin A (OA) < 0.2 µg/kg 105 Total aflatoxin < 0.8 µg/kg Fera Science Ltd., Tel +44 (0) 300 100 0323 Report Reference: R20-52036 York Biotech Campus, Email: [email protected] Page 5 of 7 Sand Hutton, Web: www.fera.co.uk York, YO41 1LZ Analytical Report Fraser Fergie This Works Products Ltd 53 St Georges Road Wimbledon London SW19 4EA United Kingdom Customer reference: W5ZE 0785 Date of sample receipt: 10 July 2020 Report issue date: 24 July 2020 Sample Type: Customer Reference: Cannabinoid product TW030026 TW030027 TW030028 TW030029 TW030030 Signed: Mike Walls, Senior Analyst Malcolm Baxter, Senior Analyst [email protected] [email protected] This report has been prepared by FERA after exercise of all reasonable care and skill, but is provided without liability in its application and use. This report may not be reproduced except in full, without the written approval of FERA. Samples will be disposed of ten working days after the issue date of this report unless requested otherwise by the customer. Fera Science Ltd., Tel +44 (0) 300 100 0323 Report Reference: R20-52003 (This Works) York Biotech Campus, Email: [email protected] Page 1 of 7 Sand Hutton, Web: www.fera.co.uk York, YO41 1LZ Analytical Report Report Details: Method Summary: FSG 461: Totals method (Batch AZS) Aliquots of homogenised test sample were digested in a mixture of nitric acid and hydrochloric acid using a high pressure microwave system. Quantification was by inductively coupled plasma-mass spectrometry (ICP-MS) with collision cell. Quality checks included blanks, spikes and certified reference materials. Report Summary: All data are corrected for reagent blank and spike recovery. The Reporting Limit was calculated from 10 x standard deviation of reagent blank values adjusted for dilution and sample weight. Reference material data were satisfactory. < denotes result is less than the Reporting Limit Fera Science Ltd., Tel +44 (0) 300 100 0323 Report Reference: R20-52003 (This Works) York Biotech Campus, Email: [email protected] Page 2 of 7 Sand Hutton, Web: www.fera.co.uk York, YO41 1LZ Analytical Report Sample Details: FERA Reference: S20-033102 Sample received on: 10 Jul 2020 Sample Type: Cannabinoid product Customer Reference: TW030029 Lot Code: 004417 Additional Information: My Wrinkles CBD booster + Bakuchiol Analytical results: Result Recovery Batch Reporting % Code Limit Antimony < 0.005 mg/kg 100 AZS 0.005 mg/kg Arsenic < 0.01 mg/kg 103 AZS 0.01 mg/kg Cadmium < 0.005 mg/kg 107 AZS 0.005 mg/kg Chromium < 0.1 mg/kg 105 AZS 0.1 mg/kg Copper < 0.10 mg/kg 100 AZS 0.1 mg/kg Lead < 0.01 mg/kg 109 AZS 0.01 mg/kg Mercury < 0.01 mg/kg 100 AZS 0.01 mg/kg Nickel < 0.1 mg/kg 101 AZS 0.1 mg/kg Zinc < 0.1 mg/kg 100 AZS 0.1 mg/kg Fera Science Ltd., Tel +44 (0) 300 100 0323 Report Reference: R20-52003 (This Works) York Biotech Campus, Email: [email protected] Page 5 of 7 Sand Hutton, Web: www.fera.co.uk York, YO41 1LZ Final Analytical Report Fraser Fergie This Works Products Ltd 53 St Georges Road Wimbledon London SW19 4EA United Kingdom Date of sample receipt: 10 July 2020 Report issue date: 27 July 2020 Sample Type: Customer Reference: Cannabinoid product TW030026 TW030027 TW030028 TW030029 TW030030 Test Details: GCMS-MRM (FV) (SOP: FSG/167 (07) GCMS) LCMS-MRM (FV) (SOP: FSG/167 (07) LCMS) Signed: Stephen Holmes, Analytical Chemist [email protected] This report has been prepared by FERA after exercise of all reasonable care and skill, but is provided without liability in its application and use. This report may not be reproduced except in full, without the written approval of FERA. Fera Science Ltd., Tel +44 (0) 300 100 0323 Report Reference: R20-52017 York Biotech Campus, Email: [email protected] Page 1 of 70 Sand Hutton, Web: www.fera.co.uk York, YO41 1LZ Final Analytical Report Report Details: Method Summary: No deviations from the SOP were made. Report Summary: No residues were found in the sample(s) supplied at or above the reporting limits quoted. Where there is no recovery the analysis was performed by standard addition.
Load more

Recommended publications
  • California Essential Drug List
    California Essential Drug List The Essential Drug List (formulary) includes a list of drugs covered by Health Net. The drug list is updated at least monthly and is subject to change. All previous versions are no longer in effect. You can view the most current drug list by going to our website at www.healthnet.com. Refer to Evidence of Coverage or Certificate of Insurance for specific cost share information. For California Individual & Family Plans: Drug Lists Select Health Net Large Group – Formulary (pdf). For Small Business Group: Drug Lists Select Health Net Small Business Group – Formulary (pdf). NOTE: To search the drug list online, open the (pdf) document. Hold down the “Control” (Ctrl) and “F” keys. When the search box appears, type the name of your drug and press the “Enter” key. If you have questions or need more information call us toll free. California Individual & Family Plans (off-Exchange) If you have questions about your pharmacy coverage call Customer Service at 1-800-839-2172 California Individual & Family Plans (on-Exchange) If you have questions about your pharmacy coverage call Customer Service at 1-888-926-4988 Hours of Operation 8:00am – 7:00pm Monday through Friday 8:00am – 5:00pm Saturday Small Business Group If you have questions about your pharmacy coverage call Customer Service at 1-800-361-3366 Hours of Operation 8:00am – 6:00pm Monday through Friday Updated September 1, 2021 Health Net of California, Inc. and Health Net Life Insurance Company are subsidiaries of Health Net, LLC and Centene Corporation. Health Net is a registered service mark of Health Net, LLC Table of Contents What If I Have Questions Regarding My Pharmacy Benefit? ...................................
    [Show full text]
  • (12) United States Patent (10) Patent No.: US 9,713,596 B2 Hong Et Al
    USOO9713596B2 (12) United States Patent (10) Patent No.: US 9,713,596 B2 Hong et al. (45) Date of Patent: Jul. 25, 2017 (54) BAKUCHOL COMPOSITIONS FOR FOREIGN PATENT DOCUMENTS TREATMENT OF POST INFLAMMATORY DE 1900 435 7, 1970 HYPERPGMENTATION DE 3417234 A1 * 11, 1985 JP H1171231 A * 3, 1999 ............... A61K 7.00 (75) Inventors: Mei Feng Hong, Lacey, WA (US); Qi JP 2000-327581 A 11 2000 Jia, Olympia, WA (US); Lidia Alfaro JP 2005325 120 A 11/2005 KR 2000-0007648 A 2, 2000 Brownell, Tacoma, WA (US) WO 2006/122160 A2 11/2006 WO 2008. 140673 A1 11, 2008 (73) Assignee: Unigen, Inc., Lacey, WA (US) (*) Notice: Subject to any disclaimer, the term of this OTHER PUBLICATIONS patent is extended or adjusted under 35 Ohno, O. Watabe, T., Kazuhiko, N., Kawagoshi, M., Uotsu, N., U.S.C. 154(b) by 0 days. Chiba, T., Yamada, M., Yamaguchi, K., Yamada, K., Miyamoto, K., Uemura, D. Inhibitory Effects of Bakuchiol, Bavachin, an (21) Appl. No.: 13/365,172 Isobavachalcone Isolated from Piper loungum on Melainin Produc (22) Filed: Feb. 2, 2012 tion in B 16 Mouse Melanoma Cells. Biosci. Biotechnol. Biochem. 74 (7), 1504-1506 (2010).* Prior Publication Data Hiroyuki Haraguchi, Junji Inoue, Yukiyoshi Tamura and Kenji (65) Mizutani.Antioxidative Components of Psoralea corylifolia US 2012/O2O1769 A1 Aug. 9, 2012 (Leguminosae). Phytother. Res. 16, 539-544 (2002).* Petra Clara Arck, et al. Towards a “free radical theory of graying: melanocyte apoptosis in the aging human hair follicle is an indicator Related U.S. Application Data of oxidative stress induced tissue damage.
    [Show full text]
  • Next Generation Risk Assessment of Human Exposure to Anti-Androgens Using Newly Defined Comparator Compound Values
    Toxicology in Vitro 73 (2021) 105132 Contents lists available at ScienceDirect Toxicology in Vitro journal homepage: www.elsevier.com/locate/toxinvit Next generation risk assessment of human exposure to anti-androgens using newly defined comparator compound values Tessa C.A. van Tongeren a,*, Thomas E. Moxon b, Matthew P. Dent b, Hequn Li b, Paul L. Carmichael b, Ivonne M.C.M. Rietjens a a Division of Toxicology, Wageningen University and Research, 6700, EA, Wageningen, the Netherlands b Unilever Safety and Environmental Assurance Centre, Colworth Science Park, Sharnbrook, Bedfordshire MK44 1LQ, UK ARTICLE INFO ABSTRACT Keywords: Next Generation Risk Assessment (NGRA) can use the so-called Dietary Comparator Ratio (DCR) to evaluate the Risk assessment safety of a definedexposure to a compound of interest. The DCR compares the Exposure Activity Ratio (EAR) for 3R compliant method the compound of interest, to the EAR of an established safe level of human exposure to a comparator compound Androgen receptor with the same putative mode of action. A DCR ≤ 1 indicates the exposure evaluated is safe. The present study Dietary comparator aimed at defining adequate and safe comparator compound exposures for evaluation of anti-androgenic effects, In vitro/in silico approaches using 3,3-diindolylmethane (DIM), from cruciferous vegetables, and the anti-androgenic drug bicalutamide (BIC). EAR values for these comparator compounds were definedusing the AR-CALUX assay. The adequacy of the new comparator EAR values was evaluated using PBK modelling and by comparing the generated DCRs of a series of test compound exposures to actual knowledge on their safety regarding in vivo anti-androgenicity.
    [Show full text]
  • 2021 Drug Formulary | Kaiser Permanente Washington
    Effective October 2021 2021 Drug Formulary For members covered through large employer groups with a 3-tier in-network pharmacy benefit or members with an out-of-network pharmacy benefit Tip: To bring up the search box and search by drug name: PC: Control + F | Mac: Command + F Access PPO Alliance Alliant Plus Core Elect PPO Omni PPO Options PPO All plans offered and underwritten by Kaiser Foundation Health Plan of Washington or Kaiser Foundation Health Plan of Washington Options, Inc. XB0001338-50-17 Drug Formulary INTRODUCTION What is a formulary? A formulary is a list of generic, brand, and specialty drugs. It is used by practitioners to identify drugs that offer the best overall value, considering effectiveness, safety, and cost. How is the drug formulary developed? The formulary is developed by the Kaiser Permanente Pharmacy and Therapeutics (P&T) Committee. The P&T Committee is composed of physicians from various medical specialties, pharmacists, and a consumer member. The P&T Committee reviews and selects the most appropriate drugs in each class for the formulary based on safety, effectiveness, and cost. The P&T Committee meets quarterly to review new and existing drugs to ensure that the formulary remains responsive to the needs of members and providers. How do I search the formulary? Drugs on the formulary are listed by therapeutic class. An alphabetical index is included at the end of this document to assist in locating specific drugs. Drugs are listed by generic name if a generic is available. If there is no generic available, drugs are listed by the brand name.
    [Show full text]
  • Analytical Reference Standards
    Cerilliant Quality ISO GUIDE 34 ISO/IEC 17025 ISO 90 01:2 00 8 GM P/ GL P Analytical Reference Standards 2 011 Analytical Reference Standards 20 811 PALOMA DRIVE, SUITE A, ROUND ROCK, TEXAS 78665, USA 11 PHONE 800/848-7837 | 512/238-9974 | FAX 800/654-1458 | 512/238-9129 | www.cerilliant.com company overview about cerilliant Cerilliant is an ISO Guide 34 and ISO 17025 accredited company dedicated to producing and providing high quality Certified Reference Standards and Certified Spiking SolutionsTM. We serve a diverse group of customers including private and public laboratories, research institutes, instrument manufacturers and pharmaceutical concerns – organizations that require materials of the highest quality, whether they’re conducing clinical or forensic testing, environmental analysis, pharmaceutical research, or developing new testing equipment. But we do more than just conduct science on their behalf. We make science smarter. Our team of experts includes numerous PhDs and advance-degreed specialists in science, manufacturing, and quality control, all of whom have a passion for the work they do, thrive in our collaborative atmosphere which values innovative thinking, and approach each day committed to delivering products and service second to none. At Cerilliant, we believe good chemistry is more than just a process in the lab. It’s also about creating partnerships that anticipate the needs of our clients and provide the catalyst for their success. to place an order or for customer service WEBSITE: www.cerilliant.com E-MAIL: [email protected] PHONE (8 A.M.–5 P.M. CT): 800/848-7837 | 512/238-9974 FAX: 800/654-1458 | 512/238-9129 ADDRESS: 811 PALOMA DRIVE, SUITE A ROUND ROCK, TEXAS 78665, USA © 2010 Cerilliant Corporation.
    [Show full text]
  • August 2021 California Signaturevalue 4 Tier HMO Formulary
    Pharmacy | Formulary | California 2021 California SignatureValue 4-Tier HMO Formulary Please note: This Formulary is accurate as of August 1, 2021 and is subject to change after this date. All previous versions of this Formulary are no longer in effect. Your estimated coverage and copay/coinsurance may vary based on the benefit plan you choose and the effective date of the plan. This Formulary can also be accessed online at myuhc.com > Pharmacy Information > Prescription Drug Lists > California plans > SignatureValue HMO plans. Plan-specific coverage documents may be accessed online at uhc.com/statedruglists > Small Group Plans > California. If you are a UnitedHealthcare member, please register or log on to myuhc.com, or call the toll-free number on your health plan ID card to find pharmacy information specific to your benefit plan. This Formulary is applicable to the following health insurance products offered by UnitedHealthcare: • SignatureValue • SignatureValue Advantage • SignatureValue Alliance • SignatureValue Flex • SignatureValue Focus • SignatureValue Harmony • SignatureValue Performance Updated 6/17/2021 6/21 © 2021 United HealthCare Services, Inc. All Rights Reserved. WF3890815-N Contents At UnitedHealthcare, we want to help you better understand your medication options. ..................................................... 3 How do I use my Formulary? ............................................. 4 What are tiers? ........................................................ 5 When does the Formulary change? ........................................ 5 Utilization Management Programs ......................................... 6 Your Right to Request Access to a Non-formulary Drug ....................... 6 Requesting a Prior Authorization or Step Therapy Exception ................... 7 How do I locate and fill a prescription through a retail network pharmacy? . 7 How do I locate and fill a prescription through the mail order pharmacy? . 7 How do I locate and fill a prescription at a specialty pharmacy? ...............
    [Show full text]
  • WA Essential Drug List Updated: July 1, 2020
    Washington Essential Rx Drug List The Essential Rx Drug List includes a list of drugs covered by Health Net. This drug list is for Washington. The drug list is updated often and may change. To get the most up-to-date information, you may view the latest drug list on our website at www.healthnet.com/wadruglistpdf or call us at the toll-free telephone number on your Health Net ID card. WA Essential Drug List Updated: July 1, 2020 Welcome to Health Net What is the Essential Rx Drug List? The Essential Rx Drug List or formulary is a list of covered drugs used to treat common diseases or health problems. The drug list is selected by a committee of doctors and pharmacists who meet regularly to decide which drugs should be included. The committee reviews new drugs and new information about existing drugs and chooses drugs based on: • Safety; • Effectiveness; • Side effects; and • Value (If two drugs are equally effective, the less costly drug will be preferred) How much will I pay for my drugs? To figure out how much you will pay for a drug, the abbreviations in the table below appear in the Drug Tier column on the formulary. The copayment or coinsurance levels are defined in the table below. If you do not know your copayment or coinsurance for each tier, please refer to your Summary of Benefits or other plan documents. Abbreviation Copayment/Coinsurance Description 1 Tier 1 copayment or Generic drugs coinsurance 2 Tier 2 copayment or Preferred brand drugs coinsurance 3 Tier 3 copayment or Non-preferred brand drugs coinsurance SP Specialty copayment or Specialty drugs.
    [Show full text]
  • A Potential Alternative Against Neurodegenerative Diseases: Phytodrugs
    Hindawi Publishing Corporation Oxidative Medicine and Cellular Longevity Volume 2016, Article ID 8378613, 19 pages http://dx.doi.org/10.1155/2016/8378613 Review Article A Potential Alternative against Neurodegenerative Diseases: Phytodrugs Jesús Pérez-Hernández,1,2 Víctor Javier Zaldívar-Machorro,1,3 David Villanueva-Porras,1,4 Elisa Vega-Ávila,5 and Anahí Chavarría1 1 DepartamentodeMedicinaExperimental,FacultaddeMedicina,UniversidadNacionalAutonoma´ de Mexico,´ 06726 Mexico,´ DF, Mexico 2Posgrado en Biolog´ıa Experimental, Universidad Autonoma´ Metropolitana-Iztapalapa, 09340 Mexico,´ DF, Mexico 3Programa de Becas Posdoctorales, Universidad Nacional Autonoma´ de Mexico,´ 04510 Mexico,´ DF, Mexico 4Posgrado en Ciencias Biomedicas,´ Universidad Nacional Autonoma´ de Mexico,´ 04510 Mexico,´ DF, Mexico 5Division´ de Ciencias Biologicas´ y de la Salud, Universidad Autonoma´ Metropolitana, 09340 Mexico,´ DF, Mexico Correspondence should be addressed to Anah´ıChavarr´ıa; [email protected] Received 3 July 2015; Revised 2 November 2015; Accepted 5 November 2015 AcademicEditor:AnandhB.P.Velayutham Copyright © 2016 Jesus´ Perez-Hern´ andez´ et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Neurodegenerative diseases (ND) primarily affect the neurons in the human brain secondary to oxidative stress and neuroinflam- mation. ND are more common and have a disproportionate impact on countries with longer life expectancies and represent the fourth highest source of overall disease burden in the high-income countries. A large majority of the medicinal plant compounds, such as polyphenols, alkaloids, and terpenes, have therapeutic properties. Polyphenols are the most common active compounds in herbs and vegetables consumed by man.
    [Show full text]
  • WO 2012/177757 A2 27 December 2012 (27.12.2012) P O P C T
    (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (10) International Publication Number (43) International Publication Date WO 2012/177757 A2 27 December 2012 (27.12.2012) P O P C T (51) International Patent Classification: MARAIS, Thomas, Allen [US/US]; 10204 Scull Road, A61K 8/02 (2006.01) A61K 8/92 (2006.01) Cincinnati, Ohio 45252 (US). TANNER, Paul, Robert A61K 8/06 (2006.01) A61Q 19/10 (2006.01) [US/US]; 3325 Golden Fox Trail, Lebanon, Ohio 45036 A61K 8/81 (2006.01) (US). TAO, Binwu [CN/CN]; 306-1-504 Baiziwang Jiay- uan, Beijing, 100022 (CN). (21) International Application Number: PCT/US2012/043344 (74) Common Representative: THE PROCTER & GAMBLE COMPANY; c/o Timothy B. Guffey, Global (22) International Filing Date: Patent Services, 299 East Sixth Street, Sycamore Building, 20 June 2012 (20.06.2012) 4th Floor, Cincinnati, Ohio 45202 (US). (25) Filing Language: English (81) Designated States (unless otherwise indicated, for every (26) Publication Language: English kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, (30) Priority Data: CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, 61/498,918 20 June 201 1 (20.06.201 1) US DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, (71) Applicant (for all designated States except US): THE HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, PROCTER & GAMBLE COMPANY [US/US]; One KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, Procter & Gamble Plaza, Cincinnati, Ohio 45202 (US).
    [Show full text]
  • 10 TNF Blockade: an Inflammatory Issue
    10 TNF Blockade: An Inflammatory Issue B.B. Aggarwal, S. Shishodia, Y. Takada, D. Jackson-Bernitsas, K.S. Ahn, G. Sethi, H. Ichikawa 10.1 Introduction . 162 10.2 TNFCellSignaling.........................162 10.3 InhibitorsofTNFCellSignaling..................166 10.3.1 NF-κBBlockers...........................166 10.3.2AP-1Blockers............................168 10.3.3 Suppression of TNF-Induced P38 MAPK Activation ........168 10.3.4 Suppression of TNF-Induced JNK Activation . 169 10.3.5 Suppression of TNF-Induced P42/p44 MAPK Activation . 170 10.3.6 Suppression of TNF-Induced AKT Activation . 171 10.4 Role of TNF in Skin Diseases ....................172 10.5 BrightSideofTNF.........................174 10.6 DarkSideofTNFBlockers.....................174 10.7 IdentificationofNovelBlockersofTNF..............178 10.8 Conclusions.............................180 References ..................................180 Abstract. Tumor necrosis factor (TNF), initially discovered as a result of its antitumor activity, has now been shown to mediate tumor initiation, promo- tion, and metastasis. In addition, dysregulation of TNF has been implicated in a wide variety of inflammatory diseases including rheumatoid arthritis, Crohn’s disease, multiple sclerosis, psoriasis, scleroderma, atopic dermatitis, systemic lupus erythematosus, type II diabetes, atherosclerosis, myocardial infarction, 162 B.B. Aggarwal et al. osteoporosis, and autoimmune deficiency disease. TNF, however, is a critical component of effective immune surveillance and is required for proper prolifer- ation and function of NK cells, T cells, B cells, macrophages, and dendritic cells. TNF activity can be blocked, either by using antibodies (Remicade and Humira) or soluble TNF receptor (Enbrel), for the symptoms of arthritis and Crohn’s disease to be alleviated, but at the same time, such treatment increases the risk of infections, certain type of cancers, and cardiotoxicity.
    [Show full text]
  • Targeting Inflammatory Pathways by Flavonoids for Prevention and Treatment of Cancer
    1044 Reviews Targeting Inflammatory Pathways by Flavonoids for Prevention and Treatment of Cancer Authors Sahdeo Prasad, Kannokarn Phromnoi, Vivek R. Yadav, Madan M. Chaturvedi, Bharat B. Aggarwal Affiliation Cytokine Research Laboratory, Department of Experimental Therapeutics, The University of Texas, M.D. Anderson Cancer Center, Houston, Texas, USA Key words Abstract formation, tumor cell survival, proliferation, inva- l" cancer ! sion, angiogenesis, and metastasis. Whereas vari- l" inflammation Observational studies have suggested that life- ous lifestyle risk factors have been found to acti- l" flavonoids style risk factors such as tobacco, alcohol, high- vate NF-κB and NF-κB-regulated gene products, l" NF‑κB fat diet, radiation, and infections can cause cancer flavonoids derived from fruits and vegetables l" fruits l" vegetables and that a diet consisting of fruits and vegetables have been found to suppress this pathway. The can prevent cancer. Evidence from our laboratory present review describes various flavones, flava- and others suggests that agents either causing or nones, flavonols, isoflavones, anthocyanins, and preventing cancer are linked through the regula- chalcones derived from fruits, vegetables, le- tion of inflammatory pathways. Genes regulated gumes, spices, and nuts that can suppress the by the transcription factor NF-κB have been proinflammatory cell signaling pathways and shown to mediate inflammation, cellular trans- thus can prevent and even treat the cancer. Introduction cancers and the observed changes in the inci- ! dence of cancer in migrating populations. For ex- Despite spending billions of dollars in research, a ample, Ho [4] showed that although the Chinese great deal of understanding of the causes and cell in Shanghai will have a cancer incidence of 2 cases signaling pathways that lead to the disease, can- per 100 000 population, among those who mi- cer continues to be a major killer worldwide.
    [Show full text]
  • Toxicology Reference Laboratory
    TOXICOLOGY REFERENCE LABORATORY Laboratory User Guide ROOM 708, BLOCK P PRINCESS MARGARET HOSPITAL 2-10 Princess Margaret Hospital Road Lai Chi Kok Tel: 2990 1941 Fax: 2990 1942 http://trl.home Version 6.1 Effective date: 1/July/2014 Contents Contents ..................................................................................................................................................... 2 Introduction ............................................................................................................................................... 4 Staff ............................................................................................................................................................ 5 Honorary Medical Staff .......................................................................................................................... 5 Scientific Staff ........................................................................................................................................ 5 Technical Staff ........................................................................................................................................ 5 Supportive Staff ...................................................................................................................................... 6 How to Make Laboratory Request .......................................................................................................... 7 Instruction for Referring Clinician ........................................................................................................
    [Show full text]