Aviva Systems Biology NFE2 Antibody - C-terminal region (OAAB09862) Product Number OAAB09862 Product Page http://www.avivasysbio.com/nfe2-antibody-c-terminal-region-oaab09862.html Product Name NFE2 Antibody - C-terminal region (OAAB09862) Size 400ul Symbol NFE2 Alias Symbols NFE2, NF-E2 45 kDa subunit, NF-E2, Nuclear factor, erythroid-derived 2 45 kDa subunit, p45 NF-E2 Molecular Weight 41473 Da Product Format Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification. Isotype Ig NCBI Gene Id 4778 Host Rabbit Clonality Polyclonal Concentration Approximately 0.5mg/ml. Actual concentration varies with each lot. Description NFE2 antibody - C-terminal region Description of Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab) Target Reconstitution and Maintain refrigerated at 2-8C for up to 6 months. For long term storage store at -20C in Storage small aliquots to prevent freeze-thaw cycles. Specificity This NFE2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 311-340 amino acids from the C-terminal region of human NFE2. Additional Precautions: NFE2 Antibody (C-term) is for research use only and not for use in Information diagnostic or therapeutic procedures. Additional Function: Component of the NF-E2 complex essential for regulating erythroid and Information megakaryocytic maturation and differentiation. Binds to the hypersensitive site 2 (HS2) of the beta-globin control region (LCR). This subunit (NFE2) recognizes the TCAT/C sequence of the AP-1-like core palindrome present in a number of erythroid and megakaryocytic gene promoters. Requires MAFK or other for binding to the NF-E2 motif. May play a role in all aspects of hemoglobin production from globin and heme synthesis to procurement of iron Application Info WB 1:100 - 500 Lead Time Domestic: within 1 week delivery International: 1 week *** Required Wet/Dry Ice Surcharge will automatically be applied upon checkout for the shipment. See Surcharges Additional Cellular Location: Nucleus, PML body. Cytoplasm. Note=The sumoylated form locates Information to the nuclear bodies PML oncogenic domains (PODs). Translocated to the cytoplasm through interaction with ITCH Tissue Location: Expressed in hematopoietic cells and also in colon and testis Tissue Tool Find tissues and cell lines supported by DNA array analysis to express NFE2. Swissprot Id Q16621

5754 Pacific Center Blvd., Suite 201 San Diego, CA 92121 USA | Tel: (858)552-6979 | [email protected] 1 Protein Name Transcription factor NF-E2 45 kDa subunit Protein Accession NP_001129495.1 # RNA Seq Find tissues and cell lines supported by RNA-seq analysis to express NFE2. Replacement Item This antibody may replace item sc-22827 from Santa Cruz Biotechnology. CB Replacement sc-22827; sc-291; sc-36046; sc-36047; sc-365083; sc-514429 Species Reactivity Human Application WB Predicted Human Homology Based on Immunogen Sequence

Image 1: MDA-MB435 NFE2 Antibody (C-term) (Cat. #OAAB09862) western blot analysis in MDA-MB435 cell line lysates (35ug/lane).This demonstrates the NFE2 antibody detected the NFE2 protein (arrow).

AVIVA SYSTEMS BIOLOGY manufactures and sells quality antibody products covering genome wide proteins. This product is for Research Use Only. Not for diagnostic, human, or veterinary use. Optimal conditions of its use should be determined by end users.

5754 Pacific Center Blvd., Suite 201 San Diego, CA 92121 USA | Tel: (858)552-6979 | [email protected] 2