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MRC Investigators and Directors Directory of Research Programmes at MRC Institutes and Units Foreword
SUMMER 2021 MRC Investigators and Directors Directory of research programmes at MRC Institutes and Units Foreword I am delighted to introduce you to the exceptional To support the MRC Investigators and Directors researchers at our MRC Institutes and Units – the in advancing medical research, MRC provides MRC Investigators and their Directors. core funding to the MRC Institutes and University Units where they carry out their work. These In November 2020, MRC established the new title establishments cover a huge breadth of medical of “MRC Investigator” for Programme Leaders (PL) research from molecular biology to public health. and Programme Leader Track (PLT) researchers at As you will see from the directory, the MRC MRC Institutes and Units. These individuals are Investigators and Directors are making considerable world-class scientists who are either strong leaders advances in their respective fields through their in their field already (PLs) or are making great innovative and exciting research programmes. Their strides towards that goal (PLTs). Based on what accomplishments have been recognised beyond they have achieved in their research careers so far, MRC and many have been awarded notable prizes the title will no doubt become synonymous with and elected to learned societies and organisations. scientific accomplishment, impact and integrity. As well as being widely recognised within the MRC endeavours to do everything it can to support scientific and academic communities, the well- its researchers at all career stages. For this reason, established and newer title of “Director” and we chose not to distinguish between levels of “MRC Investigator”, respectively, are a signal seniority within the new title. -
Nociceptive Interneurons Control Modular Motor Pathways to Promote
RESEARCH ARTICLE Nociceptive interneurons control modular motor pathways to promote escape behavior in Drosophila Anita Burgos1*, Ken Honjo2, Tomoko Ohyama3, Cheng Sam Qian1, Grace Ji-eun Shin4, Daryl M Gohl5, Marion Silies6, W Daniel Tracey7,8, Marta Zlatic9, Albert Cardona9, Wesley B Grueber1,4,10* 1Department of Neuroscience, Columbia University Medical Center, New York, United States; 2Faculty of Life and Environmental Sciences, University of Tsukuba, Tsukuba, Japan; 3Department of Biology, McGill University, Montreal, Canada; 4Department of Physiology and Cellular Biophysics, Columbia University Medical Center, New York, United States; 5University of Minnesota Genomics Center, Minneapolis, United States; 6European Neuroscience Institute Go¨ ttingen, Go¨ ttingen, Germany; 7The Linda and Jack Gill Center for Biomolecular Science, Indiana University, Bloomington, United States; 8Department of Biology, Indiana University, Bloomington, United States; 9Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, United States; 10Mortimer B. Zuckerman Mind Brain Behavior Institute, Columbia University, New York, United States Abstract Rapid and efficient escape behaviors in response to noxious sensory stimuli are essential for protection and survival. Yet, how noxious stimuli are transformed to coordinated escape behaviors remains poorly understood. In Drosophila larvae, noxious stimuli trigger sequential body bending and corkscrew-like rolling behavior. We identified a population of interneurons in the nerve cord of Drosophila, termed Down-and-Back (DnB) neurons, that are *For correspondence: activated by noxious heat, promote nociceptive behavior, and are required for robust escape [email protected] (AB); responses to noxious stimuli. Electron microscopic circuit reconstruction shows that DnBs are [email protected] (WBG) targets of nociceptive and mechanosensory neurons, are directly presynaptic to pre-motor circuits, Competing interests: The and link indirectly to Goro rolling command-like neurons. -
Curriculum Vitae
Marta Zlatic Curriculum Vitae Personal Information Name: Marta Zlatic, Ph.D. Date of Birth: February 24th, 1977 Nationality: Croatian and British Email: [email protected] Positions • Reader in Systems and Circuits Neuroscience, University of Cambridge (appointed Oct. 2017 for planned start date Sept. 2019). • Group Leader 2, HHMI Janelia Research Campus (appointed Sept. 2016; planned end date Sept. 2019). • Group Leader 1, HHMI Janelia Research Campus (Oct. 2009 - Sept. 2016). • Research and Teaching Fellow, Trinity College, Cambridge (elected June 2016). • Junior Research Fellow, Trinity College, Cambridge (Oct. 2005 - Oct. 2009). • Wellcome Trust Prize Fellow, Department of Zoology, Cambridge (Oct. 2003 - Oct. 2005). Education and Training • Ph.D., Neurobiology 2004, Department of Zoology, University of Cambridge; Supervisor: Prof. Michael C. Bate. • M. SCI., Chemistry 2000, Hons. Cantab. Trinity College, University of Cambridge. • B. A., Natural Sciences 1999, Hons. Cantab. Trinity College, University of Cambridge. • Fluent in Croatian, English, German (Diploma, Cambridge University, 2002), French (Cer- tificate, Universite des Sciences Humaines de Strasbourg, 1998), Spanish, Russian (Diploma, Cambridge University, 2003) and Italian; literate in Ancient Greek and Latin; • Read four years of a B.A. degree in General Linguistics and Russian, at University of Zagreb Selected Awards and Scholarships (Honors) • Eric Kandel Young Neuroscientists Prize 2017 • Thomas Henry Huxley Award 2005 for the outstanding Ph.D. thesis of the year. • Trinity College (Cambridge) Junior Research Fellowship awarded Oct. 2003. • Wellcome Trust Prize Fellowship Oct. 2003–Oct. 2005. • Wellcome Trust Prize Studentship Oct. 2000–Oct. 2003. • Trinity College Eastern European Bursary Oct. 1996–Oct. 2000. Organisation of scientific consortia and meetings • Secured funding for and lead the Larval Behavior Project (Sep. -
Hhmi-Bulletin-Spring-2015 4.Pdf
hhmi bulletin • howard hughes medical institute • www.hhmi.org • institute medical hughes howard • bulletin hhmi Spring ’15 Vol. 28 No. 2 4000 Jones Bridge Road Chevy Chase, Maryland 20815-6789 www.hhmi.org Address Service Requested bulletin Plant Pavers Jigsaw puzzle-shaped cells bulging with chlorophylls (red) cover the surface of leaves in many flowering plants. The fanciful pattern is in this issue more than just a whimsical quirk of nature, however. HHMI Investigator Neural Theory at Janelia Elliot Meyerowitz and his team have shown that, as plants grow, the Marta Zlatic in the Footlights indented regions and lobe-like outgrowths of these so-called pavement Bacterial Barcodes cells create internal stresses that reorganize cytoskeletal proteins. These microtubule proteins align along the cell walls (green), a process that in turn reinforces them against stress – evidence of a subcellular mechanical feedback loop. Learn more about the role of force in the development of animals, as well as plants, in “Show of Force,” page 12. Small Forces, vol. 28 / no. 2 no. / 28 vol. Big Impact Mechanical stress plays a vital role in the development Arun Sampathkumar and Elliot Meyerowitz Elliot and Sampathkumar Arun of both animals and plants HHMI Bulletin / Spring 2015 Observations Neuroscience, it turns out, is on the brink of its own “big data” revolution. Supplementing more traditional practices of small-scale hypothesis-driven laboratory research, a growing number of large-scale brain data collection and data aggregation ventures are now underway, and prospects are that this trend will only grow in future years. Mapping the roughly one hundred trillion synaptic connections of a human brain would by some estimates generate on the order of a zettabyte of data (a zettabyte over years of observation, Hubble reported corresponds to one million petabytes). -
Conserved Neural Circuit Structure Across Drosophila Larval Development Revealed by Comparative Connectomics
RESEARCH ADVANCE Conserved neural circuit structure across Drosophila larval development revealed by comparative connectomics Stephan Gerhard1†, Ingrid Andrade1‡, Richard D Fetter1§, Albert Cardona1,2*, Casey M Schneider-Mizell1* 1Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, United States; 2Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, United Kingdom Abstract During postembryonic development, the nervous system must adapt to a growing body. How changes in neuronal structure and connectivity contribute to the maintenance of *For correspondence: appropriate circuit function remains unclear. Previously , we measured the cellular neuroanatomy [email protected] (AC); underlying synaptic connectivity in Drosophila (Schneider-Mizell et al., 2016). Here, we examined [email protected] how neuronal morphology and connectivity change between first instar and third instar larval (CMS-M) stages using serial section electron microscopy. We reconstructed nociceptive circuits in a larva of † each stage and found consistent topographically arranged connectivity between identified neurons. Present address: Friedrich Miescher Institute, Basel, Five-fold increases in each size, number of terminal dendritic branches, and total number of Switzerland; ‡Department of synaptic inputs were accompanied by cell type-specific connectivity changes that preserved the Molecular, Cell and fraction of total synaptic input associated with each pre-synaptic partner. We propose that -
Cosyne Program Book
COSYNE MAIN CONFERENCE Denver, CO: 2020 27 feb–1 mar cosyne.org Program Summary Thursday, 27 February 4:00p Registration opens 4:45p Welcome reception 6:15p Opening remarks 6:30p Session 1: The ABCs—Artificial and Biological Circuits Invited speaker: Matthew Botvinick; 2 accepted talks 8:00p Poster Session I Friday, 28 February 8:30a Session 2: Latent space Invited speaker: Mehrdad Jazayeri; 3 accepted talks 10:30a Session 3: Learning to decide Invited speaker: Linda Wilbrecht; 3 accepted talks 12:00n Lunch break 2:00p Session 4: From theory to practice Invited speaker: John Cunningham; 3 accepted talks 4:15p Session 5: Invited speaker: Marta Zlatic; 2 accepted talks 5:30p Dinner break 8:00p Poster Session II Saturday, 29 February 8:30a Session 6: Visual hierarchy Invited speaker: Hendrikje Nienborg; 3 accepted talks 10:30a Session 7: Motor learning Invited speaker: Megan Carey; 3 accepted talks 12:00n Lunch break 2:00p Session 8: Planning and exploration Invited speakers: Sam Gershman, Wei Ji Ma 4:15p Session 9: The social brain Invited speaker: Gul Dolen; 2 accepted talks 5:30p Dinner break 8:00p Poster Session III COSYNE 2020 i Sunday, 01 March 8:30a Session 10: Where am I? Invited speaker: Lisa Giocomo; 3 accepted talks 10:30a Session 11: What and where is that smell? Invited speaker: Rainer Friedrich; 3 accepted talks 12:00n Lunch break 2:00p Session 12: Can you be flexible? Invited speaker: Christopher Harvey; 3 accepted talks ii COSYNE 2020 Deep Learning for Novices and Pros Use MATLAB® to import, design, train, evaluate, and deploy deep networks Labeled Ground Truth Network Prediction Learn more at mathworks.com/deep-learning DataLogger - Wireless Neural Recording System The New DataLogger system is an untethered, battery-powered neural recording system that allows wideband continuous recording at 40 kHz sampling rate. -
All the World's a Stage
18 Marta Zlatic is as capable of portraying the Greek heroine Hecuba as she is of pulling back the curtain on the neural circuitry of fruit fly larvae. At both pursuits, she’s won wide acclaim. All the World’s a Stage by sarah goforth 19 photography by eli meir kaplan 20 Spring 2015 / HHMI Bulletin at Janelia and around the world, is building something akin to Google Maps for the larval brain, placing these layers of information on top of each other like satellite images overlaid on roadways. They are now beginning to outline, with neuron-by-neuron precision, the neural circuits that determine how a larva responds to its environment and decides what actions to take. It is no frivolous exercise. “We can look at this much simpler system, and its smaller range of behaviors, and see that many of the things we learn are the same across species,” Zlatic explains. For example, Drosophila larvae have the same sensory modalities as most animals – sound, light, odor, touch, and heat. Furthermore, they’re able to process this information, remember it, and make decisions based on it. How does a nervous system make behavioral choices based on previous experience and a multitude of sensory inputs? What can understanding this simple system tell us about the human brain and our capacity for language, art, and the pursuit of knowledge? Zlatic wants to know the answers to those questions. By all accounts, her team is already taking steps toward constructing a model for a brain atlas – one goal of the multimillion-dollar BRAIN (Brain Research through Advancing Innovative Neurotechnologies) Initiative that President Barack Obama announced in 2013. -
2016 National Drosophila Board Meeting Agenda
2016 National Drosophila Board Meeting Agenda Wednesday July 13, 2016, 3:00 - 6:00 PM New York/New Orleans room of the Orlando World Center Marriott 1. Introduction (David Bilder) 3:00-3:05 ADRC 2. Report of the 2015 Meeting Organizing Committee (Sue Celniker) 3:05-3:15 3. Treasurer’s Report (Debbie Andrew) 3:15-3:20 4. Report of the GSA Senior Director (Suzy Brown) 3:20-3:30 5. GSA and the Drosophila Board (Lynn Cooley) 3:30-3:35 6. Sandler Lectureship Committee (Daniela Drummond-Barbosa) 3:35-3:40 7. Victoria Finnerty Undergraduate Travel Award (Alexis Nagengast) 3:40-3:45 8. Image Award (Michelle Arbeitman) 3:45-3:50 9. 2017 & 2018 Fly Meetings Update (Amy Kiger) 3:50-3:55 10. ADRC Rejuvenation ad hoc committee (Howard Lipshitz) 3:55-4:05 Community 11. Drosophila Board Election Report (Amy Bejsovec) 4:05-4:10 12. Revisions to Fly Board Charter (Ken Irvine) 4:10-4:15 13. Janelia Drosophila Research Ecosystem Meeting (David Bilder) 4:15-4:20 14. Identifying members of the Fly Community (David Bilder) 4:20-4:25 15. Advocacy & Communications (Andrea Page-McCaw) 4:25-4:35 16. Primarily Undergraduate Institutions (Alexis Nagengast) 4:35-4:40 BREAK 4:40 - 4:55 Resources and Projects 17. White Paper (Ken Irvine) 4:55-5:05 18. FlyBase (Norbert Perrimon) 5:05-5:20 19. MOD support letter (David Bilder) 5:20-5:25 20. Bloomington Stock Center (Kevin Cook) 5:25-5:35 21. VDRC stock centers (Lisa Meadows) 5:35-5:40 22. -
1 Nociceptive Interneurons Control Modular Motor Pathways to Promote
1 Nociceptive interneurons control modular motor pathways to promote escape 2 behavior in Drosophila 3 4 Anita Burgos1,*, Ken Honjo2, Tomoko Ohyama3, Cheng Sam Qian1, Grace Ji-eun Shin10, 5 Daryl M. Gohl4, Marion Silies5, W. Daniel Tracey6,7, Marta Zlatic8, Albert Cardona8, 6 Wesley B. Grueber1,10,11,* 7 8 9 Running title: 10 Nociceptive interneurons in Drosophila 11 12 Affiliations 13 1Department of Neuroscience, Columbia University Medical Center, New York, NY 14 10032, USA 15 16 2Faculty of Life and Environmental Sciences, University of Tsukuba, Tsukuba, Ibaraki 17 305-8572, Japan 18 19 3Department of Biology, McGill University, Montreal, Quebec H3A 1B1, Canada 20 21 4University of Minnesota Genomics Center, 1-210 CCRB, Minneapolis, MN 55455, USA 22 23 5European Neuroscience Institute Göttingen, Grisebachstr. 5, 37077, Göttingen, Germany 24 25 6The Linda and Jack Gill Center for Biomolecular Science, Indiana University, 26 Bloomington, IN 47405-7005, USA 27 28 7Department of Biology, Indiana University, Bloomington, IN 47405-7005, USA 29 30 8Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA 20147, USA 31 1 32 10Department of Physiology and Cellular Biophysics, Columbia University Medical 33 Center, New York, NY 10032, USA 34 35 11Mortimer B. Zuckerman Mind Brain Behavior Institute, Columbia University, New 36 York, NY 10032, USA 37 38 *Contact information: [email protected]; [email protected] 39 2 40 41 Abstract 42 Rapid and efficient escape behaviors in response to noxious sensory stimuli are essential 43 for protection and survival. Yet, how noxious stimuli are transformed to coordinated 44 escape behaviors remains poorly understood. In Drosophila larvae, noxious stimuli 45 trigger sequential body bending and corkscrew-like rolling behavior.