Anti-TICAM2 Monoclonal Antibody, Clone Nbcdbn88270 (DCABH-9777) This Product Is for Research Use Only and Is Not Intended for Diagnostic Use

Anti-TICAM2 monoclonal antibody, clone nBcdbn88270 (DCABH-9777) This product is for research use only and is not intended for diagnostic use.

PRODUCT INFORMATION

Product Overview Mouse monoclonal to TICAM2

Antigen Description Functions in LPS-TLR4 signaling to regulate the MYD88-independent pathway during the innate immune response to LPS. Also involved in IL1-triggered NF-kappa-B activation, functioning upstream of IRAK1, IRAK2, TRAF6, and IKBKB. Physically bridges TLR4 and TICAM1 and functionally transmits LPS-TRL4 signal to TICAM1.

Immunogen Synthetic peptide conjugated to KLH derived from within residues 200 to the C-terminus of Human TICAM2.

Isotype IgG1

Source/Host Mouse

Species Reactivity Human

Clone nBcdbn88270

Purity IgG fraction

Conjugate Unconjugated

Applications WB, Flow Cyt

Positive Control This antibody gave a positive signal in Human Kidney and Human Spleen Tissue Lyates

Format Liquid

Size 100 μg

Buffer Preservative: 0.02% Sodium Azide; Constituents: PBS, pH 7.4

Preservative 0.02% Sodium Azide

Storage store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Ship Shipped at 4°C.

GENE INFORMATION

45-1 Ramsey Road, Shirley, NY 11967, USA Email: [email protected]

Official Symbol TICAM2

Synonyms TICAM2; toll-like receptor adaptor molecule 2; TIR domain-containing adapter molecule 2; TICAM 2; TIRP; TRAM; cytoplasmic adaptor; TRIF-related adaptor molecule; NF-kappa-B- activating protein 502; toll-like receptor adaptor protein 3; putative NF-kappa-B-

Entrez Gene ID 353376

Protein Refseq NP_067681

UniProt ID Q86XR7

Chromosome Location 5q15-q32

Pathway Activated TLR4 signalling, organism-specific biosystem; Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon, organism-specific biosystem; IKK complex recruitment mediated by RIP1, organism-specific biosystem; IL1-mediated signaling events, organism-specific biosystem; IRAK2 mediated activation of TAK1 complex, organism-specific biosystem; Immune System, organism-specific biosystem; Innate Immune System, organism-specific biosystem;

Function signal transducer activity;

45-1 Ramsey Road, Shirley, NY 11967, USA Email: [email protected]