A Delicate Balance

Total Page:16

File Type:pdf, Size:1020Kb

A Delicate Balance A Delicate Balance A Delicate Balance An effective government policy countering the COVID-19 pandemic relies on scientific advice. Still, there is a fine line to be tread to make the relationship between politics and science work well. Transparency is one key factor. By Christian Schwägerl n recent years, a phrase became popular among pathological narcissism led him to envy Fauci’s top American scientists: “When the going gets popularity among an anxious population, who Itough, go get Fauci.” The 79-year-old immunol- admired their new “explainer-in-chief.” Some peo- ogist was a kind of secret scientific weapon when ple even took to wearing t-shirts with Fauci’s face it came to dealing with politicians, and indeed the on them. It also became clear that Fauci wanted to public. Anthony Fauci is head of the NIAID, the Na- prioritize public health over short-term economic tional Institute of Allergy and Infectious Diseases. considerations, a policy Trump regarded as very Famous for his research but with no star persona, dangerous…to his re-election prospects. he can clearly explain complex scientific subjects, Dr. Fauci began to publicly express frustration sketch out their practical implications, and explain with a president who seemed quite unwilling to the consequences for politics and everyday life. learn, and who paid no heed to scientific facts, This is how, early in 2020, Dr. Fauci became the publicly recommending the drinking of bleach and public face of American science. With the corona- expressing faith in non-existent light therapies. “I virus spreading across the United States, President can’t jump in front of the microphone and push him Donald Trump eventually recognized the illness as down!” Fauci told Science magazine in March 2020. a huge and present danger, no mere Democratic By early summer, relations had badly broken hoax. Fauci stepped into the limelight, in person down. Fauci appeared in public far less often, as the at the president’s briefings, which were broadcast White House vetoed his media appearances. With worldwide. the presidential election approaching, Trump dis- But cracks soon appeared in the relations be- paraged his top scientist, calling him a “disaster,” tween the president and his top scientist. Trump’s and dismissing his own advisors as “idiots.” Fauci IP Special • 2 / 2021 | 39 The Future of Democracy was even assigned a team of bodyguards. advisor to then-President George W. Bush, By now, the rest is history. reportedly dismissed those who believed Germany’s experience in 2020 has been politics was about the close study of reali- quite different, above all because Chan- ty. “We create our own reality,” he said. Not cellor Angela Merkel is a trained scientist, so far from the “alternative facts” cited by with a PhD in physics. For Merkel, science Trump’s advisor Kellyanne Conway when is not meant to be a political performance. discussing inauguration crowd numbers She declined to push Fauci’s German coun- in 2017. terpart—Christian Drosten, the head of the This kind of thinking spread in Europe National Coronavirus Laboratory and Di- too, above all in the United Kingdom. Un- rector of the Institute for Virology at Ber- der Tony Blair’s Labour government, “spin lin’s Charité hospital—into the spotlight to doctors” ruled the roost, not people with boost her political standing, although he actual doctorates. In 2016, Conservative would have been an appropriate figure to politician Michael Gove took a directly play the role. anti-science stance: during a debate on Merkel has rarely appeared with scien- tists in public during the COVID-19 pan- demic. Behind the scenes, however, the chancellor has regularly brought scientists into discussions, as at the key meeting in October 2020 between Merkel and the lead- ers of Germany’s 16 federal states. German Chancel- On the whole, the German chancellor prefers to present the science herself. In late September, she impressed the public lor Angela Merkel with a live “back of the envelope” sci- entific calculation, used to show that, if prefers to present nothing was done, a few hundred cases in August could mean 19,200 by Christmas. But outside the public eye, she has sought the science herself out contacts with scientists. From the Robert Koch Institute to the Leopoldina (German National Academy of Sciences) and the Helmholtz Association of German Research Centers, scientific institutions have contributed knowledge to the polit- Brexit, he famously said, “People in this ical understanding of Germany’s public country have had enough of experts.” health situation. Similar trends have occurred in Hungary, where the government has the scientific A Split in the Western World community on a tight leash, and in Brazil, Christian Schwägerl These contrasting attitudes to science where President Jair Bolsonaro has tried to is one of Germany‘s could hardly be more striking. They rep- stop the publication of data on coronavirus leading science resent a deep split in the Western world, and on Amazon deforestation. journalists and co- founder of Riff- one which goes back long before Trump’s The governments of New Zealand, Reporter. 2016 victory. In 2004, Karl Rove, a close Canada, and Germany stand as counter- 40 | IP Special • 2 / 2021 A Delicate Balance examples, having at least tried to orient half of the 20th century. Scientists have policy—on climate change, the pandemic, all too willingly supported political ideol- and other issues, including dangerous de- ogies, like the Social Darwinism preached clines in biodiversity—according to scien- by Herbert Spencer. Nazi Germany’s geno- tific research. cidal plans and human experiments were To understand these conflicts around crimes substantially driven by scientists. science and politics, we need to look back The scientific community has subjected at the history of science. This does not its role in Nazi crimes to serious critical make for comfortable reading on any side scrutiny—although the process is hardly of the debate. The historical record dis- complete—and drawn broad conclusions. proves simplistic models in which “good But there has not yet been intense debate politics” always listens to “good science,” around science’s role in the imperialist while bad politics does not. and colonial genocides of the West. Since World War II, science has been Complicated Relations more obliged than ever to uphold its own Science has profoundly enriched the rela- basic values. It has not shied away from tionship between politics and society. De- presenting politicians with uncomforta- ploying evidence, arguing for proof, and ble truths. In free Western countries, im- refuting error, science has contributed to pressive networks of scientific advisors on a massive growth in material and physical political issues have been created. wellbeing, not least with breakthroughs in In Germany, this network has several medicine, agriculture, and communica- layers. In terms of government, the most tions. Beyond even that, science has also closely-integrated science is the “depart- been central to the emergence of open, mental research” carried out within fed- democratic societies. eral and state governments. These days, The early Enlightenment held to the the most prominent of these institutions is utopian idea of a Republic of Scholars, in the Robert Koch Institute, headquartered which rationality would be the only princi- in Berlin. Coronavirus research has thrust ple and guide. As science flourished, it de- this institution into the spotlight, and it veloped methods against superstition, but continues to provide the government with these also worked against aristocratic de- daily information and advice. The large sires for total power. The scientific method research institutions of the Helmholtz generated a growing body of knowledge. Association are also working closely with More importantly, however, it encouraged the Federal Ministry of Research, although a subversive process of evidence gather- they remain organizationally separate ing, which could render powerless even a from government. The Helmholtz Associ- supposedly omnipotent pope or king. ation’s research aims are adjusted regular- But an idyllic or idealistic story of sci- ly, but the basic idea remains that of free ence’s influence on politics would not tell scientific inquiry. Since the outbreak of the the whole truth. Over the last century, pol- COVID-19 pandemic, the Helmholtz Center itics and science have often made highly for Infection Research in Braunschweig problematic alliances. has played a key role in creating models Scientists were enablers and accomplic- of the pandemic’s spread. es in colonialism and played a key role in The Leopoldina is the third type of the horrific escalation of war in the first institution offering public policy advice. IP Special • 2 / 2021 | 41 The Future of Democracy The “public face of American science” began to express frustration with a president who paid no heed to facts: Dr. Anthony Fauci testifies during a hearing on the coronavirus crisis at the US Congress, July 2020 The head virologist at the Charité hospital has emphat- ically denied he was a sort of “replacement chancellor” for the time of the pandem- ic: Christian Drosten at his laboratory in Berlin 42 | IP Special • 2 / 2021 A Delicate Balance closed-mindedness is one key problem, as US President is the very narrow thematic composition of committees. For example, most aca- demic economists offering policy advice Donald Trump still wrongly regard environmental and climate protection as “externalities,” as came to denigrate if life’s natural basis could be something merely extra, an add-on to what is sup- posed to be reality. his own experts Major errors have also occurred: in Germany, demographers long predicted rapid and unavoidable population decline, and were widely listened to in the polit- ical world. However, population decline Founded in 1652, it is Germany’s oldest will probably not now occur until at least scientific organization, and strongly em- 2030.
Recommended publications
  • June 11, 2021 the Honorable Xavier Becerra Secretary Department of Health and Human Services 200 Independence Ave S.W. Washingto
    June 11, 2021 The Honorable Xavier Becerra Secretary Department of Health and Human Services 200 Independence Ave S.W. Washington, D.C. 20201 The Honorable Francis Collins, M.D., Ph.D. Director National Institutes of Health 9000 Rockville Pike Rockville, MD 20892 Dear Secretary Becerra and Director Collins, Pursuant to 5 U.S.C. § 2954 we, as members of the United States Senate Committee on Homeland Security and Governmental Affairs, write to request documents regarding the National Institutes of Health’s (NIH) handling of the COVID-19 pandemic. The recent release of approximately 4,000 pages of NIH email communications and other documents from early 2020 has raised serious questions about NIH’s handling of COVID-19. Between June 1and June 4, 2021, the news media and public interest groups released approximately 4,000 pages of NIH emails and other documents these organizations received pursuant to Freedom of Information Act requests.1 These documents, though heavily redacted, have shed new light on NIH’s awareness of the virus’ origins in the early stages of the COVID- 19 pandemic. In a January 9, 2020 email, Dr. David Morens, Senior Scientific Advisor to Dr. Fauci, emailed Dr. Peter Daszak, President of EcoHealth Alliance, asking for “any inside info on this new coronavirus that isn’t yet in the public domain[.]”2 In a January 27, 2020 reply, Dr. Daszak emailed Dr. Morens, with the subject line: “Wuhan novel coronavirus – NIAID’s role in bat-origin Covs” and stated: 1 See Damian Paletta and Yasmeen Abutaleb, Anthony Fauci’s pandemic emails:
    [Show full text]
  • The Science Fraud by Prof. Christian Drosten
    ❗ The Science Fraud by Prof. Christian Drosten Corona_Facts July 10, 2020 [Original German article https://telegra.ph/Der-Wissenschaftsbetrug-durch-Prof-Christian- Drosten-07-10] Prof. Christian Drosten is known today in principle to everyone who has ever heard of Corona, and that should be most of them. Strangely enough, few know about his strange predictions, his contradictions, his dangerous statements, like scaremongering, but worst of all is probably the obvious science fraud Drosten has committed. The question one asks oneself is, does Prof. Drosten do this out of praiseworthy thoughts, in order to regain renown from his massive mistakes (swine flu scandal), or for monetary reasons, or are there even worse reasons that I dare not address. I will show in this article that Drosten has lost the scientific code, or even does not know it at all. Both would be fatal. Let's get on with it. ! " The chronological sequence of the PCR test by Prof. Drosten and the Berlin Charité (please note the dates)" On 30.12.2019: the ophthalmologist Li Wenliang informed professional colleagues by WhatsApp that there are 7 cases in his hospital that are confirmed positive for SARS. " ———————" On 31.12.2019: the government in Beijing sent an "intervention force" of virologists and epidemiologists to support the cause in Wuhan." ———————" On 01.01.2020: Prof. Christian Drosten from the Charité heard about it and immediately started the development of SARS viruses before it was even clear and could be clear whether the report from China about SARS was true and proven, and above all before the Chinese virologists published their results! He testified that as of January 1, 2020, he had developed a genetic detection method to reliably prove the presence of the new corona virus in humans." ———————" On 21.01.2020: (3 days before the first publication of the Chinese Center for Disease Control and Prevention [CCDC]) the WHO recommended all nations to use the "safe" test procedure developed by Prof.
    [Show full text]
  • Lista De Referências Bibliográficas E Resumos– Covid -19
    LISTA DE REFERÊNCIAS BIBLIOGRÁFICAS E RESUMOS– COVID -19 Atualizado em: 23 de abril de 2021 Reduced inflammatory responses to SARS-CoV-2 infection in children presenting to hospital with COVID-19 in China Título Autor(es) Guoqing Qian, Yong Zhang, Yang Xu, Weihua Hu, Ian P. Hall , Jiang Yue , Hongyun Lu , Liemin Ruan, Maoqing Ye, Jin Mei Infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in children is associated with better outcomes than in Resumo adults. The inflammatory response to COVID-19 infection in children remains poorly characterised. Referências GUOQING Q. et al. Reduced inflammatory responses to SARS-CoV-2 infection in children presenting to hospital with COVID-19 in China. EClinicalMedicine, [Netherlands.], p. 100831, Apr. 15, 2021. Disponível em: https://doi.org/10.1016/j.eclinm.2021.100831. Fonte https://www.thelancet.com/action/showPdf?pii=S2589-5370%2821%2900111-5 1 LISTA DE REFERÊNCIAS BIBLIOGRÁFICAS E RESUMOS– COVID -19 Atualizado em: 23 de abril de 2021 Genomic characteristics and clinical effect of the emergent SARS-CoV-2 B.1.1.7 lineage in London, UK: a whole-genome sequencing Título and hospital-based cohort study Dan Frampton, Tommy Rampling, Aidan Cross, Heather Bailey, Judith Heaney, Matthew Byott, Rebecca Scott, Rebecca Sconza, Autor(es) Joseph Price, Marios Margaritis, Malin Bergstrom, Moira J Spyer, Patricia B Miralhes, Paul Grant, Stuart Kirk, Chris Valerio, Zaheer Mangera, Thaventhran Prabhahar, Jeronimo Moreno-Cuesta, Nish Arulkumaran, Mervyn Singer, Gee Yen Shin, Emilie Sanchez, Stavroula M Paraskevopoulou, Deenan Pillay, Rachel A McKendry, Mariyam Mirfenderesky, Catherine F Houlihan, Eleni Nastouli Emergence of variants with specific mutations in key epitopes in the spike protein of SARS-CoV-2 raises concerns pertinent to mass Resumo vaccination campaigns and use of monoclonal antibodies.
    [Show full text]
  • Publication Title
    WHO R&D Blueprint novel Coronavirus COVID-19 Viruses, Reagents and Immune Assays WHO Working Group WHO reference number © World Health Organization 2020. All rights reserved. Terms of Reference WG established on February 2020 Table of Contents TABLE OF CONTENTS ............................................................................................................................... 2 BACKGROUND ............................................................................................................................................ 3 TERMS OF REFERENCE ............................................................................................................................ 3 COMPOSITION ............................................................................................................................................. 3 EXPERTS .................................................................................................................................................... 3 WHO SECRETARIAT .................................................................................................................................... 6 2 Terms of Reference WG established on February 2020 Background In response to the current COVID-19 pandemic, the WHO Blueprint team has established an Expert Group focused on COVID-19 viruses, reagents and immune assays. The goal of the group is to advance the development of COVID-19 medical countermeasures (vaccines and immunotherapeutics). This is being achieved by providing a platform to discuss
    [Show full text]
  • Masstag Polymerase Chain Reaction for Differential Diagnosis of Viral
    DISPATCHES virus, Machupo virus, and Sabiá virus (Arenaviridae); Rift MassTag Valley fever virus (RVFV), Crimean-Congo hemorrhagic fever virus (CCHFV), and hantaviruses (Bunyaviridae); Polymerase Chain and Kyasanur Forest disease virus (KFDV), Omsk hemor- rhagic fever virus, yellow fever virus (YFV), and dengue Reaction for viruses (Flaviviridae) (1,2). Although clinical management of VHF is primarily supportive, early diagnosis is needed to Differential contain the contagion and implement public health meas- ures, especially if agents are encountered out of their natu- Diagnosis of Viral ral geographic context. Vaccines have been developed for YFV, RVFV, Junín Hemorrhagic Fevers virus, KFDV, and hantaviruses (3–7), but only YFV vac- cine is widely available. Early treatment with immune plas- Gustavo Palacios,*1 Thomas Briese,*1 ma was effective in Junín virus infection (8). The Vishal Kapoor,* Omar Jabado,* Zhiqiang Liu,* nucleoside analog ribavirin may be helpful if given early in Marietjie Venter,† Junhui Zhai,* Neil Renwick,* the course of Lassa fever (9), Crimean-Congo hemorrhagic Allen Grolla,‡ Thomas W. Geisbert,§ fever (10), or hemorrhagic fever with renal syndrome (11) Christian Drosten,¶ Jonathan Towner,# and is recommended in postexposure prophylaxis and early Jingyue Ju,* Janusz Paweska,** treatment of arenavirus and bunyavirus infections (12). Stuart T. Nichol,# Robert Swanepoel,** Methods for direct detection of nucleic acids of micro- Heinz Feldmann,‡†† Peter B. Jahrling,‡‡ bial pathogens in clinical specimens are rapid, sensitive, and W. Ian Lipkin* and obviate the need for high-level biocontainment. Viral hemorrhagic fevers are associated with high Numerous systems are described for nucleic acid detection rates of illness and death. Although therapeutic options are of VHF agents; however, none are multiplex (13).
    [Show full text]
  • Battling Misinformation with Science Promoting Science Communication to Fight Misinformation in Germany
    Policy Paper | February 2021 Battling Misinformation with Science Promoting Science Communication to Fight Misinformation in Germany Markus Weißkopf and Rebecca Winkels Facing up to the Infodemic: Promoting a Fact-Based Public Discourse in Times of Crisis Policy Paper Series by the Israel In Cooperation with: Public Policy Institute (IPPI) Battling Misinformation with Science Promoting Science Communication to Fight Misinformation in Germany Authors About the Project Markus Weißkopf Rebecca Winkels This paper series is part of the broader project “Fostering Democratic Resilience in the Digital About this Paper Age,” conceptualized and executed by the Israel Public Policy Institute (IPPI) in collaboration with the Heinrich Böll Foundation, Tel Aviv. This policy paper is part of the paper series “Facing up to the Infodemic: Promoting a Fact- The objective of the project is to promote Based Public Discourse in Times of Crisis.” dialogue, exchange of knowledge and collaboration between researchers and Against the backdrop of the COVID-19 crisis, practitioners from Israel and abroad to enhance this paper series explores some of the key democratic resilience in the context of the challenges facing democratic societies as changing media and information landscape in a result of misinformation in the digital the digital age. public sphere. It features a unique mosaic of perspectives and insights by experts from Israel and Germany that shed light on different facets of the phenomenon of online Please cite as follows: misinformation, with the aim of invigorating a societal debate on the issue as well as offering Weißkopf, M., & Winkels, R. (2021). Battling concrete ideas about how to address it.
    [Show full text]
  • What Do Young People Think About Social Distancing During the Corona Crisis in Germany?
    What do young people think about social distancing during the Corona crisis in Germany? Marc Oliver Rieger1 University of Trier Germany March 25, 2020 Abstract In a survey among 250 subjects recruited at a German university and predominantly university students, we elicit opinions about social distancing, i.e. the necessity to keep away from other people to slow down the speed of the ongoing SARS-CoV2 epidemics. The good news is that most students are supportive to it. A minority, however, does not completely agree. We find that how many elderly persons subjects knew personally, was the most significant factor for their attitudes towards social distancing. We also found a significant negative impact of believe in conspiracy theories on these attitudes. These theories have a low, but non-negligible number of proponents, even among university students. Moreover, a certain degree of mistrust to media is widespread (around a third of the subjects). To improve positive attitudes to social distancing and thus to improve compliance we recommend therefore to emphasize relations of persons to elderly people more and to continue fighting against fake news and conspiracy theories regarding SARS-CoV2. 1 Introduction The current pandemics of the new type of coronavirus, SARS-CoV2, poses a global challenge. As of writing of this paper, in most countries around the world an exponential growth of cases and deaths is witnessed, with the notable exception of China where the disease started initially [1] and where it currently seems to be retained. In many countries, first in China, strict counter measures have been implemented, including closing of schools, universities and non- essential businesses as well as restricting individual mobility.
    [Show full text]
  • Outbreak of SARS Cov 2 B.1.1.7 Lineage After Vaccination in German Long Term Care
    Outbreak of SARS-CoV-2 B.1.1.7 Lineage after Vaccination in Long-Term Care Facility, Germany, February–March 2021 Pinkus Tober-Lau,1 Tatjana Schwarz,1 David Hillus, Jana Spieckermann, Elisa T. Helbig, Lena J. Lippert, Charlotte Thibeault, Willi Koch, Leon Bergfeld, Daniela Niemeyer, Barbara Mühlemann, Claudia Conrad, Stefanie Kasper, Friederike Münn, Frank Kunitz, Terry C. Jones, Norbert Suttorp, Christian Drosten, Leif Erik Sander,2 Florian Kurth,2 Victor M. Corman2 One week after second vaccinations were administered, fi rst week after the second dose (3). Although break- an outbreak of B.1.1.7 lineage severe acute respiratory through infections have been reported, vaccinated syndrome coronavirus 2 infections occurred in a long- persons were at substantially lower risk for infection term care facility in Berlin, Germany, aff ecting 16/20 vac- and symptomatic disease (4,5). cinated and 4/4 unvaccinated residents. Despite consid- The variant of concern (VOC) B.1.1.7 rapidly erable viral loads, vaccinated residents experienced mild became the predominant lineage in Europe in 2021. symptoms and faster time to negative test results. Analyses estimated that B.1.1.7 has increased trans- missibility and a <0.7 higher reproduction number utbreaks of severe acute respiratory syndrome (6). Neutralization activity of serum samples from Ocoronavirus 2 (SARS-CoV-2) in long-term care BNT162b2-vaccinated persons has been shown to facilities (LTCF) are of great concern and have been be slightly reduced against B.1.1.7 in cell culture (7), reported to have high case-fatality rates (1). Conse- but observational data from Israel suggest BNT162b2 quently, national vaccination strategies prioritize res- vaccination is effective against B.1.1.7 (8).
    [Show full text]
  • First Past the Post
    news feature First past A. ABBOTT the post From the moment the mysterious illness known as SARS was declared a global threat to health, virologists were racing to develop a diagnostic test. Alison Abbott visits the tiny German lab that got there first. World-beater: Christian Drosten burned the midnight oil to be the first to produce a rapid test for SARS. hristian Drosten is exhausted, but institute to see if a tropical virus might be Drosten sped back to Hamburg with a last week he was putting on a brave involved, it fell into Drosten’s hands. sample on 22 March. His new series of PCR Cface for the television crews trying to Having ruled out the obvious tropical tests took him through a sleepless weekend, squeeze into his poky lab. Drosten’s fatigue, viruses, Drosten began to think about rare during which the machine he was using to and his sudden celebrity, both stem from viruses that might cause symptoms similar sequence the genetic material being ampli- the fact that his team developed the first to SARS. He first fixated on the family of fied failed. But by 25 March, the recalcitrant diagnostic test for severe acute respiratory paramyxoviruses, whose members include device had delivered 20 or so sequences. syndrome (SARS). the rare Hendra and Nipah viruses, which Two of these matched up with sequences Remarkably, Drosten and his colleagues can jump from animals to people. “Frankfurt from the coronavirus family. But just as the pulled off this feat just 11 days after the World colleagues had looked at the patient’s sputum coronavirus sequence was coming off the Health Organization (WHO) issued its alert sample under the electron microscope, and machine in Hamburg, researchers at the US about the disease.
    [Show full text]
  • File Download
    Discovery of a unique novel clade of mosquito-associated bunyaviruses Marco Marklewitz, University of Bonn Florian Zirkel, University of Bonn Innocent B. Rwego, University of Bonn Hanna Heidemann, University of Bonn Pascal Trippner, University of Bonn Andreas Kurth, Robert Koch Institute René Kallies, University of Bonn Thomas Briese, Columbia University W. Ian Lipkin, Columbia University Christian Drosten, University of Bonn Only first 10 authors above; see publication for full author list. Journal Title: Journal of Virology Volume: Volume 87, Number 23 Publisher: American Society for Microbiology | 2013-12-01, Pages 12850-12865 Type of Work: Article | Final Publisher PDF Publisher DOI: 10.1128/JVI.01862-13 Permanent URL: https://pid.emory.edu/ark:/25593/s5s1n Final published version: http://dx.doi.org/10.1128/JVI.01862-13 Copyright information: © 2013, American Society for Microbiology. Accessed September 28, 2021 11:16 AM EDT Discovery of a Unique Novel Clade of Mosquito-Associated Bunyaviruses Marco Marklewitz,a Florian Zirkel,a Innocent B. Rwego,b,c,d* Hanna Heidemann,a Pascal Trippner,a Andreas Kurth,e René Kallies,a Thomas Briese,f W. Ian Lipkin,f Christian Drosten,a Thomas R. Gillespie,b,c Sandra Junglena Institute of Virology, University of Bonn Medical Centre, Bonn, Germanya; Department of Environmental Studies and Program in Population Biology, Ecology and Evolution, Emory University, Atlanta, Georgia, USAb; Department of Environmental Health, Rollins School of Public Health, Emory University, Atlanta, Georgia, USAc; College of Natural Sciences, Makerere University, Kampala, Ugandad; Centre for Biological Threats and Special Pathogens, Robert Koch Institute, Berlin, Germanye; Center for Infection and Immunity, Mailman School of Public Health, Columbia University, New York, New York, USAf Bunyaviruses are the largest known family of RNA viruses, infecting vertebrates, insects, and plants.
    [Show full text]
  • Genetische Impfstoffe Gegen COVID-19: Hoffnung Oder Risiko?
    TRIBÜNE COVID-19 862 Genetische Impfstoffe gegen COVID-19: Hoffnung oder Risiko? Clemens Arvay Dipl.-Ing., Biologe, freier Autor, Graz Es wird häufig davon ausgegangen, dass sich das globale Sozialleben erst normalisie- ren wird, wenn ein Impfstoff gegen SARS-CoV2 zur Verfügung steht. Fast die Hälfte der Impfstoffkandidaten sind genetische Impfstoffe, welche einige gesundheitliche Risiken bergen. Die Biologie von SARS-CoV-2 peripher-genetische Abläufe in der Wirtszelle findet die Translation der Boten-RNA an den Ribosomen SARS-CoV-2 gehört zur Familie der Coronaviren (Coro- statt, in denen die Proteinbiosynthese abläuft. In der naviridae). Das virale Genom liegt bei diesen nicht als Folge kommt es zur Synthese viraler Proteine [2]. DNA (Desoxyribonukleinsäure), sondern als RNA (Ri- bonukleinsäure) vor. Die Virionen des Erregers mit ei- nem Durchmesser von etwa 120 nm bestehen aus einer Genbasierte Impfstoffe Lipiddoppelschichthülle mit Membran- und Stachel- proteinen, in deren Inneren die genomische RNA Viele Experten gehen davon aus, dass sich unser Alltag (vRNA für «viral RNA») im Querschnitt ringförmig im erst normalisieren wird, wenn ein wirksamer Impf- Nukleokapsid angeordnet ist [1]. stoff gegen SARS-CoV-2 zur Verfügung steht [3]. Unter Nach dem Eintritt in die Wirtszelle kommt es dort zur den Kandidaten befindet sich ein signifikanter Anteil Expression der Boten-RNA (mRNA für «messenger genbasierter, das heisst auf der Transduktion von RNA»), die aus einsträngigen Transkripten von Ab- Nuklein säuren in die menschliche Zielzelle aufbauen- schnitten der viralen RNA besteht. Über Eingriffe in der Impfstoffe [4]. Bei der Weltgesundheitsorganisa- tion (WHO) wurden von pharmazeutischen Unterneh- men 18 RNA- und 11 DNA-basierte Impfstoffstudien für RNA – Impfstoffe (18) eine Immunisierung gegen COVID-19 angemeldet (von 13,64% 132) [5].
    [Show full text]
  • Diversity and Evolutionary Origin of the Virus Family Bunyaviridae
    Diversity and Evolutionary Origin of the Virus Family Bunyaviridae Dissertation zur Erlangung des Doktorgrades (Dr. rer. nat.) der Mathematisch-Naturwissenschaftlichen Fakultät der Rheinischen Friedrich-Wilhelms-Universität Bonn vorgelegt von Marco Marklewitz aus Hannover Bonn, 2016 Angefertigt mit Genehmigung der Mathematisch-Naturwissenschaftlichen Fakultät der Rheinischen Friedrich-Wilhelms-Universität Bonn 1. Gutachter: Prof. Dr. Christian Drosten 2. Gutachter: Prof. Dr. Bernhard Misof Tag der Promotion: 21.12.2016 Erscheinungsjahr: 2017 Danksagung Zu Beginn möchte ich mich ganz herzlich bei meinem Doktorvater Prof. Christian Drosten bedanken, dass er mir ermöglicht hat, an einem solch vielfältigen und spannenden Thema zu arbeiten. Für Fragen hatte er jederzeit ein offenes Ohr und bei auftretenden Problemen war er immer sehr hilfsbereit. Des Weiteren möchte ich mich herzlich bei meiner Prüfungskommission, bestehend aus meinem 2. Gutachter Prof. Bernhard Misof sowie Prof. Clemens Simmer und PD Dr. Lars Podsiadlowski, für ihre Zeit und Bereitschaft danken mich zu prüfen. Mein ganz besonder Dank geht an PD Dr. Sandra Junglen für ihre hervorragende und kompetente Betreuung während der Jahre meiner Doktorarbeit. Ich habe es als eine Ehre empfunden, ein Teil ihrer zu Beginn noch sehr jungen Arbeitsgruppe zu sein, danke ihr sehr für ihr Vertrauen und hoffe, sie mit meiner (zukünftigen) Arbeit stolz zu machen. Die Atmosphäre in ihrer Arbeitsgruppe ist immer sehr positiv und ermöglicht, die Arbeit mit viel Spaß zu verbinden. Insbesondere möchte ich herausstellen, dass ich ihr für die Möglichkeit besonders dankbar bin, neben meiner Doktorarbeit Feldarbeiten in Panama durchzuführen. Diese Zeit hat mein Leben auf die positivste Art und Weise nachhaltig beeinflusst. Mein großer Dank gilt auch allen Kolleginnen und Kollegen in den Virologie-Laboratorien der Augenklinik für ihre ständige Hilfs- und Diskussionsbereitschaft, ihr Zuhören bei Problemen sowie für ihre Freundschaft über all die Jahre.
    [Show full text]