NSAC Minutes 03182021 Final
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And Should Not, Change Toxic Tort Causation Doctrine
THE MORE WE KNOW, THE LESS INTELLIGENT WE ARE? - HOW GENOMIC INFORMATION SHOULD, AND SHOULD NOT, CHANGE TOXIC TORT CAUSATION DOCTRINE Steve C. Gold* Advances in genomic science are rapidly increasing our understanding of dis- ease and toxicity at the most fundamental biological level. Some say this heralds a new era of certainty in linking toxic substances to human illness in the courtroom. Others are skeptical. In this Article I argue that the new sciences of molecular epidemiology and toxicogenomics will evince both remarkable explanatory power and intractable complexity. Therefore, even when these sciences are brought to bear, toxic tort claims will continue to present their familiar jurisprudential problems. Nevertheless, as genomic information is used in toxic tort cases, the sci- entific developments will offer courts an opportunity to correct mistakes of the past. Courts will miss those opportunities, however, if they simply transfer attitudesfrom classical epidemiology and toxicology to molecular and genomic knowledge. Using the possible link between trichloroethyleneand a type of kidney cancer as an exam- ple, I describe several causation issues where courts can, if they choose, improve doctrine by properly understanding and utilizing genomic information. L Introduction ............................................... 370 II. Causation in Toxic Torts Before Genomics ................... 371 A. The Problem .......................................... 371 B. Classical Sources of Causation Evidence ................ 372 C. The Courts Embrace Epidemiology - Perhaps Too Tightly ................................................ 374 D. Evidence Meets Substance: Keepers of the Gate ......... 379 E. The Opposing Tendency ................................ 382 III. Genomics, Toxicogenomics, and Molecular Epidemiology: The M ore We Know ........................................ 383 A. Genetic Variability and "Background" Risk .............. 384 B. Genetic Variability and Exposure Risk ................... 389 C. -
Dean, School of Science
Dean, School of Science School of Science faculty members seek to answer fundamental questions about nature ranging in scope from the microscopic—where a neuroscientist might isolate the electrical activity of a single neuron—to the telescopic—where an astrophysicist might scan hundreds of thousands of stars to find Earth-like planets in their orbits. Their research will bring us a better understanding of the nature of our universe, and will help us address major challenges to improving and sustaining our quality of life, such as developing viable resources of renewable energy or unravelling the complex mechanics of Alzheimer’s and other diseases of the aging brain. These profound and important questions often require collaborations across departments or schools. At the School of Science, such boundaries do not prevent people from working together; our faculty cross such boundaries as easily as they walk across the invisible boundary between one building and another in our campus’s interconnected buildings. Collaborations across School and department lines are facilitated by affiliations with MIT’s numerous laboratories, centers, and institutes, such as the Institute for Data, Systems, and Society, as well as through participation in interdisciplinary initiatives, such as the Aging Brain Initiative or the Transiting Exoplanet Survey Satellite. Our faculty’s commitment to teaching and mentorship, like their research, is not constrained by lines between schools or departments. School of Science faculty teach General Institute Requirement subjects in biology, chemistry, mathematics, and physics that provide the conceptual foundation of every undergraduate student’s education at MIT. The School faculty solidify cross-disciplinary connections through participation in graduate programs established in collaboration with School of Engineering, such as the programs in biophysics, microbiology, or molecular and cellular neuroscience. -
ISC) of International Solar Alliance (ISA)
Report of the 2nd Meeting of International Steering Committee (ISC) of International Solar Alliance (ISA) Held on 18th January, 2016 at Abu Dhabi, UAE The Steering Committee of the International Solar Alliance, open to all member countries, held its second meeting on 18th January 2016 at the Abu Dhabi National Exhibition Centre (ADNEC), Abu Dhabi, UAE. India, represented by Mr Upendra Tripathy, Secretary, Ministry of New and Renewable Energy (MNRE), Government of India, chaired the meeting. Ms. Sylvie Lemmet, Director, European and International Affairs, French Ministry of Ecology, Sustainable Development and Energy, Government of France was the Co-chair. 2. Thirty countries including India and France attended the meeting. List of country representatives is given at Appendix-I. Observers and potential partners who attended the meeting are listed at Appendix-II. 3. The agenda items were taken up in the following order:- Agenda Item 1: Opening remarks by the Chair 4. Mr Upendra Tripathy, Secretary to Government of India, Ministry of New and Renewable Energy, in the Chair, welcomed all the participating Countries and thanked them for joining the 2nd ISC meeting of ISA. He thanked the Ambassadors and High Commissioners of prospective member countries located in New Delhi who have been of great help in ensuring speed, skill and scale in the process that has made it possible to have two ISC meetings in a time span of 49 days, since ISA was launched in Paris. He briefly apprised the members about the political Declaration, enclosed with the joint invitation letter from the Hon’ble Prime Minister of India and the President of France, that brought together in Paris on 30th November 2015 representatives from around 70 countries including more than 30 Heads of State Government, 500 high level representatives from government and international organizations, and 50 representatives from the industry. -
A Bold New Approach for Space Exploration and Discovery
Office of Science and Technology Policy National Aeronautics and Space Administration FACT SHEET A Bold New Approach for Space Exploration and Discovery • Adds $6 billion to NASA’s budget over five years and draws upon American ingenuity to enable us to embark on an ambitious 21st century program of human space exploration and observation of the Earth and the Universe. • Ends NASA’s Constellation program, which was planning to use an approach similar to the Apollo program to return astronauts to the Moon 50 years after that program’s triumphs. An independent panel found that Constellation was years behind schedule and would require large budget increases to land even a handful of astronauts back on the Moon before 2030. Instead, we are launching a bold new effort that invests in American ingenuity to develop more capable and innovative technologies for future space exploration. • In consultation with our partners, extends operation of the International Space Station likely to 2020 or beyond and enhances its utilization, bringing nations together in a common pursuit of discovery in space. • Initiates several new programs to transform the state of the art in space technologies, including flagship exploration technology development and demonstration programs, investments in early-stage advanced concepts, potential “game-changing” technologies, and new propulsion technologies – all intended to increase the reach and reduce the costs of future human space exploration as well as other NASA, government, and commercial space activities. • Enhances the Nation’s global climate change research and monitoring system, accelerating decadal survey missions and re-flying a satellite that will identify global carbon sources and sinks. -
Simulating Nuclear and Astrophysical Processes in the Lab. Artemis Spyrou
The nuclear Physics of exploding stars: simulating nuclear and astrophysical processes in the lab. Artemis Spyrou [email protected] @ArtemisSpyrou • Nuclear Astrophysics • Nucleosynthesis • Nuclear Physics Input • Sample project description Figure Credit: Erin O’Donnel, NSCL Artemis Spyrou, September 2018,2017, Slide 1 Elements in nature 1 2 H He 3 4 5 6 7 8 9 10 Li Be B C N O F Ne 11 12 13 14 15 16 17 18 Na Mg Al Si P S Cl Ar 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 K Ca Sc Ti V Cr Mn Fe Co Ni Cu Zn Ga Ge As Se Br Kr 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 Rb Sr Y Zr Nb Mo Tc Ru Rh Pd Ag Cd In Sn Sb Te I Xe 55 56 57 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 Cs Ba La Hf Ta W Re Os Ir Pt Au Hg Tl Pd Bi Po At Rn 87 88 89 104 105 106 107 108 109 110 Fr Ra Ac Rf Ha Sg Bh Hs Mt Ds … 58 59 60 61 62 63 64 65 66 67 68 69 70 71 Ce Pr Nd Pm Sm Eu Gd Tb Dy Ho Er Tm Yb Lu 90 91 92 93 94 95 96 97 98 99 100 101 102 103 Th Pa U Np Pu Am Cm Bk Cf Es Fm Md No Lr Artemis Spyrou, September 2018,2017, Slide 2 Elements in nature 1 2 H He 3 Li BANG Artemis Spyrou, September 2018,2017, Slide 3 Elements in nature 1 The rest… made in stars!!! 2 H He 3 4 5 6 7 8 9 10 Li Be B C N O F Ne 11 12 13 14 15 16 17 18 Na Mg Al Si P S Cl Ar 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 K Ca Sc Ti V Cr Mn Fe Co Ni Cu Zn Ga Ge As Se Br Kr 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 Ag Cd I Rb Sr BANGY Zr Nb Mo Tc Ru Rh Pd In Sn Sb Te Xe 55 56 57 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 Cs Ba La Hf Ta W Re Os Ir Pt Au Hg -
The U.S. Department of Energy's Ten-Year-Plans for the Office Of
U.S. DEPARTMENT OF ENERGY The U.S. Department of Energy’s Ten-Year-Plans for the Office of Science National Laboratories FY 2019 FY 2019 Annual Laboratory Plans for the Office of Science National Laboratories i Table of Contents Introduction ................................................................................................................................................................1 Ames Laboratory ........................................................................................................................................................3 Lab-at-a-Glance ......................................................................................................................................................3 Mission and Overview ............................................................................................................................................3 Core Capabilities .....................................................................................................................................................4 Science Strategy for the Future ..............................................................................................................................8 Infrastructure .........................................................................................................................................................8 Argonne National Laboratory ................................................................................................................................. -
Jet-Track Correlation Studies of the Quark Gluon Plasma
Jet-Track Correlation Studies of the Quark Gluon Plasma BY HALLIE CAUSEY TRAUGER M.Ed. University of Illinois at Chicago, 2015 M.S. University of Illinois at Chicago, 2014 B.A. University of Chicago, 2010 THESIS Submitted in partial fulfilment of the requirements for the degree of Doctor of Philosophy in Physics in the Graduate College of the University of Illinois at Chicago, 2017 CERN-THESIS-2017-209 Chicago, IL DEFENSE COMMITTEE: Olga Evdokimov, Chair and Advisor David Hofman Zhenyu Ye Mikhail Stephanov Julia Velkovska, Vanderbilt University For my students, with the hope that they, too, may enjoy the privilege of following their curiosity and passions wherever these may lead. ii ACKNOWLEDGEMENTS I owe the opportunity to earn a PhD almost entirely to my advisor Olga Evdokimov, who convinced me to pursue research and invested countless hours in teaching, coaching, and mentoring me. I am also indebted to all the professors and staff members at UIC who took chances on me, and provided me with the opportunities and support I needed to learn. In particular, I thank my Preliminary Examination and Dissertation committee members, Professors Evdokimov, Hofman, Ye, Stephanov, Cavanaugh, and Velkovska for their time, flexibility, and support. I also would like to thank my collaborators in CMS for their patience, availability, and invaluable thorough feedback. I thank my fellow graduate students and post-docs in UIC, especially Kolja Kauder and Pelin Kurt who, along with Professor Evdokimov, helped me get started with ROOT and in CMS, and the friends that made the first few years of graduate school fun and studying for qualifying exams tolerable. -
Precision Medicine Initiative: Building a Large US Research Cohort
Precision Medicine Initiative: Building a Large U.S. Research Cohort February 11-12, 2015 PARTICIPANT LIST Goncalo Abecasis, D. Phil. Philip Bourne, Ph.D. Professor of Biostatistics Associate Director for Data Science University of Michigan, Ann Arbor Office of the Director National Institutes of Health Christopher Austin, M.D. Director Murray Brilliant, Ph.D. National Center for Advancing Translational Sciences Director National Institutes of Health Center for Human Genetics Marshfield Clinic Research Foundation Vikram Bajaj, Ph.D. Chief Scientist Greg Burke, M.D., M.Sc. Google Life Sciences Professor and Director Wake Forest School of Medicine Dixie Baker, Ph.D. Wake Forest University Senior Partner Martin, Blanck and Associates Antonia Calafat, Ph.D. Chief Dana Boyd Barr, Ph.D. Organic Analytical Toxicology Branch Professor, Exposure Science and Environmental Health Centers for Disease Control and Prevention Rollins School of Public Health Emory University Robert Califf, M.D. Vice Chancellor for Clinical and Translational Research Jonathan Bingham, M.B.A. Duke University Medical Center Product Manager, Genomics Google, Inc. Rex Chisholm, Ph.D. Adam and Richard T. Lind Professor of Medical Eric Boerwinkle, Ph.D. Genetics Professor and Chair Vice Dean for Scientific Affairs and Graduate Studies Human Genetics Center Associate Vice President for Research University of Texas Health Science Center Northwestern University Associate Director Human Genome Sequencing Center Rick Cnossen, M.S. Baylor College of Medicine Director Global Healthcare Solutions Erwin Bottinger, M.D. HIMSS Board of Directors Professor PCHA/Continua Health Alliance Board of Directors The Charles Bronfman Institute for Personalized Intel Corporation Medicine Icahn School of Medicine at Mount Sinai - 1 - Francis Collins, M.D., Ph.D. -
Agency Information
Quadrennial Technology Review 2015 Chapter 1: Energy Challenges Supplemental Information Additional Information on Energy Challenges Agency Information Representative DOE Science and Energy Program Workshops U.S. DEPARTMENT OF ENERGY Quadrennial Technology Review 2015 Agency Information Chapter 1: Supplemental Information Agency Information Many Federal Departments and Agencies conduct research, development, demonstration, and deployment (RDD&D) activities, policy and regulatory activities, and other actions related to clean energy technologies, as do many State Agencies. The following websites provide a starting point for examining some of the excellent work done by these Federal Agencies—with a primary focus on RDD&D activities, as well as those providing data and information helpful for informing those activities. State and local activities are not covered here. This is not a complete list across agencies or within agencies, only a starting point. For all of these agencies, searching their websites for the energy-related topics of interest is the best way to get up-to-date information. For regulatory and policy issues, the work done by the Quadrennial Energy Review provides a useful overview and framework.1 AGENCY/DIVISION and URL: Executive Office of the President (EOP) https://www.whitehouse.gov/administration/eop Council on Environmental Quality (CEQ) https://www.whitehouse.gov/administration/eop/ceq National Security Council (NSC) https://www.whitehouse.gov/administration/eop/nsc Office of Management and Budget (OMB) https://www.whitehouse.gov/omb Office of Science and Technology Policy (OSTP) https://www.whitehouse.gov/administration/eop/ostp U.S. Department of Agriculture (USDA) http://www.usda.gov/wps/portal/usda/usdahome http://www.usda.gov/wps/portal/usda/usdahome?navid=ENERGY http://www.usda.gov/oce/energy/ http://www.ars.usda.gov/research/programs/programs.htm?NP_CODE=307 http://www.usda.gov/oce/reports/index.htm#renewable http://www.rd.usda.gov/about-rd/agencies/rural-utilities-service U.S. -
BC Eyes Role with Reservoir
Renovations raise the roof with neighbors ~PAGE9 mcomm aper Company www .allstonbrightontab.com FRIDAY, JULY 11, 2003 Vo l. 7, No. 51 II 44 Pages 3 Sections 75¢ 'Pick me, pick me!' BC eyes role with reservoir By Phoebe Sweet STAFF WRITER s the state is poised to Waterworks sell off the historic Wa developer to be A terworks buildi ngs to a local developer, Boston College named soon is indicating intere t in control ling the abutting reservoir. By Phoebe Sweet College officials recently an STAFF WRITER nounced that BC is interested in fter years of waiting, taking on the role of"steward" of A neighbors to the the reservoir and plans to spend CheMnut Hill Waterworks up to $3 mi ll ion on repairs and may soon know the identi cleanup. ty of the futu re steward of This public/private partnershi p the t.:entury-old buildings. would incl ude a substantial After accepti ng supple cleanup effort and increased safe mentary in formation fro m ty provisions and lighting. each of three developers BC officials told neighbors at a competing for the right to recent BC Task Force meeting buy the Cleveland Circle that they have contacted Secre site, state official$ said this tary of Commonwealth Develop week that they expect to ment Doug Foy to initiate the choose a developer by the process end of the month. ,. BY ZARA Tl.»LV And although a BC spokesman "lt is anticipated that a Magtclan Arthur Atsma picks an assistant for a trick during last week's Faneuil Street Fun Night, sponsored by the Abundant Grace seemed optimistic that both the Church. -
Farnam Jahanian,Kathleen Hogan,Debbie Guild,Daron Green
Nina Johal Nina joined Amazon in May of 2019 as the Talent Acquisition leader for the technology teams in Worldwide Operations. She is directly responsible for strategy, sourcing, and hiring of technical talent for over 10 North American development centers spanning seven distinct business units. She also liaisons with global counterparts to ensure the strategic delivery of regional technical recruitment needs. Nina has deep HR experience both domestically and internationally and has held a variety of roles throughout her 26-year career at Microsoft. In her most recent role at Microsoft she was responsible for all Executive level recruiting across the company. Nina is Canadian and lives in Bellevue, Washington with her husband and son. She enjoys family time, traveling, working out, fine wines and reading. First Name Nina Last Name Johal Organization Amazon Position Talent Acquisition Director, Operations Technology Farnam Jahanian Farnam Jahanian was appointed interim president of Carnegie Mellon University by its Board of Trustees, effective July 1, 2017. As provost and chief academic officer beginning in 2015, Jahanian had broad responsibility for leading CMU’s schools, colleges, institutes, and campuses and was instrumental in long- range institutional and academic planning, including efforts to enhance the CMU experience both within and outside the classroom. Before being named provost in May 2015, he previously served as the university’s vice president for research, nurturing excellence in research, scholarship and creative activities. Prior to coming to CMU, Jahanian led the National Science Foundation Directorate for Computer and Information Science and Engineering (CISE) from 2011 to 2014. He guided CISE, with a budget of almost $900 million, in its mission to advance scientific discovery and engineering innovation through its support of fundamental research. -
Years 2018, 2017, and 2016, Research and Development Expense Was $14.7 Billion, $13.0 Billion, and $12.0 Billion, Respectively
UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 10-K ☒ ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the Fiscal Year Ended June 30, 2018 OR ☐ TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE ACT OF 1934 For the Transition Period From to Commission File Number 001-37845 MICROSOFT CORPORATION WASHINGTON 91-1144442 (STATE OF INCORPORATION) (I.R.S. ID) ONE MICROSOFT WAY, REDMOND, WASHINGTON 98052-6399 (425) 882-8080 www.microsoft.com/investor Securities registered pursuant to Section 12(b) of the Act: COMMON STOCK, $0.00000625 par value per share NASDAQ Securities registered pursuant to Section 12(g) of the Act: NONE Indicate by check mark if the registrant is a well-known seasoned issuer, as defined in Rule 405 of the Securities Act. Yes ☒ No ☐ Indicate by check mark if the registrant is not required to file reports pursuant to Section 13 or Section 15(d) of the Exchange Act. Yes ☐ No ☒ Indicate by check mark whether the registrant (1) has filed all reports required to be filed by Section 13 or 15(d) of the Securities Exchange Act of 1934 during the preceding 12 months (or for such shorter period that the registrant was required to file such reports), and (2) has been subject to such filing requirements for the past 90 days. Yes ☒ No ☐ Indicate by check mark whether the registrant has submitted electronically and posted on its corporate website, if any, every Interactive Data File required to be submitted and posted pursuant to Rule 405 of Regulation S-T (§232.405 of this chapter) during the preceding 12 months (or for such shorter period that the registrant was required to submit and post such files).