Chemistry and Biochemistry 1

students. Inquiries regarding these opportunities should be directed to CHEMISTRY AND the graduate program coordinator. BIOCHEMISTRY Degrees for the Department Bachelor Degree(s) Undergraduate Program Information Chemistry - Bachelor of Arts A degree in chemistry or biochemistry enables a student to pursue a wide variety of careers in: research, production, sales, management Biochemistry - Bachelor of Science and teaching. These degrees are also an excellent preparation for Chemistry - Bachelor of Science professional studies in medicine, dentistry, forensics, veterinary science, optometry, pharmacology, pharmacy and law. Master Degree(s) Chemistry majors who have completed the requirements for the Bachelor Chemistry - Master of Science of Science degree may receive American Chemical Society certification if they take one additional one-semester course which includes 1 credit of Doctoral Degree(s) laboratory. Chemistry - Doctor of Philosophy

All departmental and nondepartmental requirements may not be taken S/ U and must earn a C- or better final grade. Minors for the Department Biochemistry - Undergraduate Minor This department does not have a foreign language requirement for any of its degrees. Chemistry - Undergraduate Minor Graduate Program Information Shelley Lusetti, Department Head The Department of Chemistry and Biochemistry offers programs leading Professors Arterburn, Herndon, Lyons, Rayson; Associate Professors to the MS and Ph.D. degrees in Chemistry in the areas of physical, Ashley, Houston, Lusetti, Maio, Yukl; Assistant Professors Baker, Carlisle, organic, inorganic, biological, and analytical chemistry. Admission Talipov, Windorff; College Associate Professor Dunlavy, College Assistant to these programs without deficiency is based on an undergraduate Professors Chinnasamy, Potenza; Emeritus Professors Eiceman, Gopalan, program essentially equivalent to that pursued by a chemistry or Johnson, Kuehn, Lara, Quintana, Smirnov biochemistry major at this university. All applying students must submit S. Lusetti, Department Head, Ph.D. (Wisconsin–Madison)– biochemistry; undergraduate transcripts, a personal statement and CV, and arrange for enzymology of DNA repair; J. B. Arterburn, Ph.D. (Arizona)– organic 3 letters of recommendation. All foreign students from undergraduate chemistry; synthetic medicinal and chemical biology; A. K. Ashley, Ph.D. programs taught in a language other than English must additionally (Colorado State)– biochemistry and toxicology; DNA replication and repair, submit TOEFL or IELTS scores and demonstrate adequate English cancer; C. A. Baker, Ph.D. (Florida State)– analytical chemistry; separation speaking and writing skills. science, micro- and nanotechnologies for neuroscience and astrobiology; The core course work required of students entering with no S. M. Carlisle, Ph.D. (Louisville)– biochemistry; bioinformatics, cancer previous graduate study in chemistry or biochemistry consists of and metabolic disease; J. W. Herndon, Ph.D. (Princeton)– organic chemistry; courses exploring the concepts of Energy, Structure, Dynamics, and organo-transition metal complexes, synthesis of biologically important cyclic Measurements as applied to all disciplines of chemistry and biochemistry compounds; K. D. Houston, Ph.D. (Texas- MD Anderson)– biochemistry; as well as short courses in Safety, Research Ethics, and Professional molecular mechanisms of hormone action in tumorigenesis; B. A. Lyons, Development. Successful completion of a Qualifying Exam taken after Ph.D. (Cornell)– physical biochemistry; NMR spectroscopic studies of the first year of coursework will determine whether a student is qualified signal transduction pathways in breast cancer; W. A. Maio, Ph.D. (Johns to pursue continued study at the M.S. or Ph.D. level. Ph.D. candidates Hopkins)– organic chemistry; total synthesis of marine natural products and must take at least 6 additional credits of specialized coursework chosen explorations of new chemical methods; G. D. Rayson, Ph.D. (Texas-Austin)– in consultation with the thesis committee while M.S. candidates must analytical chemistry, spectroscopy; M. R. Talipov, Ph.D. (Bashkir State)– take at least 3 additional credits. Ph.D. candidates must successfully Theoretical Physical Chemistry; electronic structure calculations, ab initio complete a Comprehensive Exam in order to be eligible to write and calculations, density functional theory calculations; C. J. Windorff, Ph.D. defend a Ph.D. thesis. All students are expected to participate in (UC-Irvine)- inorganic chemistry; organometallic f-element and transition discussion groups and department colloquia. metal chemistry, redox chemistry; E. T. Yukl, Ph.D. (Oregon Health and Science)– biochemistry; x-ray crystallography and spectroscopy of bacterial Since research is central in both the M.S. and Ph.D. programs, the early metalloproteins selection of a research advisor is encouraged. Students may choose to rotate through up to 3 research labs during their first semester Biochemistry Courses before selecting a research advisor. Financial support is provided to all BCHE 140. Introduction to Biochemistry graduate students during their first year through teaching assistantships. 1 Credit (1) Continued support may be provided through a research or teaching A description of the nature of inquiry in biochemistry, especially with assistantship, depending upon individual laboratory funding. All support respect to the interaction of chemistry and biology. Both historical is contingent upon satisfactory academic and research performance. In development and topics of current interest will be discussed. Graded S/U. addition, numerous traineeships and fellowships are available to qualified 2 Chemistry and Biochemistry

BCHE 241. Introduction to Research in Biochemistry BCHE 424. Experimental Biochemistry I 1-3 Credits 3 Credits (1.25+6P) Techniques and procedures of biochemical research. May be repeated for Laboratory techniques required for experimentation with recombinant a maximum of 3 credits. DNA such as nucleic acid isolation and purification, polymerase chain Prerequisites: 8 credits of chemistry and 3.0 GPA in chemistry. reaction (PCR), sequence analysis, and directed mutagenesis using genetic material from both prokaryotic and eukaryotic organisms. BCHE 341. Survey of Biochemistry 4 Credits (3+3P) Prerequisite(s): C- or better in BCHE 395, and BCHE 396 or GENE 315. Basic principles of biochemical processes and the structure/function Learning Outcomes 1. Conduct experiments safely of the major classes of biomolecules, with introductions to metabolism and the central dogma of biochemistry. The chemical and biological 2. Select and manipulate plasmids to achieve desired recombinant DNA properties of major biomolecules (DNA, proteins, May be repeated up to 4 for experimentation credits. 3. Obtain relevant DNA sequence information for gene of interest from Prerequisite(s): C- or better in CHEM 2115 or CHEM 314. public databases BCHE 395. Biochemistry I 4. Make buffers and reagents necessary for transforming and isolating 3 Credits (3) plasmid DNA from E. coli Principles governing chemistry and physics of life processes with 5. Transform and isolate plasmid DNA to be used for cloning of gene of emphasis on the relationships between molecular structure and cell interest function. Basic principles of biochemical processes, enzymology, 6. Design primers for PCR to enrich gene of interest from genomic DNA and the structure/function of the major classes of biomolecules with 7. Analyze DNA sequence and choose appropriate restriction enzymes introductions to metabolism. Introduction to catabolic metabolism. for cloning gene of interest Prerequisite(s): C or better in CHEM 314. 8. Design primers for PCR to incorporate restriction sites at the ends of BCHE 396. Biochemistry II gene of interest 3 Credits (3) 9. Perform restriction digest on plasmid DNA and PCR products Introduction to anabolic metabolism and hormonal regulation. 10. 1 Perform ligation reaction to combine gene of interest with plasmid Biochemical principles of the mechanism and regulation of replication, DNA transcription, recombination and translation in prokaryotes and eukaryotes. Introduction to DNA-based information technology. Taught 11. 1 Analyze sequence of plasmid containing gene of interest to validate with BCHE 396 H. the outcome of experimentation Prerequisite(s): C or better in BCHE 395. BCHE 425. Experimental Biochemistry II BCHE 396 H. Biochemistry II Honors 3 Credits (3) 3 Credits (3) Introduction to fundamental techniques used to explore structure Taught with BCHE 396 with additional work required. and function of biological macromolecules such as proteins, carbohydrates, lipids, and nucleic acid. Course covers analyzing and reporting experimental data; enzymology; quantitative methods to determine biological molecules; basic principles of electrophoresis, chromatography, and spectroscopic immunochemistry. May be repeated up to 3 credits. Prerequisite(s): C- or better in BCHE 424. Learning Outcomes 1. Understand and implement various methods of protein purification as well as qualitative and quantitative analysis of protein preparations 2. Become proficient in absorbance and fluorescence spectroscopy 3. Determine ligand binding parameters 4. Understand and measure enzyme kinetics and inhibition 5. Perform basic protein crystallization and structure determination 6. Develop skills in scientific writing and presentation Chemistry and Biochemistry 3

BCHE 432. Physical Biochemistry BCHE 590. Discussions in Biochemistry 3 Credits (3) 1 Credit (1) This course focuses on modern Biophysical techniques used in protein Current research problems in biochemistry. May be repeated for a and nucleic acid research. Topics are covered in some detail at the maximum of 6 credits. Graded: S/U Grading (S/U, Audit). theoretical level. The course content is delivered entirely by podcast. BCHE 598. Special Research Programs Podcast contributions are from several different faculty from within their 1-3 Credits particular area(s) of expertise. Topics covered include (but are not limited May be repeated for a maximum of 6 credits. Same as CHEM 598. Graded to): biomolecular NMR, atomic force microscopy, light scattering, circular S/U. dichroism, ultracentrifugation, isothermal titration calorimetry, positron emission tomography, computerized tomography, ultrasound, functional BCHE 599. Master's Thesis MRI, protein fluorescence, mass spec/ proteomics, protein molecular 15 Credits dynamics simulations, and X-ray diffraction. Course credit qualifies for May be repeated for a maximum of 6 credits. Same as CHEM 599. minor degree in chemistry as a physical-analytical chemistry emphasis. BCHE 600. Research CHEM 431, or CHEM 433. 1-15 Credits Prerequisite(s): One semester of undergraduate physical chemistry, e.g. May be repeated for a maximum of 20 credits. PR/U grading. Same as BCHE 440. Biochemistry Seminar CHEM 600. 1 Credit (1) BCHE 647. Physical Biochemistry Introduction to current literature in biochemistry and molecular biology. 3 Credits (3) Selected topics in the field will be presented by the faculty. Students will Fundamental applications of physical chemistry to the investigation present written and oral reports from literature searches. Restricted to: of biological metabolites and biological macromolecules, including BCHE majors. proteins, oligo-nucleotides, and molecular arrays with an emphasis on Prerequisite(s): BCHE 395. understanding biological functions based on chemical structures. Taught BCHE 441. Advanced Research in Biochemistry with BCHE 451. 1-3 Credits Prerequisite(s): 'C' or better in CHEM 431 or CHEM 433 or BCHE 542. Investigation of biochemical problems and the development of special BCHE 649. Topics in Biochemistry techniques. May be repeated for a maximum of 3 credits. 1-3 Credits Prerequisites: consent of instructor, 16 credits of chemistry and 3.0 GPA Selected topics of current interest designated by title and credit. May be in chemistry for nonmajors. repeated for a maximum of 3 credits. BCHE 451. Special Topics BCHE 650. Advanced Seminar 1-3 Credits 1 Credit (1) Same as CHEM 451. May be repeated for a maximum of 12 credits. Discussion of biochemical research in progress that relates to a doctoral Prerequisite: consent of instructor. candidate's thesis research. Intended for students who have earned a BCHE 455. Independent Studies master's degree or the equivalent and has made significant research 1-3 Credits progress for preparation of the doctoral dissertation. May be repeated for Independent studies directed by consulting faculty. a maximum of 3 credits. Prerequisite: consent of instructor. BCHE 700. Doctoral Dissertation BCHE 540. Seminar in Biochemistry 20 Credits 1 Credit (1) May be repeated for a maximum of 20 credits. Graded PR/U. Same as Formal seminar presentation in current topics in biochemical research. CHEM 700. May be repeated for a maximum of 3 credits. BCHE 542. Biochemistry I Chemistry Courses 3 Credits (3) CHEM 1111. Basic Chemistry Relationship between macromolecular structure and function. Basic 3 Credits (3) enzymology. Energy metabolism. For students whose preparatory science or math training has been Prerequisite(s): CHEM 314 and CHEM 431 or CHEM 433; or BCHE 395 or deficient. Does not meet the chemistry requirement in any curriculum. equivalent. Prerequisite: Enhanced ACT composite score of at least 18 or a grade of C- or better in CCDM 114 N. BCHE 545. Molecular and Biochemical Genetics Learning Outcomes 3 Credits (3) 1. The goals and objectives for CHEM 1111 are to equip students An accelerated treatment of the molecular basis of gene expression. with the necessary problem solving skills to be successful in Discussion of chemical, enzymological, and genetic techniques of CHEM 1215G/1225G molecular biology. Same as BIOL 545. Prerequisite: BCHE 542 or equivalent. BCHE 546. Biochemistry II 3 Credits (3) Intermediary metabolism: catabolic and anabolic pathways of carbohydrates, lipids, amino acids, and nucleic acids, including their regulation. Prerequisite: BCHE 542 or BCHE 395 with consent of instructor. 4 Chemistry and Biochemistry

CHEM 1120G. Introduction to Chemistry Lecture and Laboratory (non CHEM 1121. General Supplemental Instruction I majors) 1 Credit (1) 4 Credits (3+3P) Collaborative workshop for students in General Chemistry I. Course does This course covers qualitative and quantitative areas of non-organic not count toward departmental degree requirements. May be repeated for general chemistry for non-science majors and some health professions. a maximum of 2 credits. Students will learn and apply principles pertaining, but not limited to, Corequisite(s): CHEM 1215G. atomic and molecular structure, the periodic table, acids and bases, CHEM 1122. General Supplemental Instruction II mass relationships, and solutions. The laboratory component introduces 1 Credit (1) students to techniques for obtaining and analyzing experimental Collaborative workshop for students in General Chemistry II. Course does observations pertaining to chemistry using diverse methods and not count toward departmental degree requirements. May be repeated for equipment. a maximum of 2 credits. Prerequisite: CCDM 114N or A S 103 or MATH 1215 or higher. Corequisite(s): CHEM 1225G. Learning Outcomes 1. (Lecture) Use the different systems of measurements and perform CHEM 1123. Principles of Supplemental Instruction III conversions within the same system of measurement and between 1 Credit (1) different systems of measurements Collaborative workshop for students in CHEM 1120G, Principles and 2. (Lecture) Identify elements from their name or symbol, use the Applications of Chemistry. Course does not count toward departmental periodic table to describe reactivity patterns of elements and to degree requirements. May be repeated for maximum of 2 credits. predict compound formation. Corequisite(s): CHEM 1120G. 3. (Lecture) Describe the basic structure of an atom using subatomic particles, and apply these concepts to nuclear reactions. 4. (Lecture) Describe ion formation and the difference between covalent and ionic compounds. Name and write formulas for ionic and simple molecular compounds. 5. (Lecture) Write and balance chemical reactions. Use balanced reactions in stoichiometric calculations. 6. (Lecture) Describe the differences between the solid, liquid and gas phases. Use the gas laws in calculations, and apply these laws to everyday situations. 7. (Lecture) Explain different types of energy, and how energy is released or absorbed in a reaction 8. (Lecture) Describe acid and base behavior. 9. (Lecture) Explain the intermolecular attractive forces that determine physical properties; apply this knowledge to qualitatively evaluate these forces and predict the physical properties that result. 10. 1(Lecture) Explain the intermolecular attractive forces that determine physical properties; apply this knowledge to qualitatively evaluate these forces and predict the physical properties that result 11. 1(Laboratory) Practice concepts associated with laboratory safety, including the possible consequences of not adhering to appropriate safety guidelines. 12. 1(Laboratory) Demonstrate the computational skills needed to perform appropriate laboratory- 13. related calculations to include, but not be limited to determining the number of significant figures in numerical value, solving problems using values represented in exponential notation, solving dimensional analysis problems, and manipulating mathematical formulas as needed to determine the value of a variable. 14. 1(Laboratory) Perform laboratory observations (both qualitative and quantitative) using sensory experience and appropriate measurement instrumentation (both analog and digital). 15. 1(Laboratory) Record quantitatively measured values to the correct number of significant figures and assign the correct units. 16. 1(Laboratory) Master basic laboratory techniques including, but not limited to weighing samples (liquid and solid), determining sample volumes, measuring the temperature of samples, heating and cooling a sample or reaction mixture, decantation, filtration, and titration. 17. 1(Laboratory) Draw appropriate conclusions based on data and analyses. 18. 1Present experimental results in laboratory reports of appropriate length, style and depth, or through other modes as required. 19. 1Determine chemical formulas and classify different types of reactions. 20. 1Relate laboratory experimental observations, operations, calculations, and findings to theoretical concepts presented in the complementary lecture course. Chemistry and Biochemistry 5

CHEM 1215G. General Chemistry I Lecture and Laboratory for STEM CHEM 1216. General Chemistry I Lecture and Laboratory for CHEM Majors Majors 4 Credits (3+3P) 4 Credits (3+3P) This course covers descriptive and theoretical chemistry. As the first of a two-semester sequence, this course teaches fundamental Prerequisite: (1) grade of C- or better in MATH 1215 or higher, or a concepts in chemistry, including the electronic structure of atoms, Mathematics Placement Exam Score adequate to enroll in mathematics chemical periodicity, nature of chemical bonds, molecular structure, courses beyond MATH 1215. the three phases of matter, etc. Designed for majors in chemical and Learning Outcomes other physical sciences, including engineering. May be appropriate for 1. Use dimensional analysis, the SI system of units and appropriate the life science major. It is assumed that the students are familiar with significant figures to solve quantitative calculations in science. college algebra, chemical nomenclature, stoichiometry, and scientific Understand the differences between physical and chemical changes measurements. The laboratory component is designed to complement to matter. Classify types of matter. Understand the scientific method the theory and concepts presented in lecture, and will introduce students in the context of scientific discoveries. Explain the structure of to techniques for obtaining and analyzing experimental observations atoms, isotopes and ions in terms of subatomic particles. Analyze pertaining to chemistry using diverse methods and equipment. how periodic properties (e.g. electronegativity, atomic and ionic Prerequisite(s): Eligible to take MATH 1250G and an ACT composite radii, ionization energy, electron affinity, metallic character) and score of 22 or higher. reactivity of elements results from electron configurations of Learning Outcomes atoms. Understand the creation of different types of compounds 1. Apply the mole concept to amounts at a microscopic level and use (ionic and molecular), comparing and contrasting their structures, this to perform stoichiometric calculations for reactions in solution, naming schemes and formulas. Apply knowledge of electronic gases and thermochemistry. Calculate solution concentrations in structure to determine molecular spatial arrangement and polarity. various units. Apply the gas laws and kinetic molecular theory to Understand bulk pure substances, their properties and their states relate atomic level behavior to macroscopic properties. Explain of matter by understanding and identifying intermolecular forces. the electronic structure of atoms, isotopes and ions in terms of Apply kinetic molecular theory to relate atomic level behavior to its subatomic particles. Analyze how periodic properties (e.g. macroscopic properties. Introduce the mole and apply the mole electronegativity, atomic and ionic radii, ionization energy, electron concept to amounts on a macroscopic and a microscopic level affinity, metallic character) and reactivity of elements results from Understand mixtures, solubility by considering intermolecular electronic configurations of atoms. Understand the nature of forces and expressing concentration in molarity. Identify different chemical bonds (ionic and covalent). Apply knowledge of electronic reaction types. Apply the law of conservation of mass to reactions. structure to determine molecular structure and polarity. Understand Perform stoichiometry on balanced reactions. Laboratory Student the formation of different phases of matter and the underlying Learning Outcomes Demonstrate and apply concepts associated fundamental intermolecular interactions. Describe physical states with laboratory safety, including the possible consequences of and changes, and distinguish these from chemical changes. Describe not adhering to appropriate safety guidelines. Demonstrate the the energy conversions that occur in chemical reactions and state computational skills needed to perform appropriate laboratory changes, relating heat of reaction to thermodynamic properties such related calculations to include, but not be limited to determining as enthalpy and internal energy; apply these principles to measure the number of significant figures in numerical value with the correct and calculate energy changes in reaction. 1 Apply principles of units, solving problems using values represented in exponential general chemistry to specific real-world problems in environment, notation, solving dimensional analysis problems, and manipulating engineering and health-related fields. mathematical formulas as needed to determine the value of a variable. Perform laboratory observations (both qualitative and quantitative) using sensory experience and appropriate measurement instrumentation (both analog and digital). Prepare solutions with an acceptable accuracy to a known concentration using appropriate glassware. Master basic laboratory techniques including, but not limited to weighing samples (liquid and solid), determining sample volumes, measuring the temperature of samples, heating and cooling a sample or reaction mixture, decantation, filtration, and titration. Draw conclusions based on data and analyses from laboratory experiments. Relate laboratory experimental observations, operations, calculations, and findings to theoretical concepts presented in the complementary lecture course. 6 Chemistry and Biochemistry

CHEM 1225G. General Chemistry II Lecture and Laboratory for STEM CHEM 1226. General Chemistry II Lecture and Laboratory for CHEM Majors Majors 4 Credits (3+3P) 4 Credits (3+3P) This course is intended to serve as a continuation of general chemistry As the second of a two-semester sequence, this course teaches principles for students enrolled in science, engineering, and certain fundamental concepts in chemistry, including solutions, equilibria, preprofessional programs. The course includes, but is not limited to a electrochemistry, thermodynamics and kinetics. Designed for majors theoretical and quantitative coverage of solutions and their properties, in chemical and other physical sciences, including engineering. May be kinetics, chemical equilibrium, acids and bases, entropy and free energy, appropriate for the life science major. It is assumed that the students electrochemistry, and nuclear chemistry. Additional topics may include are familiar with college algebra, chemical nomenclature, stoichiometry, (as time permits) organic, polymer, atmospheric, and biochemistry. and scientific measurements. The laboratory component is designed The laboratory component is designed to complement the theory and to complement the theory and concepts presented in lecture, and concepts presented in lecture, and will introduce students to techniques will introduce students to techniques for obtaining and analyzing for obtaining and analyzing experimental observations pertaining to experimental observations pertaining to chemistry using diverse methods chemistry using diverse methods and equipment. and equipment. Prerequisite(s): C- or better in CHEM 1215G. Prerequisite(s): C- or better in CHEM 1216. Learning Outcomes Learning Outcomes 1. Explain the intermolecular attractive forces that determine physical 1. Describe the colligative properties of solutions and explain them properties and phase transitions, and apply this knowledge to using intermolecular forces. Determine solution concentrations using qualitatively evaluate these forces from structure and to predict the colligative property values and vice versa. Explain rates of reactions, physical properties that result. Calculate solution concentrations rate laws, and half-life; determine the rate, rate law and rate constant in various units, explain the effects of temperature, pressure and of a reaction and calculate concentration as a function of time and structure on solubility, and describe the colligative properties of vice versa. Understand the principle of catalysis. Explain the collision solutions, and determine solution concentrations using colligative model of reaction dynamics, including activation energy, catalysts property values and vice versa. Describe the dynamic nature of and temperature; Derive a rate law from a reaction mechanism and chemical equilibrium, and apply LeChatelier’s Principle to predict evaluate the consistency of a mechanism with a given rate law. the effect of concentration, pressure and temperature changes on Describe the dynamic nature of chemical equilibrium and its relation equilibrium mixtures as well as describe the equilibrium constant to reaction rates; apply Le Chatelier’s Principle to predict the effect and use it to determine whether equilibrium has been established, of concentration, pressure and temperature changes on equilibrium and calculate equilibrium constants from equilibrium concentrations mixtures. Describe the equilibrium constant and use it to determine and vice versa. Describe the different models of acids and base whether equilibrium has been established; calculate equilibrium behavior and the molecular basis for acid strength, as well as apply constants from equilibrium concentrations (including pressures) and equilibrium principles to aqueous solutions, including acid/base and vice versa. Describe the different models of acids and base behavior, solubility reactions, and calculate pH and species concentrations and the molecular basis for acid strength. in buffered and unbuffered solutions. Explain titration curves as well as calculate concentrations of reactants. Explain and CHEM 2111. Explorations in Chemistry calculate the thermodynamic functions, enthalpy, entropy and Gibbs 1 Credit (1) free energy, for a chemical system, and relate these functions to The major intent of this course is to deepen your interest in chemistry equilibrium constants Student Learning Outcomes – Laboratory and make you aware of research and career opportunities in the Demonstrate and apply concepts associated with laboratory safety, field. During this semester we hope to discuss both old and new including the possible consequences of not adhering to appropriate developments in chemistry that impact our lives. We also want to build safety guidelines. Demonstrate the computational skills needed our communication skills that are so necessary in our profession. Graded to perform appropriate laboratory related calculations to include, S/U. but not be limited to determining the number of significant figures in numerical value with the correct units, solving problems using values represented in exponential notation, solving dimensional analysis problems, and manipulating mathematical formulas as needed to determine the value of a variable. Perform laboratory observations (both qualitative and quantitative) using sensory experience and appropriate measurement instrumentation (both analog and digital). Prepare solutions with an acceptable accuracy to a known concentration using appropriate glassware. Perform basic laboratory operations related to, but not limited to, colligative properties of solutions, chemical equilibria, acid/base titrations, electrochemistry. Draw conclusions based on data and analyses from laboratory experiments. Relate laboratory experimental observations, operations, calculations, and findings to theoretical concepts presented in the complementary lecture course. Chemistry and Biochemistry 7

CHEM 2115. Survey of Organic Chemistry and Laboratory CHEM 2226. General Chemistry III 4 Credits (3+3P) 3 Credits (2+3P) This course is a one -semester survey of organic and biological Quantitative aspects of general chemistry: solid state structure, chemicals. Students will be introduced to nomenclature, molecular equilibrium, thermodynamics, and kinetics. Required of chemical science structure, properties, and reactions of hydrocarbons, alcohols, carbonyls, majors who have taken CHEM 1215G/1225G. organic acids and bases, carbohydrates, lipids, and proteins. The Prerequisite: CHEM 1225G. handling of organic chemicals, simple organic reactions, tests for Learning Outcomes functional groups, and synthesis will be learned in the laboratory 1. describe the process of scientific inquiry component of this course. May be repeated up to 4 credits. 2. solve problems scientifically Prerequisite(s): CHEM 1225G. 3. communicate scientific information Learning Outcomes 4. apply quantitative analysis to scientific problems 1. Identify common organic functional groups. 5. apply scientific thinking to real world problems 2. Translate between the IUPAC names and structures of simple organic molecules. CHEM 2991. Introduction to Research 3. Predict the products of certain organic chemical reactions from 1-3 Credits (3+9P) reagents and conditions presented. Techniques and procedures of chemical research. May be repeated for a 4. Predict physical and chemical behavior of organic molecules based maximum of 3 credits. on structure. Prerequisites: 8 credits of chemistry and a 3.0 GPA in chemistry. 5. Synthesize several classes of organic compounds in the laboratory Learning Outcomes that were previously studied in the lecture component of this course. 1. Varies 6. Recognize and name the four basic bioorganic units and certain of CHEM 2996. Special Topics in Chemistry their derivatives and macromolecules. 1-6 Credits (1-6) 7. Construct 3 dimensional models of organic compounds. Specific subjects in Chemistry. These subjects will be announced in the 8. Understand and apply safety principles associated with Organic 'Schedule of Classes'. It may be repeated under different topics for a Chemistry laboratory operations and activities. maximum of 12 credits. 9. Present experimental results in laboratory reports of appropriate Learning Outcomes length, style and depth, or through other modes as required. 1. Varies 10. 1Draw/recognize stereochemistry and explain its relevance to bioorganic molecules. CHEM 303. Organic Supplemental Instruction I 1 Credit (1) CHEM 2120. Integrated Organic Chemistry and Biochemistry Collaborative workshop for students in Organic Chemistry I. Course does 3 Credits (3) not count toward departmental degree requirements. May be repeated for This course is a one- semester introduction to Organic Chemistry a maximum of 2 credits. and Biochemistry designed for students in health and environmental Corequisite(s): CHEM 313. occupations. The course surveys organic compounds in terms of CHEM 304. Organic Supplemental Instruction II structure, physical, and chemical properties, followed by coverage of the 1 Credit (1) chemistry of specific classes of organic compounds in the biological Collaborative workshop for students in Organic Chemistry II. Course does environment. Students will apply course concepts to everyday organic not count toward departmental degree requirements. May be repeated for and biological chemistry problems in preparation for careers in health a maximum of 2 credits. and environmental fields. Corequisite(s): CHEM 314. Prerequisite: CHEM 1120G or CHEM 1215G. CHEM 313. Organic Chemistry I Learning Outcomes 3 Credits (3) 1. Identify and name basic organic compounds. Nomenclature, uses, basic reactions, and preparation methods of the 2. Construct/draw organic compounds from the names. most important classes of aliphatic and aromatic compounds. 3. Predict the products of certain organic chemical reactions from Prerequisite(s): C- or better in CHEM 1225G or CHEM 1226. reagents and conditions presented. 4. Recognize and name the four basic bioorganic units and certain of their derivatives and macromolecules. 5. Compare and contrast the function and location of the four bioorganic units and their macromolecules and cofactors. 6. Draw/recognize stereochemistry and explain its relevance to bioorganic molecules. 7. Discuss the pathways and functions of some of the cellular metabolic processes. 8. Recognize and describe metabolic cellular processes and macromolecular structure with respect to health and/or disease state 8 Chemistry and Biochemistry

CHEM 314. Organic Chemistry II CHEM 424. Soil Chemistry 3 Credits (3) 3 Credits (3) An in-depth focus on reactions and mechanisms as they relate to Same as SOIL/GEOL 424. organometallic compounds, alcohols, ethers, ketones, aldehydes, CHEM 431. Physical Chemistry carboxylic acid derivatives, an amines. May be repeated up to 3 credits. 3 Credits (3) Prerequisite(s): C- or better in CHEM 313. Principles that govern the physical and chemical behavior of matter. May Learning Outcomes not be counted toward Bachelor of Science degree in Chemistry. 1. Identify several new functional groups and other key features of Prerequisite(s): CHEM 1226 or CHEM 2226; MATH 1521G; PHYS 1240G organic compounds Interpret 1H / 13C NMR, IR, UV-Vis, and Mass or PHYS 2240G or PHYS 2140 or PHYS 1320G. spectrometry data and have the ability to correlate structural elements with spectral features Understand the chemical reactivity CHEM 431 H. Physical Chemistry Honors and reaction mechanisms relating, but not limited, to organometallic 3 Credits (3) compounds, alcohols, ethers, ketones, aldehydes, carboxylic acids, Same as CHEM 431. Additional work to be arranged. and amines. Mechanistic highlights include: etherification, acetal Prerequisite(s): CHEM 1226 or CHEM 2226; MATH 1521G or formation / removal, alcohol oxidation, carbonyl addition reactions, MATH 1521H; PHYS 1240G or PHYS 2240G or PHYS 2140 or enolate (and related) reactions, formation of carboxylic acid PHYS 1320G. derivatives, and nucleophilic acyl substitution processes. Apply these CHEM 433. Physical Chemistry I mechanistic and reactivity considerations to these same groups 3 Credits (3) when they appear as substructures in larger biologically-important Laws and theories underlying chemical phenomena. molecules (e.g. carbohydrates, amino acids, and lipids). Design Prerequisite(s): CHEM 1226 or CHEM 2226; MATH 1521G; PHYS 2140 or concise, three to five step syntheses of simple organic molecules PHYS 1320G, or consent of instructor. using reactions learned in both CHEM 313 and 314 Qualitatively CHEM 433 H. Physical Chemistry I Honors assess stability, solubility properties, chemical reactivity, spectral 3 Credits (3) properties, and potential reactions that would lead to preparation, Same as CHEM 433. Additional work to be arranged. simply via visual inspection of structure. Prerequisite(s): CHEM 1226 or CHEM 2226; MATH 1521G or CHEM 315. Organic Chemistry Laboratory MATH 1521H; PHYS 2140 or PHYS 1320G, or consent of instructor. 2 Credits (6P) CHEM 434. Physical Chemistry II Techniques, preparative and analytical methods in organic chemistry. 3 Credits (3) May be repeated up to 2 credits. Laws and theories underlying chemical phenomena. Prerequisite(s)/Corequisite(s): CHEM 314. Prerequisite(s): C- or better in Prerequisite: CHME 302 or CHEM 433. CHEM 313 or consent of instructor. CHEM 435. Physical Chemistry Laboratory CHEM 351. Special Topics 2 Credits (6P) 1-3 Credits Prerequisite: concurrent registration in CHEM 434. Specific subjects to be announced in the Schedule of Classes. May be CHEM 441. Advanced Research repeated for a maximum of 12 credits. 1-3 Credits (3+9P) Prerequisite: consent of instructor. Investigation of chemical problems and the development of special CHEM 356. Descriptive Inorganic Chemistry techniques. May be repeated for a maximum of 3 credits. 3 Credits (3) Prerequisites: consent of instructor, 16 credits of chemistry and 3.0 GPA Occurrence and properties of the elements and the chemistry of their in chemistry for nonmajors. compounds. CHEM 443. Senior Seminar Prerequisite(s): (CHEM 1225G or CHEM 1226) and (CHEM 2115 or 1 Credit (1) CHEM 313). Discussions of current chemical research, impact of chemistry on society CHEM 357. Synthetic Inorganic Laboratory and/or ethics as applied to chemists. Each student will present a written 2 Credits (6P) and an oral report on an approved topic. Explores synthesis and analysis of main group and transition metal Prerequisite: CHEM 431 or CHEM 433. inorganic compounds. Inorganic laboratory and spectroscopic CHEM 451. Special Topics techniques will be used. 1-3 Credits Prerequisites: CHEM 356. Specific subjects to be announced in the Schedule of Classes. May be CHEM 371. Analytical Chemistry repeated for a maximum of 12 credits. 4 Credits (2+6P) Prerequisite: consent of instructor. The fundamentals of quantitative chemical analysis. CHEM 455. Independent Studies Prerequisite(s): C- or better in CHEM 1225G or CHEM 1226. 1-3 Credits CHEM 422. Environmental Chemistry Independent studies directed by consulting faculty. 3 Credits (3) Prerequisite: consent of instructor. Chemistry of organic and metal ion pollutants in the environment and CHEM 456. Inorganic Structure and Bonding principles important to their remediation including bioremediation. 3 Credits (3) Restricted to: Main campus only. Crosslisted with: ENVS 422 Theoretical principles and a systematic study of the periodic table. Prerequisite(s): CHEM 1225G and either CHEM 2115 or CHEM 313. Prerequisite: CHEM 356 or CHEM 431 or CHEM 433. Chemistry and Biochemistry 9

CHEM 466. Advanced Organic Chemistry CHEM 503. Central Concepts in Chemistry - Dynamics 3 Credits (3) 3 Credits (3) Recent developments in synthesis and theoretical principles of organic This course will provide the students with a detailed examination of chemistry. several topics in chemical reactivity. These topics include: (1) basic Prerequisite: CHEM 314. kinetic concepts, (2) fundamental gas phase kinetics (3) organic, inorganic and biochemical reaction mechanisms. CHEM 471. Instrumental Methods of Analysis 4 Credits (3+3P) Learning Outcomes 1. Students who successfully complete this course will understand the Analytical techniques, including optical and procedures. fundamentals of chemical dynamics: from simple gas or solution Prerequisites: CHEM 371 and either PHYS 1240G or PHYS 1320G. phase reaction mechanisms to biomolecular interactions. CHEM 475. Central Concepts in Chemistry - Safety 1 Credit (1) CHEM 504. Central Concepts in Chemistry - Measurements Students will obtain university safety training plus departmental-specific 3 Credits (3) safety guidelines for the research laboratory This course will provide the students with a detailed examination of Learning Outcomes several topics in chemical measurements. These topics include: (1) 1. Students completing this course will be knowledgeable of all safety spectroscopic, electrochemical and chromatographic techniques, guidelines delineated by the University, College, and Department. (2) statistical methods of measurement and validation relevant to 2. When possible accident case-studies will be incorporated within the biomolecules, synthetic polymers and mixtures. curriculum. Learning Outcomes 1. The collection of quantitative data is central to all subdisciplines of CHEM 476. Central Concepts in Chemistry - Research Ethics chemistry. 1 Credit (1) 2. Students completing this course will understand the basic principles Students will complete Federal Agency (NSF, NIH, etc.) on-line training of chemical measurements and the uncertainties inherently modules in responsible conduct in research and discuss relevant case- associated with those measurements. studies of research misconduct. 3. They will also gain knowledge of tools available to minimize those Learning Outcomes uncertainties in data interpretation. 1. Completion of this class will yield researchers fully aware of federal and professional guidelines regarding the ethical conduction and CHEM 507. Chemistry of the Elements dissemination of data and conclusions. 3 Credits (3) Discussion of the reactions and structures of inorganic compounds. CHEM 477. Central Concepts in Chemistry - ProfessionalDevelopment 1 Credit (1) CHEM 510. Graduate Student Seminar Students will receive basic instruction in research dissemination 1 Credit (1) strategies (presentations) and career planning. Research seminar for graduate students in Chemistry. Enrollment required each semester for all graduate students. Masters or Doctoral CHEM 501. Central Concepts in Chemistry - Energy candidates presenting a research seminar enroll for a letter grade. All 3 Credits (3) other participating students enroll using the S/U grading option. This course will provide the students with a detailed examination of Learning Outcomes several topics in chemical energetics. These topics include: (1) basic 1. Graduate students will gain experience organizing a research thermodynamics concepts, (2) statistical thermodynamics (3) chemical presentation. Graduate students will develop oral presentation skills. equilibria, and (4) intermolecular interactions. Learning Outcomes CHEM 514. Organic Structure Determination 1. Students completing this course will gain an understanding of 3 Credits (3) chemical thermodynamics and equilibria as they relate to all areas of Modern spectroscopic techniques for characterization of organic chemistry. compounds.

CHEM 502. Central Concepts in Chemistry - Structure CHEM 515. Modern Organic Chemistry 3 Credits (3) 3 Credits (3) This course will provide the students with a detailed examination of Recent developments in synthesis and theoretical principles of organic several topics in chemical reactivity. These topics include: (1) principles chemistry. of chemical bonding and (2) organic, inorganic and biochemical structure CHEM 516. Physical Organic Chemistry determination. 3 Credits (3) Learning Outcomes Physical organic chemistry. 1. Students completing this course will understand the fundamental components of molecular interactions and their impact on molecular structure and function in all areas of chemistry. 2. In addition, they will learn the theory and practice of physical techniques used to determine molecular structure. 10 Chemistry and Biochemistry

CHEM 520. Comprehensive Literature Review Seminar for Graduate CHEM 629. Advanced Topics in Analytical Chemistry Students 3 Credits (3) 1 Credit (1) Discussion of advanced topics in the field of analytical chemistry. May be Graduate student presents a literature review on an approved topic. The repeated with different subtitles. Consent of instructor required. seminar presentation will include cover new developments of primary CHEM 639. Topics in Physical Chemistry significance to the topic based on current research papers and culminate 1-3 Credits in a testable hypothesis. A passing grade allows the student to take the Selected topics of current interest designated by subtitle. comprehensive exam. Learning Outcomes CHEM 700. Doctoral Dissertation 1. Student will prepare an abstract of their presentation understandable 17 Credits to a broad chemistry/biochemistry audience Student will Dissertation preparation. demonstrate a reasonable understanding of every concept introduced

Student will present a well-organized topic leading to a logical Phone: (575) 646-2505 hypothesis Student will demonstrate the ability to develop a data- supported hypothesis Email: [email protected]

CHEM 521. Chemical Instrumentation Website: https://chemistry.nmsu.edu 3 Credits (2+3P) Theory and application of electronic devices to chemical analysis. CHEM 526. Advanced Analytical Chemistry 3 Credits (3) Equilibria, and the theories of gravimetric, volumetric, and instrumental analysis. CHEM 527. Separations 3 Credits (3) Covers the fundamentals of separation methods and relationships to modern analytical techniques such as gas chromatography and liquid chromatography. CHEM 529. Spectrochemical Analysis 3 Credits (3) Fundamentals, instrumentation, and applications of spectrochemical analysis. CHEM 536. Chemical Thermodynamics 3 Credits (3) First, second, and third laws of thermodynamics, and the concepts, interrelations, and applications of thermodynamic state functions. CHEM 537. Quantum Chemistry 3 Credits (3) Fundamentals of quantum mechanics. Prerequisite: consent of instructor. CHEM 538. Chemical Kinetics 3 Credits (3) Empirical analysis of rate measurements, collision theory, transition state theory, and chain reactions. CHEM 598. Special Research Programs 1-3 Credits Individual investigations, either analytical or experimental. Graded S/U. CHEM 599. Master's Thesis 15 Credits Thesis preparation. CHEM 600. Research 1-15 Credits Course used for assigning credit for research performed prior to successful completion of the doctoral qualifying examination. CHEM 619. Topics in Organic Chemistry 1-3 Credits Selected topics of current interest designated by subtitle.