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Salk Bulletin Monday, July 18, 2016 Monday, July 18, 2016 4:00 pm “Brain-Immune Crosstalk in Neuropsychiatric Conditions: Current Evidence and Future Directions” Suzi Hong, Ph.D., Associate Professor, Department of Psychiatry UNIVERSITY OF CALIFORNIA, SAN DIEGO Biomedical Sciences Building (BSB), 2071 Contact: Carla Ingle, [email protected] Tuesday, July 19, 2016 Tuesday, July 19, 2016 12:00 pm “Memory T Cell Subsets in Protective and Pathogenic Immune Responses” 1 Federica Sallusto and Antonio Lanzavecchia, Institute for Research in Biomedicine, Bellinzona, Switzerland LA JOLLA INSTITUTE FOR ALLERGY AND IMMUNOLOGY Ishizaka Seminar Room Hosts: Alessandro Sette and Bjoern Peters Wednesday, July 20, 2016 Wednesday, July 20, 2016 12:00 pm “The Aging and Turnover of Secreted Proteins in Sepsis and Intestinal Inflammation” Jamey Marth, Ph.D., Carbon Professor of Biochemistry and Molecular Biology, Mellichamp Professor of Systems Biology, University of California, Santa Barbara LA JOLLA INSTITUTE FOR ALLERGY AND IMMUNOLOGY Ishizaka Seminar Room Host: Mitchell Kronenberg, Ph.D. Thursday, July 21, 2016 No Seminar Listings At This Time Friday, July 22, 2016 No Seminar Listings At This Time Monday, July 25, 2016 2 No Seminar Listings At This Time Salk Bulletin Extra Saturday, July 30, 2016 8:30 am - 2:00 pm Technology Licensing Workshop UC San Diego Extension Host: UC San Diego Extension Contact: Julia Dunlap, [email protected] Register: http://extension.ucsd.edu/studyarea/index.cfm?vAction=saDetail&vStudyAr eaID=111 August 22-23, 2016 PATRIC Bioinformatics Resource Center Eorkshop Featuring Data and Analysis Tools for Bacterial Genomes and ‘Omics DATA SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE Building 10, Room 1308 Host: Bioinformatics Program at SBP Contact: Andrei Osterman, [email protected] or Cindy Cook, [email protected] Register: Send email to [email protected] Friday, September 9, 2016 9:00 am – 4:30 pm 28th Annual Usha Mahajani Symposium on Molecular Medicine “RNA and Cancer” SALK INSTITUTE FOR BIOLOGICAL STUDIES Conrad T. Prebys Auditorium Hosts: Catriona Jamieson, M.D., Ph.D., Clodagh O'Shea, Ph.D., Robert J. Wechsler-Reya, Ph.D. Contact: Patti Strasberg, [email protected] Register: www.ccmmeetings.com Thursday, October 6, 2016 5:45 pm Cell & Gene Meeting on the Mesa Public Forum 3 Elena Cattaneo, Ph.D., Full Professor, Laboratory of Stem Cell Biology and Pharmacology of Neurodegenerative Diseases, Department of Biosciences, University of Milan SANFORD CONSORTIUM FOR REGENERATIVE MEDICINE This Public Forum is free to attend. Contact: Laura Parsons, [email protected] Friday, October 7, 2016 8:00 am Cell & Gene Meeting on the Mesa Scientific Symposium Various Speakers -- See Website for Full Listing SALK INSTITUTE FOR BIOLOGICAL STUDIES Organized by: Alliance for Regenerative Medicine (ARM) and Sanford Consortium for Regenerative Medicine Contact: Laura Parsons, [email protected] Registration Now Open: http://meetingonthemesa.com Registration deadline: September 30, 2016 Saturday, November 12, 2016 8:00 am – 2:00 pm Society for Claustrum Research Third Annual Symposium “The Undiscovered Claustrum” SALK INSTITUTE FOR BIOLOGICAL STUDIES Host: Terrence Sejnowski, Ph.D. Contact: Mary Ellen Perry, [email protected], 858-453-4100 x1219 Meeting Website: http://www.salk.edu/events/science-events/the- undiscovered-claustrum/ Register: http://SalkInstitute.kintera.org/Claustrum2016 The Salk Bulletin is brought to you by Salk Events. Please send all questions and submissions to Inger Johnson, at [email protected] 4.

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UC San Diego UC San Diego Electronic Theses and Dissertations
UC San Diego UC San Diego Electronic Theses and Dissertations Title Colitis, hypothyroidism, and immunological alterations in mice deficient in glycan branching enzymes Permalink https://escholarship.org/uc/item/4hk1z8b3 Author Stone, Erica Lyn Publication Date 2009 Peer reviewed|Thesis/dissertation eScholarship.org Powered by the California Digital Library University of California UNIVERSITY OF CALIFORNIA, SAN DIEGO Colitis, Hypothyroidism, and Immunological Alterations in Mice Deficient in Glycan Branching Enzymes. A Dissertation submitted in partial satisfaction of the requirements for the degree Doctor of Philosophy in Biology by Erica Lyn Stone Committee in charge: Professor Jamey D. Marth, Chair Professor Stephen M. Hedrick, Co-Chair Professor Steven F. Dowdy Professor Ananda W. Goldrath Professor Maho Niwa Copyright Erica Lyn Stone, 2009 All rights reserved. The Dissertation of Erica Lyn Stone is approved, and it is acceptable in quality and form for publication on microfilm and electronically: Co-Chair Chair University of California, San Diego 2009 iii To my brother, David Charles Stone. In recognition of all you taught me about life. iv EPIGRAPH Change will not come if we wait for some other person of some other time. We are the ones we’ve been waiting for. We are the change that we seek. Barack Obama v TABLE OF CONTENTS Signature Page……………………………………………………………………. iii Dedication Page…..………………………………………………………………. iv Epigraph…………………………………………………………………………… v Table of Contents…………………………………………………………………. vi List of Figures and Tables.………………………………………………………. ix List of Abbreviations……………………………………………………………… xii Acknowledgments...……………………………………………………………… xiv Curriculum Vita…….……………………………………………………………... xvii Abstract of the Dissertation……………………………………………………… xix General Introduction….…………………………………………………………… 1 I. Figures and Legends…………………………………………………... 11 II. References……….…………………………………………………….. 13 Chapter 1: Biological Functions of Glycosyltransferase Enzymes Critical in Core O-Glycan Biosynthesis………………………………………..
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UCSB Researchers Perform Pioneering Research on Type 2 Diabetes
Gail Gallessich (805) 893-7220 [email protected] George Foulsham (805) 893-3071 [email protected] January 4, 2013 UCSB Researchers Perform Pioneering Research on Type 2 Diabetes (Santa Barbara, Calif.) –– While legions of medical researchers have been looking to understand the genetic basis of disease and how mutations may affect human health, a group of biomedical researchers at UC Santa Barbara is studying the metabolism of cells and their surrounding tissue, to ferret out ways in which certain diseases begin. This approach, which includes computer modeling, can be applied to Type 2 diabetes, autoimmune diseases, and neurodegenerative diseases, among others. Scientists at UCSB have published groundbreaking results of a study of Type 2 diabetes that point to changes in cellular metabolism as the triggering factor for the disease, rather than genetic predisposition. Type 2 diabetes is a chronic condition in which blood sugar or glucose levels are high. It affects a large and growing segment of the human population, especially among the obese. The team of scientists expects the discovery to become a basis for efforts to prevent and cure this disease. The current work is based on a previous major finding by UCSB’s Jamey Marth, who determined the identity of the molecular building blocks needed in constructing the four types of macromolecules of all cells when he was based at the Howard Hughes Medical Institute in La Jolla in 2008. These include the innate, genetic macromolecules, such as nucleic acids (DNA and RNA) and their encoded proteins, and the acquired metabolic macromolecules known as glycans and lipids.
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Principles of Adipobiology: a Gentle Introduction
Adipobiology ISSN 1313-3705 (online) CONTINUING MEDICAL © Bul garian Society for Cell Biology EDUCATION PRINCIPLES OF ADIPOBIOLOGY: A GENTLE INTRODUCTION George N. Chaldakov* Department of Anatomy and Cell Biology, Medical University, Varna, Bulgaria and Institute for Advanced Study, Varna, Bulgaria Figure 1. Schematic view of cell-to-cell interactions via nexuses (gap junctions, channel junctions, communicating junc- tions, macula communicans) between the neibouring Cell A and Cell B, intercellular space of 2 - 4 nm. One channel of nexus is composed of two connexons (or hemichannels). The hexagonal structure of connexons (cross sectioned) consisting of six proteins termed connexins – Cx) is evident; an arrow runs through one of the chanells. One nexus consists of about 100 connexons. (*Grosely R, Sorgen PL. A history of gap junction structure: Hexagonal arrays to atomic resolution. Cell Commun Adhes 2013; 20. DOI:10.3109/15419061.2013.775256 *Wright JA, Richards T, Becker DL. Connexins and diabetes. Cardiol Res Pract 2012; 2012: 496904. DOI:10.1155/2012/496904) *Received 2 June 2019, revised 10 June 2019, accepted 11 June 2019. Correspondence to: Dr George N. Chaldakov, Department of Anatomy and Cell Biology, Medical University, BG-9002 Varna, Bulgaria Mobile phone: +359 888 679 204 E-mail: [email protected] - to keep students-to-teacher communicating junctions alive and kicking (Fig. 1) 114 Principles of adipobiology: a gentle introduction CONTINUING MEDICAL EDUCATION Prologue Introduction Student – Latin, studеo – devoted to do something; studium – The biological research has already provided a wealth of eager, passion, study. knowledge about individual cellular components and their Teacher To be a teacher is profound responsibility.
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UC Santa Barbara
DIRECTIONS TO RATHMANN AUDITORIUM L O T 9 12 P 402 451 Phelps Hall 570 489 M Campbell esa 11 R Hall o a 101 P d Engineering 217 Elings Science Henley 10 Hall Buchanan PSB Chemistry 1179 Gate Ellison Hall Hall North P Engineering Ward II Memorial Campus Green Blvd. Kohn PSB Hall South 615 Davidson MRL Library 406 Broida Hall Harold Frank Lagoon Road Hall Webb Hall Bren Hall 1 P N 7 Noble Hall 3 P P Life Pacific Ocean Sciences Bio Psych II UCEN Road 9 P UC Santa Barbara UNIVERSITY OF CALIFORNIA JAMEY MARTH joined the Department of Molecular, Cellular SANTA BARBARA and Developmental Biology and the Biomolecular Science and Engineering Program at UC Santa Barbara in July 2009. He holds a joint appointment with the Sanford-Burnham Medical CHANCELLOR HENRY T. YANG Research Institute and is the Director of The UC Santa Barbara Sanford-Burnham Center for Nanomedicine. Dr. Marth’s cordially invites you to attend the inaugural lecture training and expertise are multi-disciplinary encompassing and reception celebrating the appointment of genetics, pharmacology, biochemistry, immunology, hematology, developmental biology, infectious disease, and glycobiology. His laboratory is known for having DR. JAMEY MARTH developed Cre-loxP conditional mutagenesis, a technique used worldwide to study Professor of Molecular, Cellular, and Developmental Biology biology and disease, and for elucidating mechanisms of autoimmune disease, Type 2 diabetes, and infectious disease. His laboratory is incorporating nanotechnologies TO THE including microfluidic, and microarray platforms to expand basic biological research John Carbon Chair in Biochemistry and Molecular Biology capabilities and further identify the origins of disease.
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The American Association of Immunologists Oral History Project
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Researchers Discover Mechanistic Link Between High-Fat Diet and Type 2 Diabetes
DECEMBER 29, 2005 Researchers Discover Mechanistic Link Between High-Fat Diet and Type 2 Diabetes Howard Hughes Medical Institute researchers have discovered a molecular link between a high-fat, Western-style diet, and the onset of type 2 diabetes. In studies in mice, the scientists showed that a high-fat diet interferes with a genetic mechanism they discovered that promotes insulin production, resulting in the classic signs of type 2 diabetes. In an article published in the December 29, 2005, issue of the journal Cell, the researchers report that knocking out a single gene encoding the enzyme GnT-4a glycosyltransferase (GnT-4a ) disrupts insulin production. Importantly, the scientists showed that a high-fat diet suppresses the activity of GnT-4a and leads to type 2 diabetes due to failure of the pancreatic beta cells. "We have discovered a mechanistic explanation for beta cell failure in response to a high-fat diet and obesity, a molecular trigger which begins the chain of events leading from hyperglycemia to insulin resistance and type 2 diabetes." -- Jamey D. Marth We have discovered a mechanistic explanation for beta cell failure in response to a high-fat diet and obesity, a molecular trigger which begins the chain of events leading from hyperglycemia to insulin resistance and type 2 diabetes, said Jamey Marth, a Howard Hughes Medical Institute investigator at the University of California, San Diego (UCSD). Marth and first author Kazuaki Ohtsubo at UCSD collaborated on the studies with researchers from the Kirin Brewery Co. Ltd., and the University of Fukui, both in Japan. The discovery of the link between diet and insulin production offers new information that may aid in the development of treatments that target the early stages of type 2 diabetes.
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View a PDF Copy of the Embodi Brochure
MACULAR DEGENERATION HEART DISEASE CANCER We are in a new era of human health research where progress depends on disciplines University of California Santa Barbara working together to understand the complex mechanisms of disease and illness that impact millions of lives worldwide. UC Santa Barbara sets the global precedent for collaboration. Our biological sciences, engineering, and physical sciences join forces Engineering Medicine Biology Discovery Innovation to develop innovative basic research and technological solutions. Our researchers work in partnership with academic, industry, and medical communities around the world to confront society’s most pressing medical problems. THIS IS THE neW medicine ALZHEIMERSDIABETES DRUG DELIVERY BRAIN QUANTITATIVE BIOLOGY COLLABORATING FOR A CURE FOR BLINDNESS Among the most influential leaders in stem A stem cell is essentially a “blank” cell, capable cell research worldwide, UC Santa Barbara’s of becoming another more differentiated cell researchers are spearheading the charge in type in the body, such as a skin cell, a muscle regenerative medicine. Dennis Clegg (left), cell, or a nerve cell. They can serve as a built-in Tom Soh (middle), James Thomson (upper repair system for the human body, replenishing right), and Peter Coffey (lower right), are as other cells as long as a person is alive. Stem versatile as the pluripotent stem cells they cell research and treatments represent perhaps are studying. These award-winning faculty mankind’s greatest opportunity to fulfill the are passionate about understanding the ancient call to “heal the sick,” relieve suffering, complexities of human vision and finding and improve the quality of life for an untold cures for neurodegenerative diseases.
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Effect of Carbon Source on the Glycosylation Pathway Of
Department of Chemistry and Biomolecular Sciences Effect of carbon source on the glycosylation pathway of Trichoderma reesei RUT-C30 Chris Ashwood Bachelor of Forensic Science 10th of October, 2014 A dissertation submitted in partial fulfilment of the Master of Research degree Table of Contents Declaration ....................................................................................................................................... iii Acknowledgements .......................................................................................................................... iv Abstract ............................................................................................................................................. v Abbreviations and symbol nomenclature ........................................................................................ vi Chapter 1 – Introduction ................................................................................................................... 1 1.1 The fungus Trichoderma reesei RUT-C30: a protein production machine. ............................. 1 1.1.1 History of the strain .......................................................................................................... 1 1.1.2 Protein glycosylation in Trichoderma reesei ..................................................................... 2 1.2 Metabolomics .......................................................................................................................... 6 1.2.1 Metabolomics in cellular physiology
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Do 68 Molecules Hold the Key to Understanding Disease? 4 September 2008
Do 68 molecules hold the key to understanding disease? 4 September 2008 and eight kinds of lipids (which compose cell membranes) along with the more well-known 20 amino acids that are used to make proteins and the eight nucleosides that compose the nucleic acids, DNA and RNA. "These 68 building blocks provide the structural basis for the molecular choreography that constitutes the entire life of a cell," said Marth. "And two of the four cellular components are produced by these molecular building blocks in processes that cannot be encoded by the genes. These cellular components – the glycans and lipids – may Illustration of basic molecular building blocks. Credit: now hold the keys to uncovering the origins of UCSD School of Medicine many grievous diseases that continue to evade understanding." Currently, the vast majority of medical research Why is it that the origins of many serious diseases looks to the human genome and proteome for remain a mystery? In considering that question, a answers, but those answers remain elusive, and scientist at the University of California, San Diego perhaps for good reason. School of Medicine has come up with a unified molecular view of the indivisible unit of life, the cell, "We have now found instances where the which may provide an answer. pathogenesis of widespread and chronic diseases can be attributed to a change in the glycome, for Reviewing findings from multiple disciplines, example, in the absence of definable changes in Jamey Marth, Ph.D., UC San Diego Professor of the genome or proteome," Marth said, adding that, Cellular and Molecular Medicine and Investigator as biomedical researchers, "we need to begin to with the Howard Hughes Medical Institute, realized cultivate the integration of disciplines in a holistic that only 68 molecular building blocks are used to and rigorous way in order to perceive and most construct these four fundamental components of effectively manipulate the biological mechanisms of cells: the nucleic acids (DNA and RNA), proteins, health and disease." glycans and lipids.
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Glycomic Analysis of Biomedically Important O-glycoconjugates A thesis submitted for the Degree of Doctor of Philosophy of Imperial College London Submitted by Mohd Nazri Ismail Imperial College London Division of Molecular Biosciences Department of Life Sciences Faculty of Natural Sciences South Kensington London SW7 2AZ United Kingdom 2 Declaration I hereby declare that the work presented in this thesis has not been previously or concurrently submitted for any other degree, diploma or other qualification at any other university, and it is the result of my own independent research unless otherwise indicated. Mohd Nazri Ismail 3 Acknowledgements This PhD work would not have been possible without the support of many people. I would like to express my deepest gratitude to my supervisor, Prof. Anne Dell who was abundantly helpful and offered invaluable assistance, support and guidance. Deepest appreciation is also due to my second supervisor, Dr. Stuart Haslam, without whose knowledge and assistance this thesis would not have been successful. Special thanks also to all former and current group members, Prof. Howard Morris, Dr. Maria Panico, Dr. Berangere Tissot, Dr. Mark Sutton-Smith, Dr. Aristotelis Antonopoulos, Alana Trollope, Rebecca Harrison, Kevin Canis, Dr. Poh-Choo Pang, Dr. Paul Hitchen, Dr. Rositsa Karamanska, David Damerell, Dr. Simon Parry, Dr. Alessio Ceroni and Dr. Simon North, for sharing knowledge and invaluable assistance. Not forgetting to my friends who always been there and making my life journey in this wonderful but challenging city of London much smoother. It was an honour for me to collaborate with some of the best scientists in this field, including Prof Jamey Marth, Dr.
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UC San Diego UC San Diego Electronic Theses and Dissertations
UC San Diego UC San Diego Electronic Theses and Dissertations Title CD8⁺ T lymphocyte apoptosis is regulated by protein O- glycosylation Permalink https://escholarship.org/uc/item/2793t53h Author Van Dyken, Steven John Publication Date 2006 Peer reviewed|Thesis/dissertation eScholarship.org Powered by the California Digital Library University of California UNIVERSITY OF CALIFORNIA, SAN DIEGO CD8+ T Lymphocyte Apoptosis is Regulated by Protein O-Glycosylation A dissertation submitted in partial satisfaction of the requirement for the degree Doctor of Philosophy in Biomedical Sciences by Steven John Van Dyken Committee in charge: Professor Jamey D. Marth, Chair Professor Steven F. Dowdy Professor Ananda W. Goldrath Professor Mitchell Kronenberg Professor Ajit P. Varki 2006 Copyright Steven John Van Dyken, 2006 All rights reserved DEDICATION To my parents, My role models, John and Sandy Van Dyken, For their unconditional love and support And To my wife, Jennifer My heart and soul, For her infinite love, endurance, and devotion, I love you iv TABLE OF CONTENTS Signature Page .......................................................................................................... iii Dedication.................................................................................................................. iv Table of Contents........................................................................................................v List of Figures .........................................................................................................
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