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TRIP TO FRONTIERS 4 The Cuba Collaboration INSTITUTO DE MEDICINA TROPICAL OCTOBER 30 – NOVEMBER 03 2019 05 DAYS | 04 NIGHTS

T R I P O U T L I N E

DAY 01 WEDNESDAY OCT 30 USA - LA HABANA BIEVENIDOS | WELCOME TO CUBA

DAY 02 THURSDAY OCT 31 LA HABANA EXPLORE OLD AND CLASSIC HAVANA

DAY 03 FRIDAY NOV 01 LA HABANA EXPLORE THE COMMUNITY WORK IN HAVANA

DAY 04 SATURDAY NOV 02 LA HABANA EXPLORE THE COMMUNITY WORK IN LAS TERRAZAS

DAY 05 SUNDAY NOV 03 LA HABANA – USA ADIOS CUBA

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T R I P O U T L I N E

DAY 1 USA - LA HABANA | BIENVENIDOS A CUBA WEDNESDAY OCTOBER 30 2019

ARRIVE TO HAVANA | JOSE MARTI INTERNATIONAL AIRPORT CITY TOUR | VIA SCENIC ROUTE HOTEL CHECK IN |HOTEL COPACABANA WELCOME DINNER | HEMINGWAY YACHT CLUB

DAY 2 LA HABANA | EXPLORE COLONIAL & CLASSIC HAVANA | CULTURAL CITY TOURS THURSDAY OCTOBER 31 2019

MORNING | CUBAN PRESENTATIONS LUNCH | IPK AFTERNOON | PANORAMIC CITY TOUR | ANTIQUE CARS WALKING TOUR OF VISIT AND TOUR DINNER | CAFÉ TABERNA BENNY MORE

DAY 3 LA HABANA | EXPLORE THE COMMUNITY WORK IN HAVANA FRIDAY NOVEMBER 01 2019

MORNING | CUBAN PRESENTATIONS LUNCH | IPK AFTERNOON | VISIT COMMUNITY PROJECT | TOUR FUSTARLANDIA VISIT AND TOUR | NECROPOLIS DE LA HABANA VISIT COMMUNITY PROJECT | TOUR OPERA DE LA CALLE EVENING | FREE TIME

DAY 4 LA HABANA | EXPLORE THE COMMUNITY WORK IN LAS TERRAZAS SATURDAY NOVEMBER 02 2019

MORNING | CUBAN PRESENTATIONS LUNCH | IPK AFTERNOON | VISIT COMMUNITY PROJECT | LAS TERRAZAS DINNER | LA FONTANA

DAY 5 LA HABANA | ADIOS CUBA SATURDAY NOVEMBER 03 2019

CUBAN DEPARTURES

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D E T A I L E D T R I P O U T L I N E

DAY 1 USA - LA HABANA | BIENVENIDOS A CUBA WEDNESDAY OCTOBER 30 2019

ALL DAY TRAVEL DAY TO CUBA| Exclusive transportation depending on client’s arrival schedule

ARRIVE TO HAVANA | JOSE MARTI INTERNATIONAL AIRPORT

C CITY TOUR VIA SCENIC ROUTE An introductory driving tour of Havana ( and Old Havana) in your way to lunch in el Vedado district of Modern Havana. Travel back in time as you arrive in Cuba, sit back and enjoy a city tour via your scenic route as you enter the City of Havana. Drive along the water front The Malecon; the Metropolitan balcony that borders the coast for about 12 kilometers, from the entrance of Havana Bay (La Punta Castle) to the fortress of La Chorrera, near the mouth of the river Almendares.

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HOTEL CHECK-IN | HOTEL COPACABANA Hotel Copacabana is open to the sea, right on the Atlantic; an establishment with a nautical flavor; but located right in the middle of the town of Havana. Since 1957, the Copacabana has been part of the exclusive Miramar district in the western area of Havana, the capital of Cuba. Hotel Copacabana features a natural pool directly connected to the ocean, as well as a freshwater pool, is a hotel with a nautical flavour, offering the Atlantic right in the city. Its location on main thoroughfares such as the Quinta Avenida (Fifth Avenue) makes it very easy to reach in just a few minutes.

19:00 HRS | WELCOME DINNER | HEMINGWAY INTERNATIONAL YATCH CLUB Welcome Dinner hosted by the Ministry and IPK officials, welcome Dr. Mirta Copello & Dr. Lizette Gill del Valle / Dr Mark T. Weiser program and welcome. Return to hotel when finish.

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DAY 2 LA HABANA | EXPLORE COLONIAL & CLASSIC HAVANA | CULTURAL CITY TOURS THURSDAY OCTOBER 31 2019

07:30 HRS | DEPARTURE FROM HOTEL TO IPK | After breakfast at the Copacabana Hotel depart to IPK Institute for conference

08:00 – 09:00 HRS | CUBAN PRESENTATION Dr Mirta Copello |Salvador Allende Hospital Preclinical & Clinical Work with Restenosis Pigmentaria

09:00- 12:00 HRS | PRESENTATION - LECTURE AND HANDS ON - Frank Shallenberger | Update on medical applications of Ozone Therapies

12:00 – 13:00 HRS | CUBAN PRESENTATION Dr. Olga Sonia Leon Fernandez, PhD - Preclinical & Clinical research of Ozone & Derivative products in different diseases

13:00 – 14:00 HRS | LUNCH IPK

15:00 HRS | PANORAMIC CITY TOUR | ANTIQUE CARS Departure from your Hotel Copacabana in vintage cars for panoramic visit to external areas of Miramar and El Vedado to Plaza de la Revolucion.

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Continue this panoramic visit to the former Centro Gallego | Teatro Nacional - at the Parque Central via the famous El Prado – Paseo de Marti Boulevard. Visit the external areas of Capitolio Nacional and later engage the famous sea side avenue – El Malecon till you arrive Old Havana and visit the four main squares.

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WALKING TOUR OF OLD HAVANA Walk through the main streets and squares of the historic center of Old Havana, a UNESCO World Heritage Site. Filled with architectural jewels spanning five hundred years, La Habana Vieja enchants and visitors with one of the finest ensembles of urban edifices in the world. At a conservative estimate, Old Havana accumulates over 1000 buildings of historical significance, with myriad examples of architecture ranging from 16th-century Spanish Colonial to 17th Century Cuban to 19thCentury Neoclassical to 20th Century Eclectic Modern, including Art Noveau and Art Deco. In the morning visit LA ALAMEDA DE PAULA, LA PLAZA DE SAN FRANCISCO DE ASSISI, LA PLAZA DEL CRISTO and LA PLAZA VIEJA, in the afternoon visit LA PALZA DE ARMAS and LA , all which are of the greatest colonial architectural heritage of Havana.

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At the end visit San Jose handicraft market and time for shopping. For people wanting to leave Cuba with a one-of-a-kind souvenir, Almacenes San José is worth a visit. Located in a large two-story warehouse, this market features the work of hundreds of Cuban artists. It’s the perfect market to buy original paintings, handmade jewelry, and hammocks. It’s Havana’s only covered outdoor market, so visitors can shop in the shade. Almacenes San José is a local favorite, so it won’t feel as touristy as other markets. Just be prepared to bargain for your art and ask for a certificate if it’s original.

VISIT TO MORRO CASTLE FORTRESS Visit to Morro Castle fortress external areas to observe sunset and visit to Cristo de la Habana. The FORTALEZA DE SAN CARLOS DE LA CABAÑA, colloquially known as La Cabaña, an 18th-century fortress complex, the third-largest in the Americas, located on the elevated eastern side of the harbor entrance in Havana, Cuba. The fort rises above the 200-foot hilltop, along with Morro Castle. Up to the mid XX century it was home to one of the most notorious prisons. Today declared a World Heritage site by UNESCO, the complex is

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now part of a historical park, along with the EL MORRO fortress, and houses several museums open to the public. As you walk thru the fortress in your way to the top of the where the ceremony takes place every night, you will have the opportunity to mingle and shop from local Cuban artist that every night set up their art booths in the old cobble streets of the fort. At 9 PM every evening, a cannon is fired and the so-called "EL CAÑONAZO DE LAS 9", a custom kept from colonial times signaling the closure of the gates in the city wall takes place. Foreign travelers and locals to the city have the unique opportunity to witness a tradition that began in the eighteenth century. You will also have a unique chance to mingle with hundreds of Cubans who are drawn to the ceremony each night. The saying goes among the Cuban people that if you are a real Cuban, you must have attended the shooting of the cannon at least once in your lifetime.

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19:00 HRS DINNER | CAFÉ TABERNA BENY MORE - Departure to private restaurant from the area. After dinner enjoy the show with alive music and performance of 50’s traditional Cuban music band in Café Taberna Benny More 3 drinks included. Return to Hotel Copacabana when finish by midnight.

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DAY 3 LA HABANA | EXPLORE THE COMMUNITY WORK IN LA HABANA FRIDAY NOVEMBER 01 2019

07:30 HRS | DEPARTURE FROM HOTEL TO IPK After breakfast at the Copacabana Hotel depart to IPK Institute for conference

08:00 – 09;00 HRS | CUBAN PRESENTATION Msc Janet Cepero- INOR- Preclinical & Rlinical Research of Ozone & derivative products in cancer Dr. Judith Mendiola Martinez. IPK Preclinical Research of Ozone in malaria

09:00- 12:00 HRS | PRESENTATION & WORKSHOPS Dental presentations and workshop Tim Rainey (USA) & Fadi Sabbah (Lebanon)DDS on the many uses of both Hydrogen and Ozone Therapies

11:00 – 13:00 HRS | WORKSHOP Dr. Erick Zaremski advanced ozone techniques and hands on workshop

13:00 – 14:00 HRS | LUNCH IPK

15:00 HRS | VISIT AND TOUR FUSTERLANDIA Departure from Hotel in coco taxis, visit to Fusterlandia Community Project located in Jaimanitas neighborhood. A Cuban artist reclaimed his impoverished neighborhood as a dreamy folkart kingdom. In 1975, after moving into a modest wood house in the rundown neighborhood of Jaimanitas outside Havana, Fuster set about decorating his studio in colorful mosaic. Once he was done there, he asked his neighbors if he

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could decorate their homes and business as well. A few accepted his offer and the tile creations grew. Over the course of a decade, doctors’ offices, bus stops, fountains, benches, gateways, and more were enveloped by Fuster’s whimsical imagination. Today, his artwork coats the neighborhood in a rainbow of strange, enchanting fantasy. Jaimanitas was an economically depressed area before Fuster arrived, and now it has turned into an artist’s paradise. Tourists are bussed into the neighborhood to admire Fuster’s still-growing kingdom, which has spawned a new generation of artists inspired by the surroundings they came up in.

16:00 HRS VISIT AND TOUR NECROPOLIS DE LA HABANA The Colon Cemetery, or more fully in the Spanish language Cementerio de Cristóbal Colón, was founded in 1876 in the Vedado neighborhood of Havana, Cuba on top of . Named for Christopher Columbus, the 140 acre (57 ha) cemetery is noted for its many elaborately sculpted memorials. It is estimated that today the cemetery has more than 500 major mausoleums, many built by Victor Citarella, chapels, and family vaults. Colon Cemetery is one of the great historical cemeteries of the world, and is generally held to be the most important in in historical and architectural terms. Prior to the opening of the Colon Cemetery, Havana's dead were laid to rest in the crypts of local church catacombs and then, beginning in 1806, at Havana's newly opened Espada Cemetery.

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When locals realized there would be a need for a larger space for their community’s dead (due to an 1868 cholera outbreak), planning then began for the Colon Cemetery. It was built by the Galician architect Calixto Arellano de Loira y Cardoso, a graduate of Madrid’s Royal Academy of Arts of San Fernando, and who became Colón’s first occupant when he died before his work was completed. Yet for all its elegance and grandeur Colon Cemetery conceals as much as it displays. Empty tombs and desecrated family chapels disfigure the stately march of Cuban family memorials even in the most prominent of the avenues, and away from the central cross-streets, ruin. Many of these are the tombs of exiled families, whose problems with caring for their dead have been complicated by residence in new countries. The first impact of Colon Cemetery is a seemingly endless succession of tombs blinding white in the midday heat, few shade trees and nowhere to sit. In front of the main entrance, at the axes of the principal avenues Avenida Cristobal Colón, Obispo Espada and Obispo Fray Jacinto, stands the Central Chapel apparently modelled on Il Duomo in Florence. On every side rectangular street lead geometrically to the cemetery’s 56 hectares, designed by Loira to define the rank and social status of the dead with distinct areas, almost city suburbs: priests, soldiers, brotherhoods, the wealthy, the poor, infants, victims of epidemics, pagans and the condemned. The best preserved and grandest tombs stand on or near these central avenues and their axes.

18:30 HRS VISIT AND TOUR OPERA DE LA CALLE

FREE NIGHT

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DAY 4 LA HABANA | EXPLORE THE COMMUNITY WORK IN LAS TERRAZAS SATURDAY NOVEMBER 02 2019

07:30 HRS | DEPARTURE FROM HOTEL TO IPK After breakfast at the Copacabana Hotel depart to IPK Institute for conference

08:00 – 09:00 HRS | CUBAN PRESENTATION

Dr. Zullyt Zamora Rodriguez - CPN preclinical research of ozone in animals

Dr. Maria Teresa Soto PhD Preclinical & Clinical research on ozone and derivative products and alcoholic addiction

Dr.Oscar Ledea Lozano -CNIC Institute Research in ozone products & by products

09:00 -13:00 HRS | PRESENTATION & WORKSHOPS Ozone/PRP & Autologous Therapies Workshop Dr. Dennis Harper and Dr Carmen Mora (USA)

13:00 – 14:00 HRS | LUNCH IPK

14:00 HRS TRAVEL TO AND TOUR LAS TERRAZAS COMMUNITY PROJECT Departure from Hotel Copacabana by bus to visit Las Terrazas Community Project reserve of the biosphere declared by UNESCO as human heritage site. We are a cultural landscape of 5000 ha available to lovers of nature tourism, which is part of the Las Terrazas Community, and which is located within the Biosphere Reserve, Artemisa Province. Area rich in flora and fauna, historic sites, lakes, rivers, waterfalls and the presence of a population settlement of approximately 1000 inhabitants, protagonists of the only rural experience in sustainable development in Cuba.

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Lodging of families of peasants, workers, plastic artists, musicians, craftsmen, current hosts of those interested in knowing, interacting and sharing actions in favor of human improvement.

16:30 HRS TRAVEL TO HAVANA Return to Hotel Copacabana

19:00 HRS RECOGNITION DINNER La Fontana RESTAURANT

DAY 5 LA HABANA | ADIOS CUBA

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SUNDAY NOVEMBER 03 2019

ALL DAY TRAVEL DAY FROM CUBA| Exclusive transportation depending on client’s departure schedule

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