Antimicrobial Agents and Chemotherapy

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

VOLUME 18 0 NUMBER 1 * JULY 1980 EDITORIAL BOARD LEON H. SCEHMIrDT, Editor-in-Chief (1985) ROBERT L. HAMIL, Editor (1985) University ofAlabama in Birmingham, Eli Lilly & Company, Inc. Birmingham, Alabama Indianapolis, Indiana HERBERT L. ENNIS, Editor (1982) EDWARD W. HOOK, Editor (1981) Roche Institute ofMolecular Biology, University of Virginia, Charlottesville Nutly, New Jersey GEORGE A. JACOBY, JR., Editor (1985) JOEL G. FLAKS, Editor (1981) Massachusetts General Hospital University ofPennsylvania, Philadelphia Boston, Massachusetts

Vincent T. Andriole (1981) Milton Huppert (1980) Richard Root (1980) John P. Anhalt (1981) George Gee Jackson (1980) Jon E. Rosenblatt (1982) Donald Armstrong (1980) George A. Jacoby, Jr. (1982) Milton R. J. Salton (1981) Robert Austrian (1980) Thomas Jones (1980) Merle Sande (1982) Arthur L. Barry (1980) William J. Jusko (1980) Jay Sanford (1980) John E. Bennett (1981) Donald Kaye (1982) Arthur K. Saz (1982) Lawrence E. Bryan (1982) Jerome 0. Klein (1982) F. C. Sciavolino (1982) Robert E. Brummitt (1982) Vernon Knight (1980) Oldrich K. Sebek (1980) D. Buyske (1980) George S. Kobayashi (1982) William M. Shannon (1980) Yves Chabbert (1980) Jordan Konisky (1980) Jerome J. Schentag (1982) Royston C. Clowes (1980) Matthew E. Levison (1981) John C. Sherris (1980) C. Glenn Cobbs (1980) Friedrich C. Luft (1981) Charles Shipman, Jr. (1982) Paul S. Cohen (1980) Joan Lusk (1980) Robert W. Sidwell (1981) Naomi Datta (1981) R. Luthy (1980) Walter Siegenthaler (1980) Julian Davies (1980) Gerald L. Mandell (1980) Sigmund S. Socransky (1980) Lawrence E. Day (1980) Gerald Medoff (1980) P. Frederick Sparling (1981) R. Gordon Douglas, Jr. (1980) Barbara Minshew (1982) R. Sutherland (1982) Theodore Eickhoff (1982) S. Mitsuhashi (1980) Vera L. Sutter (1981) Arthur English (1980) Robert C. Moellering, Jr. (1982) Morton N. Swartz (1982) David S. Feingold (1981) R. B. Morin (1982) Richard B. Sykes (1982) Robert Fekety (1981) Bernard Moss (1981) Ralph Tompsett (1982) Sydney Finegold (1982) John D. Nelson (1980) Hamao Umezawa (1981) Robert J. Fitzgerald (1980) Harold C. Neu (1980) Donald Van Harken (1982) Anthony J. Glazko (1981) J. F. Niblack (1980) D. Vazquez (1980) Irving H. Goldberg (1982) T. J. Perun (1980) Michael Waring (1981) Harry Gooder (1982) Charles A. Plate (1982) John Washington 1 (1981) Jack Gwaltney (1980) Burton M. Pogell (1981) Pamela Waterworth (1982) Robert L. Hamill (1982) K. E. Price (1982) Jerry A. Weisbach (1982) Maurice W. Harmon (1981) Paul Quie (1980) B. Weisblum (1982) Michael Higgins (1980) W. H. G. Richards (1980) Peter G. Welling (1982) Ronald D. Hinsdill (1982) Mark H. Richmond (1982) Richard Wenzel (1980) Richard Hornick (1980) R. W. Rickards (1980) L. H. Huang (1982) Richard Roberts (1982)

Gisella Pollock, Acting Managing Editor Lorraine Gilbert, Production Editor 1913 I St., NW, Washington, DC 20006

EX OFFICIO Albert Balows, President (1980-1981) Frederick C. Neidhardt, President-Elect (1980-1981) J. Mehsen Joseph, Secretary Brinton M. Miller, Treasurer Antimicrobial Agents and Chemotherapy (ISSN 0066- Second class postage paid at Washington, D.C. 20006, and at 4804), an interdisciplinary publication ofthe American Society additional mailing offices. for Microbiology, 1913 I St., N.W., Washington, D.C. 20006, is Made in the United States of America. devoted to the dissemination of knowledge relating to all Copyright i 1980, American Society for Microbiology. aspects of antimicrobial agents, anticancer agents, and chemo- All Rights Reserved. therapy. Instructions to Authors are published in the January The code at the top of the first page of an article in this issue each year. Antimicrobial Agents and Chemotherapy is journal indicates the copyright owner's consent that copies of published monthly, and the twelve numbers are divided into the article may be made for personal use, or for personal use two volumes per year. The nonmember subscription price is of specific clients. This consent is given on the condition, $65 per year. The member subscription price is $16 per year. however, that the copier pay the stated per-copy fee through Single copies are $6. Correspondence relating to subscriptions, the Copyright Clearance Center, Inc., P.O. Box 765, Schenec- reprints, defective copies, availability of back issues, lost or tady, New York 12301, for copying beyond that permitted by late proofs, disposition of submitted manuscripts, and general Sections 107 and 108 of the U.S. Copyright Law. This consent editorial matters should be directed to the ASM Publications does not extend to other kinds of copying, such as copying for Office, 1913 I St., NW, Washington, DC 20006 (area 202 833- general distribution, for advertising or promotional purposes, 9680). for creating new collective works or for resale.

Ela*:~K - tETg E -ta (Who Author Index Amatnieks, Yuri E., 101 Gordts, B., 118 Oliva, Brunello, 200 Arai, Susumu, 1 Grinsted, John, 200 Arango, Maria D., 190 Grossberg, Sidney E., 20 Pesanti, Edward L., 208 Arnaud, J. P., 69 Peterson, Lance R., 210 Aronoff, George R., 212 Halstead, Scott B., 125 Petrucelli, S., 137 Harawawa, Ry6, 58 Plevani, Paolo, 50 Badaracco, Gianfranco, 50 Hatheway, Charles L., 13 Pupkoff, Robert, 206 Barry, Arthur L., 88 Hottendorf, G. H., 176 Bennett, Peter M., 200 Ralph, Edward D., 101 Blomster, Ralph N., 171 Restrepo M., Angela, 190 Bolton, L., 137 Inoue, Matsuhisa, 77 Rogers, Henry J., 63 Brogard, J. M., 69 Irie, Kenji, 37 Brook, Itzhak, 164 Izawa, Akio, 37, 41, 45 Saral, R., 158 Butzler, J. P., 118 Schoenherr, Christine K., 20 Jones, Ronald N., 88 Schurig, Randolf, 81 Calhoun, Leslie, 164 J0rgensen, Sigrid Tue, 200 Scovill, John P., 27 Cheme, John E., 210 Shono, Fumiaki, 45 Coignau, H., 118 Simon, Gary L., 167 Comber, K. R., 182 Kabat, William J., 122 Slots, J0rgen, 9 Kampf, Dieter, 81 Snydman, David R., 167 Kawahara, Kazuo, 45 Soike, Kenneth F., 142 Dick, J. D., 158 Kisaki, Yoko, 37 Sommers, Herbert M., 88 Dickson, Edward T., 27 Klayman, Daniel L., 27 Sora, Silvio, 50 Dierickx, R., 118 Kleit, Stuart A., 212 Speedie, Marilyn K., 171 Dobek, Arthur S., 27 Koff, Wayne C., 125 Sutherland, R., 182 Dobeli, H., 111 Komatsu, Toshiaki, 37, 41, 45 Suzuki, Kunio, 58 Domer, M., 69 Kopferschmitt, J., 69 Svaan, John, 206 Dowell, V. R., Jr., 13 Kurashige, S., 105 Swenson, Jana M., 13 Synge, Charlotte, 63 Eda, Yasuko, 37 Szwed, James J., 212 Elm, Joe L., Jr., 125 Lavillaureix, J., 69 Evans, Richard T., 9 Liu, Fung Y., 148 Takaoka, Masayoshi, 195 Lobbins, Phyllis M., 9 Tally, Francis P., 167 Felsenfeld, Ambhan D., 142 Taylor, Jerry L., 20 Fique, Dorothy V., 171 Marcus, Edwin L., 212 Thornsberry, Clyde, 13, 88 Fleischaker, Robert J., 130 Masuyoshi, Shinji, 1 Tramont, Edmund C., 27 Foleno, B., 137 Matsubara, Nobuyuki, 195 Forster, Dieter, 81 Matsuhashi, Michio, 195 Umeda, Isao, 45 Fuchs, Peter C., 88 McCroskey, Loretta M., 13 Means, B., 137 Vanhoof, R., 118 Meisel, Steven, 206 Thomas 88 Gavan, L., Merz, W. G., 158 Weihermiiller, Klaus, 81 Genco, Robert J., 9 Minami, Shinzaburo, 77, 195 Nafsika H., White, A. R., 182 Georgopapadakou, Mitsuhashi, S., 105 Woods, Vivienne E., 63 148 Mitsuhashi, Susumu, 1, 77, 195 Gerlach, E. Hugh, 88 Mitsuoka, Tomotari, 58 K., 105 Gerone, Peter J., 142 Miya.moto, Masaki, 1 Yasuda, Giard, Donald J., 130 Yocum, Paula, 164 Gibson, Susan, 142 Yogev, Ram, 122 Ginelli, Enrico, 50 Nakagome, Takenari, 37 Yoshitake, Akira, 41, 45 Gorbach, Sherwood L., 167 Nelson, Robert L., 212 Gordon, Leon L., 176 Nuesch, J., 111 Zimmermann, Willy, 94