Mouse anti-Human MXD1 monoclonal antibody, clone 3H20 (CABT-B10722) This product is for research use only and is not intended for diagnostic use.
PRODUCT INFORMATION
Immunogen MXD1 (NP_002348.1, 60 a.a. ~ 149 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Isotype IgG1
Source/Host Mouse
Species Reactivity Human
Clone 3H20
Conjugate Unconjugated
Applications IHC, ELISA
Sequence Similarities THNEMEKNRRAHLRLCLEKLKGLVPLGPESSRHTTLSLLTKAKLHIKKLEDCDRKAVHQIDQLQR EQRHLKRQLE KLGIERIRMDSIGST
Format Liquid
Buffer In 1x PBS, pH 7.2
Storage Store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
BACKGROUND
Introduction This gene encodes a member of the MYC/MAX/MAD network of basic helix-loop-helix leucine zipper transcription factors. The MYC/MAX/MAD transcription factors mediate cellular proliferation, differentiation and apoptosis. The encoded protein antagonizes MYC-mediated transcriptional activation of target genes by competing for the binding partner MAX and recruiting repressor complexes containing histone deacetylases. Mutations in this gene may play a role in acute leukemia, and the encoded protein is a potential tumor suppressor. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Feb 2011]
45-1 Ramsey Road, Shirley, NY 11967, USA Email: [email protected]
Tel: 1-631-624-4882 Fax: 1-631-938-8221 1 © Creative Diagnostics All Rights Reserved Keywords MXD1; MAX dimerization protein 1; MAD; MAD1; BHLHC58; max dimerization protein 1; max dimerizer 1; MAX-binding protein; antagonizer of myc transcriptional activity;
GENE INFORMATION
Entrez Gene ID 4084
UniProt ID Q05195
Pathway Regulation of Telomerase, organism-specific biosystem; Signaling events mediated by HDAC Class I, organism-specific biosystem;
Function DNA binding; sequence-specific DNA binding transcription factor activity; transcription cofactor activity; transcription corepressor activity;
45-1 Ramsey Road, Shirley, NY 11967, USA Email: [email protected]
Tel: 1-631-624-4882 Fax: 1-631-938-8221 2 © Creative Diagnostics All Rights Reserved