Anti-RNASE1 (GW10801F)

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Anti-RNASE1 antibody produced in chicken, affinity isolated antibody Catalog Number GW10801F Formerly listed as GenWay Catalog Number 15-288- 10801F, Ribonuclease pancreatic Antibody. Storage Temperature –20 °C EC 3.1.27.5 Precautions and Disclaimer Synonyms: Pancreatic ribonuclease; RNase 1; This product is for R&D use only, not for drug, RNase A; RNase UpI-1; RIB-1; HP-RNase household, or other uses. Due to the sodium azide content a material safety data sheet (MSDS) for this Product Description product has been sent to the attention of the safety Endonuclease that catalyzes the cleavage of RNA on officer of your institution. Please consult the Material the 3¢ side of pyrimidine nucleotides. Acts on single Safety Data Sheet for information regarding hazards stranded and double stranded RNA. and safe handling practices. NCBI Accession number: NP_002924.1 Storage/Stability Swiss Prot Accession number: P07998 For continuous use, store at 2–8 °C for up to one week. For extended storage, store in –20 °C freezer in Gene Information: Human .. RNASE1 (6035) working aliquots. Repeated freezing and thawing, or storage in “frostfree” freezers, is not recommended. If Immunogen: Recombinant protein Pancreatic slight turbidity occurs upon prolonged storage, clarify ribonuclease the solution by centrifugation before use. Working dilution samples should be discarded if not used within Immunogen Sequence: Gi # 4506547, sequence 1–156 12 hours. The product is a clear, colorless solution in phosphate TD,LPG,MAM 04/09-1 buffered saline, pH 7.2, containing 0.02% sodium azide. Species Reactivity: Human Tested Applications: WB Recommended Dilutions: Recommended starting dilution for Western blot analysis is 1:500 for tissue or cell staining 1:200. Note: Optimal concentrations and conditions for each application should be determined by the user. Sigma brand products are sold through Sigma-Aldrich, Inc. Sigma-Aldrich, Inc. warrants that its products conform to the information contained in this and other Sigma-Aldrich publications. Purchaser must determine the suitability of the product(s) for their particular use. Additional terms and conditions may apply. Please see reverse side of the invoice or packing slip..

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A Computational Approach for Defining a Signature of Β-Cell Golgi Stress in Diabetes Mellitus
Page 1 of 781 Diabetes A Computational Approach for Defining a Signature of β-Cell Golgi Stress in Diabetes Mellitus Robert N. Bone1,6,7, Olufunmilola Oyebamiji2, Sayali Talware2, Sharmila Selvaraj2, Preethi Krishnan3,6, Farooq Syed1,6,7, Huanmei Wu2, Carmella Evans-Molina 1,3,4,5,6,7,8* Departments of 1Pediatrics, 3Medicine, 4Anatomy, Cell Biology & Physiology, 5Biochemistry & Molecular Biology, the 6Center for Diabetes & Metabolic Diseases, and the 7Herman B. Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, IN 46202; 2Department of BioHealth Informatics, Indiana University-Purdue University Indianapolis, Indianapolis, IN, 46202; 8Roudebush VA Medical Center, Indianapolis, IN 46202. *Corresponding Author(s): Carmella Evans-Molina, MD, PhD ([email protected]) Indiana University School of Medicine, 635 Barnhill Drive, MS 2031A, Indianapolis, IN 46202, Telephone: (317) 274-4145, Fax (317) 274-4107 Running Title: Golgi Stress Response in Diabetes Word Count: 4358 Number of Figures: 6 Keywords: Golgi apparatus stress, Islets, β cell, Type 1 diabetes, Type 2 diabetes 1 Diabetes Publish Ahead of Print, published online August 20, 2020 Diabetes Page 2 of 781 ABSTRACT The Golgi apparatus (GA) is an important site of insulin processing and granule maturation, but whether GA organelle dysfunction and GA stress are present in the diabetic β-cell has not been tested. We utilized an informatics-based approach to develop a transcriptional signature of β-cell GA stress using existing RNA sequencing and microarray datasets generated using human islets from donors with diabetes and islets where type 1(T1D) and type 2 diabetes (T2D) had been modeled ex vivo. To narrow our results to GA-specific genes, we applied a filter set of 1,030 genes accepted as GA associated.
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(12) Patent Application Publication (10) Pub. No.: US 2003/0082511 A1 Brown Et Al
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Viewed and Published Immediately Upon Acceptance 44
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