TDM 200 Kit System

TDM Platform

Therapeutic Monitoring (TDM) by LC-MS/MS The RECIPE TDM 200 Kit System

100 μl Precipitant (contains IS*)

50 μl Sample

mix, centrifuge

Inject supernatant e ste

The TDM 200 Kit System offers you the possibility to determine more than 155 different analytical parameters with one Kit System (sample preparation, mobile phases and analytical column).

155 analytical parameters in 7 Add-on Sets

TDM Platform

* Internal Standards available for most analytes. The RECIPE TDMi Kit Solution

The TDM 200 Kit System is also available as TDMi Kit Solution with direct injection of matrix.

Direct Injection Technology Internal Standard is added to native serum or plasma sample, calibrator or control automatically by just one simple pipetting step of the autosampler followed by direct injection of the individual samples into the chromato- graphic system. Subsequently, the analytes are separated and determined by on-line analysis.

Simplify your lab-routine

By direct injection of matrix Retention times < 7 min. Small sample volume needed < 20 µl ADP 37 Antidepressants Order no. MS9400

Agomelatine Guanfacine Ritalinic Acid Clomethiazole threo-Dihydro-Bupropion Mianserine Desmethylfluoxetine Desmethylmianserine Desmethylmirtazapine Desmethylsertraline O-Desmethyltramadol O-Desmethylvenlafaxine erythro-Dihydro-Bupropion

AED 26 Antiepileptic Order no. MS9200

10-OH-Carbamazepine Levetiracetam Retigabine Carbamazepine N-Desmethylmethsuximide Rufinamide Carbamazepine-diol Oxcarbazepine Stiripentol Carbamazepine-epoxide PEMA Sulthiame Ethosuximide Perampanel Tiagabine Felbamate Phenobarbital Topiramate Gabapentine Phenytoin Valproic Acid Lacosamide Pregabaline Zonisamide Lamotrigine Primidone

AMC 11 Antimycotics Order no. MS9600 5-Fluorocytosine Isavuconazole OH-Itraconazole Amphotericin B Itraconazole Posaconazole Anidulafungin Ketoconazole Voriconazole Fluconazole Micafungin 36 Benzodiazepines Order no. MS9500 BZP

3-Hydroxybromazepam Demoxepam Nordiazepam 7-Aminoclonazepam Desalkylflurazepam Oxazepam 7-Aminoflunitrazepam Desmethylflunitrazepam Prazepam 7-Aminonitrazepam Diazepam Temazepam α-Hydroxyalprazolam Estazolam Tetrazepam α-Hydroxymidazolam Flunitrazepam Trazodone α-Hydroxytriazolam Flurazepam Triazolam Alprazolam Lorazepam Zaleplon Bromazepam Lormetazepam Zolpidem Brotizolam Medazepam Zopiclone Chlordiazepoxide Midazolam Clobazam Nitrazepam Clonazepam Norclobazam

2 Mycophenolic Acid Order no. MS99100 MPA

Mycophenolic acid Mycophenolic acid glucuronide

28 Neuroleptics Order no. MS9300 NLP

Amisulpride Melperone Sertindole Norclozapine Sulpiride Chlorpromazine Norquetiapine Thioridazine Chlorprothixene Clozapine Paliperidone (9-OH-) Dehydro-Aripiprazole Perazine Zuclopenthixol Desmethylolanzapine Pipamperone Promethazine Fluphenazine Prothipendyl Haloperidol Levomepromazine Risperidone

15 Order no. MS9100 TCA

Amitriptyline Normaprotiline Nortrimipramine Clozapine Norclozapine ADP TDM Antidepressants

2.2e6 Ritalinic acid 0.726 Reboxetin 1.83 O-Desmethyltramadol 0.854 Citalopram 1.91 2.0e6 Tranylcypromin 0.95 Opipramol 1.95 O-Desmethylvenlafaxin 0.984 Mirtazapin 1.96 1.8e6 Moclobemid 1.09 Desmethylmianserin 1.98 Guanfacin 1.19 Bupropion 1.99 1.6e6 Tramadol 1.22 Paroxetin 2.13 Hydroxybupropion 1.30 Atomoxetin 2.16 1.4e6 Clomethiazol 1.31 Fluvoxamin 2.25 y (cps) 1.2e6 Methylphenidat 1.34 Duloxetin 2.33 Tianeptin 1.34 Desmethyl uoxetin 2.33 ensi t t

n Milnacipran 1.36 Dosulepin 2.55 I 1.0e6 Desmethylmirtazapin 1.41 Fluoxetin 2.62 8.0e5 Agomelatin 1.56 Desmethylsertralin 2.71 Venlafaxin 1.56 2.71 6.0e5 Dihydro-Bupropion 1.59 Nefazodon 2.81 Desmethylcitalopram 1.73 Sertralin 3.05 4.0e5 Trazodon 1.74 Vortioxetin 3.41

2.0e5

0.0 0.6 0.8 1.0 1.2 1.4 1.6 1.8 2.0 2.2 2.4 2.6 2.8 3.0 3.2 3.4 3.6

Retention time (min)

ADP TDM i Antidepressants

Direct Injection TDM Antiepileptic Drugs AED

TDM i Antiepileptic Drugs AED

Direct Injection AMC TDM Antimycotics

AMC TDM i Antimycotics

Direct Injection TDM Benzodiazepines BZP

TDM i Benzodiazepines BZP

Direct Injection

TDM Mycophenolic Acid MPA NLP TDM Neuroleptics

NLP TDM i Neuroleptics

Direct Injection TDM Tricyclic Antidepressants TCA

TDM i Tricyclic Antidepressants TCA

Direct Injection Your choice in HPLC & LC-MS/MS diagnostics

Certified and quality approved CE-IVD methods

Unique RECIPE TDM 200 Kit System

Preferred partner in more than 80 countries

RECIPE Chemicals + Instruments GmbH Dessauerstraße 3 80992 München Tel. +49 89 54 70 81 - 0 TDM kit system_b_eV2 Fax. +49 89 54 70 81 - 11 [email protected] www.recipe.de