Statistical Hypothesis Tests
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Hypothesis Testing and Likelihood Ratio Tests
Hypottthesiiis tttestttiiing and llliiikellliiihood ratttiiio tttesttts Y We will adopt the following model for observed data. The distribution of Y = (Y1, ..., Yn) is parameter considered known except for some paramett er ç, which may be a vector ç = (ç1, ..., çk); ç“Ç, the paramettter space. The parameter space will usually be an open set. If Y is a continuous random variable, its probabiiillliiittty densiiittty functttiiion (pdf) will de denoted f(yy;ç) . If Y is y probability mass function y Y y discrete then f(yy;ç) represents the probabii ll ii tt y mass functt ii on (pmf); f(yy;ç) = Pç(YY=yy). A stttatttiiistttiiicalll hypottthesiiis is a statement about the value of ç. We are interested in testing the null hypothesis H0: ç“Ç0 versus the alternative hypothesis H1: ç“Ç1. Where Ç0 and Ç1 ¶ Ç. hypothesis test Naturally Ç0 § Ç1 = ∅, but we need not have Ç0 ∞ Ç1 = Ç. A hypott hesii s tt estt is a procedure critical region for deciding between H0 and H1 based on the sample data. It is equivalent to a crii tt ii call regii on: a critical region is a set C ¶ Rn y such that if y = (y1, ..., yn) “ C, H0 is rejected. Typically C is expressed in terms of the value of some tttesttt stttatttiiistttiiic, a function of the sample data. For µ example, we might have C = {(y , ..., y ): y – 0 ≥ 3.324}. The number 3.324 here is called a 1 n s/ n µ criiitttiiicalll valllue of the test statistic Y – 0 . S/ n If y“C but ç“Ç 0, we have committed a Type I error. -
Data Collection: Randomized Experiments
9/2/15 STAT 250 Dr. Kari Lock Morgan Knee Surgery for Arthritis Researchers conducted a study on the effectiveness of a knee surgery to cure arthritis. Collecting Data: It was randomly determined whether people got Randomized Experiments the knee surgery. Everyone who underwent the surgery reported feeling less pain. SECTION 1.3 Is this evidence that the surgery causes a • Control/comparison group decrease in pain? • Clinical trials • Placebo Effect (a) Yes • Blinding • Crossover studies / Matched pairs (b) No Statistics: Unlocking the Power of Data Lock5 Statistics: Unlocking the Power of Data Lock5 Control Group Clinical Trials Clinical trials are randomized experiments When determining whether a treatment is dealing with medicine or medical interventions, effective, it is important to have a comparison conducted on human subjects group, known as the control group Clinical trials require additional aspects, beyond just randomization to treatment groups: All randomized experiments need a control or ¡ Placebo comparison group (could be two different ¡ Double-blind treatments) Statistics: Unlocking the Power of Data Lock5 Statistics: Unlocking the Power of Data Lock5 Placebo Effect Study on Placebos Often, people will experience the effect they think they should be experiencing, even if they aren’t actually Blue pills are better than yellow pills receiving the treatment. This is known as the placebo effect. Red pills are better than blue pills Example: Eurotrip 2 pills are better than 1 pill One study estimated that 75% of the -
Chapter 4: Fisher's Exact Test in Completely Randomized Experiments
1 Chapter 4: Fisher’s Exact Test in Completely Randomized Experiments Fisher (1925, 1926) was concerned with testing hypotheses regarding the effect of treat- ments. Specifically, he focused on testing sharp null hypotheses, that is, null hypotheses under which all potential outcomes are known exactly. Under such null hypotheses all un- known quantities in Table 4 in Chapter 1 are known–there are no missing data anymore. As we shall see, this implies that we can figure out the distribution of any statistic generated by the randomization. Fisher’s great insight concerns the value of the physical randomization of the treatments for inference. Fisher’s classic example is that of the tea-drinking lady: “A lady declares that by tasting a cup of tea made with milk she can discriminate whether the milk or the tea infusion was first added to the cup. ... Our experi- ment consists in mixing eight cups of tea, four in one way and four in the other, and presenting them to the subject in random order. ... Her task is to divide the cups into two sets of 4, agreeing, if possible, with the treatments received. ... The element in the experimental procedure which contains the essential safeguard is that the two modifications of the test beverage are to be prepared “in random order.” This is in fact the only point in the experimental procedure in which the laws of chance, which are to be in exclusive control of our frequency distribution, have been explicitly introduced. ... it may be said that the simple precaution of randomisation will suffice to guarantee the validity of the test of significance, by which the result of the experiment is to be judged.” The approach is clear: an experiment is designed to evaluate the lady’s claim to be able to discriminate wether the milk or tea was first poured into the cup. -
Pearson-Fisher Chi-Square Statistic Revisited
Information 2011 , 2, 528-545; doi:10.3390/info2030528 OPEN ACCESS information ISSN 2078-2489 www.mdpi.com/journal/information Communication Pearson-Fisher Chi-Square Statistic Revisited Sorana D. Bolboac ă 1, Lorentz Jäntschi 2,*, Adriana F. Sestra ş 2,3 , Radu E. Sestra ş 2 and Doru C. Pamfil 2 1 “Iuliu Ha ţieganu” University of Medicine and Pharmacy Cluj-Napoca, 6 Louis Pasteur, Cluj-Napoca 400349, Romania; E-Mail: [email protected] 2 University of Agricultural Sciences and Veterinary Medicine Cluj-Napoca, 3-5 M ănăş tur, Cluj-Napoca 400372, Romania; E-Mails: [email protected] (A.F.S.); [email protected] (R.E.S.); [email protected] (D.C.P.) 3 Fruit Research Station, 3-5 Horticultorilor, Cluj-Napoca 400454, Romania * Author to whom correspondence should be addressed; E-Mail: [email protected]; Tel: +4-0264-401-775; Fax: +4-0264-401-768. Received: 22 July 2011; in revised form: 20 August 2011 / Accepted: 8 September 2011 / Published: 15 September 2011 Abstract: The Chi-Square test (χ2 test) is a family of tests based on a series of assumptions and is frequently used in the statistical analysis of experimental data. The aim of our paper was to present solutions to common problems when applying the Chi-square tests for testing goodness-of-fit, homogeneity and independence. The main characteristics of these three tests are presented along with various problems related to their application. The main problems identified in the application of the goodness-of-fit test were as follows: defining the frequency classes, calculating the X2 statistic, and applying the χ2 test. -
This Is Dr. Chumney. the Focus of This Lecture Is Hypothesis Testing –Both What It Is, How Hypothesis Tests Are Used, and How to Conduct Hypothesis Tests
TRANSCRIPT: This is Dr. Chumney. The focus of this lecture is hypothesis testing –both what it is, how hypothesis tests are used, and how to conduct hypothesis tests. 1 TRANSCRIPT: In this lecture, we will talk about both theoretical and applied concepts related to hypothesis testing. 2 TRANSCRIPT: Let’s being the lecture with a summary of the logic process that underlies hypothesis testing. 3 TRANSCRIPT: It is often impossible or otherwise not feasible to collect data on every individual within a population. Therefore, researchers rely on samples to help answer questions about populations. Hypothesis testing is a statistical procedure that allows researchers to use sample data to draw inferences about the population of interest. Hypothesis testing is one of the most commonly used inferential procedures. Hypothesis testing will combine many of the concepts we have already covered, including z‐scores, probability, and the distribution of sample means. To conduct a hypothesis test, we first state a hypothesis about a population, predict the characteristics of a sample of that population (that is, we predict that a sample will be representative of the population), obtain a sample, then collect data from that sample and analyze the data to see if it is consistent with our hypotheses. 4 TRANSCRIPT: The process of hypothesis testing begins by stating a hypothesis about the unknown population. Actually we state two opposing hypotheses. The first hypothesis we state –the most important one –is the null hypothesis. The null hypothesis states that the treatment has no effect. In general the null hypothesis states that there is no change, no difference, no effect, and otherwise no relationship between the independent and dependent variables. -
The Scientific Method: Hypothesis Testing and Experimental Design
Appendix I The Scientific Method The study of science is different from other disciplines in many ways. Perhaps the most important aspect of “hard” science is its adherence to the principle of the scientific method: the posing of questions and the use of rigorous methods to answer those questions. I. Our Friend, the Null Hypothesis As a science major, you are probably no stranger to curiosity. It is the beginning of all scientific discovery. As you walk through the campus arboretum, you might wonder, “Why are trees green?” As you observe your peers in social groups at the cafeteria, you might ask yourself, “What subtle kinds of body language are those people using to communicate?” As you read an article about a new drug which promises to be an effective treatment for male pattern baldness, you think, “But how do they know it will work?” Asking such questions is the first step towards hypothesis formation. A scientific investigator does not begin the study of a biological phenomenon in a vacuum. If an investigator observes something interesting, s/he first asks a question about it, and then uses inductive reasoning (from the specific to the general) to generate an hypothesis based upon a logical set of expectations. To test the hypothesis, the investigator systematically collects data, either with field observations or a series of carefully designed experiments. By analyzing the data, the investigator uses deductive reasoning (from the general to the specific) to state a second hypothesis (it may be the same as or different from the original) about the observations. -
Hypothesis Testing – Examples and Case Studies
Hypothesis Testing – Chapter 23 Examples and Case Studies Copyright ©2005 Brooks/Cole, a division of Thomson Learning, Inc. 23.1 How Hypothesis Tests Are Reported in the News 1. Determine the null hypothesis and the alternative hypothesis. 2. Collect and summarize the data into a test statistic. 3. Use the test statistic to determine the p-value. 4. The result is statistically significant if the p-value is less than or equal to the level of significance. Often media only presents results of step 4. Copyright ©2005 Brooks/Cole, a division of Thomson Learning, Inc. 2 23.2 Testing Hypotheses About Proportions and Means If the null and alternative hypotheses are expressed in terms of a population proportion, mean, or difference between two means and if the sample sizes are large … … the test statistic is simply the corresponding standardized score computed assuming the null hypothesis is true; and the p-value is found from a table of percentiles for standardized scores. Copyright ©2005 Brooks/Cole, a division of Thomson Learning, Inc. 3 Example 2: Weight Loss for Diet vs Exercise Did dieters lose more fat than the exercisers? Diet Only: sample mean = 5.9 kg sample standard deviation = 4.1 kg sample size = n = 42 standard error = SEM1 = 4.1/ √42 = 0.633 Exercise Only: sample mean = 4.1 kg sample standard deviation = 3.7 kg sample size = n = 47 standard error = SEM2 = 3.7/ √47 = 0.540 measure of variability = [(0.633)2 + (0.540)2] = 0.83 Copyright ©2005 Brooks/Cole, a division of Thomson Learning, Inc. 4 Example 2: Weight Loss for Diet vs Exercise Step 1. -
The Theory of the Design of Experiments
The Theory of the Design of Experiments D.R. COX Honorary Fellow Nuffield College Oxford, UK AND N. REID Professor of Statistics University of Toronto, Canada CHAPMAN & HALL/CRC Boca Raton London New York Washington, D.C. C195X/disclaimer Page 1 Friday, April 28, 2000 10:59 AM Library of Congress Cataloging-in-Publication Data Cox, D. R. (David Roxbee) The theory of the design of experiments / D. R. Cox, N. Reid. p. cm. — (Monographs on statistics and applied probability ; 86) Includes bibliographical references and index. ISBN 1-58488-195-X (alk. paper) 1. Experimental design. I. Reid, N. II.Title. III. Series. QA279 .C73 2000 001.4 '34 —dc21 00-029529 CIP This book contains information obtained from authentic and highly regarded sources. Reprinted material is quoted with permission, and sources are indicated. A wide variety of references are listed. Reasonable efforts have been made to publish reliable data and information, but the author and the publisher cannot assume responsibility for the validity of all materials or for the consequences of their use. Neither this book nor any part may be reproduced or transmitted in any form or by any means, electronic or mechanical, including photocopying, microfilming, and recording, or by any information storage or retrieval system, without prior permission in writing from the publisher. The consent of CRC Press LLC does not extend to copying for general distribution, for promotion, for creating new works, or for resale. Specific permission must be obtained in writing from CRC Press LLC for such copying. Direct all inquiries to CRC Press LLC, 2000 N.W. -
Tests of Hypotheses Using Statistics
Tests of Hypotheses Using Statistics Adam Massey¤and Steven J. Millery Mathematics Department Brown University Providence, RI 02912 Abstract We present the various methods of hypothesis testing that one typically encounters in a mathematical statistics course. The focus will be on conditions for using each test, the hypothesis tested by each test, and the appropriate (and inappropriate) ways of using each test. We conclude by summarizing the di®erent tests (what conditions must be met to use them, what the test statistic is, and what the critical region is). Contents 1 Types of Hypotheses and Test Statistics 2 1.1 Introduction . 2 1.2 Types of Hypotheses . 3 1.3 Types of Statistics . 3 2 z-Tests and t-Tests 5 2.1 Testing Means I: Large Sample Size or Known Variance . 5 2.2 Testing Means II: Small Sample Size and Unknown Variance . 9 3 Testing the Variance 12 4 Testing Proportions 13 4.1 Testing Proportions I: One Proportion . 13 4.2 Testing Proportions II: K Proportions . 15 4.3 Testing r £ c Contingency Tables . 17 4.4 Incomplete r £ c Contingency Tables Tables . 18 5 Normal Regression Analysis 19 6 Non-parametric Tests 21 6.1 Tests of Signs . 21 6.2 Tests of Ranked Signs . 22 6.3 Tests Based on Runs . 23 ¤E-mail: [email protected] yE-mail: [email protected] 1 7 Summary 26 7.1 z-tests . 26 7.2 t-tests . 27 7.3 Tests comparing means . 27 7.4 Variance Test . 28 7.5 Proportions . 28 7.6 Contingency Tables . -
Designing Experiments
Designing experiments Outline for today • What is an experimental study • Why do experiments • Clinical trials • How to minimize bias in experiments • How to minimize effects of sampling error in experiments • Experiments with more than one factor • What if you can’t do experiments • Planning your sample size to maximize precision and power What is an experimental study • In an experimental study the researcher assigns treatments to units or subjects so that differences in response can be compared. o Clinical trials, reciprocal transplant experiments, factorial experiments on competition and predation, etc. are examples of experimental studies. • In an observational study, nature does the assigning of treatments to subjects. The researcher has no influence over which subjects receive which treatment. Common garden “experiments”, QTL “experiments”, etc, are examples of observational studies (no matter how complex the apparatus needed to measure response). What is an experimental study • In an experimental study, there must be at least two treatments • The experimenter (rather than nature) must assign treatments to units or subjects. • The crucial advantage of experiments derives from the random assignment of treatments to units. • Random assignment, or randomization, minimizes the influence of confounding variables, allowing the experimenter to isolate the effects of the treatment variable. Why do experiments • By itself an observational study cannot distinguish between two reasons behind an association between an explanatory variable and a response variable. • For example, survival of climbers to Mount Everest is higher for individuals taking supplemental oxygen than those not taking supplemental oxygen. • One possibility is that supplemental oxygen (explanatory variable) really does cause higher survival (response variable). -
Understanding Statistical Hypothesis Testing: the Logic of Statistical Inference
Review Understanding Statistical Hypothesis Testing: The Logic of Statistical Inference Frank Emmert-Streib 1,2,* and Matthias Dehmer 3,4,5 1 Predictive Society and Data Analytics Lab, Faculty of Information Technology and Communication Sciences, Tampere University, 33100 Tampere, Finland 2 Institute of Biosciences and Medical Technology, Tampere University, 33520 Tampere, Finland 3 Institute for Intelligent Production, Faculty for Management, University of Applied Sciences Upper Austria, Steyr Campus, 4040 Steyr, Austria 4 Department of Mechatronics and Biomedical Computer Science, University for Health Sciences, Medical Informatics and Technology (UMIT), 6060 Hall, Tyrol, Austria 5 College of Computer and Control Engineering, Nankai University, Tianjin 300000, China * Correspondence: [email protected]; Tel.: +358-50-301-5353 Received: 27 July 2019; Accepted: 9 August 2019; Published: 12 August 2019 Abstract: Statistical hypothesis testing is among the most misunderstood quantitative analysis methods from data science. Despite its seeming simplicity, it has complex interdependencies between its procedural components. In this paper, we discuss the underlying logic behind statistical hypothesis testing, the formal meaning of its components and their connections. Our presentation is applicable to all statistical hypothesis tests as generic backbone and, hence, useful across all application domains in data science and artificial intelligence. Keywords: hypothesis testing; machine learning; statistics; data science; statistical inference 1. Introduction We are living in an era that is characterized by the availability of big data. In order to emphasize the importance of this, data have been called the ‘oil of the 21st Century’ [1]. However, for dealing with the challenges posed by such data, advanced analysis methods are needed. -
Randomized Experimentsexperiments Randomized Trials
Impact Evaluation RandomizedRandomized ExperimentsExperiments Randomized Trials How do researchers learn about counterfactual states of the world in practice? In many fields, and especially in medical research, evidence about counterfactuals is generated by randomized trials. In principle, randomized trials ensure that outcomes in the control group really do capture the counterfactual for a treatment group. 2 Randomization To answer causal questions, statisticians recommend a formal two-stage statistical model. In the first stage, a random sample of participants is selected from a defined population. In the second stage, this sample of participants is randomly assigned to treatment and comparison (control) conditions. 3 Population Randomization Sample Randomization Treatment Group Control Group 4 External & Internal Validity The purpose of the first-stage is to ensure that the results in the sample will represent the results in the population within a defined level of sampling error (external validity). The purpose of the second-stage is to ensure that the observed effect on the dependent variable is due to some aspect of the treatment rather than other confounding factors (internal validity). 5 Population Non-target group Target group Randomization Treatment group Comparison group 6 Two-Stage Randomized Trials In large samples, two-stage randomized trials ensure that: [Y1 | D =1]= [Y1 | D = 0] and [Y0 | D =1]= [Y0 | D = 0] • Thus, the estimator ˆ ˆ ˆ δ = [Y1 | D =1]-[Y0 | D = 0] • Consistently estimates ATE 7 One-Stage Randomized Trials Instead, if randomization takes place on a selected subpopulation –e.g., list of volunteers-, it only ensures: [Y0 | D =1] = [Y0 | D = 0] • And hence, the estimator ˆ ˆ ˆ δ = [Y1 | D =1]-[Y0 | D = 0] • Only estimates TOT Consistently 8 Randomized Trials Furthermore, even in idealized randomized designs, 1.