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Alopecia in Dogs Dr Amir Davoodi, DVM

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Alopecia in Dogs Dr Amir Davoodi, DVM Page 1 of 4 Quality Veterinary Diagnostics BattLab from disease to optimal health Quality Veterinary Diagnostics from Disease to Optimal Health Issue 3/2021 Alopecia in dogs Dr Amir Davoodi, DVM. LABOKLIN - Department dermatology and allergy Alopecia or pathological hair loss is a frequent reason for consultation with dermatological patients, a variety of skin diseases in dogs can cause impairment of hair growth. Shedding is a physiological process and occurs twice a year in most dogs, but there is also a breed-specific rhythm. The anagen phase (growth phase) lasts a very long time in the poodle, for example, and is shorter in other breeds such as sheepdogs, retrievers and boxers. Reduced or arrest of the anagen phase or increased hair loss in the resting phase/telogen phase of the hair cycle can lead to alopecia in dogs. Alopecia can be caused by many processes or diseases such as endocrinopathies (hypothyroi- dism, hyperadrenocorticism, hyperestrogenism, Sertoli cell tumour), drugs (chemotherapy, drug reactions), parasites (demodicosis), infections (pyoderma, dermatophytes), immune-mediated diseases (pemphigus foliaceus, sebaceous adenitis), congenital disorders (follicular dysplasia), trauma, telogen or anagen effluvium and alopecia X. Picture Dr Maria Christian A detailed history is required to make a differential diagnosis, e.g. sudden alopecia after chemothe- multifocal. It may be a consequence of infections or rapy suggests anagen effluvium. When a dog conditions affecting the hair follicle structures (e.g. shows alopecia and another member of the family immune-mediated diseases, sebaceous adenitis). also has skin lesions, dermatophytosis diagnosis Inflammatory alopecia is not symmetrical and can should be considered. The presence of pruritus is a be primary, caused by infections of the hair folli- critical anamnestic question in choosing the correct cles as a result of conditions such as demodicosis, diagnostic algorithm. In general, one of the main dermatophytosis, pyoderma or can be secondary problems is knowing which came first, alopecia or alopecia, e.g. due to scratching in allergic diseases. itching? Also, consider the following aspects during The diagnosis can’t be based only on clinical dermatological research: examination. Diagnostic tests such as cytology, 1. The symmetry of the lesions (symmetric deep skin scraping, scotch tape, trichography, alopecia / non-symmetric alopecia) dermatophyte culture, Wood’s lamp, PCR and 2. The inflammatory properties of the lesions biopsy could be needed according to the (inflammatory alopecia / non-inflammatory diagnostic algorithm (Fig. 1). alopecia) Demodicosis Inflammatory alopecia The abnormal multiplication of Demodex mites Inflammatory alopecia is the most common cause (Demodex canis is most commonly found however of alopecia in dogs. Alopecia can be focal or Demodex cornei and Demodex injai could also be Batt Laboratories Ltd, University of Warwick Science Park, The Venture Centre, Sir William Lyons Road, Coventry CV4 7EZ Tel: 0247 632 3275. Fax: 0871 750 5323. Email: [email protected]. Page 2 of 4 present) in hair follicles or, rarely, in sebum glands Dermatophytosis causes demodicosis in dogs. According to the number of lesions, demodicosis is classified as Dermatophytes, Microsporum canis, Nannizzia localised (mild) < 4 lesions; and in generalised gypsea (formerly Microsporum gypseum) and demodicosis (moderate to severe form) when > 4 Trichophyton mentagrophytes (in dogs in rural lesions are found. Immunocompromised patients areas) cause dermatophytosis in dogs. Dermato- or young dogs (less than one-year-old) are phytosis occurs mainly in immunocompromised or predisposed to demodicosis. The classic clinical young animals, especially when cats (asymptoma- picture is a focal or multifocal to generalised tic carriers) live in the same household. Yorkshire inflammatory alopecia. Comedones, follicular cast terriers appear to be predisposed to Microsporum and hyperpigmentation are other common lesions. canis and Jack Russel Terrier to Trichophyton Lesions are usually distributed on the face, neck, mentagrophytes. The classic lesions in dogs are front paws, rump and trunk. Pruritus is not a focal to generalised non-symmetrical inflammatory primary sign, but it can occur later due to alopecia, follicular cast, desquamation, folliculitis, secondary infection. furunculosis, onychomycosis and kerion (multiple or Diagnosis of demodicosis requires deep skin solitary nodular lesions) on the face and extremities scraping, scotch tape, trichography, PCR and/or a which often occur without itching. Fungal culture biopsy. The localised form is self-limiting in most and dermatophyte PCR, trichoscopy, Wood‘s lamp patients, but generalised demodicosis can develop. and sometimes a cytological examination are useful Secondary infection must be ruled out by cytology. for diagnosing dermatophytosis. A zoonotic poten- The isoxazolines (fluralaner, sarolaner, lotilaner and tial, especially for children and immunosuppressed afoxolaner) are very effective preparations against people, makes therapy necessary. The most demodicosis. Therapy should be administered until effective topical and systemic antifungal drugs two negative skin scrapings are present one against dermatophytes are imidazoles (enliconazole, month apart. itraconazole, ketoconazole, miconazole, clotrima- zole). Topical and systemic therapies are necessary until complete resolution of the lesions is achieved and there are two negative fungal culture results four weeks apart. Figure 1: DiagnosticFig algorithm 1.- Diagnosticfor inflammatory alopecia algorithm for inflammatory alopecia Clinical history, clinical and dermatological examination Focal and multifocal alopecia • Skin scraping, trichography scotch tape and PCR for the detection of demodicosis Positive: therapy until there have • Fungal culture, trichography, Wood’s lamp and been two negative test results PCR for the detection of dermatophytosis Negative Cytology Intracellular cocci and degenerate - Non-degenerate neutrophils and acantholytic cells: neutrophils: pyoderma suspected on pemphigus folicaeous - Reference to tumour cells Therapy up to a week after healing Biopsy for definitive diagnosis Batt Laboratories Ltd, University of Warwick Science Park, The Venture Centre, Sir William Lyons Road, Coventry CV4 7EZ Tel: 0247 632 3275. Fax: 0871 750 5323. Email: [email protected]. Page 3 of 4 Pyoderma Non-inflammatory alopecia Bacterial infection of the skin rarely occurs as a The causes of non-inflammatory alopecia primary disease in dogs, pyoderma is prevalent as include hormonal diseases (such as hypothyroidism, a secondary condition of skin disease with hyperadrenocorticism or Cushing‘s allergies, parasitic infestations, endocrine syndrome, hyperestrogenism, and Sertoli cell diseases and keratinization disorders. Depending tumour) and hair follicle dystrophy/dysplasias on the depth of the infection, pyoderma is classified (dilute colour alopecia) and alopecia X. Non-inflam- into surface pyoderma (pyotraumatic dermatitis, matory alopecia usually appears symmetrical, in the intertrigo), superficial pyoderma (impetigo, absence of other skin lesions and without pruritus. mucocutaneous pyoderma, bacterial folliculitis) But pruritus may occur if secondary infections de- and deep pyoderma (interdigital furunculosis, velop (bacterial infections, Malassezia dermatitis). pyotraumatic furunculosis, nasal furunculosis). It is essential to obtain the initial clinical picture of Pyoderma appears clinically with inflammatory skin changes and evaluate this with the clinical non-symmetrical alopecia, epidermal collarettes, history and existing skin changes to make the exfoliative dermatitis, papules, pustules, crusts, etc. differential diagnosis. The diagnostic tests of choice Diagnostic tests include cytology, bacterial are trichography, cytology (to rule out secondary culture and antibiogram to select the antibiotic, infections), laboratory tests (including specific and in deep infection, a biopsy maybe indicated. diagnostic tests) and, if necessary, a biopsy (Fig. 2). Antiseptic preparations such as chlorhexidine shampoo are used for topical treatment. Empirical Hypothyroidism selection of cephalexin or amoxicillin-clavulanic acid, for systemic therapy, can be done in Hypothyroidism is the most common cause of non-complex superficial infections. Treatment symmetric non-inflammatory alopecia in dogs. In should be maintained for at least 3 weeks or up addition to the classic skin changes (non-inflam- to a week after the lesions resolve. Bacterial matory symmetric alopecia) 60 – 80% of cases culture and antibiogram are necessary in deep present with secondary infections. Other typical pyoderma, unsuccessful therapies, immunocom- clinical signs of hypothyroidism are observed, such promised patients and when cytology shows the as weight gain, bradycardia, lethargy, apathy, presence of rod bacteria. infertility, disorders of the libido and hypothermia. Blood parameters such as cholesterol, ALP, ALT and creatine kinase may be elevated and there may Figure 2: Diagnostic algorithmFig. 2: for Diagnosticnon-inflammatory alopeciaalgorithm for non-inflammatory alopecia Clinical history, clinical and dermatological examination Non-inflammatory alopecia Clarification of endocriopathies: Tricography - hypothyroidism (T4-fT4, TSH) - Cushing's syndrome (ACTH stimulation test, low-dose dexamethasone suppression test ...), Negative - sertoli cell tumor, hyperestrogenism (ultrasound) Distrubance
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