Attachment 2 Count of drugs with anticholinergic properties Jan 2007 FFS MEDICAID SENIORCARE Unduplicated Unduplicated Total Rxs/Month Pt Count Cumulative % Total Rxs/Month Pt Count Cumulative % 15 3 0.01% 12 1 0.01% 14 1 0.02% 11 1 0.01% 13 1 0.02% 10 2 0.03% 12 6 0.05% 9 2 0.04% 11 3 0.06% 8 7 0.09% 10 7 0.09% 7 7 0.15% 9 11 0.14% 6 27 0.34% 8 27 0.26% 5 41 0.64% 7 34 0.40% 4 161 1.81% 6 83 0.76% 3 552 5.82% 5 180 1.54% 2 2,373 23.08% 4 497 3.69% 1 10,581 100.00% 3 1,206 8.91% 2 4,105 26.66% Total 13,755 1 16,954 100.00%

Total 23,118

Page 1 of 3 Attachment 2 Drugs with anticholinergic properties used for data extract

DRUG NAME DRUG NAME AMANTADINE MAPROTILINE AMITRIPTYLINE MECLIZINE AMOXAPINE MEPERIDINE ANISOTROPINE MESORIDAZINE ASTEMIZOLE METHANTHELINE ATROPINE METHSCOPOLAMINE AZATADINE MIRTAZAPINE BELLADONNA MOLINDONE BENZONATATE NICOTINE BENZTROPINE NORTRIPTYLINE BIPERIDEN OLANZAPINE BROMPHENIRAMINE ORPHENADRINE BUCLIZINE OXYBUTYNIN CARBAMAZEPINE PERPHENAZINE CETIRIZINE PROCHLORPERAZINE CHLORPHENIRAMINE PROMETHAZINE CHLORPROMAZINE PROPANTHELINE CIMETIDINE PROTRIPTYLINE CLEMASTINE PYRILAMINE CLIDINIUM RANITIDINE CLOMIPRAMINE SCOPOLAMINE CLOZAPINE SOLIFENACIN CYCLIZINE TERFENADINE CYCLOBENZAPRINE THIETHYLPERAZINE CYPROHEPTADINE THIORIDAZINE DESIPRAMINE THIOTHIXENE DESLORATADINE TIOTROPIUM - INHALATION DEXCHLORPHENIRAMINE TIZANIDINE DICYCLOMINE TOLTERODINE DIFENOXIN W/ATROPINE TRAZODONE DIMENHYDRINATE TRIHEXYPHENIDYL DIPHENHYDRAMINE TRIMETHOBENZAMIDE DIPHENOXYLATE ATROPINE TRIMIPRAMINE DISOPYRAMIDE TRIPELENNAMINE DOXEPIN TROSPIUM FAMOTIDINE VARENICLINE FEXOFENADINE FLAVOXATE GLYCOPYRROLATE HALOPERIDOL HOMATROPINE HYDROXYZINE HYOSCYAMINE IMIPRAMINE IPRATROPIUM L-HYOSCYAMINE LOPERAMIDE LORATADINE LOXAPINE

Page 2 of 3 Attachment 2 Most commonly prescribed drugs with anticholinergic effects Jan 2007

FFS MEDICAID SENIORCARE Row DRUGNAME Count RXs % of RXs DRUGNAME Count RXs % of RXs Counter 1 LORATADINE 6,298 18.99% OXYBUTYNIN 2,171 11.73% 2 TRAZODONE 2,473 7.46% RANITIDINE 2,117 11.44% 3 RANITIDINE 1,951 5.88% AMITRIPTYLINE 1,585 8.57% 4 CYCLOBENZAPRINE 1,935 5.84% MIRTAZAPINE 1,533 8.28% 5 CARBAMAZEPINE 1,691 5.10% TRAZODONE 1,088 5.88% 6 DIPHENHYDRAMINE 1,387 4.18% TIOTROPIUM - INHALATION 1,049 5.67% 7 AMITRIPTYLINE 1,373 4.14% MECLIZINE 693 3.75% 8 OLANZAPINE 1,358 4.10% SOLIFENACIN 628 3.39% 9 CETIRIZINE 1,040 3.14% IPRATROPIUM 594 3.21% 10 BENZTROPINE 984 2.97% FAMOTIDINE 581 3.14% 11 MIRTAZAPINE 954 2.88% CYCLOBENZAPRINE 465 2.51% 12 OXYBUTYNIN 926 2.79% NORTRIPTYLINE 423 2.29% 13 BENZONATATE 710 2.14% TOLTERODINE 422 2.28% 14 CLOZAPINE 677 2.04% HYDROXYZINE 352 1.90% 15 HYDROXYZINE 638 1.92% CARBAMAZEPINE 348 1.88% 16 PROMETHAZINE 560 1.69% HYOSCYAMINE 344 1.86% 17 HALOPERIDOL 509 1.54% L-HYOSCYAMINE 344 1.86% 18 IPRATROPIUM 497 1.50% OLANZAPINE 333 1.80% 19 VARENICLINE 469 1.41% DIPHENOXYLATE ATROPINE 307 1.66% 20 NICOTINE 434 1.31% DOXEPIN 292 1.58% 21 MECLIZINE 408 1.23% PROCHLORPERAZINE 274 1.48% 22 FEXOFENADINE 407 1.23% BENZONATATE 272 1.47% 23 PROCHLORPERAZINE 406 1.22% CETIRIZINE 266 1.44% 24 NORTRIPTYLINE 403 1.22% FEXOFENADINE 237 1.28% 25 TIZANIDINE 390 1.18% IMIPRAMINE 225 1.22% 26 IMIPRAMINE 383 1.16% LOPERAMIDE 186 1.01% 27 FAMOTIDINE 335 1.01% TROSPIUM 126 0.68% 28 TIOTROPIUM - INHALATION 335 1.01% PROMETHAZINE 125 0.68% 29 TRIHEXYPHENIDYL 208 0.63% DICYCLOMINE 121 0.65% 30 L-HYOSCYAMINE 191 0.58% CIMETIDINE 116 0.63% 31 HYOSCYAMINE 191 0.58% HALOPERIDOL 79 0.43% 32 SOLIFENACIN 186 0.56% VARENICLINE 70 0.38% 33 LOPERAMIDE 181 0.55% TIZANIDINE 68 0.37% 34 DIPHENOXYLATE ATROPINE 177 0.53% DIPHENHYDRAMINE 64 0.35% 35 SCOPOLAMINE 171 0.52% DISOPYRAMIDE 63 0.34% 36 DOXEPIN 168 0.51% BENZTROPINE 610.33% 37 DICYCLOMINE 163 0.49% SCOPOLAMINE 55 0.30% 38 GLYCOPYRROLATE 151 0.46% AMANTADINE 49 0.26% 39 TOLTERODINE 149 0.45% THIORIDAZINE 35 0.19% 40 AMANTADINE 140 0.42% TRIHEXYPHENIDYL 35 0.19% 41 CLOMIPRAMINE 139 0.42% DESLORATADINE 34 0.18% 42 CYPROHEPTADINE 123 0.37% NICOTINE 32 0.17% 43 ORPHENADRINE 111 0.33% ORPHENADRINE 27 0.15% 44 THIOTHIXENE 97 0.29% DESIPRAMINE 27 0.15% 45 CHLORPROMAZINE 94 0.28% ATROPINE 23 0.12% 46 THIORIDAZINE 92 0.28% CHLORPROMAZINE 18 0.10% 47 DESLORATADINE 74 0.22% TRIMETHOBENZAMIDE 15 0.08% 48 LOXAPINE 68 0.21% GLYCOPYRROLATE 15 0.08% 49 CIMETIDINE 67 0.20% CLOMIPRAMINE 14 0.08% 50 DESIPRAMINE 53 0.16% CYPROHEPTADINE 14 0.08% 51 TROSPIUM 48 0.14% THIOTHIXENE 13 0.07% 52 PERPHENAZINE 40 0.12% PERPHENAZINE 8 0.04% 53 ATROPINE 29 0.09% TRIMIPRAMINE 8 0.04% 54 MOLINDONE 22 0.07% MAPROTILINE 8 0.04% 55 MEPERIDINE 17 0.05% CLOZAPINE 8 0.04% 56 TRIMETHOBENZAMIDE 17 0.05% LOXAPINE 8 0.04% 57 CLEMASTINE 9 0.03% CHLORPHENIRAMINE 60.03% 58 PROTRIPTYLINE 8 0.02% FLAVOXATE 5 0.03% 59 MAPROTILINE 7 0.02% AMOXAPINE 4 0.02% 60 FLAVOXATE 7 0.02% MEPERIDINE 4 0.02% 61 HOMATROPINE 5 0.02% CLEMASTINE 4 0.02% 62 AMOXAPINE 5 0.02% HOMATROPINE 3 0.02% 63 BIPERIDEN 5 0.02% DEXCHLORPHENIRAMINE 3 0.02% 64 DISOPYRAMIDE 4 0.01% PROTRIPTYLINE 2 0.01% 65 TRIMIPRAMINE 3 0.01% BELLADONNA 2 0.01% 66 CHLORPHENIRAMINE 3 0.01% PROPANTHELINE 1 0.01% 67 DIMENHYDRINATE 3 0.01% BROMPHENIRAMINE 1 0.01% 68 PROPANTHELINE 2 0.01% MOLINDONE 1 0.01%

Total Rxs 33,159 Total Rxs 18,504

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