1 Case Study: Lise Meitner 1944 Nobel Prize in Chemistry Awarded

Total Page:16

File Type:pdf, Size:1020Kb

1 Case Study: Lise Meitner 1944 Nobel Prize in Chemistry Awarded Case study: Lise Meitner 1944 Nobel Prize in Chemistry awarded to collaborator Otto Hahn After finishing her Ph.D. degree, Lise Mietner moved to Berlin, Germany. She came to study physics with Max Plank. This was where she met Otto Hahn. Hahn was working with famous chemist Emil Fischer when he met Lise Meitner. At that time, Fischer did not allow women in his laboratory. Instead, Hahn and Meitner created a workshop in the basement of the Chemical Institute just for Lise to work in. For 15 years Lise Mietner and Otto Hahn worked together. Then, in 1920, they decided to separate their research projects. They worked together very closely in the lab but they were very formal outside of the lab. Otto Hahn respected Meitner’s research but he would not stand up for her if anyone questioned it. However, Mietner’s other friends and peers (including Albert Einstein) saw her as the leader of the research group. In 1934, Meitner asked Hahn and Fritz Strassmann for help with some experiments. She wanted to work on making new elements that were beyond uranium on the periodic table. This was the research for which Hahn would eventually win the Nobel Prize. The 1930s were a very difficult time for Lise Meitner because she had a Jewish background (her grandparents were Jews who had converted to Lutheranism). In Germany at this time, anyone who had “Jewish blood” was discriminated against and in danger of losing their position. Because of this, she could not present her own work. When Hahn presented their work, he could not mention Mietner’s name out of fear it would get him in trouble as well. Finally, it became clear to Meitner that she had leave Germany. In 1938, she moved to Sweden so that she could keep working. Before Mietner left Germany, Hahn and Strassmann did experiments which seemed to show the nuclei of uranium atoms had been split into smaller nuclei. This was a very surprising result! While Mietner was in Sweden, she continued to write to Hahn about their uranium investigation. She started working with her nephew, Otto Frisch, and quickly had an idea for what was happening to the uranium atoms. She calculated her result and told Hahn; this was the first time that anyone proposed the idea of nuclear fission (when a neutron can be used to split an atom’s nucleus into smaller pieces). She then sent urgent instructions to Hahn and Strassmann for how to carry out an experiment to confirm her ideas. Hahn and Strassmann left out Lise Mietner when they published a paper explaining their work. Right afterwards, Mietner and Frisch published a paper describing the process of “fission.” Hahn left out Meitner because he wanted to protect himself and his workplace. He won the Nobel Prize in Chemistry in 1944 for the discovery of nuclear fission. Even though Mietner did not win the Nobel Prize, she did win some other awards. In 1966 she shared the Fermi Prize of Atomic Energy Commission with Hahn and Strassmann. During World War II, she was also asked to join the scientists working on the atomic bomb. She refused and hoped that the project would not work. However, she was often asked for interviews about nuclear topics. Hahn did not like people claiming he should not have received the full prize, and sent out a statement to the press saying that Meitner was not involved with his Nobel-winning work. Photo by Robert R. Davis, AIP Emilio Segre Visual Archives, Physics Today Collection 1 Case Study: Chien-Shiung Wu 1957 Nobel Prize in Physics awarded to collaborators Tsung Dao Lee and Chen Ning Yang Chien-Shiung Wu came to the United States in 1936 from China. She completed her Ph.D. work at the University of California-Berkeley. While working on her degree, she became a leading scientist in nuclear fission (a part of particle physics). Many top scientists would ask her questions, including Enrico Fermi. After she graduated, Wu moved to Columbia University. She focused her research on beta decay, a type of nuclear radiation. She was well-known for her careful and reliable experiments. She expected that all of the graduate students working with her would be as careful as she was. Even though she was known as a great researcher, she was often discriminated against based on her gender and nationality. This meant that she was not considered for many promotion opportunities. She was one of the few scientists asked to stay at Columbia after the war to continue working on the Manhattan Project. In 1952, she was finally promoted from a researcher to a professor at Columbia University. At this time, particle physics was quickly growing and many new particles were being discovered. Two of the particles discovered were the tau meson and the theta meson. These particles had the same properties but would break down into different things. This violated Fermi’s Law of Parity (a physics law that said physical events should be symmetrical with their mirror images). Then scientists Tsung Dao Lee and Chen Ning realized that no experiments had been done to actually confirm this law in small particles. They published a paper about how this experiment could be performed. Knowing that Wu had a lot of knowledge in this area, Lee asked her to put together a team and perform the difficult experiment. In 1957, Wu announced her result that Law of Parity did not work for small particles. The group published a paper about their work and Wu was listed as the first name on the paper. In 1957 Yang and Lee won the Nobel the Prize in physics for their paper that thought up Wu’s experiment. Many people, including Wu, thought that she should have been also awarded the prize. She was not awarded the prize with them because the Nobel Prize committee said that her work was not a “discovery or invention.” However, she was soon promoted to a full professor at Columbia University and many universities gave her honorary degrees later in her life. She was also the first woman to serve as the president of the American Physical Society. AIP Emilio Segre Visual Archives, Physics Today Collection 2 Case Study: Marietta Blau 1950 Nobel Prize in Physics awarded to Cecil Powell Marietta Blau was a physicist who studied particles and who played an important role in developing photographic techniques to detect particles. She finished her Ph.D. in 1919 at the University of Vienna, but could not find a research job that would pay her. She decided to continue her own research and became an unpaid volunteer at the Institute for Radium Research in Vienna. This was where she did some groundbreaking research photographic emulsions – pictures which would show the disintegration of particles. She asked Hertha Wambacher, a graduate student, to help her with the research. Together they discovered cosmic ray “stars” – small patterns of particle paths that occur when a cosmic ray hits an atom’s nucleus. Marietta Blau also worked on identifying other types of particles in the photos. Blau faced discrimination because of her gender and Jewish religion. Hitler took control of Austria in 1938. At this time, Blau was working in Norway. She would not be allowed back home, and was forced to move away from Norway in order to stay safe. Albert Einstein helped Blau become a professor in Mexico City by writing her a letter of recommendation. Along the way to Mexico, her scientific papers were taken by Nazi officials. Some of these papers included plans for her future research. Later on, her ideas were published in a paper by Wambacher and G. Stetter. Wambacher had worked with Blau before and both she and Stetter supported the Nazi party. Blau spent a few years in Mexico. In 1944 she moved to the United States to continue her research. In 1950, Cecil Powell won the Nobel Prize for physics for applications of the photographic method that Blau developed early in her career. Powell decided to make this his field of research once he had been alerted to Blau and Wambacher’s previous research of the topic. Blau was also nominated for the 1950 Nobel Prize due to her development of photographic nuclear emulsions but was not mentioned in the official report. AIP Emilio Segre Visual Archives, Gift of Eva Connors 3 Case Study: S. Jocelyn Bell Burnell 1974 Nobel Prize in Physics awarded to Martin Ryle and Antony Hewish Susan Jocelyn Bell Burnell started her graduate studies in 1965 at Cambridge University under the guidance of Antony Hewish. He was working on designing a telescope to detect “twinkling” radio signals from stars. Jocelyn Burnell and other students helped build the telescope over a span of two years. Burnell was the only one to run the telescope and analyze data. She was 24 years old and a graduate student when she first observed a pulsar. A pulsar is a type of star that emits radio signals which are evenly spaced. In October 1967 Burnell noticed signals that looked different than quasar signals or interference from other places. At first, her mentor thought that the signals were man made. They even thought that there could be an alien source for the signals. Then Burnell determined that the unusual signals were not aliens. She found a few different sources of the same type of signals in different places in the sky. In 1968 they published a paper about the discovery with Hewish as the first author listed. Burnell was the second author listed on the paper out of five people.
Recommended publications
  • Hitler and Heisenberg
    The Wall Street Journal December 27-28, 2014 Book Review “Serving the Reich” by Philip Ball, Chicago, $30, 303 pages Hitler and Heisenberg Werner Heisenberg thought that once Germany had won, the ‘good Germans’ would get rid of the Nazis. Fizzing The museum inside the former basement tavern where in early 1945 German scientists built a small nuclear reactor. Associated Press by Jeremy Bernstein The German scientists who remained in Germany throughout the Nazi period can be divided into three main groups. At one end were the anti-Nazis—people who not only despised the regime but tried to do something about it. They were very few. Two that come to mind were Fritz Strassmann and Max von Laue. Strassmann was a radiochemist—a specialist in radioactive materials—who was blacklisted from university jobs by the Society of German Chemists in 1933 for his anti-Nazi views. He was fortunate to get a half-pay job at the Kaiser Wilhelm Institute for Chemistry, which got some of its funding from industry. He and his wife (they had a 3-year-old son) hid a Jewish friend in their apartment for months. With the radiochemist Otto Hahn, he performed the 1938 experiment in which fission was observed for the first time. Von Laue won the Nobel Prize in physics in 1914. Soon after Einstein published his 1905 paper on relativity, von Laue went to Switzerland to see him. They remained friends for life. Under the Nazis, Einstein’s work was denounced as “Jewish science.” When a number of von Laue’s colleagues agreed to use relativity but attribute it to some Aryan, he refused.
    [Show full text]
  • The Pedersen Memorial Issue
    springer.com Chemistry : Organic Chemistry The Pedersen Memorial Issue Foreword: Charles J. Pedersen (1904-1989), Nobel Laureate in Chemistry (1987) This issue is dedicated to the memory of the late Charles J. Pedersen in recognition of his outstanding contribution to scientific research, culminating in his discovery of crown ethers and their remarkable cation complexing properties and his receipt of the 1987 Nobel Prize in Chemistry. Charlie's origin and early years in Korea did not portend the creative work in chemistry which would characterize his later life. However, we can see in his early years the influence of his Norwegian father and Japanese mother who considered his formal education to be of utmost importance. At the age of eight, he was sent abroad to Japan for schooling, first at a convent school in Nagasaki, and two years later at a French-American preparatory school in Yokohama run by a Marianist order of Catholic priests and brothers. The latter group encouraged him to attend the order's University of Dayton in Ohio where he received a bachelors degree in Springer chemical engineering. Charlie's academic experiences, his employment with du Pont, and the Softcover reprint of the creative spark which he manifested at an early stage of his scientific career are detailed in the 1st original 1st ed. 1992, VI, paper in this issue by Herman Schroeder. Schroeder had a long-time association with Charlie at edition 406 p. du Pont as a co-worker, supervisor, and friend. His recollections provide insight into Charlie's creative mind. In addition, they make it clear that a long period of creative work preceded the accidental discovery of the first synthetic crown ether.
    [Show full text]
  • What Use Is Chemistry?
    2 Inspirational chemistry What use is chemistry? Index 1.1 1 sheet This activity is based on a Sunday Times article by Sir Harry Kroto, a Nobel prize winning chemist who discovered a new allotrope of carbon – buckminsterfullerene or ‘bucky balls’. The article appeared on November 28, 2004 and is reproduced overleaf as a background for teachers. The aim is to introduce students to the scope of modern chemistry and the impact that it has on their lives, even in areas that they may not think of as related to chemistry. An alternative exercise for more able students would be to research what was used before chemical scientists had produced a particular new product or material (eg silk or wool stockings before nylon, leather footballs before synthetics, grated carbolic soap before shampoo) and then to write about the difference it would make to their lives if they did not have the modern product. Students will need: ■ Plenty of old magazines and catalogues (Argos catalogues are good as virtually everything in them would not exist without modern chemistry) ■ Large sheets of sugar paper ■ Glue and scissors. It works well if students produce the poster in groups, but then do the written work by themselves. The activity could be set for homework. Inspirational chemistry 3 What use is chemistry? Some years ago I was delighted chemistry-related industries make a to receive an honorary degree £5 billion profit on a £50 billion from Exeter University turnover, the apparent government recognising my contributions to inaction over the looming disaster chemistry – especially the is scarcely credible.
    [Show full text]
  • The 2016 Nobel Prize in Chemistry
    Pure Appl. Chem. 2016; 88(10-11): 917–918 Editorial Hugh D. Burrows* and Richard M. Hartshorn* The 2016 Nobel Prize in Chemistry DOI 10.1515/pac-2016-2005 Keywords: Ben L. Feringa; Jean-Pierre Sauvage; J. Fraser Stoddart; Nobel Prize in Chemistry; 2016. Pure and Applied Chemistry warmly congratulates Jean-Pierre Sauvage (University of Strasbourg, France), Sir J. Fraser Stoddart (Northwestern University, Evanston, IL, USA), and Bernard (Ben) L. Feringa (Univer- sity of Groningen, the Netherlands) on their award of the 2016 Nobel Prize in Chemistry. The citation from the Royal Swedish Academy of Sciences states that the award is “for the design and synthesis of molecu- lar machines”. Their work encompasses a broad spectrum of Chemistry, from elegant synthetic studies of catenanes, rotaxanes and other formerly considered exotic molecules, through coordination chemistry, and electron transfer reactions, to molecular switches and rotors driven by light and other external sources. They have all participated actively in IUPAC endorsed meetings and conference series, including the IUPAC World Congress in Chemistry, IUPAC International Conferences on Organic Synthesis (ICOS), Physical Organic Chemistry (ICPOC), and Coordination Chemistry (ICCC), and IUPAC International Symposia on Macrocyclic Chemistry (ISMC), Organometallic Chemistry Directed Towards Organic Synthesis (OMCOS), Novel Aromatic Compounds (ISNA), Carbohydrate Chemistry (ICS), the Chemistry of Natural Products ISCNP), and Photo- chemistry. Pure Appl. Chem. publishes collections of papers based upon authoritative lectures presented at such IUPAC endorsed events, in addition to IUPAC Recommendations, and Technical Reports. We are very pleased to highlight the following publications from these three Nobel Laureates that have been published in Pure and Applied Chemistry as a result of their involvement in these conferences.
    [Show full text]
  • The Lock-And-Key Analogy in 20Th Century Biochemistry
    From: Rebecca Mertens The Construction of Analogy-Based Research Programs The Lock-and-Key Analogy in 20th Century Biochemistry April 2019, 224 p., pb., ill. 34,99 € (DE), 978-3-8376-4442-5 E-Book: PDF: 34,99 € (DE), ISBN 978-3-8394-4442-9 When the German chemist Emil Fischer presented his lock-and-key hypothesis in 1899, his analogy to describe the molecular relationship between enzymes and substrates quickly gained vast influence and provided future generations of scientists with a tool to investigate the relation between chemical structure and biological specificity. Rebecca Mertens explains the appeal of the lock-and-key analogy by its role in model building and in the construction of long-term, cross-generational research programs. She argues that a crucial feature of these research programs, namely ascertaining the continuity of core ideas and concepts, is provided by a certain way of analogy-based modelling. Rebecca Mertens (PhD), born in 1984, is a postdoctoral researcher in the history and philosophy of science at the University of Bielefeld, Germany. She works on the role of analogies, models and forms of comparison in the history of molecular genetics and is a member of the collaborative research program "Practices of ComparisonÚ Ordering and Changing the World". During her graduate and doctoral studies, she was a visiting scholar at the École Normale Supérieure in Paris and a visiting graduate fellow at the Minnesota Center for Philosophy of Science. For further information: www.transcript-verlag.de/en/978-3-8376-4442-5 © 2019
    [Show full text]
  • Cambridge's 92 Nobel Prize Winners Part 2 - 1951 to 1974: from Crick and Watson to Dorothy Hodgkin
    Cambridge's 92 Nobel Prize winners part 2 - 1951 to 1974: from Crick and Watson to Dorothy Hodgkin By Cambridge News | Posted: January 18, 2016 By Adam Care The News has been rounding up all of Cambridge's 92 Nobel Laureates, celebrating over 100 years of scientific and social innovation. ADVERTISING In this installment we move from 1951 to 1974, a period which saw a host of dramatic breakthroughs, in biology, atomic science, the discovery of pulsars and theories of global trade. It's also a period which saw The Eagle pub come to national prominence and the appearance of the first female name in Cambridge University's long Nobel history. The Gender Pay Gap Sale! Shop Online to get 13.9% off From 8 - 11 March, get 13.9% off 1,000s of items, it highlights the pay gap between men & women in the UK. Shop the Gender Pay Gap Sale – now. Promoted by Oxfam 1. 1951 Ernest Walton, Trinity College: Nobel Prize in Physics, for using accelerated particles to study atomic nuclei 2. 1951 John Cockcroft, St John's / Churchill Colleges: Nobel Prize in Physics, for using accelerated particles to study atomic nuclei Walton and Cockcroft shared the 1951 physics prize after they famously 'split the atom' in Cambridge 1932, ushering in the nuclear age with their particle accelerator, the Cockcroft-Walton generator. In later years Walton returned to his native Ireland, as a fellow of Trinity College Dublin, while in 1951 Cockcroft became the first master of Churchill College, where he died 16 years later. 3. 1952 Archer Martin, Peterhouse: Nobel Prize in Chemistry, for developing partition chromatography 4.
    [Show full text]
  • Marietta Blau in the History of Cosmic Rays Per Carlson
    Physics Today Marietta Blau in the history of cosmic rays Per Carlson Citation: Physics Today 65(10), 8 (2012); doi: 10.1063/PT.3.1729 View online: http://dx.doi.org/10.1063/PT.3.1729 View Table of Contents: http://scitation.aip.org/content/aip/magazine/physicstoday/65/10?ver=pdfcov Published by the AIP Publishing Reuse of AIP Publishing content is subject to the terms at: https://publishing.aip.org/authors/rights-and-permissions. Download to IP: 149.28.91.2 On: Thu, 30 Jun 2016 17:53:16 readers’ forum Marietta Blau in the history of cosmic rays er Carlson, in his article “A century have been formed by cosmic particles ex- contributions deserve a prominent and Pof cosmic rays” (PHYSICS TODAY, plosively disintegrating heavy nuclei in permanent place in any history of February 2012, page 30), states that the emulsion. That discovery, in 1937, cosmic-ray and particle physics. And I the investigation of cosmic rays opened created a sensation among nuclear and believe it is also important, given the up the field of particle physics. How- cosmic-ray physicists worldwide, and by much-discussed problem of the under- ever, he neglects the importance of nu- demonstrating that nuclear emulsions representation of women in physics, clear emulsions in the progress of par- had come of age for recording rare high- that PHYSICS TODAY take care not to ticle physics, and he fails to mention a energy nuclear events, it paved the way overlook women who, like Blau, made key figure, Austrian physicist Marietta for further research in particle physics.
    [Show full text]
  • Antony Hewish
    PULSARS AND HIGH DENSITY PHYSICS Nobel Lecture, December 12, 1974 by A NTONY H E W I S H University of Cambridge, Cavendish Laboratory, Cambridge, England D ISCOVERY OF P U L S A R S The trail which ultimately led to the first pulsar began in 1948 when I joined Ryle’s small research team and became interested in the general problem of the propagation of radiation through irregular transparent media. We are all familiar with the twinkling of visible stars and my task was to understand why radio stars also twinkled. I was fortunate to have been taught by Ratcliffe, who first showed me the power of Fourier techniques in dealing with such diffraction phenomena. By a modest extension of existing theory I was able to show that our radio stars twinkled because of plasma clouds in the ionosphere at heights around 300 km, and I was also able to measure the speed of ionospheric winds in this region (1) . My fascination in using extra-terrestrial radio sources for studying the intervening plasma next brought me to the solar corona. From observations of the angular scattering of radiation passing through the corona, using simple radio interferometers, I was eventually able to trace the solar atmo- sphere out to one half the radius of the Earth’s orbit (2). In my notebook for 1954 there is a comment that, if radio sources were of small enough angular size, they would illuminate the solar atmosphere with sufficient coherence to produce interference patterns at the Earth which would be detectable as a very rapid fluctuation of intensity.
    [Show full text]
  • Marietta Blau's Work After World War II Arnold Perlmutter Department Of
    View metadata, citation and similar papers at core.ac.uk brought to you by CORE provided by CERN Document Server Marietta Blau's Work After World War II Arnold Perlmutter Department of Physics University of Miami Coral Gables, Florida 33124 completed, October 27, 2000 This paper has been translated into German and will be included, in a somewhat altered form, in a book Sterne der Zertrummerung, Marietta Blau, Wegbereiterin der Moderne Teilchenphysik, Brigitte Strohmaier and Robert Rosner, eds., Boehlau Verlag, Wien. 1 A. Introduction While it is clear that the seminal work of Dr. Marietta Blau was done in the 1920’s and especially in the 1930’s, it is also evident that her separation from the great research centers from 1938 to 1944 had a devastating effect on her productivity. It was during this period that Cecil F. Powell, at Bristol University, made use of Blau’s earlier tutelage on the preparation and analysis of photographic emulsions. According to Blau’s conversations with me (much later), she consulted with Ilford in the 1930’s to improve emulsion sensitivity and uniformity, and presumably had also imparted crucial lore of the technique to Powell. C.F. Powell, who had been a student of C.T.R. Wilson, had employed cloud chambers in a wide variety of studies in vulcanology, mechanical engineering, and nuclear physics. In 1938 and 1939 Powell’s experimental efforts turned to the use of photographic emulsions to investigate neutron interactions, and then to nuclear reactions1. With the coming of the war and then the British nuclear atomic bomb project, Powell established a formidable laboratory and collaboration for the analysis of emulsions and for their improvement by Ilford and Kodak.
    [Show full text]
  • Chartered Status Charteredeverything You Need Tostatus Know Everything You Need to Know
    Chartered Status CharteredEverything you need toStatus know Everything you need to know www.rsc.org/cchem www.rsc.org/cchem ‘The best of any profession is always chartered’ The RSC would like to thank its members (pictured top to bottom) Ben Greener, Pfizer, Elaine Baxter, Procter & Gamble, and Richard Sleeman, Mass Spec Analytical Ltd, for their participation and support . Chartered Status | 1 Contents About chartered status 3 Why become chartered? 3 What skills and experience do I need? 3 The professional attributes for a Chartered Chemist 5 Supporting you throughout the programme yThe Professional Development Programme 5 yThe Direct Programme 7 How to apply 7 Achieving Chartered Scientist status 8 Revalidation 8 The next step 8 Application form 9 2 | Chartered Status ‘Having a professionally recognised qualification will build my external credibility’ Elaine Baxter BSc PhD MRSC Procter & Gamble Elaine Baxter is a Senior Scientist at Procter & Gamble (P&G). Since joining the company, she has had roles in formulation, process and technology development in skin and shaving science. She graduated in 2001, before completing a PhD on synthetic inorganic chemistry of platinum dyes with applications in solar cells. Elaine is currently working towards Chartered Chemist status through the Professional Development Programme. Why do you want to achieve Chartered Chemist status? My role involves science communication with people such as dermatologists, academics and the media; having a professionally recognised qualification will build my external credibility with these professionals. How do you feel the programme has worked for you? Working towards achieving the attributes required for the CChem award has presented me with opportunities to share my industry knowledge and help others.
    [Show full text]
  • Pauling-Linus.Pdf
    NATIONAL ACADEMY OF SCIENCES L I N U S C A R L P A U L I N G 1901—1994 A Biographical Memoir by J A C K D. D UNITZ Any opinions expressed in this memoir are those of the author(s) and do not necessarily reflect the views of the National Academy of Sciences. Biographical Memoir COPYRIGHT 1997 NATIONAL ACADEMIES PRESS WASHINGTON D.C. LINUS CARL PAULING February 28, 1901–August 19, 1994 BY JACK D. DUNITZ INUS CARL PAULING was born in Portland, Oregon, on LFebruary 28, 1901, and died at his ranch at Big Sur, California, on August 19, 1994. In 1922 he married Ava Helen Miller (died 1981), who bore him four children: Linus Carl, Peter Jeffress, Linda Helen (Kamb), and Edward Crellin. Pauling is widely considered the greatest chemist of this century. Most scientists create a niche for themselves, an area where they feel secure, but Pauling had an enormously wide range of scientific interests: quantum mechanics, crys- tallography, mineralogy, structural chemistry, anesthesia, immunology, medicine, evolution. In all these fields and especially in the border regions between them, he saw where the problems lay, and, backed by his speedy assimilation of the essential facts and by his prodigious memory, he made distinctive and decisive contributions. He is best known, perhaps, for his insights into chemical bonding, for the discovery of the principal elements of protein secondary structure, the alpha-helix and the beta-sheet, and for the first identification of a molecular disease (sickle-cell ane- mia), but there are a multitude of other important contri- This biographical memoir was prepared for publication by both The Royal Society of London and the National Academy of Sciences of the United States of America.
    [Show full text]
  • Antibodies with Some Bite Antibodies Have Yet to Be Determined, It Is Reasonable to Suppose That the Ester Or David E
    -~-------------------------------------N8NSANDVIEWS----------------_N_A_TU_R_E_V-O_L_._32_5_22_J_A_N_U_A_RY__ 19~87 Enzyme catalysis kinetics and is subject to competitive inhibition. Although the detailed chemical mechanisms of these catalytic Antibodies with some bite antibodies have yet to be determined, it is reasonable to suppose that the ester or David E. Hansen carbamate is strained towards a tetra­ hedral geometry on binding, thus facilitat­ THE spectacular specificities and rate William Jencks', more directly, stated in ing the attack of the hydroxide ion. Fur­ enhancements of enzymes are without 1969 thermore, the Scripps group has already equal among all known catalysts. It is no If complementarity between active site and found that their antibody can act via both wonder then that the design of new en­ transition state contributes significantly to nucleophilic and general base catalysis, zymes has long been a goal of biochemists. enzyme catalysis, it should be possible to syn­ depending on the substrate used. Now two independent groups, one led by thesize an enzyme by constructing a binding The fact that this approach succeeded at Alfonso Tramontano and Richard Lerner site. One way to do this is to prepare an anti­ all gives great hope to those attempting to of the Scripps Clinic and Research Foun­ body to a haptenic group which resembles the isolate even more efficient antibody cat­ dation', and the other by Peter Schultz of transition state of a given reaction. The com­ alysts by this and by other strategies. In the University of California at Berkeley\ bining sites of such antibodies should be com­ addition, it may be possible to modify have taken steps towards this goal by plementary to the transition state and should cause an acceleration by forcing bound sub­ existing catalytic antibodies.
    [Show full text]