Metergoline
Product Number M 3668 Storage Temperature -20 °C
Product Description Precautions and Disclaimer Molecular Formula: C25H29N3O2 For Laboratory Use Only. Not for drug, household or Molecular Weight: 403.5 other uses. CAS Number: 17692-51-2 Melting point: 146-149 °C1 Preparation Instructions Extinction coefficient: E1% = 165 (291 nm)1 Metergoline is soluble in chloroform (50 mg/ml). Metergoline is very soluble in pyridine and soluble in Metergoline is an ergot derivative or ergoline and is a alcohol and acetone. It is practically insoluble in 1 dopamine agonist with actions and uses similar to that benzene, ether, and water. of bromocriptine. It is also a serotonin antagonist and has been used similarly to bromocriptine.2 References 1. The Merck Index, 12th ed., Entry# 5999. Metergoline, a putative 5-HT1 receptor antagonist, did 2. Martindale The Extra Pharmacopoeia, 30th ed., not block the effects of 5-hydroxytryptamine (5-HT) Reynolds, J. E. F., ed., The Pharmaceutical Press and was found to be acting as a full agonist at the (London, England: 1993), p. 848. 5-HT1D b receptor.3 3. Miller, K. J., et al., Agonist activity of sumatriptan and metergoline at the human 5-HT1D b receptor: To test the hypothesis that the suppression of fat further evidence for a role of the 5-HT1D receptor selection and/or consumption by systemic serotonin in the action of sumatriptan. Eur. J. Pharmacol., agonists involves stimulation of central 5-HT 227(1), 99-102 (1992). receptors, a series of experiments was performed in 4. Smith, B. K., et al., Activation of hypothalamic nondeprived rats. In one experiment, third serotonin receptors reduced intake of dietary fat cerebroventricular (3V) infusion of the nonselective and protein but not carbohydrate. Am. J. Physiol., 5-HT antagonist metergoline prevented the reduction 277(3 Pt 2), R802-R811 (1999). in fat, but not carbohydrate feeding caused by 5. Yamada, J., et al., Effects of the non-selective systemic dexfenfluramine. Furthermore, 3V 5-HT receptor agonist, 5-carboxamidotryptamine, metergoline alone increased fat intake.4 on plasma glucose levels in rats. Eur. J. Pharmacol., 359(1), 81-86 (1998). Hyperglycemia induced by 5-carboxamidotryptamine 5 was prevented by pretreatment with metergoline. HLD/RXR 9/07
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