UNICANCER – Department ofcommunications–November 2014 UNICANCER –Department UNICANCER invents the oncology of tomorrow The international cooperations of the French Comprehensive Cancer Centers

Group of the French Comprehensive Cancer Centers www.unicancer.fr The UNICANCER Group, a key player 20 Centers exclusively dedicated to in oncology in treating cancer UNICANCER groups together the 20 French Comprehensive Cancer Centers (FCCC). It promotes The French Comprehensive Cancer Centers (FCCC) are at the cutting edge of oncology. They the cancer research organizational model and pools their resources and expertise in order to bring are private, non-profit establishments dedicated exclusively to healthcare, research and a new dynamic to the management of patients. teaching in oncology. They have adopted an innovative patient management model, based on the research/care continuum.

NORTH-WEST NORTH-EAST The In France Lille UNICANCER model: Centre Oscar Lambret Institut régional du cancer Centre Georges-François Leclerc are treated www.centreoscarlambret.fr de Montpellier – Val d’Aurelle www.cgfl.fr • Multi-disciplinary www.icm.unicancer.fr in the FCCC: • Comprehensive care Rouen Reims Centre Henri Becquerel Institut de Cancérologie Jean Godinot of the patient PACA (Provence, Alps, Côte-d’Azur) of the women with www.centre-henri-becquerel.fr www.institutjeangodinot.fr • Research/care continuum 30 % breast cancer Caen Nancy Institut Paoli-Calmettes • Performance and innovation Centre François Baclesse Institut de Cancérologie de Lorraine of the women with for the benefit of patients www.institutpaolicalmettes.fr gynecological forms of cancer www.baclesse.fr Alexis Vautrin 20 % www.icl-lorraine.fr • Treatments accessible Nice of the patients with AND SUBURBS Centre Antoine Lacassagne to all respecting the fees Strasbourg Ear-Nose-Throat cancer www.centreantoinelacassagne.org 19 % set by the social Centre Paul Strauss Paris – Saint-Cloud of the patients with security The hospitals of the Institut Curie www.centre-paul-strauss.fr 21 % endocrine cancer encompassing 2 FCCC LARA (, Auvergne, Rhône-Alpes) • Hôpital parisien • Hôpital René Huguenin Lyon (Saint-Cloud) Centre Léon Bérard For patients and the medical UNICANCER in figures: www.curie.fr www.centreleonberard.fr and scientific world alike, the Clermont-Ferrand Villejuif UNICANCER brand serves as a Gustave Roussy Centre Jean Perrin label helping them to situate themselves 20 www.gustaveroussy.fr www.cjp.fr within the complex healthcare offer in on- healthcare cology. establishments WEST UNICANCER guarantees the same quality of management in all of the Group’s esta- Rennes blishments, as well as fast, safe access to Centre Eugène Marquis 18 000 www.centre-eugene-marquis.fr innovations. Research is at the heart of the employees UNICANCER Group and its aim is to put in- Angers-Nantes novation at the service of patients. L’Institut de Cancérologie + 110 000 de l’Ouest (ICO) encompassing patients hospitalized 2 FCCC: • ICO site Paul Papin (Angers) UNICANCER abroad every year • ICO site René Gauducheau (Nantes) UNICANCER is a member of two www.ico-cancer.fr international federations and one + 250 world organisation: clinical trials sponsored SOUTH-WEST • International Hospital Federation (IHF). by the Group Bordeaux • European Hospital and Healthcare Institut Bergonié Federation (Hope). www.bergonie.org

• Union for International Cancer Toulouse Control (UICC). 2 b. € Institut universitaire du cancer billion in total revenue de Toulouse – Oncopole (IUCT) www.claudiusregaud.fr The expertise of the French comprehensive cancer Innovative The innovative equipment that makes it centers in terms possible to perform the most technical effective treatments is for the most part installed in the FCCC. of healthcare platforms for 44% of the particle accelerators have been acquired or renewed in The French Comprehensive Cancer Centers (FCCC) ensure the the benefit the last four years. Of the 20 Centers, management of all types of cancer: 13 now have tomotherapy * equipment, 6 are equipped • Standard forms of cancer (breast cancer, prostate cancer, gynecological of patients with Novalis and 5 with cancers, lung cancer, cancer of the digestive tract, etc.). Cyberknife. • Rare forms of cancer (Ear-Nose-Throat cancers, soft tissue cancer, etc.). • Complex cases.

Individualized and innovative UNICANCER, expertise patient management recognized by the public * UNICANCER puts the concepts of quality of mana- authorities gement, quality in the doctor-patient relationship The French Comprehensive Cancer Centers are the and quality of life at the heart of its strategy. privileged partners for many of the trials developed • Individualized treatments: adapting treatment under the Cancer Plan and financed by the French go- to the biological specificities of patients and their vernment. They are carried out alone or in association genetic heritage. All the FCCC have a molecular ge- with University Teaching Hospitals (Centres Hospita- netics platform for cancer to allow for the precise liers Universitaires, CHU): characterization of tumors and personalized mana- • 15 out of 24 geriatric oncology units. Integrated gement. patient • 6 out of 8 Centers for adolescents and young adults. • Individualized support for patients and those • 8 FCCC are coordinators for rare forms of cancer out of management: around them with, in particular, the development 17 healthcare establishments identified in France. • Screening of supportive care (including social support, diet, physical therapy, cosmetic care, psycho-oncology, • 2 trials out of 5 for the “personalized post-cancer • Early diagnosis sophrology, pain management, functional re-edu- program”. • Follow-up cation) and links with patient associations. • 6 out of 19 projects for proximity accommodation. after treatment • Patient/partner culture: patients are at the heart *In 2014 of the management and of the treatment choices it implies (patient committees, observatory of patient expectations). The expertise of the French The expertise of the french comprehensive cancer comprehensive cancer centers in terms of research centers in terms of teaching Along with healthcare and training, research is one of the fundamental mis- Since their creation, the French Comprehensive Cancer Centers (FCCC) have sions of the 20 French Comprehensive Cancer Centers (FCCC) that make up served a teaching mission in addition to their missions in healthcare and the UNICANCER Group. Research is carried out at the level of each Center as research focused on cancer. well as Group-wide, via R&D UNICANCER. UNICANCER provides on-going training in multi-disciplinary and transversal The historic role of the Centers in terms of research is to allow patients to benefit oncology through the European School for Training in Oncology (EFEC) from diagnostic and therapeutic innovations on the basis of all the disciplines and the training institutes at the Centers. involved in the management of cancer. In each Center, multi-disciplinary teams associate healthcare with research The originality of EFEC units in order to develop integrated cancer research. This is based on the fun- The EFEC was damental, translational and clinical research continuum. founded in 2002. It offers is to propose: structured teaching in the • several themes around the management of cancer context of on-going training. patients. Research in • Clinical research in the FCCC: – More than 250 clinical trials in progress sponsored by the FCCC. Its courses are open to all medical • a single training course for several professions, both the FCCC* – 18% of the patients in the FCCC are participating in a clinical trial (vs and paramedical professionals medical and paramedical. 8.5% for the national average according to the Register of the clinical trials in from the FCCC or other public • several organization modalities (courses both inside oncology by the French National Cancer Institut. or private establishments and outside the hospital). • Fundamental and translational research in human and social sciences: in par- working in the field ticular through more than 70 partnerships with public research organiza- of oncology in France Every year, EFEC: tions (the French National Institute for Health and Medical Research/INSERM, or abroad. • trains more than 1,500 professionals. the French National Center for Scientific Research/CNRS, and universities). • provides more than 90 training sessions. • With 9,715 publications in 5 years, the FCCC teams contribute to more www.efec.eu than 27% of French bibliographic production in the field of cancer (excluding publications in Social Sciences and in French only). *(figures for 2013) Training The FCCC propose: + 160 in the • Continuous Professional Development (DPC) programs. French and • Higher education programs for doctors and specialists in the disciplines R&D UNICANCER + 60 international healthcare Centers of oncology (different diplomas proposed, such as Masters Degrees etc.). clinical trials in establishments • Paramedical training (nurses, electro-radiology technicians, medical in figures progress participate in the assistants, etc.). R&D UNICANCER, UNICANCER’s scientific recruitment of department, is the number 1 operator patients in academic clinical research Every year, the FCCC: in oncology in France. • Welcome more than 200 interns. It hosts the French liaison office of the • Propose more than 240 on-going training oncology. European Organisation for Research and + 4 400 Treatment of Cancer (EORTC). patients included (Data for 21/12/2013) UNICANCER anticipates and invents the oncology of the future The characterization of tumors, making The ambition of the Group of French Comprehensive Cancer Centers is to always stay one step ahead so as to be able to innovate together on behalf it possible to better understand them in of patients. order to better treat them In the study, “UNICANCER: Changes in cancer care by 2020”, the French Com- The French Comprehensive Cancer Centers are currently developing the prehensive Cancer Centers identified and defined the main areas of pro- practice of biological and genetic cancer diagnosis, both at the level of the gress to be made in management in oncology by 2020: individual and of the tumor. They are all part of one of the 28 hospital plat- forms for the molecular genetics of cancer supported by the French National Cancer Institute. An increase in out-patient surgery all the Centers have an out-patient surgery program. According to the UNI- CANCER study, this should represent half of breast cancer surgery by 2020. The development of interventional radiology which uses imaging techniques for more precise and less invasive acts for Radiotherapy will be more targeted patients. Eleven Centers already perform acts of interventional radiology for and less invasive diagnostic and therapeutic purposes. The UNICANCER study shows that the number of hospitalizations for acts of interventional radiology could be mul- This is at the heart of the current trend for de-escalation in the treatment tiplied by 4 in the years to come. of cancer, thanks to techniques with better performances. This change is already underway in the French Comprehensive Cancer Centers, which ma- nage almost 25% of all radiotherapy sessions in France. The development of supportive care for the overall management of patients during and after their illness. The The development of oral treatments French Comprehensive Cancer Centers pioneered the creation of supportive care departments. These departments offer patients and those around them and home hospitalization personalized back-up, thanks to consultations with nutritionists, psycholo- gists, socio-beauty therapists, social workers and specialists in palliative care. chemotherapy For the French Comprehensive Cancer Centers, support care is an inseparable By 2020, the proportion of medical treatments administered orally could in- part of quality patient management. According to UNICANCER study, the crease from today’s 25% to 50%, and intravenous chemotherapy decrease workforce dedicated to supportive care in the FCCC will double by 2020. by 25%. The FCCC have implemented a wide range of actions to accompany this progress: home hospitalization units, specific consultations, therapy education programs, etc. Arabie Souadite 1 picto gens L’expertise des Centres de lutte contre The expertise of the French Liban : 1 picto gens Emirats Arabes Unis : 1 picto maison le cancer s’exporte à l’international Comprehensive Cancer Centers abroad Bahreïn 1 picto maison Koweït 1 picto maison Les Centres de lutte contre le cancer ont développé de nombreuses collaborations avec les pays The French Comprehensive Cancer Centers (FCCC) have developed a number of collaborations Liban : 1 gens du monde entier. Cela comprend des formations de professionnels de santé, des partenariats with countries all over the world. This includes initial universitary and on-going expert training for scientifiques mais également l’accompagnement à l’ouverture de services et de centres de healthcare professionals, scientific partnerships, as well as support for opening oncology ISRAEL : 1 maison et 1 gens cancérologie sur place, inspirés du modèle des Centres de lutte contre le cancer. services and centers based on the FCCC model. Syrie : 1 gens Moyen Orient : 1 gens

Roumanie: 1 miscroscope République tchèque, 1 maison Hongrie, 1 maison Slovaquie, 1 maison Kazakhstan : 1 picto maison et 1 picto gens Nord Soudan : 1 picto gens Vietnam : 1 gens CAMBODGE = 1 picto maison et 1 picto gens Italie : 3 pictos gens et 1 picto microscope 1 maison Canada : 2 pictos maison et 2 pictos gens 1 picto microscope Costa Rica 1 gens Uruguay : 1 gens Chine : 3 maisons et 1 gens Russie : 1 gens 1 microscope RUSSIE 1 picto maison et 1 picto gens Japon : 1 maison BURKINA FASO = 1 picto gens RWANDA 1 picto gens Côte d’Ivoire : 2 pictos maison et 1 picto gens Sénégal : 1 picto gens Tunisie : 1 gens et 1 miroscope Algérie 1 picto maison et 1 picto gens 1 picto microscope Collaborations médicales, création de services et Maroc : 4 picto gens de centres en cancérologie Chili : 3 gens 1 microscope Medical collaborations, settlement of services and oncology centers Allemagne, 1 maison et 1 picto microscope Suisse : 1 gens Partenariats et programmes de recherche communs Belgique : 1 maison 1 miroscope entre établissements Angleterre, 1 maison Inter-establishment partnerships and joint Finlande, 1 maison research projects Pays-Bas, 1 maison Danemark 1 maison Formations et échanges de professionnels de santé Espagne : 1 Gens Training and exchange for healthcare professionals Groupe des Centres de lutte contre le cancer