Regulation of miRNA expression by rifampin in human hepatocytes

Anuradha Ramamoorthy, Yunlong Liu, Santosh Philips, Zeruesenay Desta, Hai Lin, Chirayu Goswami, Andrea Gaedigk, Lang Li, David A. Flockhart, and Todd C. Skaar

Drug Metabolism and Disposition

Supplemental Table 4. Correlations of miRNA and predicted CYP mRNA expression. miRNA Target R p-value hsa-miR-200b CYP1B1 -0.944 0.001 hsa-miR-15b CYP2U1 -0.861 0.013 hsa-miR-19a CYP4F11 0.854 0.014 hsa-miR-15b CYP1B1 -0.836 0.019 hsa-miR-429 CYP1B1 -0.812 0.026 hsa-miR-590-5p CYP2B7P1 0.807 0.028 hsa-miR-221 CYP1B1 -0.772 0.042 hsa-miR-200b CYP4V2 -0.769 0.043 hsa-miR-25 CYP4X1 0.746 0.054 hsa-miR-195 CYP4V2 -0.715 0.071 hsa-miR-182 CYP8B1 0.703 0.078 hsa-miR-590-5p CYP2B6 0.691 0.086 hsa-miR-148a CYP2B7P1 0.668 0.101 hsa-miR-34a CYP11A1 -0.662 0.105 hsa-miR-15b CYP4V2 -0.655 0.110 hsa-miR-106b CYP39A1 0.647 0.116 hsa-miR-20a CYP4V2 -0.645 0.118 hsa-miR-200a CYP4V2 -0.643 0.120 hsa-miR-200a CYP3A43 0.639 0.122 hsa-miR-27a CYP4F2 0.630 0.130 hsa-miR-182 CYP2B7P1 -0.611 0.145 hsa-miR-21 CYP2J2 -0.608 0.147 hsa-miR-125b CYP4X1 0.607 0.149 hsa-miR-26b CYP4V2 -0.597 0.157 hsa-miR-125b CYP4V2 -0.588 0.165 hsa-miR-340 CYP4V2 -0.584 0.169 hsa-miR-200a CYP4F3 0.565 0.187 hsa-miR-148a CYP2B6 0.557 0.194 hsa-miR-340 CYP4A22 0.546 0.205 hsa-miR-429 CYP4V2 -0.543 0.208 hsa-miR-30d CYP1B1 -0.542 0.209 hsa-miR-29b CYP2B6 0.538 0.213 hsa-miR-145 CYP4F12 -0.533 0.218 hsa-miR-362-3p CYP2B7P1 0.530 0.221 hsa-miR-145 CYP2C18 0.530 0.221 hsa-miR-27a CYP3A4 0.529 0.222 hsa-miR-195 CYP1B1 -0.528 0.223 hsa-miR-221 CYP7A1 -0.519 0.233 hsa-miR-132 CYP4X1 0.518 0.234 hsa-miR-362-3p CYP2R1 -0.516 0.236 hsa-miR-340 CYP2U1 -0.511 0.241 hsa-miR-29b CYP2B7P1 0.500 0.253 hsa-miR-135a CYP1B1 0.500 0.254 hsa-miR-362-3p CYP51A1 -0.497 0.256 hsa-miR-135a CYP4F2 0.496 0.258 hsa-miR-203 CYP1A2 -0.494 0.260 hsa-miR-590-5p CYP2U1 -0.482 0.273 hsa-miR-203 CYP7A1 0.480 0.276 hsa-miR-200a CYP4F2 0.477 0.279 hsa-miR-20a CYP7B1 -0.473 0.283 hsa-miR-106b CYP4V2 -0.467 0.290 hsa-miR-99b CYP1B1 -0.456 0.304 hsa-miR-106b CYP4F3 0.454 0.306 hsa-miR-335 CYP1B1 -0.449 0.312 hsa-miR-505 CYP7A1 0.443 0.320 hsa-miR-145 CYP7A1 -0.430 0.336 hsa-miR-145 CYP3A43 -0.426 0.341 hsa-miR-145 CYP7B1 -0.424 0.343 hsa-miR-203 CYP4A22 0.412 0.358 hsa-miR-106b CYP3A4 0.407 0.365 hsa-miR-135a CYP4V2 0.407 0.365 hsa-miR-26b CYP4F12 0.397 0.378 hsa-miR-203 CYP4F12 0.395 0.380 hsa-miR-27a CYP2C18 0.382 0.398 hsa-miR-125b CYP7A1 0.371 0.412 hsa-miR-182 CYP1A2 0.369 0.415 hsa-miR-340 CYP4F12 0.368 0.416 hsa-miR-106b CYP7B1 -0.368 0.417 hsa-miR-20a CYP2U1 0.363 0.423 hsa-miR-20a CYP3A5 0.361 0.426 hsa-miR-362-3p CYP4X1 0.359 0.429 hsa-miR-200a CYP2B6 0.353 0.438 hsa-miR-340 CYP4A11 0.349 0.443 hsa-miR-145 CYP4A11 0.349 0.443 hsa-miR-21 CYP2B6 0.346 0.447 hsa-miR-429 CYP7A1 -0.332 0.466 hsa-miR-335 CYP2A13 0.330 0.470 hsa-miR-200a CYP2C8 0.296 0.519 hsa-miR-340 CYP8B1 -0.295 0.521 hsa-miR-20a CYP1A2 0.290 0.529 hsa-miR-429 CYP3A43 -0.276 0.550 hsa-miR-149 CYP1A1 0.271 0.556 hsa-miR-203 CYP8B1 -0.265 0.565 hsa-miR-25 CYP2C8 -0.263 0.569 hsa-miR-106b CYP2U1 0.263 0.569 hsa-miR-19a CYP2U1 -0.254 0.582 hsa-miR-15b CYP2J2 0.254 0.583 hsa-miR-106b CYP4F2 0.252 0.586 hsa-miR-30d CYP4V2 -0.248 0.592 hsa-miR-590-5p CYP3A5 -0.246 0.595 hsa-miR-21 CYP3A7 -0.245 0.597 hsa-miR-340 CYP3A4 0.243 0.599 hsa-miR-135a CYP3A43 0.240 0.604 hsa-miR-29b CYP4V2 0.235 0.612 hsa-miR-27a CYP4F3 -0.235 0.612 hsa-miR-20a CYP39A1 0.233 0.616 hsa-miR-21 CYP3A5 0.228 0.623 hsa-miR-335 CYP51A1 -0.220 0.635 hsa-miR-182 CYP4V2 0.218 0.639 hsa-miR-203 CYP4V2 -0.209 0.653 hsa-miR-200b CYP2E1 0.209 0.654 hsa-miR-148a CYP3A5 0.205 0.660 hsa-miR-194 CYP4V2 -0.201 0.665 hsa-miR-335 CYP7A1 0.194 0.676 hsa-miR-340 CYP7A1 -0.194 0.677 hsa-miR-218 CYP2C18 -0.179 0.701 hsa-miR-362-3p CYP4A11 0.160 0.732 hsa-miR-132 CYP3A43 0.152 0.744 hsa-miR-20a CYP4F2 -0.143 0.760 hsa-miR-106b CYP3A5 -0.142 0.761 hsa-miR-149 CYP4F11 -0.137 0.769 hsa-miR-340 CYP39A1 -0.136 0.771 hsa-miR-135a CYP4A22 -0.125 0.790 hsa-miR-29c CYP2B7P1 0.123 0.793 hsa-miR-30d CYP3A5 -0.120 0.799 hsa-miR-590-5p CYP3A7 0.118 0.801 hsa-miR-221 CYP4X1 0.115 0.807 hsa-miR-20a CYP4F3 0.114 0.808 hsa-miR-9 CYP4X1 0.113 0.810 hsa-miR-34a CYP2D7P1 0.111 0.813 hsa-miR-203 CYP3A7 0.109 0.817 hsa-miR-203 CYP3A7 0.109 0.817 hsa-miR-132 CYP4F3 0.108 0.818 hsa-miR-132 CYP2U1 -0.107 0.820 hsa-miR-200b CYP3A43 0.101 0.829 hsa-miR-200b CYP3A43 0.101 0.829 hsa-miR-200b CYP3A43 0.101 0.829 hsa-miR-34a CYP3A5 0.098 0.834 hsa-miR-194 CYP7B1 -0.098 0.835 hsa-miR-200b CYP7A1 0.098 0.835 hsa-miR-27a CYP39A1 -0.089 0.849 hsa-miR-340 CYP3A7 -0.087 0.853 hsa-miR-19a CYP2E1 0.086 0.855 hsa-miR-505 CYP4A22 -0.082 0.861 hsa-miR-21 CYP3A43 -0.079 0.866 hsa-miR-195 CYP2C8 0.079 0.867 hsa-miR-340 CYP2C18 -0.069 0.883 hsa-miR-429 CYP2E1 0.063 0.893 hsa-miR-505 CYP4F11 -0.063 0.893 hsa-miR-29b CYP3A5 -0.047 0.920 hsa-miR-25 CYP2B6 0.044 0.926 hsa-miR-218 CYP51A1 -0.037 0.937 hsa-miR-30d CYP2U1 -0.036 0.939 hsa-miR-182 CYP1B1 -0.022 0.962 hsa-miR-195 CYP2C18 -0.018 0.970 hsa-miR-182 CYP51A1 0.014 0.976 hsa-miR-20a CYP3A4 0.011 0.982 hsa-miR-29c CYP2B6 0.010 0.983 hsa-miR-362-3p CYP4A22 0.005 0.991