Supplementary data S1 A. Transcripts used for the calculation of the mean centroid values for mitochondrial ribosomal protein small subunits probe ID gene symbol gene description 1 7818_at DAP3/MRPS29 death associated protein 3 2 55173_at MRPS10 mitochondrial ribosomal protein S10 3 64963_at MRPS11 mitochondrial ribosomal protein S11 4 6183_at MRPS12 mitochondrial ribosomal protein S12 5 63931_at MRPS14 mitochondrial ribosomal protein S14 6 64960_at MRPS15 mitochondrial ribosomal protein S15 7 51021_at MRPS16 mitochondrial ribosomal protein S16 8 51373_at MRPS17 mitochondrial ribosomal protein S17 9 55168_at MRPS18A mitochondrial ribosomal protein S18A 10 28973_at MRPS18B mitochondrial ribosomal protein S18B 11 51023_at MRPS18C mitochondrial ribosomal protein S18C 12 51116_at MRPS2 mitochondrial ribosomal protein S2 13 54460_at MRPS21 mitochondrial ribosomal protein S21 14 56945_at MRPS22 mitochondrial ribosomal protein S22 15 51649_at MRPS23 mitochondrial ribosomal protein S23 16 64432_at MRPS25 mitochondrial ribosomal protein S25 17 64949_at MRPS26 mitochondrial ribosomal protein S26 18 23107_at MRPS27 mitochondrial ribosomal protein S27 19 28957_at MRPS28 mitochondrial ribosomal protein S28 20 10884_at MRPS30 mitochondrial ribosomal protein S30 21 10240_at MRPS31 mitochondrial ribosomal protein S31 22 51650_at MRPS33 mitochondrial ribosomal protein S33 23 65993_at MRPS34 mitochondrial ribosomal protein S34 24 60488_at MRPS35 mitochondrial ribosomal protein S35 25 92259_at MRPS36 mitochondrial ribosomal protein S36 26 64969_at MRPS5 mitochondrial ribosomal protein S5 27 51081_at MRPS7 mitochondrial ribosomal protein S7 28 64965_at MRPS9 mitochondrial ribosomal protein S9 29 55665_at URGCP/MRPS24 upregulator of cell proliferation

B. Transcripts used for the calculation of the mean centroid values for mitochondrial ribosomal protein large subunits probe ID gene symbol gene description 1 10573_at MRPL28 mitochondrial ribosomal protein L28 2 11222_at MRPL3 mitochondrial ribosomal protein L3 3 114294_at LACTB/MRPL56 lactamase, beta 4 116540_at MRPL53 mitochondrial ribosomal protein L53 5 116541_at MRPL54 mitochondrial ribosomal protein L54 6 122704_at MRPL52 mitochondrial ribosomal protein L52 7 124995_at MRPL10 mitochondrial ribosomal protein L10 8 128308_at MRPL55 mitochondrial ribosomal protein L55 9 219927_at MRPL21 mitochondrial ribosomal protein L21 10 26589_at MRPL46 mitochondrial ribosomal protein L46 11 28977_at MRPL42 mitochondrial ribosomal protein L42 12 28998_at MRPL13 mitochondrial ribosomal protein L13 13 29074_at MRPL18 mitochondrial ribosomal protein L18 14 29088_at MRPL15 mitochondrial ribosomal protein L15 15 29093_at MRPL22 mitochondrial ribosomal protein L22 16 51069_at MRPL2 mitochondrial ribosomal protein L2 17 51073_at MRPL4 mitochondrial ribosomal protein L4 18 51253_at MRPL37 mitochondrial ribosomal protein L37 19 51258_at MRPL51 mitochondrial ribosomal protein L51 20 51263_at MRPL30 mitochondrial ribosomal protein L30 21 51264_at MRPL27 mitochondrial ribosomal protein L27 22 51318_at MRPL35 mitochondrial ribosomal protein L35 23 51642_at MRPL48 mitochondrial ribosomal protein L48 24 54148_at MRPL39 mitochondrial ribosomal protein L39 25 54534_at MRPL50 mitochondrial ribosomal protein L50 26 54948_at MRPL16 mitochondrial ribosomal protein L16 27 55052_at MRPL20 mitochondrial ribosomal protein L20 28 57129_at MRPL47 mitochondrial ribosomal protein L47 29 6150_at MRPL23 mitochondrial ribosomal protein L23 30 6182_at MRPL12 mitochondrial ribosomal protein L12 31 63875_at MRPL17 mitochondrial ribosomal protein L17 32 64928_at MRPL14 mitochondrial ribosomal protein L14 33 64975_at MRPL41 mitochondrial ribosomal protein L41 34 64976_at MRPL40 mitochondrial ribosomal protein L40 35 64978_at MRPL38 mitochondrial ribosomal protein L38 36 64979_at MRPL36 mitochondrial ribosomal protein L36 37 64981_at MRPL34 mitochondrial ribosomal protein L34 38 64983_at MRPL32 mitochondrial ribosomal protein L32 39 65003_at MRPL11 mitochondrial ribosomal protein L11 40 65005_at MRPL9 mitochondrial ribosomal protein L9 41 65008_at MRPL1 mitochondrial ribosomal protein L1 42 65080_at MRPL44 mitochondrial ribosomal protein L44 43 740_at MRPL49 mitochondrial ribosomal protein L49 44 78988_at MRPL57 mitochondrial ribosomal protein L57 45 79590_at MRPL24 mitochondrial ribosomal protein L24 46 84311_at MRPL45 mitochondrial ribosomal protein L45 47 84545_at MRPL43 mitochondrial ribosomal protein L43 48 9553_at MRPL33 mitochondrial ribosomal protein L33 49 9801_at MRPL19 mitochondrial ribosomal protein L19 Supplementary data S2A Adipocytes - significantly differentially expressed genes in the heavier compared with their leaner co-twins Num Gene ID Gene Gene name logFC Average P-value Adjusted p- ber symbol Expression value

1 8797 TNFRSF10 tumor necrosis factor 0,59083309 4,427019 2,88E-07 0,0056353 A receptor superfamily, member 10a

2 389136 VGLL3 vestigial-like family 0,58675054 9,9454663 1,86E-06 0,01822283 member 3 3 280636 C11orf31 chromosome 11 open -0,1478251 10,506952 3,62E-06 0,02360774 reading frame 31

4 55824 PAG1 phosphoprotein 0,4970699 3,7551245 5,03E-06 0,02460058 associated with glycosphingolipid microdomains 1 5 100132891 LOC10013 uncharacterized 0,77727904 7,7149693 8,67E-06 0,02634379 2891 LOC100132891 6 10632 ATP5L ATP synthase, H+ -0,1336639 11,013875 9,25E-06 0,02634379 transporting, mitochondrial Fo complex, subunit G 7 1152 CKB creatine kinase, brain -0,5444203 11,68217 9,44E-06 0,02634379

8 94103 ORMDL3 ORM1-like 3 (S. -0,6840423 8,1706617 1,47E-05 0,03593973 cerevisiae) 9 5164 PDK2 pyruvate -0,5510062 8,0149076 1,97E-05 0,03935069 dehydrogenase kinase, isozyme 2 10 7262 PHLDA2 pleckstrin homology- 1,07652785 7,8242104 2,12E-05 0,03935069 like domain, family A, member 2

11 84641 HIATL1 hippocampus 0,20167354 9,9931203 2,33E-05 0,03935069 abundant transcript- like 1 12 3685 ITGAV integrin, alpha V 0,40560256 12,505164 2,48E-05 0,03935069 13 55909 BIN3 bridging integrator 3 -0,3025806 7,5255894 2,62E-05 0,03935069

14 59338 PLEKHA1 pleckstrin homology 0,30080482 8,0741468 3,14E-05 0,04389707 domain containing, family A (phosphoinositide binding specific) member 1 15 11259 FILIP1L filamin A interacting 0,44439536 9,2811164 3,42E-05 0,04459114 protein 1-like

16 55876 GSDMB gasdermin B -0,8282223 5,4841578 4,65E-05 0,04837027 17 79611 ACSS3 acyl-CoA synthetase -0,4982143 9,8117855 4,67E-05 0,04837027 short-chain family member 3 18 4714 NDUFB8 NADH dehydrogenase -0,162635 8,1121535 4,70E-05 0,04837027 (ubiquinone) 1 beta subcomplex, 8, 19kDa

19 283635 FAM177A1 family with sequence 0,35627743 9,8510044 4,70E-05 0,04837027 similarity 177, member A1 20 10840 ALDH1L1 aldehyde -0,7048492 8,9671951 5,35E-05 0,05227571 dehydrogenase 1 family, member L1 21 57698 KIAA1598 KIAA1598 0,60182131 8,5613326 6,39E-05 0,05414216 22 7296 TXNRD1 thioredoxin reductase 0,37511252 9,251955 6,45E-05 0,05414216 1 23 10243 GPHN gephyrin -0,6818428 7,439626 6,99E-05 0,05414216 24 8935 SKAP2 src kinase associated 0,23941068 9,6205907 7,20E-05 0,05414216 phosphoprotein 2

25 10240 MRPS31 mitochondrial -0,2529732 8,9346526 7,37E-05 0,05414216 ribosomal protein S31

26 9 NAT1 N-acetyltransferase 1 0,64360534 6,0255128 7,39E-05 0,05414216 (arylamine N- acetyltransferase) 27 6282 S100A11 S100 calcium binding 0,33119858 12,827772 7,48E-05 0,05414216 protein A11 28 2752 GLUL glutamate-ammonia -0,6937216 12,912153 8,01E-05 0,05546594 ligase 29 1457 CSNK2A1 casein kinase 2, alpha -0,2450385 8,1054354 8,36E-05 0,05546594 1 polypeptide 30 348094 ANKDD1A ankyrin repeat and 0,84910611 7,4564264 8,68E-05 0,05546594 death domain containing 1A 31 51082 POLR1D polymerase (RNA) I -0,2131739 9,7414882 8,80E-05 0,05546594 polypeptide D, 16kDa

32 8076 MFAP5 microfibrillar 1,08585902 10,410541 9,30E-05 0,05679216 associated protein 5 33 761 CA3 carbonic anhydrase III, -1,6893744 9,7492993 0,0001057 0,05714132 muscle specific 34 10003 NAALAD2 N-acetylated alpha- -1,205879 6,983475 0,0001094 0,05714132 linked acidic dipeptidase 2 35 975 CD81 CD81 molecule -0,1519673 14,339619 0,0001127 0,05714132 36 10765 KDM5B lysine (K)-specific -0,2568028 7,3558588 0,000113 0,05714132 demethylase 5B 37 4982 TNFRSF11 tumor necrosis factor 0,95214347 5,1118641 0,0001146 0,05714132 B receptor superfamily, member 11b

38 11129 CLASRP CLK4-associating -0,3679496 7,7283855 0,0001193 0,05714132 serine/arginine rich protein 39 4131 MAP1B microtubule- 0,65152409 9,8785557 0,0001199 0,05714132 associated protein 1B

40 2098 ESD esterase D -0,1728897 12,493304 0,0001225 0,05714132 41 378 ARF4 ADP-ribosylation 0,20714477 12,861264 0,0001253 0,05714132 factor 4 42 6840 SVIL supervillin -0,6064509 9,6770116 0,0001278 0,05714132 43 64785 GINS3 GINS complex subunit -0,7494822 6,2534575 0,0001303 0,05714132 3 (Psf3 homolog)

44 8660 IRS2 insulin receptor -0,390901 12,534615 0,0001315 0,05714132 substrate 2 45 125144 LRRC75A- LRRC75A antisense -0,1773154 3,6128824 0,0001316 0,05714132 AS1 RNA 1 46 5372 PMM1 phosphomannomutase -0,5994771 8,006015 0,0001394 0,05920945 1 47 51503 CWC15 CWC15 spliceosome- -0,1806524 10,341191 0,0001549 0,06075468 associated protein homolog (S. cerevisiae)

48 55268 ECHDC2 enoyl CoA hydratase -0,4100012 10,038157 0,000155 0,06075468 domain containing 2

49 57103 C12orf5 chromosome 12 open 0,56741348 7,2666161 0,0001562 0,06075468 reading frame 5

50 124995 MRPL10 mitochondrial -0,2553225 9,7662062 0,0001564 0,06075468 ribosomal protein L10

51 3839 KPNA3 karyopherin alpha 3 0,24915677 9,0409151 0,0001591 0,06075468 (importin alpha 4) 52 408 ARRB1 arrestin, beta 1 -0,2743682 7,421236 0,0001622 0,06075468 53 23012 STK38L serine/threonine 0,44623359 8,4084615 0,0001677 0,06075468 kinase 38 like 54 1836 SLC26A2 solute carrier family 26 0,32641813 6,6823865 0,0001745 0,06075468 (anion exchanger), member 2

55 3033 HADH hydroxyacyl-CoA -0,3152788 12,410701 0,0001769 0,06075468 dehydrogenase 56 1154 CISH cytokine inducible SH2- -1,5050601 8,5017779 0,0001819 0,06075468 containing protein

57 6902 TBCA tubulin folding -0,1541321 13,255602 0,0001827 0,06075468 cofactor A 58 83608 C18orf21 chromosome 18 open -0,3942047 8,0982665 0,0001836 0,06075468 reading frame 21

59 1460 CSNK2B casein kinase 2, beta -0,2426553 10,650804 0,0001888 0,06075468 polypeptide 60 22949 PTGR1 prostaglandin -0,1713209 11,233624 0,0001892 0,06075468 reductase 1 61 80763 C12orf39 chromosome 12 open -1,8311733 5,3824827 0,0001913 0,06075468 reading frame 39

62 219348 PLAC9 placenta-specific 9 0,63283863 11,487044 0,0001927 0,06075468 63 51116 MRPS2 mitochondrial -0,4094129 7,831184 0,0001978 0,06086622 ribosomal protein S2

64 55619 DOCK10 dedicator of 0,75170119 4,3238649 0,0001993 0,06086622 cytokinesis 10 65 23176 SEPT8 septin 8 0,35966453 6,8090098 0,0002049 0,06087653 66 563 AZGP1 alpha-2-glycoprotein 1, -1,2762497 9,3741934 0,0002061 0,06087653 zinc-binding

67 192668 CYS1 cystin 1 0,37937093 3,9133353 0,0002087 0,06087653 68 5862 RAB2A RAB2A, member RAS 0,18390995 10,578691 0,0002231 0,0621951 oncogene family

69 347733 TUBB2B tubulin, beta 2B class 1,12152839 5,5742711 0,0002244 0,0621951 IIb 70 5311 PKD2 polycystic kidney 0,33604643 10,651466 0,0002261 0,0621951 disease 2 (autosomal dominant)

71 219736 STOX1 storkhead box 1 -0,9472811 7,979353 0,0002343 0,0621951 72 6730 SRP68 signal recognition -0,1878146 9,4746938 0,0002362 0,0621951 particle 68kDa 73 10827 FAM114A2 family with sequence 0,17286388 7,9703937 0,0002398 0,0621951 similarity 114, member A2 74 57104 PNPLA2 patatin-like -0,2713634 9,9423058 0,0002423 0,0621951 phospholipase domain containing 2 75 2517 FUCA1 fucosidase, alpha-L- 1, 0,33142209 8,675421 0,0002426 0,0621951 tissue 76 1652 DDT D-dopachrome -0,2915201 11,510138 0,0002443 0,0621951 tautomerase 77 10131 TRAP1 TNF receptor- -0,2764948 7,6364816 0,0002466 0,0621951 associated protein 1 78 328 APEX1 APEX nuclease -0,1687819 11,031158 0,0002482 0,0621951 (multifunctional DNA repair enzyme) 1

79 1031 CDKN2C cyclin-dependent -0,4918593 12,48428 0,0002551 0,06312086 kinase inhibitor 2C (p18, inhibits CDK4) 80 23022 PALLD palladin, cytoskeletal 0,70913547 10,154519 0,0002784 0,06586415 associated protein

81 637 BID BH3 interacting 0,28692267 6,6345624 0,0002794 0,06586415 domain death agonist

82 90507 SCRN2 secernin 2 -0,3363803 8,4360933 0,0002805 0,06586415 83 1743 DLST dihydrolipoamide S- -0,2908549 10,140398 0,0002817 0,06586415 succinyltransferase (E2 component of 2-oxo- glutarate complex)

84 9473 THEMIS2 thymocyte selection 0,46045816 4,1944728 0,0002831 0,06586415 associated family member 2 85 57181 SLC39A10 solute carrier family 39 0,37937306 8,5954372 0,0003075 0,07069583 (zinc transporter), member 10

86 64747 MFSD1 major facilitator 0,31579727 10,790709 0,0003174 0,0714559 superfamily domain containing 1 87 666 BOK BCL2-related ovarian -0,5290504 11,030834 0,0003196 0,0714559 killer 88 5306 PITPNA phosphatidylinositol 0,17796895 8,0302858 0,0003217 0,0714559 transfer protein, alpha

89 1149 CIDEA cell death-inducing -0,9442942 11,408959 0,000328 0,0715039 DFFA-like effector a 90 55740 ENAH enabled homolog 0,24548606 6,9344948 0,0003293 0,0715039 (Drosophila) 91 8560 DEGS1 delta(4)-desaturase, 0,1715939 11,207332 0,0003373 0,07244733 sphingolipid 1

92 55168 MRPS18A mitochondrial -0,2785625 7,5861943 0,0003536 0,07348655 ribosomal protein S18A 93 9556 C14orf2 chromosome 14 open -0,1713488 9,9620787 0,0003566 0,07348655 reading frame 2

94 439921 MXRA7 matrix-remodelling 0,35433334 7,0340943 0,0003597 0,07348655 associated 7 95 9926 LPGAT1 lysophosphatidylglycer 0,39622485 9,7528226 0,0003607 0,07348655 ol acyltransferase 1

96 23240 KIAA0922 KIAA0922 -0,4087519 7,744602 0,000364 0,07348655 97 1548 CYP2A6 cytochrome P450, -0,2199444 6,1599059 0,0003674 0,07348655 family 2, subfamily A, polypeptide 6 98 79746 ECHDC3 enoyl CoA hydratase -0,6322987 11,422149 0,0003685 0,07348655 domain containing 3

99 6357 CCL13 chemokine (C-C motif) 1,29437375 4,6307173 0,0003775 0,07391217 ligand 13 100 6224 RPS20 ribosomal protein S20 -0,151013 13,026726 0,0003846 0,07391217

101 4176 MCM7 minichromosome -0,1427487 8,2011971 0,0003915 0,07391217 maintenance complex component 7

102 201895 SMIM14 small integral 0,2839003 9,4028053 0,0003942 0,07391217 membrane protein 14

103 26589 MRPL46 mitochondrial -0,2190106 8,4411412 0,000397 0,07391217 ribosomal protein L46

104 6774 STAT3 signal transducer and 0,19678052 10,449878 0,0003995 0,07391217 activator of transcription 3 (acute- phase response factor)

105 1153 CIRBP cold inducible RNA -0,1991778 7,9559277 0,0004005 0,07391217 binding protein 106 51129 ANGPTL4 angiopoietin-like 4 -0,4656969 10,67416 0,0004009 0,07391217 107 586 BCAT1 branched chain amino- 0,69939265 4,6940957 0,0004088 0,07420543 acid transaminase 1, cytosolic

108 55793 FAM63A family with sequence -0,7612932 5,8137138 0,0004133 0,07420543 similarity 63, member A 109 9242 MSC musculin 0,63884695 3,3814906 0,0004139 0,07420543 110 9249 DHRS3 dehydrogenase/reduct -0,4748273 11,499808 0,0004201 0,0746332 ase (SDR family) member 3 111 2123 EVI2A ecotropic viral 1,46107717 4,7658782 0,0004291 0,07477964 integration site 2A 112 9180 OSMR oncostatin M receptor 0,4195898 5,5484353 0,0004304 0,07477964

113 5604 MAP2K1 mitogen-activated 0,28321854 11,780287 0,0004334 0,07477964 protein kinase kinase 1 114 10092 ARPC5 actin related protein 0,32517164 9,596745 0,0004362 0,07477964 2/3 complex, subunit 5, 16kDa

115 29087 THYN1 thymocyte nuclear -0,3532261 9,6899169 0,0004429 0,07527752 protein 1 116 2162 F13A1 coagulation factor XIII, 1,24217312 9,2813999 0,0004551 0,07658685 A1 polypeptide 117 54977 SLC25A38 solute carrier family -0,3375278 7,7689548 0,0004676 0,07658685 25, member 38 118 85004 RERG RAS-like, estrogen- 0,4398484 7,8267374 0,0004696 0,07658685 regulated, growth inhibitor 119 8667 EIF3H eukaryotic translation -0,2502525 11,951763 0,0004721 0,07658685 initiation factor 3, subunit H

120 310 ANXA7 annexin A7 0,16110094 11,934372 0,0004729 0,07658685 121 5341 PLEK pleckstrin 0,93388737 6,2089059 0,0004742 0,07658685 122 665 BNIP3L BCL2/adenovirus E1B -0,225049 13,328138 0,0004851 0,07728388 19kDa interacting protein 3-like

123 5827 PXMP2 peroxisomal -0,5061259 8,4096 0,0004864 0,07728388 membrane protein 2, 22kDa 124 140809 SRXN1 sulfiredoxin 1 0,30769696 5,8396019 0,0004952 0,07732331 125 2054 STX2 syntaxin 2 0,32137589 7,3177997 0,0004968 0,07732331 126 201161 CENPV centromere protein V -0,4820433 6,3875317 0,0005016 0,07732331

127 7342 UBP1 upstream binding 0,30103736 9,6984629 0,0005025 0,07732331 protein 1 (LBP-1a) 128 11001 SLC27A2 solute carrier family 27 -1,9808814 3,762114 0,0005259 0,07888426 (fatty acid transporter), member 2 129 728 C5AR1 complement 1,14861933 6,1195459 0,000533 0,07888426 component 5a receptor 1 130 92126 DSEL dermatan sulfate 0,38249827 5,5998755 0,0005338 0,07888426 epimerase-like 131 81631 MAP1LC3B microtubule- -0,1163717 11,432162 0,0005358 0,07888426 associated protein 1 light chain 3 beta 132 54749 EPDR1 ependymin related 1 0,50809895 10,694196 0,0005408 0,07888426

133 83439 TCF7L1 transcription factor 7- -0,3564506 8,4334715 0,0005585 0,07888426 like 1 (T-cell specific, HMG-box) 134 23213 SULF1 sulfatase 1 -0,7229806 6,3692188 0,0005609 0,07888426 135 79656 BEND5 BEN domain -0,3187147 5,299047 0,0005639 0,07888426 containing 5 136 51205 ACP6 acid phosphatase 6, -0,451512 6,6608661 0,0005669 0,07888426 lysophosphatidic 137 23603 CORO1C coronin, actin binding 0,35538441 11,389982 0,0005755 0,07888426 protein, 1C 138 6275 S100A4 S100 calcium binding 0,62492552 13,920092 0,0005764 0,07888426 protein A4 139 3290 HSD11B1 hydroxysteroid (11- 0,89140549 9,9009594 0,0005811 0,07888426 beta) dehydrogenase 1

140 25875 LETMD1 LETM1 domain -0,3729494 10,119124 0,0005835 0,07888426 containing 1 141 5638 PRRG1 proline rich Gla (G- 0,30541965 9,156591 0,0005856 0,07888426 carboxyglutamic acid) 1 142 11331 PHB2 prohibitin 2 -0,2625253 12,077478 0,0005897 0,07888426 143 64061 TSPYL2 TSPY-like 2 -0,4410985 6,04024 0,000591 0,07888426 144 338 APOB apolipoprotein B -0,5696929 5,5638142 0,0005951 0,07888426 145 23604 DAPK2 death-associated -0,6593306 7,8697778 0,0005969 0,07888426 protein kinase 2 146 4329 ALDH6A1 aldehyde -0,542832 9,7088825 0,0005993 0,07888426 dehydrogenase 6 family, member A1 147 113612 CYP2U1 cytochrome P450, 0,15408369 6,5502861 0,0006092 0,07888426 family 2, subfamily U, polypeptide 1 148 9697 TRAM2 translocation 0,46380148 6,2584768 0,0006119 0,07888426 associated membrane protein 2

149 26058 GIGYF2 GRB10 interacting GYF 0,11061205 6,7238401 0,0006143 0,07888426 protein 2 150 123207 C15orf40 chromosome 15 open -0,1989364 9,0031646 0,0006162 0,07888426 reading frame 40

151 114804 RNF157 ring finger protein 157 -0,5687984 6,2612386 0,000617 0,07888426

152 2744 GLS glutaminase 0,46104772 7,49943 0,0006217 0,07888426 153 7280 TUBB2A tubulin, beta 2A class 0,2901005 14,006368 0,0006249 0,07888426 IIa 154 254228 FAM26E family with sequence 0,52533889 3,4717115 0,0006357 0,07888426 similarity 26, member E 155 192286 HIGD2A HIG1 hypoxia inducible -0,2613765 10,625345 0,0006491 0,07888426 domain family, member 2A 156 84102 SLC41A2 solute carrier family 41 0,39694907 4,9949265 0,0006508 0,07888426 (magnesium transporter), member 2 157 283991 UBALD2 UBA-like domain -0,3544446 7,497361 0,0006546 0,07888426 containing 2 158 1728 NQO1 NAD(P)H 0,7240295 11,879724 0,0006609 0,07888426 dehydrogenase, quinone 1 159 9588 PRDX6 peroxiredoxin 6 -0,2409738 13,571394 0,0006616 0,07888426 160 7422 VEGFA vascular endothelial -0,4912066 9,0261658 0,0006658 0,07888426 growth factor A 161 1938 EEF2 eukaryotic translation -0,1444421 14,185629 0,0006673 0,07888426 elongation factor 2

162 4724 NDUFS4 NADH dehydrogenase -0,157873 11,227601 0,0006694 0,07888426 (ubiquinone) Fe-S protein 4, 18kDa (NADH-coenzyme Q reductase)

163 51231 VRK3 vaccinia related kinase -0,2733897 6,253032 0,0006711 0,07888426 3 164 9223 MAGI1 membrane associated -0,1299732 5,6063845 0,000672 0,07888426 guanylate kinase, WW and PDZ domain containing 1

165 94274 PPP1R14A protein phosphatase 1, -0,5603669 10,928306 0,0006722 0,07888426 regulatory (inhibitor) subunit 14A

166 64083 GOLPH3 golgi phosphoprotein 3 0,10330765 11,820755 0,0006782 0,07888426 (coat-protein)

167 5911 RAP2A RAP2A, member of 0,29324264 8,9615268 0,0006819 0,07888426 RAS oncogene family

168 7345 UCHL1 ubiquitin carboxyl- 1,15387786 9,8112457 0,0006845 0,07888426 terminal esterase L1 (ubiquitin thiolesterase) 169 90864 SPSB3 splA/ryanodine -0,2864322 7,4274356 0,0006957 0,07888426 receptor domain and SOCS box containing 3 170 9146 HGS hepatocyte growth -0,3785625 6,3423919 0,0006995 0,07888426 factor-regulated tyrosine kinase substrate 171 197257 LDHD lactate dehydrogenase -0,7883669 6,6896045 0,0007002 0,07888426 D 172 26011 TENM4 teneurin 0,53465605 6,6085871 0,0007003 0,07888426 transmembrane protein 4 173 11315 PARK7 parkinson protein 7 -0,108001 13,491195 0,0007028 0,07888426 174 32 ACACB acetyl-CoA carboxylase -0,4140385 11,92918 0,0007042 0,07888426 beta 175 9189 ZBED1 zinc finger, BED-type -0,0997493 7,9326135 0,0007089 0,07888426 containing 1 176 100505894 TMEM161 TMEM161B antisense -0,5819594 4,4361458 0,0007133 0,07888426 B-AS1 RNA 1 177 56886 UGGT1 UDP-glucose 0,1618995 6,0298436 0,0007192 0,07888426 glycoprotein glucosyltransferase 1

178 10277 UBE4B ubiquitination factor -0,1638329 6,9163583 0,0007195 0,07888426 E4B 179 929 CD14 CD14 molecule 0,55412799 8,4034029 0,0007225 0,07888426 180 79987 SVEP1 sushi, von Willebrand 0,16554914 2,7221216 0,0007388 0,07888426 factor type A, EGF and pentraxin domain containing 1

181 7533 YWHAH tyrosine 3- 0,25465288 9,7891077 0,0007426 0,07888426 monooxygenase/trypt ophan 5- monooxygenase activation protein, eta

182 8644 AKR1C3 aldo-keto reductase 0,39491012 13,502155 0,000747 0,07888426 family 1, member C3

183 84910 TMEM87B transmembrane 0,324511 6,9287747 0,0007511 0,07888426 protein 87B 184 23136 EPB41L3 erythrocyte 0,49290061 9,2180844 0,0007534 0,07888426 membrane protein band 4.1-like 3 185 3684 ITGAM integrin, alpha M 1,00922781 5,8544409 0,0007582 0,07888426 (complement component 3 receptor 3 subunit) 186 10553 HTATIP2 HIV-1 Tat interactive 0,28958792 7,2096399 0,0007628 0,07888426 protein 2, 30kDa 187 57820 CCNB1IP1 cyclin B1 interacting -0,4084806 8,4034726 0,000766 0,07888426 protein 1, E3 ubiquitin protein ligase

188 4711 NDUFB5 NADH dehydrogenase -0,2219893 12,401622 0,0007697 0,07888426 (ubiquinone) 1 beta subcomplex, 5, 16kDa

189 4905 NSF N-ethylmaleimide- 0,24470272 8,7649076 0,0007703 0,07888426 sensitive factor 190 3055 HCK hemopoietic cell 0,85891702 4,0951641 0,000774 0,07888426 kinase 191 51295 ECSIT ECSIT signalling -0,329224 7,4062175 0,0007783 0,07888426 integrator 192 1632 ECI1 enoyl-CoA delta -0,4882379 8,7998443 0,0007842 0,07888426 isomerase 1 193 55248 TMEM206 transmembrane 0,65624108 3,5374691 0,0007864 0,07888426 protein 206 194 8428 STK24 serine/threonine -0,3234475 11,184801 0,0007865 0,07888426 kinase 24 195 57538 ALPK3 alpha-kinase 3 -1,0155768 4,8085446 0,0007871 0,07888426 196 4710 NDUFB4 NADH dehydrogenase -0,0601906 4,6650796 0,0008131 0,08073993 (ubiquinone) 1 beta subcomplex, 4, 15kDa

197 4702 NDUFA8 NADH dehydrogenase -0,254574 10,10211 0,0008195 0,08073993 (ubiquinone) 1 alpha subcomplex, 8, 19kDa

198 813 CALU calumenin 0,39772645 9,2686766 0,0008222 0,08073993 199 57583 TMEM181 transmembrane 0,29493902 9,1196177 0,0008246 0,08073993 protein 181 200 4522 MTHFD1 methylenetetrahydrof -0,2950953 12,119174 0,0008262 0,08073993 olate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofol ate cyclohydrolase, formyltetrahydrofolate synthetase

201 7311 UBA52 ubiquitin A-52 residue -0,1855643 13,44861 0,0008363 0,0813169 ribosomal protein fusion product 1 202 55691 FRMD4A FERM domain -0,1993006 9,3308729 0,0008409 0,08135805 containing 4A 203 57493 HEG1 heart development 0,43438901 7,9595509 0,0008472 0,08137434 protein with EGF-like domains 1 204 1978 EIF4EBP1 eukaryotic translation -0,6722725 8,5589794 0,0008563 0,08137434 initiation factor 4E binding protein 1

205 412 STS steroid sulfatase 0,29837183 7,5529111 0,0008571 0,08137434 (microsomal), isozyme S 206 293 SLC25A6 solute carrier family 25 -0,2127891 12,675491 0,0008617 0,08137434 (mitochondrial carrier; adenine nucleotide translocator), member 6

207 23313 KIAA0930 KIAA0930 0,38491178 4,7747561 0,0008619 0,08137434 208 10096 ACTR3 ARP3 actin-related 0,21824173 9,153073 0,0008683 0,08158407 protein 3 homolog (yeast) 209 51181 DCXR dicarbonyl/L-xylulose -0,402635 10,198467 0,0008738 0,08171429 reductase 210 338758 LINC00936 long intergenic non- 0,41813623 4,690122 0,0008811 0,08200098 protein coding RNA 936 211 9397 NMT2 N-myristoyltransferase 0,40354299 10,515896 0,0008965 0,08303425 2

212 5538 PPT1 palmitoyl-protein 0,27688009 10,942233 0,0009064 0,08355635 thioesterase 1 213 4337 MOCS1 molybdenum cofactor -0,7110195 8,1692537 0,0009174 0,08418132 synthesis 1 214 2495 FTH1 ferritin, heavy 0,3884254 11,932269 0,0009391 0,0845742 polypeptide 1 215 4357 MPST mercaptopyruvate -0,3422029 8,6781278 0,0009393 0,0845742 sulfurtransferase 216 84706 GPT2 glutamic pyruvate -0,4669438 8,3950144 0,0009426 0,0845742 transaminase (alanine aminotransferase) 2

217 9869 SETDB1 SET domain, bifurcated -0,1893885 4,8806974 0,0009459 0,0845742 1 218 79158 GNPTAB N-acetylglucosamine-1- 0,24077344 8,2160187 0,0009481 0,0845742 phosphate transferase, alpha and beta subunits

219 2817 GPC1 glypican 1 0,45748526 5,6677446 0,0009569 0,0845742 220 6390 SDHB succinate -0,1755056 10,72734 0,0009582 0,0845742 dehydrogenase complex, subunit B, iron sulfur (Ip) 221 1351 COX8A cytochrome c oxidase -0,1851819 11,964359 0,0009639 0,0845742 subunit VIIIA (ubiquitous) 222 54543 TOMM7 translocase of outer -0,1737364 13,384847 0,0009646 0,0845742 mitochondrial membrane 7 homolog (yeast) 223 5837 PYGM phosphorylase, -0,9741239 4,1306013 0,000965 0,0845742 glycogen, muscle 224 5274 SERPINI1 serpin peptidase -0,3547558 8,7932564 0,0009792 0,08534357 inhibitor, clade I (neuroserpin), member 1 225 92181 UBTD2 ubiquitin domain 0,24961282 8,552061 0,0009825 0,08534357 containing 2 226 10190 TXNDC9 thioredoxin domain 0,22894048 9,6113547 0,0009908 0,08548656 containing 9 227 27010 TPK1 thiamin 0,37763684 3,9933099 0,0010048 0,08548656 pyrophosphokinase 1

228 7381 UQCRB ubiquinol-cytochrome -0,1811691 7,6121709 0,0010063 0,08548656 c reductase binding protein

229 152137 CCDC50 coiled-coil domain -0,1781118 9,5718507 0,001007 0,08548656 containing 50 230 727910 TLCD2 TLC domain containing 0,45530807 10,070508 0,0010127 0,08548656 2 231 27286 SRPX2 sushi-repeat 0,75797708 8,8558102 0,0010149 0,08548656 containing protein, X- linked 2 232 80829 ZFP91 ZFP91 zinc finger 0,10533096 9,7567806 0,0010179 0,08548656 protein 233 54941 RNF125 ring finger protein 125, -0,5885943 8,1269061 0,0010242 0,08548656 E3 ubiquitin protein ligase 234 3028 HSD17B10 hydroxysteroid (17- -0,2091373 9,5431833 0,001033 0,08548656 beta) dehydrogenase 10 235 729 C6 complement -0,7180924 8,1005149 0,0010398 0,08548656 component 6 236 25975 EGFL6 EGF-like-domain, 2,50023751 8,5614719 0,0010488 0,08548656 multiple 6 237 55335 NIPSNAP3 nipsnap homolog 3B -0,6168736 9,0344384 0,0010515 0,08548656 B (C. elegans) 238 23383 MAU2 MAU2 sister chromatid -0,1386125 5,63084 0,0010531 0,08548656 cohesion factor

239 64102 TNMD tenomodulin 1,13374367 11,589467 0,0010591 0,08548656 240 7291 TWIST1 twist family bHLH -0,4099521 12,306134 0,0010606 0,08548656 transcription factor 1

241 84152 PPP1R1B protein phosphatase 1, -0,27969 9,8275942 0,0010606 0,08548656 regulatory (inhibitor) subunit 1B

242 122622 ADSSL1 adenylosuccinate -0,6533143 8,6910739 0,0010708 0,08548656 synthase like 1 243 5594 MAPK1 mitogen-activated 0,14047129 7,5047597 0,0010716 0,08548656 protein kinase 1 244 11157 LSM6 LSM6 homolog, U6 -0,2699811 10,499857 0,0010721 0,08548656 small nuclear RNA associated (S. cerevisiae) 245 11326 VSIG4 V-set and 1,79910888 6,111937 0,0010736 0,08548656 immunoglobulin domain containing 4 246 56997 ADCK3 aarF domain -0,4334673 9,1440442 0,001076 0,08548656 containing kinase 3 247 115416 MALSU1 mitochondrial -0,19123 11,33322 0,0010816 0,08558539 assembly of ribosomal large subunit 1

248 4926 NUMA1 nuclear mitotic -0,2461729 6,8524491 0,0010908 0,0859598 apparatus protein 1 249 115330 GPR146 G protein-coupled -0,5166786 9,7566679 0,0010952 0,08596193 receptor 146 250 3131 HLF hepatic leukemia -0,6704565 8,1617734 0,0011086 0,08666847 factor 251 55111 PLEKHJ1 pleckstrin homology -0,425154 7,3174219 0,0011139 0,08673013 domain containing, family J member 1

252 55897 MESP1 mesoderm posterior 1 -0,3940355 8,9494256 0,0011187 0,08673762 homolog (mouse)

253 5337 PLD1 phospholipase D1, -0,3424941 4,1378693 0,0011228 0,08673762 phosphatidylcholine- specific 254 1528 CYB5A cytochrome b5 type A -0,2624695 13,369777 0,0011381 0,08734059 (microsomal) 255 64065 PERP PERP, TP53 apoptosis 0,35123113 9,6181757 0,001146 0,08734059 effector 256 55228 PNMAL1 paraneoplastic Ma 0,80593378 4,8552096 0,0011466 0,08734059 antigen family-like 1

257 1889 ECE1 endothelin converting -0,3019865 7,1211599 0,001151 0,08734059 enzyme 1

258 7507 XPA xeroderma -0,1657944 8,1368142 0,0011646 0,08734059 pigmentosum, complementation group A 259 51637 C14orf166 chromosome 14 open -0,1063732 12,655401 0,0011703 0,08734059 reading frame 166

260 4881 NPR1 natriuretic peptide -0,3802579 9,0171318 0,0011756 0,08734059 receptor 1 261 22863 ATG14 autophagy related 14 -0,2125579 8,599723 0,0011794 0,08734059

262 28962 OSTM1 osteopetrosis 0,37881967 8,6896803 0,0011813 0,08734059 associated transmembrane protein 1 263 114876 OSBPL1A oxysterol binding -0,179175 11,913785 0,0011851 0,08734059 protein-like 1A 264 90441 ZNF622 zinc finger protein 622 -0,2008148 8,2710172 0,0011879 0,08734059

265 1536 CYBB cytochrome b-245, 1,07937365 5,4823965 0,0011885 0,08734059 beta polypeptide 266 5511 PPP1R8 protein phosphatase 1, -0,0889833 9,7187954 0,0011887 0,08734059 regulatory subunit 8

267 1327 COX4I1 cytochrome c oxidase -0,1748663 13,115203 0,0012019 0,08763188 subunit IV isoform 1

268 400258 C14orf180 chromosome 14 open -0,4176603 9,263722 0,0012049 0,08763188 reading frame 180

269 845 CASQ2 calsequestrin 2 -1,1930735 6,2947588 0,0012101 0,08763188 (cardiac muscle) 270 5264 PHYH phytanoyl-CoA 2- -0,1987038 12,115304 0,0012106 0,08763188 hydroxylase 271 53635 PTOV1 prostate tumor -0,295041 8,7275141 0,0012277 0,08796506 overexpressed 1 272 23417 MLYCD malonyl-CoA -0,3514467 7,1673674 0,0012325 0,08796506 decarboxylase 273 50484 RRM2B ribonucleotide 0,283176 10,520744 0,001233 0,08796506 reductase M2 B (TP53 inducible) 274 2246 FGF1 fibroblast growth 0,82379635 5,3972371 0,0012332 0,08796506 factor 1 (acidic) 275 27335 EIF3K eukaryotic translation -0,1881526 12,682186 0,0012484 0,08872576 initiation factor 3, subunit K

276 1303 COL12A1 collagen, type XII, 0,60543433 7,5319633 0,0012562 0,08895173 alpha 1 277 151887 CCDC80 coiled-coil domain 0,51549291 10,341587 0,0012607 0,08895173 containing 80 278 10623 POLR3C polymerase (RNA) III -0,2294559 7,6955086 0,0012746 0,08940604 (DNA directed) polypeptide C (62kD)

279 9262 STK17B serine/threonine 0,32872684 7,4578065 0,0012828 0,08940604 kinase 17b 280 55266 TMEM19 transmembrane 0,30700892 7,3880847 0,0012851 0,08940604 protein 19 281 80704 SLC19A3 solute carrier family 19 -0,4811213 11,095424 0,0012863 0,08940604 (thiamine transporter), member 3

282 6625 SNRNP70 small nuclear -0,2129731 8,1761373 0,0012938 0,08940604 ribonucleoprotein 70kDa (U1) 283 23030 KDM4B lysine (K)-specific -0,2561479 6,2706634 0,0013046 0,08940604 demethylase 4B 284 5534 PPP3R1 protein phosphatase 3, -0,2977865 10,168192 0,0013127 0,08940604 regulatory subunit B, alpha

285 6446 SGK1 serum/glucocorticoid 0,5587866 11,806613 0,0013155 0,08940604 regulated kinase 1 286 57124 CD248 CD248 molecule, 0,78401017 9,5685332 0,0013208 0,08940604 endosialin 287 54948 MRPL16 mitochondrial -0,1711164 9,5478251 0,0013277 0,08940604 ribosomal protein L16

288 203427 SLC25A43 solute carrier family 0,30761776 9,0604625 0,0013294 0,08940604 25, member 43 289 80315 CPEB4 cytoplasmic 0,45282907 9,0272433 0,0013347 0,08940604 polyadenylation element binding protein 4 290 9655 SOCS5 suppressor of cytokine 0,18139373 9,1490239 0,0013383 0,08940604 signaling 5 291 928 CD9 CD9 molecule 0,47750184 11,023671 0,0013432 0,08940604 292 4886 NPY1R neuropeptide Y 0,4247206 12,69976 0,0013438 0,08940604 receptor Y1 293 282991 BLOC1S2 biogenesis of 0,29168513 9,7466382 0,0013441 0,08940604 lysosomal organelles complex-1, subunit 2

294 8777 MPDZ multiple PDZ domain -0,3991909 9,6781998 0,0013449 0,08940604 protein 295 515 ATP5F1 ATP synthase, H+ -0,1244171 12,674159 0,0013519 0,08956488 transporting, mitochondrial Fo complex, subunit B1 296 64776 C11orf1 chromosome 11 open -0,3225054 8,5481464 0,0013614 0,08988903 reading frame 1

297 10613 ERLIN1 ER lipid raft associated 0,24812281 8,2157447 0,0013814 0,09089355 1 298 54331 GNG2 guanine nucleotide 0,37591105 7,6040768 0,0013945 0,09089355 binding protein (G protein), gamma 2 299 25828 TXN2 thioredoxin 2 -0,2424263 9,0829016 0,0013946 0,09089355 300 84836 ABHD14B abhydrolase domain -0,3483435 9,1587506 0,0014048 0,09089355 containing 14B

301 719 C3AR1 complement 1,20402348 6,0639636 0,0014076 0,09089355 component 3a receptor 1 302 8131 NPRL3 nitrogen permease -0,2329535 5,2371232 0,0014098 0,09089355 regulator-like 3 (S. cerevisiae) 303 153020 RASGEF1B RasGEF domain family, 0,44060302 4,4206923 0,0014137 0,09089355 member 1B 304 6576 SLC25A1 solute carrier family 25 -0,4520008 10,111911 0,0014138 0,09089355 (mitochondrial carrier; citrate transporter), member 1

305 3727 JUND jun D proto-oncogene -0,2286649 9,7544864 0,0014279 0,09139129

306 153129 SLC38A9 solute carrier family 0,27638035 6,0160287 0,0014309 0,09139129 38, member 9 307 200185 KRTCAP2 keratinocyte -0,1860268 11,675352 0,001442 0,09170849 associated protein 2 308 22 ABCB7 ATP-binding cassette, -0,230154 9,2683023 0,0014453 0,09170849 sub-family B (MDR/TAP), member 7

309 134549 SHROOM1 shroom family -0,1331227 3,8899978 0,0014519 0,09182838 member 1 310 8192 CLPP caseinolytic -0,182337 8,397878 0,0014717 0,0925327 mitochondrial matrix peptidase proteolytic subunit 311 441549 CDNF cerebral dopamine -0,2435367 3,4953707 0,0014742 0,0925327 neurotrophic factor 312 93653 ST7-AS1 ST7 antisense RNA 1 -0,540892 4,5903229 0,0014772 0,0925327 313 55816 DOK5 docking protein 5 0,38027088 7,0060962 0,0014906 0,09275139 314 55831 EMC3 ER membrane protein -0,1772949 11,553956 0,0014975 0,09275139 complex subunit 3

315 22926 ATF6 activating transcription 0,1624616 8,0532484 0,0015002 0,09275139 factor 6

316 64859 NABP1 nucleic acid binding 0,30413063 8,7066854 0,0015123 0,09275139 protein 1 317 5209 PFKFB3 6-phosphofructo-2- -0,2551219 14,359134 0,0015149 0,09275139 kinase/fructose-2,6- biphosphatase 3 318 4255 MGMT O-6-methylguanine- -0,2853961 8,0800843 0,0015159 0,09275139 DNA methyltransferase 319 83892 KCTD10 potassium channel 0,31910427 8,5674144 0,0015223 0,09275139 tetramerization domain containing 10

320 56133 PCDHB2 protocadherin beta 2 0,27112627 5,3519552 0,0015231 0,09275139

321 1030 CDKN2B cyclin-dependent 0,55956541 9,1877536 0,0015301 0,09275139 kinase inhibitor 2B (p15, inhibits CDK4) 322 10019 SH2B3 SH2B adaptor protein 0,37550699 8,2588741 0,0015325 0,09275139 3 323 4247 MGAT2 mannosyl (alpha-1,6-)- 0,12472506 8,2038504 0,0015329 0,09275139 glycoprotein beta-1,2- N- acetylglucosaminyltran sferase 324 3621 ING1 inhibitor of growth -0,2897957 7,8562189 0,0015484 0,09339881 family, member 1 325 6256 RXRA retinoid X receptor, -0,367345 8,0926723 0,0015903 0,09453769 alpha 326 79022 TMEM106 transmembrane -0,4632181 8,535508 0,0015938 0,09453769 C protein 106C 327 4067 LYN v-yes-1 Yamaguchi 0,36383925 5,9979924 0,0015968 0,09453769 sarcoma viral related oncogene homolog

328 2195 FAT1 FAT atypical cadherin 1 0,39730033 11,53827 0,0016013 0,09453769 329 2662 GDF10 growth differentiation 0,79734053 3,5012178 0,0016019 0,09453769 factor 10

330 6924 TCEB3 transcription -0,2144659 8,1331346 0,0016036 0,09453769 elongation factor B (SIII), polypeptide 3 (110kDa, elongin A) 331 1329 COX5B cytochrome c oxidase -0,2047422 11,488409 0,0016047 0,09453769 subunit Vb 332 6135 RPL11 ribosomal protein L11 -0,166275 14,364418 0,0016059 0,09453769

333 145270 PRIMA1 proline rich membrane -0,7090146 5,3621214 0,0016138 0,09464406 anchor 1 334 4644 MYO5A myosin VA (heavy 0,3310524 7,1415609 0,0016174 0,09464406 chain 12, myoxin) 335 55033 FKBP14 FK506 binding protein 0,3095787 7,6834144 0,001635 0,09503458 14, 22 kDa 336 55770 EXOC2 exocyst complex 0,22866155 5,5792651 0,0016354 0,09503458 component 2 337 670 BPHL biphenyl hydrolase-like -0,3514182 8,7434843 0,0016387 0,09503458 (serine hydrolase)

338 92106 OXNAD1 oxidoreductase NAD- -0,2272199 6,6049519 0,0016476 0,09526992 binding domain containing 1 339 26146 TRAF3IP1 TNF receptor- 0,15682682 7,8605593 0,0016658 0,09603542 associated factor 3 interacting protein 1

340 152007 GLIPR2 GLI pathogenesis- 0,57685011 9,2058639 0,0016933 0,09733314 related 2 341 1028 CDKN1C cyclin-dependent -0,4075803 10,916498 0,0017006 0,097354 kinase inhibitor 1C (p57, Kip2) 342 8671 SLC4A4 solute carrier family 4 -0,4998177 4,4402771 0,0017036 0,097354 (sodium bicarbonate cotransporter), member 4

343 1436 CSF1R colony stimulating 0,93889502 5,0137855 0,0017086 0,09735775 factor 1 receptor 344 4942 OAT ornithine 0,14538423 12,285561 0,0017298 0,09827424 aminotransferase 345 5091 PC pyruvate carboxylase -0,4920563 9,4145425 0,0017594 0,099445

346 9326 ZNHIT3 zinc finger, HIT-type -0,2019344 9,0914845 0,0017605 0,099445 containing 3 347 130399 ACVR1C activin A receptor, -0,3390534 11,659439 0,0017771 0,09954571 type IC 348 2788 GNG7 guanine nucleotide -0,4347235 3,484987 0,0017776 0,09954571 binding protein (G protein), gamma 7 349 760 CA2 carbonic anhydrase II -0,5904707 6,76152 0,0017818 0,09954571

350 374659 HDDC3 HD domain containing -0,2842064 7,94749 0,0017827 0,09954571 3 351 4175 MCM6 minichromosome -0,2050789 3,4584408 0,0017916 0,09958701 maintenance complex component 6

352 506 ATP5B ATP synthase, H+ -0,1887196 12,432213 0,0017936 0,09958701 transporting, mitochondrial F1 complex, beta polypeptide 353 84061 MAGT1 magnesium 0,19465235 9,9810048 0,0018081 0,09978116 transporter 1 354 51386 EIF3L eukaryotic translation -0,1938269 13,728883 0,0018159 0,09978116 initiation factor 3, subunit L

355 28992 MACROD1 MACRO domain -0,3171373 5,3640242 0,001826 0,09978116 containing 1 356 7385 UQCRC2 ubiquinol-cytochrome -0,21326 11,997772 0,0018305 0,09978116 c reductase core protein II

357 80206 FHOD3 formin homology 2 -1,0655579 3,4789827 0,0018599 0,09978116 domain containing 3 358 9781 RNF144A ring finger protein -0,6882174 8,6425145 0,0018654 0,09978116 144A 359 4478 MSN moesin 0,19145381 10,015698 0,0018654 0,09978116 360 18 ABAT 4-aminobutyrate -0,1963414 5,7665077 0,0018802 0,09978116 aminotransferase 361 26166 RGS22 regulator of G-protein -0,4233417 7,5796836 0,0018828 0,09978116 signaling 22 362 1508 CTSB cathepsin B 0,23651812 10,873091 0,0018856 0,09978116 363 1672 DEFB1 defensin, beta 1 0,78857618 5,2827323 0,0018881 0,09978116 364 5998 RGS3 regulator of G-protein -0,7409923 5,8179736 0,0018891 0,09978116 signaling 3 365 10512 SEMA3C sema domain, 0,39362812 10,700804 0,0018896 0,09978116 immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 366 1959 EGR2 early growth response 0,5815441 10,455452 0,001893 0,09978116 2 367 9332 CD163 CD163 molecule 1,39834891 7,5347008 0,0018959 0,09978116 368 7384 UQCRC1 ubiquinol-cytochrome -0,2183329 10,760297 0,0019033 0,09978116 c reductase core protein I

369 2872 MKNK2 MAP kinase interacting -0,3269653 11,510572 0,001915 0,09978116 serine/threonine kinase 2

370 64288 ZSCAN31 zinc finger and SCAN -0,2198487 5,2898976 0,0019316 0,09978116 domain containing 31

371 81493 SYNC syncoilin, intermediate 0,5716782 9,0081458 0,0019334 0,09978116 filament protein

372 57551 TAOK1 TAO kinase 1 0,23215889 9,1964004 0,0019365 0,09978116 373 8971 H1FX H1 histone family, -0,3743898 9,4719197 0,0019449 0,09978116 member X 374 4616 GADD45B growth arrest and DNA- -0,3862652 13,28495 0,0019503 0,09978116 damage-inducible, beta 375 2907 GRINA glutamate receptor, -0,3659775 8,0788783 0,0019516 0,09978116 ionotropic, N-methyl D- aspartate-associated protein 1 (glutamate binding) 376 92293 TMEM132 transmembrane -0,4373892 10,002553 0,0019538 0,09978116 C protein 132C 377 79086 SMIM7 small integral -0,1105176 7,7423209 0,0019562 0,09978116 membrane protein 7

378 56912 IFT46 intraflagellar transport -0,2561486 7,4235982 0,0019617 0,09978116 46 homolog (Chlamydomonas)

379 2222 FDFT1 farnesyl-diphosphate -0,2543939 11,953264 0,0019666 0,09978116 farnesyltransferase 1

380 8853 ASAP2 ArfGAP with SH3 0,18546154 10,21436 0,0019754 0,09978116 domain, ankyrin repeat and PH domain 2 381 126823 KLHDC9 kelch domain -0,3411526 5,4177285 0,0019772 0,09978116 containing 9 382 116843 SLC18B1 solute carrier family 0,53139344 6,8547459 0,0019844 0,09978116 18, subfamily B, member 1 383 1537 CYC1 cytochrome c-1 -0,283318 10,586679 0,0019858 0,09978116 384 56902 PNO1 partner of NOB1 0,18151508 8,753576 0,001987 0,09978116 homolog (S. cerevisiae)

385 115123 MARCH3 membrane-associated -0,4211086 5,9321059 0,0019894 0,09978116 ring finger (C3HC4) 3, E3 ubiquitin protein ligase

386 56984 PSMG2 proteasome (prosome, -0,135243 11,998437 0,0019949 0,09978116 macropain) assembly chaperone 2

387 5154 PDGFA platelet-derived 0,59447248 4,8665103 0,0019956 0,09978116 growth factor alpha polypeptide 388 93100 NAPRT1 nicotinate -0,3821474 7,4532294 0,0019958 0,09978116 phosphoribosyltransfe rase domain containing 1 389 2995 GYPC glycophorin C (Gerbich -0,2647654 11,850778 0,0019969 0,09978116 blood group)

390 64231 MS4A6A membrane-spanning 4- 1,24964235 6,2956598 0,0020097 0,09978116 domains, subfamily A, member 6A

391 517 ATP5G2 ATP synthase, H+ -0,252143 11,504416 0,0020161 0,09978116 transporting, mitochondrial Fo complex, subunit C2 (subunit 9) 392 221061 FAM171A1 family with sequence 0,37259899 8,9116377 0,0020166 0,09978116 similarity 171, member A1 393 215 ABCD1 ATP-binding cassette, -0,368159 6,2174861 0,0020178 0,09978116 sub-family D (ALD), member 1 394 55313 CPPED1 calcineurin-like 0,31147147 7,7898333 0,0020211 0,09978116 phosphoesterase domain containing 1 395 9968 MED12 mediator complex -0,3299884 5,7516285 0,0020251 0,09978116 subunit 12 396 51646 YPEL5 yippee-like 5 -0,2532153 11,890069 0,0020266 0,09978116 (Drosophila) 397 10171 RCL1 RNA terminal -0,3195468 8,6076213 0,0020286 0,09978116 phosphate cyclase-like 1 398 56301 SLC7A10 solute carrier family 7 -0,9467182 7,2325019 0,002032 0,09978116 (neutral amino acid transporter light chain, asc system), member 10

399 9846 GAB2 GRB2-associated -0,2966172 8,5313127 0,0020687 0,10132924 binding protein 2 400 100506380 LINC01006 long intergenic non- -0,7120714 5,1024636 0,0021016 0,10266147 protein coding RNA 1006 401 23171 GPD1L glycerol-3-phosphate -0,6411365 10,23403 0,0021128 0,10266147 dehydrogenase 1-like

402 3735 KARS lysyl-tRNA synthetase -0,1646508 11,334519 0,002114 0,10266147

403 388335 TMEM220 transmembrane -0,3237472 8,8012237 0,002117 0,10266147 protein 220 404 6626 SNRPA small nuclear -0,2897184 8,9930266 0,0021261 0,10266147 ribonucleoprotein polypeptide A 405 400916 CHCHD10 coiled-coil-helix-coiled- -0,4353207 10,30518 0,0021292 0,10266147 coil-helix domain containing 10

406 57136 APMAP adipocyte plasma -0,2220882 11,966638 0,0021386 0,10266147 membrane associated protein 407 647087 C7orf73 chromosome 7 open 0,25434677 8,718338 0,0021467 0,10266147 reading frame 73

408 9780 PIEZO1 piezo-type -0,2807481 9,8035039 0,002154 0,10266147 mechanosensitive ion channel component 1

409 8673 VAMP8 vesicle-associated 0,61225559 8,2391417 0,0021582 0,10266147 membrane protein 8

410 1350 COX7C cytochrome c oxidase -0,3903208 9,627263 0,0021621 0,10266147 subunit VIIc 411 93129 ORAI3 ORAI calcium release- -0,2547501 7,3142544 0,0021636 0,10266147 activated calcium modulator 3 412 84749 USP30 ubiquitin specific -0,3437064 8,2649637 0,0021692 0,10266147 peptidase 30 413 6124 RPL4 ribosomal protein L4 -0,1388862 14,051655 0,0021694 0,10266147 414 593 BCKDHA branched chain keto -0,3680995 7,7635717 0,0021888 0,10293549 acid dehydrogenase E1, alpha polypeptide

415 79161 TMEM243 transmembrane -0,2679505 9,6303208 0,0021906 0,10293549 protein 243, mitochondrial 416 158326 FREM1 FRAS1 related 0,4999989 5,3953242 0,0022082 0,10293549 extracellular matrix 1

417 10455 ECI2 enoyl-CoA delta -0,1633952 10,66663 0,0022088 0,10293549 isomerase 2 418 1191 CLU clusterin 0,45076284 12,88291 0,0022117 0,10293549 419 284611 FAM102B family with sequence 0,46201523 8,1172501 0,0022134 0,10293549 similarity 102, member B 420 54840 APTX aprataxin -0,127499 6,9336418 0,0022137 0,10293549 421 285 ANGPT2 angiopoietin 2 0,72618945 4,5902732 0,0022173 0,10293549 422 65005 MRPL9 mitochondrial -0,198579 9,0978764 0,0022232 0,1029606 ribosomal protein L9

423 9917 FAM20B family with sequence 0,16461015 8,9306322 0,0022393 0,1034608 similarity 20, member B 424 10128 LRPPRC leucine-rich -0,1646528 9,4365226 0,002246 0,10348725 pentatricopeptide repeat containing 425 5981 RFC1 replication factor C -0,174763 8,7024815 0,002257 0,10348725 (activator 1) 1, 145kDa

426 23608 MKRN1 makorin ring finger -0,1769683 8,3831891 0,0022589 0,10348725 protein 1 427 10594 PRPF8 pre-mRNA processing -0,2432762 9,2633703 0,002261 0,10348725 factor 8 428 2213 FCGR2B Fc fragment of IgG, 1,28064054 6,7593493 0,0022705 0,10367758 low affinity IIb, receptor (CD32) 429 80896 NPL N-acetylneuraminate 0,5519638 2,9997786 0,0022789 0,10382092 pyruvate lyase (dihydrodipicolinate synthase)

430 130074 FAM168B family with sequence -0,095304 8,6032379 0,0022914 0,10408955 similarity 168, member B 431 4659 PPP1R12A protein phosphatase 1, 0,21524147 9,621103 0,0022955 0,10408955 regulatory subunit 12A 432 64417 C5orf28 chromosome 5 open 0,36355808 8,3001403 0,0023166 0,10476321 reading frame 28

433 116154 PHACTR3 phosphatase and actin 0,84338781 5,3885437 0,002321 0,10476321 regulator 3 434 79165 LENG1 leukocyte receptor -0,3573061 4,3487398 0,0023324 0,10503511 cluster (LRC) member 1 435 283 ANG angiogenin, -0,3987061 9,147055 0,0023446 0,10515361 ribonuclease, RNase A family, 5 436 219972 MPEG1 macrophage expressed 1,15995764 7,0381824 0,0023458 0,10515361 1 437 25943 C20orf194 chromosome 20 open 0,17083258 8,3073049 0,0023578 0,10544647 reading frame 194

438 143941 TTC36 tetratricopeptide -1,1531504 4,2294321 0,0023847 0,10626184 repeat domain 36 439 4666 NACA nascent polypeptide- -0,1317788 14,061883 0,0023903 0,10626184 associated complex alpha subunit

440 84803 AGPAT9 1-acylglycerol-3- -1,5095415 6,4046841 0,0023923 0,10626184 phosphate O- acyltransferase 9 441 131118 DNAJC19 DnaJ (Hsp40) homolog, -0,1415642 8,2490005 0,0024127 0,10667103 subfamily C, member 19 442 7695 ZNF136 zinc finger protein 136 -0,3184428 5,9909854 0,0024155 0,10667103

443 84140 FAM161A family with sequence -0,4710736 3,1382882 0,0024179 0,10667103 similarity 161, member A 444 100128750 RBPMS- RBPMS antisense RNA -0,4293549 6,7333582 0,0024263 0,1068026 AS1 1 445 2581 GALC galactosylceramidase 0,18350288 4,9810168 0,0024414 0,10693275

446 1879 EBF1 early B-cell factor 1 -0,1434302 13,094929 0,0024447 0,10693275 447 54878 DPP8 dipeptidyl-peptidase 8 0,08406758 9,4569372 0,0024457 0,10693275

448 253461 ZBTB38 zinc finger and BTB 0,1543093 7,5188653 0,0024642 0,10733522 domain containing 38

449 57205 ATP10D ATPase, class V, type 0,4810396 6,5207773 0,0024704 0,10733522 10D 450 253827 MSRB3 methionine sulfoxide 0,33215218 9,972202 0,0024733 0,10733522 reductase B3 451 64975 MRPL41 mitochondrial -0,1780965 10,418934 0,0024855 0,10733522 ribosomal protein L41

452 3693 ITGB5 integrin, beta 5 0,38994372 10,135544 0,0024892 0,10733522 453 8975 USP13 ubiquitin specific -0,310215 6,9708772 0,0024917 0,10733522 peptidase 13 (isopeptidase T-3) 454 375387 NRROS negative regulator of 0,41125631 4,2352421 0,0024934 0,10733522 reactive oxygen species 455 54996 MARC2 mitochondrial -0,2087302 9,4547087 0,0025108 0,10784942 amidoxime reducing component 2

456 2108 ETFA electron-transfer- -0,2645361 12,360353 0,0025419 0,10824927 flavoprotein, alpha polypeptide 457 3030 HADHA hydroxyacyl-CoA -0,1415493 11,015254 0,0025447 0,10824927 dehydrogenase/3- ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit

458 55608 ANKRD10 ankyrin repeat domain -0,1716746 9,3219212 0,0025469 0,10824927 10 459 5361 PLXNA1 plexin A1 0,12342014 4,1842054 0,002555 0,10824927 460 79639 TMEM53 transmembrane -0,270229 5,5281403 0,0025558 0,10824927 protein 53 461 81888 HYI hydroxypyruvate -0,4205414 8,7801233 0,0025571 0,10824927 isomerase (putative)

462 11336 EXOC3 exocyst complex -0,2474669 7,5392004 0,0025589 0,10824927 component 3 463 7162 TPBG trophoblast 0,63347708 8,3758706 0,0025702 0,10825383 glycoprotein 464 6351 CCL4 chemokine (C-C motif) 1,17786133 10,969205 0,002588 0,10825383 ligand 4 465 80760 ITIH5 inter-alpha-trypsin 0,48512161 12,24979 0,0025882 0,10825383 inhibitor heavy chain family, member 5

466 80762 NDFIP1 Nedd4 family 0,13582127 10,88461 0,0025926 0,10825383 interacting protein 1

467 4601 MXI1 MAX interactor 1, -0,4450123 10,26298 0,0025954 0,10825383 dimerization protein 468 91283 MSANTD3 Myb/SANT-like DNA- 0,2252129 7,0777035 0,0025971 0,10825383 binding domain containing 3 469 128637 TBC1D20 TBC1 domain family, -0,2114781 7,4867859 0,0025978 0,10825383 member 20 470 26100 WIPI2 WD repeat domain, -0,1252627 7,3726395 0,0026165 0,10880194 phosphoinositide interacting 2 471 118424 UBE2J2 ubiquitin-conjugating -0,1108979 6,3717521 0,0026386 0,10913721 enzyme E2, J2

472 55602 CDKN2AIP CDKN2A interacting -0,2653509 9,0052898 0,0026405 0,10913721 protein 473 10575 CCT4 chaperonin containing -0,172684 11,361599 0,0026474 0,10913721 TCP1, subunit 4 (delta)

474 91624 NEXN nexilin (F actin binding 0,55409564 9,0408409 0,0026486 0,10913721 protein) 475 25839 COG4 component of -0,2922724 7,3322244 0,002656 0,10913721 oligomeric golgi complex 4 476 6782 HSPA13 heat shock protein 0,34054265 7,6744805 0,0026581 0,10913721 70kDa family, member 13 477 388789 LINC00493 long intergenic non- -0,139052 10,749366 0,0026705 0,10920985 protein coding RNA 493 478 27314 RAB30 RAB30, member RAS 0,41296884 7,3269814 0,002671 0,10920985 oncogene family

479 56271 BEX4 brain expressed, X- -0,2302593 8,9123563 0,0026826 0,10945403 linked 4 480 2589 GALNT1 UDP-N-acetyl-alpha-D- 0,3235906 9,802967 0,0027045 0,1101193 galactosamine:polypep tide N- acetylgalactosaminyltr ansferase 1 (GalNAc- T1)

481 900 CCNG1 cyclin G1 -0,2158546 12,524794 0,0027285 0,11086648 482 7086 TKT transketolase -0,2247574 11,102502 0,0027446 0,11128773 483 2149 F2R coagulation factor II 0,69722723 6,4670106 0,0027635 0,11180267 (thrombin) receptor 484 151195 CCNYL1 cyclin Y-like 1 0,23241808 9,0671636 0,0027688 0,11180267 485 8408 ULK1 unc-51 like autophagy -0,3566787 5,7963854 0,0027962 0,11267639 activating kinase 1

486 7905 REEP5 receptor accessory 0,1365693 11,462688 0,0028076 0,1126933 protein 5 487 60481 ELOVL5 ELOVL fatty acid -0,203463 13,824761 0,0028101 0,1126933 elongase 5 488 2009 EML1 echinoderm 0,28749555 7,5444686 0,0028139 0,1126933 microtubule associated protein like 1 489 9724 UTP14C UTP14, U3 small 0,19020693 9,1526742 0,0028257 0,11271251 nucleolar ribonucleoprotein, homolog C (yeast) 490 6945 MLX MLX, MAX -0,2774614 8,6573464 0,0028296 0,11271251 dimerization protein

491 3418 IDH2 isocitrate -0,3380007 7,1723538 0,0028317 0,11271251 dehydrogenase 2 (NADP+), mitochondrial 492 26873 OPLAH 5-oxoprolinase (ATP- -0,4083066 6,0912824 0,0028389 0,11276319 hydrolysing) 493 339983 NAT8L N-acetyltransferase 8- -0,3397681 9,4886595 0,0028532 0,11276319 like (GCN5-related, putative) 494 38 ACAT1 acetyl-CoA -0,2022205 8,8432894 0,0028546 0,11276319 acetyltransferase 1 495 285362 SUMF1 sulfatase modifying 0,22809189 10,586867 0,002856 0,11276319 factor 1 496 51313 FAM198B family with sequence 0,53942147 9,4964301 0,0028625 0,11279344 similarity 198, member B 497 120 ADD3 adducin 3 (gamma) -0,16572 10,682134 0,0028941 0,11357914 498 55250 ELP2 elongator -0,2713931 8,7062967 0,0028941 0,11357914 acetyltransferase complex subunit 2 499 84893 FBXO18 F-box protein, -0,1273319 8,3584098 0,0029158 0,11393544 helicase, 18 500 57488 ESYT2 extended 0,10070218 9,4807417 0,0029205 0,11393544 synaptotagmin-like protein 2 501 6535 SLC6A8 solute carrier family 6 -0,523755 7,826991 0,0029247 0,11393544 (neurotransmitter transporter), member 8 502 23023 TMCC1 transmembrane and 0,27134784 7,5539678 0,0029265 0,11393544 coiled-coil domain family 1 503 197131 UBR1 ubiquitin protein ligase 0,26652258 8,1955117 0,0029351 0,11393544 E3 component n- recognin 1 504 6517 SLC2A4 solute carrier family 2 -0,6749503 3,7238517 0,0029382 0,11393544 (facilitated glucose transporter), member 4

505 129285 PPP1R21 protein phosphatase 1, 0,12293024 7,7986475 0,0029468 0,11404508 regulatory subunit 21

506 183 AGT angiotensinogen -0,7160588 6,5519748 0,0029646 0,11450517 (serpin peptidase inhibitor, clade A, member 8) 507 23028 KDM1A lysine (K)-specific -0,1629826 7,6646906 0,002976 0,11471929 demethylase 1A 508 539 ATP5O ATP synthase, H+ -0,102054 13,599789 0,0030051 0,11537211 transporting, mitochondrial F1 complex, O subunit 509 4688 NCF2 neutrophil cytosolic 0,73764525 4,2141342 0,0030203 0,11537211 factor 2 510 53373 TPCN1 two pore segment -0,0957132 5,3399636 0,0030258 0,11537211 channel 1 511 348 APOE apolipoprotein E -0,6046665 10,841868 0,0030259 0,11537211 512 54994 GID8 GID complex subunit 8 -0,1766026 7,9222236 0,0030355 0,11537211

513 51107 APH1A APH1A gamma -0,1849752 8,6149786 0,003047 0,11537211 secretase subunit 514 122961 ISCA2 iron-sulfur cluster -0,1891125 8,2296878 0,0030492 0,11537211 assembly 2 515 6817 SULT1A1 sulfotransferase 0,43178716 11,239724 0,0030541 0,11537211 family, cytosolic, 1A, phenol-preferring, member 1

516 6470 SHMT1 serine -0,3907904 9,8336434 0,003059 0,11537211 hydroxymethyltransfer ase 1 (soluble) 517 4893 NRAS neuroblastoma RAS 0,19455543 7,8596738 0,0030597 0,11537211 viral (v-ras) oncogene homolog 518 1491 CTH cystathionase -0,7231142 6,5921324 0,0030715 0,11537211 (cystathionine gamma- lyase) 519 2885 GRB2 growth factor receptor- 0,11659285 8,936094 0,0030774 0,11537211 bound protein 2

520 51081 MRPS7 mitochondrial -0,1857084 8,8642742 0,0030805 0,11537211 ribosomal protein S7 521 123283 TARSL2 threonyl-tRNA -0,1474911 6,2888758 0,0030822 0,11537211 synthetase-like 2 522 10472 ZBTB18 zinc finger and BTB 0,09158223 5,2044605 0,0030979 0,11537211 domain containing 18

523 51768 TM7SF3 transmembrane 7 0,18000025 7,2468291 0,0030983 0,11537211 superfamily member 3

524 10781 ZNF266 zinc finger protein 266 -0,2184798 7,9459433 0,0031005 0,11537211

525 5153 PDE1B phosphodiesterase 1B, -0,5459859 3,5578662 0,0031034 0,11537211 calmodulin-dependent

526 50628 GEMIN4 gem (nuclear -0,1351441 4,2960905 0,0031148 0,11537211 organelle) associated protein 4 527 55421 C17orf85 chromosome 17 open -0,1334439 6,2259295 0,0031172 0,11537211 reading frame 85

528 50854 C6orf48 chromosome 6 open -0,1797469 10,437414 0,0031237 0,11537211 reading frame 48

529 5256 PHKA2 phosphorylase kinase, -0,2410193 7,32479 0,0031263 0,11537211 alpha 2 (liver)

530 379 ARL4D ADP-ribosylation -0,5502088 6,9032418 0,0031313 0,11537211 factor-like 4D 531 5900 RALGDS ral guanine nucleotide -0,266413 8,8411356 0,003136 0,11537211 dissociation stimulator

532 689 BTF3 basic transcription -0,1240247 12,628374 0,0031405 0,11537211 factor 3 533 56474 CTPS2 CTP synthase 2 -0,1600726 6,435547 0,0031574 0,11560088 534 56674 TMEM9B TMEM9 domain 0,25412601 7,5762882 0,0031586 0,11560088 family, member B 535 10049 DNAJB6 DnaJ (Hsp40) homolog, 0,16017201 9,495707 0,0031755 0,11585977 subfamily B, member 6

536 64772 ENGASE endo-beta-N- -0,1290324 4,9931748 0,0031884 0,11585977 acetylglucosaminidase

537 84268 RPAIN RPA interacting -0,1184521 3,8802623 0,0031884 0,11585977 protein 538 4841 NONO non-POU domain -0,1221391 9,8626404 0,0031927 0,11585977 containing, octamer- binding 539 284454 LOC28445 uncharacterized 0,35086647 9,4333167 0,0031983 0,11585977 4 LOC284454 540 5394 EXOSC10 exosome component -0,2724894 8,5502591 0,0032012 0,11585977 10 541 29105 C16orf80 chromosome 16 open -0,2036509 10,290951 0,0032246 0,11629174 reading frame 80

542 11030 RBPMS RNA binding protein -0,3087816 8,8565334 0,003225 0,11629174 with multiple splicing

543 3479 IGF1 insulin-like growth -0,46956 11,860169 0,0032319 0,11632578 factor 1 (somatomedin C) 544 55857 KIZ kizuna centrosomal -0,2307468 8,5111359 0,0032383 0,11634088 protein 545 23554 TSPAN12 tetraspanin 12 0,24031729 5,2019983 0,0032577 0,11671058 546 64960 MRPS15 mitochondrial -0,1971591 11,523954 0,0032612 0,11671058 ribosomal protein S15

547 5269 SERPINB6 serpin peptidase -0,2214658 9,2886065 0,0032738 0,11671058 inhibitor, clade B (ovalbumin), member 6 548 7316 UBC ubiquitin C -0,1096652 14,805575 0,0032758 0,11671058 549 349136 WDR86 WD repeat domain 86 -0,5804583 4,7516309 0,0032785 0,11671058

550 120114 FAT3 FAT atypical cadherin 3 -0,8016318 5,7686041 0,0032946 0,11707275

551 9871 SEC24D SEC24 family member 0,57369558 6,6293392 0,003301 0,11708802 D 552 199 AIF1 allograft inflammatory 0,41849858 4,0755758 0,0033229 0,11748699 factor 1

553 30011 SH3KBP1 SH3-domain kinase -0,1829882 10,474403 0,0033243 0,11748699 binding protein 1 554 60370 AVPI1 arginine vasopressin- -0,3847842 9,583629 0,0033327 0,11751431 induced 1

555 10159 ATP6AP2 ATPase, H+ 0,22519208 12,119718 0,0033428 0,11751431 transporting, lysosomal accessory protein 2 556 7515 XRCC1 X-ray repair -0,3332954 6,1963167 0,0033431 0,11751431 complementing defective repair in Chinese hamster cells 1 557 427 ASAH1 N-acylsphingosine 0,28322704 13,420218 0,0033496 0,11753119 amidohydrolase (acid ceramidase) 1 558 78988 MRPL57 mitochondrial -0,14662 9,0353322 0,003379 0,11831359 ribosomal protein L57

559 1439 CSF2RB colony stimulating 1,10867274 5,3089157 0,003384 0,11831359 factor 2 receptor, beta, low-affinity (granulocyte- macrophage) 560 7163 TPD52 tumor protein D52 0,1832852 4,1135191 0,0033912 0,1183534 561 3600 IL15 interleukin 15 0,58577812 5,3770114 0,0034104 0,11872903 562 117285 DEFB118 defensin, beta 118 -0,142208 2,7903452 0,0034195 0,11872903 563 80318 GKAP1 G kinase anchoring -0,3464121 8,5917072 0,0034278 0,11872903 protein 1 564 6146 RPL22 ribosomal protein L22 -0,143486 11,901419 0,0034306 0,11872903

565 730112 FAM166B family with sequence -0,3415266 2,5817631 0,0034324 0,11872903 similarity 166, member B 566 10618 TGOLN2 trans-golgi network 0,19245117 8,6426257 0,0034606 0,11947047 protein 2 567 6039 RNASE6 ribonuclease, RNase A 0,72534405 3,8311026 0,003466 0,11947047 family, k6 568 80832 APOL4 apolipoprotein L, 4 -1,009071 4,8702082 0,0034825 0,11967921 569 58475 MS4A7 membrane-spanning 4- 1,19550577 6,8975054 0,0034843 0,11967921 domains, subfamily A, member 7

570 26353 HSPB8 heat shock 22kDa 0,22700153 10,770267 0,0034976 0,11968636 protein 8 571 27163 NAAA N-acylethanolamine 0,33009706 4,5977007 0,003509 0,11968636 acid amidase

572 79888 LPCAT1 lysophosphatidylcholin 0,34336536 6,9605714 0,003513 0,11968636 e acyltransferase 1

573 90313 TP53I13 tumor protein p53 -0,2283535 6,9686484 0,0035204 0,11968636 inducible protein 13 574 80000 GREB1L growth regulation by -0,4643388 3,0937966 0,0035209 0,11968636 estrogen in breast cancer-like 575 23362 PSD3 pleckstrin and Sec7 0,2869309 5,8341082 0,0035213 0,11968636 domain containing 3 576 3148 HMGB2 high mobility group -0,4171505 11,79463 0,0035345 0,11992847 box 2 577 23 ABCF1 ATP-binding cassette, -0,1646572 8,1810692 0,0035571 0,12035656 sub-family F (GCN20), member 1 578 27109 ATP5S ATP synthase, H+ -0,1600489 7,529621 0,0035618 0,12035656 transporting, mitochondrial Fo complex, subunit s (factor B) 579 55379 LRRC59 leucine rich repeat 0,2531749 9,0833851 0,0035656 0,12035656 containing 59 580 4194 MDM4 MDM4, p53 regulator -0,1630281 5,8823033 0,003601 0,12116467

581 308 ANXA5 annexin A5 0,22399022 13,727959 0,003602 0,12116467 582 284004 HEXDC hexosaminidase -0,3534946 2,8677908 0,0036262 0,1216377 (glycosyl hydrolase family 20, catalytic domain) containing 583 9592 IER2 immediate early -0,3123754 12,633532 0,0036344 0,1216377 response 2 584 22920 KIFAP3 kinesin-associated 0,16221686 9,3319916 0,0036348 0,1216377 protein 3 585 6776 STAT5A signal transducer and -0,299583 10,098074 0,0036409 0,1216377 activator of transcription 5A 586 25940 FAM98A family with sequence 0,25009872 10,697991 0,003661 0,12209996 similarity 98, member A 587 57470 LRRC47 leucine rich repeat -0,1754498 11,055752 0,0036849 0,12257157 containing 47 588 65123 INTS3 integrator complex -0,1994554 7,7113159 0,0036877 0,12257157 subunit 3 589 682 BSG basigin (Ok blood -0,2974876 8,4356897 0,0037076 0,12302505 group) 590 2782 GNB1 guanine nucleotide 0,144836 10,559852 0,0037241 0,12336129 binding protein (G protein), beta polypeptide 1 591 51035 UBXN1 UBX domain protein 1 -0,1618998 5,6790326 0,0037356 0,12343539

592 100859930 HEIH hepatocellular -0,2554339 9,6347111 0,0037452 0,12343539 carcinoma up- regulated EZH2- associated long non- coding RNA 593 10943 MSL3 male-specific lethal 3 0,09339598 6,4786125 0,0037525 0,12343539 homolog (Drosophila)

594 140733 MACROD2 MACRO domain -0,4064617 6,5988325 0,0037554 0,12343539 containing 2 595 25896 INTS7 integrator complex 0,46069809 4,9768124 0,0037631 0,12343539 subunit 7 596 10456 HAX1 HCLS1 associated -0,1683118 10,6926 0,0037674 0,12343539 protein X-1 597 10489 LRRC41 leucine rich repeat -0,159672 7,9270897 0,0037705 0,12343539 containing 41 598 11010 GLIPR1 GLI pathogenesis- 0,79215386 4,9743696 0,003788 0,12379933 related 1 599 4883 NPR3 natriuretic peptide 0,9292438 6,5296152 0,0038285 0,12491516 receptor 3 600 51192 CKLF chemokine-like factor 0,42693814 5,6486803 0,003845 0,12524531

601 84661 DPY30 dpy-30 homolog (C. -0,1360536 10,426273 0,0038614 0,12538615 elegans) 602 1615 DARS aspartyl-tRNA -0,13237 11,684907 0,0038685 0,12538615 synthetase 603 5092 PCBD1 pterin-4 alpha- -0,432831 8,2525792 0,0038686 0,12538615 carbinolamine dehydratase/dimerizat ion cofactor of hepatocyte nuclear factor 1 alpha 604 1362 CPD carboxypeptidase D 0,18795482 8,1349446 0,0038843 0,12556322 605 10428 CFDP1 craniofacial -0,2175545 9,2589407 0,0038869 0,12556322 development protein 1

606 101928061 LOC10192 uncharacterized -0,4238924 5,2516489 0,0039005 0,1257271 8061 LOC101928061 607 509 ATP5C1 ATP synthase, H+ -0,1450437 12,161756 0,0039048 0,1257271 transporting, mitochondrial F1 complex, gamma polypeptide 1 608 2764 GMFB glia maturation factor, 0,32171995 8,3598388 0,0039272 0,12606853 beta 609 10628 TXNIP thioredoxin interacting -0,2858299 13,731197 0,0039341 0,12606853 protein 610 80019 UBTD1 ubiquitin domain -0,3960093 6,0876246 0,0039348 0,12606853 containing 1 611 6156 RPL30 ribosomal protein L30 -0,105793 14,83558 0,0039489 0,12631448

612 112611 RWDD2A RWD domain -0,4306531 4,5103121 0,0039686 0,12673468 containing 2A 613 9377 COX5A cytochrome c oxidase -0,1508863 12,786503 0,0039866 0,12678136 subunit Va 614 1780 DYNC1I1 dynein, cytoplasmic 1, 0,09431086 2,4458498 0,0039885 0,12678136 intermediate chain 1

615 11100 HNRNPUL heterogeneous nuclear -0,2259956 8,2038693 0,0039895 0,12678136 1 ribonucleoprotein U- like 1

616 23450 SF3B3 splicing factor 3b, -0,1115773 6,8547428 0,0040074 0,12701046 subunit 3, 130kDa 617 55758 RCOR3 REST corepressor 3 -0,2569699 9,0034639 0,0040097 0,12701046 618 10884 MRPS30 mitochondrial -0,21209 7,9967907 0,004017 0,12703483 ribosomal protein S30

619 29080 CCDC59 coiled-coil domain -0,2594165 9,7407793 0,004029 0,12716367 containing 59 620 83719 YPEL3 yippee-like 3 -0,2764798 10,262567 0,0040341 0,12716367 (Drosophila) 621 55362 TMEM63B transmembrane -0,267506 6,3109645 0,0040581 0,12757972 protein 63B 622 113 ADCY7 adenylate cyclase 7 0,29424706 6,5159734 0,0040603 0,12757972 623 92609 TIMM50 translocase of inner -0,1679394 8,7934413 0,0040706 0,12769891 mitochondrial membrane 50 homolog (S. cerevisiae)

624 11260 XPOT exportin, tRNA 0,16851138 11,914595 0,0040913 0,12795604 625 119504 ANAPC16 anaphase promoting -0,1114355 11,054323 0,0040919 0,12795604 complex subunit 16

626 10105 PPIF peptidylprolyl -0,2902126 9,605837 0,0041179 0,12845094 isomerase F 627 3476 IGBP1 immunoglobulin -0,2939588 11,111564 0,0041331 0,12845094 (CD79A) binding protein 1 628 1266 CNN3 calponin 3, acidic 0,16295025 12,076075 0,0041367 0,12845094 629 9441 MED26 mediator complex -0,2092503 5,0646434 0,0041451 0,12845094 subunit 26 630 5861 RAB1A RAB1A, member RAS 0,17495056 10,977729 0,0041484 0,12845094 oncogene family

631 55022 PID1 phosphotyrosine 0,23919137 8,2580866 0,00415 0,12845094 interaction domain containing 1 632 153 ADRB1 adrenoceptor beta 1 -0,5194122 7,7853888 0,0041552 0,12845094 633 10990 LILRB5 leukocyte 0,89661726 4,150891 0,0041603 0,12845094 immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 5

634 27306 HPGDS hematopoietic 0,86145512 4,6849745 0,0041888 0,129125 prostaglandin D synthase 635 51135 IRAK4 interleukin-1 receptor- 0,24363264 4,7136349 0,0042231 0,12966874 associated kinase 4

636 64375 IKZF4 IKAROS family zinc -0,4210646 5,5276168 0,0042238 0,12966874 finger 4 (Eos) 637 55032 SLC35A5 solute carrier family 0,23439824 8,0992275 0,0042388 0,12966874 35, member A5 638 112483 SAT2 spermidine/spermine -0,1474133 9,938807 0,0042389 0,12966874 N1-acetyltransferase family member 2

639 146223 CMTM4 CKLF-like MARVEL 0,03827077 5,034121 0,0042504 0,12966874 transmembrane domain containing 4 640 125 ADH1B alcohol dehydrogenase -0,2923302 14,730492 0,0042579 0,12966874 1B (class I), beta polypeptide

641 84973 SNHG7 small nucleolar RNA -0,1865796 3,6553415 0,0042591 0,12966874 host gene 7 (non- protein coding) 642 154 ADRB2 adrenoceptor beta 2, -0,4497319 9,0074425 0,0042595 0,12966874 surface 643 490 ATP2B1 ATPase, Ca++ 0,53018298 6,6526526 0,004284 0,12991377 transporting, plasma membrane 1 644 51253 MRPL37 mitochondrial -0,1839302 9,5052589 0,0042881 0,12991377 ribosomal protein L37

645 713 C1QB complement 1,20623549 6,9402663 0,0043025 0,12991377 component 1, q subcomponent, B chain 646 51809 GALNT7 UDP-N-acetyl-alpha-D- 0,41920304 5,420912 0,0043026 0,12991377 galactosamine:polypep tide N- acetylgalactosaminyltr ansferase 7 (GalNAc- T7)

647 440503 PLIN5 perilipin 5 -0,4905768 6,586195 0,0043069 0,12991377 648 26136 TES testis derived 0,45545117 7,6315673 0,0043074 0,12991377 transcript (3 LIM domains) 649 1230 CCR1 chemokine (C-C motif) 0,80252494 4,3042729 0,0043233 0,13019224 receptor 1 650 51306 FAM13B family with sequence 0,19585861 8,3047437 0,004344 0,1306135 similarity 13, member B 651 27189 IL17C interleukin 17C -0,216623 3,9556092 0,0043598 0,13088654 652 23175 LPIN1 lipin 1 -0,6756857 9,4958906 0,0043855 0,13110904 653 26227 PHGDH phosphoglycerate -0,4203958 8,888377 0,0044058 0,13110904 dehydrogenase 654 64969 MRPS5 mitochondrial -0,1666769 7,5642382 0,0044099 0,13110904 ribosomal protein S5

655 1290 COL5A2 collagen, type V, alpha 0,36927134 11,768465 0,0044189 0,13110904 2 656 7923 HSD17B8 hydroxysteroid (17- -0,3377182 7,3717765 0,0044256 0,13110904 beta) dehydrogenase 8

657 2218 FKTN fukutin 0,4166248 5,5522973 0,0044266 0,13110904 658 10440 TIMM17A translocase of inner 0,18948028 9,3095272 0,0044294 0,13110904 mitochondrial membrane 17 homolog A (yeast) 659 6812 STXBP1 syntaxin binding -0,1959854 10,231467 0,0044348 0,13110904 protein 1 660 6138 RPL15 ribosomal protein L15 -0,1192009 13,59626 0,0044392 0,13110904

661 64860 ARMCX5 armadillo repeat -0,2727419 7,4345283 0,0044456 0,13110904 containing, X-linked 5

662 9349 RPL23 ribosomal protein L23 -0,0977621 14,992152 0,0044508 0,13110904

663 221895 JAZF1 JAZF zinc finger 1 0,16952877 8,7122464 0,0044545 0,13110904 664 26151 NAT9 N-acetyltransferase 9 -0,3834627 5,5815508 0,004457 0,13110904 (GCN5-related, putative) 665 10641 NPRL2 nitrogen permease -0,1091361 7,4650526 0,0044611 0,13110904 regulator-like 2 (S. cerevisiae) 666 5879 RAC1 ras-related C3 0,08996584 12,511759 0,0045132 0,1323148 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)

667 388 RHOB ras homolog family -0,3213739 9,4109912 0,0045157 0,1323148 member B 668 9353 SLIT2 slit homolog 2 0,49436043 6,739402 0,0045266 0,13243659 (Drosophila) 669 22818 COPZ1 coatomer protein -0,1236852 9,5466175 0,00455 0,13292342 complex, subunit zeta 1 670 23558 WBP2 WW domain binding -0,3249314 8,4813424 0,0045633 0,13311143 protein 2 671 55858 TMEM165 transmembrane 0,28889548 9,6660361 0,0045807 0,13323682 protein 165 672 51545 ZNF581 zinc finger protein 581 -0,367609 6,4106669 0,0045812 0,13323682

673 55037 PTCD3 pentatricopeptide -0,131013 6,4533026 0,0045911 0,13332544 repeat domain 3 674 25926 NOL11 nucleolar protein 11 0,10381858 8,881242 0,0046182 0,13391509 675 5048 PAFAH1B1 platelet-activating 0,19298243 8,138947 0,0046407 0,13436586 factor acetylhydrolase 1b, regulatory subunit 1 (45kDa)

676 64757 MARC1 mitochondrial -0,2681582 12,042696 0,0046966 0,13572035 amidoxime reducing component 1

677 1964 EIF1AX eukaryotic translation 0,11851367 10,575166 0,0047013 0,13572035 initiation factor 1A, X- linked

678 7812 CSDE1 cold shock domain 0,1322681 13,070053 0,004709 0,13574193 containing E1, RNA- binding 679 6429 SRSF4 serine/arginine-rich -0,2176531 10,457307 0,0047186 0,13581648 splicing factor 4 680 6169 RPL38 ribosomal protein L38 -0,1674713 13,691966 0,0047862 0,13756215

681 80267 EDEM3 ER degradation 0,45453492 7,9469802 0,0048059 0,13767846 enhancer, mannosidase alpha- like 3 682 55967 NDUFA12 NADH dehydrogenase -0,1019575 11,926265 0,0048118 0,13767846 (ubiquinone) 1 alpha subcomplex, 12

683 8458 TTF2 transcription 0,35360564 7,3112831 0,0048173 0,13767846 termination factor, RNA polymerase II 684 27440 CECR5 cat eye syndrome -0,1870853 7,602858 0,0048185 0,13767846 chromosome region, candidate 5 685 80223 RAB11FIP1 RAB11 family -0,5976207 7,5214844 0,0048304 0,13772728 interacting protein 1 (class I) 686 54704 PDP1 pyruvate 0,25813994 6,557361 0,0048343 0,13772728 dehyrogenase phosphatase catalytic subunit 1 687 148979 GLIS1 GLIS family zinc finger -0,7217285 4,0364151 0,0048451 0,13774143 1 688 5569 PKIA protein kinase (cAMP- -0,248147 2,4905649 0,0048489 0,13774143 dependent, catalytic) inhibitor alpha 689 23433 RHOQ ras homolog family 0,22817959 11,218286 0,0048764 0,13832369 member Q 690 51279 C1RL complement 0,23745811 7,2047484 0,0048848 0,13836133 component 1, r subcomponent-like 691 1968 EIF2S3 eukaryotic translation -0,1309283 11,733074 0,0048929 0,13839008 initiation factor 2, subunit 3 gamma, 52kDa

692 55803 ADAP2 ArfGAP with dual PH 0,32306593 3,0988882 0,004913 0,13856378 domains 2 693 137075 CLDN23 claudin 23 -0,3505582 5,9422286 0,0049133 0,13856378 694 9572 NR1D1 nuclear receptor -0,492382 8,2274956 0,004931 0,13879585 subfamily 1, group D, member 1 695 595 CCND1 cyclin D1 0,68453134 10,013728 0,0049357 0,13879585 696 91689 SMDT1 single-pass membrane -0,1742611 10,227205 0,0049529 0,13904699 protein with aspartate- rich tail 1

697 587 BCAT2 branched chain amino- -0,397077 6,2020557 0,0049588 0,13904699 acid transaminase 2, mitochondrial

698 9258 MFHAS1 malignant fibrous 0,36288153 5,390136 0,0049917 0,13976785 histiocytoma amplified sequence 1

699 8501 SLC43A1 solute carrier family 43 -0,620011 5,5563989 0,0050265 0,14053979 (amino acid system L transporter), member 1

700 9276 COPB2 coatomer protein 0,15168156 11,400085 0,0050573 0,1412004 complex, subunit beta 2 (beta prime) 701 23510 KCTD2 potassium channel -0,4314168 5,0350272 0,0051079 0,14211427 tetramerization domain containing 2 702 65993 MRPS34 mitochondrial -0,1708438 8,4300616 0,0051158 0,14211427 ribosomal protein S34

703 171017 ZNF384 zinc finger protein 384 -0,2466731 6,7347642 0,0051192 0,14211427

704 10233 LRRC23 leucine rich repeat -0,2745251 2,8895935 0,0051277 0,14211427 containing 23 705 91851 CHRDL1 chordin-like 1 0,19070998 13,7632 0,0051303 0,14211427 706 6927 HNF1A HNF1 homeobox A -0,1032528 2,5443773 0,0051337 0,14211427 707 90326 THAP3 THAP domain -0,1597409 4,1573261 0,0051411 0,14211793 containing, apoptosis associated protein 3

708 253558 LCLAT1 lysocardiolipin 0,3016311 7,4806885 0,0051548 0,14212826 acyltransferase 1 709 80097 MZT2B mitotic spindle -0,2159299 9,2789334 0,005156 0,14212826 organizing protein 2B

710 3420 IDH3B isocitrate -0,1896088 9,1611303 0,0051853 0,14254018 dehydrogenase 3 (NAD+) beta 711 441951 ZFAS1 ZNFX1 antisense RNA 1 -0,3008653 11,436122 0,0051855 0,14254018

712 7803 PTP4A1 protein tyrosine -0,2378275 9,8855079 0,0052053 0,14288213 phosphatase type IVA, member 1 713 157506 RDH10 retinol dehydrogenase -0,3147941 9,3907312 0,0052609 0,14420539 10 (all-trans)

714 112936 VPS26B vacuolar protein -0,2334266 6,990625 0,0052753 0,14439738 sorting 26 homolog B (S. pombe) 715 10483 SEC23B Sec23 homolog B (S. 0,17806353 7,2300607 0,0052949 0,1447317 cerevisiae) 716 85458 DIXDC1 DIX domain containing 0,17028375 7,2234804 0,0053137 0,1449458 1 717 11015 KDELR3 KDEL (Lys-Asp-Glu-Leu) 0,25434818 7,4882362 0,0053175 0,1449458 endoplasmic reticulum protein retention receptor 3 718 100507602 TRIM52- TRIM52 antisense RNA -0,1214518 5,5261475 0,0053354 0,14511847 AS1 1 (head to head)

719 23239 PHLPP1 PH domain and leucine -0,5874098 6,7631317 0,0053454 0,14511847 rich repeat protein phosphatase 1

720 140739 UBE2F ubiquitin-conjugating 0,12685096 8,7237177 0,0053462 0,14511847 enzyme E2F (putative)

721 162073 ITPRIPL2 inositol 1,4,5- 0,23199534 9,8379228 0,0053563 0,1451908 trisphosphate receptor interacting protein-like 2 722 493753 COA5 cytochrome c oxidase -0,1812112 7,9814117 0,0053745 0,14542186 assembly factor 5 723 6830 SUPT6H suppressor of Ty 6 -0,2179986 5,7772055 0,0053802 0,14542186 homolog (S. cerevisiae)

724 8611 PPAP2A phosphatidic acid 0,30152381 12,758841 0,0053871 0,14542186 phosphatase type 2A

725 51750 RTEL1 regulator of telomere -0,247537 7,0129057 0,0054095 0,1457598 elongation helicase 1

726 126 ADH1C alcohol dehydrogenase -0,3477466 9,0976384 0,0054145 0,1457598 1C (class I), gamma polypeptide

727 51655 RASD1 RAS, dexamethasone- -0,2148163 13,315813 0,0054351 0,145934 induced 1

728 57176 VARS2 valyl-tRNA synthetase -0,2852104 7,6036819 0,0054385 0,145934 2, mitochondrial

729 9342 SNAP29 synaptosomal- -0,1374085 6,6805288 0,0054434 0,145934 associated protein, 29kDa 730 79020 C7orf25 chromosome 7 open 0,18177315 6,3479208 0,0054547 0,14603778 reading frame 25

731 123920 CMTM3 CKLF-like MARVEL 0,30886299 7,6179896 0,0054635 0,14607157 transmembrane domain containing 3 732 285527 FRYL FRY-like 0,14567333 7,2379584 0,0055046 0,14697057 733 22887 FOXJ3 forkhead box J3 -0,1710421 8,1445519 0,00555 0,14798067 734 5886 RAD23A RAD23 homolog A (S. -0,2256696 9,6809497 0,0055718 0,14835868 cerevisiae) 735 2639 GCDH glutaryl-CoA -0,3563334 7,3744142 0,0056206 0,14930235 dehydrogenase 736 84975 MFSD5 major facilitator 0,21744929 6,8642869 0,0056225 0,14930235 superfamily domain containing 5 737 231 AKR1B1 aldo-keto reductase 0,20789745 10,309752 0,0056377 0,14932523 family 1, member B1 (aldose reductase)

738 23399 CTDNEP1 CTD nuclear envelope -0,249521 7,8813278 0,0056446 0,14932523 phosphatase 1

739 714 C1QC complement 1,058364 8,1870344 0,005653 0,14932523 component 1, q subcomponent, C chain 740 9197 SLC33A1 solute carrier family 33 0,22665395 7,7678671 0,0056571 0,14932523 (acetyl-CoA transporter), member 1 741 5358 PLS3 plastin 3 0,20386088 13,186357 0,0056641 0,14932523 742 54928 IMPAD1 inositol 0,24963793 10,306437 0,0056754 0,14932523 monophosphatase domain containing 1 743 4722 NDUFS3 NADH dehydrogenase -0,1963545 9,5395373 0,0056769 0,14932523 (ubiquinone) Fe-S protein 3, 30kDa (NADH-coenzyme Q reductase)

744 51734 MSRB1 methionine sulfoxide -0,205195 8,0272643 0,0056977 0,14956872 reductase B1

745 221955 DAGLB diacylglycerol lipase, -0,0473583 3,0938832 0,0057079 0,14956872 beta 746 6433 SFSWAP splicing factor, -0,1593791 7,4572936 0,0057216 0,14956872 suppressor of white- apricot homolog (Drosophila) 747 9328 GTF3C5 general transcription -0,3052534 7,1252038 0,0057228 0,14956872 factor IIIC, polypeptide 5, 63kDa

748 4015 LOX lysyl oxidase 0,55108234 7,8574272 0,0057244 0,14956872 749 23336 SYNM synemin, intermediate 0,25315805 11,16113 0,0057658 0,15013386 filament protein

750 55339 WDR33 WD repeat domain 33 -0,1234691 4,2734224 0,0057679 0,15013386

751 387893 SETD8 SET domain containing 0,35849896 4,9719061 0,0057757 0,15013386 (lysine methyltransferase) 8

752 58191 CXCL16 chemokine (C-X-C 0,46233855 4,8824759 0,0057767 0,15013386 motif) ligand 16 753 6185 RPN2 ribophorin II 0,24087616 11,29619 0,005789 0,15020234 754 84255 SLC37A3 solute carrier family 0,17935171 8,6128879 0,0057947 0,15020234 37, member 3 755 388588 SMIM1 small integral -0,258619 4,4208024 0,0058098 0,15039304 membrane protein 1 (Vel blood group) 756 9638 FEZ1 fasciculation and 0,34874545 4,2501605 0,0058509 0,15125747 elongation protein zeta 1 (zygin I) 757 9404 LPXN leupaxin 0,39417895 4,7253298 0,0058651 0,15142308 758 90861 HN1L hematological and -0,1400765 6,8457084 0,0058786 0,15157265 neurological expressed 1-like 759 2908 NR3C1 nuclear receptor -0,2374804 11,569159 0,0059027 0,15180241 subfamily 3, group C, member 1 (glucocorticoid receptor) 760 80705 TSGA10 testis specific, 10 -0,5049664 6,359726 0,0059031 0,15180241 761 1880 GPR183 G protein-coupled 1,33656758 9,8232602 0,0059305 0,15219836 receptor 183 762 56987 BBX bobby sox homolog 0,23513793 8,1709836 0,0059587 0,15219836 (Drosophila) 763 9989 PPP4R1 protein phosphatase 4, 0,13363587 9,2560864 0,0059589 0,15219836 regulatory subunit 1

764 2207 FCER1G Fc fragment of IgE, 0,78541605 7,7606129 0,0059798 0,15219836 high affinity I, receptor for; gamma polypeptide 765 100093630 SNHG8 small nucleolar RNA -0,2036435 9,3951703 0,0059801 0,15219836 host gene 8 (non- protein coding) 766 64976 MRPL40 mitochondrial -0,1771877 9,9478721 0,0059802 0,15219836 ribosomal protein L40

767 4973 OLR1 oxidized low density 1,25732444 5,5461711 0,0059803 0,15219836 lipoprotein (lectin-like) receptor 1

768 10400 PEMT phosphatidylethanola 0,44429755 10,448135 0,0059808 0,15219836 mine N- methyltransferase 769 1479 CSTF3 cleavage stimulation 0,17964804 6,5855468 0,0059898 0,15222943 factor, 3' pre-RNA, subunit 3, 77kDa

770 4706 NDUFAB1 NADH dehydrogenase -0,1282346 12,498696 0,0060073 0,15247614 (ubiquinone) 1, alpha/beta subcomplex, 1, 8kDa

771 3751 KCND2 potassium voltage- 0,85050757 4,781559 0,0060171 0,15249769 gated channel, Shal- related subfamily, member 2 772 7867 MAPKAPK mitogen-activated -0,184467 5,8168269 0,0060238 0,15249769 3 protein kinase- activated protein kinase 3 773 64393 ZMAT3 zinc finger, matrin- 0,28636535 7,1538534 0,0060348 0,15258003 type 3 774 4848 CNOT2 CCR4-NOT -0,1166354 9,636357 0,0060678 0,15293992 transcription complex, subunit 2 775 1979 EIF4EBP2 eukaryotic translation -0,1838942 8,9783343 0,0060808 0,15293992 initiation factor 4E binding protein 2

776 7469 NELFA negative elongation -0,2233256 7,0747672 0,0060854 0,15293992 factor complex member A 777 9045 RPL14 ribosomal protein L14 -0,1795542 13,897921 0,0060919 0,15293992

778 4720 NDUFS2 NADH dehydrogenase -0,1355241 10,712037 0,0060921 0,15293992 (ubiquinone) Fe-S protein 2, 49kDa (NADH-coenzyme Q reductase)

779 116362 RBP7 retinol binding protein -0,4246246 11,771158 0,006096 0,15293992 7, cellular 780 91860 CALML4 calmodulin-like 4 0,24903506 3,3866172 0,0061127 0,15316304 781 4345 CD200 CD200 molecule 0,24173138 5,7777796 0,0061232 0,15322845 782 2202 EFEMP1 EGF containing fibulin- 0,33519413 12,016714 0,0061823 0,15375309 like extracellular matrix protein 1

783 963 CD53 CD53 molecule 1,19355379 6,7329851 0,0061898 0,15375309 784 4628 MYH10 myosin, heavy chain -0,2809853 10,240719 0,0061939 0,15375309 10, non-muscle 785 375061 FAM89A family with sequence -0,2900464 10,186039 0,0061962 0,15375309 similarity 89, member A 786 140461 ASB8 ankyrin repeat and -0,1358532 8,5846704 0,0062317 0,15375309 SOCS box containing 8

787 23277 CLUH clustered -0,2989141 8,5930848 0,006232 0,15375309 mitochondria (cluA/CLU1) homolog

788 26073 POLDIP2 polymerase (DNA- -0,1388407 8,4349983 0,0062375 0,15375309 directed), delta interacting protein 2

789 6913 TBX15 T-box 15 -0,3284176 8,559849 0,0062437 0,15375309 790 716 C1S complement 0,61354664 10,664532 0,0062516 0,15375309 component 1, s subcomponent 791 79726 WDR59 WD repeat domain 59 -0,0511161 2,5376389 0,006254 0,15375309

792 55703 POLR3B polymerase (RNA) III 0,21633764 5,706613 0,0062609 0,15375309 (DNA directed) polypeptide B 793 84311 MRPL45 mitochondrial -0,1586248 8,3395061 0,0062639 0,15375309 ribosomal protein L45

794 10894 LYVE1 lymphatic vessel 1,24280926 7,5433575 0,0062659 0,15375309 endothelial hyaluronan receptor 1

795 301 ANXA1 annexin A1 0,18186088 14,134538 0,0062681 0,15375309 796 1315 COPB1 coatomer protein 0,1148478 11,45139 0,0062695 0,15375309 complex, subunit beta 1 797 4733 DRG1 developmentally -0,1767933 10,910286 0,0062901 0,15375309 regulated GTP binding protein 1 798 5066 PAM peptidylglycine alpha- 0,22685606 12,068007 0,0062932 0,15375309 amidating monooxygenase 799 948 CD36 CD36 molecule 0,08802228 14,755178 0,0063 0,15375309 (thrombospondin receptor) 800 23279 NUP160 nucleoporin 160kDa 0,05072126 4,3063241 0,0063025 0,15375309 801 10810 WASF3 WAS protein family, 0,15421755 10,488269 0,0063075 0,15375309 member 3 802 84674 CARD6 caspase recruitment 0,28633845 8,9143324 0,0063133 0,15375309 domain family, member 6 803 401548 SNX30 sorting nexin family 0,1611213 7,0428833 0,0063244 0,15375309 member 30 804 286205 SCAI suppressor of cancer -0,3480773 4,0078859 0,0063251 0,15375309 cell invasion 805 1459 CSNK2A2 casein kinase 2, alpha -0,3513719 7,972051 0,0063686 0,15461841 prime polypeptide

806 253559 CADM2 cell adhesion molecule -0,3741977 3,5886474 0,0063939 0,15503908 2 807 26509 MYOF myoferlin 0,39576792 9,2509824 0,0064112 0,15526611 808 84787 SUV420H2 suppressor of -0,2077668 4,0440638 0,006433 0,15560305 variegation 4-20 homolog 2 (Drosophila) 809 85021 REPS1 RALBP1 associated Eps -0,2031776 8,5154219 0,0064507 0,15583851 domain containing 1

810 3936 LCP1 lymphocyte cytosolic 0,99293777 6,4491173 0,00648 0,15635102 protein 1 (L-plastin)

811 57403 RAB22A RAB22A, member RAS 0,17998057 8,3475371 0,0064937 0,15649037 oncogene family

812 55002 TMCO3 transmembrane and 0,25420471 8,1989841 0,006516 0,15670869 coiled-coil domains 3

813 23335 WDR7 WD repeat domain 7 0,24030892 8,1816107 0,0065188 0,15670869

814 22850 ADNP2 ADNP homeobox 2 -0,320028 8,0112705 0,0065296 0,15673698 815 23204 ARL6IP1 ADP-ribosylation -0,1312126 12,746366 0,0065361 0,15673698 factor-like 6 interacting protein 1

816 55970 GNG12 guanine nucleotide 0,301748 8,4017931 0,0065626 0,15718014 binding protein (G protein), gamma 12 817 6197 RPS6KA3 ribosomal protein S6 0,21627316 8,7141127 0,0066108 0,15797145 kinase, 90kDa, polypeptide 3 818 6745 SSR1 signal sequence 0,1242743 9,810945 0,0066118 0,15797145 receptor, alpha 819 8816 DCAF5 DDB1 and CUL4 -0,120473 7,8195543 0,0066229 0,15804505 associated factor 5 820 64149 C17orf75 chromosome 17 open -0,1303831 7,392064 0,0066463 0,15823035 reading frame 75

821 56945 MRPS22 mitochondrial -0,1997632 9,3751428 0,0066634 0,15823035 ribosomal protein S22

822 154141 MBOAT1 membrane bound O- 0,40346269 4,9814188 0,0066645 0,15823035 acyltransferase domain containing 1 823 128346 C1orf162 chromosome 1 open 0,57300583 4,4541938 0,0066768 0,15823035 reading frame 162

824 54510 PCDH18 protocadherin 18 -0,2719378 9,3585941 0,0066831 0,15823035 825 9019 MPZL1 myelin protein zero- 0,14214219 6,9123773 0,0066961 0,15823035 like 1 826 8204 NRIP1 nuclear receptor -0,3403348 12,177733 0,0067014 0,15823035 interacting protein 1

827 118980 SFXN2 sideroflexin 2 -0,3802858 4,7386336 0,0067025 0,15823035 828 4363 ABCC1 ATP-binding cassette, 0,32254859 6,9129334 0,0067036 0,15823035 sub-family C (CFTR/MRP), member 1 829 8550 MAPKAPK mitogen-activated -0,1462725 7,7876529 0,0067351 0,15876828 5 protein kinase- activated protein kinase 5 830 10960 LMAN2 lectin, mannose- -0,2224453 7,9914017 0,0067426 0,15876828 binding 2 831 9863 MAGI2 membrane associated -0,2495614 7,0697411 0,0067853 0,15958109 guanylate kinase, WW and PDZ domain containing 2

832 51339 DACT1 dishevelled-binding 0,67014887 3,7259105 0,0067987 0,15958483 antagonist of beta- catenin 1 833 8491 MAP4K3 mitogen-activated 0,26362269 10,262614 0,0068038 0,15958483 protein kinase kinase kinase kinase 3

834 2690 GHR growth hormone -0,1757412 13,852777 0,00681 0,15958483 receptor 835 54536 EXOC6 exocyst complex 0,2345605 4,820321 0,0068484 0,16029432 component 6 836 11161 C14orf1 chromosome 14 open -0,2608373 7,3168254 0,0068801 0,16084258 reading frame 1

837 1997 ELF1 E74-like factor 1 (ets 0,27422468 9,601909 0,0069012 0,16106562 domain transcription factor) 838 286753 TUSC5 tumor suppressor -0,2552933 10,586033 0,006909 0,16106562 candidate 5 839 1396 CRIP1 cysteine-rich protein 1 0,70878663 10,930215 0,0069195 0,16106562 (intestinal)

840 11019 LIAS lipoic acid synthetase -0,2956702 7,0446999 0,0069309 0,16106562

841 401152 C4orf3 chromosome 4 open 0,15366277 11,764011 0,0069385 0,16106562 reading frame 3

842 91949 COG7 component of -0,2186822 6,2207383 0,0069433 0,16106562 oligomeric golgi complex 7 843 1119 CHKA choline kinase alpha -0,4211158 5,924163 0,0069473 0,16106562

844 55068 ENOX1 ecto-NOX disulfide- -0,552808 5,0472038 0,0069838 0,16171975 thiol exchanger 1 845 2822 GPLD1 glycosylphosphatidylin 0,37898031 5,4082344 0,0070174 0,16218972 ositol specific phospholipase D1 846 55819 RNF130 ring finger protein 130 -0,2475539 11,408244 0,0070207 0,16218972

847 26121 PRPF31 pre-mRNA processing -0,1551677 8,0704643 0,0070826 0,16289381 factor 31 848 10561 IFI44 interferon-induced 0,50439775 6,6882334 0,0070844 0,16289381 protein 44 849 6362 CCL18 chemokine (C-C motif) 1,26905429 5,5993032 0,0070858 0,16289381 ligand 18 (pulmonary and activation- regulated)

850 4123 MAN2C1 mannosidase, alpha, -0,2578399 5,5928403 0,0070864 0,16289381 class 2C, member 1

851 7918 GPANK1 G patch domain and -0,1711119 5,6371448 0,0070928 0,16289381 ankyrin repeats 1 852 58477 SRPRB signal recognition 0,1499196 7,0555474 0,0071038 0,16295402 particle receptor, B subunit 853 90024 FLJ20021 uncharacterized -0,1825343 7,6645631 0,0071188 0,16309812 LOC90024 854 23612 PHLDA3 pleckstrin homology- -0,2775051 10,17722 0,0071268 0,16309812 like domain, family A, member 3

855 8038 ADAM12 ADAM 0,42976954 8,1846675 0,0071455 0,16323654 metallopeptidase domain 12 856 664 BNIP3 BCL2/adenovirus E1B -0,217448 12,428382 0,0071495 0,16323654 19kDa interacting protein 3

857 91603 ZNF830 zinc finger protein 830 0,10226829 7,3777227 0,0072094 0,16402846

858 51668 HSPB11 heat shock protein -0,1400344 8,3726393 0,0072203 0,16402846 family B (small), member 11 859 26574 AATF apoptosis antagonizing -0,2390141 9,6312962 0,0072272 0,16402846 transcription factor

860 10228 STX6 syntaxin 6 0,19611899 6,097997 0,0072301 0,16402846 861 22985 ACIN1 apoptotic chromatin -0,2087577 7,1459222 0,0072402 0,16402846 condensation inducer 1 862 7737 RNF113A ring finger protein -0,2067372 7,0693418 0,0072427 0,16402846 113A 863 79091 METTL22 methyltransferase like -0,3334639 7,0715584 0,007243 0,16402846 22 864 57690 TNRC6C trinucleotide repeat -0,033202 2,6504292 0,0072567 0,16407515 containing 6C 865 56985 ADPRM ADP-ribose/CDP- -0,1338962 5,0895271 0,0072649 0,16407515 alcohol diphosphatase, manganese-dependent

866 9662 CEP135 centrosomal protein 0,31119465 5,358024 0,0072728 0,16407515 135kDa 867 8825 LIN7A lin-7 homolog A (C. -0,4611062 2,6398455 0,0072786 0,16407515 elegans) 868 90 ACVR1 activin A receptor, -0,3712941 9,9937 0,0072926 0,16409944 type I 869 414919 C8orf82 chromosome 8 open -0,3758393 7,4038845 0,007297 0,16409944 reading frame 82

870 6767 ST13 suppression of -0,1551886 11,982427 0,0073076 0,16409944 tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein) 871 10399 GNB2L1 guanine nucleotide -0,1195701 14,652532 0,0073205 0,16409944 binding protein (G protein), beta polypeptide 2-like 1 872 644096 SDHAF1 succinate -0,2162045 6,9924743 0,0073262 0,16409944 dehydrogenase complex assembly factor 1 873 54467 ANKIB1 ankyrin repeat and IBR 0,08150928 9,1276302 0,0073374 0,16409944 domain containing 1

874 4689 NCF4 neutrophil cytosolic 0,45753019 2,7607541 0,007355 0,16409944 factor 4, 40kDa 875 26035 GLCE glucuronic acid 0,28616802 7,5299963 0,0073571 0,16409944 epimerase 876 51399 TRAPPC4 trafficking protein -0,1332085 9,572547 0,0073597 0,16409944 particle complex 4 877 545 ATR ataxia telangiectasia 0,30103685 9,1484563 0,0073674 0,16409944 and Rad3 related

878 100505641 FGD5-AS1 FGD5 antisense RNA 1 0,15732498 11,883073 0,007373 0,16409944

879 23743 BHMT2 betaine--homocysteine 0,26363807 11,020877 0,0073804 0,16409944 S-methyltransferase 2

880 134957 STXBP5 syntaxin binding 0,18093737 5,7959542 0,007432 0,16489346 protein 5 (tomosyn) 881 1725 DHPS deoxyhypusine -0,2474007 7,353334 0,0074341 0,16489346 synthase 882 3460 IFNGR2 interferon gamma -0,1744092 11,267454 0,0074415 0,16489346 receptor 2 (interferon gamma transducer 1)

883 4281 MID1 midline 1 (Opitz/BBB 0,44762817 8,5116286 0,0074691 0,16495822 syndrome)

884 4594 MUT methylmalonyl CoA -0,1855884 10,077606 0,0074701 0,16495822 mutase 885 31 ACACA acetyl-CoA carboxylase -0,4991471 10,344271 0,0074812 0,16495822 alpha 886 2230 FDX1 ferredoxin 1 0,1406573 8,1260341 0,0074856 0,16495822 887 79009 DDX50 DEAD (Asp-Glu-Ala- -0,2121213 9,0479161 0,0074875 0,16495822 Asp) box polypeptide 50 888 127933 UHMK1 U2AF homology motif 0,35783988 9,1515132 0,0074977 0,16495822 (UHM) kinase 1

889 9530 BAG4 BCL2-associated -0,3429717 8,4106744 0,0075132 0,16495822 athanogene 4 890 9659 PDE4DIP phosphodiesterase 4D 0,35863697 6,0075254 0,0075192 0,16495822 interacting protein

891 11031 RAB31 RAB31, member RAS 0,35211678 9,23597 0,0075252 0,16495822 oncogene family

892 2350 FOLR2 folate receptor 2 0,93863375 7,0961843 0,0075288 0,16495822 (fetal) 893 1783 DYNC1LI2 dynein, cytoplasmic 1, 0,17191885 10,803318 0,0075541 0,16532787 light intermediate chain 2

894 57567 ZNF319 zinc finger protein 319 -0,1779842 3,7135537 0,0075739 0,16539789

895 23235 SIK2 salt-inducible kinase 2 -0,3212594 9,6226146 0,0075742 0,16539789

896 7408 VASP vasodilator-stimulated 0,21453576 7,8852908 0,0075838 0,16542105 phosphoprotein

897 5774 PTPN3 protein tyrosine -0,3612184 5,9867866 0,0076531 0,16673545 phosphatase, non- receptor type 3 898 2268 FGR feline Gardner- 0,38939317 5,304055 0,0076611 0,16673545 Rasheed sarcoma viral oncogene homolog 899 9367 RAB9A RAB9A, member RAS 0,26736364 10,402743 0,0076853 0,16707586 oncogene family

900 8445 DYRK2 dual-specificity 0,25477625 4,7394956 0,0077175 0,16742573 tyrosine-(Y)- phosphorylation regulated kinase 2 901 9424 KCNK6 potassium channel, -1,7666009 5,1847705 0,0077185 0,16742573 subfamily K, member 6

902 114780 PKD1L2 polycystic kidney -0,333341 5,2981178 0,0077575 0,16808564 disease 1-like 2 903 116228 COX20 COX20 cytochrome C 0,20294729 8,8833395 0,0077884 0,16839911 oxidase assembly factor 904 51085 MLXIPL MLX interacting -0,488991 7,5731935 0,0077892 0,16839911 protein-like 905 2888 GRB14 growth factor receptor- 0,63141152 4,9590286 0,0078016 0,16848058 bound protein 14

906 23248 RPRD2 regulation of nuclear -0,1377177 7,1808781 0,0078155 0,16859392 pre-mRNA domain containing 2 907 55020 TTC38 tetratricopeptide -0,3266126 7,6658051 0,0078269 0,16864194 repeat domain 38 908 344148 NCKAP5 NCK-associated 0,52208916 3,3288354 0,0078459 0,16864194 protein 5 909 9552 SPAG7 sperm associated -0,1504303 9,6103832 0,0078679 0,16864194 antigen 7 910 8241 RBM10 RNA binding motif -0,2978119 7,2064969 0,0078688 0,16864194 protein 10 911 7184 HSP90B1 heat shock protein 0,22858745 11,64278 0,0078691 0,16864194 90kDa beta (Grp94), member 1 912 1519 CTSO cathepsin O 0,25621361 8,1753195 0,0078695 0,16864194 913 23392 KIAA0368 KIAA0368 -0,1186341 10,357531 0,0079097 0,16931724 914 444 ASPH aspartate beta- 0,15672603 11,485447 0,0079215 0,16938529 hydroxylase 915 1027 CDKN1B cyclin-dependent -0,2354651 11,05627 0,0079362 0,16951279 kinase inhibitor 1B (p27, Kip1) 916 404672 GTF2H5 general transcription 0,12987051 3,9765569 0,0079474 0,16956841 factor IIH, polypeptide 5 917 80114 BICC1 BicC family RNA 0,60627275 6,587057 0,0079726 0,16956947 binding protein 1 918 653784 MZT2A mitotic spindle -0,2488052 8,8480388 0,0079771 0,16956947 organizing protein 2A 919 114905 C1QTNF7 C1q and tumor -0,5407252 6,7655858 0,0079795 0,16956947 necrosis factor related protein 7 920 9324 HMGN3 high mobility group -0,1383536 12,265939 0,0079905 0,16956947 nucleosomal binding domain 3 921 9749 PHACTR2 phosphatase and actin 0,20606671 8,8739325 0,0079909 0,16956947 regulator 2 922 4646 MYO6 myosin VI 0,14625235 7,5276832 0,008018 0,16970282 923 622 BDH1 3-hydroxybutyrate -0,6470633 3,1421188 0,0080271 0,16970282 dehydrogenase, type 1

924 8036 SHOC2 soc-2 suppressor of 0,15197672 10,552059 0,0080315 0,16970282 clear homolog (C. elegans) 925 7347 UCHL3 ubiquitin carboxyl- 0,2251497 9,4344096 0,0080633 0,16970282 terminal esterase L3 (ubiquitin thiolesterase) 926 11051 NUDT21 nudix (nucleoside -0,162525 7,9453019 0,0080687 0,16970282 diphosphate linked moiety X)-type motif 21 927 2631 GBAS glioblastoma amplified -0,1997781 12,360118 0,0080699 0,16970282 sequence 928 9973 CCS copper chaperone for -0,2041803 7,3313374 0,0080775 0,16970282 superoxide dismutase

929 11162 NUDT6 nudix (nucleoside -0,2063778 7,6477363 0,0080791 0,16970282 diphosphate linked moiety X)-type motif 6

930 2879 GPX4 glutathione peroxidase -0,1349872 14,563176 0,0080838 0,16970282 4 931 307 ANXA4 annexin A4 0,26841399 9,8735549 0,008084 0,16970282 932 2200 FBN1 fibrillin 1 0,38161757 10,085894 0,0081085 0,16992726 933 6749 SSRP1 structure specific -0,2262881 8,463476 0,0081121 0,16992726 recognition protein 1

934 57658 CALCOCO1 calcium binding and -0,2337597 7,7160184 0,0081213 0,16993799 coiled-coil domain 1 935 950 SCARB2 scavenger receptor 0,25557196 10,32913 0,0081406 0,17016022 class B, member 2 936 79772 MCTP1 multiple C2 domains, 0,52958601 6,5682824 0,0081754 0,17066764 transmembrane 1

937 79078 C1orf50 chromosome 1 open -0,2176971 7,3074486 0,0081893 0,17066764 reading frame 50 938 57154 SMURF1 SMAD specific E3 -0,083828 4,5997704 0,0081911 0,17066764 ubiquitin protein ligase 1 939 8625 RFXANK regulatory factor X- -0,2892525 6,4561317 0,0082119 0,17092042 associated ankyrin- containing protein 940 1794 DOCK2 dedicator of 0,54154331 3,9794297 0,0082327 0,17116983 cytokinesis 2 941 8165 AKAP1 A kinase (PRKA) anchor -0,2504675 8,2550479 0,0082421 0,17118322 protein 1 942 64601 VPS16 vacuolar protein -0,2257873 7,2102851 0,0082775 0,17160701 sorting 16 homolog (S. cerevisiae) 943 8572 PDLIM4 PDZ and LIM domain 4 0,17783274 2,8995682 0,0082801 0,17160701

944 5518 PPP2R1A protein phosphatase 2, -0,1736652 8,6995941 0,0082923 0,17167819 regulatory subunit A, alpha

945 10972 TMED10 transmembrane 0,07054629 11,202851 0,0083097 0,17185746 emp24-like trafficking protein 10 (yeast)

946 54431 DNAJC10 DnaJ (Hsp40) homolog, 0,32551138 7,2454957 0,0083205 0,17189842 subfamily C, member 10 947 100287616 LOXL1-AS1 LOXL1 antisense RNA 1 0,68600412 4,5322212 0,0083377 0,17207207

948 221687 RNF182 ring finger protein 182 0,82403123 4,3352274 0,0084378 0,1737972

949 79705 LRRK1 leucine-rich repeat 0,47357833 3,9867563 0,0084391 0,1737972 kinase 1 950 54842 MFSD6 major facilitator 0,41780627 6,5429279 0,0084806 0,17446928 superfamily domain containing 6 951 84861 KLHL22 kelch-like family -0,2717513 6,1394199 0,0084917 0,17451227 member 22 952 8233 ZRSR2 zinc finger (CCCH -0,1858904 5,8981594 0,0085086 0,17467742 type), RNA-binding motif and serine/arginine rich 2

953 29882 ANAPC2 anaphase promoting -0,1391081 2,729867 0,0085229 0,17478612 complex subunit 2

954 54874 FNBP1L formin binding protein -0,1788641 9,8975554 0,0085328 0,17480694 1-like 955 54665 RSBN1 round spermatid basic -0,1489454 7,8473999 0,008552 0,17489212 protein 1 956 8683 SRSF9 serine/arginine-rich -0,0686045 11,771754 0,0085549 0,17489212 splicing factor 9 957 84984 CEP19 centrosomal protein 0,13685505 3,4578532 0,0085856 0,17494529 19kDa 958 800 CALD1 caldesmon 1 0,43469705 10,620148 0,0085914 0,17494529 959 51065 RPS27L ribosomal protein S27- 0,15895054 7,9066814 0,0085929 0,17494529 like 960 8850 KAT2B K(lysine) 0,16404842 10,597484 0,0086034 0,17494529 acetyltransferase 2B 961 85028 SNHG12 small nucleolar RNA -0,3516436 7,4663859 0,0086061 0,17494529 host gene 12 (non- protein coding) 962 147991 DPY19L3 dpy-19-like 3 (C. 0,16900993 8,0219823 0,0086152 0,17494529 elegans) 963 5728 PTEN phosphatase and -0,3521157 10,128427 0,0086202 0,17494529 tensin homolog 964 2124 EVI2B ecotropic viral 0,86507078 4,4173194 0,0086627 0,1756262 integration site 2B 965 2043 EPHA4 EPH receptor A4 0,17871066 3,0135181 0,0086792 0,17572177 966 26610 ELP4 elongator -0,1771503 7,9032285 0,0086926 0,17572177 acetyltransferase complex subunit 4 967 29796 UQCR10 ubiquinol-cytochrome -0,1596957 8,2966269 0,0086944 0,17572177 c reductase, complex III subunit X

968 8869 ST3GAL5 ST3 beta-galactoside 0,22104548 6,477664 0,0087287 0,17623275 alpha-2,3- sialyltransferase 5

969 83666 PARP9 poly (ADP-ribose) 0,27401113 5,7091198 0,0087406 0,17629042 polymerase family, member 9 970 117143 TADA1 transcriptional adaptor -0,280509 5,8181669 0,0087601 0,17650283 1 971 54414 SIAE sialic acid 0,30168152 7,2815746 0,0087957 0,17695302 acetylesterase 972 2359 FPR3 formyl peptide 0,8257534 3,1701743 0,0088233 0,17695302 receptor 3 973 3836 KPNA1 karyopherin alpha 1 0,18756969 7,8716148 0,0088238 0,17695302 (importin alpha 5) 974 26084 ARHGEF26 Rho guanine -0,832485 5,420503 0,0088263 0,17695302 nucleotide exchange factor (GEF) 26

975 11196 SEC23IP SEC23 interacting 0,07393636 6,9695737 0,0088326 0,17695302 protein 976 51138 COPS4 COP9 signalosome -0,0916472 10,548022 0,0088388 0,17695302 subunit 4 977 1891 ECH1 enoyl CoA hydratase 1, -0,1565056 12,925032 0,0088458 0,17695302 peroxisomal

978 8398 PLA2G6 phospholipase A2, -0,0916155 4,8003479 0,0088735 0,17728954 group VI (cytosolic, calcium-independent)

979 1890 TYMP thymidine 0,55859881 7,0888107 0,0088808 0,17728954 phosphorylase 980 137872 ADHFE1 alcohol -0,409669 8,2250519 0,008916 0,17781073 dehydrogenase, iron containing, 1 981 55324 ABCF3 ATP-binding cassette, -0,1726401 5,479698 0,0089469 0,17820484 sub-family F (GCN20), member 3

982 4217 MAP3K5 mitogen-activated -0,6690467 9,6767216 0,0089647 0,17820484 protein kinase kinase kinase 5 983 79017 GGCT gamma- -0,332046 10,46859 0,0089716 0,17820484 glutamylcyclotransfera se 984 147694 ZNF548 zinc finger protein 548 -0,0808895 4,0213809 0,0089722 0,17820484

985 5230 PGK1 phosphoglycerate 0,15057152 10,955573 0,0089989 0,17827662 kinase 1 986 91300 R3HDM4 R3H domain 0,0865427 6,7526238 0,0090085 0,17827662 containing 4 987 100188893 TOMM6 translocase of outer -0,0920673 11,959223 0,0090209 0,17827662 mitochondrial membrane 6 homolog (yeast) 988 11221 DUSP10 dual specificity 0,41681356 7,5675615 0,0090249 0,17827662 phosphatase 10 989 84988 PPP1R16A protein phosphatase 1, -0,564635 8,1398092 0,0090277 0,17827662 regulatory subunit 16A

990 8801 SUCLG2 succinate-CoA ligase, -0,1922474 11,287314 0,0090306 0,17827662 GDP-forming, beta subunit

991 10391 CORO2B coronin, actin binding -0,4745383 7,2284996 0,0090535 0,1784011 protein, 2B 992 55161 TMEM33 transmembrane 0,1502131 6,6460873 0,0090569 0,1784011 protein 33 993 259230 SGMS1 sphingomyelin 0,20571903 9,7419973 0,0090704 0,1784011 synthase 1 994 8202 NCOA3 nuclear receptor 0,21820882 6,1918647 0,0090845 0,1784011 coactivator 3 995 4121 MAN1A1 mannosidase, alpha, 0,28731982 11,052496 0,0090886 0,1784011 class 1A, member 1

996 5996 RGS1 regulator of G-protein 1,16708232 5,1041498 0,0090969 0,1784011 signaling 1 997 5701 PSMC2 proteasome (prosome, 0,17399435 8,4567511 0,0091008 0,1784011 macropain) 26S subunit, ATPase, 2

998 23478 SEC11A SEC11 homolog A (S. -0,0794728 12,711139 0,0091483 0,17905371 cerevisiae) 999 64419 MTMR14 myotubularin related -0,2511247 7,4598225 0,0091524 0,17905371 protein 14 1000 55837 EAPP E2F-associated -0,1352195 9,8292463 0,0091714 0,17909865 phosphoprotein 1001 4191 MDH2 malate dehydrogenase -0,2074674 10,498354 0,009173 0,17909865 2, NAD (mitochondrial)

1002 5305 PIP4K2A phosphatidylinositol-5- 0,13889014 6,4310599 0,0092247 0,1793874 phosphate 4-kinase, type II, alpha

1003 80176 SPSB1 splA/ryanodine -0,2434984 8,0814252 0,0092253 0,1793874 receptor domain and SOCS box containing 1

1004 132671 SPATA18 spermatogenesis 0,32181275 5,2187482 0,0092372 0,1793874 associated 18 1005 35 ACADS acyl-CoA -0,25036 8,9334812 0,0092473 0,1793874 dehydrogenase, C-2 to C-3 short chain 1006 23179 RGL1 ral guanine nucleotide 0,4044062 8,655005 0,0092531 0,1793874 dissociation stimulator- like 1

1007 7167 TPI1 triosephosphate -0,1714142 10,944174 0,0092556 0,1793874 isomerase 1 1008 27247 NFU1 NFU1 iron-sulfur -0,1517064 11,661742 0,0092659 0,1793874 cluster scaffold homolog (S. cerevisiae)

1009 7745 ZKSCAN8 zinc finger with KRAB -0,0232826 2,5866497 0,0092809 0,1793874 and SCAN domains 8

1010 3162 HMOX1 heme oxygenase 0,42817921 8,6802563 0,0092844 0,1793874 (decycling) 1 1011 1265 CNN2 calponin 2 -0,2072122 7,7194694 0,0092874 0,1793874 1012 10184 LHFPL2 lipoma HMGIC fusion 0,34643829 7,3981451 0,0092979 0,1793874 partner-like 2

1013 3434 IFIT1 interferon-induced 0,46144601 9,314831 0,009298 0,1793874 protein with tetratricopeptide repeats 1 1014 10020 GNE glucosamine (UDP-N- -0,1919011 9,8700828 0,0093374 0,17981368 acetyl)-2-epimerase/N- acetylmannosamine kinase

1015 124 ADH1A alcohol dehydrogenase -0,2876399 3,9291237 0,0093385 0,17981368 1A (class I), alpha polypeptide

1016 60598 KCNK15 potassium channel, 0,66920018 4,251662 0,0093636 0,18003192 subfamily K, member 15 1017 10026 PIGK phosphatidylinositol 0,2418659 8,6246869 0,0093682 0,18003192 glycan anchor biosynthesis, class K 1018 10201 NME6 NME/NM23 -0,4107851 6,3744027 0,0094053 0,1804966 nucleoside diphosphate kinase 6

1019 10462 CLEC10A C-type lectin domain 0,61411077 4,056874 0,0094119 0,1804966 family 10, member A

1020 60682 SMAP1 small ArfGAP 1 -0,1093108 10,091215 0,0094274 0,1804966 1021 10015 PDCD6IP programmed cell 0,10883003 10,320477 0,0094373 0,1804966 death 6 interacting protein 1022 4147 MATN2 matrilin 2 -0,2671235 11,079335 0,0094386 0,1804966 1023 9213 XPR1 xenotropic and 0,25229262 6,8038428 0,0094645 0,18065324 polytropic retrovirus receptor 1

1024 9639 ARHGEF10 Rho guanine 0,21753558 8,7284148 0,0094653 0,18065324 nucleotide exchange factor (GEF) 10

1025 54947 LPCAT2 lysophosphatidylcholin 0,3766567 4,118787 0,0095181 0,18135122 e acyltransferase 2

1026 53346 TM6SF1 transmembrane 6 0,53208144 4,5916245 0,0095296 0,18135122 superfamily member 1 1027 7077 TIMP2 TIMP metallopeptidase 0,23607762 11,828928 0,0095297 0,18135122 inhibitor 2

1028 57150 SMIM8 small integral -0,0877955 4,5618709 0,0095723 0,18198564 membrane protein 8

1029 116840 CNTROB centrobin, -0,0979938 3,8815085 0,0095975 0,18228664 centrosomal BRCA2 interacting protein 1030 221981 THSD7A thrombospondin, type 0,3456622 4,1967294 0,0096186 0,1825102 I, domain containing 7A 1031 92714 ARRDC1 arrestin domain -0,2861192 5,0046162 0,009629 0,18253087 containing 1 1032 83938 C10orf11 chromosome 10 open 0,24939338 7,6382251 0,0096668 0,18299777 reading frame 11

1033 10193 RNF41 ring finger protein 41 -0,2068415 7,5375023 0,0096724 0,18299777

1034 10130 PDIA6 protein disulfide 0,15481953 10,456919 0,0096861 0,18308132 isomerase family A, member 6 1035 23401 FRAT2 frequently rearranged -0,2102115 5,7180339 0,0097311 0,18365563 in advanced T-cell lymphomas 2

1036 5833 PCYT2 phosphate -0,4195691 5,205746 0,0097409 0,18365563 cytidylyltransferase 2, ethanolamine 1037 4048 LTA4H leukotriene A4 -0,1379519 10,568674 0,0097572 0,18365563 hydrolase 1038 84232 MAF1 MAF1 homolog (S. -0,2811195 8,1810833 0,0097617 0,18365563 cerevisiae) 1039 253512 SLC25A30 solute carrier family 0,08278821 2,5001957 0,0097678 0,18365563 25, member 30 1040 25796 PGLS 6- -0,24607 9,3878312 0,0097729 0,18365563 phosphogluconolacton ase 1041 80209 PROSER1 proline and serine rich 0,06699781 7,0937792 0,009796 0,18371905 1 1042 6839 SUV39H1 suppressor of -0,1969867 3,6018879 0,0098142 0,18371905 variegation 3-9 homolog 1 (Drosophila) 1043 10109 ARPC2 actin related protein 0,1215736 12,406368 0,0098234 0,18371905 2/3 complex, subunit 2, 34kDa

1044 79828 METTL8 methyltransferase like 0,16696036 5,8024749 0,0098299 0,18371905 8 1045 219833 C11orf45 chromosome 11 open 0,29560606 2,3470367 0,00983 0,18371905 reading frame 45

1046 9852 EPM2AIP1 EPM2A (laforin) -0,1077097 7,0425787 0,0098327 0,18371905 interacting protein 1

1047 2870 GRK6 G protein-coupled -0,1387257 5,9457913 0,0098459 0,18378954 receptor kinase 6 1048 10424 PGRMC2 progesterone receptor 0,17128005 12,27401 0,0098579 0,18383828 membrane component 2 1049 23765 IL17RA interleukin 17 receptor -0,2633377 5,4359168 0,0098797 0,18406951 A 1050 83955 NACAP1 nascent-polypeptide- -0,1361745 13,694632 0,0099434 0,18491397 associated complex alpha polypeptide pseudogene 1

1051 10982 MAPRE2 microtubule- -0,3424217 6,9137465 0,0099447 0,18491397 associated protein, RP/EB family, member 2 1052 10261 IGSF6 immunoglobulin 1,04225535 3,3427919 0,009962 0,18491397 superfamily, member 6 1053 50626 CYHR1 cysteine/histidine-rich -0,1450085 6,7865235 0,009966 0,18491397 1 1054 51409 HEMK1 HemK -0,1269075 5,7831213 0,0099723 0,18491397 methyltransferase family member 1 1055 5187 PER1 period circadian clock -0,4978252 8,0310463 0,0100059 0,18536079 1 1056 5530 PPP3CA protein phosphatase 3, 0,12144332 10,263619 0,0100426 0,18556953 catalytic subunit, alpha isozyme

1057 401505 TOMM5 translocase of outer 0,10759487 10,49075 0,0100477 0,18556953 mitochondrial membrane 5 homolog (yeast) 1058 51338 MS4A4A membrane-spanning 4- 1,07709399 6,3863934 0,0100481 0,18556953 domains, subfamily A, member 4A

1059 6844 VAMP2 vesicle-associated -0,1541376 4,8265956 0,0100591 0,18556953 membrane protein 2 (synaptobrevin 2) 1060 55735 DNAJC11 DnaJ (Hsp40) homolog, -0,1616733 6,4190763 0,0100711 0,18556953 subfamily C, member 11 1061 3005 H1F0 H1 histone family, -0,3013554 9,5802906 0,0100742 0,18556953 member 0 1062 154791 C7orf55 chromosome 7 open -0,2443243 8,6037505 0,010112 0,18609184 reading frame 55

1063 51073 MRPL4 mitochondrial -0,215034 7,0837952 0,0101404 0,18625623 ribosomal protein L4

1064 1958 EGR1 early growth response -0,2122797 13,373116 0,0101554 0,18625623 1 1065 54463 FAM134B family with sequence -0,4353862 8,1693654 0,0101555 0,18625623 similarity 134, member B 1066 55846 ITFG2 integrin alpha FG-GAP -0,1574755 4,634608 0,0101591 0,18625623 repeat containing 2

1067 51164 DCTN4 dynactin 4 (p62) -0,1585074 9,8990082 0,0101993 0,18681879 1068 8087 FXR1 fragile X mental -0,1211414 6,6068856 0,0102633 0,18732966 retardation, autosomal homolog 1

1069 4891 SLC11A2 solute carrier family 11 0,210003 6,7951139 0,0102638 0,18732966 (proton-coupled divalent metal ion transporter), member 2 1070 54800 KLHL24 kelch-like family -0,2757453 8,6512206 0,010269 0,18732966 member 24 1071 5202 PFDN2 prefoldin subunit 2 -0,2054574 10,513705 0,0102746 0,18732966 1072 84681 HINT2 histidine triad -0,2433962 10,158548 0,0102751 0,18732966 nucleotide binding protein 2 1073 23499 MACF1 microtubule-actin 0,22782498 9,6540753 0,0103272 0,18810381 crosslinking factor 1 1074 9208 LRRFIP1 leucine rich repeat (in 0,2975424 9,5489239 0,0103629 0,18847323 FLII) interacting protein 1 1075 5971 RELB v-rel avian -0,2701959 3,3905648 0,010367 0,18847323 reticuloendotheliosis viral oncogene homolog B 1076 51594 NBAS neuroblastoma -0,1025873 5,2008894 0,0103927 0,18847323 amplified sequence 1077 10196 PRMT3 protein arginine 0,20853552 7,5746508 0,0103965 0,18847323 methyltransferase 3 1078 56931 DUS3L dihydrouridine -0,2034211 4,3445747 0,0103983 0,18847323 synthase 3-like (S. cerevisiae) 1079 3843 IPO5 importin 5 -0,1005147 9,8569943 0,0104054 0,18847323 1080 5793 PTPRG protein tyrosine -0,207108 8,3780706 0,0104199 0,1885607 phosphatase, receptor type, G 1081 81537 SGPP1 sphingosine-1- 0,23280203 8,5791101 0,0104364 0,18868504 phosphate phosphatase 1 1082 23014 FBXO21 F-box protein 21 -0,1398572 8,7478529 0,0104794 0,18914218 1083 6944 VPS72 vacuolar protein -0,178745 8,3702457 0,010481 0,18914218 sorting 72 homolog (S. cerevisiae) 1084 5939 RBMS2 RNA binding motif, -0,1046374 6,0926315 0,010511 0,18922439 single stranded interacting protein 2

1085 55200 PLEKHG6 pleckstrin homology -0,2911466 8,2510272 0,0105131 0,18922439 domain containing, family G (with RhoGef domain) member 6

1086 8651 SOCS1 suppressor of cytokine -0,3559904 6,4974897 0,0105214 0,18922439 signaling 1 1087 51493 RTCB RNA 2',3'-cyclic -0,1688536 9,7956446 0,0105364 0,18922439 phosphate and 5'-OH ligase 1088 114915 EPB41L4A- EPB41L4A antisense -0,3376275 10,205304 0,0105385 0,18922439 AS1 RNA 1 1089 51406 NOL7 nucleolar protein 7, -0,1491975 11,034425 0,0105514 0,18922439 27kDa 1090 22907 DHX30 DEAH (Asp-Glu-Ala-His) -0,1264216 6,0881541 0,0105533 0,18922439 box helicase 30 1091 64978 MRPL38 mitochondrial -0,2930114 7,0569529 0,0105737 0,18927299 ribosomal protein L38

1092 114614 MIR155HG MIR155 host gene 1,31875031 6,7663343 0,0105754 0,18927299 (non-protein coding)

1093 10655 DMRT2 doublesex and mab-3 -0,4240792 9,5615612 0,0106168 0,18983961 related transcription factor 2

1094 23048 FNBP1 formin binding protein 0,13715135 6,5019937 0,0106445 0,18997236 1 1095 55106 SLFN12 schlafen family 0,45373789 3,4353375 0,0106558 0,18997236 member 12 1096 25800 SLC39A6 solute carrier family 39 0,2421513 8,0537815 0,010664 0,18997236 (zinc transporter), member 6 1097 5018 OXA1L oxidase (cytochrome c) -0,2259697 10,520844 0,0106703 0,18997236 assembly 1-like

1098 133584 EGFLAM EGF-like, fibronectin -0,595146 8,1294075 0,0106728 0,18997236 type III and laminin G domains

1099 114971 PTPMT1 protein tyrosine -0,1647904 7,8399737 0,0106845 0,19000754 phosphatase, mitochondrial 1 1100 55008 HERC6 HECT and RLD domain 0,75703568 4,4552219 0,0107204 0,19027719 containing E3 ubiquitin protein ligase family member 6

1101 4258 MGST2 microsomal -0,1678017 10,126069 0,0107303 0,19027719 glutathione S- transferase 2 1102 26953 RANBP6 RAN binding protein 6 0,20123627 9,320797 0,01074 0,19027719

1103 4716 NDUFB10 NADH dehydrogenase -0,1936693 11,453826 0,0107472 0,19027719 (ubiquinone) 1 beta subcomplex, 10, 22kDa

1104 56889 TM9SF3 transmembrane 9 0,15080494 10,875542 0,0107484 0,19027719 superfamily member 3

1105 3059 HCLS1 hematopoietic cell- 0,52364446 6,9072453 0,010816 0,19130087 specific Lyn substrate 1

1106 5432 POLR2C polymerase (RNA) II -0,1399216 8,8180325 0,0108372 0,19150338 (DNA directed) polypeptide C, 33kDa

1107 5139 PDE3A phosphodiesterase 3A, -0,3103755 4,7842408 0,0108684 0,19173525 cGMP-inhibited 1108 401115 C4orf48 chromosome 4 open 0,32318821 8,061126 0,0108746 0,19173525 reading frame 48

1109 7436 VLDLR very low density 0,40173058 11,680331 0,0108824 0,19173525 lipoprotein receptor

1110 94239 H2AFV H2A histone family, 0,14067681 10,554794 0,0109004 0,19173525 member V 1111 6168 RPL37A ribosomal protein L37a -0,1223253 14,816951 0,010912 0,19173525

1112 6304 SATB1 SATB homeobox 1 -0,2853058 8,9033223 0,0109125 0,19173525 1113 138428 PTRH1 peptidyl-tRNA -0,1680947 4,7543442 0,010919 0,19173525 hydrolase 1 homolog (S. cerevisiae)

1114 9931 HELZ helicase with zinc -0,1454001 8,8879555 0,0109425 0,19197487 finger 1115 10157 AASS aminoadipate- -0,5109357 7,2565017 0,0109734 0,1923171 semialdehyde synthase 1116 4695 NDUFA2 NADH dehydrogenase -0,0966864 10,617874 0,0109925 0,1923171 (ubiquinone) 1 alpha subcomplex, 2, 8kDa

1117 3337 DNAJB1 DnaJ (Hsp40) homolog, -0,2625331 12,358335 0,0109995 0,1923171 subfamily B, member 1

1118 10552 ARPC1A actin related protein -0,1640831 10,990073 0,0110014 0,1923171 2/3 complex, subunit 1A, 41kDa

1119 51020 HDDC2 HD domain containing -0,1681377 8,4186326 0,0110317 0,19261528 2 1120 124565 SLC38A10 solute carrier family 0,13613803 4,1256754 0,0110499 0,19261528 38, member 10 1121 23258 DENND5A DENN/MADD domain 0,1562264 10,649344 0,0110565 0,19261528 containing 5A

1122 1831 TSC22D3 TSC22 domain family, -0,2587911 10,763976 0,0110578 0,19261528 member 3 1123 4664 NAB1 NGFI-A binding protein 0,22294273 9,0824664 0,0110785 0,19271969 1 (EGR1 binding protein 1) 1124 64400 AKTIP AKT interacting protein 0,16720875 9,7155766 0,0110864 0,19271969

1125 214 ALCAM activated leukocyte 0,52050518 4,7966777 0,0110934 0,19271969 cell adhesion molecule

1126 3251 HPRT1 hypoxanthine 0,22588778 8,4244864 0,0111292 0,19306529 phosphoribosyltransfe rase 1 1127 10288 LILRB2 leukocyte 0,61876661 2,9191664 0,0111331 0,19306529 immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2

1128 10742 RAI2 retinoic acid induced 2 -0,5467516 9,4536109 0,0111912 0,19385009 1129 1398 CRK v-crk avian sarcoma 0,11216727 9,956762 0,0112135 0,19385009 virus CT10 oncogene homolog 1130 57291 DANCR differentiation -0,2954768 7,5864443 0,0112227 0,19385009 antagonizing non- protein coding RNA 1131 6281 S100A10 S100 calcium binding 0,18215655 14,259594 0,0112347 0,19385009 protein A10 1132 1307 COL16A1 collagen, type XVI, 0,46806456 6,5973808 0,0112403 0,19385009 alpha 1 1133 6102 RP2 retinitis pigmentosa 2 0,39605815 8,9980838 0,011249 0,19385009 (X-linked recessive)

1134 57526 PCDH19 protocadherin 19 0,2123707 7,6297732 0,0112491 0,19385009 1135 85379 KIAA1671 KIAA1671 0,22552472 3,5396389 0,0112577 0,19385009 1136 463 ZFHX3 zinc finger homeobox 0,15923776 5,5822166 0,0112801 0,19406532 3 1137 873 CBR1 carbonyl reductase 1 0,26527333 8,3886022 0,011319 0,19454742

1138 5737 PTGFR prostaglandin F 0,6266839 2,5272214 0,0113606 0,19454742 receptor (FP) 1139 54873 PALMD palmdelphin 0,18764196 12,508414 0,011367 0,19454742 1140 962 CD48 CD48 molecule 0,81750352 4,6051084 0,0113705 0,19454742 1141 10627 MYL12A myosin, light chain 0,16200481 13,106919 0,0113778 0,19454742 12A, regulatory, non- sarcomeric 1142 1345 COX6C cytochrome c oxidase -0,119862 13,365196 0,0113812 0,19454742 subunit VIc 1143 10541 ANP32B acidic (leucine-rich) -0,1510975 12,331071 0,0113887 0,19454742 nuclear phosphoprotein 32 family, member B 1144 200933 FBXO45 F-box protein 45 0,05006524 4,0244942 0,0114094 0,19454742 1145 51497 NELFCD negative elongation -0,1687422 8,6686875 0,0114295 0,19454742 factor complex member C/D 1146 51061 TXNDC11 thioredoxin domain -0,2178532 6,8024406 0,0114305 0,19454742 containing 11 1147 57546 PDP2 pyruvate -0,2787127 7,3306311 0,011437 0,19454742 dehyrogenase phosphatase catalytic subunit 2 1148 23132 RAD54L2 RAD54-like 2 (S. -0,2933057 5,2473566 0,0114387 0,19454742 cerevisiae) 1149 254863 TMEM256 transmembrane -0,2164618 9,4908731 0,011445 0,19454742 protein 256 1150 23406 COTL1 coactosin-like F-actin 0,3648401 9,729487 0,0114555 0,19454742 binding protein 1 1151 84337 ELOF1 elongation factor 1 -0,2523759 7,3220148 0,0114645 0,19454742 homolog (S. cerevisiae)

1152 100507567 RAB11B- RAB11B antisense RNA -0,2298434 6,1018573 0,0114674 0,19454742 AS1 1 1153 9630 GNA14 guanine nucleotide -0,5516631 6,9484986 0,0114831 0,1946452 binding protein (G protein), alpha 14 1154 65095 KRI1 KRI1 homolog (S. -0,1668823 3,5584363 0,0115024 0,19466478 cerevisiae) 1155 2768 GNA12 guanine nucleotide 0,19096414 8,4399285 0,0115042 0,19466478 binding protein (G protein) alpha 12 1156 5528 PPP2R5D protein phosphatase 2, -0,1858865 7,2491445 0,0115207 0,194759 regulatory subunit B', delta

1157 55260 TMEM143 transmembrane -0,2161621 5,2427266 0,0115297 0,194759 protein 143 1158 11279 KLF8 Kruppel-like factor 8 -0,1585346 7,0182657 0,0115535 0,19487856

1159 11080 DNAJB4 DnaJ (Hsp40) homolog, 0,20571304 10,394998 0,0115567 0,19487856 subfamily B, member 4

1160 11275 KLHL2 kelch-like family 0,19187192 9,6220804 0,0116206 0,1957155 member 2 1161 6091 ROBO1 roundabout, axon -0,1524388 10,887956 0,0116264 0,1957155 guidance receptor, homolog 1 (Drosophila) 1162 287 ANK2 ankyrin 2, neuronal -0,6995894 9,1057705 0,0116423 0,19580835 1163 129787 TMEM18 transmembrane -0,1676306 7,4565102 0,011656 0,19580835 protein 18 1164 151903 CCDC12 coiled-coil domain -0,1559738 8,9565013 0,0116681 0,19580835 containing 12 1165 6277 S100A6 S100 calcium binding 0,18410402 13,534854 0,011672 0,19580835 protein A6 1166 79752 ZFAND1 zinc finger, AN1-type -0,202674 9,6395906 0,0116898 0,19594027 domain 1 1167 100652853 LINC01023 long intergenic non- -0,3379766 4,533355 0,01173 0,19644434 protein coding RNA 1023 1168 79675 FASTKD1 FAST kinase domains 1 0,28477473 8,6895935 0,0117828 0,19698128

1169 27336 HTATSF1 HIV-1 Tat specific 0,12320344 8,9379482 0,0117855 0,19698128 factor 1 1170 91801 ALKBH8 alkB, alkylation repair 0,17283732 4,1446975 0,0117923 0,19698128 homolog 8 (E. coli) 1171 7301 TYRO3 TYRO3 protein tyrosine -0,1703143 7,0288874 0,0118241 0,19705864 kinase 1172 2644 GCHFR GTP cyclohydrolase I -0,4515659 8,3323757 0,0118349 0,19705864 feedback regulator 1173 961 CD47 CD47 molecule 0,17817161 7,6147523 0,0118359 0,19705864 1174 5788 PTPRC protein tyrosine 0,28582753 3,1991165 0,0118372 0,19705864 phosphatase, receptor type, C 1175 80273 GRPEL1 GrpE-like 1, -0,1577305 8,6444947 0,011873 0,19748573 mitochondrial (E. coli)

1176 56731 SLC2A4RG SLC2A4 regulator -0,266121 7,6251194 0,011898 0,19767589

1177 4139 MARK1 MAP/microtubule 0,2549399 8,0103436 0,0119118 0,19767589 affinity-regulating kinase 1 1178 93134 ZNF561 zinc finger protein 561 -0,2627363 4,0876528 0,0119228 0,19767589

1179 407026 MIR29C microRNA 29c -0,8011431 3,665981 0,0119427 0,19767589 1180 51634 RBMX2 RNA binding motif -0,1717274 7,5709296 0,0119546 0,19767589 protein, X-linked 2 1181 6015 RING1 ring finger protein 1 -0,1680491 8,6615812 0,0119695 0,19767589 1182 3553 IL1B interleukin 1, beta 1,01957046 10,375913 0,0119733 0,19767589 1183 3745 KCNB1 potassium voltage- 0,37654668 8,5800734 0,0119788 0,19767589 gated channel, Shab- related subfamily, member 1 1184 29072 SETD2 SET domain containing -0,1160188 7,7225811 0,011994 0,19767589 2 1185 4239 MFAP4 microfibrillar- 0,92652482 8,6678927 0,0119969 0,19767589 associated protein 4 1186 51447 IP6K2 inositol -0,1523859 6,445907 0,0120039 0,19767589 hexakisphosphate kinase 2 1187 283638 CEP170B centrosomal protein 0,18551787 6,5216283 0,0120058 0,19767589 170B 1188 8655 DYNLL1 dynein, light chain, LC8- 0,15354978 14,359394 0,0120587 0,19826108 type 1 1189 1462 VCAN versican 1,04084985 6,5238315 0,0120763 0,19826108 1190 3182 HNRNPAB heterogeneous nuclear 0,13341294 10,945149 0,0120804 0,19826108 ribonucleoprotein A/B

1191 27130 INVS inversin 0,09144977 7,4154316 0,0120819 0,19826108 1192 63894 VIPAS39 VPS33B interacting -0,2063495 5,1374599 0,0121065 0,19849854 protein, apical- basolateral polarity regulator, spe-39 homolog 1193 25927 CNRIP1 cannabinoid receptor -0,1886858 11,018952 0,0121664 0,19912554 interacting protein 1

1194 23774 BRD1 bromodomain -0,1263313 7,9958635 0,0121748 0,19912554 containing 1 1195 498 ATP5A1 ATP synthase, H+ -0,0789747 13,972141 0,0121753 0,19912554 transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle

1196 252969 NEIL2 nei endonuclease VIII- 0,31974146 8,3948572 0,0122076 0,19929542 like 2 (E. coli) 1197 4221 MEN1 multiple endocrine -0,3639774 4,1818378 0,0122201 0,19929542 neoplasia I 1198 9488 PIGB phosphatidylinositol 0,16376309 8,0227471 0,0122255 0,19929542 glycan anchor biosynthesis, class B 1199 55589 BMP2K BMP2 inducible kinase 0,20928223 5,9597446 0,012228 0,19929542

1200 440275 EIF2AK4 eukaryotic translation 0,13871966 8,7309682 0,0122557 0,19929542 initiation factor 2 alpha kinase 4

1201 6601 SMARCC2 SWI/SNF related, -0,2601306 9,0297756 0,0122572 0,19929542 matrix associated, actin dependent regulator of chromatin, subfamily c, member 2

1202 10252 SPRY1 sprouty homolog 1, 0,27649284 10,282197 0,0122703 0,19929542 antagonist of FGF signaling (Drosophila)

1203 9477 MED20 mediator complex 0,14065776 3,9451658 0,0122778 0,19929542 subunit 20 1204 10672 GNA13 guanine nucleotide 0,17558302 9,4140676 0,0122852 0,19929542 binding protein (G protein), alpha 13 1205 4931 NVL nuclear VCP-like -0,0891808 4,6047678 0,0122877 0,19929542 1206 90637 ZFAND2A zinc finger, AN1-type -0,1814169 8,708553 0,0123199 0,19944672 domain 2A 1207 8566 PDXK pyridoxal (pyridoxine, -0,1793215 9,2704712 0,0123219 0,19944672 vitamin B6) kinase 1208 123096 SLC25A29 solute carrier family 25 -0,1130623 3,0030398 0,0123366 0,19944672 (mitochondrial carnitine/acylcarnitine carrier), member 29

1209 55902 ACSS2 acyl-CoA synthetase -0,4412056 11,48866 0,0123379 0,19944672 short-chain family member 2 1210 28972 SPCS1 signal peptidase -0,0913932 12,051477 0,0123592 0,19962682 complex subunit 1 homolog (S. cerevisiae)

1211 8604 SLC25A12 solute carrier family 25 0,17366543 6,8783006 0,0123784 0,19977204 (aspartate/glutamate carrier), member 12

1212 79002 C19orf43 chromosome 19 open -0,1439877 11,485804 0,0124176 0,20023954 reading frame 43

1213 3552 IL1A interleukin 1, alpha 1,30565364 5,7067976 0,0124474 0,20041612 1214 2919 CXCL1 chemokine (C-X-C 0,83714223 8,7225153 0,0124491 0,20041612 motif) ligand 1 (melanoma growth stimulating activity, alpha) 1215 22955 SCMH1 sex comb on midleg -0,2334589 6,5159057 0,0124602 0,20042996 homolog 1 (Drosophila) 1216 10194 TSHZ1 teashirt zinc finger 0,17579522 7,7879272 0,0124824 0,20062124 homeobox 1 1217 349565 NMNAT3 nicotinamide -0,2088419 6,5695697 0,0125105 0,20090737 nucleotide adenylyltransferase 3

1218 10269 ZMPSTE24 zinc metallopeptidase 0,16284111 10,172293 0,012553 0,20142049 STE24

1219 662 BNIP1 BCL2/adenovirus E1B -0,2559291 5,9770964 0,0125676 0,20142049 19kDa interacting protein 1

1220 10657 KHDRBS1 KH domain containing, -0,1307979 9,7757395 0,0125826 0,20142049 RNA binding, signal transduction associated 1

1221 1456 CSNK1G3 casein kinase 1, 0,10907269 8,7817982 0,0125836 0,20142049 gamma 3 1222 2975 GTF3C1 general transcription -0,1470093 6,2416736 0,0126314 0,2020195 factor IIIC, polypeptide 1, alpha 220kDa

1223 146556 C16orf89 chromosome 16 open -0,5868464 6,8505904 0,0126609 0,20232645 reading frame 89

1224 5496 PPM1G protein phosphatase, -0,1334689 8,0348804 0,012675 0,20238537 Mg2+/Mn2+ dependent, 1G

1225 11070 TMEM115 transmembrane -0,2003953 6,7376595 0,0127188 0,20291958 protein 115 1226 4236 MFAP1 microfibrillar- 0,14188885 8,4030818 0,0127407 0,20292887 associated protein 1 1227 23481 PES1 pescadillo ribosomal -0,102161 6,8571442 0,0127509 0,20292887 biogenesis factor 1

1228 83862 TMEM120 transmembrane -0,3339176 9,3886564 0,0127581 0,20292887 A protein 120A 1229 9841 ZBTB24 zinc finger and BTB -0,2920608 5,0805269 0,0127628 0,20292887 domain containing 24

1230 5609 MAP2K7 mitogen-activated -0,0965545 4,3728838 0,0127775 0,20292887 protein kinase kinase 7

1231 51650 MRPS33 mitochondrial -0,1867561 9,577494 0,0127912 0,20292887 ribosomal protein S33

1232 9509 ADAMTS2 ADAM 0,19538047 7,2058358 0,0127921 0,20292887 metallopeptidase with thrombospondin type 1 motif, 2

1233 57380 MRS2 MRS2 magnesium -0,1469764 8,9358192 0,0128151 0,2030732 transporter 1234 23150 FRMD4B FERM domain 0,89348861 6,6661664 0,012822 0,2030732 containing 4B 1235 11096 ADAMTS5 ADAM 0,28496122 9,3379855 0,0128845 0,20389832 metallopeptidase with thrombospondin type 1 motif, 5

1236 5910 RAP1GDS1 RAP1, GTP-GDP -0,0948626 8,3701419 0,0129328 0,20434162 dissociation stimulator 1 1237 27346 TMEM97 transmembrane -0,2999184 3,8358981 0,0129334 0,20434162 protein 97 1238 29071 C1GALT1C C1GALT1-specific 0,27843654 9,3164571 0,0129575 0,20443699 1 chaperone 1 1239 221937 FOXK1 forkhead box K1 -0,033986 6,1270037 0,0129604 0,20443699 1240 114548 NLRP3 NLR family, pyrin 0,59428119 2,8506397 0,0130244 0,20528198 domain containing 3 1241 8439 NSMAF neutral 0,11254159 7,1949763 0,0130459 0,20545454 sphingomyelinase (N- SMase) activation associated factor

1242 10494 STK25 serine/threonine -0,2042615 7,8027418 0,0131094 0,20616302 kinase 25 1243 22980 TCF25 transcription factor 25 -0,1383129 9,4326979 0,013115 0,20616302 (basic helix-loop-helix)

1244 11261 CHP1 calcineurin-like EF- -0,2963673 11,058476 0,0131225 0,20616302 hand protein 1 1245 492311 IGIP IgA-inducing protein 0,19184565 7,3083993 0,0131394 0,20626202

1246 25939 SAMHD1 SAM domain and HD 0,53006673 6,3958433 0,0131504 0,20626979 domain 1 1247 3587 IL10RA interleukin 10 1,02575622 5,8624632 0,0131703 0,20641538 receptor, alpha 1248 24138 IFIT5 interferon-induced 0,23745923 7,8157237 0,0132323 0,20692937 protein with tetratricopeptide repeats 5 1249 4715 NDUFB9 NADH dehydrogenase -0,1511132 11,609211 0,0132357 0,20692937 (ubiquinone) 1 beta subcomplex, 9, 22kDa

1250 401466 C8orf59 chromosome 8 open -0,1910569 9,4944559 0,0132422 0,20692937 reading frame 59

1251 541468 LURAP1 leucine rich adaptor -0,2210195 3,9061438 0,0132454 0,20692937 protein 1 1252 83642 SELO selenoprotein O -0,1622184 7,2645386 0,0132742 0,20710244 1253 125488 TTC39C tetratricopeptide -0,2664871 7,0666658 0,0132777 0,20710244 repeat domain 39C 1254 57102 C12orf4 chromosome 12 open 0,18404268 6,9623045 0,0132993 0,2071119 reading frame 4

1255 8402 SLC25A11 solute carrier family 25 -0,1747187 7,7713462 0,0132995 0,2071119 (mitochondrial carrier; oxoglutarate carrier), member 11

1256 51527 GSKIP GSK3B interacting 0,19677877 9,3793873 0,013334 0,20748358 protein 1257 201626 PDE12 phosphodiesterase 12 0,14341599 8,3749596 0,0134191 0,20864114 1258 26260 FBXO25 F-box protein 25 -0,1698505 8,3838019 0,0134628 0,2090578 1259 50862 RNF141 ring finger protein 141 0,24248491 10,241877 0,0134672 0,2090578

1260 2821 GPI glucose-6-phosphate -0,1737352 11,268983 0,01348 0,20908957 isomerase

1261 114569 MAL2 mal, T-cell 0,28378837 10,440531 0,0134909 0,20909358 differentiation protein 2 (gene/pseudogene)

1262 1410 CRYAB crystallin, alpha B 0,25075966 14,486038 0,013545 0,20961135 1263 100507303 SNHG19 small nucleolar RNA -0,2222948 8,6426342 0,0135545 0,20961135 host gene 19 (non- protein coding) 1264 4700 NDUFA6 NADH dehydrogenase -0,1259235 9,6212814 0,0135632 0,20961135 (ubiquinone) 1 alpha subcomplex, 6, 14kDa

1265 114789 SLC25A25 solute carrier family 25 -0,2749249 10,542578 0,0135673 0,20961135 (mitochondrial carrier; phosphate carrier), member 25 1266 54508 EPB41L4A- EPB41L4A antisense -0,2623816 2,958912 0,0135926 0,20979726 AS2 RNA 2 (head to head)

1267 7570 ZNF22 zinc finger protein 22 -0,2053355 8,4855363 0,0136008 0,20979726

1268 976 CD97 CD97 molecule 0,20614742 5,5566787 0,0136462 0,21020607 1269 1912 PHC2 polyhomeotic -0,1205905 5,3046185 0,0136488 0,21020607 homolog 2 (Drosophila) 1270 25983 NGDN neuroguidin, EIF4E -0,1128531 9,306386 0,0136876 0,21063885 binding protein 1271 5054 SERPINE1 serpin peptidase 0,83691515 5,8352165 0,013742 0,2113088 inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1

1272 1892 ECHS1 enoyl CoA hydratase, -0,2220177 12,512713 0,0137699 0,21157158 short chain, 1, mitochondrial

1273 5465 PPARA peroxisome -0,2323474 5,5479032 0,0137826 0,21159973 proliferator-activated receptor alpha

1274 688 KLF5 Kruppel-like factor 5 -0,4420136 5,8919562 0,0138759 0,21274583 (intestinal) 1275 2335 FN1 fibronectin 1 0,36952104 8,5805216 0,013879 0,21274583 1276 100505483 PRKAG2- PRKAG2 antisense RNA -0,3313281 7,4669869 0,013932 0,21339183 AS1 1 1277 55146 ZDHHC4 zinc finger, DHHC-type -0,221381 8,9649711 0,0139506 0,21350926 containing 4 1278 4921 DDR2 discoidin domain 0,24885149 10,390386 0,0140387 0,21443773 receptor tyrosine kinase 2 1279 781 CACNA2D1 calcium channel, 0,29429962 10,177743 0,0140609 0,21443773 voltage-dependent, alpha 2/delta subunit 1

1280 9231 DLG5 discs, large homolog 5 -0,1509006 9,1141057 0,0140622 0,21443773 (Drosophila)

1281 55016 MARCH1 membrane-associated 0,19477827 2,4205652 0,014075 0,21443773 ring finger (C3HC4) 1, E3 ubiquitin protein ligase

1282 83786 FRMD8 FERM domain -0,103393 5,9290279 0,0140775 0,21443773 containing 8 1283 3433 IFIT2 interferon-induced 0,53439832 7,061272 0,0140817 0,21443773 protein with tetratricopeptide repeats 2 1284 8459 TPST2 tyrosylprotein 0,2806639 10,647763 0,0140881 0,21443773 sulfotransferase 2 1285 3726 JUNB jun B proto-oncogene -0,2243863 12,459394 0,014104 0,21451253

1286 4694 NDUFA1 NADH dehydrogenase -0,0771126 12,266274 0,0141155 0,21452056 (ubiquinone) 1 alpha subcomplex, 1, 7.5kDa

1287 3192 HNRNPU heterogeneous nuclear 0,08317793 7,0246352 0,0141703 0,21504485 ribonucleoprotein U (scaffold attachment factor A)

1288 2534 FYN FYN oncogene related 0,19794151 7,871083 0,0141785 0,21504485 to SRC, FGR, YES

1289 151556 GPR155 G protein-coupled 0,22266299 6,3172562 0,0141832 0,21504485 receptor 155 1290 11067 C10orf10 chromosome 10 open -0,4480405 12,327255 0,014194 0,21504485 reading frame 10 1291 10992 SF3B2 splicing factor 3b, -0,2191866 9,715963 0,0142241 0,21513903 subunit 2, 145kDa 1292 8754 ADAM9 ADAM 0,38255423 7,955292 0,014227 0,21513903 metallopeptidase domain 9 1293 26575 RGS17 regulator of G-protein -0,7580923 5,5631051 0,0142333 0,21513903 signaling 17 1294 90580 C19orf52 chromosome 19 open -0,1937815 5,980351 0,0142624 0,21532895 reading frame 52

1295 1317 SLC31A1 solute carrier family 31 0,1047142 6,8714451 0,0142679 0,21532895 (copper transporter), member 1

1296 54675 CRLS1 cardiolipin synthase 1 -0,1725797 9,3646237 0,0142925 0,2154998

1297 55255 WDR41 WD repeat domain 41 0,16866449 8,938082 0,0143012 0,2154998

1298 54521 WDR44 WD repeat domain 44 0,15307913 7,7610282 0,0143423 0,21595199

1299 8890 EIF2B4 eukaryotic translation -0,2277241 9,0284726 0,014381 0,21636793 initiation factor 2B, subunit 4 delta, 67kDa

1300 10289 EIF1B eukaryotic translation -0,1650338 12,062445 0,0143959 0,21642604 initiation factor 1B

1301 84987 COX14 cytochrome c oxidase -0,2348192 10,761172 0,01442 0,21646677 assembly homolog 14 (S. cerevisiae)

1302 5366 PMAIP1 phorbol-12-myristate- 0,77320639 8,7576177 0,0144208 0,21646677 13-acetate-induced protein 1

1303 7108 TM7SF2 transmembrane 7 -0,4752781 9,7514081 0,0144775 0,21708259 superfamily member 2

1304 25961 NUDT13 nudix (nucleoside 0,20651111 3,9644893 0,014484 0,21708259 diphosphate linked moiety X)-type motif 13 1305 25864 ABHD14A abhydrolase domain -0,199928 8,4538442 0,0145154 0,2172389 containing 14A

1306 10498 CARM1 coactivator-associated -0,1425648 6,6437155 0,0145193 0,2172389 arginine methyltransferase 1 1307 23344 ESYT1 extended -0,222483 11,146391 0,0145371 0,2172389 synaptotagmin-like protein 1 1308 55084 SOBP sine oculis binding 0,24794582 5,2989603 0,0145453 0,2172389 protein homolog (Drosophila) 1309 9056 SLC7A7 solute carrier family 7 0,28392676 2,6988442 0,0145646 0,2172389 (amino acid transporter light chain, y+L system), member 7 1310 9737 GPRASP1 G protein-coupled -0,5107175 6,4266601 0,0145713 0,2172389 receptor associated sorting protein 1 1311 60672 MIIP migration and invasion -0,2497653 4,9175848 0,0145846 0,2172389 inhibitory protein

1312 8635 RNASET2 ribonuclease T2 0,26928219 8,5438275 0,0145859 0,2172389 1313 8569 MKNK1 MAP kinase interacting -0,097528 8,9449309 0,0146077 0,2172389 serine/threonine kinase 1

1314 84259 DCUN1D5 DCN1, defective in 0,19582662 5,7867563 0,0146151 0,2172389 cullin neddylation 1, domain containing 5

1315 7295 TXN thioredoxin 0,27859863 12,455489 0,0146167 0,2172389 1316 9512 PMPCB peptidase -0,0773535 5,9845051 0,0146411 0,21727204 (mitochondrial processing) beta 1317 7284 TUFM Tu translation -0,1279547 5,5131496 0,0146412 0,21727204 elongation factor, mitochondrial 1318 832 CAPZB capping protein (actin 0,13869505 10,486589 0,014667 0,21748971 filament) muscle Z- line, beta 1319 9804 TOMM20 translocase of outer -0,1041443 12,406589 0,0146804 0,21752335 mitochondrial membrane 20 homolog (yeast) 1320 8826 IQGAP1 IQ motif containing 0,20569078 10,137006 0,01473 0,21779816 GTPase activating protein 1 1321 64087 MCCC2 methylcrotonoyl-CoA -0,2131676 8,8693081 0,0147301 0,21779816 carboxylase 2 (beta)

1322 57088 PLSCR4 phospholipid -0,2413483 11,426644 0,0147324 0,21779816 scramblase 4 1323 1352 COX10 cytochrome c oxidase -0,2351914 6,7548982 0,014752 0,21792391 assembly homolog 10 (yeast) 1324 58528 RRAGD Ras-related GTP -0,1919852 9,7616039 0,0147966 0,21818891 binding D 1325 3920 LAMP2 lysosomal-associated 0,17047942 9,7442621 0,0148178 0,21818891 membrane protein 2

1326 54926 UBE2R2 ubiquitin-conjugating -0,1380125 9,1945051 0,0148231 0,21818891 enzyme E2R 2

1327 7516 XRCC2 X-ray repair -0,4086196 4,9624462 0,0148382 0,21818891 complementing defective repair in Chinese hamster cells 2 1328 119559 SFXN4 sideroflexin 4 -0,2762351 7,4612339 0,0148398 0,21818891 1329 23474 ETHE1 ethylmalonic -0,3312467 7,2664249 0,0148477 0,21818891 encephalopathy 1 1330 2622 GAS8 growth arrest-specific -0,2801397 3,7730109 0,0148481 0,21818891 8 1331 23332 CLASP1 cytoplasmic linker -0,1601134 8,7707642 0,0148776 0,21845858 associated protein 1 1332 1102 RCBTB2 regulator of 0,17428661 9,3938435 0,0148998 0,21857289 chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2

1333 2799 GNS glucosamine (N-acetyl)- 0,21913224 11,898638 0,0149078 0,21857289 6-sulfatase 1334 100507246 SNHG16 small nucleolar RNA -0,1922334 11,026092 0,0149357 0,21881823 host gene 16 (non- protein coding) 1335 2220 FCN2 ficolin -0,8003353 4,8035871 0,0149865 0,2193974 (collagen/fibrinogen domain containing lectin) 2 1336 830 CAPZA2 capping protein (actin 0,17270811 11,612697 0,0150123 0,2194053 filament) muscle Z- line, alpha 2

1337 1647 GADD45A growth arrest and DNA- -0,3079822 12,647982 0,0150229 0,2194053 damage-inducible, alpha 1338 55729 ATF7IP activating transcription 0,08934963 9,3588508 0,0150411 0,2194053 factor 7 interacting protein 1339 10714 POLD3 polymerase (DNA- -0,2055758 6,8998221 0,0150421 0,2194053 directed), delta 3, accessory subunit 1340 11176 BAZ2A bromodomain -0,082062 4,6324661 0,0150431 0,2194053 adjacent to zinc finger domain, 2A 1341 7124 TNF tumor necrosis factor 1,28104309 6,3163053 0,0150783 0,21967491

1342 84335 AKT1S1 AKT1 substrate 1 -0,1356629 5,8452652 0,0150933 0,21967491 (proline-rich) 1343 241 ALOX5AP arachidonate 5- 0,6804159 7,3057936 0,0151014 0,21967491 lipoxygenase- activating protein 1344 7319 UBE2A ubiquitin-conjugating 0,126108 10,958949 0,0151142 0,21967491 enzyme E2A

1345 5500 PPP1CB protein phosphatase 1, 0,15450876 10,734301 0,0151178 0,21967491 catalytic subunit, beta isozyme

1346 55109 AGGF1 angiogenic factor with 0,14547231 8,277649 0,015145 0,21972114 G patch and FHA domains 1 1347 55884 WSB2 WD repeat and SOCS 0,15413684 10,928341 0,0151583 0,21972114 box containing 2

1348 116984 ARAP2 ArfGAP with RhoGAP 0,71550616 3,5774895 0,0151722 0,21972114 domain, ankyrin repeat and PH domain 2 1349 9337 CNOT8 CCR4-NOT 0,2135333 9,3807384 0,0151745 0,21972114 transcription complex, subunit 8 1350 4799 NFX1 nuclear transcription -0,064446 4,0340689 0,0151772 0,21972114 factor, X-box binding 1

1351 23371 TENC1 tensin like C1 domain -0,3117456 9,341919 0,0152054 0,21996659 containing phosphatase (tensin 2)

1352 59342 SCPEP1 serine 0,22728732 8,9046896 0,0152638 0,22064795 carboxypeptidase 1 1353 5096 PCCB propionyl CoA -0,316769 9,3569639 0,0153756 0,22190994 carboxylase, beta polypeptide 1354 10480 EIF3M eukaryotic translation -0,1558363 11,91083 0,0153853 0,22190994 initiation factor 3, subunit M 1355 582 BBS1 Bardet-Biedl syndrome -0,0858941 6,0841276 0,015393 0,22190994 1 1356 54976 C20orf27 chromosome 20 open -0,2550702 7,2732734 0,0153967 0,22190994 reading frame 27

1357 7586 ZKSCAN1 zinc finger with KRAB -0,0960154 8,8598532 0,0154079 0,22190994 and SCAN domains 1

1358 6614 SIGLEC1 sialic acid binding Ig- 0,38981059 2,7251015 0,0154428 0,22209644 like lectin 1, sialoadhesin 1359 441476 C9orf173 chromosome 9 open -0,1491166 5,0435515 0,0154545 0,22209644 reading frame 173

1360 220296 HEPACAM hepatic and glial cell -0,318829 8,8326272 0,0154549 0,22209644 adhesion molecule

1361 28974 C19orf53 chromosome 19 open -0,157363 9,7699065 0,0154846 0,2223595 reading frame 53

1362 4701 NDUFA7 NADH dehydrogenase -0,1098402 7,7732906 0,0155513 0,2231532 (ubiquinone) 1 alpha subcomplex, 7, 14.5kDa

1363 8495 PPFIBP2 PTPRF interacting 0,30617924 7,2820887 0,0155754 0,22322104 protein, binding protein 2 (liprin beta 2)

1364 89795 NAV3 neuron navigator 3 0,25132767 5,4805527 0,0155789 0,22322104 1365 401320 LOC40132 uncharacterized -0,1886676 3,5605479 0,0156457 0,22401487 0 LOC401320 1366 207063 DHRSX dehydrogenase/reduct -0,1701042 4,7530455 0,015688 0,22437062 ase (SDR family) X- linked 1367 54885 TBC1D8B TBC1 domain family, 0,33774308 6,4446081 0,0156982 0,22437062 member 8B (with GRAM domain)

1368 113419 TEX261 testis expressed 261 -0,1578367 8,5377543 0,015705 0,22437062 1369 7027 TFDP1 transcription factor Dp- 0,20501051 9,0432701 0,0157293 0,22455365 1 1370 3357 HTR2B 5-hydroxytryptamine 0,74205509 2,7241183 0,0157683 0,22470804 (serotonin) receptor 2B, G protein-coupled

1371 3269 HRH1 histamine receptor H1 0,35690519 2,6876278 0,0157686 0,22470804 1372 84364 ARFGAP2 ADP-ribosylation -0,0956004 4,8785948 0,0157746 0,22470804 factor GTPase activating protein 2 1373 27236 ARFIP1 ADP-ribosylation 0,17131358 7,9959619 0,0157999 0,22475579 factor interacting protein 1 1374 26155 NOC2L nucleolar complex -0,1043759 4,8236081 0,015801 0,22475579 associated 2 homolog (S. cerevisiae)

1375 23670 TMEM2 transmembrane 0,29104213 9,4654041 0,0158384 0,22497615 protein 2 1376 3570 IL6R interleukin 6 receptor 0,23404575 6,7593122 0,0158564 0,22497615

1377 28526 TRDC T cell receptor delta -0,5614108 8,602214 0,015875 0,22497615 constant 1378 57410 SCYL1 SCY1-like 1 (S. -0,1611664 7,4815022 0,0158772 0,22497615 cerevisiae) 1379 401233 HTATSF1P HIV-1 Tat specific 0,50678235 6,2009397 0,0158783 0,22497615 2 factor 1 pseudogene 2

1380 7123 CLEC3B C-type lectin domain 0,47269112 12,655449 0,0158855 0,22497615 family 3, member B

1381 10559 SLC35A1 solute carrier family 35 0,16528147 10,000697 0,015943 0,22562613 (CMP-sialic acid transporter), member A1 1382 7018 TF transferrin -0,5648271 12,197692 0,0159549 0,2256311 1383 29968 PSAT1 phosphoserine 0,41423902 7,4660337 0,0159993 0,2260957 aminotransferase 1 1384 55638 SYBU syntabulin (syntaxin- -0,270607 8,8672741 0,0160385 0,22620262 interacting) 1385 821 CANX calnexin 0,16774718 10,704598 0,0160393 0,22620262 1386 54566 EPB41L4B erythrocyte -0,3407158 7,5300418 0,0160416 0,22620262 membrane protein band 4.1 like 4B 1387 166815 TIGD2 tigger transposable -0,2323397 6,5006477 0,0160718 0,22646561 element derived 2 1388 85015 USP45 ubiquitin specific 0,26757134 6,4414022 0,0160986 0,22667947 peptidase 45 1389 11231 SEC63 SEC63 homolog (S. 0,13806903 7,999065 0,0161343 0,22684034 cerevisiae) 1390 27342 RABGEF1 RAB guanine -0,1309251 9,3115208 0,0161432 0,22684034 nucleotide exchange factor (GEF) 1 1391 116068 LYSMD3 LysM, putative 0,17439021 8,8661976 0,016151 0,22684034 peptidoglycan-binding, domain containing 3

1392 5792 PTPRF protein tyrosine -0,197065 10,32185 0,0161669 0,22684034 phosphatase, receptor type, F 1393 84549 MAK16 MAK16 homolog (S. 0,1833527 8,0006058 0,0161681 0,22684034 cerevisiae) 1394 55526 DHTKD1 dehydrogenase E1 and -0,2463877 7,9505548 0,0161857 0,2269248 transketolase domain containing 1 1395 23261 CAMTA1 calmodulin binding -0,0543279 6,118933 0,0162153 0,22717737 transcription activator 1 1396 54981 NMRK1 nicotinamide riboside -0,1892031 10,809098 0,0162726 0,22781592 kinase 1 1397 51260 PBDC1 polysaccharide 0,16508681 8,0525057 0,0162865 0,22784778 biosynthesis domain containing 1 1398 4354 MPP1 membrane protein, 0,16916329 7,9420143 0,0162992 0,22786234 palmitoylated 1, 55kDa

1399 7879 RAB7A RAB7A, member RAS 0,10090312 10,784754 0,0163315 0,22815076 oncogene family

1400 5947 RBP1 retinol binding protein -0,5168978 6,0728698 0,0163813 0,22868258 1, cellular 1401 2647 BLOC1S1 biogenesis of -0,3362944 9,1438748 0,0164135 0,22896948 lysosomal organelles complex-1, subunit 1

1402 286075 ZNF707 zinc finger protein 707 -0,2576164 2,6888953 0,01644 0,22917549

1403 4204 MECP2 methyl CpG binding -0,1435732 5,38846 0,0164763 0,22929434 protein 2 (Rett syndrome) 1404 9448 MAP4K4 mitogen-activated 0,11367578 8,2983201 0,0164799 0,22929434 protein kinase kinase kinase kinase 4

1405 8802 SUCLG1 succinate-CoA ligase, -0,1453919 12,4487 0,0164838 0,22929434 alpha subunit

1406 148534 TMEM56 transmembrane 0,24264764 8,6395892 0,0165043 0,22934761 protein 56 1407 79770 TXNDC15 thioredoxin domain 0,12972526 9,8057939 0,0165111 0,22934761 containing 15 1408 2778 GNAS GNAS complex locus -0,0740225 13,620398 0,0165313 0,22946553 1409 90102 PHLDB2 pleckstrin homology- -0,1384978 9,4904494 0,0165934 0,23014865 like domain, family B, member 2

1410 80232 WDR26 WD repeat domain 26 0,09580646 9,3082363 0,0166058 0,23014865

1411 80343 SEL1L2 sel-1 suppressor of lin- -0,696648 8,2041718 0,0166158 0,23014865 12-like 2 (C. elegans)

1412 6208 RPS14 ribosomal protein S14 -0,1786349 13,761525 0,0166678 0,23039003

1413 83939 EIF2A eukaryotic translation -0,1698618 11,413101 0,0166903 0,23039003 initiation factor 2A, 65kDa

1414 728568 C12orf73 chromosome 12 open -0,1424975 5,8829232 0,016696 0,23039003 reading frame 73

1415 10213 PSMD14 proteasome (prosome, 0,17305914 11,215422 0,0167015 0,23039003 macropain) 26S subunit, non-ATPase, 14

1416 57584 ARHGAP21 Rho GTPase activating 0,33699974 4,9058507 0,0167025 0,23039003 protein 21

1417 51088 KLHL5 kelch-like family 0,23625221 8,8731915 0,0167112 0,23039003 member 5 1418 712 C1QA complement 0,80263987 7,3977979 0,0167158 0,23039003 component 1, q subcomponent, A chain 1419 5329 PLAUR plasminogen activator, 0,67428663 7,9343432 0,0167483 0,23062321 urokinase receptor

1420 56034 PDGFC platelet derived -0,1044577 10,692257 0,0167565 0,23062321 growth factor C 1421 121665 SPPL3 signal peptide -0,1164029 8,0688491 0,0167683 0,23062321 peptidase like 3 1422 81555 YIPF5 Yip1 domain family, 0,11218488 9,751486 0,0167799 0,23062321 member 5 1423 57508 INTS2 integrator complex 0,283648 7,6499848 0,0167971 0,23069694 subunit 2 1424 8908 GYG2 glycogenin 2 -0,1546349 12,37934 0,0168356 0,23078964 1425 1454 CSNK1E casein kinase 1, -0,1424706 7,2118928 0,0168382 0,23078964 epsilon 1426 10912 GADD45G growth arrest and DNA- -0,3845058 3,519157 0,0168392 0,23078964 damage-inducible, gamma 1427 3071 NCKAP1L NCK-associated 0,14709087 2,5552058 0,0168706 0,23105711 protein 1-like 1428 9950 GOLGA5 golgin A5 0,12626435 10,14651 0,0168856 0,23110034 1429 50649 ARHGEF4 Rho guanine -0,1065468 2,4579663 0,0168995 0,23112927 nucleotide exchange factor (GEF) 4

1430 10008 KCNE3 potassium voltage- 0,33304771 6,4463016 0,0169333 0,23142946 gated channel, Isk- related family, member 3 1431 55312 RFK riboflavin kinase 0,15751581 7,8920309 0,0169733 0,23174963 1432 389677 RBM12B RNA binding motif 0,17162486 5,1939125 0,0169804 0,23174963 protein 12B 1433 27101 CACYBP calcyclin binding -0,1863963 9,4489379 0,0170481 0,23251037 protein 1434 10800 CYSLTR1 cysteinyl leukotriene 0,55414113 4,9494503 0,0170844 0,2328428 receptor 1

1435 5507 PPP1R3C protein phosphatase 1, -0,4363161 7,7625993 0,0171446 0,23350062 regulatory subunit 3C

1436 128077 LIX1L Lix1 homolog (mouse)- -0,1193052 7,468693 0,017165 0,23361639 like 1437 8662 EIF3B eukaryotic translation -0,1587056 9,5899317 0,0171778 0,23362702 initiation factor 3, subunit B

1438 116328 C8orf34 chromosome 8 open -0,4150287 6,1215 0,017193 0,23367159 reading frame 34

1439 7292 TNFSF4 tumor necrosis factor 0,06427057 2,2787208 0,0173277 0,2352053 (ligand) superfamily, member 4

1440 113189 CHST14 carbohydrate (N- -0,198941 4,0857616 0,0173347 0,2352053 acetylgalactosamine 4- 0) sulfotransferase 14

1441 51701 NLK nemo-like kinase 0,20540649 5,6686392 0,0173419 0,2352053 1442 2960 GTF2E1 general transcription 0,18211824 7,2227299 0,017354 0,2352053 factor IIE, polypeptide 1, alpha 56kDa

1443 84955 NUDCD1 NudC domain 0,20897591 5,9929998 0,01739 0,23552996 containing 1 1444 51719 CAB39 calcium binding 0,15952683 10,098065 0,0174267 0,23573159 protein 39 1445 51185 CRBN cereblon -0,140441 10,500973 0,0174295 0,23573159 1446 5438 POLR2I polymerase (RNA) II -0,2300688 10,388707 0,0174445 0,23573159 (DNA directed) polypeptide I, 14.5kDa

1447 10788 IQGAP2 IQ motif containing 1,09196987 6,56389 0,0174531 0,23573159 GTPase activating protein 2 1448 56658 TRIM39 tripartite motif -0,1946226 7,0929362 0,0174673 0,2357598 containing 39 1449 2627 GATA6 GATA binding protein -0,4716193 8,7971623 0,0175523 0,23646715 6 1450 5685 PSMA4 proteasome (prosome, 0,16591615 11,815227 0,0175636 0,23646715 macropain) subunit, alpha type, 4

1451 8220 DGCR14 DiGeorge syndrome -0,0814163 4,0421205 0,0175674 0,23646715 critical region gene 14

1452 6834 SURF1 surfeit 1 -0,1823483 10,565497 0,0175733 0,23646715 1453 64784 CRTC3 CREB regulated -0,2488049 10,62309 0,0175913 0,23646715 transcription coactivator 3 1454 51762 RAB8B RAB8B, member RAS 0,24143876 7,6859182 0,0175968 0,23646715 oncogene family

1455 84619 ZGPAT zinc finger, CCCH-type -0,2323647 5,4548053 0,0176118 0,23646715 with G patch domain

1456 55757 UGGT2 UDP-glucose 0,14875977 6,7465698 0,0176269 0,23646715 glycoprotein glucosyltransferase 2

1457 25950 RWDD3 RWD domain 0,18803287 9,4983006 0,0176286 0,23646715 containing 3 1458 3790 KCNS3 potassium voltage- 0,16251211 4,2843453 0,017692 0,23715472 gated channel, delayed- rectifier, subfamily S, member 3

1459 60485 SAV1 salvador homolog 1 -0,1865738 10,04964 0,0177261 0,23744136 (Drosophila) 1460 154043 CNKSR3 CNKSR family member 0,4433059 4,6670744 0,0177376 0,23744136 3 1461 30968 STOML2 stomatin (EPB72)-like -0,1738543 8,679016 0,0178052 0,23818252 2 1462 116461 TSEN15 TSEN15 tRNA splicing 0,24940998 7,906037 0,0178317 0,23837458 endonuclease subunit

1463 3576 IL8 interleukin 8 0,78589472 12,422699 0,0178583 0,2384108 1464 221749 PXDC1 PX domain containing 0,19244601 10,536138 0,0178621 0,2384108 1 1465 597 BCL2A1 BCL2-related protein 1,02091402 9,846406 0,0178711 0,2384108 A1 1466 1024 CDK8 cyclin-dependent 0,13965071 6,7309603 0,0179182 0,23887617 kinase 8 1467 54927 CHCHD3 coiled-coil-helix-coiled- -0,1170473 10,277095 0,017975 0,23931161 coil-helix domain containing 3 1468 133619 PRRC1 proline-rich coiled-coil 0,11996773 9,1566081 0,0180026 0,23931161 1 1469 2194 FASN fatty acid synthase -0,5399063 7,3132982 0,0180236 0,23931161 1470 143384 CACUL1 CDK2-associated, cullin 0,11709275 7,9358453 0,0180372 0,23931161 domain 1 1471 92170 MTG1 mitochondrial -0,2035895 4,9939488 0,0180488 0,23931161 ribosome-associated GTPase 1 1472 57017 COQ9 coenzyme Q9 -0,1850939 8,8452667 0,0180497 0,23931161 1473 10427 SEC24B SEC24 family member -0,1713663 10,436606 0,0180502 0,23931161 B 1474 54682 MANSC1 MANSC domain 0,19640654 9,2851936 0,0180549 0,23931161 containing 1 1475 5663 PSEN1 presenilin 1 0,1175492 7,3298354 0,0180729 0,23931161 1476 84826 SFT2D3 SFT2 domain -0,1305087 6,7089864 0,0180911 0,23931161 containing 3 1477 343069 HNRNPCL1 heterogeneous nuclear -0,7168684 4,4939441 0,0180959 0,23931161 ribonucleoprotein C- like 1

1478 6252 RTN1 reticulon 1 -0,339751 9,2516357 0,0180978 0,23931161 1479 90550 MCU mitochondrial calcium 0,11430859 7,70988 0,0181117 0,23933367 uniporter 1480 55823 VPS11 vacuolar protein -0,189128 6,4847592 0,0181239 0,2393341 sorting 11 homolog (S. cerevisiae) 1481 5211 PFKL phosphofructokinase, -0,1432989 7,0284378 0,018179 0,23983611 liver 1482 51029 DESI2 desumoylating 0,162529 8,993581 0,0181865 0,23983611 isopeptidase 2 1483 22933 SIRT2 sirtuin 2 -0,2025796 7,8604076 0,01821 0,23998353 1484 6035 RNASE1 ribonuclease, RNase A 0,63193899 11,449814 0,0183008 0,24087706 family, 1 (pancreatic)

1485 23026 MYO16 myosin XVI -0,3706802 7,0200641 0,0183024 0,24087706 1486 10892 MALT1 mucosa associated 0,14217905 6,7921069 0,018326 0,24102573 lymphoid tissue lymphoma translocation gene 1 1487 2949 GSTM5 glutathione S- 0,26590521 6,0425346 0,0183393 0,2410378 transferase mu 5 1488 3667 IRS1 insulin receptor -0,3742815 8,3560814 0,0184023 0,24170276 substrate 1 1489 831 CAST calpastatin -0,0851115 11,769103 0,0184674 0,24222103 1490 11340 EXOSC8 exosome component 8 -0,0967072 9,2400328 0,0184874 0,24222103

1491 8727 CTNNAL1 catenin (cadherin- -0,2820272 10,685019 0,0184899 0,24222103 associated protein), alpha-like 1 1492 79177 ZNF576 zinc finger protein 576 -0,0702051 4,4912292 0,0184913 0,24222103

1493 3937 LCP2 lymphocyte cytosolic 0,73718203 6,7933919 0,0185366 0,24265177 protein 2 (SH2 domain containing leukocyte protein of 76kDa)

1494 5105 PCK1 phosphoenolpyruvate -0,6168871 12,424308 0,0185743 0,24286667 carboxykinase 1 (soluble) 1495 64210 MMS19 MMS19 nucleotide -0,263881 7,1909094 0,018583 0,24286667 excision repair homolog (S. cerevisiae)

1496 81887 LAS1L LAS1-like (S. -0,1058866 5,2228752 0,0185974 0,24286667 cerevisiae) 1497 163227 ZNF100 zinc finger protein 100 -0,0819062 2,4171928 0,0186027 0,24286667

1498 292 SLC25A5 solute carrier family 25 -0,1108487 12,352216 0,0186316 0,24308186 (mitochondrial carrier; adenine nucleotide translocator), member 5

1499 4801 NFYB nuclear transcription 0,13630503 7,9086088 0,0186803 0,24355384 factor Y, beta

1500 56267 CCBL2 cysteine conjugate- -0,1930999 9,8255517 0,0187157 0,24385288 beta lyase 2 1501 261726 TIPRL TOR signaling pathway 0,12761899 8,4569615 0,018737 0,24396754 regulator 1502 55760 DHX32 DEAH (Asp-Glu-Ala-His) -0,1164124 8,8342647 0,018807 0,24456101 box polypeptide 32

1503 1520 CTSS cathepsin S 1,00202463 7,4293611 0,0188076 0,24456101 1504 56954 NIT2 nitrilase family, -0,1476432 10,465964 0,0188433 0,24486209 member 2 1505 79654 HECTD3 HECT domain -0,2627219 8,1721924 0,0188684 0,24491351 containing E3 ubiquitin protein ligase 3 1506 29083 GTPBP8 GTP-binding protein 8 -0,0981571 7,9340648 0,0188723 0,24491351 (putative) 1507 10741 RBBP9 retinoblastoma 0,17950386 5,671525 0,0189035 0,24492545 binding protein 9 1508 26000 TBC1D10B TBC1 domain family, -0,1304327 6,5695641 0,0189048 0,24492545 member 10B 1509 3838 KPNA2 karyopherin alpha 2 0,27832317 11,64906 0,0189183 0,24492545 (RAG cohort 1, importin alpha 1) 1510 10944 C11orf58 chromosome 11 open -0,0904346 10,188372 0,0189296 0,24492545 reading frame 58

1511 79169 C1orf35 chromosome 1 open -0,2462633 5,5587529 0,0189562 0,24492545 reading frame 35

1512 8874 ARHGEF7 Rho guanine -0,1208652 4,687988 0,0189625 0,24492545 nucleotide exchange factor (GEF) 7

1513 23642 SNHG1 small nucleolar RNA -0,3055901 8,5287889 0,018968 0,24492545 host gene 1 (non- protein coding) 1514 121457 IKBIP IKBKB interacting 0,22156375 6,0638574 0,0189808 0,24492545 protein 1515 11145 PLA2G16 phospholipase A2, -0,1679136 13,16858 0,018986 0,24492545 group XVI 1516 26528 DAZAP1 DAZ associated protein -0,0998448 9,7199744 0,0190791 0,2459646 1 1517 9520 NPEPPS aminopeptidase -0,1582648 9,4682371 0,0191569 0,24627766 puromycin sensitive 1518 10994 ILVBL ilvB (bacterial -0,28171 7,1873354 0,0191573 0,24627766 acetolactate synthase)- like 1519 162427 FAM134C family with sequence -0,2573458 9,0174733 0,0191763 0,24627766 similarity 134, member C 1520 10043 TOM1 target of myb1 -0,3022691 4,6639232 0,0191774 0,24627766 (chicken) 1521 25878 MXRA5 matrix-remodelling 0,70768063 10,322431 0,0191859 0,24627766 associated 5 1522 55055 ZWILCH zwilch kinetochore 0,23482032 4,0109818 0,0191905 0,24627766 protein 1523 10100 TSPAN2 tetraspanin 2 -0,3403991 4,2893053 0,0191923 0,24627766 1524 22837 COBLL1 cordon-bleu WH2 0,18806018 9,06862 0,0192042 0,24627766 repeat protein-like 1

1525 54606 DDX56 DEAD (Asp-Glu-Ala- -0,187616 6,689554 0,0192569 0,24675864 Asp) box helicase 56 1526 3841 KPNA5 karyopherin alpha 5 -0,5924554 4,9455951 0,0192763 0,24675864 (importin alpha 6) 1527 25970 SH2B1 SH2B adaptor protein -0,0512034 5,3263758 0,019283 0,24675864 1 1528 5007 OSBP oxysterol binding -0,0989847 8,3362238 0,0192969 0,24675864 protein 1529 11188 NISCH nischarin -0,0943517 5,3377079 0,0193056 0,24675864 1530 4817 NIT1 nitrilase 1 -0,1809335 8,0146735 0,0193196 0,24675864 1531 4282 MIF macrophage migration 0,23505642 10,594977 0,0193301 0,24675864 inhibitory factor (glycosylation- inhibiting factor) 1532 91746 YTHDC1 YTH domain containing -0,0896789 7,4389632 0,0193846 0,24718507 1 1533 9014 TAF1B TATA box binding 0,28910302 7,0355558 0,0193888 0,24718507 protein (TBP)- associated factor, RNA polymerase I, B, 63kDa

1534 23387 SIK3 SIK family kinase 3 -0,123644 6,3155825 0,0194228 0,24745716 1535 673 BRAF v-raf murine sarcoma -0,2067634 6,7942289 0,0194473 0,24760721 viral oncogene homolog B

1536 388695 LYSMD1 LysM, putative -0,2490829 2,6332943 0,0194634 0,24765101 peptidoglycan-binding, domain containing 1

1537 3201 HOXA4 homeobox A4 -0,2619533 5,2834002 0,0194801 0,24770252 1538 3309 HSPA5 heat shock 70kDa 0,25805482 7,265806 0,0195118 0,24786167 protein 5 (glucose- regulated protein, 78kDa) 1539 11167 FSTL1 follistatin-like 1 0,21000755 13,512328 0,0195281 0,24786167 1540 55790 CSGALNAC chondroitin sulfate N- 0,4908926 7,625343 0,0195306 0,24786167 T1 acetylgalactosaminyltr ansferase 1

1541 7004 TEAD4 TEA domain family -0,1886424 4,0580464 0,0195733 0,24824191 member 4 1542 9731 CEP104 centrosomal protein 0,1266884 7,2018259 0,0195901 0,24829338 104kDa 1543 23411 SIRT1 sirtuin 1 -0,3069067 10,980962 0,0196077 0,24835542 1544 85329 LGALS12 lectin, galactoside- -0,5192121 11,017203 0,0196244 0,24840684 binding, soluble, 12 1545 6051 RNPEP arginyl 0,15071908 8,4628997 0,0196483 0,24845458 aminopeptidase (aminopeptidase B) 1546 204851 HIPK1 homeodomain 0,05510617 6,4576164 0,0196536 0,24845458 interacting protein kinase 1 1547 1234 CCR5 chemokine (C-C motif) 0,29143999 2,3931674 0,0197062 0,248958 receptor 5 (gene/pseudogene) 1548 51312 SLC25A37 solute carrier family 25 0,13409901 6,8746912 0,019767 0,24956466 (mitochondrial iron transporter), member 37 1549 404201 WDFY3- WDFY3 antisense RNA -0,1969072 4,9082046 0,0198177 0,25004375 AS2 2 1550 6472 SHMT2 serine -0,115523 6,3936821 0,0198529 0,25032616 hydroxymethyltransfer ase 2 (mitochondrial)

1551 55005 RMND1 required for meiotic -0,1733532 8,7883339 0,0198845 0,25056254 nuclear division 1 homolog (S. cerevisiae)

1552 2145 EZH1 enhancer of zeste -0,2084514 8,5346121 0,0198994 0,25058844 homolog 1 (Drosophila) 1553 6038 RNASE4 ribonuclease, RNase A -0,1766772 12,577694 0,0199376 0,25090776 family, 4 1554 79832 QSER1 glutamine and serine -0,0692953 4,4631422 0,0199734 0,2511653 rich 1 1555 5781 PTPN11 protein tyrosine 0,14785909 6,115955 0,0199837 0,2511653 phosphatase, non- receptor type 11 1556 54788 DNAJB12 DnaJ (Hsp40) homolog, -0,0704821 6,5026636 0,0200199 0,25145844 subfamily B, member 12 1557 4731 NDUFV3 NADH dehydrogenase -0,1959764 8,3224592 0,0200878 0,25214852 (ubiquinone) flavoprotein 3, 10kDa

1558 83707 TRPT1 tRNA -0,2661553 7,7268476 0,0201192 0,25237382 phosphotransferase 1

1559 8896 BUD31 BUD31 homolog (S. -0,1306179 9,8358418 0,0201315 0,25237382 cerevisiae) 1560 22875 ENPP4 ectonucleotide 0,20413 9,0498068 0,0201495 0,25243713 pyrophosphatase/phos phodiesterase 4 (putative) 1561 9770 RASSF2 Ras association 0,68069485 5,351708 0,0202462 0,25323662 (RalGDS/AF-6) domain family member 2 1562 641638 SNHG6 small nucleolar RNA -0,186152 12,489768 0,0202499 0,25323662 host gene 6 (non- protein coding) 1563 55051 NRDE2 NRDE-2, necessary for -0,0558193 3,8834337 0,0202522 0,25323662 RNA interference, domain containing

1564 51251 NT5C3A 5'-nucleotidase, -0,1047955 9,0427056 0,0202669 0,25325835 cytosolic IIIA 1565 27043 PELP1 proline, glutamate and -0,2432712 5,1483971 0,0203707 0,25437468 leucine rich protein 1

1566 286437 LOC28643 uncharacterized 0,15648725 6,1577126 0,0203942 0,25437468 7 LOC286437 1567 9601 PDIA4 protein disulfide 0,14000242 6,7610254 0,0204011 0,25437468 isomerase family A, member 4 1568 1213 CLTC clathrin, heavy chain 0,08374481 12,915356 0,0204375 0,25437468 (Hc) 1569 51330 TNFRSF12 tumor necrosis factor 0,30057161 7,8226838 0,020443 0,25437468 A receptor superfamily, member 12A

1570 202151 RANBP3L RAN binding protein 3- 0,43114752 2,5095917 0,0204452 0,25437468 like 1571 8974 P4HA2 prolyl 4-hydroxylase, 0,33190312 7,0667057 0,0204659 0,25437468 alpha polypeptide II

1572 10209 EIF1 eukaryotic translation -0,1489536 14,089769 0,0204786 0,25437468 initiation factor 1

1573 116039 OSR2 odd-skipped related -0,2724058 9,2179643 0,0204824 0,25437468 transciption factor 2

1574 10673 TNFSF13B tumor necrosis factor 0,67356005 4,8757546 0,0204864 0,25437468 (ligand) superfamily, member 13b

1575 8636 SSNA1 Sjogren syndrome -0,2631029 7,4640823 0,0205011 0,25439628 nuclear autoantigen 1

1576 274 BIN1 bridging integrator 1 -0,2540319 8,285975 0,0205651 0,25502822

1577 5611 DNAJC3 DnaJ (Hsp40) homolog, 0,10645263 8,6733423 0,020583 0,25508791 subfamily C, member 3

1578 100506243 KRBOX1 KRAB box domain -0,3327842 4,3841988 0,0206709 0,25570905 containing 1 1579 254428 SLC41A1 solute carrier family 41 -0,1987229 7,9889915 0,0206761 0,25570905 (magnesium transporter), member 1 1580 134147 CMBL carboxymethylenebute -0,0849178 8,2191216 0,0206794 0,25570905 nolidase homolog (Pseudomonas)

1581 1856 DVL2 dishevelled segment -0,1493786 6,8390538 0,0206854 0,25570905 polarity protein 2

1582 56288 PARD3 par-3 family cell -0,1171311 7,0633193 0,0207365 0,2560169 polarity regulator 1583 6667 SP1 Sp1 transcription -0,1446238 6,0577031 0,0207365 0,2560169 factor 1584 26355 FAM162A family with sequence -0,1361496 11,701775 0,0207779 0,25636569 similarity 162, member A 1585 2309 FOXO3 forkhead box O3 -0,2449811 9,6462794 0,0208167 0,25668193 1586 401265 KLHL31 kelch-like family 0,25529595 5,1361 0,0208797 0,25726461 member 31 1587 64743 WDR13 WD repeat domain 13 -0,1869223 8,1358161 0,0208902 0,25726461

1588 64092 SAMSN1 SAM domain, SH3 1,13560319 6,734437 0,0209215 0,25740317 domain and nuclear localization signals 1

1589 521 ATP5I ATP synthase, H+ -0,1520161 11,505059 0,0209294 0,25740317 transporting, mitochondrial Fo complex, subunit E 1590 364 AQP7 aquaporin 7 -0,2256786 10,362777 0,020941 0,25740317 1591 7771 ZNF112 zinc finger protein 112 0,31848706 3,2297375 0,0209814 0,25765394

1592 254225 RNF169 ring finger protein 169 -0,186177 7,1049882 0,0209878 0,25765394

1593 10402 ST3GAL6 ST3 beta-galactoside -0,4622027 7,0896495 0,0210238 0,25782522 alpha-2,3- sialyltransferase 6

1594 2926 GRSF1 G-rich RNA sequence -0,106805 8,7633128 0,0210281 0,25782522 binding factor 1

1595 1628 DBP D site of albumin -0,5546762 7,562844 0,0210691 0,25791015 promoter (albumin D- box) binding protein 1596 7508 XPC xeroderma -0,1796213 8,3718561 0,0210789 0,25791015 pigmentosum, complementation group C 1597 10572 SIVA1 SIVA1, apoptosis- -0,1876127 8,3502909 0,0210849 0,25791015 inducing factor 1598 11213 IRAK3 interleukin-1 receptor- -0,2021764 5,5955185 0,0210878 0,25791015 associated kinase 3

1599 131616 TMEM42 transmembrane -0,169652 8,1032285 0,0211086 0,25791432 protein 42 1600 22869 ZNF510 zinc finger protein 510 -0,284711 3,9079293 0,0211146 0,25791432

1601 51227 PIGP phosphatidylinositol -0,1670835 11,378313 0,0211905 0,25868071 glycan anchor biosynthesis, class P 1602 64420 SUSD1 sushi domain 0,17763187 5,3797424 0,0212234 0,25888625 containing 1 1603 5607 MAP2K5 mitogen-activated -0,2431435 6,5582905 0,0212339 0,25888625 protein kinase kinase 5

1604 56911 MAP3K7CL MAP3K7 C-terminal 0,36499507 5,0062101 0,0212656 0,25907159 like 1605 23471 TRAM1 translocation 0,1274578 11,050506 0,021283 0,25907159 associated membrane protein 1

1606 7305 TYROBP TYRO protein tyrosine 1,1193564 7,7461622 0,0212888 0,25907159 kinase binding protein

1607 5321 PLA2G4A phospholipase A2, 0,39196447 9,9042823 0,0213259 0,25936174 group IVA (cytosolic, calcium-dependent)

1608 51727 CMPK1 cytidine 0,07368969 10,279048 0,0214126 0,26010457 monophosphate (UMP- CMP) kinase 1, cytosolic 1609 57506 MAVS mitochondrial antiviral -0,2035078 7,4136941 0,0214347 0,26010457 signaling protein

1610 81894 SLC25A28 solute carrier family 25 -0,0461689 4,9072051 0,0214465 0,26010457 (mitochondrial iron transporter), member 28 1611 51000 SLC35B3 solute carrier family 35 0,16717136 10,043862 0,0214529 0,26010457 (adenosine 3'-phospho 5'-phosphosulfate transporter), member B3

1612 7095 SEC62 SEC62 homolog (S. 0,14411236 10,285601 0,0214536 0,26010457 cerevisiae) 1613 11337 GABARAP GABA(A) receptor- -0,131527 12,716184 0,0214817 0,26028459 associated protein 1614 100507632 LINC00968 long intergenic non- 1,09685412 8,7304107 0,0215155 0,26053229 protein coding RNA 968 1615 10437 IFI30 interferon, gamma- 1,40586283 7,1042369 0,021552 0,26081275 inducible protein 30 1616 81556 VWA9 von Willebrand factor -0,1122071 6,8684358 0,0215878 0,26101926 A domain containing 9

1617 8934 RAB7L1 RAB7, member RAS 0,11844419 8,0079502 0,0215958 0,26101926 oncogene family-like 1

1618 8798 DYRK4 dual-specificity -0,1450107 5,4155617 0,0216328 0,26130458 tyrosine-(Y)- phosphorylation regulated kinase 4 1619 22919 MAPRE1 microtubule- 0,08839738 10,085817 0,0216846 0,26167413 associated protein, RP/EB family, member 1 1620 23361 ZNF629 zinc finger protein 629 -0,2030178 5,2493299 0,0217014 0,26167413

1621 64858 DCLRE1B DNA cross-link repair 0,22357839 5,3655911 0,0217133 0,26167413 1B 1622 6249 CLIP1 CAP-GLY domain 0,20835168 8,2076113 0,0217169 0,26167413 containing linker protein 1 1623 327 APEH acylaminoacyl-peptide -0,2684162 6,9736356 0,021775 0,2622128 hydrolase 1624 100506388 LOC10050 uncharacterized 0,3012881 3,4342831 0,0217906 0,26223858 6388 LOC100506388 1625 901 CCNG2 cyclin G2 -0,3803458 9,8206122 0,0218091 0,26230022 1626 1974 EIF4A2 eukaryotic translation -0,1641755 13,310876 0,0218298 0,26238712 initiation factor 4A2

1627 1894 ECT2 epithelial cell 0,37575354 6,2526282 0,0218681 0,2626601 transforming 2 1628 6205 RPS11 ribosomal protein S11 -0,0960574 15,367701 0,0218794 0,2626601

1629 10974 ADIRF adipogenesis -0,1828081 13,914971 0,0219176 0,26275337 regulatory factor 1630 10042 HMGXB4 HMG box domain -0,1621162 8,2061405 0,0219234 0,26275337 containing 4 1631 1939 EIF2D eukaryotic translation -0,1912724 9,4527445 0,021935 0,26275337 initiation factor 2D

1632 117145 THEM4 thioesterase -0,1613087 8,2174778 0,0219409 0,26275337 superfamily member 4

1633 594 BCKDHB branched chain keto -0,259098 7,861586 0,021968 0,26283494 acid dehydrogenase E1, beta polypeptide

1634 7916 PRRC2A proline-rich coiled-coil -0,1957212 6,6032935 0,0219751 0,26283494 2A 1635 1503 CTPS1 CTP synthase 1 0,1795384 2,2631503 0,0219881 0,26283494 1636 7818 DAP3 death associated -0,1066738 11,264465 0,0220168 0,26301775 protein 3 1637 6832 SUPV3L1 suppressor of var1, 3- -0,2033968 7,6283134 0,0220339 0,26306084 like 1 (S. cerevisiae)

1638 28232 SLCO3A1 solute carrier organic 0,18218563 5,1905575 0,0220532 0,26307925 anion transporter family, member 3A1

1639 55844 PPP2R2D protein phosphatase 2, -0,1209677 7,2885428 0,0220697 0,26307925 regulatory subunit B, delta

1640 10346 TRIM22 tripartite motif 0,30224667 10,149206 0,0220758 0,26307925 containing 22 1641 203069 R3HCC1 R3H domain and coiled- -0,1675395 8,7451343 0,02209 0,2630878 coil containing 1

1642 9595 CYTIP cytohesin 1 interacting 0,71284557 4,2098395 0,0221145 0,26321911 protein 1643 219927 MRPL21 mitochondrial -0,1893641 8,9568951 0,0221351 0,26330441 ribosomal protein L21

1644 25942 SIN3A SIN3 transcription -0,1853115 6,2213505 0,0222178 0,26404784 regulator family member A 1645 801 CALM1 calmodulin 1 0,11261429 12,764628 0,0222256 0,26404784 (phosphorylase kinase, delta) 1646 27248 ERLEC1 endoplasmic reticulum 0,07740477 10,223076 0,0222382 0,26404784 lectin 1 1647 8666 EIF3G eukaryotic translation -0,2079949 11,009983 0,0222555 0,26409346 initiation factor 3, subunit G 1648 91574 C12orf65 chromosome 12 open -0,2111423 5,2789585 0,0222839 0,26417841 reading frame 65

1649 1601 DAB2 Dab, mitogen- 0,21248273 9,485034 0,0223219 0,26417841 responsive phosphoprotein, homolog 2 (Drosophila) 1650 54973 CPSF3L cleavage and -0,167226 6,692093 0,0223233 0,26417841 polyadenylation specific factor 3-like 1651 51283 BFAR bifunctional apoptosis -0,1362534 8,8912947 0,0223234 0,26417841 regulator 1652 79869 CPSF7 cleavage and -0,1281904 9,2742888 0,0223303 0,26417841 polyadenylation specific factor 7, 59kDa 1653 23380 SRGAP2 SLIT-ROBO Rho GTPase 0,06531724 2,3660222 0,0223642 0,26442007 activating protein 2

1654 220 ALDH1A3 aldehyde 1,0417088 6,6762149 0,0223978 0,26465732 dehydrogenase 1 family, member A3 1655 92399 MRRF mitochondrial 0,23745266 3,522192 0,0224403 0,26499869 ribosome recycling factor 1656 9961 MVP major vault protein 0,35209934 8,1110692 0,0224948 0,26548155 1657 54539 NDUFB11 NADH dehydrogenase -0,1756238 11,210626 0,0225293 0,26565478 (ubiquinone) 1 beta subcomplex, 11, 17.3kDa

1658 56882 CDC42SE1 CDC42 small effector 1 0,18844267 5,9542466 0,0225366 0,26565478

1659 54984 PINX1 PIN2/TERF1 -0,220185 5,0741825 0,0225845 0,26605924 interacting, telomerase inhibitor 1

1660 6229 RPS24 ribosomal protein S24 -0,096846 14,802359 0,022628 0,26630098

1661 7249 TSC2 tuberous sclerosis 2 -0,3586404 6,2760435 0,0226323 0,26630098 1662 729013 ZBED5-AS1 ZBED5 antisense RNA 1 0,1749259 5,9781282 0,0226553 0,26641162

1663 64854 USP46 ubiquitin specific 0,10842312 6,2937173 0,0227199 0,26700972 peptidase 46 1664 54784 ALKBH4 alkB, alkylation repair -0,2030837 4,1964487 0,0227562 0,26727574 homolog 4 (E. coli)

1665 169270 ZNF596 zinc finger protein 596 -0,2859678 4,7185602 0,0227724 0,26730518 1666 80014 WWC2 WW and C2 domain 0,20140035 5,9447342 0,0228053 0,26753157 containing 2 1667 5480 PPIC peptidylprolyl 0,23767305 10,246165 0,0228238 0,26758713 isomerase C (cyclophilin C) 1668 131870 NUDT16 nudix (nucleoside -0,1118777 5,9006758 0,0228451 0,26767693 diphosphate linked moiety X)-type motif 16 1669 1633 DCK deoxycytidine kinase 0,21175493 8,5840881 0,0228818 0,26786643

1670 57827 C6orf47 chromosome 6 open -0,1518533 4,5552169 0,0228998 0,26786643 reading frame 47

1671 57688 ZSWIM6 zinc finger, SWIM-type 0,32806478 8,8536184 0,0229024 0,26786643 containing 6 1672 9217 VAPB VAMP (vesicle- -0,1556989 7,8772342 0,0229356 0,26795725 associated membrane protein)-associated protein B and C

1673 4267 CD99 CD99 molecule 0,11454518 12,195642 0,0229376 0,26795725 1674 338773 TMEM119 transmembrane 0,46306738 3,2721039 0,0229919 0,26802538 protein 119 1675 84747 UNC119B unc-119 homolog B (C. -0,0977165 9,4754463 0,0229995 0,26802538 elegans) 1676 56983 POGLUT1 protein O- 0,26972785 6,1153106 0,0230003 0,26802538 glucosyltransferase 1

1677 145389 SLC38A6 solute carrier family 0,27692776 8,628417 0,0230057 0,26802538 38, member 6 1678 27 ABL2 c-abl oncogene 2, non- 0,33343818 6,8522246 0,023012 0,26802538 receptor tyrosine kinase 1679 27429 HTRA2 HtrA serine peptidase -0,1382136 7,7900512 0,023064 0,26847121 2 1680 7044 LEFTY2 left-right -1,1485844 5,0541139 0,0230864 0,26854535 determination factor 2

1681 23493 HEY2 hes-related family -0,3656221 4,1106413 0,0230979 0,26854535 bHLH transcription factor with YRPW motif 2 1682 85457 CIPC CLOCK-interacting -0,1877467 9,1534637 0,0231207 0,26863102 pacemaker 1683 683 BST1 bone marrow stromal 0,32910812 6,3364504 0,0231327 0,26863102 cell antigen 1 1684 56920 SEMA3G sema domain, 0,44266397 11,623808 0,0231971 0,26921853 immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3G 1685 134 ADORA1 adenosine A1 receptor -0,2197664 5,840803 0,0233088 0,2703544

1686 55197 RPRD1A regulation of nuclear 0,10559245 8,1579458 0,0233366 0,27051639 pre-mRNA domain containing 1A

1687 64778 FNDC3B fibronectin type III 0,12790119 9,9615405 0,0233638 0,27067146 domain containing 3B

1688 969 CD69 CD69 molecule 0,87185486 4,8717624 0,0234223 0,27118837 1689 55011 PIH1D1 PIH1 domain -0,1315941 8,8234757 0,023478 0,27167157 containing 1 1690 11037 STON1 stonin 1 -0,2887586 9,4597073 0,0235749 0,27263154 1691 11098 PRSS23 protease, serine, 23 0,73682485 7,247434 0,0236322 0,27290174 1692 84034 EMILIN2 elastin microfibril 0,32895596 3,2929723 0,0236371 0,27290174 interfacer 2 1693 6443 SGCB sarcoglycan, beta 0,18454142 9,6520795 0,0236525 0,27290174 (43kDa dystrophin- associated glycoprotein) 1694 10981 RAB32 RAB32, member RAS 0,22894761 8,2609329 0,0236598 0,27290174 oncogene family

1695 5527 PPP2R5C protein phosphatase 2, 0,10912072 9,9197841 0,0236793 0,27290174 regulatory subunit B', gamma

1696 54816 ZNF280D zinc finger protein -0,2430095 8,2031786 0,0236932 0,27290174 280D 1697 6363 CCL19 chemokine (C-C motif) 1,10467659 7,2660206 0,023696 0,27290174 ligand 19 1698 23524 SRRM2 serine/arginine -0,1980846 8,7956556 0,0237857 0,27369285 repetitive matrix 2 1699 50856 CLEC4A C-type lectin domain 0,36915318 2,5224262 0,0237927 0,27369285 family 4, member A

1700 91433 RCCD1 RCC1 domain -0,2337321 6,7102966 0,0238079 0,27369996 containing 1 1701 100129794 SLC25A21- SLC25A21 antisense -0,3055023 5,5019749 0,0238213 0,27369996 AS1 RNA 1 1702 7903 ST8SIA4 ST8 alpha-N-acetyl- 0,30354386 3,7803013 0,0238601 0,27398471 neuraminide alpha-2,8- sialyltransferase 4 1703 128387 TATDN3 TatD DNase domain -0,1636849 7,2633167 0,0238862 0,27412293 containing 3 1704 25989 ULK3 unc-51 like kinase 3 0,15350062 4,2426507 0,023918 0,27422357 1705 84522 JAGN1 jagunal homolog 1 -0,125451 9,5978997 0,0239426 0,27422357 (Drosophila) 1706 2710 GK glycerol kinase 0,51786249 3,657485 0,0239471 0,27422357 1707 7172 TPMT thiopurine S- 0,14859541 3,2279506 0,0239625 0,27422357 methyltransferase 1708 54776 PPP1R12C protein phosphatase 1, -0,2272623 7,5108814 0,0239651 0,27422357 regulatory subunit 12C

1709 55178 RNMTL1 RNA methyltransferase -0,1938525 7,4683035 0,0239819 0,27425578 like 1

1710 23085 ERC1 ELKS/RAB6- 0,09327272 5,5814774 0,0240408 0,27476809 interacting/CAST family member 1 1711 54879 ST7L suppression of 0,05713452 2,7218115 0,0240877 0,27514306 tumorigenicity 7 like

1712 4802 NFYC nuclear transcription -0,132022 6,1664664 0,0241335 0,2755055 factor Y, gamma

1713 6772 STAT1 signal transducer and 0,36173721 7,7864713 0,0241777 0,27584895 activator of transcription 1, 91kDa

1714 729799 SEC14L1P1 SEC14-like 1 -0,1184779 2,2886196 0,0242334 0,27614536 pseudogene 1 1715 65985 AACS acetoacetyl-CoA -0,5912438 10,316336 0,0242476 0,27614536 synthetase 1716 10487 CAP1 CAP, adenylate cyclase- 0,13645692 11,627452 0,0242559 0,27614536 associated protein 1 (yeast) 1717 6309 SC5D sterol-C5-desaturase -0,3257075 9,5822635 0,0242615 0,27614536

1718 10308 ZNF267 zinc finger protein 267 0,5038148 7,8613235 0,0242759 0,27614536

1719 79648 MCPH1 microcephalin 1 -0,1290413 3,1459069 0,0243047 0,27614536 1720 5000 ORC4 origin recognition -0,1125526 6,4431417 0,0243049 0,27614536 complex, subunit 4 1721 388272 C16orf87 chromosome 16 open 0,29240169 7,4691554 0,0243391 0,27614536 reading frame 87

1722 323 APBB2 amyloid beta (A4) -0,1436664 8,9392804 0,0243439 0,27614536 precursor protein- binding, family B, member 2 1723 51608 GET4 golgi to ER traffic -0,0670445 4,9595722 0,024345 0,27614536 protein 4 homolog (S. cerevisiae) 1724 11078 TRIOBP TRIO and F-actin -0,1509696 8,8041308 0,024382 0,27640441 binding protein 1725 1408 CRY2 cryptochrome -0,2535741 9,1202434 0,0244062 0,27651867 circadian clock 2 1726 28973 MRPS18B mitochondrial -0,1410164 8,9661294 0,024431 0,27652138 ribosomal protein S18B 1727 55714 TENM3 teneurin -0,0774725 2,2072976 0,0244426 0,27652138 transmembrane protein 3 1728 23086 EXPH5 exophilin 5 -0,3566575 2,809989 0,0244542 0,27652138 1729 101927275 RP11- uncharacterized 0,08011114 2,2670045 0,0244657 0,27652138 143J12.2 LOC101927275 1730 3225 HOXC9 homeobox C9 -0,2020926 5,3880837 0,0244772 0,27652138 1731 5955 RCN2 reticulocalbin 2, EF- 0,15175386 10,529887 0,0245141 0,27659703 hand calcium binding domain 1732 10983 CCNI cyclin I -0,1689605 12,306372 0,0245206 0,27659703 1733 8209 C21orf33 chromosome 21 open -0,1811645 9,0348566 0,0245366 0,27659703 reading frame 33

1734 22856 CHSY1 chondroitin sulfate 0,31610791 9,0960894 0,0245405 0,27659703 synthase 1 1735 7430 EZR ezrin 0,37563671 7,2480462 0,0245663 0,27661951 1736 90459 ERI1 exoribonuclease 1 0,13073314 7,0422226 0,0245708 0,27661951 1737 9334 B4GALT5 UDP-Gal:betaGlcNAc 0,23518305 9,4612474 0,0246028 0,27682073 beta 1,4- galactosyltransferase, polypeptide 5

1738 79039 DDX54 DEAD (Asp-Glu-Ala- -0,1176303 5,1934125 0,024638 0,27705717 Asp) box polypeptide 54 1739 23589 CARHSP1 calcium regulated heat -0,2108828 7,3916899 0,0246525 0,27706029 stable protein 1, 24kDa 1740 8411 EEA1 early endosome 0,31732563 8,8495051 0,0246946 0,27725557 antigen 1 1741 57495 NWD2 NACHT and WD repeat -1,3728057 4,7549755 0,0246982 0,27725557 domain containing 2

1742 92689 FAM114A1 family with sequence 0,11788659 9,8438405 0,0247444 0,27761442 similarity 114, member A1 1743 84947 SERAC1 serine active site 0,26357328 5,6173786 0,0247749 0,27779747 containing 1 1744 51076 CUTC cutC copper 0,23184501 9,0185261 0,024832 0,27827734 transporter 1745 10495 ENOX2 ecto-NOX disulfide- 0,09619722 6,3512543 0,0248661 0,27849979 thiol exchanger 2 1746 79157 MFSD11 major facilitator 0,12994214 6,6720524 0,0249584 0,27937363 superfamily domain containing 11 1747 24147 FJX1 four jointed box 1 0,2893126 3,6149773 0,0249839 0,27949883 (Drosophila) 1748 5859 QARS glutaminyl-tRNA -0,1910628 10,50888 0,0250082 0,27961085 synthetase 1749 7263 TST thiosulfate -0,1997904 10,920696 0,0250409 0,27968794 sulfurtransferase (rhodanese) 1750 64965 MRPS9 mitochondrial -0,2019169 7,7445705 0,0250485 0,27968794 ribosomal protein S9

1751 523 ATP6V1A ATPase, H+ 0,22701224 8,9535416 0,025058 0,27968794 transporting, lysosomal 70kDa, V1 subunit A 1752 23216 TBC1D1 TBC1 (tre-2/USP6, -0,089284 2,9793618 0,0251481 0,28038809 BUB2, cdc16) domain family, member 1

1753 400566 C17orf97 chromosome 17 open -0,4400428 4,0386992 0,0251494 0,28038809 reading frame 97

1754 1071 CETP cholesteryl ester -0,6851134 3,5712198 0,0251884 0,28066279 transfer protein, plasma 1755 7248 TSC1 tuberous sclerosis 1 -0,1057678 9,3954618 0,0252186 0,28083895 1756 138716 RPP25L ribonuclease P/MRP -0,2074421 7,3576987 0,0252796 0,28135761 25kDa subunit-like 1757 79932 KIAA0319L KIAA0319-like -0,1364066 6,1173996 0,0253503 0,28179636

1758 4097 MAFG v-maf avian 0,14444391 5,7060777 0,0253583 0,28179636 musculoaponeurotic fibrosarcoma oncogene homolog G

1759 54386 TERF2IP telomeric repeat -0,0969554 10,565839 0,0253622 0,28179636 binding factor 2, interacting protein 1760 203259 FAM219A family with sequence 0,17142842 3,5445676 0,0253936 0,28190963 similarity 219, member A 1761 53342 IL17D interleukin 17D 0,44735078 3,3459371 0,02541 0,28190963 1762 51004 COQ6 coenzyme Q6 -0,2761659 6,1154396 0,0254157 0,28190963 monooxygenase 1763 163786 SASS6 spindle assembly 6 0,28126394 5,0909916 0,0254808 0,28247074 homolog (C. elegans)

1764 1196 CLK2 CDC-like kinase 2 -0,1807411 7,2780814 0,0255211 0,2827573 1765 100303755 PET117 PET117 homolog (S. -0,1991198 8,160176 0,0255717 0,28315746 cerevisiae) 1766 740 MRPL49 mitochondrial -0,1901405 8,9848685 0,0256116 0,28340232 ribosomal protein L49

1767 54540 FAM193B family with sequence -0,1994898 5,7871313 0,0256228 0,28340232 similarity 193, member B 1768 29888 STRN4 striatin, calmodulin -0,2057258 5,0202955 0,0256993 0,28408754 binding protein 4 1769 2760 GM2A GM2 ganglioside 0,21943265 5,7745304 0,0257576 0,28457135 activator 1770 55827 DCAF6 DDB1 and CUL4 0,12737158 10,013572 0,0257932 0,28467962 associated factor 6 1771 56181 MTFR1L mitochondrial fission -0,1799701 8,744593 0,0257965 0,28467962 regulator 1-like

1772 6775 STAT4 signal transducer and -0,474787 4,7147051 0,0259139 0,28567412 activator of transcription 4 1773 10276 NET1 neuroepithelial cell -0,2818623 11,339322 0,0259289 0,28567412 transforming 1 1774 374387 DKFZp779 uncharacterized -0,2837574 4,4179044 0,0259305 0,28567412 M0652 DKFZp779M0652 1775 2539 G6PD glucose-6-phosphate -0,1930238 6,0986365 0,0259721 0,28590483 dehydrogenase

1776 1877 E4F1 E4F transcription -0,2874497 5,8512134 0,0259845 0,28590483 factor 1 1777 9469 CHST3 carbohydrate 0,16288826 4,7422925 0,0259953 0,28590483 (chondroitin 6) sulfotransferase 3 1778 6660 SOX5 SRY (sex determining -0,2199376 7,0561898 0,0261082 0,28687512 region Y)-box 5

1779 6480 ST6GAL1 ST6 beta- 0,17756792 3,7464545 0,0261129 0,28687512 galactosamide alpha- 2,6-sialyltranferase 1

1780 3303 HSPA1A heat shock 70kDa -0,1732765 13,689601 0,026229 0,28798895 protein 1A 1781 64897 C12orf43 chromosome 12 open -0,2607832 7,1183639 0,0262492 0,28804842 reading frame 43

1782 10783 NEK6 NIMA-related kinase 6 0,21012521 6,6212966 0,0263239 0,2887064 1783 57179 KIAA1191 KIAA1191 -0,0919361 10,59131 0,0263466 0,28876158 1784 92259 MRPS36 mitochondrial -0,2075462 9,4028333 0,0263585 0,28876158 ribosomal protein S36

1785 54951 COMMD8 COMM domain 0,18086866 9,1735127 0,0263848 0,28888757 containing 8 1786 51196 PLCE1 phospholipase C, -0,2304352 6,3097144 0,0264072 0,28897069 epsilon 1 1787 728730 AC007246. uncharacterized 0,39303804 7,0233135 0,0264444 0,28921655 3 LOC728730 1788 79180 EFHD2 EF-hand domain 0,19313354 5,9593232 0,0264951 0,28950091 family, member D2 1789 8522 GAS7 growth arrest-specific 0,27009764 3,3426263 0,0265001 0,28950091 7 1790 8775 NAPA N-ethylmaleimide- -0,1849512 7,7895024 0,0265401 0,28973041 sensitive factor attachment protein, alpha 1791 8766 RAB11A RAB11A, member RAS 0,06822152 10,134526 0,0265507 0,28973041 oncogene family

1792 9562 MINPP1 multiple inositol- 0,16219528 7,9870971 0,0266355 0,29034889 polyphosphate phosphatase 1 1793 22998 LIMCH1 LIM and calponin 0,2586136 11,58288 0,0266371 0,29034889 homology domains 1

1794 92715 DPH7 diphthamide -0,1207357 5,6149911 0,0267041 0,29078696 biosynthesis 7 1795 22916 NCBP2 nuclear cap binding 0,13031379 8,4131228 0,0267071 0,29078696 protein subunit 2, 20kDa 1796 2826 CCR10 chemokine (C-C motif) -0,2990856 2,3645938 0,0267472 0,29101685 receptor 10 1797 10713 USP39 ubiquitin specific -0,1548613 7,2681779 0,0267579 0,29101685 peptidase 39 1798 11147 HHLA3 HERV-H LTR- -0,274796 2,6076674 0,026774 0,2910294 associating 3 1799 283237 TTC9C tetratricopeptide -0,0860719 2,4637114 0,0268467 0,29165789 repeat domain 9C 1800 148867 SLC30A7 solute carrier family 30 0,12937931 6,1333304 0,0268853 0,29177395 (zinc transporter), member 7

1801 1841 DTYMK deoxythymidylate 0,10440924 7,044664 0,0268992 0,29177395 kinase (thymidylate kinase) 1802 25992 SNED1 sushi, nidogen and EGF- -0,2658231 6,2944368 0,0269022 0,29177395 like domains 1 1803 10922 FASTK Fas-activated -0,1938652 5,8861303 0,0269245 0,29185356 serine/threonine kinase 1804 374291 NDUFS7 NADH dehydrogenase -0,1901257 9,3520936 0,0269685 0,29216878 (ubiquinone) Fe-S protein 7, 20kDa (NADH-coenzyme Q reductase)

1805 920 CD4 CD4 molecule 0,19623456 4,5399564 0,0270253 0,29262155 1806 858 CAV2 caveolin 2 0,11559247 14,078766 0,0270479 0,29270421 1807 54495 TMX3 thioredoxin-related 0,19693769 10,340174 0,0270723 0,2928064 transmembrane protein 3 1808 79739 TTLL7 tubulin tyrosine ligase- -0,4736499 6,9847287 0,0271678 0,29367637 like family, member 7

1809 286319 TUSC1 tumor suppressor -0,1697155 10,379227 0,0272235 0,29411592 candidate 1 1810 11120 BTN2A1 butyrophilin, subfamily 0,12987166 5,4712381 0,0272415 0,29411592 2, member A1

1811 2130 EWSR1 EWS RNA-binding 0,0480887 4,3218 0,0272536 0,29411592 protein 1 1812 53981 CPSF2 cleavage and 0,23510531 7,2974836 0,0272712 0,29414341 polyadenylation specific factor 2, 100kDa 1813 5777 PTPN6 protein tyrosine 0,30793004 4,7996122 0,0272941 0,29422825 phosphatase, non- receptor type 6 1814 7553 ZNF7 zinc finger protein 7 -0,1015901 4,0977673 0,0273532 0,29454674 1815 100287166 LOC10028 uncharacterized -0,1719187 5,3245291 0,0273538 0,29454674 7166 LOC100287166 1816 677769 SCARNA17 small Cajal body- -0,4283564 5,3076239 0,0273777 0,29464186 specific RNA 17 1817 7084 TK2 thymidine kinase 2, 0,16586858 8,2945241 0,0273978 0,29469602 mitochondrial 1818 118788 PIK3AP1 phosphoinositide-3- 0,41785273 2,7057552 0,0274176 0,29474695 kinase adaptor protein 1 1819 64768 IPPK inositol 1,3,4,5,6- 0,07188953 2,5258507 0,0274636 0,29507892 pentakisphosphate 2- kinase 1820 196 AHR aryl hydrocarbon 0,29460236 11,034395 0,0274793 0,2950849 receptor 1821 25941 TPGS2 tubulin 0,22009192 9,486747 0,0275821 0,29590484 polyglutamylase complex subunit 2 1822 2314 FLII flightless I homolog -0,112081 9,5775202 0,0275859 0,29590484 (Drosophila) 1823 51479 ANKFY1 ankyrin repeat and 0,14643605 6,9207947 0,0276028 0,29592422 FYVE domain containing 1 1824 135112 NCOA7 nuclear receptor 0,25284098 11,097377 0,0276486 0,29595689 coactivator 7 1825 10247 HRSP12 heat-responsive -0,188928 10,514792 0,0276498 0,29595689 protein 12 1826 65010 SLC26A6 solute carrier family 26 -0,1281369 2,5853514 0,0276513 0,29595689 (anion exchanger), member 6

1827 5641 LGMN legumain 0,4778868 9,6377436 0,0276731 0,29602756 1828 101927279 LOC10192 uncharacterized -0,0552186 2,2032905 0,027757 0,29659716 7279 LOC101927279 1829 23588 KLHDC2 kelch domain -0,0905125 11,589379 0,0277714 0,29659716 containing 2 1830 24145 PANX1 pannexin 1 0,27580619 6,1890179 0,0277718 0,29659716 1831 4318 MMP9 matrix 0,87072924 6,5378731 0,0278708 0,2971316 metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) 1832 57556 SEMA6A sema domain, 0,15928544 4,3781273 0,0278857 0,2971316 transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A

1833 51752 ERAP1 endoplasmic reticulum 0,15819595 9,6277906 0,0279318 0,2971316 aminopeptidase 1

1834 219347 TMEM254- TMEM254 antisense 0,15746834 2,3538473 0,0279413 0,2971316 AS1 RNA 1 1835 81839 VANGL1 VANGL planar cell 0,08515488 4,2379902 0,027946 0,2971316 polarity protein 1 1836 6678 SPARC secreted protein, 0,14620547 14,928223 0,0279635 0,2971316 acidic, cysteine-rich (osteonectin) 1837 25949 SYF2 SYF2 pre-mRNA- -0,0770233 10,303162 0,027981 0,2971316 splicing factor 1838 11214 AKAP13 A kinase (PRKA) anchor 0,17131873 7,0879383 0,0279923 0,2971316 protein 13 1839 84792 FAM220A family with sequence 0,15529376 9,7495483 0,0280132 0,2971316 similarity 220, member A 1840 80146 UXS1 UDP-glucuronate 0,18941911 8,3771044 0,0280158 0,2971316 decarboxylase 1 1841 5052 PRDX1 peroxiredoxin 1 0,0924543 11,812207 0,0280222 0,2971316 1842 1281 COL3A1 collagen, type III, alpha 0,2989746 14,488131 0,028024 0,2971316 1 1843 23534 TNPO3 transportin 3 -0,0808531 8,7077132 0,028024 0,2971316 1844 7629 ZNF76 zinc finger protein 76 -0,1473187 4,3512039 0,0280444 0,2971316

1845 266812 NAP1L5 nucleosome assembly 0,19134302 8,3704753 0,0280499 0,2971316 protein 1-like 5

1846 10106 CTDSP2 CTD (carboxy-terminal -0,269855 6,8813528 0,0280747 0,29714392 domain, RNA polymerase II, polypeptide A) small phosphatase 2 1847 10946 SF3A3 splicing factor 3a, -0,2118275 8,1499309 0,0280935 0,29714392 subunit 3, 60kDa 1848 10370 CITED2 Cbp/p300-interacting -0,2556016 10,738792 0,0281383 0,29714392 transactivator, with Glu/Asp-rich carboxy- terminal domain, 2

1849 8682 PEA15 phosphoprotein 0,22401784 11,216453 0,0281484 0,29714392 enriched in astrocytes 15 1850 60491 NIF3L1 NIF3 NGG1 interacting 0,11039035 8,0052789 0,0281611 0,29714392 factor 3-like 1 (S. cerevisiae) 1851 10417 SPON2 spondin 2, 0,34735097 8,3118256 0,0281662 0,29714392 extracellular matrix protein 1852 283464 GXYLT1 glucoside 0,18604761 3,9324902 0,0281664 0,29714392 xylosyltransferase 1 1853 6781 STC1 stanniocalcin 1 0,61538813 5,7231253 0,0281925 0,29714392 1854 4332 MNDA myeloid cell nuclear 1,05406859 5,6975507 0,0282009 0,29714392 differentiation antigen

1855 162962 ZNF836 zinc finger protein 836 -0,5775449 3,6784604 0,028205 0,29714392

1856 9093 DNAJA3 DnaJ (Hsp40) homolog, -0,1602219 7,9906396 0,0282183 0,29714392 subfamily A, member 3

1857 5707 PSMD1 proteasome (prosome, 0,18158104 10,29146 0,0282998 0,29766475 macropain) 26S subunit, non-ATPase, 1

1858 101927597 NCK1-AS1 NCK1 antisense RNA 1 0,30152682 6,3525362 0,0283352 0,29766475 (head to head) 1859 6505 SLC1A1 solute carrier family 1 0,11524495 2,8404321 0,0283413 0,29766475 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1

1860 22903 BTBD3 BTB (POZ) domain 0,20119096 8,5184584 0,0283552 0,29766475 containing 3 1861 2010 EMD emerin -0,1561213 8,2837515 0,028356 0,29766475 1862 1200 TPP1 tripeptidyl peptidase I 0,1864193 8,3003195 0,0283736 0,29766475

1863 56648 EIF5A2 eukaryotic translation 0,29811256 4,1218067 0,0283744 0,29766475 initiation factor 5A2

1864 5142 PDE4B phosphodiesterase 4B, 0,75716589 7,2272468 0,0284279 0,29779428 cAMP-specific 1865 79568 C2orf47 chromosome 2 open -0,1207462 9,6071159 0,0284333 0,29779428 reading frame 47

1866 6609 SMPD1 sphingomyelin 0,09927951 3,0746992 0,0284476 0,29779428 phosphodiesterase 1, acid lysosomal 1867 10609 LEPREL4 leprecan-like 4 -0,1248244 3,7107395 0,0284552 0,29779428 1868 26053 AUTS2 autism susceptibility -0,1395183 3,2978 0,0284629 0,29779428 candidate 2

1869 2069 EREG epiregulin 1,4546704 6,7211886 0,0285334 0,29803126 1870 8558 CDK10 cyclin-dependent -0,1557061 6,0240166 0,0285673 0,29803126 kinase 10 1871 125150 ZSWIM7 zinc finger, SWIM-type -0,1179274 6,6165835 0,0285732 0,29803126 containing 7 1872 253782 CERS6 ceramide synthase 6 -0,2458083 6,8453353 0,0285765 0,29803126

1873 85464 SSH2 slingshot protein 0,19839115 5,2977252 0,0285988 0,29803126 phosphatase 2 1874 8614 STC2 stanniocalcin 2 0,42087139 3,3824972 0,0286017 0,29803126 1875 166929 SGMS2 sphingomyelin 0,27412992 2,7150959 0,0286175 0,29803126 synthase 2 1876 54453 RIN2 Ras and Rab interactor 0,1843328 10,067401 0,0286205 0,29803126 2 1877 55000 TUG1 taurine up-regulated 1 0,1009193 8,7106528 0,0286228 0,29803126 (non-protein coding)

1878 54881 TEX10 testis expressed 10 -0,1897272 6,7638142 0,0286674 0,29812305 1879 93183 PIGM phosphatidylinositol 0,18887525 5,3523963 0,0286931 0,29812305 glycan anchor biosynthesis, class M 1880 4615 MYD88 myeloid differentiation 0,18585231 8,989279 0,0286973 0,29812305 primary response 88

1881 898 CCNE1 cyclin E1 -0,367693 4,8539283 0,0287069 0,29812305 1882 253832 ZDHHC20 zinc finger, DHHC-type 0,21458241 8,3285192 0,028714 0,29812305 containing 20 1883 56910 STARD7 StAR-related lipid 0,11692447 10,32765 0,0287232 0,29812305 transfer (START) domain containing 7 1884 100192378 ZFHX4-AS1 ZFHX4 antisense RNA 1 -0,5276668 4,4021903 0,0287611 0,29835842

1885 83473 KATNAL2 katanin p60 subunit A- 0,2529176 5,3693991 0,0288923 0,29947041 like 2 1886 26152 ZNF337 zinc finger protein 337 -0,1018906 6,1228468 0,028899 0,29947041

1887 5919 RARRES2 retinoic acid receptor -0,1877681 13,672445 0,0289562 0,29990455 responder (tazarotene induced) 2

1888 5571 PRKAG1 protein kinase, AMP- -0,174877 9,203618 0,0290356 0,30056787 activated, gamma 1 non-catalytic subunit

1889 22908 SACM1L SAC1 suppressor of 0,13039324 11,070653 0,0290906 0,30086301 actin mutations 1-like (yeast) 1890 2512 FTL ferritin, light 0,10185557 15,338264 0,0290949 0,30086301 polypeptide 1891 4351 MPI mannose phosphate -0,1363958 5,2440352 0,0291261 0,30088036 isomerase

1892 23403 FBXO46 F-box protein 46 -0,2504249 3,3676428 0,0291274 0,30088036 1893 5889 RAD51C RAD51 paralog C -0,1195204 6,4801592 0,0291787 0,30125153 1894 8605 PLA2G4C phospholipase A2, 0,36297455 4,2995952 0,0292786 0,30184106 group IVC (cytosolic, calcium-independent)

1895 79594 MUL1 mitochondrial E3 -0,2072703 6,1815356 0,0293293 0,30184106 ubiquitin protein ligase 1 1896 2193 FARSA phenylalanyl-tRNA -0,1579631 4,5203139 0,0293431 0,30184106 synthetase, alpha subunit 1897 65062 TMEM237 transmembrane 0,14906694 6,6790574 0,02936 0,30184106 protein 237 1898 7763 ZFAND5 zinc finger, AN1-type -0,2512669 12,843259 0,0293769 0,30184106 domain 5 1899 5315 PKM pyruvate kinase, 0,38574179 6,2683209 0,029381 0,30184106 muscle 1900 201134 CEP112 centrosomal protein 0,03850679 5,5554623 0,0293834 0,30184106 112kDa 1901 1535 CYBA cytochrome b-245, 0,36890417 9,3827124 0,0294138 0,30184106 alpha polypeptide 1902 57659 ZBTB4 zinc finger and BTB -0,1451499 10,938202 0,0294171 0,30184106 domain containing 4 1903 84572 GNPTG N-acetylglucosamine-1- -0,12041 8,5107379 0,0294237 0,30184106 phosphate transferase, gamma subunit

1904 130827 TMEM182 transmembrane 0,30460586 3,7676402 0,0294293 0,30184106 protein 182 1905 4925 NUCB2 nucleobindin 2 0,30068867 7,440787 0,0294351 0,30184106 1906 3654 IRAK1 interleukin-1 receptor- 0,20856315 6,6002426 0,0294762 0,30184106 associated kinase 1

1907 29780 PARVB parvin, beta -0,215711 4,350173 0,0294799 0,30184106 1908 55291 PPP6R3 protein phosphatase 6, -0,1309606 9,2668939 0,0294801 0,30184106 regulatory subunit 3

1909 2549 GAB1 GRB2-associated -0,2361704 6,9931589 0,0294972 0,30184106 binding protein 1 1910 494513 DFNB59 deafness, autosomal -0,3684386 5,4847976 0,0295059 0,30184106 recessive 59

1911 527 ATP6V0C ATPase, H+ -0,0980849 10,719348 0,0295199 0,30184106 transporting, lysosomal 16kDa, V0 subunit c 1912 7409 VAV1 vav 1 guanine 0,02392357 2,1783701 0,0295293 0,30184106 nucleotide exchange factor 1913 121274 ZNF641 zinc finger protein 641 -0,1576983 5,9036995 0,0295668 0,30192738

1914 9553 MRPL33 mitochondrial -0,092468 10,92232 0,0295686 0,30192738 ribosomal protein L33

1915 5468 PPARG peroxisome -0,2061516 11,9665 0,0296517 0,30257735 proliferator-activated receptor gamma

1916 85027 SMIM3 small integral -0,3095048 11,573373 0,0296632 0,30257735 membrane protein 3

1917 161742 SPRED1 sprouty-related, EVH1 0,28508343 6,7929775 0,0297082 0,30283456 domain containing 1

1918 50717 DCAF8 DDB1 and CUL4 -0,0731953 5,7860819 0,0297283 0,30283456 associated factor 8 1919 3300 DNAJB2 DnaJ (Hsp40) homolog, -0,3108531 6,0349614 0,0297417 0,30283456 subfamily B, member 2

1920 130916 MTERFD2 MTERF domain -0,0852261 5,8497135 0,0297504 0,30283456 containing 2 1921 6510 SLC1A5 solute carrier family 1 -0,1816816 9,7693653 0,0297799 0,30297725 (neutral amino acid transporter), member 5 1922 3200 HOXA3 homeobox A3 -0,1280521 4,9034285 0,0298297 0,30317332 1923 26503 SLC17A5 solute carrier family 17 0,17207593 7,4266326 0,029838 0,30317332 (acidic sugar transporter), member 5 1924 3725 JUN jun proto-oncogene -0,1262514 13,801002 0,0298458 0,30317332 1925 113201 CASC4 cancer susceptibility 0,12624671 12,796449 0,0298637 0,30319753 candidate 4

1926 5688 PSMA7 proteasome (prosome, -0,0691579 11,413035 0,0299481 0,30389744 macropain) subunit, alpha type, 7

1927 374819 LRRC37A3 leucine rich repeat -0,6252221 4,6405293 0,0300014 0,30427944 containing 37, member A3 1928 3240 HP haptoglobin 0,76849554 7,52769 0,0300872 0,30482801 1929 1639 DCTN1 dynactin 1 -0,1628939 6,987772 0,0301031 0,30482801 1930 81873 ARPC5L actin related protein 0,08938491 8,3495295 0,0301157 0,30482801 2/3 complex, subunit 5- like

1931 55081 IFT57 intraflagellar transport 0,15458069 5,489779 0,0301303 0,30482801 57 homolog (Chlamydomonas)

1932 51388 NIP7 NIP7, nucleolar pre- 0,12911351 7,9979451 0,0301334 0,30482801 rRNA processing protein 1933 5965 RECQL RecQ helicase-like 0,30136366 9,6347067 0,0301556 0,30489412 1934 8841 HDAC3 histone deacetylase 3 -0,1612434 7,7533304 0,0301964 0,30491772

1935 113510 HELQ helicase, POLQ-like -0,1681286 6,4669183 0,0301994 0,30491772 1936 55893 ZNF395 zinc finger protein 395 -0,2764583 6,9787739 0,0302047 0,30491772

1937 1778 DYNC1H1 dynein, cytoplasmic 1, 0,07222632 5,851123 0,0302535 0,30510966 heavy chain 1 1938 5589 PRKCSH protein kinase C -0,2073056 6,0745933 0,0302549 0,30510966 substrate 80K-H 1939 84164 ASCC2 activating signal -0,1379066 8,5869794 0,0302966 0,30516654 cointegrator 1 complex subunit 2 1940 6801 STRN striatin, calmodulin 0,09457895 5,2000408 0,0302967 0,30516654 binding protein 1941 6257 RXRB retinoid X receptor, -0,1323018 5,063061 0,0303164 0,30516654 beta 1942 22918 CD93 CD93 molecule 0,38412226 10,322818 0,0303351 0,30516654 1943 10675 CSPG5 chondroitin sulfate -0,1035631 3,0003 0,0303387 0,30516654 proteoglycan 5 (neuroglycan C) 1944 10531 PITRM1 pitrilysin -0,1069031 8,9249162 0,0303704 0,30522572 metallopeptidase 1 1945 84936 ZFYVE19 zinc finger, FYVE -0,1771456 4,2524593 0,030377 0,30522572 domain containing 19

1946 80314 EPC1 enhancer of polycomb -0,0882784 8,7335854 0,0303932 0,30522572 homolog 1 (Drosophila) 1947 79607 FAM118B family with sequence 0,19976471 6,0633823 0,0304405 0,30522572 similarity 118, member B 1948 8536 CAMK1 calcium/calmodulin- -0,2353262 8,3405041 0,030441 0,30522572 dependent protein kinase I 1949 10799 RPP40 ribonuclease P/MRP 0,33710607 5,2368503 0,0304468 0,30522572 40kDa subunit 1950 85461 TANC1 tetratricopeptide 0,16002145 9,2333748 0,0304539 0,30522572 repeat, ankyrin repeat and coiled-coil containing 1 1951 84717 HDGFRP2 hepatoma-derived -0,2260228 6,5632157 0,0304822 0,3053534 growth factor-related protein 2 1952 217 ALDH2 aldehyde -0,0893462 14,5656 0,0305173 0,30551676 dehydrogenase 2 family (mitochondrial)

1953 146050 ZSCAN29 zinc finger and SCAN 0,15260247 6,809564 0,0305298 0,30551676 domain containing 29

1954 3636 INPPL1 inositol polyphosphate -0,0924292 3,27233 0,0305547 0,30560952 phosphatase-like 1

1955 84888 SPPL2A signal peptide 0,15910554 9,3076179 0,0305707 0,30561344 peptidase like 2A 1956 6573 SLC19A1 solute carrier family 19 -0,0858197 2,7193287 0,0306308 0,30605778 (folate transporter), member 1 1957 8721 EDF1 endothelial -0,1513956 11,047293 0,0307226 0,30671862 differentiation-related factor 1 1958 10490 VTI1B vesicle transport 0,12240342 10,218763 0,0307284 0,30671862 through interaction with t-SNAREs 1B 1959 729991 MEF2BNB MEF2B neighbor -0,0756451 5,128714 0,0307575 0,30685283 1960 894 CCND2 cyclin D2 0,28108688 7,099264 0,030802 0,30714026 1961 3400 ID4 inhibitor of DNA 0,3629659 10,004847 0,0308308 0,30727019 binding 4, dominant negative helix-loop- helix protein 1962 4739 NEDD9 neural precursor cell 0,19246728 7,7409476 0,0308776 0,30758023 expressed, developmentally down- regulated 9 1963 4074 M6PR mannose-6-phosphate 0,27491203 7,4635589 0,0309478 0,30810927 receptor (cation dependent) 1964 55186 SLC25A36 solute carrier family 25 -0,0822161 9,5944834 0,0309623 0,30810927 (pyrimidine nucleotide carrier ), member 36

1965 28999 KLF15 Kruppel-like factor 15 -0,2546664 6,7328248 0,0309786 0,30811483

1966 403 ARL3 ADP-ribosylation -0,1142016 3,7410774 0,0310186 0,30821317 factor-like 3 1967 857 CAV1 caveolin 1, caveolae 0,06690501 14,759611 0,0310302 0,30821317 protein, 22kDa 1968 3619 INCENP inner centromere 0,02237368 2,1779632 0,0310358 0,30821317 protein antigens 135/155kDa 1969 8443 GNPAT glyceronephosphate O- -0,1231798 10,336354 0,0311072 0,30874589 acyltransferase 1970 7314 UBB ubiquitin B -0,0780592 15,085129 0,0311428 0,30874589 1971 596 BCL2 B-cell CLL/lymphoma 2 -0,1156561 6,8633745 0,0311471 0,30874589

1972 4047 LSS lanosterol synthase -0,4183064 7,0835307 0,0311526 0,30874589 (2,3-oxidosqualene- lanosterol cyclase) 1973 285282 RABL3 RAB, member of RAS 0,14569385 8,2491517 0,0311917 0,30897657 oncogene family-like 3

1974 57863 CADM3 cell adhesion molecule 0,41321788 4,813596 0,0312246 0,30902107 3 1975 79065 ATG9A autophagy related 9A -0,177188 8,0156028 0,0312375 0,30902107

1976 3093 UBE2K ubiquitin-conjugating 0,13853252 9,267449 0,03125 0,30902107 enzyme E2K 1977 255919 CNEP1R1 CTD nuclear envelope 0,14731817 8,5849529 0,0312742 0,30902107 phosphatase 1 regulatory subunit 1

1978 81844 TRIM56 tripartite motif 0,1538136 7,0030819 0,0312753 0,30902107 containing 56 1979 5204 PFDN5 prefoldin subunit 5 -0,1604411 12,576538 0,0313114 0,30922189 1980 400410 ST20 suppressor of -0,0104424 2,177119 0,03136 0,30948191 tumorigenicity 20 1981 3911 LAMA5 laminin, alpha 5 0,18633209 7,3361028 0,0313694 0,30948191 1982 23580 CDC42EP4 CDC42 effector protein -0,2580125 8,384656 0,0314072 0,30969854 (Rho GTPase binding) 4

1983 51184 GPN3 GPN-loop GTPase 3 -0,1603656 9,7977286 0,0314315 0,30978222 1984 10203 CALCRL calcitonin receptor-like -0,3215151 8,3564842 0,0314949 0,31022806

1985 23625 FAM89B family with sequence -0,1211846 8,7563149 0,0315085 0,31022806 similarity 89, member B 1986 27145 FILIP1 filamin A interacting 0,37372086 4,0552625 0,0316474 0,31103782 protein 1

1987 10352 WARS2 tryptophanyl tRNA -0,219985 6,735066 0,0316553 0,31103782 synthetase 2, mitochondrial 1988 160335 TMTC2 transmembrane and 0,21386348 4,7015409 0,0316723 0,31103782 tetratricopeptide repeat containing 2 1989 55269 PSPC1 paraspeckle -0,1169129 6,6978511 0,031695 0,31103782 component 1 1990 57171 DOLPP1 dolichyldiphosphatase -0,0702151 4,7837621 0,0317154 0,31103782 1 1991 90874 ZNF697 zinc finger protein 697 0,13428548 5,9165346 0,0317225 0,31103782

1992 56122 PCDHB14 protocadherin beta 14 0,31237973 5,8438663 0,0317253 0,31103782

1993 78994 PRR14 proline rich 14 -0,1118856 3,7823953 0,0317538 0,31103782 1994 51606 ATP6V1H ATPase, H+ -0,0887679 9,1506574 0,0317602 0,31103782 transporting, lysosomal 50/57kDa, V1 subunit H

1995 5260 PHKG1 phosphorylase kinase, -0,4188112 3,9942672 0,0317604 0,31103782 gamma 1 (muscle)

1996 55034 MOCOS molybdenum cofactor -0,6144072 4,7761556 0,0317726 0,31103782 sulfurase 1997 27034 ACAD8 acyl-CoA -0,211364 8,2203398 0,0317901 0,31103782 dehydrogenase family, member 8 1998 337876 CHSY3 chondroitin sulfate 0,44498926 5,2634019 0,0317977 0,31103782 synthase 3 1999 83594 NUDT12 nudix (nucleoside 0,27650301 7,6112229 0,0318161 0,31106285 diphosphate linked moiety X)-type motif 12 2000 3557 IL1RN interleukin 1 receptor 0,55644577 3,9823921 0,0318355 0,31109618 antagonist 2001 79633 FAT4 FAT atypical cadherin 4 0,42394832 6,7417772 0,0318785 0,31119334

2002 101929480 LOC10192 uncharacterized -0,1137694 2,2575537 0,0318896 0,31119334 9480 LOC101929480 2003 6884 TAF13 TAF13 RNA 0,80945416 5,0012231 0,0319011 0,31119334 polymerase II, TATA box binding protein (TBP)-associated factor, 18kDa 2004 51714 SELT selenoprotein T 0,11243009 10,52852 0,031914 0,31119334 2005 23144 ZC3H3 zinc finger CCCH-type -0,0803407 3,8639437 0,0319381 0,31119334 containing 3 2006 5431 POLR2B polymerase (RNA) II 0,0734264 11,108447 0,0319425 0,31119334 (DNA directed) polypeptide B, 140kDa

2007 157769 FAM91A1 family with sequence 0,18816271 8,3726572 0,0319569 0,31119334 similarity 91, member A1 2008 1982 EIF4G2 eukaryotic translation 0,07994639 13,132277 0,0319962 0,31142086 initiation factor 4 gamma, 2

2009 3927 LASP1 LIM and SH3 protein 1 0,14398233 11,661868 0,0320734 0,31200803

2010 80022 MYO15B myosin XVB -0,0856678 4,5266022 0,0320884 0,31200803 pseudogene 2011 57552 NCEH1 neutral cholesterol 0,80985292 5,625967 0,0321392 0,31214465 ester hydrolase 1 2012 5250 SLC25A3 solute carrier family 25 -0,0815356 13,546657 0,0321485 0,31214465 (mitochondrial carrier; phosphate carrier), member 3 2013 2696 GIPR gastric inhibitory -0,0209286 2,2635378 0,0321504 0,31214465 polypeptide receptor

2014 84844 PHF5A PHD finger protein 5A -0,1139663 9,0570486 0,032248 0,31293669

2015 9382 COG1 component of -0,093695 7,6507668 0,0322863 0,31315304 oligomeric golgi complex 1 2016 9967 THRAP3 thyroid hormone -0,1416857 6,5317566 0,0324705 0,31442785 receptor associated protein 3 2017 285830 HLA-F-AS1 HLA-F antisense RNA 1 -0,2705413 9,0247444 0,0324929 0,31442785

2018 7832 BTG2 BTG family, member 2 -0,1774589 11,17465 0,0324989 0,31442785

2019 8427 ZNF282 zinc finger protein 282 -0,1568149 3,5910042 0,0325222 0,31442785

2020 10491 CRTAP cartilage associated 0,13544644 11,049747 0,0325298 0,31442785 protein 2021 23203 PMPCA peptidase -0,1420471 7,2634302 0,0325364 0,31442785 (mitochondrial processing) alpha 2022 51726 DNAJB11 DnaJ (Hsp40) homolog, 0,12826922 9,4364467 0,0325433 0,31442785 subfamily B, member 11 2023 84971 ATG4D autophagy related 4D, -0,1644746 2,9416708 0,0325464 0,31442785 cysteine peptidase

2024 3799 KIF5B kinesin family member 0,20629356 11,684259 0,0325839 0,31463423 5B 2025 56101 PCDHGB5 protocadherin gamma -0,1091212 2,4890471 0,0326077 0,31470838 subfamily B, 5

2026 3487 IGFBP4 insulin-like growth -0,5401046 8,8102482 0,0327096 0,31553579 factor binding protein 4 2027 55681 SCYL2 SCY1-like 2 (S. 0,15169188 9,5830778 0,032731 0,31558671 cerevisiae) 2028 51263 MRPL30 mitochondrial -0,1504456 7,8320373 0,0328205 0,31629402 ribosomal protein L30

2029 128553 TSHZ2 teashirt zinc finger 0,26007056 6,620446 0,0328425 0,31634977 homeobox 2 2030 203068 TUBB tubulin, beta class I -0,1755266 11,346127 0,0329121 0,31658159 2031 54923 LIME1 Lck interacting -0,1485874 3,3028639 0,0329244 0,31658159 transmembrane adaptor 1 2032 84938 ATG4C autophagy related 4C, 0,20307915 6,795571 0,0329284 0,31658159 cysteine peptidase

2033 645212 EIF3J-AS1 EIF3J antisense RNA 1 -0,1390406 5,5672777 0,0329314 0,31658159 (head to head) 2034 1416 CRYBB2P1 crystallin, beta B2 0,35301918 4,3346502 0,0329519 0,31662304 pseudogene 1 2035 3551 IKBKB inhibitor of kappa light 0,12576314 4,6429053 0,0329892 0,31682646 polypeptide gene enhancer in B-cells, kinase beta 2036 113146 AHNAK2 AHNAK nucleoprotein 0,31327821 2,8699812 0,0330318 0,31707906 2 2037 219333 USP12 ubiquitin specific 0,29958832 6,6403007 0,0331255 0,31762284 peptidase 12 2038 2537 IFI6 interferon, alpha- 0,59261968 8,8291034 0,0331356 0,31762284 inducible protein 6 2039 25903 OLFML2B olfactomedin-like 2B 0,67899112 6,9853944 0,0331372 0,31762284

2040 85025 TMEM60 transmembrane 0,07189128 8,5704245 0,0332149 0,31821189 protein 60 2041 202781 PAXIP1- PAXIP1 antisense RNA -0,1792424 8,3428583 0,0332866 0,31864593 AS1 1 (head to head)

2042 54476 RNF216 ring finger protein 216 -0,0581659 6,0722695 0,0333055 0,31864593

2043 10129 FRY furry homolog 0,27136349 7,0676616 0,0333091 0,31864593 (Drosophila) 2044 23131 GPATCH8 G patch domain -0,1754157 7,7914241 0,0333654 0,31902814 containing 8 2045 9743 ARHGAP32 Rho GTPase activating -0,2706224 4,6930723 0,0334406 0,31959082 protein 32

2046 9521 EEF1E1 eukaryotic translation 0,30061 7,730401 0,0334796 0,31960011 elongation factor 1 epsilon 1

2047 6586 SLIT3 slit homolog 3 0,21324974 8,5641477 0,0334861 0,31960011 (Drosophila) 2048 6752 SSTR2 somatostatin receptor -0,3880522 3,4241663 0,0334933 0,31960011 2 2049 100996457 LOC10099 uncharacterized -0,2344355 2,289513 0,033507 0,31960011 6457 LOC100996457 2050 11329 STK38 serine/threonine 0,16244504 7,6706767 0,0335891 0,32016049 kinase 38 2051 83888 FGFBP2 fibroblast growth -0,9866075 7,0957211 0,0336033 0,32016049 factor binding protein 2 2052 93556 EGFEM1P EGF-like and EMI -0,0922516 2,2157422 0,0336203 0,32016049 domain containing 1, pseudogene 2053 3831 KLC1 kinesin light chain 1 0,01819363 6,300859 0,0336313 0,32016049 2054 6838 SURF6 surfeit 6 -0,1857098 5,2185989 0,0336582 0,32020417 2055 55808 ST6GALNA ST6 (alpha-N-acetyl- 0,51377997 2,5509984 0,0336686 0,32020417 C1 neuraminyl-2,3-beta- galactosyl-1,3)-N- acetylgalactosaminide alpha-2,6- sialyltransferase 1 2056 10245 TIMM17B translocase of inner -0,0992932 6,498731 0,0337185 0,32052215 mitochondrial membrane 17 homolog B (yeast) 2057 81857 MED25 mediator complex -0,1701366 7,6805938 0,0338059 0,32119682 subunit 25 2058 2935 GSPT1 G1 to S phase 0,08507602 8,6613932 0,0338498 0,32145839 transition 1 2059 27229 TUBGCP4 tubulin, gamma -0,1753802 5,6799502 0,0338799 0,32158749 complex associated protein 4 2060 23034 SAMD4A sterile alpha motif 0,22252249 5,0186413 0,0339142 0,32175642 domain containing 4A

2061 5654 HTRA1 HtrA serine peptidase 0,24706964 12,029192 0,0339344 0,32177228 1 2062 1389 CREBL2 cAMP responsive 0,07770376 10,293657 0,0339635 0,32177228 element binding protein-like 2 2063 4069 LYZ lysozyme 1,15277736 9,0974857 0,0339652 0,32177228 2064 4065 LY75 lymphocyte antigen 75 0,57213819 3,5992558 0,0339967 0,3219143

2065 84126 ATRIP ATR interacting protein -0,036031 2,3257821 0,0340649 0,32229528

2066 51337 THEM6 thioesterase -0,1911941 4,7814012 0,0340699 0,32229528 superfamily member 6

2067 5950 RBP4 retinol binding protein -0,0952552 14,687256 0,0341979 0,32320153 4, plasma 2068 101928412 LOC10192 uncharacterized -0,0081841 2,1701081 0,0342109 0,32320153 8412 LOC101928412 2069 6401 SELE selectin E 0,64340876 12,294893 0,0342153 0,32320153 2070 23327 NEDD4L neural precursor cell -0,1695944 7,1498911 0,0342448 0,32332368 expressed, developmentally down- regulated 4-like, E3 ubiquitin protein ligase

2071 83935 TMEM133 transmembrane 0,13810832 8,9413956 0,034316 0,3238395 protein 133 2072 1104 RCC1 regulator of -0,1514798 3,8035353 0,0343461 0,32384419 chromosome condensation 1 2073 144402 CPNE8 copine VIII 0,28437144 5,5737039 0,0343496 0,32384419 2074 23366 KIAA0895 KIAA0895 -0,3939292 3,195351 0,0343678 0,32385954 2075 23358 USP24 ubiquitin specific 0,15902844 8,5342371 0,0344029 0,32403394 peptidase 24 2076 81037 CLPTM1L CLPTM1-like 0,19593618 10,40385 0,0345307 0,32497019 2077 51593 SRRT serrate RNA effector -0,0961931 7,3451716 0,0345645 0,32497019 molecule homolog (Arabidopsis)

2078 1291 COL6A1 collagen, type VI, alpha 0,31063801 7,794204 0,0345779 0,32497019 1 2079 79954 NOL10 nucleolar protein 10 -0,0891984 7,5655327 0,0345819 0,32497019 2080 9734 HDAC9 histone deacetylase 9 -0,2154536 5,0384187 0,0345854 0,32497019

2081 151171 LINC01107 long intergenic non- -0,0754529 2,8308307 0,0346318 0,32524924 protein coding RNA 1107 2082 6424 SFRP4 secreted frizzled- 0,71608377 8,934143 0,0346898 0,32541158 related protein 4 2083 9330 GTF3C3 general transcription -0,104599 6,3683512 0,0346986 0,32541158 factor IIIC, polypeptide 3, 102kDa

2084 10973 ASCC3 activating signal 0,19294045 5,5246589 0,034699 0,32541158 cointegrator 1 complex subunit 3 2085 114791 TUBGCP5 tubulin, gamma 0,16696416 6,1304289 0,034793 0,32613666 complex associated protein 5 2086 1051 CEBPB CCAAT/enhancer -0,1273787 14,395371 0,0348333 0,32635762 binding protein (C/EBP), beta 2087 29967 LRP12 low density lipoprotein 0,26839576 5,3933903 0,0348506 0,32636327 receptor-related protein 12

2088 348180 CTU2 cytosolic thiouridylase 0,14822855 5,6544822 0,0348867 0,32654456 subunit 2 homolog (S. pombe)

2089 83742 MARVELD MARVEL domain 0,39651758 8,1570581 0,0349785 0,32711016 1 containing 1 2090 7358 UGDH UDP-glucose 6- 0,29891798 9,762615 0,0349806 0,32711016 dehydrogenase 2091 4939 OAS2 2'-5'-oligoadenylate 0,44215653 4,7011537 0,0351339 0,32815408 synthetase 2, 69/71kDa 2092 29108 PYCARD PYD and CARD domain 0,53045704 4,8732609 0,0351399 0,32815408 containing 2093 25793 FBXO7 F-box protein 7 -0,0866866 9,8386587 0,0351426 0,32815408 2094 604 BCL6 B-cell CLL/lymphoma 6 -0,1816744 10,102868 0,0352718 0,32907272 2095 23365 ARHGEF12 Rho guanine 0,03906242 4,5536452 0,0352746 0,32907272 nucleotide exchange factor (GEF) 12

2096 3491 CYR61 cysteine-rich, -0,276794 12,547486 0,0353202 0,32916459 angiogenic inducer, 61

2097 81035 COLEC12 collectin sub-family 0,71432054 7,9355065 0,0353203 0,32916459 member 12 2098 1846 DUSP4 dual specificity -0,5477214 10,14465 0,0353618 0,32916459 phosphatase 4 2099 169200 TMEM64 transmembrane 0,25828678 8,9595382 0,0353625 0,32916459 protein 64 2100 4212 MEIS2 Meis homeobox 2 -0,1749529 8,395156 0,0353687 0,32916459 2101 56927 GPR108 G protein-coupled -0,1668296 7,4573061 0,0354103 0,32926584 receptor 108 2102 100628315 DNM3OS DNM3 opposite 0,20796888 5,4329416 0,0354202 0,32926584 strand/antisense RNA

2103 339123 JMJD8 jumonji domain -0,1492588 5,8826036 0,0354934 0,32926584 containing 8 2104 5813 PURA purine-rich element 0,06856604 9,3855148 0,0354988 0,32926584 binding protein A 2105 50848 F11R F11 receptor 0,07796495 7,5936134 0,0355028 0,32926584 2106 3032 HADHB hydroxyacyl-CoA -0,1077949 12,85214 0,0355058 0,32926584 dehydrogenase/3- ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), beta subunit

2107 3437 IFIT3 interferon-induced 0,3535011 9,6671121 0,0355087 0,32926584 protein with tetratricopeptide repeats 3 2108 304 ANXA2P2 annexin A2 0,19252109 7,6288523 0,0355143 0,32926584 pseudogene 2 2109 7593 MZF1 myeloid zinc finger 1 -0,0769634 5,6830541 0,0355747 0,32966887

2110 10589 DRAP1 DR1-associated -0,1261651 8,558508 0,0357233 0,33088875 protein 1 (negative cofactor 2 alpha) 2111 51142 CHCHD2 coiled-coil-helix-coiled- -0,1083797 11,921077 0,035837 0,33178481 coil-helix domain containing 2 2112 8668 EIF3I eukaryotic translation -0,1110938 12,004781 0,0359615 0,33277994 initiation factor 3, subunit I 2113 55290 BRF2 BRF2, RNA polymerase -0,2308267 7,4765087 0,0359926 0,33290991 III transcription initiation factor 50 kDa subunit

2114 1347 COX7A2 cytochrome c oxidase -0,0977032 13,024113 0,0360227 0,3330313 subunit VIIa polypeptide 2 (liver)

2115 10396 ATP8A1 ATPase, 0,23378637 4,3731113 0,0360551 0,33317315 aminophospholipid transporter (APLT), class I, type 8A, member 1 2116 219743 TYSND1 trypsin domain -0,3417237 6,7478579 0,0360948 0,33326505 containing 1 2117 129293 TRABD2A TraB domain -0,2700166 4,4129731 0,0361143 0,33326505 containing 2A 2118 100289509 KCNIP2- KCNIP2 antisense RNA -0,0227084 2,2812609 0,0361162 0,33326505 AS1 1 2119 4209 MEF2D myocyte enhancer -0,0958034 4,7088104 0,0361696 0,33359465 factor 2D 2120 8334 HIST1H2A histone cluster 1, H2ac 0,37602587 9,0393834 0,036202 0,33359465 C 2121 384 ARG2 arginase 2 -0,1826882 4,2674787 0,0362184 0,33359465 2122 3845 KRAS Kirsten rat sarcoma 0,22194186 6,9731945 0,0362341 0,33359465 viral oncogene homolog 2123 9604 RNF14 ring finger protein 14 0,13926006 9,1585866 0,0362373 0,33359465

2124 26005 C2CD3 C2 calcium-dependent -0,0345159 4,6494061 0,0362615 0,33366047 domain containing 3

2125 5989 RFX1 regulatory factor X, 1 -0,0867988 4,0427836 0,0363407 0,33423138 (influences HLA class II expression) 2126 3586 IL10 interleukin 10 0,50513815 2,5390668 0,0363985 0,33460559 2127 7037 TFRC transferrin receptor 0,32468379 10,043502 0,0364259 0,33470001 2128 10484 SEC23A Sec23 homolog A (S. 0,1681663 11,956713 0,0364541 0,33480182 cerevisiae) 2129 5116 PCNT pericentrin -0,0663202 6,5596661 0,036481 0,33484029 2130 5597 MAPK6 mitogen-activated 0,20275105 8,9235357 0,0364925 0,33484029 protein kinase 6 2131 122773 KLHDC1 kelch domain -0,1426843 6,2119177 0,0365657 0,33492047 containing 1 2132 54206 ERRFI1 ERBB receptor -0,3020747 11,899421 0,0365771 0,33492047 feedback inhibitor 1 2133 1646 AKR1C2 aldo-keto reductase 0,1192623 14,130484 0,0365772 0,33492047 family 1, member C2 2134 55783 CMTR2 cap methyltransferase 0,16208085 8,7524755 0,0366213 0,33492047 2 2135 7329 UBE2I ubiquitin-conjugating -0,0642847 7,4987338 0,0366405 0,33492047 enzyme E2I

2136 64318 NOC3L nucleolar complex 0,12775307 8,0462371 0,0366669 0,33492047 associated 3 homolog (S. cerevisiae)

2137 55840 EAF2 ELL associated factor 2 0,20805726 5,3336669 0,0366924 0,33492047

2138 6633 SNRPD2 small nuclear -0,1473556 11,81435 0,0366996 0,33492047 ribonucleoprotein D2 polypeptide 16.5kDa

2139 90355 C5orf30 chromosome 5 open -0,6686943 10,000456 0,0367076 0,33492047 reading frame 30

2140 148479 PHF13 PHD finger protein 13 -0,2061902 9,6025039 0,03671 0,33492047

2141 100128893 GATA6- GATA6 antisense RNA -0,4938525 4,6891361 0,0367106 0,33492047 AS1 1 (head to head)

2142 23385 NCSTN nicastrin 0,16619337 6,9509043 0,0367149 0,33492047 2143 80325 ABTB1 ankyrin repeat and -0,118945 4,2782167 0,0367369 0,33492047 BTB (POZ) domain containing 1 2144 54906 FAM208B family with sequence 0,08971942 7,4009849 0,0367412 0,33492047 similarity 208, member B 2145 340277 FAM221A family with sequence -0,4407474 6,8567461 0,0367595 0,33493138 similarity 221, member A 2146 2355 FOSL2 FOS-like antigen 2 -0,1795332 6,7599099 0,0367776 0,3349403 2147 3140 MR1 major 0,13478205 4,5085316 0,0368171 0,33500974 histocompatibility complex, class I- related 2148 26037 SIPA1L1 signal-induced 0,24178751 4,8004376 0,0368195 0,33500974 proliferation- associated 1 like 1 2149 2802 GOLGA3 golgin A3 0,16188202 7,2444913 0,0368409 0,33503594 2150 57570 TRMT5 tRNA -0,094313 7,5171937 0,0368567 0,33503594 methyltransferase 5 2151 51686 OAZ3 ornithine -0,1717803 2,2693777 0,036975 0,33595546 decarboxylase antizyme 3 2152 2617 GARS glycyl-tRNA synthetase 0,16747051 10,227488 0,0370028 0,33605107

2153 8502 PKP4 plakophilin 4 0,13236696 8,7288457 0,0370364 0,33616783 2154 7107 GPR137B G protein-coupled 0,80449793 7,5276058 0,03705 0,33616783 receptor 137B 2155 7076 TIMP1 TIMP metallopeptidase 0,78013169 9,0526645 0,0371285 0,33672377 inhibitor 1

2156 57474 ZNF490 zinc finger protein 490 -0,3222574 3,7574745 0,0371608 0,33678387

2157 8690 JRKL jerky homolog-like 0,22486187 7,6265694 0,0371696 0,33678387 (mouse) 2158 5602 MAPK10 mitogen-activated -0,1514906 5,3447103 0,0372135 0,33702496 protein kinase 10 2159 127396 ZNF684 zinc finger protein 684 0,07396274 2,2856724 0,0372345 0,33705904

2160 100505812 LOC10050 uncharacterized 0,26864624 6,1840244 0,0372963 0,33746261 5812 LOC100505812 2161 5253 PHF2 PHD finger protein 2 -0,1330737 8,4636111 0,0373511 0,33780222 2162 25906 ANAPC15 anaphase promoting -0,2125605 8,1370077 0,0374035 0,33784642 complex subunit 15

2163 221294 NT5DC1 5'-nucleotidase -0,1091194 9,1347334 0,0374292 0,33784642 domain containing 1 2164 54809 SAMD9 sterile alpha motif 0,34421569 4,1078148 0,0374304 0,33784642 domain containing 9 2165 355 FAS Fas cell surface death 0,35221804 6,6355802 0,03744 0,33784642 receptor 2166 26284 ERAL1 Era-like 12S -0,1244033 4,6200751 0,0374425 0,33784642 mitochondrial rRNA chaperone 1 2167 4773 NFATC2 nuclear factor of 0,23683772 4,2821743 0,0375371 0,33850811 activated T-cells, cytoplasmic, calcineurin-dependent 2 2168 51592 TRIM33 tripartite motif -0,136887 8,2029467 0,0375504 0,33850811 containing 33 2169 4898 NRD1 nardilysin (N-arginine -0,1117568 10,75886 0,0375825 0,33864109 dibasic convertase)

2170 8867 SYNJ1 synaptojanin 1 0,05367872 3,9198847 0,0376442 0,33896421 2171 8578 SCARF1 scavenger receptor 0,14769683 6,1992245 0,0376531 0,33896421 class F, member 1 2172 7024 TFCP2 transcription factor 0,0979007 7,0697773 0,0378146 0,34026142 CP2 2173 64756 ATPAF1 ATP synthase -0,2093218 11,188888 0,0378726 0,34038882 mitochondrial F1 complex assembly factor 1 2174 56986 DTWD1 DTW domain -0,1086469 7,7035158 0,0378796 0,34038882 containing 1 2175 6478 SIAH2 siah E3 ubiquitin -0,1493647 8,207553 0,037881 0,34038882 protein ligase 2 2176 7289 TULP3 tubby like protein 3 -0,2208325 7,2456547 0,0379163 0,34047952 2177 79751 SLC25A22 solute carrier family 25 -0,1178655 5,754692 0,0379259 0,34047952 (mitochondrial carrier: glutamate), member 22 2178 6747 SSR3 signal sequence -0,0736753 9,3988368 0,0380459 0,34131934 receptor, gamma (translocon-associated protein gamma)

2179 55593 OTUD5 OTU deubiquitinase 5 -0,0941618 6,0733318 0,0380544 0,34131934

2180 55174 INTS10 integrator complex -0,1401028 9,676431 0,0381403 0,34193309 subunit 10 2181 84153 RNASEH2C ribonuclease H2, -0,1196787 6,3080083 0,0381853 0,34217931 subunit C 2182 1271 CNTFR ciliary neurotrophic -0,1638524 4,6143029 0,03824 0,34242293 factor receptor 2183 9124 PDLIM1 PDZ and LIM domain 1 0,2736989 10,647516 0,0382641 0,34242293

2184 401491 VLDLR-AS1 VLDLR antisense RNA 1 0,548118 7,1210148 0,038265 0,34242293

2185 54790 TET2 tet methylcytosine 0,09520785 5,7750174 0,0383654 0,34316136 dioxygenase 2 2186 100506844 RP11- uncharacterized -0,1703484 7,4268841 0,0383919 0,34316136 620J15.3 LOC100506844 2187 54847 SIDT1 SID1 transmembrane 0,11047584 2,2377602 0,0384002 0,34316136 family, member 1

2188 9818 NUPL1 nucleoporin like 1 0,24494788 5,6751378 0,0384183 0,3431656 2189 55647 RAB20 RAB20, member RAS -0,3447495 7,411712 0,0384443 0,34317597 oncogene family

2190 6612 SUMO3 small ubiquitin-like 0,10427035 9,9047749 0,0384545 0,34317597 modifier 3 2191 114987 WDR31 WD repeat domain 31 -0,0783669 2,6800909 0,0384774 0,34322324

2192 85477 SCIN scinderin 0,79882645 5,1303262 0,0385114 0,34336961 2193 7481 WNT11 wingless-type MMTV -0,323954 6,788157 0,0385547 0,34359901 integration site family, member 11

2194 54707 GPN2 GPN-loop GTPase 2 -0,3156536 7,3243962 0,0385827 0,3436409 2195 10226 PLIN3 perilipin 3 0,20468003 8,1738124 0,0385996 0,3436409 2196 5351 PLOD1 procollagen-lysine, 2- -0,258854 8,5049106 0,0386121 0,3436409 oxoglutarate 5- dioxygenase 1 2197 5328 PLAU plasminogen activator, 0,79329683 7,3773579 0,0386297 0,3436409 urokinase 2198 101060391 LOC10106 formin-like protein 16- -0,3623645 3,8647059 0,0387107 0,34420466 0391 like 2199 388882 AP000345. uncharacterized -0,0691724 2,2129682 0,0387905 0,344757 1 LOC388882 2200 9414 TJP2 tight junction protein 2 -0,0905023 6,5937869 0,0388357 0,34497699

2201 60314 C12orf10 chromosome 12 open -0,2512553 7,4414194 0,0388505 0,34497699 reading frame 10

2202 7070 THY1 Thy-1 cell surface 0,60797917 7,3332921 0,0388895 0,34505188 antigen 2203 29887 SNX10 sorting nexin 10 0,29117711 10,435347 0,0388943 0,34505188 2204 8694 DGAT1 diacylglycerol O- -0,2820798 10,175554 0,038937 0,34527409 acyltransferase 1 2205 552889 ATXN7L3B ataxin 7-like 3B -0,1076038 7,6830176 0,0389571 0,34529599

2206 60509 AGBL5 ATP/GTP binding -0,1435863 5,8926041 0,0389812 0,34535274 protein-like 5 2207 4919 ROR1 receptor tyrosine 0,21864362 4,3770811 0,0390204 0,34541615 kinase-like orphan receptor 1 2208 7837 PXDN peroxidasin homolog -0,136021 11,671162 0,0390245 0,34541615 (Drosophila)

2209 727 C5 complement -0,4854849 5,5832024 0,0390414 0,34541615 component 5 2210 340526 RGAG4 retrotransposon gag -0,1821546 6,637405 0,0390711 0,34552307 domain containing 4 2211 5552 SRGN serglycin 0,51548491 11,9713 0,0391217 0,34553911 2212 140609 NEK7 NIMA-related kinase 7 0,16433069 13,482316 0,0391536 0,34553911

2213 54148 MRPL39 mitochondrial -0,1287638 8,8456103 0,0391687 0,34553911 ribosomal protein L39

2214 151742 PPM1L protein phosphatase, 0,01666256 2,1861011 0,0391692 0,34553911 Mg2+/Mn2+ dependent, 1L

2215 79673 ZNF329 zinc finger protein 329 -0,1204205 6,74746 0,0391888 0,34553911

2216 54799 MBTD1 mbt domain -0,1873772 6,5964564 0,0391903 0,34553911 containing 1 2217 114885 OSBPL11 oxysterol binding 0,24858739 8,6844377 0,0391967 0,34553911 protein-like 11 2218 4548 MTR 5- 0,20623596 7,8483246 0,0392198 0,34558681 methyltetrahydrofolat e-homocysteine methyltransferase 2219 8347 HIST1H2BC histone cluster 1, H2bc 0,51120011 3,8797304 0,0392692 0,34577403

2220 154807 VKORC1L1 vitamin K epoxide 0,19609025 10,843973 0,039291 0,34577403 reductase complex, subunit 1-like 1 2221 8527 DGKD diacylglycerol kinase, -0,1295528 7,0304157 0,0392941 0,34577403 delta 130kDa

2222 9403 SEP15 15 kDa selenoprotein 0,20832217 11,997697 0,039312 0,34577572

2223 493911 PHOSPHO phosphatase, orphan 2 -0,2473674 7,7136958 0,0393739 0,34616484 2 2224 55076 TMEM45A transmembrane 0,25417943 8,3172199 0,0394146 0,34636627 protein 45A 2225 10052 GJC1 gap junction protein, -0,168806 3,2185036 0,0394443 0,34641072 gamma 1, 45kDa

2226 23640 HSPBP1 HSPA (heat shock -0,1183397 5,5121259 0,039495 0,34641072 70kDa) binding protein, cytoplasmic cochaperone 1

2227 79643 CHMP6 charged multivesicular -0,2143631 5,7778883 0,0395093 0,34641072 body protein 6

2228 81542 TMX1 thioredoxin-related 0,12812441 9,4942313 0,0395133 0,34641072 transmembrane protein 1 2229 23609 MKRN2 makorin ring finger -0,086505 7,7654228 0,0395423 0,34641072 protein 2 2230 6046 BRD2 bromodomain -0,1916499 10,912872 0,0395453 0,34641072 containing 2 2231 23586 DDX58 DEAD (Asp-Glu-Ala- 0,24015103 6,436476 0,039546 0,34641072 Asp) box polypeptide 58 2232 22847 ZNF507 zinc finger protein 507 -0,0896184 6,5389901 0,0395648 0,34641072

2233 4967 OGDH oxoglutarate (alpha- -0,0873394 5,6179963 0,03964 0,34641072 ketoglutarate) dehydrogenase (lipoamide) 2234 221908 PPP1R35 protein phosphatase 1, -0,3117372 6,0174107 0,0396432 0,34641072 regulatory subunit 35

2235 128977 C22orf39 chromosome 22 open -0,1196245 8,8271027 0,039658 0,34641072 reading frame 39 2236 116988 AGAP3 ArfGAP with GTPase -0,1186536 4,9244358 0,0396641 0,34641072 domain, ankyrin repeat and PH domain 3 2237 100131187 TSTD1 thiosulfate -0,2906723 10,102223 0,0396745 0,34641072 sulfurtransferase (rhodanese)-like domain containing 1 2238 85462 FHDC1 FH2 domain containing -0,073726 2,2103749 0,0396782 0,34641072 1 2239 54102 CLIC6 chloride intracellular 0,46445789 5,7493292 0,0396898 0,34641072 channel 6

2240 6809 STX3 syntaxin 3 0,19792045 3,4074604 0,0397032 0,34641072 2241 4718 NDUFC2 NADH dehydrogenase -0,0486152 7,9345541 0,039763 0,34677754 (ubiquinone) 1, subcomplex unknown, 2, 14.5kDa

2242 10461 MERTK c-mer proto-oncogene 0,17265351 2,5325705 0,0397907 0,34686382 tyrosine kinase

2243 51524 TMEM138 transmembrane 0,23738713 8,9014139 0,0398094 0,34687275 protein 138 2244 158405 KIAA1958 KIAA1958 -0,3393189 3,1676176 0,0398828 0,34710978 2245 28231 SLCO4A1 solute carrier organic 0,35256158 4,0343342 0,0398887 0,34710978 anion transporter family, member 4A1

2246 84334 APOPT1 apoptogenic 1, -0,1381726 8,8137728 0,0398954 0,34710978 mitochondrial 2247 57419 SLC24A3 solute carrier family 24 0,24088947 10,290665 0,0399146 0,34710978 (sodium/potassium/cal cium exchanger), member 3

2248 58526 MID1IP1 MID1 interacting -0,1931566 7,8080093 0,0399422 0,34710978 protein 1 2249 221302 ZUFSP zinc finger with UFM1- 0,23439888 5,8471603 0,0399749 0,34710978 specific peptidase domain 2250 9203 ZMYM3 zinc finger, MYM-type -0,062714 3,9267584 0,0399767 0,34710978 3 2251 81553 FAM49A family with sequence 0,10926544 7,5289713 0,0400062 0,34710978 similarity 49, member A 2252 5660 PSAP prosaposin 0,20764587 12,974553 0,0400139 0,34710978 2253 366 AQP9 aquaporin 9 0,46080819 5,1549925 0,0400142 0,34710978 2254 63906 GPATCH3 G patch domain -0,2384824 3,1257601 0,0400504 0,3471663 containing 3 2255 80094 BIN3-IT1 BIN3 intronic -0,0355661 2,1857095 0,0400563 0,3471663 transcript 1 (non- protein coding) 2256 54780 NSMCE4A non-SMC element 4 0,10033308 10,251139 0,0400856 0,34726596 homolog A (S. cerevisiae) 2257 23032 USP33 ubiquitin specific 0,13848014 11,026152 0,0401597 0,34771265 peptidase 33 2258 25825 BACE2 beta-site APP-cleaving 0,25209117 5,8053344 0,0401727 0,34771265 enzyme 2 2259 2487 FRZB frizzled-related protein 0,63765511 4,5351517 0,0401989 0,34778582

2260 22827 PUF60 poly-U binding splicing -0,1584908 9,6687442 0,0402332 0,34792819 factor 60KDa

2261 1147 CHUK conserved helix-loop- 0,15920167 8,7502007 0,0402665 0,3480622 helix ubiquitous kinase

2262 9182 RASSF9 Ras association 0,37854491 2,5663531 0,0403 0,34819753 (RalGDS/AF-6) domain family (N-terminal) member 9 2263 84460 ZMAT1 zinc finger, matrin- -0,3064925 7,0465164 0,0403481 0,34845928 type 1 2264 5189 PEX1 peroxisomal -0,1112098 7,4846461 0,0404523 0,34920443 biogenesis factor 1 2265 55486 PARL presenilin associated, -0,1328034 9,5917576 0,0405662 0,34987505 rhomboid-like

2266 1848 DUSP6 dual specificity 0,32314313 11,368256 0,0405817 0,34987505 phosphatase 6 2267 10728 PTGES3 prostaglandin E -0,0810208 12,605191 0,0406104 0,34987505 synthase 3 (cytosolic)

2268 23408 SIRT5 sirtuin 5 -0,0879561 4,1071266 0,0406187 0,34987505 2269 54957 TXNL4B thioredoxin-like 4B -0,173104 4,4124812 0,0406194 0,34987505 2270 646450 ARIH2OS ariadne homolog 2 -0,2068822 3,3172828 0,040665 0,35011339 opposite strand 2271 114036 LINC00310 long intergenic non- -0,3694727 4,2245765 0,0406964 0,35022924 protein coding RNA 310 2272 10295 BCKDK branched chain -0,1817119 6,4224539 0,0407333 0,35031099 ketoacid dehydrogenase kinase

2273 290 ANPEP alanyl (membrane) 0,51714199 5,1603852 0,0407754 0,35031099 aminopeptidase 2274 26157 GIMAP2 GTPase, IMAP family 0,49757717 6,6540267 0,0408019 0,35031099 member 2 2275 8774 NAPG N-ethylmaleimide- 0,15587897 8,3570813 0,0408183 0,35031099 sensitive factor attachment protein, gamma 2276 284119 PTRF polymerase I and 0,19836888 11,793893 0,0408289 0,35031099 transcript release factor 2277 153339 TMEM167 transmembrane 0,10856475 11,350425 0,0408337 0,35031099 A protein 167A 2278 10970 CKAP4 cytoskeleton- 0,12413598 8,2904603 0,0408371 0,35031099 associated protein 4 2279 83606 GUCD1 guanylyl cyclase -0,1390517 9,9576959 0,0408654 0,35031099 domain containing 1 2280 55209 SETD5 SET domain containing -0,1671215 6,3092092 0,0408672 0,35031099 5 2281 26040 SETBP1 SET binding protein 1 0,26165988 7,005876 0,0409168 0,35058204

2282 123036 TC2N tandem C2 domains, -0,4150059 6,0008735 0,0409405 0,35063115 nuclear 2283 171023 ASXL1 additional sex combs -0,153556 6,998799 0,0409675 0,35070925 like 1 (Drosophila)

2284 9656 MDC1 mediator of DNA- -0,1368557 3,6079954 0,0409966 0,35080421 damage checkpoint 1

2285 3992 FADS1 fatty acid desaturase 1 -0,7464887 10,160948 0,0411141 0,35165624

2286 51614 ERGIC3 ERGIC and golgi 3 -0,1722735 9,7440122 0,0411986 0,3522249 2287 987 LRBA LPS-responsive vesicle 0,23861786 8,3247583 0,0412798 0,35276487 trafficking, beach and anchor containing

2288 6400 SEL1L sel-1 suppressor of lin- 0,15523236 6,3588755 0,0413118 0,35280547 12-like (C. elegans)

2289 8237 USP11 ubiquitin specific -0,1594683 7,8003743 0,0413207 0,35280547 peptidase 11 2290 23078 VWA8 von Willebrand factor -0,1480491 7,7009085 0,0413398 0,35281434 A domain containing 8

2291 58509 CACTIN cactin, spliceosome C -0,0269397 3,9284011 0,0413623 0,35285202 complex subunit 2292 29015 SLC43A3 solute carrier family 0,23920134 6,3083884 0,0414936 0,35360761 43, member 3 2293 56894 AGPAT3 1-acylglycerol-3- 0,12210938 7,6372992 0,0415052 0,35360761 phosphate O- acyltransferase 3 2294 29803 REPIN1 replication initiator 1 -0,1102729 5,905068 0,0415203 0,35360761

2295 9270 ITGB1BP1 integrin beta 1 binding 0,1083394 11,844473 0,041527 0,35360761 protein 1 2296 51023 MRPS18C mitochondrial -0,0443529 2,2367937 0,0415552 0,35360761 ribosomal protein S18C 2297 4238 MFAP3 microfibrillar- 0,12393285 5,2512213 0,0415675 0,35360761 associated protein 3 2298 126669 SHE Src homology 2 0,2174075 5,2215128 0,0415775 0,35360761 domain containing E 2299 7251 TSG101 tumor susceptibility -0,1048971 10,007775 0,041603 0,3536706 101 2300 148523 CIART circadian associated -0,4845339 5,9833217 0,0416364 0,35380077 repressor of transcription 2301 5001 ORC5 origin recognition -0,1030884 5,7884843 0,0416768 0,35397161 complex, subunit 5 2302 2769 GNA15 guanine nucleotide 0,2931968 3,5682755 0,0416997 0,35397161 binding protein (G protein), alpha 15 (Gq class) 2303 54930 HAUS4 HAUS augmin-like -0,1798673 8,5113563 0,0417108 0,35397161 complex, subunit 4 2304 51256 TBC1D7 TBC1 domain family, 0,16356261 6,2087332 0,0417317 0,35399492 member 7 2305 29766 TMOD3 tropomodulin 3 0,23141052 5,8089835 0,041839 0,35475129 (ubiquitous) 2306 55466 DNAJA4 DnaJ (Hsp40) homolog, -0,1081315 8,3639226 0,0418801 0,35482638 subfamily A, member 4

2307 285704 RGMB repulsive guidance -0,2538174 6,5806045 0,0418842 0,35482638 molecule family member b 2308 7704 ZBTB16 zinc finger and BTB -0,2636605 11,189021 0,0419714 0,35518145 domain containing 16

2309 84065 TMEM222 transmembrane -0,1260552 7,8250679 0,041975 0,35518145 protein 222 2310 157378 TMEM65 transmembrane 0,21650823 6,1317216 0,0419806 0,35518145 protein 65 2311 786 CACNG1 calcium channel, -0,0642153 2,8789428 0,0422455 0,3566435 voltage-dependent, gamma subunit 1 2312 79990 PLEKHH3 pleckstrin homology -0,0357781 2,3796583 0,0422462 0,3566435 domain containing, family H (with MyTH4 domain) member 3 2313 56256 SERTAD4 SERTA domain -0,3360079 4,2255088 0,0422562 0,3566435 containing 4 2314 124935 SLC43A2 solute carrier family 43 0,22012692 4,9424665 0,0422724 0,3566435 (amino acid system L transporter), member 2

2315 10076 PTPRU protein tyrosine -0,1047231 5,0837145 0,0423071 0,3566435 phosphatase, receptor type, U 2316 133022 TRAM1L1 translocation 0,29654468 2,9060602 0,0423121 0,3566435 associated membrane protein 1-like 1

2317 28474 IGHV1-2 immunoglobulin heavy 0,46652348 3,8301771 0,0423324 0,3566435 variable 1-2 2318 9701 PPP6R2 protein phosphatase 6, -0,1550902 5,6215959 0,0423391 0,3566435 regulatory subunit 2

2319 23285 KIAA1107 KIAA1107 -0,4366549 4,6979935 0,0423454 0,3566435 2320 3080 CFHR2 complement factor H- 0,24434514 3,9129231 0,0423457 0,3566435 related 2 2321 272 AMPD3 adenosine 0,092392 2,5149881 0,0423634 0,3566435 monophosphate deaminase 3 2322 3218 HOXB8 homeobox B8 -0,1511544 3,4666511 0,0423846 0,3566435 2323 3421 IDH3G isocitrate -0,1297966 8,4075553 0,0423906 0,3566435 dehydrogenase 3 (NAD+) gamma 2324 55062 WIPI1 WD repeat domain, 0,13889913 9,4962317 0,0425454 0,35779184 phosphoinositide interacting 1 2325 197407 ZNF48 zinc finger protein 48 -0,1024147 6,1409918 0,0425723 0,35786365

2326 56922 MCCC1 methylcrotonoyl-CoA -0,2690713 9,9352283 0,0426128 0,35805009 carboxylase 1 (alpha)

2327 10985 GCN1L1 GCN1 general control -0,1269957 7,5330136 0,0426319 0,35805644 of amino-acid synthesis 1-like 1 (yeast) 2328 84282 RNF135 ring finger protein 135 -0,132491 9,4191661 0,0426553 0,35809921

2329 51011 FAHD2A fumarylacetoacetate -0,1392214 6,7320395 0,0426843 0,35818855 hydrolase domain containing 2A 2330 8226 HDHD1 haloacid dehalogenase- 0,22504058 6,6871694 0,042722 0,35835127 like hydrolase domain containing 1 2331 22836 RHOBTB3 Rho-related BTB -0,1798609 11,845362 0,0427419 0,35836451 domain containing 3 2332 56947 MFF mitochondrial fission -0,0939602 9,8435957 0,0427994 0,35869283 factor 2333 79109 MAPKAP1 mitogen-activated 0,08444956 7,8341399 0,0428744 0,35909111 protein kinase associated protein 1 2334 131544 CRYBG3 beta-gamma crystallin -0,1850146 9,7905455 0,0428986 0,35909111 domain containing 3

2335 2247 FGF2 fibroblast growth -0,2733127 9,7899156 0,0429021 0,35909111 factor 2 (basic) 2336 23731 TMEM245 transmembrane 0,09054574 10,496169 0,0429927 0,35964492 protein 245 2337 440 ASNS asparagine synthetase 0,19907908 6,9138377 0,0430293 0,35964492 (glutamine- hydrolyzing)

2338 391712 TRIM61 tripartite motif -0,1274817 2,6934468 0,0430445 0,35964492 containing 61 2339 51380 CSAD cysteine sulfinic acid -0,2590589 5,5122525 0,0430556 0,35964492 decarboxylase 2340 58492 ZNF77 zinc finger protein 77 -0,0689826 2,8302359 0,0430602 0,35964492

2341 27141 CIDEB cell death-inducing -0,0581257 4,2878744 0,0431332 0,35970893 DFFA-like effector b 2342 6385 SDC4 syndecan 4 -0,3015742 8,6654561 0,0431482 0,35970893 2343 83592 AKR1E2 aldo-keto reductase -0,0225217 2,4526307 0,043169 0,35970893 family 1, member E2

2344 57146 TMEM159 transmembrane 0,33598845 8,3481017 0,0432183 0,35970893 protein 159 2345 5087 PBX1 pre-B-cell leukemia -0,0742769 9,7225504 0,0432218 0,35970893 homeobox 1 2346 6455 SH3GL1 SH3-domain GRB2-like -0,1680035 8,6407464 0,0432375 0,35970893 1 2347 29886 SNX8 sorting nexin 8 -0,1911249 4,1963967 0,0432432 0,35970893 2348 10956 OS9 osteosarcoma -0,0853256 9,1323341 0,0432782 0,35970893 amplified 9, endoplasmic reticulum lectin 2349 387 RHOA ras homolog family 0,16192759 13,183569 0,0432942 0,35970893 member A 2350 2017 CTTN cortactin 0,10028146 8,9138324 0,0433081 0,35970893 2351 79090 TRAPPC6A trafficking protein -0,2072427 6,8420165 0,0433167 0,35970893 particle complex 6A 2352 1936 EEF1D eukaryotic translation -0,2159637 12,092304 0,0433264 0,35970893 elongation factor 1 delta (guanine nucleotide exchange protein)

2353 23095 KIF1B kinesin family member 0,15590901 8,5779235 0,0433529 0,35970893 1B 2354 644246 KANSL1- KANSL1 antisense RNA -0,1566643 8,2496759 0,0433537 0,35970893 AS1 1 2355 3770 KCNJ14 potassium inwardly- -0,030389 2,1829571 0,0433623 0,35970893 rectifying channel, subfamily J, member 14 2356 3643 INSR insulin receptor -0,1976182 7,971874 0,0433758 0,35970893 2357 56952 PRTFDC1 phosphoribosyl 0,4728502 7,4126802 0,0433808 0,35970893 transferase domain containing 1 2358 3074 HEXB hexosaminidase B 0,14256419 11,22014 0,0434191 0,35974771 (beta polypeptide) 2359 2058 EPRS glutamyl-prolyl-tRNA 0,1427553 9,0973164 0,0434343 0,35974771 synthetase 2360 84277 DNAJC30 DnaJ (Hsp40) homolog, -0,1737685 7,0807598 0,0434407 0,35974771 subfamily C, member 30 2361 256691 MAMDC2 MAM domain 0,77822848 8,0162725 0,043468 0,35982188 containing 2 2362 10952 SEC61B Sec61 beta subunit 0,08828656 11,805532 0,0435457 0,36031191 2363 7917 BAG6 BCL2-associated -0,1925115 9,6255559 0,0436218 0,36061971 athanogene 6 2364 5787 PTPRB protein tyrosine 0,38271672 5,296178 0,0436543 0,36061971 phosphatase, receptor type, B 2365 2947 GSTM3 glutathione S- 0,15523309 7,0747458 0,0436637 0,36061971 transferase mu 3 (brain) 2366 389072 PLEKHM3 pleckstrin homology 0,14486259 8,5734422 0,0436716 0,36061971 domain containing, family M, member 3

2367 80208 SPG11 spastic paraplegia 11 -0,042182 5,4142503 0,0436751 0,36061971 (autosomal recessive)

2368 2308 FOXO1 forkhead box O1 -0,1928322 10,622063 0,0437361 0,36097079 2369 55737 VPS35 vacuolar protein -0,0783118 10,863242 0,043785 0,36122158 sorting 35 homolog (S. cerevisiae) 2370 64121 RRAGC Ras-related GTP -0,1604932 11,100012 0,0438439 0,36155508 binding C 2371 2921 CXCL3 chemokine (C-X-C 0,69867464 10,813058 0,0440185 0,36278433 motif) ligand 3 2372 3376 IARS isoleucyl-tRNA 0,12195415 10,80798 0,0440467 0,36278433 synthetase 2373 80135 RPF1 ribosome production -0,0676558 9,9905503 0,0440487 0,36278433 factor 1 homolog (S. cerevisiae)

2374 1977 EIF4E eukaryotic translation 0,12986878 8,3767148 0,044151 0,36334491 initiation factor 4E

2375 5782 PTPN12 protein tyrosine 0,18386812 9,0594014 0,0441546 0,36334491 phosphatase, non- receptor type 12 2376 10945 KDELR1 KDEL (Lys-Asp-Glu-Leu) -0,1635228 9,3403041 0,0441962 0,36334491 endoplasmic reticulum protein retention receptor 1 2377 4938 OAS1 2'-5'-oligoadenylate 0,41117069 5,7931255 0,0442272 0,36334491 synthetase 1, 40/46kDa 2378 3973 LHCGR luteinizing 0,60801135 4,3917739 0,044249 0,36334491 hormone/choriogonad otropin receptor 2379 1736 DKC1 dyskeratosis congenita 0,07220467 7,9341357 0,0442559 0,36334491 1, dyskerin

2380 94015 TTYH2 tweety family member 0,11595254 3,0298651 0,0442653 0,36334491 2 2381 80723 SLC35G2 solute carrier family -0,2013363 9,0308037 0,0442725 0,36334491 35, member G2 2382 83982 IFI27L2 interferon, alpha- 0,28981634 5,6699427 0,0442966 0,36334491 inducible protein 27- like 2 2383 51327 AHSP alpha hemoglobin -0,0190467 2,1759103 0,0443026 0,36334491 stabilizing protein 2384 51696 HECA headcase homolog -0,1547326 10,534246 0,0443433 0,36352584 (Drosophila) 2385 5412 UBL3 ubiquitin-like 3 0,13628577 10,665143 0,0445003 0,36437289 2386 6194 RPS6 ribosomal protein S6 -0,1133988 14,898667 0,0445162 0,36437289

2387 23545 ATP6V0A2 ATPase, H+ 0,03413839 2,8718509 0,0445198 0,36437289 transporting, lysosomal V0 subunit a2 2388 4697 NDUFA4 NADH dehydrogenase -0,1333762 12,103135 0,044559 0,36437289 (ubiquinone) 1 alpha subcomplex, 4, 9kDa 2389 23194 FBXL7 F-box and leucine-rich 0,20600888 7,8958587 0,0445619 0,36437289 repeat protein 7

2390 56940 DUSP22 dual specificity -0,1242708 9,8361966 0,0445683 0,36437289 phosphatase 22 2391 3981 LIG4 ligase IV, DNA, ATP- 0,18338043 6,8093358 0,0445771 0,36437289 dependent 2392 54662 TBC1D13 TBC1 domain family, -0,16431 6,8607229 0,0446109 0,36445533 member 13 2393 51172 NAGPA N-acetylglucosamine-1- -0,1601749 6,3313304 0,0446245 0,36445533 phosphodiester alpha- N- acetylglucosaminidase

2394 25842 ASF1A anti-silencing function 0,16028832 8,415188 0,0447019 0,36493455 1A histone chaperone

2395 6792 CDKL5 cyclin-dependent -0,0638905 4,1176622 0,0447566 0,36514619 kinase-like 5 2396 84901 NFATC2IP nuclear factor of -0,0848396 6,7202717 0,0447652 0,36514619 activated T-cells, cytoplasmic, calcineurin-dependent 2 interacting protein

2397 29126 CD274 CD274 molecule 0,27702323 3,0508312 0,0448014 0,36528567 2398 1340 COX6B1 cytochrome c oxidase -0,0938949 12,54543 0,0448196 0,36528567 subunit VIb polypeptide 1 (ubiquitous) 2399 6928 HNF1B HNF1 homeobox B -0,0632898 2,2351206 0,0448801 0,36547666 2400 117854 TRIM6 tripartite motif 0,37219232 8,0900942 0,0448984 0,36547666 containing 6 2401 11112 HIBADH 3-hydroxyisobutyrate -0,1516244 11,209905 0,0449126 0,36547666 dehydrogenase

2402 10555 AGPAT2 1-acylglycerol-3- -0,1604531 11,977708 0,0449179 0,36547666 phosphate O- acyltransferase 2 2403 51101 ZC2HC1A zinc finger, C2HC-type -0,3302294 6,8448165 0,0449678 0,36557898 containing 1A 2404 11163 NUDT4 nudix (nucleoside -0,2061572 8,1291955 0,0449785 0,36557898 diphosphate linked moiety X)-type motif 4

2405 8638 OASL 2'-5'-oligoadenylate 0,27712208 5,2829612 0,0449866 0,36557898 synthetase-like 2406 10906 TRAFD1 TRAF-type zinc finger -0,0674783 4,9872281 0,045074 0,36598748 domain containing 1

2407 80328 ULBP2 UL16 binding protein 2 -0,1812422 2,436418 0,0450743 0,36598748

2408 84281 C2orf88 chromosome 2 open 0,39160776 4,0187132 0,0451644 0,36648976 reading frame 88

2409 4780 NFE2L2 nuclear factor, 0,20852 11,594611 0,0452216 0,36648976 erythroid 2-like 2 2410 144404 TMEM120 transmembrane -0,2227697 5,7721622 0,0452217 0,36648976 B protein 120B 2411 8732 RNGTT RNA 0,0729071 5,531204 0,0452298 0,36648976 guanylyltransferase and 5'-phosphatase 2412 29799 YPEL1 yippee-like 1 -0,0944899 2,9366528 0,0452481 0,36648976 (Drosophila) 2413 7128 TNFAIP3 tumor necrosis factor, 0,37695658 11,045345 0,0452487 0,36648976 alpha-induced protein 3 2414 643733 LOC64373 caspase 4, apoptosis- 0,30155181 7,377601 0,0453128 0,36667134 3 related cysteine peptidase pseudogene

2415 55974 SLC50A1 solute carrier family 50 -0,1481848 6,9453096 0,0453579 0,36667134 (sugar efflux transporter), member 1 2416 1052 CEBPD CCAAT/enhancer -0,2261566 13,819626 0,0453604 0,36667134 binding protein (C/EBP), delta 2417 9685 CLINT1 clathrin interactor 1 0,08418767 9,932243 0,0453808 0,36667134 2418 51347 TAOK3 TAO kinase 3 0,1015565 9,6131852 0,0453834 0,36667134 2419 28969 BZW2 basic leucine zipper -0,1651941 10,179905 0,0453836 0,36667134 and W2 domains 2 2420 51005 AMDHD2 amidohydrolase -0,2392232 2,7765073 0,0454317 0,36689634 domain containing 2 2421 100507098 ADAMTS9- ADAMTS9 antisense -0,3519542 2,3610649 0,0454681 0,36689634 AS2 RNA 2 2422 117583 PARD3B par-3 family cell 0,11553947 4,6184279 0,0455072 0,36689634 polarity regulator beta

2423 3155 HMGCL 3-hydroxymethyl-3- -0,1240914 9,0707688 0,0455127 0,36689634 methylglutaryl-CoA lyase 2424 254295 PHYHD1 phytanoyl-CoA -0,1889952 6,7405348 0,0455444 0,36689634 dioxygenase domain containing 1 2425 23052 ENDOD1 endonuclease domain 0,18236235 5,8972114 0,0455872 0,36689634 containing 1 2426 79087 ALG12 ALG12, alpha-1,6- -0,049691 2,6566015 0,0455903 0,36689634 mannosyltransferase

2427 10957 PNRC1 proline-rich nuclear -0,1316883 13,577419 0,0455957 0,36689634 receptor coactivator 1

2428 9807 IP6K1 inositol -0,177138 6,1233101 0,0456013 0,36689634 hexakisphosphate kinase 1 2429 22846 VASH1 vasohibin 1 0,04538485 3,1926136 0,0456097 0,36689634 2430 29952 DPP7 dipeptidyl-peptidase 7 -0,2523632 7,8311685 0,045618 0,36689634

2431 10048 RANBP9 RAN binding protein 9 -0,1212959 9,1502289 0,0456895 0,36702861

2432 2948 GSTM4 glutathione S- -0,2024784 5,9514457 0,0457075 0,36702861 transferase mu 4 2433 84305 WIBG within bgcn homolog -0,1385336 6,3385215 0,0457155 0,36702861 (Drosophila)

2434 10025 MED16 mediator complex -0,0764813 4,0213634 0,0457288 0,36702861 subunit 16 2435 7048 TGFBR2 transforming growth 0,236797 10,914108 0,0457344 0,36702861 factor, beta receptor II (70/80kDa)

2436 23764 MAFF v-maf avian -0,2089612 13,269208 0,0457471 0,36702861 musculoaponeurotic fibrosarcoma oncogene homolog F

2437 8500 PPFIA1 protein tyrosine 0,09541898 6,5784386 0,0457994 0,36717209 phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1

2438 10450 PPIE peptidylprolyl -0,1221246 6,1576269 0,045813 0,36717209 isomerase E (cyclophilin E) 2439 23075 SWAP70 SWAP switching B-cell 0,28044175 9,7022627 0,0458214 0,36717209 complex 70kDa subunit 2440 49855 SCAPER S-phase cyclin A- -0,2320212 5,9163155 0,0458856 0,36753651 associated protein in the ER 2441 5977 DPF2 D4, zinc and double -0,1633933 8,3337374 0,0459114 0,36759175 PHD fingers family 2 2442 118472 ZNF511 zinc finger protein 511 -0,1598821 8,0306474 0,0459414 0,367682 2443 1123 CHN1 chimerin 1 0,35908518 6,7213498 0,0459676 0,36774068 2444 8864 PER2 period circadian clock -0,2140752 8,2247349 0,0461591 0,36912184 2 2445 9092 SART1 squamous cell -0,2501963 6,7161615 0,0462014 0,36930873 carcinoma antigen recognized by T cells

2446 7171 TPM4 tropomyosin 4 0,53788882 7,3004746 0,0462261 0,36935534 2447 9057 SLC7A6 solute carrier family 7 -0,2097969 8,3750261 0,046245 0,36935562 (amino acid transporter light chain, y+L system), member 6 2448 338657 CCDC84 coiled-coil domain -0,1265149 7,299966 0,0463435 0,36999053 containing 84 2449 10254 STAM2 signal transducing 0,08089609 7,3693813 0,0464074 0,37031039 adaptor molecule (SH3 domain and ITAM motif) 2 2450 9541 CIR1 corepressor interacting -0,2555909 8,7142406 0,0464343 0,37031039 with RBPJ, 1

2451 285381 DPH3 diphthamide 0,14652339 9,2799055 0,0464439 0,37031039 biosynthesis 3 2452 4597 MVD mevalonate -0,498975 2,5458929 0,0464639 0,37031039 (diphospho) decarboxylase 2453 54850 FBXL12 F-box and leucine-rich -0,1473651 8,306312 0,0464934 0,37031039 repeat protein 12

2454 117289 TAGAP T-cell activation 0,13961423 2,6551472 0,0464972 0,37031039 RhoGTPase activating protein 2455 64167 ERAP2 endoplasmic reticulum 0,20022496 5,4270779 0,0466047 0,37101497 aminopeptidase 2

2456 28958 COA3 cytochrome c oxidase -0,1241775 10,526258 0,0466334 0,37109277 assembly factor 3

2457 8082 SSPN sarcospan 0,17277858 10,107119 0,0467071 0,37143053 2458 63899 NSUN3 NOP2/Sun domain 0,16961354 4,4633807 0,0467413 0,37143053 family, member 3 2459 3304 HSPA1B heat shock 70kDa -0,2018504 12,518324 0,0467491 0,37143053 protein 1B 2460 51108 METTL9 methyltransferase like -0,0796305 7,65449 0,0467519 0,37143053 9 2461 29883 CNOT7 CCR4-NOT -0,0622577 7,7473882 0,04679 0,37158252 transcription complex, subunit 7 2462 101929604 LOC10192 uncharacterized -0,2560754 2,3730327 0,046869 0,37199824 9604 LOC101929604 2463 56943 ENY2 enhancer of yellow 2 0,0848745 7,6490495 0,0468805 0,37199824 homolog (Drosophila)

2464 9374 PPT2 palmitoyl-protein -0,1116249 2,6511062 0,0469024 0,37202124 thioesterase 2 2465 7290 HIRA histone cell cycle -0,1928778 7,445063 0,0469631 0,37216045 regulator 2466 100137047 JMJD7 jumonji domain -0,1736716 4,4335255 0,0469716 0,37216045 containing 7 2467 83893 SPATA16 spermatogenesis -0,048421 2,2324183 0,0470018 0,37216045 associated 16 2468 79817 MOB3B MOB kinase activator -0,1476759 7,3553384 0,0470449 0,37216045 3B 2469 51374 ATRAID all-trans retinoic acid- -0,11519 12,113774 0,0470696 0,37216045 induced differentiation factor

2470 84246 MED10 mediator complex -0,1136439 7,7196108 0,0470779 0,37216045 subunit 10 2471 133308 SLC9B2 solute carrier family 9, 0,1244711 3,0068152 0,0470834 0,37216045 subfamily B (NHA2, cation proton antiporter 2), member 2 2472 10225 CD96 CD96 molecule -0,1185309 2,2972359 0,0470875 0,37216045 2473 115825 WDFY2 WD repeat and FYVE -0,075936 4,6568957 0,0470913 0,37216045 domain containing 2 2474 64771 C6orf106 chromosome 6 open 0,15296187 7,7550069 0,0471762 0,37268023 reading frame 106

2475 10695 CNPY3 canopy FGF signaling 0,11642903 6,2724841 0,047201 0,37269124 regulator 3 2476 6596 HLTF helicase-like 0,15664541 10,201458 0,0472286 0,37269124 transcription factor 2477 51569 UFM1 ubiquitin-fold modifier 0,22768128 9,6065235 0,0472348 0,37269124 1 2478 55294 FBXW7 F-box and WD repeat 0,16184764 8,4885222 0,047294 0,37300803 domain containing 7, E3 ubiquitin protein ligase

2479 83401 ELOVL3 ELOVL fatty acid -0,657616 4,2045143 0,0475014 0,37449274 elongase 3 2480 1723 DHODH dihydroorotate -0,1603337 3,7298961 0,0475324 0,37455411 dehydrogenase (quinone) 2481 92249 LOC92249 uncharacterized -0,2946656 4,746955 0,04756 0,37455411 LOC92249 2482 51389 RWDD1 RWD domain -0,1421388 11,455576 0,0475787 0,37455411 containing 1 2483 51232 CRIM1 cysteine rich 0,1644113 11,329048 0,0475859 0,37455411 transmembrane BMP regulator 1 (chordin- like) 2484 1059 CENPB centromere protein B, -0,1654469 6,3837544 0,047669 0,37505793 80kDa 2485 6629 SNRPB2 small nuclear -0,1167959 11,435327 0,0477144 0,37520815 ribonucleoprotein polypeptide B 2486 55333 SYNJ2BP synaptojanin 2 binding 0,19846993 8,5010993 0,0477429 0,37520815 protein 2487 8609 KLF7 Kruppel-like factor 7 0,14767776 6,8689521 0,0477457 0,37520815 (ubiquitous) 2488 340371 NRBP2 nuclear receptor -0,1461087 8,4827395 0,0478228 0,37552011 binding protein 2 2489 23301 EHBP1 EH domain binding 0,17536993 11,208741 0,0478289 0,37552011 protein 1 2490 971 CD72 CD72 molecule -0,1246742 2,3047128 0,0478431 0,37552011 2491 54796 BNC2 basonuclin 2 -0,1667962 6,1968675 0,0478745 0,37561595 2492 55754 TMEM30A transmembrane 0,20732212 10,033444 0,0479057 0,37571014 protein 30A 2493 134728 IRAK1BP1 interleukin-1 receptor- -0,4236409 5,1202973 0,0479597 0,37583103 associated kinase 1 binding protein 1

2494 90411 MCFD2 multiple coagulation 0,10774919 10,329698 0,0479744 0,37583103 factor deficiency 2

2495 2215 FCGR3B Fc fragment of IgG, 0,47133497 3,9359692 0,0479788 0,37583103 low affinity IIIb, receptor (CD16b) 2496 23256 SCFD1 sec1 family domain 0,14478662 9,2030679 0,0481101 0,37658448 containing 1 2497 65080 MRPL44 mitochondrial -0,1120341 7,7677677 0,0481136 0,37658448 ribosomal protein L44

2498 222068 TMED4 transmembrane -0,0600943 8,5902707 0,0481427 0,37666205 emp24 protein transport domain containing 4 2499 90333 ZNF468 zinc finger protein 468 0,16541488 7,0782779 0,0482032 0,37698397

2500 26015 RPAP1 RNA polymerase II -0,218342 5,6475273 0,0482261 0,37701212 associated protein 1 2501 9851 KIAA0753 KIAA0753 -0,166097 6,256564 0,0483064 0,37748911 2502 639 PRDM1 PR domain containing 0,39533538 5,2694119 0,048351 0,37768685 1, with ZNF domain 2503 79589 RNF128 ring finger protein 128, -0,2234831 2,438868 0,0484766 0,37842829 E3 ubiquitin protein ligase 2504 26090 ABHD12 abhydrolase domain -0,0667834 7,3198826 0,0484847 0,37842829 containing 12

2505 5440 POLR2K polymerase (RNA) II 0,12359706 10,366945 0,0485626 0,37888484 (DNA directed) polypeptide K, 7.0kDa

2506 3396 ICT1 immature colon -0,1579887 8,6704593 0,0486158 0,37914915 carcinoma transcript 1

2507 51027 BOLA1 bolA family member 1 -0,1260675 6,9937885 0,0486352 0,37914915

2508 2197 FAU Finkel-Biskis-Reilly -0,1792252 13,597221 0,0486654 0,37923291 murine sarcoma virus (FBR-MuSV) ubiquitously expressed

2509 6683 SPAST spastin 0,12023716 5,8670554 0,0486943 0,37930718 2510 3903 LAIR1 leukocyte-associated 0,21713544 8,8842681 0,048742 0,37952766 immunoglobulin-like receptor 1

2511 54922 RASIP1 Ras interacting protein -0,037648 3,2761167 0,048816 0,37987918 1 2512 57648 KIAA1522 KIAA1522 0,19573306 2,7767183 0,0488261 0,37987918 2513 59277 NTN4 netrin 4 0,41474887 8,6412268 0,0488561 0,37996138 2514 134430 WDR36 WD repeat domain 36 0,07019308 6,1105998 0,0489097 0,38016487

2515 2962 GTF2F1 general transcription -0,1048435 6,7019596 0,0489211 0,38016487 factor IIF, polypeptide 1, 74kDa

2516 51552 RAB14 RAB14, member RAS 0,07297744 8,4133839 0,0489654 0,38030139 oncogene family

2517 79089 TMUB2 transmembrane and -0,1273069 8,0082848 0,0489776 0,38030139 ubiquitin-like domain containing 2 2518 55090 MED9 mediator complex -0,149051 2,4234822 0,0490958 0,38106735 subunit 9 2519 25897 RNF19A ring finger protein 19A, 0,16393347 8,6830764 0,0491199 0,38110372 RBR E3 ubiquitin protein ligase 2520 8685 MARCO macrophage receptor 0,26301218 2,5178229 0,0491694 0,38124337 with collagenous structure

2521 57787 MARK4 MAP/microtubule -0,1523512 6,6997047 0,049177 0,38124337 affinity-regulating kinase 4 2522 56950 SMYD2 SET and MYND domain 0,15456915 9,5539436 0,0492132 0,38137329 containing 2 2523 5806 PTX3 pentraxin 3, long -0,6542925 10,783986 0,0492772 0,38171795 2524 284325 C19orf54 chromosome 19 open -0,1741426 6,745758 0,0493005 0,38174663 reading frame 54

2525 80817 CEP44 centrosomal protein 0,04397781 6,4550054 0,0493252 0,38178698 44kDa 2526 116541 MRPL54 mitochondrial -0,1334707 9,2576967 0,0493866 0,38211049 ribosomal protein L54

2527 100507217 LOC10050 uncharacterized -0,1829381 11,893293 0,0494902 0,38268297 7217 LOC100507217 2528 9569 GTF2IRD1 GTF2I repeat domain -0,2389291 7,9905274 0,0494997 0,38268297 containing 1 2529 3689 ITGB2 integrin, beta 2 0,54262046 3,0125761 0,0495848 0,38318935 (complement component 3 receptor 3 and 4 subunit)

2530 80764 THAP7 THAP domain -0,1646813 6,8409223 0,0496079 0,38321607 containing 7 2531 8760 CDS2 CDP-diacylglycerol -0,0857405 7,2632773 0,0497122 0,38379376 synthase (phosphatidate cytidylyltransferase) 2

2532 91289 LMF2 lipase maturation -0,1385046 5,4381442 0,0497364 0,38379376 factor 2 2533 55286 C4orf19 chromosome 4 open -0,296703 7,9182317 0,0497416 0,38379376 reading frame 19

2534 114785 MBD6 methyl-CpG binding -0,1595291 5,596492 0,0498393 0,38430541 domain protein 6 2535 3216 HOXB6 homeobox B6 -0,0957665 5,783681 0,0498563 0,38430541 2536 81490 PTDSS2 phosphatidylserine -0,1276995 5,5605286 0,0498669 0,38430541 synthase 2 2537 23019 CNOT1 CCR4-NOT -0,0782685 5,5657292 0,0499526 0,38481442 transcription complex, subunit 1 2538 57515 SERINC1 serine incorporator 1 0,11970511 14,043554 0,0499979 0,38489074 Supplementary data S2B Adipose tissue - significantly differentially expressed genes in the heavier compared with their leaner co-twins Num Gene ID Gene Gene name logFC Average P-value Adjusted p- ber symbol Expression value

1 761 CA3 carbonic anhydrase III, -2,3927614 9,269184776 1,01E-06 0,0197241 muscle specific 2 10003 NAALAD2 N-acetylated alpha-linked -1,2305685 6,909476546 2,92E-06 0,02852177 acidic dipeptidase 2

3 1152 CKB creatine kinase, brain -0,5653475 10,4441514 7,13E-06 0,04641803 4 29080 CCDC59 coiled-coil domain -0,2565581 9,674194342 1,67E-05 0,0587212 containing 59 5 27286 SRPX2 sushi-repeat containing 0,75495615 8,660665379 1,92E-05 0,0587212 protein, X-linked 2 6 23469 PHF3 PHD finger protein 3 -0,2741872 9,3998008 2,34E-05 0,0587212 7 1632 ECI1 enoyl-CoA delta isomerase -0,5284042 8,74919269 2,57E-05 0,0587212 1 8 219736 STOX1 storkhead box 1 -0,935818 7,162946728 2,63E-05 0,0587212 9 51020 HDDC2 HD domain containing 2 -0,1448796 8,486747213 2,77E-05 0,0587212 10 91624 NEXN nexilin (F actin binding 0,59969611 8,79387635 3,39E-05 0,0587212 protein) 11 7296 TXNRD1 thioredoxin reductase 1 0,50587748 8,924182598 3,47E-05 0,0587212

12 9531 BAG3 BCL2-associated 0,41274935 10,08874922 3,61E-05 0,0587212 athanogene 3 13 64965 MRPS9 mitochondrial ribosomal -0,1949366 8,016970679 4,72E-05 0,06242485 protein S9 14 83892 KCTD10 potassium channel 0,26283783 8,615474381 5,01E-05 0,06242485 tetramerization domain containing 10 15 23012 STK38L serine/threonine kinase 38 0,35850421 8,623453546 5,18E-05 0,06242485 like 16 563 AZGP1 alpha-2-glycoprotein 1, -1,3115195 8,36383394 5,25E-05 0,06242485 zinc-binding 17 51360 MBTPS2 membrane-bound -0,1244447 7,342143612 5,43E-05 0,06242485 transcription factor peptidase, site 2 18 5372 PMM1 phosphomannomutase 1 -0,5571995 7,992351085 8,50E-05 0,07394655

19 8801 SUCLG2 succinate-CoA ligase, GDP- -0,2855704 10,99599204 8,58E-05 0,07394655 forming, beta subunit

20 91689 SMDT1 single-pass membrane -0,1506159 10,50434097 9,29E-05 0,07394655 protein with aspartate-rich tail 1 21 6614 SIGLEC1 sialic acid binding Ig-like 0,65640368 7,482954718 0,0001057 0,07394655 lectin 1, sialoadhesin

22 51562 MBIP MAP3K12 binding -0,2291661 8,340510264 0,0001065 0,07394655 inhibitory protein 1 23 51068 NMD3 NMD3 ribosome export -0,1577188 9,578808725 0,0001098 0,07394655 adaptor 24 6156 RPL30 ribosomal protein L30 -0,1058431 14,89201666 0,0001111 0,07394655 25 92259 MRPS36 mitochondrial ribosomal -0,2429707 9,589582431 0,0001127 0,07394655 protein S36 26 2098 ESD esterase D -0,163376 12,57898749 0,000114 0,07394655 27 10891 PPARGC1 peroxisome proliferator- -0,9078727 4,194267845 0,0001149 0,07394655 A activated receptor gamma, coactivator 1 alpha

28 8777 MPDZ multiple PDZ domain -0,5760449 10,00566789 0,0001159 0,07394655 protein 29 55250 ELP2 elongator -0,2745029 8,380848229 0,0001224 0,07394655 acetyltransferase complex subunit 2 30 84689 MS4A14 membrane-spanning 4- 0,98299967 4,173457474 0,000124 0,07394655 domains, subfamily A, member 14 31 1728 NQO1 NAD(P)H dehydrogenase, 0,90565801 11,37069706 0,0001266 0,07394655 quinone 1

32 60488 MRPS35 mitochondrial ribosomal -0,1366215 8,898478479 0,000129 0,07394655 protein S35 33 55023 PHIP pleckstrin homology -0,2408894 9,110552353 0,0001311 0,07394655 domain interacting protein

34 197257 LDHD lactate dehydrogenase D -0,8457942 5,417009687 0,000132 0,07394655

35 94103 ORMDL3 ORM1-like 3 (S. cerevisiae) -0,6212832 6,463344679 0,0001324 0,07394655

36 1978 EIF4EBP1 eukaryotic translation -0,5635477 7,968456408 0,0001419 0,0740515 initiation factor 4E binding protein 1 37 140733 MACROD MACRO domain containing -0,5942013 6,089199197 0,0001451 0,0740515 2 2 38 3927 LASP1 LIM and SH3 protein 1 0,19289286 11,44839459 0,0001465 0,0740515 39 5337 PLD1 phospholipase D1, -0,2594025 3,836660604 0,0001498 0,0740515 phosphatidylcholine- specific 40 4722 NDUFS3 NADH dehydrogenase -0,1693025 9,60735617 0,0001516 0,0740515 (ubiquinone) Fe-S protein 3, 30kDa (NADH-coenzyme Q reductase) 41 130399 ACVR1C activin A receptor, type IC -0,3716649 11,44771668 0,0001568 0,07410268 42 79611 ACSS3 acyl-CoA synthetase short- -0,6063686 8,916254052 0,0001616 0,07410268 chain family member 3

43 9728 SECISBP2 SECIS binding protein 2- -0,1594376 8,309300828 0,0001729 0,07410268 L like 44 10128 LRPPRC leucine-rich -0,2050189 9,528037204 0,0001736 0,07410268 pentatricopeptide repeat containing 45 7262 PHLDA2 pleckstrin homology-like 1,62263512 5,780414729 0,0001793 0,07410268 domain, family A, member 2 46 115416 MALSU1 mitochondrial assembly of -0,200397 11,23126875 0,0001795 0,07410268 ribosomal large subunit 1

47 56945 MRPS22 mitochondrial ribosomal -0,1984825 9,363014247 0,0001819 0,07410268 protein S22 48 439921 MXRA7 matrix-remodelling 0,38118496 7,146673609 0,0001833 0,07410268 associated 7 49 51187 RSL24D1 ribosomal L24 domain -0,2125207 11,44680648 0,0001905 0,07410268 containing 1 50 56267 CCBL2 cysteine conjugate-beta -0,2410189 10,11001329 0,0001926 0,07410268 lyase 2 51 51646 YPEL5 yippee-like 5 (Drosophila) -0,2580914 11,74410632 0,0001934 0,07410268

52 1154 CISH cytokine inducible SH2- -1,8616338 5,148499645 0,0002117 0,07957806 containing protein 53 2752 GLUL glutamate-ammonia ligase -0,8552949 11,02052409 0,0002191 0,07984487

54 10632 ATP5L ATP synthase, H+ -0,1626433 11,01471765 0,0002206 0,07984487 transporting, mitochondrial Fo complex, subunit G 55 1E+08 SNHG19 small nucleolar RNA host -0,2965219 9,271245775 0,0002303 0,08182708 gene 19 (non-protein coding) 56 23350 U2SURP U2 snRNP-associated SURP -0,168603 9,14013192 0,0002401 0,0837815 domain containing

57 143884 CWF19L2 CWF19-like 2, cell cycle -0,2125554 8,241297819 0,0002474 0,084142 control (S. pombe) 58 9124 PDLIM1 PDZ and LIM domain 1 0,35873396 10,81530505 0,0002529 0,084142 59 5534 PPP3R1 protein phosphatase 3, -0,3792345 8,793120635 0,0002548 0,084142 regulatory subunit B, alpha

60 8204 NRIP1 nuclear receptor -0,4907191 10,61186121 0,0002583 0,084142 interacting protein 1 61 152137 CCDC50 coiled-coil domain -0,2378801 9,325779141 0,0002635 0,08435439 containing 50 62 2960 GTF2E1 general transcription 0,23049753 7,710250282 0,0002818 0,08435439 factor IIE, polypeptide 1, alpha 56kDa 63 10623 POLR3C polymerase (RNA) III (DNA -0,2426465 7,545573759 0,0002823 0,08435439 directed) polypeptide C (62kD) 64 83608 C18orf21 chromosome 18 open -0,3603667 8,300902274 0,0002893 0,08435439 reading frame 21 65 8667 EIF3H eukaryotic translation -0,2082656 11,83607908 0,0002976 0,08435439 initiation factor 3, subunit H 66 3298 HSF2 heat shock transcription -0,2612721 6,783931798 0,0003014 0,08435439 factor 2 67 60487 TRMT11 tRNA methyltransferase 11 -0,2597958 8,404093193 0,0003022 0,08435439 homolog (S. cerevisiae)

68 3693 ITGB5 integrin, beta 5 0,3770682 10,4357702 0,0003042 0,08435439 69 5981 RFC1 replication factor C -0,2262672 8,395833684 0,0003054 0,08435439 (activator 1) 1, 145kDa 70 79665 DHX40 DEAH (Asp-Glu-Ala-His) -0,1566737 9,690093462 0,0003084 0,08435439 box polypeptide 40 71 83939 EIF2A eukaryotic translation -0,2244661 11,15330301 0,0003087 0,08435439 initiation factor 2A, 65kDa

72 1329 COX5B cytochrome c oxidase -0,1611804 11,83128013 0,0003172 0,08435439 subunit Vb 73 113510 HELQ helicase, POLQ-like -0,1969822 6,6548627 0,0003183 0,08435439 74 1327 COX4I1 cytochrome c oxidase -0,1209049 13,09250783 0,0003216 0,08435439 subunit IV isoform 1 75 23285 KIAA110 KIAA1107 -0,4721503 5,869481262 0,0003237 0,08435439 7 76 57088 PLSCR4 phospholipid scramblase 4 -0,3145614 11,65094632 0,0003468 0,08675452

77 10466 COG5 component of oligomeric -0,1966468 7,950809257 0,0003501 0,08675452 golgi complex 5

78 10243 GPHN gephyrin -0,6187529 7,395007752 0,0003511 0,08675452 79 23239 PHLPP1 PH domain and leucine -0,7751879 5,694046058 0,0003517 0,08675452 rich repeat protein phosphatase 1 80 5586 PKN2 protein kinase N2 -0,1812776 10,57619594 0,0003551 0,08675452 81 4528 MTIF2 mitochondrial translational -0,147641 10,19689666 0,0003695 0,08775397 initiation factor 2

82 54815 GATAD2 GATA zinc finger domain 0,1833018 7,874890749 0,0003709 0,08775397 A containing 2A 83 8725 URI1 URI1, prefoldin-like -0,1186473 8,366472007 0,0003762 0,08775397 chaperone 84 2768 GNA12 guanine nucleotide binding 0,24230165 8,354028445 0,0003772 0,08775397 protein (G protein) alpha 12 85 80196 RNF34 ring finger protein 34, E3 0,15400558 8,213320104 0,000386 0,0880206 ubiquitin protein ligase

86 79752 ZFAND1 zinc finger, AN1-type -0,2600722 9,291753834 0,0003913 0,0880206 domain 1 87 6817 SULT1A1 sulfotransferase family, 0,48289686 11,68015235 0,0003935 0,0880206 cytosolic, 1A, phenol- preferring, member 1

88 7291 TWIST1 twist family bHLH -0,5338563 12,04415871 0,0003963 0,0880206 transcription factor 1 89 4724 NDUFS4 NADH dehydrogenase -0,1844476 10,5786819 0,0004102 0,08954811 (ubiquinone) Fe-S protein 4, 18kDa (NADH-coenzyme Q reductase) 90 57470 LRRC47 leucine rich repeat -0,1426323 11,09171168 0,0004188 0,08954811 containing 47 91 10668 CGRRF1 cell growth regulator with -0,2329927 8,146045547 0,0004207 0,08954811 ring finger domain 1

92 26166 RGS22 regulator of G-protein -0,4537373 7,439890928 0,0004301 0,08954811 signaling 22 93 54543 TOMM7 translocase of outer -0,1858142 13,62156517 0,0004334 0,08954811 mitochondrial membrane 7 homolog (yeast)

94 7337 UBE3A ubiquitin protein ligase -0,1367442 8,91142145 0,000445 0,08954811 E3A 95 348 APOE apolipoprotein E -0,7831348 10,24500308 0,0004491 0,08954811 96 7378 UPP1 uridine phosphorylase 1 0,30996181 6,281979254 0,0004503 0,08954811

97 6309 SC5D sterol-C5-desaturase -0,3569957 9,378972575 0,0004618 0,08954811 98 6594 SMARCA SWI/SNF related, matrix -0,236667 9,022815501 0,0004763 0,08954811 1 associated, actin dependent regulator of chromatin, subfamily a, member 1 99 9318 COPS2 COP9 signalosome subunit -0,2523384 10,72079237 0,0004804 0,08954811 2 100 26575 RGS17 regulator of G-protein -0,819127 4,778318471 0,0004852 0,08954811 signaling 17 101 85004 RERG RAS-like, estrogen- 0,49061582 7,358468618 0,000489 0,08954811 regulated, growth inhibitor

102 25871 C3orf17 chromosome 3 open -0,0705642 7,231948802 0,0004903 0,08954811 reading frame 17 103 131873 COL6A6 collagen, type VI, alpha 6 -1,8293734 7,158322189 0,000492 0,08954811

104 58490 RPRD1B regulation of nuclear pre- -0,2242432 7,249093754 0,0004952 0,08954811 mRNA domain containing 1B 105 1615 DARS aspartyl-tRNA synthetase -0,1202743 11,88721106 0,0004965 0,08954811

106 56265 CPXM1 carboxypeptidase X (M14 -1,1488559 6,056596275 0,0004967 0,08954811 family), member 1

107 1605 DAG1 dystroglycan 1 (dystrophin- 0,18110492 6,385153462 0,0005002 0,08954811 associated glycoprotein 1)

108 54675 CRLS1 cardiolipin synthase 1 -0,2535982 9,186616971 0,0005005 0,08954811 109 1191 CLU clusterin 0,45040148 12,21958502 0,0005031 0,08954811 110 140809 SRXN1 sulfiredoxin 1 0,31429713 6,568022615 0,000504 0,08954811 111 27101 CACYBP calcyclin binding protein -0,1843695 9,437864916 0,0005173 0,08986892

112 1528 CYB5A cytochrome b5 type A -0,3359469 13,28059808 0,0005179 0,08986892 (microsomal) 113 80000 GREB1L growth regulation by -0,4825936 3,811302385 0,0005251 0,08986892 estrogen in breast cancer- like 114 10769 PLK2 polo-like kinase 2 0,62824539 9,17524495 0,000534 0,08986892 115 112611 RWDD2A RWD domain containing -0,5267687 3,748932917 0,0005341 0,08986892 2A 116 79017 GGCT gamma- -0,3154463 10,52258831 0,0005352 0,08986892 glutamylcyclotransferase

117 84140 FAM161 family with sequence -0,4424965 3,56660157 0,000538 0,08986892 A similarity 161, member A

118 55728 N4BP2 NEDD4 binding protein 2 -0,2352308 5,855071764 0,0005516 0,09136042

119 23022 PALLD palladin, cytoskeletal 0,60284609 10,56906857 0,0005689 0,09344005 associated protein 120 10634 GAS2L1 growth arrest-specific 2 0,20801943 7,407195597 0,0005777 0,09347014 like 1 121 54749 EPDR1 ependymin related 1 0,53842157 10,44583614 0,000582 0,09347014 122 51185 CRBN cereblon -0,1722184 10,85466261 0,0005835 0,09347014 123 23411 SIRT1 sirtuin 1 -0,4403169 9,798086665 0,0005983 0,0950622 124 3131 HLF hepatic leukemia factor -0,6331403 8,069779648 0,0006093 0,09602587 125 3033 HADH hydroxyacyl-CoA -0,3449579 12,06675726 0,0006242 0,09760243 dehydrogenase 126 10402 ST3GAL6 ST3 beta-galactoside alpha- -0,4620806 6,660950576 0,0006482 0,10054212 2,3-sialyltransferase 6

127 27335 EIF3K eukaryotic translation -0,1357099 12,06391008 0,0006559 0,10082228 initiation factor 3, subunit K 128 219348 PLAC9 placenta-specific 9 0,64468036 11,771491 0,0006663 0,10082228 129 54931 TRMT10C tRNA methyltransferase 10 -0,195155 8,492663612 0,000672 0,10082228 homolog C (S. cerevisiae)

130 4131 MAP1B microtubule-associated 0,58704879 10,0277443 0,0006722 0,10082228 protein 1B 131 10352 WARS2 tryptophanyl tRNA -0,2815087 6,135051229 0,0006758 0,10082228 synthetase 2, mitochondrial 132 900 CCNG1 cyclin G1 -0,2467951 12,31010998 0,0007044 0,10429194 133 203427 SLC25A4 solute carrier family 25, 0,31399414 8,900820241 0,0007212 0,10455829 3 member 43 134 5783 PTPN13 protein tyrosine -0,2897344 8,839524384 0,0007214 0,10455829 phosphatase, non- receptor type 13 (APO- 1/CD95 (Fas)-associated phosphatase)

135 51503 CWC15 CWC15 spliceosome- -0,1842075 10,58731371 0,000723 0,10455829 associated protein homolog (S. cerevisiae) 136 23161 SNX13 sorting nexin 13 -0,176169 7,590949857 0,0007292 0,10455829 137 10240 MRPS31 mitochondrial ribosomal -0,2206826 8,926944097 0,0007329 0,10455829 protein S31 138 55335 NIPSNAP nipsnap homolog 3B (C. -0,7400194 8,756056118 0,0007609 0,1065189 3B elegans) 139 5876 RABGGT Rab -0,1728476 9,655531358 0,0007623 0,1065189 B geranylgeranyltransferase, beta subunit 140 4337 MOCS1 molybdenum cofactor -0,6343177 7,528896116 0,0007671 0,1065189 synthesis 1 141 1652 DDT D-dopachrome -0,2545942 11,59416044 0,000772 0,1065189 tautomerase 142 30844 EHD4 EH-domain containing 4 0,13820874 10,18571912 0,0007739 0,1065189 143 9326 ZNHIT3 zinc finger, HIT-type -0,2591777 9,144302265 0,0007872 0,10759117 containing 3 144 1E+08 SLC25A2 SLC25A21 antisense RNA 1 -0,5153448 5,842153452 0,0008002 0,10860318 1-AS1 145 51386 EIF3L eukaryotic translation -0,1892415 13,72192765 0,0008077 0,10860318 initiation factor 3, subunit L 146 50484 RRM2B ribonucleotide reductase 0,19047698 10,55364376 0,0008113 0,10860318 M2 B (TP53 inducible)

147 255631 COL24A1 collagen, type XXIV, alpha 0,49268744 3,195953541 0,0008214 0,10920953 1 148 55793 FAM63A family with sequence -0,5240697 6,20760823 0,0008414 0,11110552 similarity 63, member A 149 114915 EPB41L4 EPB41L4A antisense RNA 1 -0,447451 10,19707494 0,0008588 0,11232767 A-AS1 150 51000 SLC35B3 solute carrier family 35 0,15828365 10,22902682 0,0008632 0,11232767 (adenosine 3'-phospho 5'- phosphosulfate transporter), member B3

151 114112 TXNRD3 thioredoxin reductase 3 -0,2813336 5,744520005 0,0008679 0,11232767

152 7011 TEP1 telomerase-associated 0,18962704 3,708607269 0,0008769 0,1127458 protein 1 153 10655 DMRT2 doublesex and mab-3 -0,5054457 9,026238801 0,0008931 0,11304215 related transcription factor 2 154 79772 MCTP1 multiple C2 domains, 0,3954706 7,31433203 0,0008957 0,11304215 transmembrane 1 155 153396 TMEM16 transmembrane protein -0,1068289 7,166595772 0,000901 0,11304215 1B 161B 156 388335 TMEM22 transmembrane protein -0,3495466 8,138621613 0,0009023 0,11304215 0 220 157 23175 LPIN1 lipin 1 -0,6752323 9,633207715 0,0009157 0,11343353 158 5264 PHYH phytanoyl-CoA 2- -0,2323977 12,03387666 0,000917 0,11343353 hydroxylase 159 22 ABCB7 ATP-binding cassette, sub- -0,2429411 9,183990416 0,0009426 0,11586004 family B (MDR/TAP), member 7 160 4281 MID1 midline 1 (Opitz/BBB 0,41884761 8,539341842 0,0009648 0,11729473 syndrome) 161 1E+08 LOC1005 endogenous Bornavirus- -0,1479868 9,984474064 0,0009663 0,11729473 06710 like nucleoprotein 2 pseudogene 162 6574 SLC20A1 solute carrier family 20 0,31218445 8,293741752 0,0009793 0,11751309 (phosphate transporter), member 1 163 3667 IRS1 insulin receptor substrate -0,4248725 8,399549575 0,0009804 0,11751309 1 164 5862 RAB2A RAB2A, member RAS 0,13358955 9,989733035 0,0009912 0,11751309 oncogene family 165 131544 CRYBG3 beta-gamma crystallin -0,2557789 10,32695053 0,0009969 0,11751309 domain containing 3 166 2495 FTH1 ferritin, heavy polypeptide 0,4251699 11,94299569 0,0009981 0,11751309 1 167 10042 HMGXB4 HMG box domain -0,1921035 8,104392352 0,0010432 0,12063064 containing 4 168 129787 TMEM18 transmembrane protein 18 -0,2280824 7,777981418 0,0010624 0,12063064

169 3913 LAMB2 laminin, beta 2 (laminin S) 0,23969694 9,425386725 0,0010706 0,12063064

170 4594 MUT methylmalonyl CoA -0,2362663 10,26335852 0,0010714 0,12063064 mutase 171 8660 IRS2 insulin receptor substrate -0,5107172 12,30165027 0,0010752 0,12063064 2 172 5209 PFKFB3 6-phosphofructo-2- -0,4419397 14,01631172 0,001076 0,12063064 kinase/fructose-2,6- biphosphatase 3 173 757 TMEM50 transmembrane protein -0,1775322 9,140611991 0,0010823 0,12063064 B 50B 174 10203 CALCRL calcitonin receptor-like -0,502838 7,441186047 0,0010886 0,12063064 175 80760 ITIH5 inter-alpha-trypsin 0,46437603 12,57554068 0,0010906 0,12063064 inhibitor heavy chain family, member 5 176 127281 FAM213 family with sequence 0,32200457 6,734195431 0,0010973 0,12063064 B similarity 213, member B

177 55284 UBE2W ubiquitin-conjugating -0,1560465 6,867041349 0,0011087 0,12063064 enzyme E2W (putative) 178 3396 ICT1 immature colon carcinoma -0,1745637 8,91591136 0,001109 0,12063064 transcript 1 179 54816 ZNF280D zinc finger protein 280D -0,2499773 8,917208673 0,0011122 0,12063064

180 1E+08 PRKAG2- PRKAG2 antisense RNA 1 -0,3823465 7,457036528 0,0011164 0,12063064 AS1 181 122622 ADSSL1 adenylosuccinate synthase -0,7966766 8,378011022 0,0011255 0,12063064 like 1 182 401115 C4orf48 chromosome 4 open 0,46158953 7,382693664 0,001126 0,12063064 reading frame 48 183 5827 PXMP2 peroxisomal membrane -0,5519628 8,342976837 0,0011297 0,12063064 protein 2, 22kDa

184 6208 RPS14 ribosomal protein S14 -0,2035261 13,98841123 0,0011385 0,12063064 185 60481 ELOVL5 ELOVL fatty acid elongase -0,3491653 13,35492936 0,0011486 0,12063064 5 186 9324 HMGN3 high mobility group -0,1333217 12,43001538 0,001149 0,12063064 nucleosomal binding domain 3 187 122953 JDP2 Jun dimerization protein 2 0,1680679 6,136632589 0,0011557 0,12063064

188 11215 AKAP11 A kinase (PRKA) anchor -0,150466 10,90129376 0,0011604 0,12063064 protein 11 189 55897 MESP1 mesoderm posterior 1 -0,456054 8,541324084 0,0011684 0,12080839 homolog (mouse) 190 201161 CENPV centromere protein V -0,5478669 6,673225453 0,0011764 0,12080839 191 9541 CIR1 corepressor interacting -0,2043427 8,927236056 0,0011806 0,12080839 with RBPJ, 1 192 51164 DCTN4 dynactin 4 (p62) -0,2649431 8,969009018 0,0012154 0,12206433 193 79739 TTLL7 tubulin tyrosine ligase-like -0,7299548 6,464366953 0,001226 0,12206433 family, member 7 194 126259 TMIGD2 transmembrane and -0,2446801 3,562482395 0,0012266 0,12206433 immunoglobulin domain containing 2 195 9330 GTF3C3 general transcription -0,2054225 7,213828322 0,0012272 0,12206433 factor IIIC, polypeptide 3, 102kDa 196 25940 FAM98A family with sequence 0,24635837 10,50965444 0,0012292 0,12206433 similarity 98, member A

197 6135 RPL11 ribosomal protein L11 -0,1271025 14,37534849 0,001236 0,12206433 198 9702 CEP57 centrosomal protein -0,2075902 8,356902254 0,0012509 0,12206433 57kDa 199 1938 EEF2 eukaryotic translation -0,1165123 13,98856189 0,0012514 0,12206433 elongation factor 2 200 293 SLC25A6 solute carrier family 25 -0,1718721 12,39246048 0,0012597 0,12206433 (mitochondrial carrier; adenine nucleotide translocator), member 6

201 84186 ZCCHC7 zinc finger, CCHC domain -0,1294553 7,515127281 0,0012621 0,12206433 containing 7 202 1E+08 LOC1001 uncharacterized 0,48379676 7,832024348 0,0012706 0,12206433 32891 LOC100132891 203 358 AQP1 aquaporin 1 (Colton blood 0,36674199 10,68000812 0,0012725 0,12206433 group) 204 10939 AFG3L2 AFG3-like AAA ATPase 2 -0,1978062 9,198614286 0,0012741 0,12206433

205 51524 TMEM13 transmembrane protein 0,33298567 9,226860774 0,001304 0,12422549 8 138 206 283 ANG angiogenin, ribonuclease, -0,4281 8,956801344 0,0013152 0,12422549 RNase A family, 5

207 23011 RAB21 RAB21, member RAS -0,1319522 9,809345146 0,0013194 0,12422549 oncogene family 208 6840 SVIL supervillin -0,4444813 8,952429959 0,0013281 0,12422549 209 9781 RNF144A ring finger protein 144A -0,4854724 8,803860035 0,0013318 0,12422549

210 7803 PTP4A1 protein tyrosine -0,2968949 8,752794288 0,0013388 0,12422549 phosphatase type IVA, member 1 211 84311 MRPL45 mitochondrial ribosomal -0,1611804 8,079540583 0,00136 0,12422549 protein L45 212 4711 NDUFB5 NADH dehydrogenase -0,2338919 12,40355822 0,0013626 0,12422549 (ubiquinone) 1 beta subcomplex, 5, 16kDa 213 4147 MATN2 matrilin 2 -0,293572 11,20381194 0,0013683 0,12422549 214 10019 SH2B3 SH2B adaptor protein 3 0,38381552 8,946129502 0,0013858 0,12422549 215 162073 ITPRIPL2 inositol 1,4,5- 0,17926276 9,548949139 0,0013911 0,12422549 trisphosphate receptor interacting protein-like 2

216 55288 RHOT1 ras homolog family -0,1897934 10,67551949 0,0013926 0,12422549 member T1 217 79269 DCAF10 DDB1 and CUL4 associated -0,1302884 7,500042275 0,0013941 0,12422549 factor 10 218 26353 HSPB8 heat shock 22kDa protein 0,53949179 9,925354664 0,0013978 0,12422549 8 219 6876 TAGLN transgelin 0,62806576 10,02267228 0,0014172 0,12422549 220 10480 EIF3M eukaryotic translation -0,190894 11,73170949 0,0014251 0,12422549 initiation factor 3, subunit M 221 7132 TNFRSF1 tumor necrosis factor 0,20665415 9,82138843 0,0014353 0,12422549 A receptor superfamily, member 1A 222 55758 RCOR3 REST corepressor 3 -0,2667182 8,997421912 0,0014381 0,12422549 223 7345 UCHL1 ubiquitin carboxyl-terminal 1,47788579 8,92064984 0,0014406 0,12422549 esterase L1 (ubiquitin thiolesterase)

224 54510 PCDH18 protocadherin 18 -0,3070311 9,354220063 0,001449 0,12422549 225 3162 HMOX1 heme oxygenase 0,67521873 7,445924034 0,0014508 0,12422549 (decycling) 1 226 3087 HHEX hematopoietically 0,58739856 6,156544711 0,0014517 0,12422549 expressed homeobox 227 6091 ROBO1 roundabout, axon -0,2915021 10,71118701 0,0014518 0,12422549 guidance receptor, homolog 1 (Drosophila) 228 26157 GIMAP2 GTPase, IMAP family 0,24390594 8,950426026 0,0014535 0,12422549 member 2 229 51099 ABHD5 abhydrolase domain -0,5164973 9,114241591 0,0014556 0,12422549 containing 5 230 1102 RCBTB2 regulator of chromosome 0,12584378 9,853862237 0,0014925 0,12682034 condensation (RCC1) and BTB (POZ) domain containing protein 2

231 286336 FAM78A family with sequence 0,25374031 6,933595656 0,0015005 0,12695151 similarity 78, member A

232 8682 PEA15 phosphoprotein enriched 0,30435383 9,939215064 0,0015175 0,12764228 in astrocytes 15

233 64102 TNMD tenomodulin 1,13250607 11,42714031 0,0015267 0,12764228 234 51389 RWDD1 RWD domain containing 1 -0,1236176 11,9031142 0,0015283 0,12764228

235 3290 HSD11B1 hydroxysteroid (11-beta) 0,88048892 9,254285656 0,0015372 0,12784444 dehydrogenase 1 236 25975 EGFL6 EGF-like-domain, multiple 2,59586599 8,14791359 0,0015518 0,12851384 6 237 4733 DRG1 developmentally regulated -0,2035875 10,35254625 0,0015781 0,1296197 GTP binding protein 1 238 1E+08 HEIH hepatocellular carcinoma -0,1700656 9,485152401 0,0015865 0,1296197 up-regulated EZH2- associated long non- coding RNA

239 3646 EIF3E eukaryotic translation -0,1632407 13,7250878 0,0015873 0,1296197 initiation factor 3, subunit E 240 2743 GLRB glycine receptor, beta -0,3786742 6,141612177 0,001597 0,1296197 241 203522 DDX26B DEAD/H (Asp-Glu-Ala- 0,19596056 5,004953845 0,0015984 0,1296197 Asp/His) box polypeptide 26B 242 11104 KATNA1 katanin p60 (ATPase -0,1878299 7,879650754 0,0016188 0,13046557 containing) subunit A 1 243 8895 CPNE3 copine III -0,1645434 9,616089511 0,0016227 0,13046557 244 219972 MPEG1 macrophage expressed 1 0,39750627 9,546943947 0,0016296 0,13046557

245 55031 USP47 ubiquitin specific -0,1067912 8,220224715 0,0016407 0,13046557 peptidase 47 246 2218 FKTN fukutin 0,28517197 6,365544257 0,0016422 0,13046557 247 29915 HCFC2 host cell factor C2 -0,1099924 7,788142911 0,0016509 0,13054412 248 84749 USP30 ubiquitin specific -0,422843 8,069580223 0,0016616 0,13054412 peptidase 30 249 56271 BEX4 brain expressed, X-linked 4 -0,260966 8,845063634 0,0016632 0,13054412

250 90 ACVR1 activin A receptor, type I -0,2604571 10,0478535 0,0016794 0,13129042

251 57037 ANKMY2 ankyrin repeat and MYND -0,2558167 9,710548184 0,0016918 0,13173015 domain containing 2

252 125 ADH1B alcohol dehydrogenase 1B -0,3614249 14,61108397 0,0017 0,1318435 (class I), beta polypeptide

253 25807 RHBDD3 rhomboid domain 0,28606696 6,013159588 0,0017146 0,13245186 containing 3 254 1E+08 MAGOH2 mago-nashi homolog 2 -0,3884538 3,638403081 0,0017337 0,13301654 (pseudogene) 255 2817 GPC1 glypican 1 0,37311706 5,022820709 0,0017355 0,13301654 256 64969 MRPS5 mitochondrial ribosomal -0,1131708 7,859536477 0,001746 0,13329458 protein S5 257 56920 SEMA3G sema domain, 0,41633449 11,8973749 0,0017554 0,13349528 immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3G

258 10575 CCT4 chaperonin containing -0,1395399 11,11361093 0,0017799 0,13423203 TCP1, subunit 4 (delta) 259 55812 SPATA7 spermatogenesis -0,3219136 7,43255557 0,0017885 0,13423203 associated 7 260 79155 TNIP2 TNFAIP3 interacting 0,20257138 7,564819304 0,0017904 0,13423203 protein 2 261 23517 SKIV2L2 superkiller viralicidic -0,1383727 9,438243798 0,0017978 0,13423203 activity 2-like 2 (S. cerevisiae) 262 6185 RPN2 ribophorin II 0,23905081 11,70540651 0,0018004 0,13423203 263 254863 TMEM25 transmembrane protein -0,2472752 9,640195669 0,0018063 0,13423203 6 256 264 26520 TIMM9 translocase of inner -0,2016811 9,388711547 0,0018196 0,13470665 mitochondrial membrane 9 homolog (yeast)

265 10988 METAP2 methionyl aminopeptidase -0,1090517 9,664499574 0,0018335 0,1347545 2 266 58475 MS4A7 membrane-spanning 4- 0,52610922 8,309431319 0,0018381 0,1347545 domains, subfamily A, member 7 267 91107 TRIM47 tripartite motif containing 0,47964113 5,830657484 0,0018462 0,1347545 47 268 55884 WSB2 WD repeat and SOCS box 0,13730355 10,92418735 0,0018478 0,1347545 containing 2 269 138151 NACC2 NACC family member 2, 0,12925406 8,971416228 0,001891 0,13557749 BEN and BTB (POZ) domain containing 270 8407 TAGLN2 transgelin 2 0,46857485 8,489503117 0,0018934 0,13557749 271 7342 UBP1 upstream binding protein 0,249277 9,858772085 0,0018984 0,13557749 1 (LBP-1a) 272 119559 SFXN4 sideroflexin 4 -0,227482 7,564752145 0,0018986 0,13557749 273 51309 ARMCX1 armadillo repeat -0,1440811 10,79875393 0,0018989 0,13557749 containing, X-linked 1 274 25913 POT1 protection of telomeres 1 -0,1452325 7,250663068 0,0019007 0,13557749

275 4363 ABCC1 ATP-binding cassette, sub- 0,29758936 7,15562177 0,0019126 0,13592655 family C (CFTR/MRP), member 1 276 10884 MRPS30 mitochondrial ribosomal -0,1841797 7,28476247 0,0019315 0,13641762 protein S30 277 1436 CSF1R colony stimulating factor 1 0,45256444 6,978574917 0,0019379 0,13641762 receptor 278 255919 CNEP1R1 CTD nuclear envelope 0,15792722 9,090419352 0,0019404 0,13641762 phosphatase 1 regulatory subunit 1 279 3621 ING1 inhibitor of growth family, -0,2538713 5,3608318 0,0019513 0,13668944 member 1 280 29953 TRHDE thyrotropin-releasing -0,3365371 8,30874922 0,0019583 0,13668989 hormone degrading enzyme 281 401233 HTATSF1 HIV-1 Tat specific factor 1 0,39471744 6,587002673 0,0019842 0,13772701 P2 pseudogene 2 282 1031 CDKN2C cyclin-dependent kinase -0,4987451 12,21944565 0,001992 0,13772701 inhibitor 2C (p18, inhibits CDK4) 283 23171 GPD1L glycerol-3-phosphate -0,5554294 10,35200658 0,0019972 0,13772701 dehydrogenase 1-like 284 9863 MAGI2 membrane associated -0,2917113 6,697545902 0,0020063 0,13772701 guanylate kinase, WW and PDZ domain containing 2

285 115123 MARCH3 membrane-associated ring -0,3191808 6,059489924 0,0020152 0,13772701 finger (C3HC4) 3, E3 ubiquitin protein ligase

286 5091 PC pyruvate carboxylase -0,4557649 9,107480938 0,0020228 0,13772701 287 79829 NAA40 N(alpha)-acetyltransferase 0,23489483 3,86054167 0,0020273 0,13772701 40, NatD catalytic subunit

288 22863 ATG14 autophagy related 14 -0,1845932 9,043477705 0,0020328 0,13772701 289 80007 C10orf88 chromosome 10 open -0,1854802 5,104563524 0,0020366 0,13772701 reading frame 88 290 26589 MRPL46 mitochondrial ribosomal -0,2360912 8,448053609 0,0020863 0,14060353 protein L46 291 3030 HADHA hydroxyacyl-CoA -0,207524 10,37046781 0,0021007 0,1410843 dehydrogenase/3-ketoacyl- CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit

292 25875 LETMD1 LETM1 domain containing -0,305682 10,07002347 0,0021217 0,14201006 1 293 221061 FAM171 family with sequence 0,31943711 9,039756448 0,0021459 0,14314079 A1 similarity 171, member A1

294 51116 MRPS2 mitochondrial ribosomal -0,3520498 7,634605474 0,0021739 0,14451165 protein S2 295 51592 TRIM33 tripartite motif containing -0,1445691 8,683461513 0,0021891 0,14502955 33 296 54414 SIAE sialic acid acetylesterase 0,18111438 6,563495133 0,0022031 0,1454647

297 84661 DPY30 dpy-30 homolog (C. -0,1404817 10,32366597 0,0022379 0,14646068 elegans) 298 10990 LILRB5 leukocyte immunoglobulin- 0,58123414 7,614909858 0,0022433 0,14646068 like receptor, subfamily B (with TM and ITIM domains), member 5

299 388789 LINC0049 long intergenic non- -0,1296158 10,80218564 0,0022517 0,14646068 3 protein coding RNA 493 300 80321 CEP70 centrosomal protein -0,2111153 5,554989035 0,0022653 0,14646068 70kDa 301 6902 TBCA tubulin folding cofactor A -0,1449131 13,55991385 0,0022663 0,14646068

302 90507 SCRN2 secernin 2 -0,2791556 7,931755087 0,0022673 0,14646068 303 662 BNIP1 BCL2/adenovirus E1B -0,2128851 5,782986576 0,0022715 0,14646068 19kDa interacting protein 1 304 283635 FAM177 family with sequence 0,26062129 9,608306267 0,0022806 0,14646068 A1 similarity 177, member A1

305 55111 PLEKHJ1 pleckstrin homology -0,3491693 7,581178399 0,0022918 0,14646068 domain containing, family J member 1 306 521 ATP5I ATP synthase, H+ -0,1343398 12,28579227 0,0022977 0,14646068 transporting, mitochondrial Fo complex, subunit E 307 8727 CTNNAL1 catenin (cadherin- -0,3543845 10,45774181 0,0023006 0,14646068 associated protein), alpha- like 1 308 84134 TOMM40 translocase of outer 0,33652225 7,65558446 0,0023309 0,14790353 L mitochondrial membrane 40 homolog (yeast)-like

309 2108 ETFA electron-transfer- -0,3365512 12,22128071 0,0023562 0,14811636 flavoprotein, alpha polypeptide 310 23414 ZFPM2 zinc finger protein, FOG -0,2880573 9,38444738 0,0023567 0,14811636 family member 2 311 1410 CRYAB crystallin, alpha B 0,44396211 13,88553517 0,0023569 0,14811636 312 3759 KCNJ2 potassium inwardly- 0,66891914 5,09285777 0,0023936 0,1492706 rectifying channel, subfamily J, member 2 313 26020 LRP10 low density lipoprotein 0,16042704 7,1628222 0,0023954 0,1492706 receptor-related protein 10 314 55168 MRPS18 mitochondrial ribosomal -0,166567 7,488608889 0,002404 0,1492706 A protein S18A 315 10656 KHDRBS3 KH domain containing, -0,3268362 6,796763915 0,0024059 0,1492706 RNA binding, signal transduction associated 3

316 221687 RNF182 ring finger protein 182 0,72718553 4,777836394 0,0024476 0,151233 317 6256 RXRA retinoid X receptor, alpha -0,4358479 7,293770894 0,0024616 0,151233

318 79036 KXD1 KxDL motif containing 1 0,13530178 7,883397053 0,0024653 0,151233 319 4357 MPST mercaptopyruvate -0,2421078 8,271766005 0,0024684 0,151233 sulfurtransferase 320 31 ACACA acetyl-CoA carboxylase -0,5494534 9,547711548 0,0024878 0,15194524 alpha 321 64343 AZI2 5-azacytidine induced 2 -0,1894388 8,187113005 0,0024958 0,15195818 322 84324 SARNP SAP domain containing -0,1194781 7,715823759 0,0025162 0,15271983 ribonucleoprotein 323 28232 SLCO3A1 solute carrier organic 0,21810385 6,065219357 0,0025358 0,1530356 anion transporter family, member 3A1 324 23176 SEPT8 septin 8 0,30165315 7,503381775 0,0025591 0,1530356 325 55228 PNMAL1 paraneoplastic Ma antigen 0,61542445 5,58939414 0,0025674 0,1530356 family-like 1 326 4212 MEIS2 Meis homeobox 2 -0,2096733 8,697488329 0,002568 0,1530356 327 10427 SEC24B SEC24 family member B -0,198279 10,62202621 0,0025726 0,1530356 328 28973 MRPS18B mitochondrial ribosomal -0,1540448 8,965238661 0,0025767 0,1530356 protein S18B 329 389136 VGLL3 vestigial-like family 0,51648857 9,978074752 0,0025859 0,1530356 member 3 330 51650 MRPS33 mitochondrial ribosomal -0,226049 9,515280726 0,002593 0,1530356 protein S33 331 57538 ALPK3 alpha-kinase 3 -0,9834946 4,637696472 0,0025964 0,1530356 332 114789 SLC25A2 solute carrier family 25 -0,5815578 6,25986189 0,0025997 0,1530356 5 (mitochondrial carrier; phosphate carrier), member 25 333 65986 ZBTB10 zinc finger and BTB domain -0,1611041 6,572509602 0,0026198 0,15350941 containing 10 334 79789 CLMN calmin (calponin-like, -0,3763258 7,549536826 0,0026234 0,15350941 transmembrane) 335 10950 BTG3 BTG family, member 3 -0,351004 9,638125837 0,0026334 0,15363424 336 84792 FAM220 family with sequence 0,13071213 10,05963603 0,0026416 0,15365483 A similarity 220, member A

337 79145 CHCHD7 coiled-coil-helix-coiled-coil- -0,1673357 8,23194477 0,0026571 0,15409789 helix domain containing 7

338 10560 SLC19A2 solute carrier family 19 -0,5975128 9,284979068 0,0026797 0,15431938 (thiamine transporter), member 2 339 1E+08 RP11- uncharacterized 0,32407801 5,36589863 0,0026809 0,15431938 15A1.3 LOC100505715 340 9349 RPL23 ribosomal protein L23 -0,08265 15,04005749 0,0026882 0,15431938 341 23258 DENND5 DENN/MADD domain 0,2088608 10,40289672 0,0026925 0,15431938 A containing 5A 342 54875 CNTLN centlein, centrosomal -0,2047725 3,726643476 0,00271 0,15486528 protein 343 5885 RAD21 RAD21 homolog (S. -0,1978349 9,426668136 0,0027404 0,15502995 pombe) 344 25901 CCDC28A coiled-coil domain -0,2110713 9,880505613 0,0027552 0,15502995 containing 28A 345 143458 LDLRAD3 low density lipoprotein -0,3301549 9,611176397 0,0027584 0,15502995 receptor class A domain containing 3 346 8655 DYNLL1 dynein, light chain, LC8- 0,18304316 14,26297325 0,0027678 0,15502995 type 1 347 130916 MTERFD MTERF domain containing -0,1191322 6,19650202 0,0027743 0,15502995 2 2 348 65985 AACS acetoacetyl-CoA -0,7226653 9,446799975 0,0027796 0,15502995 synthetase 349 3937 LCP2 lymphocyte cytosolic 0,44579714 6,972212483 0,0027843 0,15502995 protein 2 (SH2 domain containing leukocyte protein of 76kDa) 350 26084 ARHGEF2 Rho guanine nucleotide -0,7334685 5,898741632 0,0027853 0,15502995 6 exchange factor (GEF) 26

351 55876 GSDMB gasdermin B -0,9420939 6,585881681 0,0027934 0,15502995 352 308 ANXA5 annexin A5 0,21541733 13,83582555 0,0027946 0,15502995 353 54464 XRN1 5'-3' exoribonuclease 1 -0,1120843 8,694829177 0,0028001 0,15502995 354 9208 LRRFIP1 leucine rich repeat (in FLII) 0,27249338 10,1719279 0,0028093 0,15509929 interacting protein 1

355 5163 PDK1 pyruvate dehydrogenase -0,3043642 4,304061759 0,0028373 0,15620123 kinase, isozyme 1

356 7018 TF transferrin -0,6712526 12,188741 0,0028465 0,15627104 357 23376 UFL1 UFM1-specific ligase 1 -0,1750532 9,699785357 0,0028723 0,15700192 358 54529 ASNSD1 asparagine synthetase -0,1223667 10,52889457 0,0028779 0,15700192 domain containing 1 359 2644 GCHFR GTP cyclohydrolase I -0,6034379 8,043356807 0,0029073 0,15700192 feedback regulator 360 26060 APPL1 adaptor protein, -0,14665 8,603317552 0,0029089 0,15700192 phosphotyrosine interaction, PH domain and leucine zipper containing 1 361 51277 DNAJC27 DnaJ (Hsp40) homolog, -0,188594 4,534371521 0,0029153 0,15700192 subfamily C, member 27

362 54941 RNF125 ring finger protein 125, E3 -0,4671873 8,0701734 0,0029165 0,15700192 ubiquitin protein ligase

363 5108 PCM1 pericentriolar material 1 -0,172562 8,977424302 0,002921 0,15700192

364 23303 KIF13B kinesin family member 0,22859409 6,555035043 0,0029247 0,15700192 13B 365 54463 FAM134 family with sequence -0,4841436 8,36834655 0,0029321 0,15700192 B similarity 134, member B

366 5096 PCCB propionyl CoA carboxylase, -0,4132906 8,763166493 0,0029451 0,1570969 beta polypeptide

367 23235 SIK2 salt-inducible kinase 2 -0,3763021 9,207255375 0,00295 0,1570969 368 5641 LGMN legumain 0,37969595 10,77398534 0,0029615 0,15710774 369 2631 GBAS glioblastoma amplified -0,2301331 12,17062896 0,0029774 0,15710774 sequence 370 53371 NUP54 nucleoporin 54kDa -0,1211123 10,74399453 0,002979 0,15710774 371 7327 UBE2G2 ubiquitin-conjugating 0,18632917 9,83400165 0,0029823 0,15710774 enzyme E2G 2 372 10157 AASS aminoadipate- -0,6027069 7,40890384 0,0030181 0,15778821 semialdehyde synthase 373 57606 SLAIN2 SLAIN motif family, 0,12683395 6,619064914 0,0030225 0,15778821 member 2 374 54800 KLHL24 kelch-like family member -0,3379617 7,67259904 0,0030274 0,15778821 24 375 2195 FAT1 FAT atypical cadherin 1 0,27773734 11,56222397 0,0030356 0,15778821 376 5998 RGS3 regulator of G-protein -0,6836921 5,812503545 0,0030356 0,15778821 signaling 3 377 84517 ACTRT3 actin-related protein T3 -0,1638481 3,458534075 0,0030566 0,1584566 378 23604 DAPK2 death-associated protein -0,6863381 7,353279552 0,0030874 0,15962808 kinase 2 379 1534 CYB561 cytochrome b561 0,31300024 6,836371211 0,0031088 0,16031122 380 3735 KARS lysyl-tRNA synthetase -0,14077 11,30495928 0,0031264 0,16060506 381 51110 LACTB2 lactamase, beta 2 -0,3102433 9,093845337 0,0031309 0,16060506 382 1350 COX7C cytochrome c oxidase -0,3200906 9,689307031 0,0031647 0,16158873 subunit VIIc 383 9926 LPGAT1 lysophosphatidylglycerol 0,29806504 9,652263159 0,0031678 0,16158873 acyltransferase 1 384 23392 KIAA036 KIAA0368 -0,158527 10,37432858 0,0031749 0,16158873 8 385 1345 COX6C cytochrome c oxidase -0,1361352 13,19526273 0,003196 0,16189131 subunit VIc 386 51493 RTCB RNA 2',3'-cyclic phosphate -0,1458037 9,547857918 0,0031974 0,16189131 and 5'-OH ligase

387 64764 CREB3L2 cAMP responsive element 0,13689161 8,885173115 0,0032449 0,16386952 binding protein 3-like 2

388 55857 KIZ kizuna centrosomal -0,2556205 8,736974558 0,0032946 0,16540067 protein 389 687 KLF9 Kruppel-like factor 9 -0,2403448 9,268466769 0,0033029 0,16540067 390 137075 CLDN23 claudin 23 -0,4210145 5,441346157 0,0033052 0,16540067 391 57563 KLHL8 kelch-like family member 8 -0,1756871 9,204065454 0,0033252 0,16540067

392 80704 SLC19A3 solute carrier family 19 -0,6037798 10,15108979 0,0033418 0,16540067 (thiamine transporter), member 3 393 25943 C20orf19 chromosome 20 open 0,22848529 8,389410532 0,0033442 0,16540067 4 reading frame 194 394 9530 BAG4 BCL2-associated -0,3429747 7,158470223 0,0033443 0,16540067 athanogene 4 395 64065 PERP PERP, TP53 apoptosis 0,31795686 9,121465483 0,0033462 0,16540067 effector 396 7280 TUBB2A tubulin, beta 2A class IIa 0,53580137 13,20698427 0,0033513 0,16540067

397 10318 TNIP1 TNFAIP3 interacting 0,3218159 11,54438594 0,0033624 0,16546426 protein 1 398 57136 APMAP adipocyte plasma -0,2348138 11,78426311 0,0033696 0,16546426 membrane associated protein 399 57148 RALGAPB Ral GTPase activating 0,0888684 6,003464137 0,0034028 0,16667823 protein, beta subunit (non- catalytic) 400 7905 REEP5 receptor accessory protein 0,13520978 11,70680228 0,0034131 0,16676468 5 401 1477 CSTF1 cleavage stimulation -0,0893234 6,37056752 0,0034256 0,1669558 factor, 3' pre-RNA, subunit 1, 50kDa 402 901 CCNG2 cyclin G2 -0,376886 9,543071795 0,0034366 0,16707649 403 9045 RPL14 ribosomal protein L14 -0,1596565 14,00506469 0,0034588 0,16732594 404 6936 GCFC2 GC-rich sequence DNA- -0,2334639 6,905879002 0,0034588 0,16732594 binding factor 2 405 463 ZFHX3 zinc finger homeobox 3 0,15123095 5,422860242 0,0034811 0,16788001 406 6284 S100A13 S100 calcium binding -0,1786393 11,57089372 0,0034875 0,16788001 protein A13 407 124 ADH1A alcohol dehydrogenase 1A -0,5161789 4,675367401 0,0035062 0,16815029 (class I), alpha polypeptide

408 80097 MZT2B mitotic spindle organizing -0,1617145 9,160153276 0,0035103 0,16815029 protein 2B 409 3265 HRAS Harvey rat sarcoma viral 0,31607942 8,156683138 0,0035355 0,16894263 oncogene homolog

410 5464 PPA1 pyrophosphatase 0,18126046 13,94912367 0,0035651 0,169606 (inorganic) 1 411 1E+08 HOXD- HOXD cluster antisense -0,2888718 4,389919252 0,0035667 0,169606 AS2 RNA 2 412 2551 GABPA GA binding protein -0,1901028 7,240437298 0,0035771 0,16966414 transcription factor, alpha subunit 60kDa 413 1347 COX7A2 cytochrome c oxidase -0,148285 13,21484955 0,0035853 0,16966414 subunit VIIa polypeptide 2 (liver) 414 23169 SLC35D1 solute carrier family 35 0,15102003 5,189598038 0,0036057 0,16967567 (UDP-GlcA/UDP-GalNAc transporter), member D1

415 10694 CCT8 chaperonin containing -0,0964212 12,87786689 0,0036072 0,16967567 TCP1, subunit 8 (theta) 416 729 C6 complement component 6 -1,0399857 7,901003805 0,0036116 0,16967567

417 10186 LHFP lipoma HMGIC fusion -0,1591579 12,11718591 0,0036258 0,16982474 partner 418 23603 CORO1C coronin, actin binding 0,29613808 10,94626359 0,0036322 0,16982474 protein, 1C 419 3148 HMGB2 high mobility group box 2 -0,3990104 11,60199189 0,0036643 0,1701567

420 975 CD81 CD81 molecule -0,1254023 13,82845116 0,0036699 0,1701567 421 64785 GINS3 GINS complex subunit 3 -0,517261 5,679306067 0,003673 0,1701567 (Psf3 homolog) 422 2162 F13A1 coagulation factor XIII, A1 0,65333843 10,77739257 0,0036741 0,1701567 polypeptide 423 595 CCND1 cyclin D1 0,59768774 9,740451261 0,0036926 0,17042971 424 3476 IGBP1 immunoglobulin (CD79A) -0,2075784 10,75562522 0,0037137 0,17042971 binding protein 1

425 7128 TNFAIP3 tumor necrosis factor, 0,44711705 6,523366238 0,0037138 0,17042971 alpha-induced protein 3

426 143941 TTC36 tetratricopeptide repeat -1,1769093 3,664794798 0,0037427 0,17042971 domain 36 427 65080 MRPL44 mitochondrial ribosomal -0,1989304 7,727002129 0,0037521 0,17042971 protein L44 428 84146 ZNF644 zinc finger protein 644 -0,2000846 6,032448838 0,0037549 0,17042971 429 26092 TOR1AIP torsin A interacting protein -0,1757323 8,607575794 0,0037654 0,17042971 1 1 430 4779 NFE2L1 nuclear factor, erythroid 2- 0,28926038 10,56931004 0,0037677 0,17042971 like 1 431 6038 RNASE4 ribonuclease, RNase A -0,2661969 12,19956277 0,0037844 0,17042971 family, 4 432 84706 GPT2 glutamic pyruvate -0,5589741 7,552093305 0,0037887 0,17042971 transaminase (alanine aminotransferase) 2 433 81888 HYI hydroxypyruvate -0,3431452 8,646310615 0,0038022 0,17042971 isomerase (putative) 434 2281 FKBP1B FK506 binding protein 1B, 0,24708775 5,716421457 0,0038029 0,17042971 12.6 kDa 435 80206 FHOD3 formin homology 2 -1,1251052 3,522171534 0,0038139 0,17042971 domain containing 3 436 5660 PSAP prosaposin 0,20918521 12,48259877 0,0038154 0,17042971 437 5092 PCBD1 pterin-4 alpha- -0,4456297 7,226538883 0,0038217 0,17042971 carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha

438 23166 STAB1 stabilin 1 0,46465356 7,463556085 0,0038242 0,17042971 439 11067 C10orf10 chromosome 10 open -0,8495207 9,740781453 0,0038359 0,17042971 reading frame 10 440 23028 KDM1A lysine (K)-specific -0,2384525 7,247493417 0,0038436 0,17042971 demethylase 1A 441 54206 ERRFI1 ERBB receptor feedback -0,6336863 10,4152518 0,0038457 0,17042971 inhibitor 1 442 123207 C15orf40 chromosome 15 open -0,1485395 9,297857715 0,0038586 0,17061787 reading frame 40 443 56997 ADCK3 aarF domain containing -0,3019208 8,734265124 0,0038748 0,17094677 kinase 3 444 51406 NOL7 nucleolar protein 7, 27kDa -0,1607559 11,10354414 0,0039089 0,17205997

445 80763 C12orf39 chromosome 12 open -1,6845174 4,658742457 0,0039543 0,17322532 reading frame 39 446 64976 MRPL40 mitochondrial ribosomal -0,1311546 10,08951348 0,0039606 0,17322532 protein L40 447 9583 ENTPD4 ectonucleoside 0,1710447 5,537173316 0,0039619 0,17322532 triphosphate diphosphohydrolase 4 448 9249 DHRS3 dehydrogenase/reductase -0,3736713 11,38086198 0,0039805 0,17332819 (SDR family) member 3

449 1856 DVL2 dishevelled segment -0,0880019 6,728730582 0,0039939 0,17332819 polarity protein 2 450 120114 FAT3 FAT atypical cadherin 3 -0,8126641 5,294032736 0,0040008 0,17332819 451 55266 TMEM19 transmembrane protein 19 0,20050068 7,679656456 0,0040206 0,17332819

452 57544 TXNDC16 thioredoxin domain -0,2231209 8,956176724 0,0040251 0,17332819 containing 16 453 1E+08 TSTD1 thiosulfate -0,3167138 9,898775166 0,004026 0,17332819 sulfurtransferase (rhodanese)-like domain containing 1 454 11325 DDX42 DEAD (Asp-Glu-Ala-Asp) -0,1174152 8,2337006 0,0040264 0,17332819 box helicase 42 455 6282 S100A11 S100 calcium binding 0,40749068 11,24295117 0,0040731 0,17416435 protein A11 456 8536 CAMK1 calcium/calmodulin- -0,2331871 7,47038251 0,0040763 0,17416435 dependent protein kinase I

457 51081 MRPS7 mitochondrial ribosomal -0,1937159 8,581228435 0,0040868 0,17416435 protein S7 458 39 ACAT2 acetyl-CoA -0,3848604 8,475609141 0,0040926 0,17416435 acetyltransferase 2 459 1743 DLST dihydrolipoamide S- -0,2720756 9,99083625 0,0040981 0,17416435 succinyltransferase (E2 component of 2-oxo- glutarate complex) 460 55014 STX17 syntaxin 17 -0,1151137 6,457151765 0,004101 0,17416435 461 8971 H1FX H1 histone family, -0,1692734 8,40968352 0,0041082 0,17416435 member X 462 84695 LOXL3 lysyl oxidase-like 3 0,29270066 5,469383141 0,0041396 0,17511959 463 7422 VEGFA vascular endothelial -0,4932006 6,415002387 0,0041832 0,17657974 growth factor A 464 84912 SLC35B4 solute carrier family 35 0,239695 6,780747142 0,004195 0,17669427 (UDP-xylose/UDP-N- acetylglucosamine transporter), member B4

465 666 BOK BCL2-related ovarian killer -0,4143337 10,314403 0,0042138 0,17690895

466 4175 MCM6 minichromosome -0,1924207 3,833859381 0,0042354 0,17690895 maintenance complex component 6 467 23708 GSPT2 G1 to S phase transition 2 -0,1391377 8,391432997 0,0042357 0,17690895

468 23266 LPHN2 latrophilin 2 -0,2016635 10,16760447 0,0042367 0,17690895 469 5202 PFDN2 prefoldin subunit 2 -0,1856716 9,918148457 0,0042453 0,17690895 470 79705 LRRK1 leucine-rich repeat kinase 0,40958429 4,132737972 0,0042871 0,17712007 1 471 286205 SCAI suppressor of cancer cell -0,2591608 4,962391037 0,004294 0,17712007 invasion 472 10060 ABCC9 ATP-binding cassette, sub- -0,3526006 4,279310939 0,0042946 0,17712007 family C (CFTR/MRP), member 9 473 10765 KDM5B lysine (K)-specific -0,201438 7,45707686 0,0043165 0,17712007 demethylase 5B 474 114803 MYSM1 Myb-like, SWIRM and MPN -0,1391738 3,78850856 0,0043187 0,17712007 domains 1 475 79161 TMEM24 transmembrane protein -0,2388202 9,869078507 0,0043298 0,17712007 3 243, mitochondrial

476 10553 HTATIP2 HIV-1 Tat interactive 0,23067996 7,002827676 0,0043313 0,17712007 protein 2, 30kDa 477 9184 BUB3 BUB3 mitotic checkpoint -0,1020611 9,824631456 0,0043378 0,17712007 protein 478 55737 VPS35 vacuolar protein sorting 35 -0,0811777 10,71713055 0,0043381 0,17712007 homolog (S. cerevisiae)

479 9334 B4GALT5 UDP-Gal:betaGlcNAc beta 0,23955365 9,363680603 0,004341 0,17712007 1,4- galactosyltransferase, polypeptide 5

480 375484 SIMC1 SUMO-interacting motifs -0,2268581 7,355335281 0,0043726 0,17801546 containing 1 481 1071 CETP cholesteryl ester transfer -0,9171684 3,664765345 0,0043812 0,17801546 protein, plasma

482 1312 COMT catechol-O- 0,189052 7,306339595 0,0043907 0,17803291 methyltransferase 483 51147 ING4 inhibitor of growth family, -0,1872324 7,417464618 0,0044083 0,1783536 member 4 484 5725 PTBP1 polypyrimidine tract 0,10199009 9,925428775 0,0044169 0,1783536 binding protein 1 485 26136 TES testis derived transcript (3 0,36483801 7,57024469 0,0044479 0,17905994 LIM domains)

486 4255 MGMT O-6-methylguanine-DNA -0,1571292 7,809987662 0,0044621 0,17905994 methyltransferase 487 4240 MFGE8 milk fat globule-EGF factor 0,235778 7,790772634 0,0044742 0,17905994 8 protein 488 90102 PHLDB2 pleckstrin homology-like -0,2480175 8,088986038 0,0044773 0,17905994 domain, family B, member 2 489 338 APOB apolipoprotein B -0,4662475 4,696331086 0,0044847 0,17905994 490 60560 NAA35 N(alpha)-acetyltransferase -0,143769 7,534889829 0,0044893 0,17905994 35, NatC auxiliary subunit

491 4217 MAP3K5 mitogen-activated protein -0,5001637 10,11588292 0,0045301 0,18022497 kinase kinase kinase 5

492 51637 C14orf16 chromosome 14 open -0,0864453 12,69210443 0,004539 0,18022497 6 reading frame 166 493 10212 DDX39A DEAD (Asp-Glu-Ala-Asp) 0,13929305 7,993198003 0,0045534 0,18022497 box polypeptide 39A

494 79147 FKRP fukutin related protein 0,04572836 3,055299669 0,0045886 0,18022497 495 114885 OSBPL11 oxysterol binding protein- 0,21816791 8,542011051 0,004592 0,18022497 like 11 496 283345 RPL13P5 ribosomal protein L13 0,19424299 3,798109018 0,0045954 0,18022497 pseudogene 5 497 79009 DDX50 DEAD (Asp-Glu-Ala-Asp) -0,1779978 9,375303507 0,0045977 0,18022497 box polypeptide 50

498 1397 CRIP2 cysteine-rich protein 2 0,49324016 6,234596018 0,0045988 0,18022497 499 5139 PDE3A phosphodiesterase 3A, -0,4257385 5,749214607 0,0046015 0,18022497 cGMP-inhibited 500 9697 TRAM2 translocation associated 0,28508258 6,417646768 0,0046186 0,18049954 membrane protein 2

501 80705 TSGA10 testis specific, 10 -0,7452164 6,003994592 0,004634 0,18049954 502 10618 TGOLN2 trans-golgi network 0,12018488 8,467534755 0,0046362 0,18049954 protein 2 503 7923 HSD17B8 hydroxysteroid (17-beta) -0,30689 7,508199499 0,0046638 0,18118455 dehydrogenase 8 504 1027 CDKN1B cyclin-dependent kinase -0,2271597 11,32377484 0,0046724 0,18118455 inhibitor 1B (p27, Kip1)

505 25983 NGDN neuroguidin, EIF4E binding -0,1501649 9,275797685 0,0047119 0,18235495 protein 506 93436 ARMC6 armadillo repeat 0,24294821 4,459678902 0,0047763 0,18366417 containing 6 507 10269 ZMPSTE2 zinc metallopeptidase 0,16933764 10,93366375 0,0047825 0,18366417 4 STE24 508 9572 NR1D1 nuclear receptor subfamily -0,4300928 6,899456987 0,0047827 0,18366417 1, group D, member 1

509 2788 GNG7 guanine nucleotide binding -0,4701321 2,895194325 0,0047856 0,18366417 protein (G protein), gamma 7 510 94120 SYTL3 synaptotagmin-like 3 -0,4582978 4,456327147 0,0047958 0,18366417 511 5607 MAP2K5 mitogen-activated protein -0,2381831 6,757826493 0,0048104 0,18366417 kinase kinase 5 512 5936 RBM4 RNA binding motif protein -0,1995623 8,220178224 0,0048115 0,18366417 4 513 340061 TMEM17 transmembrane protein 0,2423555 3,394376985 0,0048256 0,18384396 3 173 514 1149 CIDEA cell death-inducing DFFA- -0,7572149 10,85406598 0,0048533 0,18440397 like effector a 515 10160 FARP1 FERM, RhoGEF (ARHGEF) 0,26117186 7,331232681 0,0048592 0,18440397 and pleckstrin domain protein 1 (chondrocyte- derived)

516 347733 TUBB2B tubulin, beta 2B class IIb 1,11153436 4,25396134 0,0048701 0,18446079

517 123036 TC2N tandem C2 domains, -0,4460009 6,149006765 0,0048949 0,18497714 nuclear 518 161 AP2A2 adaptor-related protein 0,14627706 9,183293525 0,0049027 0,18497714 complex 2, alpha 2 subunit

519 4702 NDUFA8 NADH dehydrogenase -0,203623 10,32523258 0,0049201 0,18511516 (ubiquinone) 1 alpha subcomplex, 8, 19kDa 520 3182 HNRNPA heterogeneous nuclear 0,27036726 10,41305491 0,0049302 0,18511516 B ribonucleoprotein A/B 521 389114 ZNF662 zinc finger protein 662 -0,2453256 5,009934213 0,0049348 0,18511516 522 56985 ADPRM ADP-ribose/CDP-alcohol -0,1920114 5,340708542 0,0049646 0,1858763 diphosphatase, manganese-dependent 523 9852 EPM2AIP EPM2A (laforin) interacting -0,1437978 7,405997758 0,0049999 0,18625308 1 protein 1 524 11261 CHP1 calcineurin-like EF-hand -0,3163459 10,23283173 0,0050003 0,18625308 protein 1 525 6335 SCN9A sodium channel, voltage- 0,39410299 4,143153416 0,0050196 0,18625308 gated, type IX, alpha subunit 526 11001 SLC27A2 solute carrier family 27 -2,0729963 3,568317971 0,0050197 0,18625308 (fatty acid transporter), member 2 527 493753 COA5 cytochrome c oxidase -0,1496364 8,950298544 0,0050375 0,18625308 assembly factor 5 528 25782 RAB3GAP RAB3 GTPase activating -0,1199843 9,17392657 0,0050427 0,18625308 2 protein subunit 2 (non- catalytic) 529 6597 SMARCA SWI/SNF related, matrix 0,14529819 6,49337456 0,0050504 0,18625308 4 associated, actin dependent regulator of chromatin, subfamily a, member 4 530 6035 RNASE1 ribonuclease, RNase A 0,37224822 12,09664078 0,0050509 0,18625308 family, 1 (pancreatic) 531 5218 CDK14 cyclin-dependent kinase -0,1389254 5,450785125 0,005068 0,18653332 14 532 91860 CALML4 calmodulin-like 4 0,40103436 5,504626074 0,0050964 0,1872268 533 1351 COX8A cytochrome c oxidase -0,1684865 11,85442677 0,0051332 0,1882245 subunit VIIIA (ubiquitous)

534 55074 OXR1 oxidation resistance 1 -0,19043 10,71611585 0,0051495 0,18846695 535 3992 FADS1 fatty acid desaturase 1 -1,0678741 9,581488984 0,0051611 0,18854046 536 5311 PKD2 polycystic kidney disease 2 0,2363234 10,51571588 0,0051881 0,18904766 (autosomal dominant)

537 9868 TOMM70 translocase of outer -0,1088473 9,405194714 0,0051944 0,18904766 A mitochondrial membrane 70 homolog A (S. cerevisiae) 538 5164 PDK2 pyruvate dehydrogenase -0,3254895 5,687859722 0,0052404 0,19009801 kinase, isozyme 2

539 539 ATP5O ATP synthase, H+ -0,1160707 13,67288514 0,0052427 0,19009801 transporting, mitochondrial F1 complex, O subunit 540 3486 IGFBP3 insulin-like growth factor -0,5444072 11,24187791 0,0052558 0,19021959 binding protein 3 541 26355 FAM162 family with sequence -0,1725936 11,59849736 0,005273 0,19048913 A similarity 162, member A

542 5306 PITPNA phosphatidylinositol 0,16046454 8,047443241 0,0052923 0,19050326 transfer protein, alpha 543 123283 TARSL2 threonyl-tRNA synthetase- -0,1672095 6,106413063 0,0052928 0,19050326 like 2 544 64860 ARMCX5 armadillo repeat -0,2369614 7,730196626 0,0053159 0,19098056 containing, X-linked 5 545 55280 CWF19L1 CWF19-like 1, cell cycle -0,1178307 4,188890274 0,0053533 0,1919327 control (S. pombe) 546 5274 SERPINI1 serpin peptidase inhibitor, -0,4810002 8,613646399 0,0053763 0,1919327 clade I (neuroserpin), member 1 547 3310 HSPA6 heat shock 70kDa protein 0,63431852 5,221211819 0,0053795 0,1919327 6 (HSP70B') 548 7381 UQCRB ubiquinol-cytochrome c -0,1659081 7,539987741 0,0053825 0,1919327 reductase binding protein

549 8428 STK24 serine/threonine kinase 24 -0,2892003 10,84861833 0,0053986 0,1919327

550 10395 DLC1 deleted in liver cancer 1 -0,1418832 9,542848459 0,0054013 0,1919327

551 1457 CSNK2A1 casein kinase 2, alpha 1 -0,2542798 7,392174387 0,0054256 0,19244795 polypeptide 552 38 ACAT1 acetyl-CoA -0,2339939 8,941226212 0,0054567 0,19261433 acetyltransferase 1 553 23429 RYBP RING1 and YY1 binding -0,1718321 9,0017784 0,0054593 0,19261433 protein 554 55902 ACSS2 acyl-CoA synthetase short- -0,4299328 10,76961773 0,0054599 0,19261433 chain family member 2

555 11160 ERLIN2 ER lipid raft associated 2 -0,1553419 8,185729722 0,0054726 0,19271271

556 83439 TCF7L1 transcription factor 7-like -0,2320492 8,478776652 0,0054854 0,19281749 1 (T-cell specific, HMG- box) 557 6576 SLC25A1 solute carrier family 25 -0,4393443 8,626622591 0,0055012 0,19302492 (mitochondrial carrier; citrate transporter), member 1 558 427 ASAH1 N-acylsphingosine 0,26404763 13,26781229 0,0055329 0,19377939 amidohydrolase (acid ceramidase) 1 559 2908 NR3C1 nuclear receptor subfamily -0,2453825 11,31183219 0,0055425 0,19377939 3, group C, member 1 (glucocorticoid receptor)

560 26509 MYOF myoferlin 0,28506803 9,824448385 0,0055912 0,19501224 561 118980 SFXN2 sideroflexin 2 -0,2379542 5,404696498 0,0055977 0,19501224 562 9520 NPEPPS aminopeptidase -0,1605268 9,409012815 0,0056111 0,19512883 puromycin sensitive 563 51144 HSD17B1 hydroxysteroid (17-beta) -0,2921363 11,39131234 0,0056273 0,19534745 2 dehydrogenase 12

564 5189 PEX1 peroxisomal biogenesis -0,205385 7,962890555 0,0056528 0,19588299 factor 1 565 221895 JAZF1 JAZF zinc finger 1 0,18562131 8,039221606 0,005679 0,19613021 566 253559 CADM2 cell adhesion molecule 2 -0,5668609 4,373377852 0,00568 0,19613021

567 128637 TBC1D20 TBC1 domain family, -0,1295158 6,962834182 0,0056967 0,19623389 member 20 568 58477 SRPRB signal recognition particle 0,18118499 6,961641735 0,0057031 0,19623389 receptor, B subunit

569 11051 NUDT21 nudix (nucleoside -0,1583489 7,394847602 0,0057468 0,19739018 diphosphate linked moiety X)-type motif 21

570 145270 PRIMA1 proline rich membrane -0,4175396 5,881489909 0,0057598 0,19749063 anchor 1 571 284021 MILR1 mast cell immunoglobulin- 0,55905786 6,251091172 0,005824 0,1985593 like receptor 1

572 1939 EIF2D eukaryotic translation -0,1320446 9,445832295 0,0058251 0,1985593 initiation factor 2D 573 22949 PTGR1 prostaglandin reductase 1 -0,2727624 10,31400203 0,0058265 0,1985593

574 714 C1QC complement component 0,64096484 8,996946009 0,0058316 0,1985593 1, q subcomponent, C chain 575 121665 SPPL3 signal peptide peptidase -0,0836707 8,371163751 0,0058707 0,19927577 like 3 576 25805 BAMBI BMP and activin 0,5901402 4,660583544 0,0058981 0,19927577 membrane-bound inhibitor 577 6629 SNRPB2 small nuclear -0,1085081 11,55093302 0,0059064 0,19927577 ribonucleoprotein polypeptide B 578 10840 ALDH1L1 aldehyde dehydrogenase 1 -0,5499617 8,976136132 0,0059111 0,19927577 family, member L1

579 57124 CD248 CD248 molecule, 0,45566738 10,29530797 0,0059175 0,19927577 endosialin 580 4715 NDUFB9 NADH dehydrogenase -0,1739965 11,41912009 0,0059223 0,19927577 (ubiquinone) 1 beta subcomplex, 9, 22kDa 581 10379 IRF9 interferon regulatory 0,31508964 8,091640081 0,0059334 0,19927577 factor 9 582 11112 HIBADH 3-hydroxyisobutyrate -0,2458512 10,55516833 0,0059342 0,19927577 dehydrogenase 583 55262 C7orf43 chromosome 7 open 0,26905651 5,013234888 0,0060077 0,20116694 reading frame 43 584 1491 CTH cystathionase -0,4744432 5,744100093 0,0060111 0,20116694 (cystathionine gamma- lyase) 585 5795 PTPRJ protein tyrosine 0,2465536 4,447343025 0,0060221 0,20119008 phosphatase, receptor type, J 586 81493 SYNC syncoilin, intermediate 0,55851412 9,058295453 0,0060918 0,20239867 filament protein 587 55803 ADAP2 ArfGAP with dual PH 0,63432386 7,276817526 0,0060965 0,20239867 domains 2 588 79888 LPCAT1 lysophosphatidylcholine 0,34049745 7,556912343 0,0061085 0,20239867 acyltransferase 1 589 5324 PLAG1 pleiomorphic adenoma -0,3135898 2,942714767 0,0061176 0,20239867 gene 1 590 56886 UGGT1 UDP-glucose glycoprotein 0,16624842 5,412154396 0,0061186 0,20239867 glucosyltransferase 1

591 10142 AKAP9 A kinase (PRKA) anchor -0,2318585 9,500283078 0,0061295 0,20239867 protein 9 592 51204 TACO1 translational activator of -0,2035511 6,789939615 0,0061308 0,20239867 mitochondrially encoded cytochrome c oxidase I

593 23240 KIAA092 KIAA0922 -0,4521173 7,65830275 0,0061467 0,20258092 2 594 27332 ZNF638 zinc finger protein 638 -0,0920219 9,353791374 0,0061642 0,20281734 595 64776 C11orf1 chromosome 11 open -0,3381545 7,843163148 0,0061749 0,20282733 reading frame 1 596 517 ATP5G2 ATP synthase, H+ -0,1650385 11,44160944 0,0061883 0,20292604 transporting, mitochondrial Fo complex, subunit C2 (subunit 9)

597 27314 RAB30 RAB30, member RAS 0,29702773 7,367492795 0,0062045 0,20304541 oncogene family 598 3654 IRAK1 interleukin-1 receptor- 0,26988789 5,337042735 0,0062127 0,20304541 associated kinase 1 599 653784 MZT2A mitotic spindle organizing -0,1766319 9,042659411 0,0062422 0,20324009 protein 2A 600 8975 USP13 ubiquitin specific -0,3858318 6,361529291 0,0062469 0,20324009 peptidase 13 (isopeptidase T-3) 601 7408 VASP vasodilator-stimulated 0,27341317 7,393626747 0,0062499 0,20324009 phosphoprotein 602 4076 CAPRIN1 cell cycle associated -0,102169 7,325461264 0,0062766 0,20377115 protein 1 603 114876 OSBPL1A oxysterol binding protein- -0,1999888 12,05251861 0,006294 0,20399519 like 1A 604 222484 LNX2 ligand of numb-protein X 2 -0,2658258 8,063213627 0,006343 0,20468851

605 284119 PTRF polymerase I and 0,25480163 11,45223936 0,0063454 0,20468851 transcript release factor

606 26037 SIPA1L1 signal-induced 0,37399133 5,219058029 0,0063468 0,20468851 proliferation-associated 1 like 1 607 348094 ANKDD1 ankyrin repeat and death 0,57233289 7,956696784 0,0063681 0,20477242 A domain containing 1A

608 4478 MSN moesin 0,19281604 9,664260499 0,0063703 0,20477242 609 7385 UQCRC2 ubiquinol-cytochrome c -0,2238657 11,77769195 0,0064352 0,20507482 reductase core protein II

610 374659 HDDC3 HD domain containing 3 -0,2712972 8,211424642 0,0064401 0,20507482 611 9782 MATR3 matrin 3 -0,1040429 8,261894231 0,006441 0,20507482 612 1955 MEGF9 multiple EGF-like-domains 0,27508743 7,43453412 0,0064412 0,20507482 9 613 2054 STX2 syntaxin 2 0,23493215 7,767467095 0,0064493 0,20507482 614 113177 IZUMO4 IZUMO family member 4 -0,2435807 2,399407281 0,006452 0,20507482

615 90120 C9orf69 chromosome 9 open 0,12137466 7,025652125 0,0064532 0,20507482 reading frame 69 616 4329 ALDH6A1 aldehyde dehydrogenase 6 -0,5388668 9,230960601 0,0064979 0,20615925 family, member A1

617 4695 NDUFA2 NADH dehydrogenase -0,1148991 10,68237794 0,0065567 0,20714973 (ubiquinone) 1 alpha subcomplex, 2, 8kDa 618 81573 ANKRD13 ankyrin repeat domain 13C -0,101847 7,264636235 0,0065638 0,20714973 C 619 4134 MAP4 microtubule-associated 0,18577487 9,306930091 0,0065697 0,20714973 protein 4 620 9445 ITM2B integral membrane protein -0,0609151 14,00789845 0,0065715 0,20714973 2B 621 54876 DCAF16 DDB1 and CUL4 associated -0,1492532 7,803325467 0,006583 0,20717821 factor 16 622 1030 CDKN2B cyclin-dependent kinase 0,36955056 8,68221749 0,0066354 0,20765992 inhibitor 2B (p15, inhibits CDK4) 623 4810 NHS Nance-Horan syndrome -0,2577789 5,01856864 0,0066365 0,20765992 (congenital cataracts and dental anomalies) 624 414777 HCG18 HLA complex group 18 -0,1425386 3,364884927 0,0066382 0,20765992 (non-protein coding) 625 1E+08 SNHG8 small nucleolar RNA host -0,2206968 9,37181055 0,0066458 0,20765992 gene 8 (non-protein coding) 626 55114 ARHGAP Rho GTPase activating 0,14925807 9,688122632 0,0066514 0,20765992 17 protein 17 627 3241 HPCAL1 hippocalcin-like 1 0,13319118 5,299389445 0,0066909 0,20855871 628 2764 GMFB glia maturation factor, 0,21312364 7,316357384 0,0067174 0,20872197 beta 629 55832 CAND1 cullin-associated and -0,0886335 9,126240516 0,0067175 0,20872197 neddylation-dissociated 1 630 23483 TGDS TDP-glucose 4,6- -0,2272745 8,347122806 0,0067787 0,21008807 dehydratase 631 54539 NDUFB11 NADH dehydrogenase -0,1517455 11,13794783 0,0067878 0,21008807 (ubiquinone) 1 beta subcomplex, 11, 17.3kDa

632 28959 TMEM17 transmembrane protein 0,34787115 7,23010471 0,0067955 0,21008807 6B 176B 633 121227 LRIG3 leucine-rich repeats and -0,2489987 8,39798115 0,0068044 0,21008807 immunoglobulin-like domains 3 634 90637 ZFAND2A zinc finger, AN1-type -0,1563336 8,745203746 0,0068161 0,21011614 domain 2A 635 23499 MACF1 microtubule-actin 0,18609579 10,22226534 0,0068544 0,21051426 crosslinking factor 1 636 29775 CARD10 caspase recruitment 0,24199323 5,67274982 0,0068571 0,21051426 domain family, member 10

637 441951 ZFAS1 ZNFX1 antisense RNA 1 -0,2412564 11,11369888 0,0068613 0,21051426 638 79746 ECHDC3 enoyl CoA hydratase -0,5277607 11,33698541 0,0068733 0,21055215 domain containing 3 639 727910 TLCD2 TLC domain containing 2 0,4067687 9,83057608 0,0069053 0,21120028

640 1E+08 ZNF587B zinc finger protein 587B 0,24144629 6,705806568 0,0069718 0,2124769

641 60370 AVPI1 arginine vasopressin- -0,3624449 8,919236854 0,0069784 0,2124769 induced 1 642 972 CD74 CD74 molecule, major 0,28278955 6,827708758 0,0069796 0,2124769 histocompatibility complex, class II invariant chain 643 8798 DYRK4 dual-specificity tyrosine-(Y)- -0,1210368 5,662366116 0,0069942 0,21258812 phosphorylation regulated kinase 4

644 11116 FGFR1OP FGFR1 oncogene partner -0,1709616 6,699583419 0,0070134 0,21284046

645 1E+08 PET117 PET117 homolog (S. -0,1391864 8,34922214 0,0070393 0,21299683 cerevisiae) 646 200185 KRTCAP2 keratinocyte associated -0,1266393 11,82978635 0,0070403 0,21299683 protein 2 647 55178 RNMTL1 RNA methyltransferase -0,2467566 7,589788815 0,0070597 0,213253 like 1 648 5507 PPP1R3C protein phosphatase 1, 0,267847 7,700804715 0,0071546 0,21578633 regulatory subunit 3C 649 10613 ERLIN1 ER lipid raft associated 1 0,12748524 7,76125198 0,007176 0,21609849

650 23212 RRS1 RRS1 ribosome biogenesis 0,20648144 8,049956903 0,0072011 0,21620284 regulator homolog (S. cerevisiae) 651 4277 MICB MHC class I polypeptide- 0,56909638 5,737913101 0,0072039 0,21620284 related sequence B

652 4731 NDUFV3 NADH dehydrogenase -0,1611506 7,891647242 0,0072127 0,21620284 (ubiquinone) flavoprotein 3, 10kDa 653 7529 YWHAB tyrosine 3- 0,14330267 12,54005607 0,0072366 0,21658697 monooxygenase/tryptoph an 5-monooxygenase activation protein, beta

654 60485 SAV1 salvador homolog 1 -0,2492222 9,62689258 0,0072576 0,21688552 (Drosophila) 655 8805 TRIM24 tripartite motif containing -0,2208096 8,245665727 0,00727 0,21692458 24 656 5336 PLCG2 phospholipase C, gamma 2 0,25328283 5,394207777 0,0073082 0,21749462 (phosphatidylinositol- specific)

657 6913 TBX15 T-box 15 -0,3465663 8,533001673 0,0073286 0,21749462 658 54625 PARP14 poly (ADP-ribose) 0,31714098 7,562113909 0,0073328 0,21749462 polymerase family, member 14 659 22821 RASA3 RAS p21 protein activator 0,22937331 3,756433025 0,007343 0,21749462 3 660 80318 GKAP1 G kinase anchoring protein -0,3525183 8,815051538 0,0073448 0,21749462 1 661 10008 KCNE3 potassium voltage-gated 0,3632793 5,275754501 0,0073584 0,21756883 channel, Isk-related family, member 3

662 2316 FLNA filamin A, alpha 0,28715869 9,09296395 0,0074065 0,21851596 663 23417 MLYCD malonyl-CoA -0,2712366 7,1751321 0,0074128 0,21851596 decarboxylase 664 23014 FBXO21 F-box protein 21 -0,1615017 8,905494345 0,0074251 0,21854823 665 253782 CERS6 ceramide synthase 6 -0,1533767 6,448090548 0,0075637 0,22229331 666 84274 COQ5 coenzyme Q5 homolog, -0,157509 9,719109792 0,007618 0,2234194 methyltransferase (S. cerevisiae) 667 115330 GPR146 G protein-coupled -0,3835727 8,748015536 0,0076295 0,2234194 receptor 146 668 55283 MCOLN3 mucolipin 3 -0,6595823 7,751034398 0,0076445 0,2234194

669 92293 TMEM13 transmembrane protein -0,3751284 10,15662857 0,0076565 0,2234194 2C 132C 670 3625 INHBB inhibin, beta B 0,31598169 10,75684498 0,007667 0,2234194 671 10628 TXNIP thioredoxin interacting -0,3238073 13,47410065 0,007678 0,2234194 protein 672 301 ANXA1 annexin A1 0,25745367 13,97228434 0,0076952 0,2234194 673 1E+08 OSER1- OSER1 antisense RNA 1 -0,3203131 5,404049893 0,0076991 0,2234194 AS1 (head to head) 674 902 CCNH cyclin H -0,2753696 10,27285835 0,0077592 0,2234194 675 641638 SNHG6 small nucleolar RNA host -0,1943275 13,07524472 0,0077668 0,2234194 gene 6 (non-protein coding) 676 80301 PLEKHO2 pleckstrin homology 0,40750392 8,121500241 0,0077745 0,2234194 domain containing, family O member 2 677 116362 RBP7 retinol binding protein 7, -0,4916001 12,17590522 0,0077988 0,2234194 cellular 678 2350 FOLR2 folate receptor 2 (fetal) 0,46037177 8,629834998 0,0078081 0,2234194 679 23558 WBP2 WW domain binding -0,3040735 7,591177622 0,0078152 0,2234194 protein 2 680 7469 NELFA negative elongation factor -0,1677347 7,256142346 0,0078171 0,2234194 complex member A

681 4982 TNFRSF1 tumor necrosis factor 0,95835064 4,053448535 0,007823 0,2234194 1B receptor superfamily, member 11b 682 64756 ATPAF1 ATP synthase -0,2315363 10,81670917 0,0078259 0,2234194 mitochondrial F1 complex assembly factor 1

683 25945 PVRL3 poliovirus receptor-related -0,3172066 7,230607792 0,0078336 0,2234194 3 684 54407 SLC38A2 solute carrier family 38, 0,24681258 11,4220915 0,0078354 0,2234194 member 2 685 90864 SPSB3 splA/ryanodine receptor -0,1565018 7,526792646 0,007841 0,2234194 domain and SOCS box containing 3 686 5476 CTSA cathepsin A 0,19102731 10,09153582 0,0078431 0,2234194 687 51184 GPN3 GPN-loop GTPase 3 -0,1779783 9,558071177 0,0078535 0,2234194 688 57103 C12orf5 chromosome 12 open 0,5789604 7,17402193 0,0078866 0,2234743 reading frame 5 689 81689 ISCA1 iron-sulfur cluster -0,1090844 10,60589009 0,0078867 0,2234743 assembly 1 690 152189 CMTM8 CKLF-like MARVEL -0,3810593 7,336671157 0,0078897 0,2234743 transmembrane domain containing 8 691 65005 MRPL9 mitochondrial ribosomal -0,1184571 9,524543672 0,0079086 0,22357657 protein L9 692 51531 C9orf156 chromosome 9 open -0,231882 6,684986628 0,0079162 0,22357657 reading frame 156 693 25941 TPGS2 tubulin polyglutamylase 0,30007228 9,038937469 0,0079299 0,22363818 complex subunit 2

694 283316 CD163L1 CD163 molecule-like 1 0,44837689 5,785195641 0,0079482 0,22383338 695 79991 OBFC1 oligonucleotide/oligosacch -0,1719861 6,537681229 0,0079774 0,22427799 aride-binding fold containing 1 696 54840 APTX aprataxin -0,1626899 6,524661962 0,007987 0,22427799 697 128387 TATDN3 TatD DNase domain -0,1644609 7,671377524 0,0080179 0,22475193 containing 3 698 5166 PDK4 pyruvate dehydrogenase -0,3668961 11,73923515 0,0080352 0,22475193 kinase, isozyme 4

699 50854 C6orf48 chromosome 6 open -0,1336251 10,57048622 0,0080531 0,22475193 reading frame 48 700 1E+08 LOC1002 uncharacterized -0,1633576 5,748031526 0,0080552 0,22475193 89361 LOC100289361 701 57493 HEG1 heart development protein 0,28997718 9,284805089 0,0080624 0,22475193 with EGF-like domains 1

702 55780 ERMARD ER membrane-associated -0,1485523 8,012737457 0,0080802 0,22475193 RNA degradation

703 7559 ZNF12 zinc finger protein 12 -0,1888215 8,250408401 0,0080952 0,22475193 704 25828 TXN2 thioredoxin 2 -0,1233984 8,999599746 0,0081036 0,22475193 705 8406 SRPX sushi-repeat containing -0,3577604 13,01959908 0,0081197 0,22475193 protein, X-linked 706 5926 ARID4A AT rich interactive domain -0,222788 8,2633508 0,0081292 0,22475193 4A (RBP1-like) 707 2954 GSTZ1 glutathione S-transferase -0,2954543 7,359868117 0,0081306 0,22475193 zeta 1 708 8605 PLA2G4C phospholipase A2, group 0,3631767 6,476103456 0,0081419 0,22475193 IVC (cytosolic, calcium- independent) 709 1E+08 HOTAIR HOXA transcript antisense 0,20911883 7,424938754 0,0081998 0,22603311 M1 RNA, myeloid-specific 1

710 1052 CEBPD CCAAT/enhancer binding -0,4463371 11,48792112 0,0082258 0,22642952 protein (C/EBP), delta

711 51616 TAF9B TAF9B RNA polymerase II, -0,2213993 6,978643349 0,0082456 0,22656481 TATA box binding protein (TBP)-associated factor, 31kDa

712 8644 AKR1C3 aldo-keto reductase family 0,30073134 13,56048975 0,0082539 0,22656481 1, member C3 713 59343 SENP2 SUMO1/sentrin/SMT3 -0,2625707 6,343545232 0,0083332 0,22827874 specific peptidase 2 714 387066 SNHG5 small nucleolar RNA host -0,2460087 12,9841446 0,0083612 0,22827874 gene 5 (non-protein coding) 715 81602 CDADC1 cytidine and dCMP -0,1604241 5,86879949 0,0083614 0,22827874 deaminase domain containing 1 716 80176 SPSB1 splA/ryanodine receptor -0,3654586 6,440694531 0,0083631 0,22827874 domain and SOCS box containing 1 717 115992 RNF166 ring finger protein 166 0,17255676 6,590738667 0,0084476 0,22947454 718 6612 SUMO3 small ubiquitin-like 0,13768117 9,96702794 0,0084513 0,22947454 modifier 3 719 11275 KLHL2 kelch-like family member 2 0,14684421 9,893419231 0,0084552 0,22947454

720 397 ARHGDIB Rho GDP dissociation 0,33843958 7,94769504 0,0084588 0,22947454 inhibitor (GDI) beta 721 669 BPGM 2,3-bisphosphoglycerate 0,20805515 8,574451544 0,0084656 0,22947454 mutase

722 55070 DET1 de-etiolated homolog 1 -0,2058661 6,420546458 0,0084908 0,22956626 (Arabidopsis) 723 10742 RAI2 retinoic acid induced 2 -0,3879963 9,759259661 0,0084924 0,22956626 724 1846 DUSP4 dual specificity -0,7940089 8,238244868 0,0085062 0,22962071 phosphatase 4 725 1646 AKR1C2 aldo-keto reductase family 0,15576634 14,18126228 0,0085424 0,22998119 1, member C2 726 6194 RPS6 ribosomal protein S6 -0,1164641 14,7952756 0,0085431 0,22998119 727 4886 NPY1R neuropeptide Y receptor 0,38728759 12,90135503 0,0085641 0,23022866 Y1 728 10677 AVIL advillin 0,11457858 2,252465621 0,0086244 0,23113237 729 493911 PHOSPH phosphatase, orphan 2 -0,4454611 7,729087836 0,0086383 0,23113237 O2 730 3973 LHCGR luteinizing 0,67152574 5,358882394 0,0086529 0,23113237 hormone/choriogonadotro pin receptor 731 10752 CHL1 cell adhesion molecule L1- -0,3166714 4,97198818 0,0086637 0,23113237 like 732 1E+08 C8orf88 chromosome 8 open -0,4270454 4,64603955 0,0086712 0,23113237 reading frame 88 733 857 CAV1 caveolin 1, caveolae 0,05508045 14,93202026 0,0086762 0,23113237 protein, 22kDa 734 2660 MSTN myostatin -0,299164 2,689211282 0,0087101 0,23113237 735 7030 TFE3 transcription factor 0,17368678 6,875329068 0,0087114 0,23113237 binding to IGHM enhancer 3 736 254531 LPCAT4 lysophosphatidylcholine 0,29539413 3,724947475 0,0087169 0,23113237 acyltransferase 4 737 1537 CYC1 cytochrome c-1 -0,2722648 9,729845098 0,0087211 0,23113237 738 6988 TCTA T-cell leukemia 0,28866036 7,861076542 0,0087278 0,23113237 translocation altered 739 7532 YWHAG tyrosine 3- 0,15067095 14,44321799 0,0087696 0,23192495 monooxygenase/tryptoph an 5-monooxygenase activation protein, gamma

740 3563 IL3RA interleukin 3 receptor, 0,23764408 4,839036122 0,0088078 0,23262031 alpha (low affinity) 741 126669 SHE Src homology 2 domain 0,23556729 5,962599036 0,0088278 0,23283345 containing E 742 4714 NDUFB8 NADH dehydrogenase -0,1408018 9,169121893 0,0088693 0,23293265 (ubiquinone) 1 beta subcomplex, 8, 19kDa 743 79893 GGNBP2 gametogenetin binding -0,1636604 9,867134372 0,0088713 0,23293265 protein 2 744 92241 RCSD1 RCSD domain containing 1 0,32693195 6,559298373 0,0088897 0,23293265

745 7127 TNFAIP2 tumor necrosis factor, 0,24540736 5,984145746 0,0088906 0,23293265 alpha-induced protein 2

746 80204 FBXO11 F-box protein 11 -0,1468622 10,70239085 0,0089052 0,23293265 747 8721 EDF1 endothelial differentiation- -0,0927171 11,41381565 0,0089114 0,23293265 related factor 1

748 1466 CSRP2 cysteine and glycine-rich -0,4014665 10,482259 0,0089249 0,23293265 protein 2 749 7084 TK2 thymidine kinase 2, 0,17235013 7,924754818 0,0089269 0,23293265 mitochondrial 750 283078 MKX mohawk homeobox -0,6558274 3,054771029 0,0089782 0,23387594 751 57820 CCNB1IP cyclin B1 interacting -0,3040405 8,642665819 0,0089932 0,23387594 1 protein 1, E3 ubiquitin protein ligase 752 683 BST1 bone marrow stromal cell 0,41052868 6,228762539 0,0089989 0,23387594 antigen 1 753 54996 MARCH2 mitochondrial amidoxime -0,2601571 9,149879036 0,009013 0,23393021 reducing component 2

754 56894 AGPAT3 1-acylglycerol-3-phosphate 0,13143358 7,433640863 0,009032 0,2340228 O-acyltransferase 3

755 51545 ZNF581 zinc finger protein 581 -0,2876272 5,619350495 0,0090479 0,2340228 756 23023 TMCC1 transmembrane and coiled- 0,22852033 7,895572997 0,0090535 0,2340228 coil domain family 1

757 4267 CD99 CD99 molecule 0,18481006 11,21775513 0,0090644 0,2340228 758 282991 BLOC1S2 biogenesis of lysosomal 0,24543829 9,576095296 0,0090857 0,23414611 organelles complex-1, subunit 2 759 4053 LTBP2 latent transforming 0,5709099 8,722734153 0,0091026 0,23414611 growth factor beta binding protein 2 760 5569 PKIA protein kinase (cAMP- -0,3928205 3,106262436 0,009116 0,23414611 dependent, catalytic) inhibitor alpha 761 160518 DENND5 DENN/MADD domain -0,1318024 4,775018394 0,0091171 0,23414611 B containing 5B 762 22850 ADNP2 ADNP homeobox 2 -0,286326 7,76656163 0,0091458 0,23448016 763 831 CAST calpastatin -0,1019692 11,40404346 0,0091587 0,23448016 764 133584 EGFLAM EGF-like, fibronectin type -0,5889146 7,426513715 0,0091661 0,23448016 III and laminin G domains

765 25820 ARIH1 ariadne RBR E3 ubiquitin -0,1288168 7,951426753 0,0091828 0,23452296 protein ligase 1

766 85329 LGALS12 lectin, galactoside-binding, -0,5752783 10,89528666 0,0092017 0,23452296 soluble, 12 767 57539 WDR35 WD repeat domain 35 -0,1680955 3,628023322 0,0092038 0,23452296 768 84542 KIAA184 KIAA1841 0,15617497 8,377389923 0,0092189 0,23453135 1 769 114905 C1QTNF7 C1q and tumor necrosis -0,4053495 7,037270516 0,0092403 0,23453135 factor related protein 7 770 10928 RALBP1 ralA binding protein 1 0,19118435 7,16041342 0,0092497 0,23453135 771 1428 CRYM crystallin, mu -0,3788558 2,584100941 0,0092521 0,23453135 772 10209 EIF1 eukaryotic translation -0,1831892 13,24743034 0,0092737 0,23453627 initiation factor 1 773 284185 LINC0048 long intergenic non- -0,0352317 2,278754306 0,0092763 0,23453627 2 protein coding RNA 482 774 389792 IER5L immediate early response 0,2504283 4,686552964 0,0092993 0,23466686 5-like 775 29760 BLNK B-cell linker 0,78012144 5,29503054 0,0093055 0,23466686 776 6778 STAT6 signal transducer and 0,13952761 8,389561374 0,0093505 0,23523576 activator of transcription 6, interleukin-4 induced

777 4644 MYO5A myosin VA (heavy chain 0,23961827 7,012228166 0,0093663 0,23523576 12, myoxin) 778 153222 CREBRF CREB3 regulatory factor -0,1414402 8,327805422 0,0093822 0,23523576 779 9935 MAFB v-maf avian 0,27567198 10,96637906 0,0093939 0,23523576 musculoaponeurotic fibrosarcoma oncogene homolog B 780 6535 SLC6A8 solute carrier family 6 -0,2855684 7,50599515 0,0093993 0,23523576 (neurotransmitter transporter), member 8 781 51192 CKLF chemokine-like factor 0,35392886 7,0114697 0,0094003 0,23523576 782 26469 PTPN18 protein tyrosine 0,1288019 6,454460552 0,0094192 0,23540737 phosphatase, non- receptor type 18 (brain- derived) 783 54838 WBP1L WW domain binding 0,19476594 10,39353018 0,0094413 0,23557145 protein 1-like 784 256586 LYSMD2 LysM, putative 0,31617334 7,789106386 0,0094499 0,23557145 peptidoglycan-binding, domain containing 2 785 23478 SEC11A SEC11 homolog A (S. -0,0994897 12,95576782 0,0094696 0,23576309 cerevisiae) 786 125144 LRRC75A- LRRC75A antisense RNA 1 -0,1122847 3,563856384 0,0095066 0,23584497 AS1 787 286148 DPY19L4 dpy-19-like 4 (C. elegans) -0,1240348 9,099425359 0,0095072 0,23584497

788 18 ABAT 4-aminobutyrate -0,1114335 6,63688418 0,0095094 0,23584497 aminotransferase 789 6357 CCL13 chemokine (C-C motif) 0,951533 6,14217546 0,0095212 0,23584497 ligand 13 790 8879 SGPL1 sphingosine-1-phosphate -0,0744721 5,240751694 0,0095831 0,2367847 lyase 1 791 6470 SHMT1 serine -0,4194358 8,935399174 0,0095833 0,2367847 hydroxymethyltransferase 1 (soluble) 792 832 CAPZB capping protein (actin 0,18181872 10,52338799 0,0096097 0,23713579 filament) muscle Z-line, beta 793 29087 THYN1 thymocyte nuclear protein -0,265066 9,806466981 0,0096836 0,23865748 1 794 79675 FASTKD1 FAST kinase domains 1 0,22020124 9,305386535 0,0097178 0,23919863

795 760 CA2 carbonic anhydrase II -0,8088408 5,34059614 0,0097612 0,23968871 796 85027 SMIM3 small integral membrane -0,3847419 10,90865887 0,0097726 0,23968871 protein 3 797 55068 ENOX1 ecto-NOX disulfide-thiol -0,5607629 5,127022293 0,0097805 0,23968871 exchanger 1 798 55186 SLC25A3 solute carrier family 25 -0,1775058 9,895913311 0,0097937 0,23968871 6 (pyrimidine nucleotide carrier ), member 36 799 93134 ZNF561 zinc finger protein 561 -0,1786252 5,59785725 0,009804 0,23968871 800 221749 PXDC1 PX domain containing 1 0,27243237 10,00351746 0,0098112 0,23968871 801 143098 MPP7 membrane protein, -0,2207752 4,316256127 0,0098572 0,24051164 palmitoylated 7 (MAGUK p55 subfamily member 7)

802 1028 CDKN1C cyclin-dependent kinase -0,3121089 10,94263172 0,0098946 0,24067323 inhibitor 1C (p57, Kip2)

803 23324 MAN2B2 mannosidase, alpha, class 0,19650712 9,534905173 0,0099034 0,24067323 2B, member 2 804 549 AUH AU RNA binding -0,2863958 9,597005357 0,0099099 0,24067323 protein/enoyl-CoA hydratase 805 3685 ITGAV integrin, alpha V 0,25505703 12,4795212 0,0099337 0,24067323 806 5728 PTEN phosphatase and tensin -0,2431897 9,74522369 0,009943 0,24067323 homolog 807 622 BDH1 3-hydroxybutyrate -0,3296402 2,67356709 0,0099456 0,24067323 dehydrogenase, type 1 808 23352 UBR4 ubiquitin protein ligase E3 0,15885088 8,728372987 0,0099501 0,24067323 component n-recognin 4

809 94039 ZNF101 zinc finger protein 101 0,15849798 3,339694451 0,0099665 0,24077193 810 4689 NCF4 neutrophil cytosolic factor 0,7134738 6,146288141 0,0099906 0,24105731 4, 40kDa 811 3796 KIF2A kinesin heavy chain -0,199852 6,659428916 0,0100051 0,24110851 member 2A 812 9364 RAB28 RAB28, member RAS -0,077989 8,596586751 0,0100545 0,24113826 oncogene family 813 56912 IFT46 intraflagellar transport 46 -0,1802521 7,277276423 0,0100633 0,24113826 homolog (Chlamydomonas) 814 11017 SNRNP27 small nuclear -0,1359194 9,860899091 0,0100759 0,24113826 ribonucleoprotein 27kDa (U4/U6.U5) 815 10135 NAMPT nicotinamide -0,2409354 10,17440113 0,0100848 0,24113826 phosphoribosyltransferase

816 126 ADH1C alcohol dehydrogenase 1C -0,3357077 9,495796355 0,010091 0,24113826 (class I), gamma polypeptide 817 79006 METRN meteorin, glial cell 0,08072743 3,194688428 0,0101079 0,24113826 differentiation regulator

818 65084 TMEM13 transmembrane protein -0,1937456 11,96205477 0,0101157 0,24113826 5 135 819 5494 PPM1A protein phosphatase, -0,1131323 7,955109684 0,0101181 0,24113826 Mg2+/Mn2+ dependent, 1A 820 136051 ZNF786 zinc finger protein 786 0,14987922 3,413972378 0,01012 0,24113826 821 153 ADRB1 adrenoceptor beta 1 -0,5098943 6,487947943 0,0101297 0,24113826 822 128989 TANGO2 transport and golgi 0,22755918 9,081000281 0,0101426 0,24115183 organization 2 homolog (Drosophila) 823 25896 INTS7 integrator complex subunit 0,4908602 5,168483228 0,0101787 0,24171518 7 824 285025 CCDC141 coiled-coil domain 0,02905409 2,203630049 0,0102201 0,2422912 containing 141 825 5217 PFN2 profilin 2 0,13434346 10,14615205 0,0102278 0,2422912 826 9397 NMT2 N-myristoyltransferase 2 0,35500431 10,41276119 0,0102401 0,2422912 827 79022 TMEM10 transmembrane protein -0,2471149 8,316373684 0,0102644 0,24253576 6C 106C 828 9020 MAP3K1 mitogen-activated protein 0,22245896 3,449448361 0,0102753 0,24253576 4 kinase kinase kinase 14

829 9630 GNA14 guanine nucleotide binding -0,4893189 5,952345074 0,0103431 0,24384158 protein (G protein), alpha 14 830 5775 PTPN4 protein tyrosine -0,2425543 6,574067427 0,0103739 0,24399267 phosphatase, non- receptor type 4 (megakaryocyte) 831 441027 TMEM15 transmembrane protein -0,1965207 7,452787087 0,0103744 0,24399267 0C 150C 832 594 BCKDHB branched chain keto acid -0,3139053 7,420701397 0,0104143 0,24461784 dehydrogenase E1, beta polypeptide 833 11142 PKIG protein kinase (cAMP- -0,1447065 9,693104203 0,010426 0,24461784 dependent, catalytic) inhibitor gamma 834 2690 GHR growth hormone receptor -0,2068397 13,60743962 0,0104428 0,24471824

835 7570 ZNF22 zinc finger protein 22 -0,2051722 8,830907895 0,0104646 0,24493329 836 51114 ZDHHC9 zinc finger, DHHC-type -0,2273504 6,175477737 0,0105117 0,24546949 containing 9 837 9253 NUMBL numb homolog 0,13955502 7,597108596 0,0105213 0,24546949 (Drosophila)-like 838 51138 COPS4 COP9 signalosome subunit -0,0945806 10,4573435 0,010541 0,24546949 4 839 158405 KIAA195 KIAA1958 -0,3350795 2,618078726 0,0105701 0,24546949 8 840 8495 PPFIBP2 PTPRF interacting protein, 0,28495115 7,302087036 0,0105785 0,24546949 binding protein 2 (liprin beta 2) 841 80012 PHC3 polyhomeotic homolog 3 -0,1029975 6,034338272 0,0105862 0,24546949 (Drosophila) 842 11331 PHB2 prohibitin 2 -0,147104 11,66506194 0,0105869 0,24546949 843 64431 ACTR6 ARP6 actin-related protein -0,1022188 9,457636229 0,0105941 0,24546949 6 homolog (yeast)

844 26056 RAB11FIP RAB11 family interacting 0,20235706 7,427537886 0,0106171 0,24546949 5 protein 5 (class I)

845 5654 HTRA1 HtrA serine peptidase 1 0,24061157 12,15805935 0,010629 0,24546949 846 5595 MAPK3 mitogen-activated protein 0,10315565 7,475099199 0,0106292 0,24546949 kinase 3 847 54823 SWT1 SWT1 RNA -0,149141 6,290177686 0,0106493 0,24546949 endoribonuclease homolog (S. cerevisiae) 848 1879 EBF1 early B-cell factor 1 -0,1546285 12,91029838 0,0106507 0,24546949 849 4953 ODC1 ornithine decarboxylase 1 0,18122831 9,708329234 0,0106778 0,24551596

850 23136 EPB41L3 erythrocyte membrane 0,33952166 9,465157007 0,0106807 0,24551596 protein band 4.1-like 3 851 23253 ANKRD12 ankyrin repeat domain 12 -0,1857143 8,939868777 0,0106985 0,24551596

852 11260 XPOT exportin, tRNA 0,14364284 11,93258285 0,0107318 0,24551596 853 11346 SYNPO synaptopodin 0,37615268 8,083693965 0,0107376 0,24551596 854 28526 TRDC T cell receptor delta -0,7144793 8,095764814 0,0107466 0,24551596 constant 855 8697 CDC23 cell division cycle 23 -0,0855643 8,80907304 0,0107772 0,24551596 856 23036 ZNF292 zinc finger protein 292 -0,2057692 8,257104799 0,0107805 0,24551596 857 6363 CCL19 chemokine (C-C motif) 0,93524432 7,040544096 0,0107817 0,24551596 ligand 19 858 134145 FAM173 family with sequence 0,22753326 8,753937831 0,0107891 0,24551596 B similarity 173, member B

859 154 ADRB2 adrenoceptor beta 2, -0,3966874 8,067979669 0,0108042 0,24551596 surface 860 80745 THUMPD THUMP domain containing -0,1612961 6,410824047 0,0108128 0,24551596 2 2 861 7763 ZFAND5 zinc finger, AN1-type -0,4276465 12,13273084 0,0108183 0,24551596 domain 5 862 162 AP1B1 adaptor-related protein 0,14079662 6,238303919 0,0108362 0,24551596 complex 1, beta 1 subunit

863 54881 TEX10 testis expressed 10 -0,1700543 6,819957489 0,0108457 0,24551596 864 8614 STC2 stanniocalcin 2 0,40599029 2,507016634 0,0108538 0,24551596 865 80344 DCAF11 DDB1 and CUL4 associated -0,0688013 5,329404688 0,0108747 0,24565133 factor 11 866 7481 WNT11 wingless-type MMTV -0,2683677 7,149813664 0,0108849 0,24565133 integration site family, member 11 867 5604 MAP2K1 mitogen-activated protein 0,18781089 11,43646215 0,0109312 0,24630657 kinase kinase 1 868 23204 ARL6IP1 ADP-ribosylation factor- -0,1557122 12,59712784 0,0109391 0,24630657 like 6 interacting protein 1

869 56984 PSMG2 proteasome (prosome, -0,100305 12,20521216 0,0109567 0,24641877 macropain) assembly chaperone 2 870 2770 GNAI1 guanine nucleotide binding -0,3114135 12,16877761 0,0109836 0,24673868 protein (G protein), alpha inhibiting activity polypeptide 1

871 408 ARRB1 arrestin, beta 1 -0,1668739 7,272371782 0,0110298 0,24749299 872 116328 C8orf34 chromosome 8 open -0,5003298 5,597058348 0,0110684 0,24783243 reading frame 34 873 54468 MIOS missing oocyte, meiosis -0,1225939 7,906201175 0,0110703 0,24783243 regulator, homolog (Drosophila) 874 23041 MON2 MON2 homolog (S. -0,077627 7,086694406 0,0110947 0,24786909 cerevisiae) 875 10808 HSPH1 heat shock 0,24928015 7,772271269 0,0110973 0,24786909 105kDa/110kDa protein 1

876 5898 RALA v-ral simian leukemia viral -0,1673224 10,98201777 0,0111283 0,24815204 oncogene homolog A (ras related) 877 9419 CRIPT cysteine-rich PDZ-binding -0,1454729 7,979430825 0,0111354 0,24815204 protein 878 90024 FLJ20021 uncharacterized LOC90024 -0,2120036 7,812557312 0,0112009 0,24898571

879 9737 GPRASP1 G protein-coupled -0,4773472 7,530685257 0,0112031 0,24898571 receptor associated sorting protein 1 880 3843 IPO5 importin 5 -0,1599802 9,741989645 0,0112134 0,24898571 881 3398 ID2 inhibitor of DNA binding 2, 0,38339302 9,825454544 0,0112237 0,24898571 dominant negative helix- loop-helix protein

882 8038 ADAM12 ADAM metallopeptidase 0,36433817 7,633258676 0,0112455 0,24918703 domain 12

883 89845 ABCC10 ATP-binding cassette, sub- 0,21768347 5,058046296 0,0113207 0,24974064 family C (CFTR/MRP), member 10

884 414919 C8orf82 chromosome 8 open -0,216369 7,908386283 0,0113406 0,24974064 reading frame 82 885 6733 SRPK2 SRSF protein kinase 2 -0,0978696 7,361749268 0,0113557 0,24974064 886 5002 SLC22A1 solute carrier family 22, 0,25880675 6,320667001 0,0113646 0,24974064 8 member 18 887 51019 CCDC53 coiled-coil domain 0,16789825 10,1879486 0,0113658 0,24974064 containing 53 888 7818 DAP3 death associated protein 3 -0,089652 11,11235235 0,0113666 0,24974064

889 5947 RBP1 retinol binding protein 1, -0,663602 5,70710754 0,0113686 0,24974064 cellular 890 1439 CSF2RB colony stimulating factor 2 0,82542584 7,000445715 0,0113841 0,24974064 receptor, beta, low-affinity (granulocyte-macrophage)

891 22836 RHOBTB3 Rho-related BTB domain -0,2559515 12,14816079 0,0113963 0,24974064 containing 3 892 1E+08 LOC1005 uncharacterized -0,1806648 11,68930082 0,0113983 0,24974064 07217 LOC100507217 893 57085 AGTRAP angiotensin II receptor- 0,36300294 5,662033144 0,0114119 0,2497592 associated protein 894 51454 GULP1 GULP, engulfment adaptor -0,254856 8,579236495 0,0114405 0,25010492 PTB domain containing 1

895 51222 ZNF219 zinc finger protein 219 0,09935531 2,534929585 0,011461 0,25027293 896 7549 ZNF2 zinc finger protein 2 -0,1609918 4,525545518 0,0115303 0,25106264 897 51727 CMPK1 cytidine monophosphate 0,06590898 10,27618338 0,0115325 0,25106264 (UMP-CMP) kinase 1, cytosolic

898 2822 GPLD1 glycosylphosphatidylinosit 0,39730292 4,466801568 0,0115357 0,25106264 ol specific phospholipase D1 899 414 ARSD arylsulfatase D 0,07514355 5,781148105 0,0115693 0,25126613 900 4149 MAX MYC associated factor X 0,04635208 5,729210621 0,0115829 0,25126613 901 6138 RPL15 ribosomal protein L15 -0,1009209 13,81914766 0,0115879 0,25126613 902 1155 TBCB tubulin folding cofactor B 0,14986452 9,531244868 0,0115965 0,25126613

903 64798 DEPTOR DEP domain containing 0,34216228 7,317859937 0,0116367 0,25185818 MTOR-interacting protein

904 28955 DEXI Dexi homolog (mouse) 0,17105372 8,058023421 0,0116769 0,2524476 905 157 ADRBK2 adrenergic, beta, receptor -0,2392011 9,577571577 0,0117225 0,25315374 kinase 2 906 11101 ATE1 arginyltransferase 1 -0,1025713 7,706691453 0,0117476 0,25319157 907 221294 NT5DC1 5'-nucleotidase domain -0,1663306 9,439114148 0,0117533 0,25319157 containing 1 908 5793 PTPRG protein tyrosine -0,3350335 7,909698088 0,0117631 0,25319157 phosphatase, receptor type, G 909 57698 KIAA159 KIAA1598 0,44690896 8,922845686 0,011787 0,25322669 8 910 3952 LEP leptin 0,33206938 14,28673597 0,0117918 0,25322669 911 49855 SCAPER S-phase cyclin A- -0,2498233 5,909614544 0,0118036 0,25322669 associated protein in the ER 912 55364 IMPACT impact RWD domain -0,1449339 8,364098876 0,0118191 0,25328102 protein 913 6916 TBXAS1 thromboxane A synthase 1 0,24505208 4,996912087 0,0118536 0,25374138 (platelet) 914 9194 SLC16A7 solute carrier family 16 -0,3778492 10,34985296 0,0119249 0,25489839 (monocarboxylate transporter), member 7 915 26054 SENP6 SUMO1/sentrin specific -0,0933699 9,028500067 0,0119388 0,25489839 peptidase 6 916 285704 RGMB repulsive guidance -0,2879776 5,838154331 0,0119467 0,25489839 molecule family member b 917 682 BSG basigin (Ok blood group) -0,2772927 7,729336537 0,0120388 0,25658284

918 59342 SCPEP1 serine carboxypeptidase 1 0,25307615 9,392193169 0,0120623 0,25671852

919 171586 ABHD3 abhydrolase domain -0,1377902 9,631019706 0,0120714 0,25671852 containing 3 920 2071 ERCC3 excision repair cross- -0,14192 6,600176 0,0120885 0,25680083 complementation group 3

921 219927 MRPL21 mitochondrial ribosomal -0,1345261 8,767845155 0,012139 0,25707112 protein L21 922 2802 GOLGA3 golgin A3 0,17420113 7,21261857 0,0121425 0,25707112 923 51366 UBR5 ubiquitin protein ligase E3 -0,1427658 9,260353724 0,0121457 0,25707112 component n-recognin 5

924 5985 RFC5 replication factor C -0,082737 5,534247446 0,0121538 0,25707112 (activator 1) 5, 36.5kDa 925 404201 WDFY3- WDFY3 antisense RNA 2 -0,3137975 5,022619318 0,0121884 0,25736783 AS2 926 84987 COX14 cytochrome c oxidase -0,2714162 10,84469135 0,0122044 0,25736783 assembly homolog 14 (S. cerevisiae) 927 55638 SYBU syntabulin (syntaxin- -0,3116339 8,864934624 0,0122188 0,25736783 interacting) 928 53340 SPA17 sperm autoantigenic 0,50822675 4,768388251 0,0122205 0,25736783 protein 17 929 10048 RANBP9 RAN binding protein 9 -0,1855107 8,962023154 0,012239 0,25748055 930 1070 CETN3 centrin, EF-hand protein, 3 -0,1303949 10,13887374 0,012254 0,25751935

931 5432 POLR2C polymerase (RNA) II (DNA -0,1089684 8,628129685 0,0122758 0,25769879 directed) polypeptide C, 33kDa 932 57570 TRMT5 tRNA methyltransferase 5 -0,1607987 6,936509141 0,01231 0,25814014

933 4863 NPAT nuclear protein, ataxia- -0,1109208 6,923759026 0,0123603 0,2585436 telangiectasia locus 934 9070 ASH2L ash2 (absent, small, or -0,1574209 8,49928632 0,012375 0,2585436 homeotic)-like (Drosophila) 935 158800 RHOXF1 Rhox homeobox family, 0,5110216 6,17664043 0,0123797 0,2585436 member 1 936 2730 GCLM glutamate-cysteine ligase, 0,30042188 8,951774795 0,0123822 0,2585436 modifier subunit

937 10131 TRAP1 TNF receptor-associated -0,1782745 7,782909979 0,0124541 0,2597673 protein 1 938 54956 PARP16 poly (ADP-ribose) -0,2037636 6,12542373 0,0125538 0,26156779 polymerase family, member 16 939 55183 RIF1 RAP1 interacting factor -0,0845558 7,168386736 0,0125846 0,2619322 homolog (yeast) 940 84896 ATAD1 ATPase family, AAA -0,1501641 8,717917679 0,0126138 0,26220785 domain containing 1 941 9655 SOCS5 suppressor of cytokine 0,129383 8,920912003 0,0126247 0,26220785 signaling 5 942 8720 MBTPS1 membrane-bound 0,1233256 7,84585912 0,0126407 0,26226141 transcription factor peptidase, site 1 943 11329 STK38 serine/threonine kinase 38 0,11079641 7,720146603 0,0126722 0,26239057

944 78988 MRPL57 mitochondrial ribosomal -0,0905458 9,39034988 0,0126799 0,26239057 protein L57 945 712 C1QA complement component 0,45251673 8,381414113 0,0126886 0,26239057 1, q subcomponent, A chain 946 57593 EBF4 early B-cell factor 4 -0,0580539 2,293609114 0,0127124 0,26239057 947 51388 NIP7 NIP7, nucleolar pre-rRNA 0,13533442 7,696427388 0,0127216 0,26239057 processing protein

948 6767 ST13 suppression of -0,1494927 12,10437285 0,0127275 0,26239057 tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein)

949 55339 WDR33 WD repeat domain 33 -0,1003717 6,45949856 0,0127604 0,26279186 950 81037 CLPTM1L CLPTM1-like 0,19558512 10,44491063 0,0127924 0,26310988

951 1E+08 LOC1005 uncharacterized 0,48412833 3,481890063 0,0128053 0,26310988 06388 LOC100506388 952 11019 LIAS lipoic acid synthetase -0,3343115 7,690467883 0,0128165 0,26310988 953 6492 SIM1 single-minded family bHLH -0,6109782 3,939944706 0,0128458 0,26310988 transcription factor 1

954 122961 ISCA2 iron-sulfur cluster -0,1609461 8,399098131 0,0128461 0,26310988 assembly 2 955 79656 BEND5 BEN domain containing 5 -0,356473 5,482676388 0,0128566 0,26310988

956 6146 RPL22 ribosomal protein L22 -0,1439173 11,88637711 0,0128851 0,26319274 957 65057 ACD adrenocortical dysplasia 0,09749021 6,791698654 0,0128876 0,26319274 homolog (mouse)

958 26097 CHTOP chromatin target of 0,07569631 8,471537602 0,0129129 0,26343408 PRMT1 959 7220 TRPC1 transient receptor -0,1776561 6,764898124 0,01297 0,26432193 potential cation channel, subfamily C, member 1 960 79607 FAM118 family with sequence 0,23005494 6,252125299 0,0130077 0,26481502 B similarity 118, member B

961 10735 STAG2 stromal antigen 2 -0,2059784 10,10937288 0,0130387 0,26516938 962 119504 ANAPC16 anaphase promoting -0,1165892 11,15573875 0,0130721 0,26557217 complex subunit 16 963 221472 FGD2 FYVE, RhoGEF and PH 0,15958009 6,404466952 0,0131268 0,26615876 domain containing 2 964 80723 SLC35G2 solute carrier family 35, -0,3564001 9,027402225 0,0131282 0,26615876 member G2 965 65008 MRPL1 mitochondrial ribosomal -0,1346523 9,246295906 0,0131834 0,26693733 protein L1 966 22930 RAB3GAP RAB3 GTPase activating -0,084953 9,154876421 0,0131939 0,26693733 1 protein subunit 1 (catalytic) 967 11031 RAB31 RAB31, member RAS 0,36833499 9,849620734 0,0132625 0,26804787 oncogene family 968 283267 LINC0029 long intergenic non- 0,19635684 7,414106025 0,0133002 0,26835732 4 protein coding RNA 294 969 29916 SNX11 sorting nexin 11 0,15980052 7,016718318 0,0133053 0,26835732 970 5095 PCCA propionyl CoA carboxylase, -0,2379235 9,27021869 0,013428 0,27055323 alpha polypeptide

971 87 ACTN1 actinin, alpha 1 0,23347062 10,30434025 0,013455 0,27072084 972 11157 LSM6 LSM6 homolog, U6 small -0,2087106 10,51537781 0,013464 0,27072084 nuclear RNA associated (S. cerevisiae)

973 78991 PCYOX1L prenylcysteine oxidase 1 0,27992787 6,486476883 0,0134831 0,2708254 like 974 29883 CNOT7 CCR4-NOT transcription -0,079278 7,644682115 0,0134991 0,27086907 complex, subunit 7 975 375387 NRROS negative regulator of 0,28523307 5,376255839 0,0135224 0,27105784 reactive oxygen species

976 51218 GLRX5 glutaredoxin 5 0,10369747 10,65370397 0,0135665 0,2712265 977 54904 WHSC1L1 Wolf-Hirschhorn syndrome -0,1263696 6,759009185 0,0135709 0,2712265 candidate 1-like 1

978 5859 QARS glutaminyl-tRNA -0,1003706 10,3315756 0,0135724 0,2712265 synthetase 979 1737 DLAT dihydrolipoamide S- -0,3473853 9,051445478 0,0136114 0,27172784 acetyltransferase 980 56977 STOX2 storkhead box 2 0,2589448 5,678402439 0,0136725 0,27266911 981 148979 GLIS1 GLIS family zinc finger 1 -0,5426409 2,684973514 0,0137027 0,27299271 982 79828 METTL8 methyltransferase like 8 0,14157773 5,644864323 0,0137453 0,27356294

983 3995 FADS3 fatty acid desaturase 3 0,32494882 10,29949545 0,0137842 0,27405827 984 5551 PRF1 perforin 1 (pore forming 0,23511101 2,993099749 0,0138555 0,27457241 protein) 985 9578 CDC42BP CDC42 binding protein 0,15339763 8,393687175 0,0138726 0,27457241 B kinase beta (DMPK-like)

986 84791 LINC0046 long intergenic non- -0,2714181 7,739825167 0,0138742 0,27457241 7 protein coding RNA 467 987 22818 COPZ1 coatomer protein -0,1114869 9,103916015 0,0138924 0,27457241 complex, subunit zeta 1 988 55337 C19orf66 chromosome 19 open 0,18683428 6,475409113 0,0138931 0,27457241 reading frame 66 989 1175 AP2S1 adaptor-related protein 0,14419109 9,657116438 0,0139024 0,27457241 complex 2, sigma 1 subunit

990 64393 ZMAT3 zinc finger, matrin-type 3 0,19459486 7,28721969 0,0139084 0,27457241

991 22846 VASH1 vasohibin 1 0,28547994 5,139737773 0,0139521 0,27515657 992 10513 APPBP2 amyloid beta precursor -0,1360629 9,34207166 0,0140047 0,27591478 protein (cytoplasmic tail) binding protein 2 993 6581 SLC22A3 solute carrier family 22 -0,1999931 7,970465222 0,0140373 0,27627807 (organic cation transporter), member 3 994 64940 STAG3L4 stromal antigen 3-like 4 -0,2892544 5,685530158 0,0140801 0,27669823 (pseudogene) 995 55781 RIOK2 RIO kinase 2 -0,1516208 7,773064319 0,0140869 0,27669823 996 1E+08 LOC1019 uncharacterized 0,12216919 3,35721923 0,0141193 0,27705565 28403 LOC101928403 997 6404 SELPLG selectin P ligand 0,21698808 4,70531226 0,0141958 0,27816417 998 8455 ATRN attractin 0,18608063 7,535765038 0,014218 0,27816417 999 161823 ADAL adenosine deaminase-like -0,1696015 5,272262789 0,0142185 0,27816417

1000 10614 HEXIM1 hexamethylene bis- 0,48495795 8,367385725 0,0143063 0,27934086 acetamide inducible 1 1001 645212 EIF3J-AS1 EIF3J antisense RNA 1 -0,216337 6,1003181 0,0143072 0,27934086 (head to head) 1002 84138 SLC7A6O solute carrier family 7, -0,2153811 6,589882539 0,0143425 0,27945948 S member 6 opposite strand

1003 1E+08 IQCH-AS1 IQCH antisense RNA 1 0,3071887 4,618613337 0,0143437 0,27945948

1004 80216 ALPK1 alpha-kinase 1 0,18424702 4,488087932 0,0143562 0,27945948 1005 23370 ARHGEF1 Rho/Rac guanine 0,15854361 7,543825109 0,0143812 0,27966743 8 nucleotide exchange factor (GEF) 18 1006 200081 TXLNA taxilin alpha 0,16554652 7,108595378 0,0144354 0,27970765 1007 57188 ADAMTS ADAMTS-like 3 -0,2838795 4,910374496 0,0144362 0,27970765 L3 1008 126068 ZNF441 zinc finger protein 441 -0,1564259 4,850759475 0,0144376 0,27970765 1009 4066 LYL1 lymphoblastic leukemia 0,32328441 7,210507301 0,0144427 0,27970765 associated hematopoiesis regulator 1

1010 1829 DSG2 desmoglein 2 -0,4217131 8,279906817 0,0144548 0,27970765 1011 23507 LRRC8B leucine rich repeat -0,2558255 5,537147513 0,0146038 0,28231059 containing 8 family, member B 1012 9536 PTGES prostaglandin E synthase -0,33643 6,377556403 0,0146279 0,28247485

1013 10714 POLD3 polymerase (DNA- -0,16803 6,695917088 0,0146412 0,28247485 directed), delta 3, accessory subunit 1014 10399 GNB2L1 guanine nucleotide binding -0,0898288 14,54176069 0,0146804 0,28293145 protein (G protein), beta polypeptide 2-like 1

1015 2017 CTTN cortactin 0,12333488 7,251342599 0,014694 0,28293145 1016 6605 SMARCE SWI/SNF related, matrix -0,0909098 9,290974391 0,0147083 0,28293145 1 associated, actin dependent regulator of chromatin, subfamily e, member 1 1017 64754 SMYD3 SET and MYND domain -0,1310849 6,505584947 0,0147984 0,2843854 containing 3 1018 3155 HMGCL 3-hydroxymethyl-3- -0,1215126 8,792696694 0,0148188 0,28449787 methylglutaryl-CoA lyase

1019 9748 SLK STE20-like kinase -0,1191643 10,36487582 0,0148427 0,284664 1020 117581 TWIST2 twist family bHLH 0,25650165 4,011491815 0,0148566 0,284664 transcription factor 2 1021 92806 CENPBD1 CENPB DNA-binding 0,15859041 5,952473229 0,0148748 0,28473358 domains containing 1 1022 192286 HIGD2A HIG1 hypoxia inducible -0,1702 10,29811846 0,0148966 0,28487137 domain family, member 2A 1023 84417 C2orf40 chromosome 2 open -0,3460956 11,05906025 0,0149355 0,28533696 reading frame 40 1024 713 C1QB complement component 0,64854623 8,6870722 0,0149554 0,28539619 1, q subcomponent, B chain 1025 79071 ELOVL6 ELOVL fatty acid elongase -1,2235364 7,378677188 0,0149678 0,28539619 6 1026 55669 MFN1 mitofusin 1 -0,1124362 8,480516249 0,0150053 0,2854269 1027 346007 EYS eyes shut homolog -0,5338965 3,45247246 0,0150107 0,2854269 (Drosophila) 1028 55191 NADSYN1 NAD synthetase 1 0,14644994 6,800859229 0,0150132 0,2854269 1029 79567 FAM65A family with sequence 0,05362778 5,87211564 0,0150391 0,28564004 similarity 65, member A

1030 6774 STAT3 signal transducer and 0,22311738 9,717485787 0,0150558 0,2856806 activator of transcription 3 (acute-phase response factor) 1031 51660 MPC1 mitochondrial pyruvate -0,1932073 10,76147424 0,0150859 0,28579004 carrier 1 1032 4700 NDUFA6 NADH dehydrogenase -0,1701724 9,869783228 0,0150908 0,28579004 (ubiquinone) 1 alpha subcomplex, 6, 14kDa 1033 11030 RBPMS RNA binding protein with -0,2799739 8,904788353 0,0151192 0,28605073 multiple splicing 1034 7430 EZR ezrin 0,18415753 4,683411628 0,0151397 0,2861062 1035 6480 ST6GAL1 ST6 beta-galactosamide 0,15663459 4,940848608 0,0151514 0,2861062 alpha-2,6-sialyltranferase 1 1036 220 ALDH1A3 aldehyde dehydrogenase 1 0,942171 8,314081058 0,0152081 0,28678787 family, member A3

1037 168667 BMPER BMP binding endothelial -0,0880594 2,289838937 0,0152169 0,28678787 regulator 1038 80339 PNPLA3 patatin-like phospholipase -1,0088054 6,818797142 0,0152391 0,2869299 domain containing 3

1039 727 C5 complement component 5 -0,3827917 5,980222151 0,0152829 0,28720534

1040 78996 C7orf49 chromosome 7 open 0,14853824 7,076723126 0,0152853 0,28720534 reading frame 49 1041 55304 SPTLC3 serine -0,2483532 3,687524267 0,0152978 0,28720534 palmitoyltransferase, long chain base subunit 3

1042 211 ALAS1 aminolevulinate, delta-, 0,26048751 9,042189597 0,0153268 0,2874733 synthase 1 1043 7332 UBE2L3 ubiquitin-conjugating 0,13644865 7,948434062 0,015348 0,28759424 enzyme E2L 3 1044 161582 DYX1C1 dyslexia susceptibility 1 0,28014482 2,589208162 0,0154244 0,28846338 candidate 1 1045 23029 RBM34 RNA binding motif protein -0,0310604 7,446144623 0,015443 0,28846338 34 1046 131616 TMEM42 transmembrane protein 42 -0,1784603 8,284126074 0,0154471 0,28846338

1047 84803 AGPAT9 1-acylglycerol-3-phosphate -1,0910092 6,811228157 0,0154534 0,28846338 O-acyltransferase 9

1048 23259 DDHD2 DDHD domain containing 2 -0,1326919 10,37961481 0,015488 0,28883259

1049 1123 CHN1 chimerin 1 0,33196026 6,738710039 0,0155118 0,28900081 1050 51090 PLLP plasmolipin 0,37273399 3,036356763 0,0155669 0,28932061 1051 64398 MPP5 membrane protein, 0,09809051 7,352445546 0,0156084 0,28932061 palmitoylated 5 (MAGUK p55 subfamily member 5)

1052 339983 NAT8L N-acetyltransferase 8-like -0,2745841 9,39850654 0,0156257 0,28932061 (GCN5-related, putative)

1053 4615 MYD88 myeloid differentiation 0,32471515 9,015151394 0,0156444 0,28932061 primary response 88 1054 9360 PPIG peptidylprolyl isomerase G -0,0959258 9,642572722 0,0156499 0,28932061 (cyclophilin G)

1055 55320 MIS18BP MIS18 binding protein 1 -0,324965 7,44104517 0,0156565 0,28932061 1 1056 5269 SERPINB serpin peptidase inhibitor, -0,1628053 9,082351104 0,0156606 0,28932061 6 clade B (ovalbumin), member 6 1057 23536 ADAT1 adenosine deaminase, 0,40130606 6,561710492 0,0156665 0,28932061 tRNA-specific 1 1058 3064 HTT huntingtin 0,12877472 4,455559231 0,0156836 0,28932061 1059 813 CALU calumenin 0,33462663 8,276362117 0,0156841 0,28932061 1060 1845 DUSP3 dual specificity 0,09813472 6,393438364 0,0156994 0,28932061 phosphatase 3 1061 80055 PGAP1 post-GPI attachment to -0,1589045 4,473936806 0,0157068 0,28932061 proteins 1 1062 128240 APOA1BP apolipoprotein A-I binding 0,13002494 9,124419706 0,0157214 0,28932061 protein 1063 91851 CHRDL1 chordin-like 1 0,13866431 13,80612461 0,0159048 0,29226502 1064 25829 TMEM18 transmembrane protein 0,1199601 9,337241298 0,0159138 0,29226502 4B 184B 1065 23473 CAPN7 calpain 7 -0,1688815 8,943823316 0,0159373 0,29226502 1066 122525 C14orf28 chromosome 14 open -0,1378922 7,290075178 0,0159412 0,29226502 reading frame 28 1067 349136 WDR86 WD repeat domain 86 -0,5980803 5,29311023 0,0159675 0,29228036 1068 51101 ZC2HC1A zinc finger, C2HC-type -0,3203503 7,436012941 0,0159719 0,29228036 containing 1A 1069 90768 MGC458 uncharacterized LOC90768 -0,2423211 2,968830694 0,0160185 0,29285873 00 1070 51696 HECA headcase homolog -0,1671341 10,23551955 0,0160703 0,29353017 (Drosophila) 1071 9653 HS2ST1 heparan sulfate 2-O- -0,1517883 7,005374015 0,0160962 0,29372933 sulfotransferase 1 1072 1E+08 MIR3682 microRNA 3682 0,62826449 4,862297571 0,0161158 0,29381267

1073 154791 C7orf55 chromosome 7 open -0,2594812 9,017046219 0,0161363 0,29391261 reading frame 55 1074 283209 PGM2L1 phosphoglucomutase 2- 0,18869498 4,780543747 0,016235 0,29543401 like 1 1075 29072 SETD2 SET domain containing 2 -0,1245432 7,942746895 0,0162738 0,29560027

1076 2202 EFEMP1 EGF containing fibulin-like 0,25967868 12,15177523 0,0162978 0,29560027 extracellular matrix protein 1 1077 55002 TMCO3 transmembrane and coiled- 0,2618867 7,903331041 0,0163216 0,29560027 coil domains 3 1078 79158 GNPTAB N-acetylglucosamine-1- 0,17387089 8,725338403 0,0163235 0,29560027 phosphate transferase, alpha and beta subunits

1079 845 CASQ2 calsequestrin 2 (cardiac -0,7312574 6,148435536 0,0163323 0,29560027 muscle) 1080 7507 XPA xeroderma pigmentosum, -0,1137611 8,577501893 0,0163348 0,29560027 complementation group A

1081 9180 OSMR oncostatin M receptor 0,26765862 5,19627777 0,0163557 0,29570452 1082 84975 MFSD5 major facilitator 0,23077577 7,080635409 0,0163747 0,29577319 superfamily domain containing 5 1083 282969 FUOM fucose mutarotase -0,2128375 6,719553975 0,0164125 0,29607538 1084 9679 FAM53B family with sequence 0,17188318 6,287714693 0,0164261 0,29607538 similarity 53, member B 1085 7108 TM7SF2 transmembrane 7 -0,5253163 9,107714782 0,0164368 0,29607538 superfamily member 2 1086 55654 TMEM12 transmembrane protein 0,13398861 7,932437686 0,0164672 0,296134 7 127 1087 51085 MLXIPL MLX interacting protein- -0,3399987 7,67557648 0,0164704 0,296134 like 1088 27348 TOR1B torsin family 1, member B 0,1392704 7,700860897 0,0164989 0,29637285 (torsin B) 1089 339230 CCDC137 coiled-coil domain 0,21171196 6,338512652 0,0165588 0,29717603 containing 137 1090 60496 AASDHPP aminoadipate- -0,1302952 9,278650372 0,0166262 0,29811156 T semialdehyde dehydrogenase- phosphopantetheinyl transferase 1091 51082 POLR1D polymerase (RNA) I -0,1067276 9,434071915 0,0166459 0,29818606 polypeptide D, 16kDa 1092 203 AK1 adenylate kinase 1 0,22569742 6,438238382 0,0166613 0,29818606 1093 51496 CTDSPL2 CTD (carboxy-terminal -0,163262 7,000562553 0,0166777 0,29818606 domain, RNA polymerase II, polypeptide A) small phosphatase like 2

1094 84717 HDGFRP2 hepatoma-derived growth -0,1867585 7,065191877 0,0167008 0,29818606 factor-related protein 2 1095 1E+08 LINC0100 long intergenic non- -0,6208051 4,472485453 0,0167148 0,29818606 6 protein coding RNA 1006

1096 79415 C17orf62 chromosome 17 open 0,12445847 7,930115376 0,0167285 0,29818606 reading frame 62 1097 7444 VRK2 vaccinia related kinase 2 -0,1174698 8,084762125 0,0167535 0,29818606

1098 2246 FGF1 fibroblast growth factor 1 0,46582469 4,357747593 0,0167659 0,29818606 (acidic) 1099 55756 INTS9 integrator complex subunit 0,17404484 5,654873064 0,0167676 0,29818606 9 1100 664 BNIP3 BCL2/adenovirus E1B -0,2530295 12,20508125 0,0168034 0,29854983 19kDa interacting protein 3 1101 54496 PRMT7 protein arginine -0,1294116 5,279521466 0,0168203 0,29857895 methyltransferase 7 1102 55837 EAPP E2F-associated -0,1384635 10,15170833 0,016861 0,29874279 phosphoprotein 1103 1E+08 LOC1001 uncharacterized 0,25741698 2,849554647 0,0168674 0,29874279 30938 LOC100130938 1104 81858 SHARPIN SHANK-associated RH -0,0779134 7,089971742 0,0168754 0,29874279 domain interactor 1105 7411 VBP1 von Hippel-Lindau binding -0,0933785 10,59610517 0,0169061 0,29901543 protein 1 1106 11185 INMT indolethylamine N- 0,46293195 6,777526942 0,0169421 0,29912061 methyltransferase 1107 1393 CRHBP corticotropin releasing -1,3546578 7,064866587 0,0169426 0,29912061 hormone binding protein

1108 152078 C3orf55 chromosome 3 open -0,3339533 7,201502671 0,0169794 0,29949881 reading frame 55 1109 7403 KDM6A lysine (K)-specific -0,1293838 7,430248822 0,0170716 0,30085502 demethylase 6A 1110 57720 GPR107 G protein-coupled 0,15994728 6,238605199 0,0171442 0,30186115 receptor 107 1111 63908 NAPB N-ethylmaleimide- 0,27117323 6,506878088 0,0171828 0,30226797 sensitive factor attachment protein, beta

1112 55616 ASAP3 ArfGAP with SH3 domain, 0,11269875 6,335795203 0,0172957 0,30314229 ankyrin repeat and PH domain 3 1113 58480 RHOU ras homolog family -0,3006866 7,648441419 0,0173108 0,30314229 member U 1114 494513 DFNB59 deafness, autosomal -0,3637697 6,229841257 0,0173299 0,30314229 recessive 59 1115 54764 ZRANB1 zinc finger, RAN-binding -0,146606 8,034518724 0,0173303 0,30314229 domain containing 1

1116 9632 SEC24C SEC24 family member C 0,12621935 8,538675601 0,0173344 0,30314229 1117 27151 CPAMD8 C3 and PZP-like, alpha-2- -0,512192 3,968758971 0,0173397 0,30314229 macroglobulin domain containing 8 1118 57149 LYRM1 LYR motif containing 1 -0,1208638 11,11928569 0,017341 0,30314229 1119 6880 TAF9 TAF9 RNA polymerase II, -0,1001273 10,08969732 0,017371 0,30316069 TATA box binding protein (TBP)-associated factor, 32kDa

1120 4666 NACA nascent polypeptide- -0,1055825 14,04753505 0,0173731 0,30316069 associated complex alpha subunit 1121 9912 ARHGAP Rho GTPase activating -0,4646859 4,261448526 0,0174271 0,30359262 44 protein 44 1122 4798 NFRKB nuclear factor related to -0,0797167 3,793563826 0,0174433 0,30359262 kappaB binding protein

1123 10288 LILRB2 leukocyte immunoglobulin- 0,77353085 6,051125903 0,0174445 0,30359262 like receptor, subfamily B (with TM and ITIM domains), member 2

1124 7737 RNF113A ring finger protein 113A -0,1800414 7,145812008 0,0174692 0,30375281

1125 10211 FLOT1 flotillin 1 0,11878556 8,598215319 0,0175261 0,30447149 1126 285636 C5orf51 chromosome 5 open -0,1220264 9,736736722 0,0175688 0,30493807 reading frame 51 1127 84545 MRPL43 mitochondrial ribosomal -0,1371579 8,49855688 0,0175842 0,30493807 protein L43 1128 1841 DTYMK deoxythymidylate kinase 0,15600016 7,09468416 0,017619 0,30503139 (thymidylate kinase)

1129 3080 CFHR2 complement factor H- 0,1587263 5,42708525 0,0176208 0,30503139 related 2 1130 219749 ZNF25 zinc finger protein 25 -0,1103798 9,029045158 0,0176732 0,30566897 1131 4054 LTBP3 latent transforming 0,24946523 8,455116636 0,0176967 0,30571167 growth factor beta binding protein 3 1132 9329 GTF3C4 general transcription -0,4743116 3,611203625 0,0177253 0,30571167 factor IIIC, polypeptide 4, 90kDa 1133 55892 MYNN myoneurin -0,1222823 6,525952889 0,0177305 0,30571167 1134 7089 TLE2 transducin-like enhancer 0,32039935 7,231854912 0,0177688 0,30571167 of split 2 1135 9600 PITPNM1 phosphatidylinositol 0,14203578 4,106388563 0,01777 0,30571167 transfer protein, membrane-associated 1

1136 79026 AHNAK AHNAK nucleoprotein 0,16982885 10,42359791 0,0177804 0,30571167 1137 55090 MED9 mediator complex subunit -0,0455251 2,553085129 0,0177852 0,30571167 9 1138 10421 CD2BP2 CD2 (cytoplasmic tail) 0,11570289 6,863324123 0,0178301 0,30586618 binding protein 2 1139 114799 ESCO1 establishment of sister -0,1703135 5,856502847 0,0178659 0,30586618 chromatid cohesion N- acetyltransferase 1 1140 51155 HN1 hematological and 0,43142865 6,712495234 0,0178939 0,30586618 neurological expressed 1

1141 9731 CEP104 centrosomal protein 0,13964928 6,346176754 0,0178946 0,30586618 104kDa 1142 157506 RDH10 retinol dehydrogenase 10 -0,2849883 8,56077409 0,0179302 0,30586618 (all-trans) 1143 124808 CCDC43 coiled-coil domain 0,12541539 8,252463745 0,0179398 0,30586618 containing 43 1144 8459 TPST2 tyrosylprotein 0,31039237 10,32141469 0,0179405 0,30586618 sulfotransferase 2 1145 54928 IMPAD1 inositol monophosphatase 0,19500822 9,348374417 0,017947 0,30586618 domain containing 1

1146 1E+08 LINC0096 long intergenic non- 0,36168 4,246567237 0,0179496 0,30586618 3 protein coding RNA 963 1147 57092 PCNP PEST proteolytic signal -0,092999 11,14791267 0,0179507 0,30586618 containing nuclear protein

1148 6799 SULT1A2 sulfotransferase family, 0,59401443 7,304271398 0,0179758 0,30602716 cytosolic, 1A, phenol- preferring, member 2

1149 26011 TENM4 teneurin transmembrane 0,57808592 6,963750125 0,0180164 0,3064506 protein 4

1150 27075 TSPAN13 tetraspanin 13 -0,3126477 12,37225002 0,0180559 0,30670532

1151 57003 CCDC47 coiled-coil domain 0,16603615 9,266829887 0,0180628 0,30670532 containing 47 1152 22882 ZHX2 zinc fingers and -0,132034 3,81329681 0,0180805 0,30670532 homeoboxes 2 1153 79699 ZYG11B zyg-11 family member B, -0,0960041 9,653028662 0,0180941 0,30670532 cell cycle regulator 1154 80222 TARS2 threonyl-tRNA synthetase -0,1391463 5,37490653 0,0181246 0,3069561 2, mitochondrial (putative)

1155 6100 RP9 retinitis pigmentosa 9 -0,1881392 8,338477087 0,0181471 0,30702188 (autosomal dominant) 1156 7936 NELFE negative elongation factor -0,1257734 9,862984995 0,0181599 0,30702188 complex member E 1157 57546 PDP2 pyruvate dehyrogenase -0,3522409 7,14707531 0,0181842 0,30703451 phosphatase catalytic subunit 2 1158 54893 MTMR10 myotubularin related -0,0843763 9,596370987 0,0181921 0,30703451 protein 10 1159 5318 PKP2 plakophilin 2 -0,4804294 2,731347211 0,0182418 0,30744369 1160 593 BCKDHA branched chain keto acid -0,2633383 7,209823838 0,0182622 0,30744369 dehydrogenase E1, alpha polypeptide 1161 3178 HNRNPA heterogeneous nuclear -0,1815303 7,583100872 0,0182635 0,30744369 1 ribonucleoprotein A1 1162 93653 ST7-AS1 ST7 antisense RNA 1 -0,1760714 2,540487517 0,0182914 0,30757604 1163 9325 TRIP4 thyroid hormone receptor -0,1494449 8,897915427 0,0183058 0,30757604 interactor 4 1164 1303 COL12A1 collagen, type XII, alpha 1 0,3571089 7,053157803 0,0183297 0,30757604

1165 84967 LSM10 LSM10, U7 small nuclear 0,23806362 7,861024521 0,0183343 0,30757604 RNA associated 1166 7555 CNBP CCHC-type zinc finger, -0,0845783 10,00439871 0,0183644 0,30781662 nucleic acid binding protein 1167 30836 DNTTIP2 deoxynucleotidyltransferas -0,091022 10,22628684 0,0184367 0,30820718 e, terminal, interacting protein 2 1168 4783 NFIL3 nuclear factor, interleukin -0,4997305 8,216835302 0,0184542 0,30820718 3 regulated 1169 8934 RAB7L1 RAB7, member RAS 0,15511449 8,163275473 0,0184556 0,30820718 oncogene family-like 1 1170 376940 ZC3H6 zinc finger CCCH-type -0,2196141 6,201475594 0,0184756 0,30820718 containing 6 1171 116984 ARAP2 ArfGAP with RhoGAP 0,6471176 4,11084184 0,0184796 0,30820718 domain, ankyrin repeat and PH domain 2 1172 2180 ACSL1 acyl-CoA synthetase long- -0,2395085 14,17250965 0,0184823 0,30820718 chain family member 1

1173 5873 RAB27A RAB27A, member RAS 0,16518905 6,947094458 0,0185192 0,30853701 oncogene family 1174 153830 RNF145 ring finger protein 145 0,16156725 8,787355787 0,0185423 0,30853701 1175 139221 MUM1L1 melanoma associated -0,4634502 5,82261629 0,0185697 0,30853701 antigen (mutated) 1-like 1

1176 84281 C2orf88 chromosome 2 open 0,30759203 3,982649809 0,0186043 0,30853701 reading frame 88 1177 4891 SLC11A2 solute carrier family 11 0,18954451 6,727575856 0,0186065 0,30853701 (proton-coupled divalent metal ion transporter), member 2 1178 27247 NFU1 NFU1 iron-sulfur cluster -0,1744573 11,64761385 0,0186235 0,30853701 scaffold homolog (S. cerevisiae) 1179 55048 VPS37C vacuolar protein sorting 37 0,04979041 6,637073569 0,0186237 0,30853701 homolog C (S. cerevisiae)

1180 2220 FCN2 ficolin (collagen/fibrinogen -0,9437192 3,601632884 0,0186284 0,30853701 domain containing lectin) 2

1181 7178 TPT1 tumor protein, -0,0694611 15,23544434 0,0186937 0,30902502 translationally-controlled 1

1182 10617 STAMBP STAM binding protein -0,0839521 7,110596717 0,0187098 0,30902502 1183 55188 RIC8B RIC8 guanine nucleotide 0,14900054 5,583695064 0,0187168 0,30902502 exchange factor B

1184 1161 ERCC8 excision repair cross- -0,2010385 4,674233128 0,018726 0,30902502 complementation group 8

1185 25989 ULK3 unc-51 like kinase 3 0,16889023 5,480791547 0,0187369 0,30902502 1186 171024 SYNPO2 synaptopodin 2 0,35443076 8,857113629 0,0187771 0,30918552 1187 57508 INTS2 integrator complex subunit 0,15112172 8,135162323 0,0187783 0,30918552 2 1188 54707 GPN2 GPN-loop GTPase 2 -0,2710011 5,913792877 0,0188109 0,3094607 1189 384 ARG2 arginase 2 -0,1295214 2,34177038 0,0188651 0,31009215 1190 1E+08 RP11- uncharacterized 0,17873364 2,605372909 0,0188977 0,31012228 35G9.3 LOC100505549 1191 5774 PTPN3 protein tyrosine -0,3488308 5,810645265 0,0189034 0,31012228 phosphatase, non- receptor type 3 1192 6868 ADAM17 ADAM metallopeptidase 0,20991502 5,239521326 0,0189145 0,31012228 domain 17

1193 128338 DRAM2 DNA-damage regulated -0,1204845 10,32665621 0,0189485 0,31023836 autophagy modulator 2 1194 10491 CRTAP cartilage associated 0,15613961 10,46072141 0,0189646 0,31023836 protein 1195 57583 TMEM18 transmembrane protein 0,16509747 9,355954938 0,0189692 0,31023836 1 181 1196 54884 RETSAT retinol saturase (all-trans- 0,13769077 11,80366378 0,0189978 0,31044591 retinol 13,14-reductase)

1197 3218 HOXB8 homeobox B8 -0,1343004 2,405057843 0,0190532 0,31082782 1198 2617 GARS glycyl-tRNA synthetase 0,22113546 10,65275411 0,0190662 0,31082782 1199 23642 SNHG1 small nucleolar RNA host -0,2899997 8,902124018 0,0190769 0,31082782 gene 1 (non-protein coding) 1200 7533 YWHAH tyrosine 3- 0,2918365 9,252913638 0,0190978 0,31082782 monooxygenase/tryptoph an 5-monooxygenase activation protein, eta

1201 1E+08 MIR4458 MIR4458 host gene (non- -0,1598972 3,380047904 0,0191007 0,31082782 HG protein coding) 1202 26959 HBP1 HMG-box transcription -0,1630822 11,41794326 0,0191688 0,311676 factor 1 1203 51257 MARCH2 membrane-associated ring 0,20514183 8,982523307 0,0192128 0,31213292 finger (C3HC4) 2, E3 ubiquitin protein ligase

1204 23743 BHMT2 betaine--homocysteine S- 0,28334552 10,49141913 0,0192553 0,31238992 methyltransferase 2 1205 728568 C12orf73 chromosome 12 open -0,1289048 5,630686991 0,0192606 0,31238992 reading frame 73 1206 9960 USP3 ubiquitin specific -0,1510905 8,417272758 0,0193254 0,3131799 peptidase 3 1207 7295 TXN thioredoxin 0,3469048 11,89146128 0,01937 0,31328146 1208 9921 RNF10 ring finger protein 10 0,15473905 9,114571664 0,0193968 0,31328146 1209 137872 ADHFE1 alcohol dehydrogenase, -0,3785249 8,420664898 0,019399 0,31328146 iron containing, 1

1210 11326 VSIG4 V-set and immunoglobulin 0,65908974 8,501525805 0,0194223 0,31328146 domain containing 4

1211 6730 SRP68 signal recognition particle -0,1352901 9,185366301 0,0194452 0,31328146 68kDa 1212 57335 ZNF286A zinc finger protein 286A -0,0485214 2,208232613 0,0194504 0,31328146

1213 1459 CSNK2A2 casein kinase 2, alpha -0,2504353 7,874610676 0,0194515 0,31328146 prime polypeptide 1214 51809 GALNT7 UDP-N-acetyl-alpha-D- 0,27520594 7,200277408 0,0194671 0,31328146 galactosamine:polypeptide N- acetylgalactosaminyltransf erase 7 (GalNAc-T7) 1215 57403 RAB22A RAB22A, member RAS 0,13063036 8,6076168 0,0194802 0,31328146 oncogene family 1216 728613 LOC7286 programmed cell death 6 0,28630489 2,400902872 0,0195045 0,31328146 13 pseudogene 1217 284759 SIRPB2 signal-regulatory protein 0,37543045 2,670009718 0,0195353 0,31328146 beta 2 1218 10463 SLC30A9 solute carrier family 30 -0,0576952 10,13929823 0,0195686 0,31328146 (zinc transporter), member 9 1219 4214 MAP3K1 mitogen-activated protein 0,1469104 5,256092687 0,0195773 0,31328146 kinase kinase kinase 1, E3 ubiquitin protein ligase

1220 7164 TPD52L1 tumor protein D52-like 1 -0,4026562 7,887828499 0,0195984 0,31328146

1221 988 CDC5L cell division cycle 5-like -0,1127205 7,611282536 0,0195999 0,31328146 1222 9559 VPS26A vacuolar protein sorting 26 -0,0632712 12,34810047 0,0196082 0,31328146 homolog A (S. pombe)

1223 1E+08 LOC1002 uncharacterized -0,2669777 5,834431956 0,0196308 0,31328146 89230 LOC100289230 1224 8996 NOL3 nucleolar protein 3 0,16327862 7,735408583 0,0196362 0,31328146 (apoptosis repressor with CARD domain) 1225 1E+08 LOC1009 uncharacterized 0,27388609 7,305328736 0,0196362 0,31328146 96412 LOC100996412 1226 10229 COQ7 coenzyme Q7 homolog, -0,0603377 5,405747611 0,0196651 0,31348721 ubiquinone (yeast) 1227 509 ATP5C1 ATP synthase, H+ -0,1038677 12,25179281 0,019702 0,31381901 transporting, mitochondrial F1 complex, gamma polypeptide 1

1228 8087 FXR1 fragile X mental -0,1101982 6,53073436 0,0197297 0,3140049 retardation, autosomal homolog 1 1229 9588 PRDX6 peroxiredoxin 6 -0,1899195 13,53393417 0,0198023 0,31478399 1230 23241 PACS2 phosphofurin acidic cluster -0,4310472 6,496319594 0,0198109 0,31478399 sorting protein 2

1231 1E+08 KRBOX1 KRAB box domain -0,3269549 4,206418617 0,0198281 0,31480172 containing 1 1232 64121 RRAGC Ras-related GTP binding C -0,1526862 11,08397219 0,0198583 0,31502481

1233 4094 MAF v-maf avian 0,16277209 7,629367544 0,0198807 0,31512442 musculoaponeurotic fibrosarcoma oncogene homolog 1234 2639 GCDH glutaryl-CoA -0,2756045 6,66538412 0,0199001 0,31517685 dehydrogenase 1235 6856 SYPL1 synaptophysin-like 1 -0,1355087 10,39671747 0,0199383 0,31528946 1236 56994 CHPT1 choline -0,1447019 11,09666816 0,0199612 0,31528946 phosphotransferase 1 1237 54566 EPB41L4 erythrocyte membrane -0,3470319 7,324442804 0,0199724 0,31528946 B protein band 4.1 like 4B 1238 23466 CBX6 chromobox homolog 6 0,12854662 7,887006783 0,0199796 0,31528946 1239 665 BNIP3L BCL2/adenovirus E1B -0,1863328 13,27847949 0,0199879 0,31528946 19kDa interacting protein 3-like 1240 22888 UBOX5 U-box domain containing 5 -0,123792 3,514853617 0,0200315 0,3157223

1241 197259 MLKL mixed lineage kinase 0,26113551 6,639380808 0,020064 0,31597276 domain-like 1242 6018 RLF rearranged L-myc fusion -0,1207108 7,136193012 0,0200932 0,31597276

1243 80832 APOL4 apolipoprotein L, 4 -0,5679073 2,82035487 0,0201053 0,31597276 1244 113 ADCY7 adenylate cyclase 7 0,21774066 7,626778865 0,0201121 0,31597276 1245 6821 SUOX sulfite oxidase -0,3130787 6,342099496 0,0201438 0,31621769 1246 11186 RASSF1 Ras association 0,06760821 7,351152952 0,0201993 0,31682417 (RalGDS/AF-6) domain family member 1 1247 51054 PLEKHA8 pleckstrin homology 0,17231659 8,079275864 0,0202344 0,31682417 P1 domain containing, family A member 8 pseudogene 1

1248 4258 MGST2 microsomal glutathione S- -0,1381122 10,23036305 0,0202436 0,31682417 transferase 2

1249 57534 MIB1 mindbomb E3 ubiquitin -0,0953727 8,721236825 0,0202473 0,31682417 protein ligase 1 1250 92106 OXNAD1 oxidoreductase NAD- -0,2148073 6,643591045 0,0202837 0,31713975 binding domain containing 1 1251 113402 SFT2D1 SFT2 domain containing 1 -0,1092841 10,82119791 0,0203254 0,31753719

1252 826 CAPNS1 calpain, small subunit 1 0,19799551 10,03449162 0,0204079 0,31837764 1253 6362 CCL18 chemokine (C-C motif) 1,03834989 5,686512771 0,0204245 0,31837764 ligand 18 (pulmonary and activation-regulated)

1254 9646 CTR9 CTR9, Paf1/RNA 0,07009905 10,16382578 0,0204287 0,31837764 polymerase II complex component 1255 103 ADAR adenosine deaminase, 0,14313357 10,1457764 0,0204443 0,31837764 RNA-specific 1256 22926 ATF6 activating transcription 0,13439134 8,139739482 0,0204747 0,31851509 factor 6 1257 158471 PRUNE2 prune homolog 2 -0,7059081 2,812769889 0,0205011 0,31851509 (Drosophila) 1258 51527 GSKIP GSK3B interacting protein 0,15634714 9,552038016 0,020502 0,31851509

1259 55831 EMC3 ER membrane protein -0,1708078 11,31927328 0,020527 0,31864965 complex subunit 3 1260 4215 MAP3K3 mitogen-activated protein 0,14194946 7,748854034 0,0206025 0,31956696 kinase kinase kinase 3

1261 10082 GPC6 glypican 6 -0,1561944 7,259856335 0,0206656 0,32018148 1262 9552 SPAG7 sperm associated antigen -0,1026364 9,046358539 0,02069 0,32018148 7 1263 5321 PLA2G4A phospholipase A2, group 0,30620534 9,874427156 0,0206912 0,32018148 IVA (cytosolic, calcium- dependent) 1264 9766 KIAA024 KIAA0247 0,17790882 8,354132361 0,0207229 0,32041804 7 1265 7107 GPR137B G protein-coupled 0,48817582 8,590922613 0,0207786 0,32102487 receptor 137B 1266 391712 TRIM61 tripartite motif containing -0,2881655 3,173945373 0,0208045 0,32104277 61 1267 4090 SMAD5 SMAD family member 5 -0,1244676 8,450166342 0,0208126 0,32104277 1268 23588 KLHDC2 kelch domain containing 2 -0,1356573 11,52033219 0,0208307 0,32106934

1269 126133 ALDH16A aldehyde dehydrogenase 0,21065132 4,919828965 0,020896 0,32182145 1 16 family, member A1

1270 10488 CREB3 cAMP responsive element 0,210541 7,441767577 0,0209201 0,32193752 binding protein 3

1271 22856 CHSY1 chondroitin sulfate 0,29098262 9,237025299 0,0209365 0,32193752 synthase 1 1272 54973 CPSF3L cleavage and -0,1021347 5,968990259 0,0210116 0,32231607 polyadenylation specific factor 3-like 1273 8835 SOCS2 suppressor of cytokine -0,4116406 7,967379477 0,0210206 0,32231607 signaling 2 1274 9849 ZNF518A zinc finger protein 518A -0,1534986 7,969955465 0,0210245 0,32231607

1275 192669 AGO3 argonaute RISC catalytic -0,354158 5,407699337 0,0210271 0,32231607 component 3 1276 23179 RGL1 ral guanine nucleotide 0,3256529 10,08981798 0,0210806 0,32288349 dissociation stimulator-like 1 1277 3600 IL15 interleukin 15 0,27360974 6,146714474 0,0211045 0,32299679 1278 9638 FEZ1 fasciculation and 0,23963978 5,784535466 0,0211773 0,3236179 elongation protein zeta 1 (zygin I) 1279 1E+08 ZMYM6N ZMYM6 neighbor -0,13192 9,423643725 0,0211787 0,3236179 B 1280 9121 SLC16A5 solute carrier family 16 0,05174103 2,299430761 0,0211948 0,3236179 (monocarboxylate transporter), member 5 1281 9263 STK17A serine/threonine kinase 0,20013977 3,910582358 0,0212443 0,32389864 17a 1282 84690 SPATA22 spermatogenesis -0,24883 2,475275016 0,0212463 0,32389864 associated 22 1283 6039 RNASE6 ribonuclease, RNase A 0,52252625 6,791708904 0,0213545 0,32529405 family, k6 1284 54331 GNG2 guanine nucleotide binding 0,17244957 5,662583523 0,0214054 0,32581547 protein (G protein), gamma 2 1285 116255 MOGAT1 monoacylglycerol O- -0,3559337 2,986750712 0,0214338 0,3258373 acyltransferase 1 1286 83666 PARP9 poly (ADP-ribose) 0,29690142 6,682437643 0,0214402 0,3258373 polymerase family, member 9 1287 196527 ANO6 anoctamin 6 -0,221911 12,21538984 0,0215013 0,32644304 1288 9188 DDX21 DEAD (Asp-Glu-Ala-Asp) 0,15395575 9,640990438 0,0215271 0,32644304 box helicase 21 1289 5734 PTGER4 prostaglandin E receptor 4 0,15372948 5,633729494 0,0215422 0,32644304 (subtype EP4)

1290 51315 KRCC1 lysine-rich coiled-coil 1 -0,135146 10,12300231 0,0215468 0,32644304 1291 140890 SREK1 splicing regulatory -0,0935228 6,532401461 0,0215671 0,32646671 glutamine/lysine-rich protein 1 1292 55133 SRBD1 S1 RNA binding domain 1 -0,1659691 7,767857996 0,0216016 0,32646671

1293 27173 SLC39A1 solute carrier family 39 0,20593928 7,545115208 0,0216235 0,32646671 (zinc transporter), member 1 1294 8464 SUPT3H suppressor of Ty 3 -0,1402293 5,726025514 0,021629 0,32646671 homolog (S. cerevisiae) 1295 10455 ECI2 enoyl-CoA delta isomerase -0,187844 10,38463994 0,0216564 0,32646671 2 1296 3105 HLA-A major histocompatibility 0,13246182 13,49618008 0,0216618 0,32646671 complex, class I, A

1297 8717 TRADD TNFRSF1A-associated via 0,11054692 7,993699633 0,0216776 0,32646671 death domain 1298 7013 TERF1 telomeric repeat binding -0,1079388 8,79227658 0,021682 0,32646671 factor (NIMA-interacting) 1

1299 166815 TIGD2 tigger transposable -0,2119268 6,809209239 0,0217079 0,32654763 element derived 2 1300 3566 IL4R interleukin 4 receptor 0,30624139 6,577490715 0,0217208 0,32654763 1301 125488 TTC39C tetratricopeptide repeat -0,2336482 6,553691899 0,0217404 0,3265899 domain 39C 1302 10914 PAPOLA poly(A) polymerase alpha -0,1266862 9,611378486 0,0217851 0,32701029

1303 9819 TSC22D2 TSC22 domain family, 0,09553754 8,512944563 0,0218115 0,32715578 member 2 1304 241 ALOX5AP arachidonate 5- 0,48403969 8,216001823 0,0218427 0,32727327 lipoxygenase-activating protein 1305 64786 TBC1D15 TBC1 domain family, -0,1100851 8,461688445 0,0218528 0,32727327 member 15 1306 1601 DAB2 Dab, mitogen-responsive 0,27710762 10,44107709 0,0218815 0,32745025 phosphoprotein, homolog 2 (Drosophila) 1307 1E+08 LOC1009 uncharacterized -0,1997913 5,293079431 0,0218982 0,32745025 96419 LOC100996419 1308 29893 PSMC3IP PSMC3 interacting protein -0,1901687 6,855733418 0,0219205 0,32753438

1309 4883 NPR3 natriuretic peptide 0,69421292 5,331727376 0,0219786 0,32793067 receptor 3 1310 201292 TRIM65 tripartite motif containing 0,20021543 4,354170046 0,0219827 0,32793067 65 1311 83460 EMC6 ER membrane protein -0,1400803 8,207399744 0,0219974 0,32793067 complex subunit 6 1312 3420 IDH3B isocitrate dehydrogenase 3 -0,1453009 9,123451294 0,022077 0,32825979 (NAD+) beta

1313 130507 UBR3 ubiquitin protein ligase E3 -0,1304871 11,01134388 0,0220876 0,32825979 component n-recognin 3 (putative) 1314 26227 PHGDH phosphoglycerate -0,4553652 8,100659507 0,0221043 0,32825979 dehydrogenase 1315 64231 MS4A6A membrane-spanning 4- 0,53362623 8,521976511 0,0221297 0,32825979 domains, subfamily A, member 6A 1316 394 ARHGAP Rho GTPase activating -0,0950597 8,658504817 0,0221329 0,32825979 5 protein 5 1317 132332 TMEM15 transmembrane protein 0,21457843 2,304281674 0,0221349 0,32825979 5 155 1318 55160 ARHGEF1 Rho guanine nucleotide 0,14525388 7,863544108 0,022137 0,32825979 0L exchange factor (GEF) 10- like 1319 286319 TUSC1 tumor suppressor -0,0992242 9,465679453 0,0221633 0,32827747 candidate 1 1320 10159 ATP6AP2 ATPase, H+ transporting, 0,1407674 12,15904154 0,022191 0,32827747 lysosomal accessory protein 2 1321 9358 ITGBL1 integrin, beta-like 1 (with -0,7385436 5,444145021 0,0222015 0,32827747 EGF-like repeat domains)

1322 8994 LIMD1 LIM domains containing 1 0,07823944 3,637729222 0,0222054 0,32827747

1323 287 ANK2 ankyrin 2, neuronal -0,4639436 9,099783318 0,0222289 0,32837628 1324 10873 ME3 malic enzyme 3, NADP(+)- -0,1310654 8,390782711 0,022249 0,32842495 dependent, mitochondrial

1325 5704 PSMC4 proteasome (prosome, 0,22029362 8,209313051 0,022327 0,3289223 macropain) 26S subunit, ATPase, 4 1326 545 ATR ataxia telangiectasia and 0,22235605 9,104463768 0,0223406 0,3289223 Rad3 related 1327 285830 HLA-F- HLA-F antisense RNA 1 -0,2016529 9,343012602 0,0223424 0,3289223 AS1 1328 11151 CORO1A coronin, actin binding 0,48762217 3,014955164 0,02235 0,3289223 protein, 1A 1329 63917 GALNT11 UDP-N-acetyl-alpha-D- 0,06957011 10,15632923 0,022429 0,32945843 galactosamine:polypeptide N- acetylgalactosaminyltransf erase 11 (GalNAc-T11)

1330 9512 PMPCB peptidase (mitochondrial -0,0539536 6,888079429 0,0224429 0,32945843 processing) beta

1331 6752 SSTR2 somatostatin receptor 2 -0,0312526 2,212813345 0,0224502 0,32945843

1332 1E+08 LOC1002 uncharacterized -0,3764759 4,301758026 0,0224539 0,32945843 70804 LOC100270804 1333 2589 GALNT1 UDP-N-acetyl-alpha-D- 0,20172791 10,10957246 0,0225042 0,32975033 galactosamine:polypeptide N- acetylgalactosaminyltransf erase 1 (GalNAc-T1) 1334 8507 ENC1 ectodermal-neural cortex 0,33320101 4,466788426 0,0225075 0,32975033 1 (with BTB domain)

1335 1629 DBT dihydrolipoamide -0,0816159 6,211817295 0,022555 0,33019859 branched chain transacylase E2 1336 81844 TRIM56 tripartite motif containing 0,21335615 7,756612198 0,0226427 0,33106647 56 1337 801 CALM1 calmodulin 1 0,14029142 12,62596153 0,0226509 0,33106647 (phosphorylase kinase, delta) 1338 1E+08 LINC0096 long intergenic non- 1,12298138 8,918549022 0,0226811 0,33106647 8 protein coding RNA 968 1339 89890 KBTBD6 kelch repeat and BTB 0,17130758 7,185795637 0,0226986 0,33106647 (POZ) domain containing 6

1340 9917 FAM20B family with sequence 0,1605494 9,099831437 0,0227166 0,33106647 similarity 20, member B 1341 349565 NMNAT3 nicotinamide nucleotide -0,1904084 5,753592447 0,022722 0,33106647 adenylyltransferase 3

1342 79078 C1orf50 chromosome 1 open -0,1857484 7,345855625 0,0227329 0,33106647 reading frame 50 1343 79065 ATG9A autophagy related 9A 0,13387282 6,96154535 0,0227743 0,33142248 1344 58527 ABRACL ABRA C-terminal like 0,4667287 8,343073533 0,0228382 0,3314373 1345 2896 GRN granulin 0,25348287 9,91524643 0,0228497 0,3314373 1346 23137 SMC5 structural maintenance of -0,1499281 7,758841628 0,0228526 0,3314373 chromosomes 5 1347 10838 ZNF275 zinc finger protein 275 -0,3037302 6,447453286 0,0228537 0,3314373 1348 57409 MIF4GD MIF4G domain containing 0,12438675 7,440746446 0,0228674 0,3314373

1349 134957 STXBP5 syntaxin binding protein 5 0,1403952 5,759431243 0,022877 0,3314373 (tomosyn) 1350 123775 C16orf46 chromosome 16 open -0,1210891 2,641609615 0,0229223 0,33169368 reading frame 46 1351 27342 RABGEF1 RAB guanine nucleotide -0,1451923 9,426796659 0,0229287 0,33169368 exchange factor (GEF) 1

1352 80314 EPC1 enhancer of polycomb -0,069081 8,679863389 0,0229747 0,33211382 homolog 1 (Drosophila) 1353 5777 PTPN6 protein tyrosine 0,4582941 6,282322424 0,0229974 0,33219568 phosphatase, non- receptor type 6 1354 4306 NR3C2 nuclear receptor subfamily -0,2538609 7,904570157 0,0230747 0,33306602 3, group C, member 2

1355 170954 PPP1R18 protein phosphatase 1, 0,17334485 7,948171071 0,0231109 0,33327645 regulatory subunit 18 1356 221908 PPP1R35 protein phosphatase 1, -0,1968975 6,958078277 0,0231364 0,33327645 regulatory subunit 35 1357 51560 RAB6B RAB6B, member RAS 0,15188694 3,650412925 0,0231404 0,33327645 oncogene family 1358 977 CD151 CD151 molecule (Raph 0,23537108 10,04685498 0,0232519 0,3346358 blood group) 1359 64083 GOLPH3 golgi phosphoprotein 3 0,09769452 11,84426354 0,0232917 0,33496157 (coat-protein) 1360 23612 PHLDA3 pleckstrin homology-like -0,2678797 9,153290946 0,0233153 0,33505482 domain, family A, member 3 1361 23129 PLXND1 plexin D1 0,19147503 9,125617873 0,0233542 0,33536652 1362 55272 IMP3 IMP3, U3 small nucleolar 0,12148384 9,131916399 0,0233885 0,33561266 ribonucleoprotein

1363 9673 SLC25A4 solute carrier family 25, 0,09407147 7,351355642 0,0234312 0,33597941 4 member 44 1364 84678 KDM2B lysine (K)-specific 0,16343394 7,411215567 0,0235119 0,33688858 demethylase 2B 1365 114757 CYGB cytoglobin -0,0605222 3,663831323 0,0235516 0,33720642 1366 7993 UBXN8 UBX domain protein 8 0,11886668 8,330273714 0,0235686 0,33720642 1367 4627 MYH9 myosin, heavy chain 9, non- 0,20856093 7,968020908 0,0236284 0,33772129 muscle 1368 30061 SLC40A1 solute carrier family 40 0,21529359 12,04810656 0,0236391 0,33772129 (iron-regulated transporter), member 1 1369 84928 TMEM20 transmembrane protein -0,1616807 8,039263028 0,023726 0,33850096 9 209 1370 10845 CLPX caseinolytic mitochondrial -0,1335258 9,365883987 0,0237437 0,33850096 matrix peptidase chaperone subunit

1371 219347 TMEM25 TMEM254 antisense RNA 1 0,15583648 2,478971305 0,0237552 0,33850096 4-AS1 1372 3222 HOXC5 homeobox C5 0,18781275 4,237405128 0,023763 0,33850096 1373 4694 NDUFA1 NADH dehydrogenase -0,100903 11,95962467 0,0238244 0,33912935 (ubiquinone) 1 alpha subcomplex, 1, 7.5kDa 1374 5241 PGR progesterone receptor -0,0242322 2,619654221 0,0239003 0,33996174 1375 2222 FDFT1 farnesyl-diphosphate -0,22517 11,50816338 0,0239219 0,34002105 farnesyltransferase 1 1376 7263 TST thiosulfate -0,2061022 10,72958476 0,0239863 0,3403008 sulfurtransferase (rhodanese) 1377 22955 SCMH1 sex comb on midleg -0,1619936 6,915595535 0,0239872 0,3403008 homolog 1 (Drosophila) 1378 10844 TUBGCP2 tubulin, gamma complex -0,0758107 5,671461104 0,0240057 0,3403008 associated protein 2

1379 84681 HINT2 histidine triad nucleotide -0,1453576 10,01900141 0,0240112 0,3403008 binding protein 2

1380 55313 CPPED1 calcineurin-like 0,24620489 7,512582056 0,0240727 0,34067526 phosphoesterase domain containing 1 1381 7733 ZNF180 zinc finger protein 180 -0,1056485 4,551880237 0,0240873 0,34067526 1382 93973 ACTR8 ARP8 actin-related protein -0,0823565 4,381204524 0,0240899 0,34067526 8 homolog (yeast)

1383 253827 MSRB3 methionine sulfoxide 0,2577275 9,011722843 0,0241445 0,34103216 reductase B3 1384 56986 DTWD1 DTW domain containing 1 -0,0989964 7,62929798 0,0241674 0,34103216

1385 252969 NEIL2 nei endonuclease VIII-like 0,31983861 8,636105311 0,0241709 0,34103216 2 (E. coli) 1386 64087 MCCC2 methylcrotonoyl-CoA -0,196888 7,616712485 0,0241849 0,34103216 carboxylase 2 (beta) 1387 7462 LAT2 linker for activation of T 0,13622809 3,195728995 0,0242527 0,34174161 cells family, member 2

1388 6124 RPL4 ribosomal protein L4 -0,0996818 13,99229522 0,0243245 0,34199231 1389 9205 ZMYM5 zinc finger, MYM-type 5 -0,1390548 6,428443552 0,024343 0,34199231 1390 10468 FST follistatin -0,3022661 6,891823646 0,0243452 0,34199231 1391 80124 VCPIP1 valosin containing protein -0,0826832 2,325097189 0,0243709 0,34199231 (p97)/p47 complex interacting protein 1 1392 79632 FAM184 family with sequence -0,3994372 6,389074637 0,0243754 0,34199231 A similarity 184, member A

1393 1192 CLIC1 chloride intracellular 0,19701836 11,84081124 0,0243755 0,34199231 channel 1 1394 8878 SQSTM1 sequestosome 1 0,20319976 7,978174213 0,0244064 0,34210149 1395 83992 CTTNBP2 cortactin binding protein 2 -0,2122005 7,250170131 0,0244434 0,34210149

1396 29929 ALG6 ALG6, alpha-1,3- 0,16617669 7,839345576 0,02445 0,34210149 glucosyltransferase 1397 2217 FCGRT Fc fragment of IgG, 0,15349944 9,877203011 0,0244533 0,34210149 receptor, transporter, alpha 1398 64768 IPPK inositol 1,3,4,5,6- 0,09973822 2,413920525 0,024536 0,34246571 pentakisphosphate 2- kinase 1399 8611 PPAP2A phosphatidic acid 0,226491 12,66673423 0,0245398 0,34246571 phosphatase type 2A 1400 10974 ADIRF adipogenesis regulatory -0,2108713 14,12122082 0,0245402 0,34246571 factor 1401 11062 DUS4L dihydrouridine synthase 4- -0,2311249 5,144595891 0,0245495 0,34246571 like (S. cerevisiae)

1402 10788 IQGAP2 IQ motif containing 0,49450828 8,657579088 0,0246063 0,34261681 GTPase activating protein 2 1403 374986 FAM73A family with sequence -0,1277995 8,581187705 0,024607 0,34261681 similarity 73, member A

1404 5786 PTPRA protein tyrosine -0,2105217 6,550177889 0,0246237 0,34261681 phosphatase, receptor type, A 1405 375743 PTAR1 protein prenyltransferase 0,07770217 7,061436508 0,0246423 0,34261681 alpha subunit repeat containing 1

1406 79691 QTRTD1 queuine tRNA- 0,18346789 6,296472848 0,0246479 0,34261681 ribosyltransferase domain containing 1 1407 282679 AQP11 aquaporin 11 0,20402105 3,33621285 0,0247334 0,34355997 1408 3460 IFNGR2 interferon gamma -0,166981 10,90217731 0,0247574 0,34364912 receptor 2 (interferon gamma transducer 1) 1409 51205 ACP6 acid phosphatase 6, -0,4165069 6,326479959 0,0247971 0,34395634 lysophosphatidic 1410 56204 FAM214 family with sequence -0,2555889 11,16527746 0,024864 0,34464035 A similarity 214, member A

1411 728489 DNLZ DNL-type zinc finger 0,18023614 7,163409542 0,0248909 0,34476846 1412 3659 IRF1 interferon regulatory 0,19174816 5,641366483 0,0249402 0,34495635 factor 1 1413 25942 SIN3A SIN3 transcription -0,1576099 6,112546305 0,0249536 0,34495635 regulator family member A

1414 643314 KIAA075 KIAA0754 0,44083105 6,188478987 0,0249742 0,34495635 4 1415 2120 ETV6 ets variant 6 0,16938289 4,998318055 0,0249751 0,34495635 1416 10226 PLIN3 perilipin 3 0,18244613 8,124996659 0,0250225 0,34506573 1417 9477 MED20 mediator complex subunit 0,05764206 3,340252395 0,0250246 0,34506573 20 1418 8797 TNFRSF1 tumor necrosis factor 0,28584463 3,223418705 0,025036 0,34506573 0A receptor superfamily, member 10a 1419 7852 CXCR4 chemokine (C-X-C motif) 0,6662995 3,78939521 0,025055 0,34508504 receptor 4 1420 3507 IGHM immunoglobulin heavy 0,63656921 4,125244528 0,0251211 0,345751 constant mu 1421 10581 IFITM2 interferon induced 0,27839971 11,33747624 0,0251394 0,34576005 transmembrane protein 2

1422 153129 SLC38A9 solute carrier family 38, 0,20572656 6,492488816 0,0252005 0,34635634 member 9 1423 94274 PPP1R14 protein phosphatase 1, -0,3609448 10,47189207 0,0252374 0,34646266 A regulatory (inhibitor) subunit 14A 1424 9332 CD163 CD163 molecule 0,6178865 9,526319725 0,0252437 0,34646266 1425 158046 NXNL2 nucleoredoxin-like 2 0,05092531 2,198362743 0,0253209 0,34727879 1426 201626 PDE12 phosphodiesterase 12 0,11697784 7,653034406 0,0253631 0,34761307 1427 6990 DYNLT3 dynein, light chain, Tctex- 0,13111426 11,25857848 0,025404 0,34769672 type 3 1428 56262 LRRC8A leucine rich repeat 0,23885913 5,773592848 0,0254559 0,34769672 containing 8 family, member A 1429 6301 SARS seryl-tRNA synthetase -0,0440184 7,88463591 0,0254589 0,34769672 1430 92305 TMEM12 transmembrane protein 0,09533429 7,440651524 0,0254841 0,34769672 9 129 1431 653857 ACTR3C ARP3 actin-related protein -0,357301 4,239673552 0,0254905 0,34769672 3 homolog C (yeast)

1432 152007 GLIPR2 GLI pathogenesis-related 2 0,44455287 8,884425009 0,0254914 0,34769672

1433 8813 DPM1 dolichyl-phosphate -0,0910717 11,78099427 0,0254937 0,34769672 mannosyltransferase polypeptide 1, catalytic subunit 1434 10440 TIMM17 translocase of inner 0,14939374 9,072708425 0,025531 0,34796235 A mitochondrial membrane 17 homolog A (yeast) 1435 8685 MARCO macrophage receptor with 0,7829617 5,052973615 0,0255679 0,34822226 collagenous structure

1436 1267 CNP 2',3'-cyclic nucleotide 3' 0,13450022 6,332624071 0,0256102 0,34855532 phosphodiesterase 1437 56951 C5orf15 chromosome 5 open -0,1160425 11,83273541 0,0258132 0,35056918 reading frame 15 1438 1E+08 LOC1019 uncharacterized -0,1407894 2,28756041 0,0258592 0,35056918 28412 LOC101928412 1439 23451 SF3B1 splicing factor 3b, subunit -0,1608348 10,57302434 0,025863 0,35056918 1, 155kDa 1440 79411 GLB1L galactosidase, beta 1-like -0,276559 5,775835322 0,0258705 0,35056918

1441 22919 MAPRE1 microtubule-associated 0,13100004 9,619052148 0,0258732 0,35056918 protein, RP/EB family, member 1 1442 55325 UFSP2 UFM1-specific peptidase 2 -0,1392217 10,23357064 0,0258764 0,35056918

1443 9501 RPH3AL rabphilin 3A-like (without 0,23882721 5,573545241 0,0258857 0,35056918 C2 domains) 1444 3643 INSR insulin receptor -0,2183731 7,484275031 0,0259052 0,35056918 1445 26468 LHX6 LIM homeobox 6 0,34349566 4,58334438 0,0259196 0,35056918 1446 3032 HADHB hydroxyacyl-CoA -0,1255369 12,69292423 0,0259755 0,35106459 dehydrogenase/3-ketoacyl- CoA thiolase/enoyl-CoA hydratase (trifunctional protein), beta subunit

1447 10724 MGEA5 meningioma expressed -0,2586064 10,0264281 0,0260059 0,35106459 antigen 5 (hyaluronidase)

1448 400916 CHCHD10 coiled-coil-helix-coiled-coil- -0,3318699 9,549410106 0,0260101 0,35106459 helix domain containing 10

1449 3479 IGF1 insulin-like growth factor 1 -0,3757163 11,63140432 0,0260954 0,35197309 (somatomedin C)

1450 11161 C14orf1 chromosome 14 open -0,2251269 6,900147041 0,0261331 0,35202294 reading frame 1 1451 55181 SMG8 SMG8 nonsense mediated -0,1561876 6,987849942 0,0261351 0,35202294 mRNA decay factor

1452 10558 SPTLC1 serine -0,1184131 6,940747678 0,0261833 0,35212027 palmitoyltransferase, long chain base subunit 1

1453 127687 C1orf122 chromosome 1 open 0,17123045 9,34565316 0,0261911 0,35212027 reading frame 122 1454 56889 TM9SF3 transmembrane 9 0,12325019 11,068981 0,0261964 0,35212027 superfamily member 3 1455 286437 LOC2864 uncharacterized 0,25258709 7,117811334 0,0263385 0,35337001 37 LOC286437 1456 23042 PDXDC1 pyridoxal-dependent 0,1417481 8,984290578 0,0263433 0,35337001 decarboxylase domain containing 1 1457 643866 CBLN3 cerebellin 3 precursor 0,11731879 2,284541232 0,0263436 0,35337001 1458 1915 EEF1A1 eukaryotic translation 0,13950932 9,352883526 0,0264455 0,35449339 elongation factor 1 alpha 1

1459 56658 TRIM39 tripartite motif containing -0,2135936 6,984691971 0,0264737 0,3546279 39 1460 889 KRIT1 KRIT1, ankyrin repeat -0,1059923 8,732916214 0,0265633 0,35492597 containing 1461 378 ARF4 ADP-ribosylation factor 4 0,185028 12,08739671 0,0265642 0,35492597

1462 29946 SERTAD3 SERTA domain containing 0,20941404 6,158398042 0,0265682 0,35492597 3 1463 55652 SLC48A1 solute carrier family 48 0,05427476 4,139311364 0,0265686 0,35492597 (heme transporter), member 1 1464 1E+08 GS1- uncharacterized 0,08586509 8,507015942 0,0265917 0,35499208 251I9.4 LOC100506365 1465 81873 ARPC5L actin related protein 2/3 0,1185388 8,295101432 0,0266346 0,3550396 complex, subunit 5-like

1466 57192 MCOLN1 mucolipin 1 0,13972478 7,299571018 0,0266856 0,3550396

1467 91746 YTHDC1 YTH domain containing 1 -0,1030528 6,918371671 0,0266988 0,3550396

1468 5162 PDHB pyruvate dehydrogenase -0,164653 10,66107382 0,0267127 0,3550396 (lipoamide) beta

1469 285016 FAM150 family with sequence -0,4544316 2,627136093 0,026743 0,3550396 B similarity 150, member B

1470 929 CD14 CD14 molecule 0,51600715 9,843505191 0,0267602 0,3550396 1471 64376 IKZF5 IKAROS family zinc finger 5 -0,0922402 6,496221959 0,0267817 0,3550396 (Pegasus) 1472 84142 FAM175 family with sequence -0,1873883 7,337799973 0,0267842 0,3550396 A similarity 175, member A

1473 285148 IAH1 isoamyl acetate- -0,1166216 10,61069794 0,0267931 0,3550396 hydrolyzing esterase 1 homolog (S. cerevisiae) 1474 3551 IKBKB inhibitor of kappa light 0,12897793 5,760279863 0,0268012 0,3550396 polypeptide gene enhancer in B-cells, kinase beta 1475 314 AOC2 amine oxidase, copper 0,28314599 5,074991652 0,0268124 0,3550396 containing 2 (retina- specific) 1476 5187 PER1 period circadian clock 1 -0,44749 8,228432848 0,0268258 0,3550396 1477 9061 PAPSS1 3'-phosphoadenosine 5'- -0,2104122 10,34814176 0,0268314 0,3550396 phosphosulfate synthase 1

1478 115201 ATG4A autophagy related 4A, 0,1727943 6,983267681 0,0269647 0,35656221 cysteine peptidase 1479 51035 UBXN1 UBX domain protein 1 -0,0922725 4,866485345 0,0269878 0,35662617 1480 79576 NKAP NFKB activating protein -0,1126466 7,84175009 0,0270152 0,35674636 1481 90075 ZNF30 zinc finger protein 30 0,19782081 6,261395912 0,0270796 0,35684738 1482 10657 KHDRBS1 KH domain containing, -0,0881038 9,91617641 0,027086 0,35684738 RNA binding, signal transduction associated 1

1483 729359 PLIN4 perilipin 4 0,27465444 12,96581385 0,0270936 0,35684738 1484 22976 PAXIP1 PAX interacting (with -0,1230386 7,764267623 0,0270959 0,35684738 transcription-activation domain) protein 1 1485 1E+08 LINC0098 long intergenic non- 0,08692528 5,263880616 0,0271464 0,35717431 4 protein coding RNA 984 1486 7414 VCL vinculin 0,10780961 7,273973466 0,0271834 0,35717431 1487 1398 CRK v-crk avian sarcoma virus 0,13661004 9,207433661 0,0271957 0,35717431 CT10 oncogene homolog

1488 23321 TRIM2 tripartite motif containing -0,1314228 6,873954303 0,0272091 0,35717431 2 1489 29844 TFPT TCF3 (E2A) fusion partner 0,16965624 4,280283697 0,0272121 0,35717431 (in childhood Leukemia)

1490 90355 C5orf30 chromosome 5 open -0,6299073 9,931046692 0,0273055 0,35799293 reading frame 30 1491 2107 ETF1 eukaryotic translation 0,09599476 11,39983838 0,0273111 0,35799293 termination factor 1 1492 9931 HELZ helicase with zinc finger -0,1760622 9,219379301 0,0273687 0,35850848

1493 123016 TTC8 tetratricopeptide repeat -0,2600566 7,779228462 0,0274034 0,35872164 domain 8 1494 6051 RNPEP arginyl aminopeptidase 0,15058669 8,605793935 0,0274772 0,35944712 (aminopeptidase B) 1495 7336 UBE2V2 ubiquitin-conjugating 0,07192108 7,218016864 0,0275739 0,36047047 enzyme E2 variant 2 1496 84190 METTL25 methyltransferase like 25 -0,1935748 7,846916897 0,0276512 0,36108526

1497 90233 ZNF551 zinc finger protein 551 0,0878048 3,774647092 0,0276626 0,36108526 1498 9406 ZRANB2 zinc finger, RAN-binding -0,0879427 11,04279862 0,0276763 0,36108526 domain containing 2

1499 57017 COQ9 coenzyme Q9 -0,1653185 8,59334214 0,0277154 0,36133339 1500 55825 PECR peroxisomal trans-2-enoyl- -0,296274 10,2557634 0,0277658 0,36133339 CoA reductase 1501 10129 FRY furry homolog 0,13534283 7,24047975 0,027766 0,36133339 (Drosophila) 1502 54882 ANKHD1 ankyrin repeat and KH -0,1429715 8,76521061 0,0278436 0,36133339 domain containing 1 1503 253558 LCLAT1 lysocardiolipin 0,21985486 7,55861161 0,0278572 0,36133339 acyltransferase 1 1504 2178 FANCE Fanconi anemia, -0,0795084 2,239315833 0,027875 0,36133339 complementation group E

1505 5468 PPARG peroxisome proliferator- -0,3364039 10,99960564 0,0278772 0,36133339 activated receptor gamma

1506 79659 DYNC2H1 dynein, cytoplasmic 2, -0,1354761 5,323147767 0,0278967 0,36133339 heavy chain 1 1507 2010 EMD emerin -0,1450825 7,822425346 0,0278983 0,36133339 1508 3059 HCLS1 hematopoietic cell-specific 0,37762605 8,262217361 0,027929 0,36133339 Lyn substrate 1 1509 8871 SYNJ2 synaptojanin 2 0,05363423 2,286923687 0,0279693 0,36133339 1510 1616 DAXX death-domain associated 0,14652752 7,226179458 0,0279901 0,36133339 protein 1511 8519 IFITM1 interferon induced 0,28596933 11,00488787 0,027999 0,36133339 transmembrane protein 1

1512 284611 FAM102 family with sequence 0,30245807 9,008174753 0,0280074 0,36133339 B similarity 102, member B

1513 4059 BCAM basal cell adhesion 0,08882067 4,461640287 0,0280193 0,36133339 molecule (Lutheran blood group) 1514 6801 STRN striatin, calmodulin 0,05935798 6,452798073 0,028025 0,36133339 binding protein 1515 51300 TIMMDC translocase of inner 0,0808704 11,63527501 0,0280308 0,36133339 1 mitochondrial membrane domain containing 1

1516 7748 ZNF195 zinc finger protein 195 -0,220426 7,124076644 0,0280377 0,36133339 1517 64430 PCNXL4 pecanex-like 4 -0,0739281 6,738496971 0,0280466 0,36133339 (Drosophila) 1518 23214 XPO6 exportin 6 0,12209253 8,029471474 0,0280697 0,36139234 1519 51634 RBMX2 RNA binding motif protein, -0,1254859 7,618995158 0,0281756 0,3621451 X-linked 2 1520 57291 DANCR differentiation -0,2469462 7,34545386 0,028211 0,3621451 antagonizing non-protein coding RNA 1521 55768 NGLY1 N-glycanase 1 -0,1279771 9,398763712 0,0282124 0,3621451 1522 2627 GATA6 GATA binding protein 6 -0,2526243 7,069735299 0,0282617 0,3621451 1523 51338 MS4A4A membrane-spanning 4- 0,56347678 8,210197855 0,028267 0,3621451 domains, subfamily A, member 4A 1524 6341 SCO1 SCO1 cytochrome c -0,2183256 7,978683463 0,0282692 0,3621451 oxidase assembly protein

1525 10371 SEMA3A sema domain, -0,3790216 5,405058931 0,0282915 0,3621451 immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A

1526 7706 TRIM25 tripartite motif containing 0,131791 6,599271836 0,0283151 0,3621451 25 1527 64757 MARC1 mitochondrial amidoxime -0,2752394 11,83759863 0,0283346 0,3621451 reducing component 1

1528 55100 WDR70 WD repeat domain 70 -0,1350127 8,211966286 0,0283512 0,3621451 1529 54602 NDFIP2 Nedd4 family interacting -0,2060743 8,102773495 0,0283937 0,3621451 protein 2 1530 6197 RPS6KA3 ribosomal protein S6 0,17852117 8,630240068 0,0283995 0,3621451 kinase, 90kDa, polypeptide 3 1531 55605 KIF21A kinesin family member -0,2047492 7,422393599 0,0284032 0,3621451 21A 1532 34 ACADM acyl-CoA dehydrogenase, C- -0,284222 11,91328169 0,0284082 0,3621451 4 to C-12 straight chain

1533 55005 RMND1 required for meiotic -0,2089693 8,323641716 0,0284195 0,3621451 nuclear division 1 homolog (S. cerevisiae) 1534 121536 AEBP2 AE binding protein 2 -0,0975384 4,623898503 0,0284246 0,3621451 1535 55854 ZC3H15 zinc finger CCCH-type -0,0691515 10,87816451 0,0285084 0,36237679 containing 15 1536 4725 NDUFS5 NADH dehydrogenase -0,1032706 12,43557689 0,0285425 0,36237679 (ubiquinone) Fe-S protein 5, 15kDa (NADH-coenzyme Q reductase) 1537 55568 GALNT10 UDP-N-acetyl-alpha-D- 0,22514429 4,464780118 0,0285458 0,36237679 galactosamine:polypeptide N- acetylgalactosaminyltransf erase 10 (GalNAc-T10)

1538 140459 ASB6 ankyrin repeat and SOCS 0,0440581 2,440079383 0,0285623 0,36237679 box containing 6 1539 89927 C16orf45 chromosome 16 open 0,21931352 7,619550112 0,028575 0,36237679 reading frame 45 1540 80854 SETD7 SET domain containing 0,10350085 12,01959741 0,0285847 0,36237679 (lysine methyltransferase) 7 1541 11179 ZNF277 zinc finger protein 277 -0,1301488 8,263046839 0,0286003 0,36237679 1542 550 AUP1 ancient ubiquitous protein 0,0686623 9,845250662 0,0286097 0,36237679 1 1543 23394 ADNP activity-dependent -0,0892889 9,387130499 0,0286196 0,36237679 neuroprotector homeobox

1544 7561 ZNF14 zinc finger protein 14 -0,2436151 6,747098224 0,0286282 0,36237679 1545 4522 MTHFD1 methylenetetrahydrofolat -0,2521626 11,59283935 0,0286592 0,3625346 e dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase 1546 23197 FAF2 Fas associated factor -0,1017793 7,118683721 0,0287046 0,36287385 family member 2 1547 11276 SYNRG synergin, gamma -0,0661844 4,422986406 0,0287417 0,36289702 1548 7572 ZNF24 zinc finger protein 24 -0,0563091 6,180333432 0,0287436 0,36289702 1549 286053 NSMCE2 non-SMC element 2, -0,1881432 8,092270002 0,028822 0,36365163 MMS21 homolog (S. cerevisiae) 1550 9049 AIP aryl hydrocarbon receptor -0,1080716 7,321384173 0,0288533 0,36381217 interacting protein

1551 10169 SERF2 small EDRK-rich factor 2 0,15145094 10,43658384 0,0288959 0,36411402 1552 2662 GDF10 growth differentiation 0,61152288 6,780370163 0,0289383 0,36441421 factor 10 1553 647087 C7orf73 chromosome 7 open 0,21851253 8,942300967 0,028981 0,36471636 reading frame 73 1554 2532 DARC Duffy blood group, atypical 0,40309612 8,937311045 0,0290083 0,3648257 chemokine receptor

1555 83938 C10orf11 chromosome 10 open 0,27722493 7,385684705 0,0290333 0,36490533 reading frame 11 1556 54020 SLC37A1 solute carrier family 37 0,11925158 4,070334645 0,0291212 0,36577372 (glucose-6-phosphate transporter), member 1 1557 25900 IFFO1 intermediate filament 0,16996075 7,106499812 0,0292207 0,36660147 family orphan 1 1558 113246 C12orf57 chromosome 12 open -0,1869571 10,88141931 0,0292246 0,36660147 reading frame 57 1559 22897 CEP164 centrosomal protein 0,13039469 4,259615708 0,029295 0,36719333 164kDa 1560 9989 PPP4R1 protein phosphatase 4, 0,13441527 9,645869883 0,0293093 0,36719333 regulatory subunit 1 1561 4976 OPA1 optic atrophy 1 (autosomal -0,1183637 8,33872207 0,0293479 0,36744093 dominant) 1562 56301 SLC7A10 solute carrier family 7 -0,7250104 6,817207285 0,0294009 0,36780568 (neutral amino acid transporter light chain, asc system), member 10

1563 254225 RNF169 ring finger protein 169 -0,1742555 7,657855851 0,0294341 0,36780568 1564 10827 FAM114 family with sequence 0,09676783 8,149339531 0,0294375 0,36780568 A2 similarity 114, member A2

1565 6945 MLX MLX, MAX dimerization -0,1797503 8,351034598 0,0294833 0,36780568 protein 1566 54799 MBTD1 mbt domain containing 1 -0,2857637 7,733994794 0,0294946 0,36780568

1567 344558 SH3RF3 SH3 domain containing 0,34976753 7,691230354 0,0295042 0,36780568 ring finger 3 1568 3068 HDGF hepatoma-derived growth 0,16404405 8,900001985 0,0295088 0,36780568 factor 1569 7485 WRB tryptophan rich basic -0,1504912 10,33197289 0,029547 0,36804733 protein 1570 28962 OSTM1 osteopetrosis associated 0,29682367 8,296039109 0,0295682 0,36807717 transmembrane protein 1

1571 83955 NACAP1 nascent-polypeptide- -0,1584971 14,16642229 0,0296325 0,36864236 associated complex alpha polypeptide pseudogene 1

1572 1240 CMKLR1 chemokine-like receptor 1 0,19021246 2,674368421 0,0296627 0,36878371

1573 163859 SDE2 SDE2 telomere -0,0764685 4,434863544 0,0297923 0,36993316 maintenance homolog (S. pombe) 1574 23659 PLA2G15 phospholipase A2, group 0,34359451 5,918983465 0,029793 0,36993316 XV 1575 91768 CABLES1 Cdk5 and Abl enzyme -0,290006 7,655561656 0,0298539 0,37045411 substrate 1 1576 8876 VNN1 vanin 1 0,35424148 3,751791914 0,0300157 0,37222458 1577 1E+08 RARA- RARA antisense RNA 1 0,22607086 3,749466522 0,0300415 0,37230897 AS1 1578 79648 MCPH1 microcephalin 1 -0,1174754 3,807369867 0,0300949 0,37273445 1579 54981 NMRK1 nicotinamide riboside -0,1891727 10,66184629 0,0301352 0,37299763 kinase 1 1580 55051 NRDE2 NRDE-2, necessary for RNA -0,1073024 3,580594762 0,0301699 0,37319079 interference, domain containing 1581 338758 LINC0093 long intergenic non- 0,24141132 5,589014126 0,0302256 0,37364217 6 protein coding RNA 936 1582 10007 GNPDA1 glucosamine-6-phosphate 0,19143189 8,400582217 0,0302636 0,37387585 deaminase 1 1583 222236 NAPEPLD N-acyl 0,14032354 4,953217255 0,0303986 0,37530711 phosphatidylethanolamine phospholipase D 1584 85313 PPIL4 peptidylprolyl isomerase -0,197715 8,952781719 0,0304214 0,37535037 (cyclophilin)-like 4

1585 7409 VAV1 vav 1 guanine nucleotide 0,29596305 2,806837698 0,0304547 0,37552489 exchange factor

1586 5919 RARRES2 retinoic acid receptor -0,2140112 13,50042542 0,0305041 0,37589687 responder (tazarotene induced) 2 1587 90459 ERI1 exoribonuclease 1 0,12466721 6,62971256 0,0306291 0,37702746 1588 10445 MCRS1 microspherule protein 1 0,16388338 5,54300102 0,0306392 0,37702746

1589 506 ATP5B ATP synthase, H+ -0,1946549 12,48935478 0,0306537 0,37702746 transporting, mitochondrial F1 complex, beta polypeptide

1590 28966 SNX24 sorting nexin 24 0,31233058 4,562901792 0,0307031 0,37739705 1591 23057 NMNAT2 nicotinamide nucleotide -0,5646329 4,161406058 0,0307648 0,3779179 adenylyltransferase 2

1592 84524 ZC3H8 zinc finger CCCH-type -0,1989814 5,034483408 0,0308238 0,378275 containing 8 1593 23592 LEMD3 LEM domain containing 3 -0,1009308 9,666624146 0,0308515 0,378275

1594 150771 ITPRIPL1 inositol 1,4,5- -0,0194821 2,185866162 0,0308519 0,378275 trisphosphate receptor interacting protein-like 1

1595 3371 TNC tenascin C 0,17704816 2,930577268 0,0309041 0,37853553 1596 3587 IL10RA interleukin 10 receptor, 0,43156594 8,34293308 0,0309119 0,37853553 alpha 1597 65220 NADK NAD kinase 0,12299362 4,652021941 0,03107 0,38023278 1598 10487 CAP1 CAP, adenylate cyclase- 0,16599686 11,82873247 0,0311761 0,38126864 associated protein 1 (yeast) 1599 10390 CEPT1 choline/ethanolamine -0,1328161 10,26589736 0,0311936 0,38126864 phosphotransferase 1 1600 1E+08 LOC1019 uncharacterized 0,4042842 8,985141028 0,0312163 0,38130765 29726 LOC101929726 1601 55039 TRMT12 tRNA methyltransferase 12 0,15172347 7,477107681 0,0312973 0,38198075 homolog (S. cerevisiae)

1602 4097 MAFG v-maf avian 0,10212705 4,75460303 0,0313105 0,38198075 musculoaponeurotic fibrosarcoma oncogene homolog G 1603 57559 STAMBPL STAM binding protein-like -0,1952934 5,556395439 0,0314571 0,38287501 1 1 1604 10391 CORO2B coronin, actin binding -0,4409211 7,527289297 0,0314638 0,38287501 protein, 2B 1605 23078 VWA8 von Willebrand factor A -0,1604833 6,970405721 0,0314983 0,38287501 domain containing 8 1606 80343 SEL1L2 sel-1 suppressor of lin-12- -0,7690063 7,847200852 0,0315056 0,38287501 like 2 (C. elegans) 1607 11221 DUSP10 dual specificity 0,41918141 5,756032633 0,031542 0,38287501 phosphatase 10 1608 728448 PPIEL peptidylprolyl isomerase E- -0,0822993 2,978406824 0,0315458 0,38287501 like pseudogene

1609 151903 CCDC12 coiled-coil domain -0,093022 9,499656384 0,0315766 0,38287501 containing 12 1610 23168 RTF1 Rtf1, Paf1/RNA -0,0478031 6,83845974 0,0316021 0,38287501 polymerase II complex component, homolog (S. cerevisiae) 1611 51181 DCXR dicarbonyl/L-xylulose -0,2605267 8,950782898 0,0316585 0,38287501 reductase 1612 2744 GLS glutaminase 0,22027824 6,782608404 0,0316621 0,38287501 1613 63899 NSUN3 NOP2/Sun domain family, 0,24398011 4,251621035 0,0316728 0,38287501 member 3 1614 54862 CC2D1A coiled-coil and C2 domain 0,0333478 3,300129418 0,0316737 0,38287501 containing 1A 1615 79817 MOB3B MOB kinase activator 3B -0,1914621 7,238475666 0,0316875 0,38287501

1616 406 ARNTL aryl hydrocarbon receptor -0,4663287 5,007410887 0,0316938 0,38287501 nuclear translocator-like

1617 11345 GABARA GABA(A) receptor- 0,08404241 12,06743395 0,0317021 0,38287501 PL2 associated protein-like 2

1618 9223 MAGI1 membrane associated -0,1018946 5,317107473 0,0317062 0,38287501 guanylate kinase, WW and PDZ domain containing 1

1619 10475 TRIM38 tripartite motif containing 0,18641635 6,938071437 0,0317517 0,38287501 38 1620 6924 TCEB3 transcription elongation -0,1438363 7,844450302 0,0317579 0,38287501 factor B (SIII), polypeptide 3 (110kDa, elongin A)

1621 23607 CD2AP CD2-associated protein -0,0315319 6,141377245 0,0317654 0,38287501 1622 26873 OPLAH 5-oxoprolinase (ATP- -0,2397046 6,835525604 0,0317756 0,38287501 hydrolysing) 1623 444 ASPH aspartate beta- 0,0763602 11,3544662 0,0318148 0,38299087 hydroxylase 1624 55602 CDKN2AI CDKN2A interacting -0,1671918 8,225714319 0,0318245 0,38299087 P protein 1625 53938 PPIL3 peptidylprolyl isomerase -0,1045073 9,102250568 0,0318731 0,38299305 (cyclophilin)-like 3

1626 3903 LAIR1 leukocyte-associated 0,21010617 7,716320365 0,0318914 0,38299305 immunoglobulin-like receptor 1 1627 7415 VCP valosin containing protein 0,09805302 9,491437143 0,0318967 0,38299305

1628 85315 PAQR8 progestin and adipoQ 0,15040956 5,185205741 0,031917 0,38299305 receptor family member VIII 1629 3123 HLA- major histocompatibility 0,37322163 12,15281835 0,0319226 0,38299305 DRB1 complex, class II, DR beta 1

1630 11034 DSTN destrin (actin 0,07379396 13,41893826 0,0319491 0,38307504 depolymerizing factor) 1631 3069 HDLBP high density lipoprotein 0,09307711 7,638610832 0,0320309 0,38382079 binding protein

1632 10979 FERMT2 fermitin family member 2 -0,1383163 11,79753828 0,0320755 0,38402031

1633 328 APEX1 APEX nuclease -0,1212184 11,03643431 0,0320966 0,38402031 (multifunctional DNA repair enzyme) 1 1634 10652 YKT6 YKT6 v-SNARE homolog (S. 0,33603738 6,941568491 0,0321065 0,38402031 cerevisiae) 1635 122773 KLHDC1 kelch domain containing 1 -0,1932953 7,241489705 0,0321296 0,38406132

1636 64795 RMND5A required for meiotic -0,1204222 6,107952037 0,0322198 0,38483866 nuclear division 5 homolog A (S. cerevisiae)

1637 1E+08 LOC1019 uncharacterized -0,0868481 2,290857942 0,032234 0,38483866 29480 LOC101929480 1638 50862 RNF141 ring finger protein 141 0,17703812 9,879883356 0,0322613 0,38492974 1639 84981 MIR22HG MIR22 host gene (non- 0,2230148 11,03009989 0,0322815 0,38493529 protein coding) 1640 51808 PHAX phosphorylated adaptor -0,0867869 8,831576696 0,0323504 0,38512031 for RNA export 1641 285362 SUMF1 sulfatase modifying factor 0,14295027 10,64227984 0,0323794 0,38512031 1 1642 391 RHOG ras homolog family 0,32258711 7,125253266 0,0323796 0,38512031 member G 1643 253959 RALGAPA Ral GTPase activating -0,1024409 11,18318313 0,0323973 0,38512031 1 protein, alpha subunit 1 (catalytic) 1644 28992 MACROD MACRO domain containing -0,1450356 4,188985165 0,0324151 0,38512031 1 1 1645 55329 MNS1 meiosis-specific nuclear -0,2120709 5,808131104 0,0324152 0,38512031 structural 1 1646 6623 SNCG synuclein, gamma (breast 0,60798966 5,53726735 0,0324915 0,38556552 cancer-specific protein 1)

1647 3035 HARS histidyl-tRNA synthetase 0,08072628 9,389808383 0,0325075 0,38556552

1648 25923 ATL3 atlastin GTPase 3 0,09965715 6,830698159 0,0325119 0,38556552 1649 3301 DNAJA1 DnaJ (Hsp40) homolog, 0,16935811 10,34611724 0,0325469 0,38574647 subfamily A, member 1 1650 79651 RHBDF2 rhomboid 5 homolog 2 0,11336147 4,178245186 0,0326086 0,3860952 (Drosophila) 1651 283373 ANKRD52 ankyrin repeat domain 52 0,12015329 4,587940581 0,0326158 0,3860952

1652 6670 SP3 Sp3 transcription factor -0,0557542 7,59751313 0,0327233 0,38683435 1653 472 ATM ataxia telangiectasia 0,23041655 6,126576711 0,0327342 0,38683435 mutated 1654 6500 SKP1 S-phase kinase-associated 0,08063199 8,72046469 0,0327498 0,38683435 protein 1 1655 84947 SERAC1 serine active site 0,07757681 5,716590432 0,0327574 0,38683435 containing 1 1656 57580 PREX1 phosphatidylinositol-3,4,5- 0,20529739 4,993107094 0,0328168 0,38717077 trisphosphate-dependent Rac exchange factor 1

1657 54522 ANKRD16 ankyrin repeat domain 16 -0,0424603 3,130691215 0,0328266 0,38717077

1658 8625 RFXANK regulatory factor X- -0,2588359 6,678629786 0,0328727 0,38717077 associated ankyrin- containing protein 1659 9215 LARGE like-glycosyltransferase -0,0860698 2,241188446 0,0328966 0,38717077

1660 64718 UNKL unkempt family zinc finger- 0,07064235 5,970640722 0,0329246 0,38717077 like 1661 219844 HYLS1 hydrolethalus syndrome 1 0,28988048 3,99552838 0,0329462 0,38717077

1662 8065 CUL5 cullin 5 -0,0629172 8,951031068 0,0329525 0,38717077 1663 90321 ZNF766 zinc finger protein 766 -0,1518463 7,731211288 0,0329645 0,38717077 1664 151525 WDSUB1 WD repeat, sterile alpha -0,1730212 8,351108489 0,0329868 0,38717077 motif and U-box domain containing 1 1665 55034 MOCOS molybdenum cofactor -0,5958058 4,104548948 0,0329922 0,38717077 sulfurase 1666 396 ARHGDIA Rho GDP dissociation 0,09925393 5,540854594 0,0330475 0,38717077 inhibitor (GDI) alpha 1667 7371 UCK2 uridine-cytidine kinase 2 0,11740244 3,896770944 0,0330702 0,38717077

1668 3911 LAMA5 laminin, alpha 5 0,18575738 8,327380682 0,0330749 0,38717077 1669 5877 RABIF RAB interacting factor 0,24274518 5,273975838 0,0330829 0,38717077 1670 79759 ZNF668 zinc finger protein 668 0,01178959 2,230304749 0,0330831 0,38717077 1671 128439 SNHG11 small nucleolar RNA host -0,1804837 6,156139477 0,0331126 0,38724286 gene 11 (non-protein coding) 1672 119587 CPXM2 carboxypeptidase X (M14 0,27684797 6,886088197 0,0331736 0,38724286 family), member 2

1673 55824 PAG1 phosphoprotein associated 0,2354254 5,122966978 0,0331924 0,38724286 with glycosphingolipid microdomains 1

1674 84268 RPAIN RPA interacting protein -0,1129608 3,980694827 0,0331955 0,38724286 1675 27109 ATP5S ATP synthase, H+ -0,1431449 7,274992847 0,0332187 0,38724286 transporting, mitochondrial Fo complex, subunit s (factor B)

1676 55260 TMEM14 transmembrane protein -0,0875132 4,621410552 0,0332188 0,38724286 3 143 1677 5105 PCK1 phosphoenolpyruvate -0,7788024 11,63128613 0,0332279 0,38724286 carboxykinase 1 (soluble)

1678 81572 PDRG1 p53 and DNA-damage 0,08709894 7,385031142 0,0332659 0,38745409 regulated 1 1679 2799 GNS glucosamine (N-acetyl)-6- 0,14440361 11,53397495 0,0333067 0,38762976 sulfatase 1680 440574 MINOS1 mitochondrial inner 0,12343509 5,779943541 0,0333206 0,38762976 membrane organizing system 1 1681 2517 FUCA1 fucosidase, alpha-L- 1, 0,29384353 9,931350073 0,0333793 0,38801253 tissue 1682 6494 SIPA1 signal-induced 0,16861714 5,912942811 0,0333932 0,38801253 proliferation-associated 1

1683 55664 CDC37L1 cell division cycle 37-like 1 -0,2476467 9,811177982 0,0334798 0,38827319

1684 84148 KAT8 K(lysine) acetyltransferase -0,0274049 2,988290084 0,0334866 0,38827319 8 1685 55957 LIN37 lin-37 homolog (C. -0,1455252 7,698106747 0,0334957 0,38827319 elegans) 1686 256643 CXorf23 chromosome X open -0,1724365 7,140737472 0,0335051 0,38827319 reading frame 23 1687 125170 MIEF2 mitochondrial elongation -0,0152564 2,181291048 0,0335515 0,38827319 factor 2 1688 9909 DENND4 DENN/MADD domain 0,17475337 7,843695775 0,033571 0,38827319 B containing 4B 1689 185 AGTR1 angiotensin II receptor, -0,3488967 10,09030437 0,0335895 0,38827319 type 1 1690 3745 KCNB1 potassium voltage-gated 0,28545633 9,058737166 0,0335946 0,38827319 channel, Shab-related subfamily, member 1

1691 339742 FAM201 family with sequence -0,1624396 2,435543238 0,0336089 0,38827319 B similarity 201, member B

1692 2737 GLI3 GLI family zinc finger 3 -0,2357365 6,885522171 0,0336143 0,38827319 1693 151306 GPBAR1 G protein-coupled bile acid 0,33534625 6,521055508 0,0336602 0,38857383 receptor 1 1694 63916 ELMO2 engulfment and cell 0,17723461 5,889007152 0,033686 0,38857549 motility 2 1695 8892 EIF2B2 eukaryotic translation -0,1460196 8,085335816 0,0337157 0,38857549 initiation factor 2B, subunit 2 beta, 39kDa 1696 2932 GSK3B glycogen synthase kinase 3 -0,0523705 6,423995383 0,0337219 0,38857549 beta 1697 50507 NOX4 NADPH oxidase 4 0,71568142 6,272429706 0,0337399 0,38857549 1698 7965 AIMP2 aminoacyl tRNA 0,14743992 9,250116868 0,0337664 0,38865134 synthetase complex- interacting multifunctional protein 2

1699 57700 FAM160 family with sequence -0,0253303 5,684314493 0,033803 0,38884412 B1 similarity 160, member B1

1700 205327 C2orf69 chromosome 2 open 0,07197819 9,736924948 0,0338334 0,38896473 reading frame 69 1701 3656 IRAK2 interleukin-1 receptor- -0,2192905 4,292625354 0,0338848 0,38932607 associated kinase 2 1702 310 ANXA7 annexin A7 0,12017237 12,02038414 0,0339161 0,38945671 1703 79794 C12orf49 chromosome 12 open 0,07903805 5,008016101 0,0339673 0,38981223 reading frame 49 1704 27430 MAT2B methionine -0,0812466 10,7115467 0,0340189 0,38981223 adenosyltransferase II, beta 1705 8165 AKAP1 A kinase (PRKA) anchor -0,2383617 7,991003425 0,0340309 0,38981223 protein 1 1706 55379 LRRC59 leucine rich repeat 0,22366128 8,44040746 0,0340406 0,38981223 containing 59 1707 8648 NCOA1 nuclear receptor -0,0756797 8,338291717 0,0340467 0,38981223 coactivator 1 1708 10627 MYL12A myosin, light chain 12A, 0,08891766 13,0558583 0,0342784 0,39195718 regulatory, non-sarcomeric

1709 10111 RAD50 RAD50 homolog (S. -0,1135005 7,311770074 0,0342903 0,39195718 cerevisiae) 1710 22871 NLGN1 neuroligin 1 -0,3867886 6,002170392 0,0343035 0,39195718 1711 121642 ALKBH2 alkB, alkylation repair -0,1667866 5,590985174 0,0343286 0,39195718 homolog 2 (E. coli) 1712 50626 CYHR1 cysteine/histidine-rich 1 -0,1047689 6,496085741 0,0343344 0,39195718

1713 3309 HSPA5 heat shock 70kDa protein 0,25284832 7,515091244 0,0343546 0,39195911 5 (glucose-regulated protein, 78kDa)

1714 3021 H3F3B H3 histone, family 3B -0,1413315 11,18235278 0,0344331 0,39254791 (H3.3B) 1715 51429 SNX9 sorting nexin 9 -0,083423 9,774211902 0,0344699 0,39254791 1716 54927 CHCHD3 coiled-coil-helix-coiled-coil- -0,1475368 9,854864153 0,0344771 0,39254791 helix domain containing 3

1717 23710 GABARA GABA(A) receptor- -0,1883833 9,486436912 0,0344865 0,39254791 PL1 associated protein like 1

1718 6872 TAF1 TAF1 RNA polymerase II, -0,1707537 6,52947624 0,0345719 0,39297963 TATA box binding protein (TBP)-associated factor, 250kDa

1719 4698 NDUFA5 NADH dehydrogenase -0,128445 11,3336285 0,0345816 0,39297963 (ubiquinone) 1 alpha subcomplex, 5 1720 285381 DPH3 diphthamide biosynthesis 0,13872943 8,734565191 0,0346168 0,39297963 3 1721 60314 C12orf10 chromosome 12 open -0,1845486 7,282727007 0,034622 0,39297963 reading frame 10 1722 56180 MOSPD1 motile sperm domain -0,1823883 5,298054107 0,034625 0,39297963 containing 1 1723 2956 MSH6 mutS homolog 6 -0,1846494 6,396063502 0,0347099 0,39371423 1724 170082 TCEANC transcription elongation 0,32841225 2,85144073 0,0347852 0,39423905 factor A (SII) N-terminal and central domain containing 1725 2359 FPR3 formyl peptide receptor 3 0,48563051 4,81086288 0,0348244 0,39423905

1726 7251 TSG101 tumor susceptibility 101 -0,1070437 10,04795518 0,0348287 0,39423905

1727 8535 CBX4 chromobox homolog 4 0,11297062 2,805723347 0,0348368 0,39423905 1728 55666 NPLOC4 nuclear protein 0,16304266 8,69167258 0,0349547 0,39480758 localization 4 homolog (S. cerevisiae) 1729 1396 CRIP1 cysteine-rich protein 1 0,57289238 11,14471709 0,0349552 0,39480758 (intestinal) 1730 26262 TSPAN17 tetraspanin 17 0,22606081 5,504160217 0,0349671 0,39480758

1731 55796 MBNL3 muscleblind-like splicing 0,14740347 6,334837805 0,0349943 0,39480758 regulator 3 1732 404093 CUEDC1 CUE domain containing 1 0,10575585 5,124217109 0,0350311 0,39480758 1733 57621 ZBTB2 zinc finger and BTB domain -0,1349089 7,698195303 0,0350337 0,39480758 containing 2 1734 55322 C5orf22 chromosome 5 open -0,150464 5,02126379 0,035043 0,39480758 reading frame 22 1735 9019 MPZL1 myelin protein zero-like 1 0,05185316 6,472402827 0,0350487 0,39480758

1736 26053 AUTS2 autism susceptibility -0,1595617 3,976605263 0,0351561 0,39570812 candidate 2 1737 285095 LOC2850 uncharacterized -0,4203697 2,64542779 0,0351691 0,39570812 95 LOC285095 1738 220074 LRTOMT leucine rich -0,2587502 2,760674303 0,0352202 0,39603048 transmembrane and O- methyltransferase domain containing 1739 4047 LSS lanosterol synthase (2,3- -0,325719 6,449142069 0,0352553 0,39603048 oxidosqualene-lanosterol cyclase) 1740 55422 ZNF331 zinc finger protein 331 -0,1971459 6,225327213 0,0352585 0,39603048 1741 1468 SLC25A1 solute carrier family 25 -0,2551396 6,142231666 0,0353017 0,39628719 0 (mitochondrial carrier; dicarboxylate transporter), member 10

1742 9454 HOMER3 homer homolog 3 0,13801293 4,972286868 0,0353887 0,39703553 (Drosophila) 1743 4189 DNAJB9 DnaJ (Hsp40) homolog, -0,15155 8,570005462 0,0354213 0,39717361 subfamily B, member 9 1744 313 AOAH acyloxyacyl hydrolase 0,61962996 3,534138686 0,0354949 0,39742249 (neutrophil) 1745 23385 NCSTN nicastrin 0,1305319 7,123821795 0,0355081 0,39742249 1746 285 ANGPT2 angiopoietin 2 0,59038339 4,586128592 0,0355149 0,39742249 1747 7528 YY1 YY1 transcription factor -0,0483727 10,09001159 0,0355248 0,39742249 1748 7027 TFDP1 transcription factor Dp-1 0,15028391 8,702401655 0,0355687 0,39767102

1749 10197 PSME3 proteasome (prosome, 0,16221157 6,288805457 0,0355882 0,39767102 macropain) activator subunit 3 (PA28 gamma; Ki) 1750 80817 CEP44 centrosomal protein -0,0414676 7,151814867 0,0356081 0,39767102 44kDa 1751 9677 PPIP5K1 diphosphoinositol 0,15794454 2,891893989 0,0357329 0,39883701 pentakisphosphate kinase 1 1752 10253 SPRY2 sprouty homolog 2 -0,1881455 10,05432078 0,0358139 0,39912761 (Drosophila) 1753 1259 CNGA1 cyclic nucleotide gated -0,5022492 3,196755133 0,0358433 0,39912761 channel alpha 1 1754 23313 KIAA093 KIAA0930 0,42693316 6,944898426 0,0358594 0,39912761 0 1755 11056 DDX52 DEAD (Asp-Glu-Ala-Asp) -0,1204876 4,529820793 0,0358604 0,39912761 box polypeptide 52

1756 64210 MMS19 MMS19 nucleotide -0,1242417 7,713258214 0,0358706 0,39912761 excision repair homolog (S. cerevisiae) 1757 11068 CYB561D cytochrome b561 family, 0,12539698 7,17055258 0,0358815 0,39912761 2 member D2 1758 57181 SLC39A1 solute carrier family 39 0,16105823 9,112626186 0,0359569 0,39973893 0 (zinc transporter), member 10 1759 51374 ATRAID all-trans retinoic acid- -0,0830047 12,03109642 0,0360205 0,40021851 induced differentiation factor 1760 56910 STARD7 StAR-related lipid transfer 0,0769589 10,55509796 0,0360924 0,40078971 (START) domain containing 7 1761 27030 MLH3 mutL homolog 3 0,11824431 5,980913365 0,0361303 0,40097832 1762 124995 MRPL10 mitochondrial ribosomal -0,1394118 9,648452942 0,0361641 0,40097832 protein L10 1763 6428 SRSF3 serine/arginine-rich -0,156261 9,181101534 0,0361709 0,40097832 splicing factor 3 1764 23410 SIRT3 sirtuin 3 -0,05841 5,138051324 0,0362112 0,40119659 1765 57509 MTUS1 microtubule associated -0,2394556 8,948564174 0,0362767 0,40163481 tumor suppressor 1 1766 587 BCAT2 branched chain amino-acid -0,1768478 6,264635771 0,0362953 0,40163481 transaminase 2, mitochondrial 1767 1119 CHKA choline kinase alpha -0,3565236 6,059578382 0,0363151 0,40163481 1768 3601 IL15RA interleukin 15 receptor, -0,2292388 6,067281268 0,0363329 0,40163481 alpha 1769 54958 TMEM16 transmembrane protein 0,30604417 6,90994182 0,0363938 0,40201522 0 160 1770 51228 GLTP glycolipid transfer protein 0,10477093 8,53877392 0,0364379 0,40201522

1771 441549 CDNF cerebral dopamine -0,2811518 3,193959341 0,036438 0,40201522 neurotrophic factor 1772 25849 PARM1 prostate androgen- -0,2928487 7,869668343 0,0364524 0,40201522 regulated mucin-like protein 1 1773 1E+08 LOC1005 uncharacterized -0,0137987 2,194607922 0,0364845 0,40201522 06974 LOC100506974 1774 6390 SDHB succinate dehydrogenase -0,1794597 10,43243103 0,0365507 0,40201522 complex, subunit B, iron sulfur (Ip)

1775 5796 PTPRK protein tyrosine -0,1797542 9,37081658 0,0365512 0,40201522 phosphatase, receptor type, K 1776 348013 TMEM25 transmembrane protein 0,15603408 2,984696413 0,0365609 0,40201522 5B 255B 1777 51379 CRLF3 cytokine receptor-like 0,15341898 9,038955345 0,0365652 0,40201522 factor 3 1778 22931 RAB18 RAB18, member RAS -0,0911869 10,15781806 0,036573 0,40201522 oncogene family 1779 23595 ORC3 origin recognition -0,1522693 8,782390012 0,036599 0,40207414 complex, subunit 3 1780 3839 KPNA3 karyopherin alpha 3 0,16864832 9,201027359 0,0366925 0,4028758 (importin alpha 4) 1781 5451 POU2F1 POU class 2 homeobox 1 -0,0423473 3,210197538 0,0367222 0,40297481

1782 54976 C20orf27 chromosome 20 open -0,1744178 5,212592611 0,036753 0,40308651 reading frame 27 1783 169834 ZNF883 zinc finger protein 883 0,45988389 3,161924925 0,0367754 0,4031066 1784 5018 OXA1L oxidase (cytochrome c) -0,190467 9,991264759 0,0369026 0,40427402 assembly 1-like 1785 2926 GRSF1 G-rich RNA sequence -0,0729464 8,71738303 0,0369424 0,40448291 binding factor 1 1786 143503 OR51E1 olfactory receptor, family -0,7951842 5,810102413 0,0369825 0,40448657 51, subfamily E, member 1

1787 64978 MRPL38 mitochondrial ribosomal -0,1936088 3,883528107 0,0369841 0,40448657 protein L38 1788 51608 GET4 golgi to ER traffic protein 4 -0,1192204 4,653065342 0,0370228 0,4045124 homolog (S. cerevisiae)

1789 84102 SLC41A2 solute carrier family 41 0,2006405 3,865061359 0,0370456 0,4045124 (magnesium transporter), member 2 1790 150465 TTL tubulin tyrosine ligase 0,15863192 7,873815746 0,0370501 0,4045124 1791 92340 C17orf72 chromosome 17 open 0,05482274 2,397905211 0,0370693 0,4045124 reading frame 72 1792 83941 TM2D1 TM2 domain containing 1 -0,0998853 9,83263873 0,0371551 0,4052233

1793 79589 RNF128 ring finger protein 128, E3 -0,423162 2,607923777 0,0372013 0,40550049 ubiquitin protein ligase

1794 85463 ZC3H12C zinc finger CCCH-type -0,1937445 8,154714543 0,0372661 0,40598083 containing 12C 1795 57542 KLHL42 kelch-like family member 0,1286591 6,648068973 0,0373057 0,40618495 42 1796 2213 FCGR2B Fc fragment of IgG, low 0,50473207 8,548301181 0,0373282 0,40620347 affinity IIb, receptor (CD32) 1797 1536 CYBB cytochrome b-245, beta 0,61630766 7,200501408 0,0373761 0,40649915 polypeptide 1798 1628 DBP D site of albumin promoter -0,4356259 7,041333197 0,0374245 0,40671985 (albumin D-box) binding protein 1799 10428 CFDP1 craniofacial development -0,1195126 9,718816345 0,0374509 0,40671985 protein 1 1800 2734 GLG1 golgi glycoprotein 1 0,08431374 9,043506944 0,0374588 0,40671985 1801 119710 C11orf74 chromosome 11 open -0,1513147 7,878330351 0,0375291 0,40706541 reading frame 74 1802 79778 MICALL2 MICAL-like 2 0,35821926 4,566041284 0,0375435 0,40706541

1803 9556 C14orf2 chromosome 14 open -0,1113203 10,68018974 0,0375532 0,40706541 reading frame 2 1804 3005 H1F0 H1 histone family, -0,1540887 9,157400616 0,0376153 0,40751275 member 0 1805 259282 BOD1L1 biorientation of -0,1725576 7,619746245 0,0376818 0,40774372 chromosomes in cell division 1-like 1 1806 79871 RPAP2 RNA polymerase II -0,1006942 5,632744822 0,0377078 0,40774372 associated protein 2 1807 7347 UCHL3 ubiquitin carboxyl-terminal 0,19464187 9,363818477 0,037714 0,40774372 esterase L3 (ubiquitin thiolesterase)

1808 29935 RPA4 replication protein A4, 0,14803736 2,452345072 0,03772 0,40774372 30kDa 1809 119032 C10orf32 chromosome 10 open -0,1128335 11,02352697 0,0378226 0,40862664 reading frame 32 1810 8462 KLF11 Kruppel-like factor 11 -0,1025953 6,849226888 0,0379881 0,40983549 1811 83667 SESN2 sestrin 2 0,13937646 4,043773042 0,0379997 0,40983549 1812 800 CALD1 caldesmon 1 0,21003234 9,970857254 0,0380061 0,40983549 1813 57631 LRCH2 leucine-rich repeats and -0,2647493 6,170098761 0,0380184 0,40983549 calponin homology (CH) domain containing 2

1814 23623 RUSC1 RUN and SH3 domain 0,22360587 6,665946251 0,0380818 0,41015854 containing 1 1815 57488 ESYT2 extended synaptotagmin- 0,07676519 8,726221098 0,0380903 0,41015854 like protein 2

1816 340277 FAM221 family with sequence -0,308319 6,961124377 0,0381587 0,41066787 A similarity 221, member A

1817 58493 INIP INTS3 and NABP 0,11230675 8,616456684 0,0382007 0,41068275 interacting protein 1818 5211 PFKL phosphofructokinase, liver -0,079736 6,174779319 0,0382021 0,41068275

1819 56034 PDGFC platelet derived growth -0,1035274 10,89459531 0,0382855 0,41135306 factor C 1820 3055 HCK hemopoietic cell kinase 0,7313626 6,066869973 0,0383129 0,41142142

1821 26190 FBXW2 F-box and WD repeat 0,03773212 7,562014063 0,0383365 0,41144879 domain containing 2 1822 81545 FBXO38 F-box protein 38 -0,0424317 7,743668927 0,0383616 0,41148153 1823 169200 TMEM64 transmembrane protein 64 0,2370256 8,935228598 0,0383816 0,41148153

1824 1524 CX3CR1 chemokine (C-X3-C motif) 0,81617647 6,452961228 0,038463 0,41212729 receptor 1 1825 9734 HDAC9 histone deacetylase 9 -0,1872002 4,267134026 0,0384854 0,41214217 1826 10346 TRIM22 tripartite motif containing 0,23193821 10,72269076 0,0385494 0,4121592 22 1827 6322 SCML1 sex comb on midleg-like 1 -0,2289472 7,727182824 0,0385606 0,4121592 (Drosophila) 1828 10039 PARP3 poly (ADP-ribose) 0,1296409 3,583384588 0,038568 0,4121592 polymerase family, member 3 1829 10285 SMNDC1 survival motor neuron -0,0961669 10,8153282 0,0385714 0,4121592 domain containing 1 1830 375189 PFN4 profilin family, member 4 -0,0498125 2,347584016 0,0386314 0,41257476

1831 6224 RPS20 ribosomal protein S20 -0,107639 14,00278517 0,0386558 0,41261047 1832 4905 NSF N-ethylmaleimide- 0,16857836 8,834653362 0,0387139 0,41283159 sensitive factor 1833 2247 FGF2 fibroblast growth factor 2 -0,3241178 8,514852193 0,0387326 0,41283159 (basic) 1834 54148 MRPL39 mitochondrial ribosomal -0,1803812 8,082514671 0,0387399 0,41283159 protein L39 1835 6205 RPS11 ribosomal protein S11 -0,0551464 15,48493695 0,0387829 0,41306461 1836 7162 TPBG trophoblast glycoprotein 0,29427917 8,369149278 0,038882 0,41387906

1837 6717 SRI sorcin -0,0751074 10,3818578 0,0389018 0,41387906 1838 403341 ZBTB34 zinc finger and BTB domain -0,1596607 7,833915546 0,0389293 0,41391777 containing 34 1839 51177 PLEKHO1 pleckstrin homology 0,36661127 7,001244458 0,0389477 0,41391777 domain containing, family O member 1 1840 55146 ZDHHC4 zinc finger, DHHC-type -0,1611394 8,782644965 0,039026 0,41447664 containing 4 1841 51304 ZDHHC3 zinc finger, DHHC-type 0,10670951 6,659327246 0,0390446 0,41447664 containing 3 1842 84532 ACSS1 acyl-CoA synthetase short- 0,07904172 2,471192379 0,0390785 0,41447664 chain family member 1

1843 27106 ARRDC2 arrestin domain containing 0,22390172 7,123803718 0,0391026 0,41447664 2 1844 55149 MTPAP mitochondrial poly(A) -0,1317954 8,294352522 0,0391808 0,41447664 polymerase 1845 53944 CSNK1G1 casein kinase 1, gamma 1 0,02476802 5,141552304 0,0391834 0,41447664

1846 4282 MIF macrophage migration 0,18947459 9,990847181 0,0391986 0,41447664 inhibitory factor (glycosylation-inhibiting factor) 1847 4706 NDUFAB NADH dehydrogenase -0,0988757 12,4627397 0,0391989 0,41447664 1 (ubiquinone) 1, alpha/beta subcomplex, 1, 8kDa

1848 7879 RAB7A RAB7A, member RAS 0,09318211 10,5264558 0,0392633 0,41447664 oncogene family 1849 124935 SLC43A2 solute carrier family 43 0,12965935 5,434731661 0,039285 0,41447664 (amino acid system L transporter), member 2 1850 56954 NIT2 nitrilase family, member 2 -0,1435716 10,33496123 0,0392872 0,41447664

1851 93109 TMEM44 transmembrane protein 44 0,25847002 3,605978715 0,039304 0,41447664

1852 26260 FBXO25 F-box protein 25 -0,1319751 8,478724686 0,039359 0,41447664 1853 28956 LAMTOR late endosomal/lysosomal 0,14268618 9,16146013 0,0393676 0,41447664 2 adaptor, MAPK and MTOR activator 2

1854 9663 LPIN2 lipin 2 -0,1599361 6,691126451 0,0393841 0,41447664 1855 23080 AVL9 AVL9 homolog (S. -0,061357 3,590975081 0,0393882 0,41447664 cerevisiase) 1856 4683 NBN nibrin -0,1220473 9,754536199 0,0393963 0,41447664 1857 51111 SUV420H suppressor of variegation -0,1068665 8,223736923 0,0394269 0,41447664 1 4-20 homolog 1 (Drosophila) 1858 10728 PTGES3 prostaglandin E synthase 3 -0,0875798 12,78093753 0,0394279 0,41447664 (cytosolic) 1859 280636 C11orf31 chromosome 11 open -0,0844886 10,40778294 0,0394391 0,41447664 reading frame 31 1860 4710 NDUFB4 NADH dehydrogenase -0,0906546 6,061410448 0,0394457 0,41447664 (ubiquinone) 1 beta subcomplex, 4, 15kDa 1861 1992 SERPINB serpin peptidase inhibitor, 0,20153796 8,754821804 0,0394869 0,41468724 1 clade B (ovalbumin), member 1 1862 147179 WIPF2 WAS/WASL interacting 0,09712229 7,880462525 0,0396118 0,41556354 protein family, member 2

1863 360205 PRAC2 prostate cancer 0,08309212 2,881215065 0,0396129 0,41556354 susceptibility candidate 2

1864 55374 TMCO6 transmembrane and coiled- -0,2999471 4,622914378 0,0396762 0,41598284 coil domains 6 1865 5134 PDCD2 programmed cell death 2 -0,0991282 7,253645658 0,0396955 0,41598284

1866 23609 MKRN2 makorin ring finger protein -0,0823907 6,7547005 0,0397196 0,41601286 2 1867 3304 HSPA1B heat shock 70kDa protein 0,21926865 9,281956583 0,0397913 0,41654013 1B 1868 54221 SNTG2 syntrophin, gamma 2 -0,1391442 2,993066155 0,0398373 0,41663466 1869 23177 CEP68 centrosomal protein -0,1005147 9,18544291 0,0398429 0,41663466 68kDa 1870 10040 TOM1L1 target of myb1 (chicken)- -0,2060904 7,897756806 0,0398992 0,41700028 like 1 1871 3683 ITGAL integrin, alpha L (antigen 0,2438498 3,447627132 0,0399273 0,41707017 CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide) 1872 92400 RBM18 RNA binding motif protein -0,1222487 7,590198111 0,0399673 0,41726575 18 1873 84105 PCBD2 pterin-4 alpha- -0,183911 5,391126144 0,0400011 0,41739486 carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha (TCF1) 2 1874 55681 SCYL2 SCY1-like 2 (S. cerevisiae) 0,08897908 9,175586852 0,0400709 0,41767954

1875 196513 DCP1B decapping mRNA 1B -0,1001354 8,54535563 0,0400711 0,41767954 1876 54623 PAF1 Paf1, RNA polymerase II 0,10385404 7,962757882 0,0401011 0,4177692 associated factor, homolog (S. cerevisiae) 1877 5214 PFKP phosphofructokinase, 0,26066355 6,792536288 0,0401668 0,41823124 platelet 1878 55332 DRAM1 DNA-damage regulated 0,30790704 7,710744846 0,0402034 0,41838986 autophagy modulator 1 1879 11162 NUDT6 nudix (nucleoside -0,1869701 7,567792429 0,0402828 0,41867116 diphosphate linked moiety X)-type motif 6 1880 8347 HIST1H2 histone cluster 1, H2bc 0,44809578 3,776379477 0,0402918 0,41867116 BC 1881 22838 RNF44 ring finger protein 44 0,17641262 7,240518885 0,0403023 0,41867116 1882 345757 FAM174 family with sequence -0,131103 10,34034299 0,0403333 0,41867116 A similarity 174, member A

1883 3092 HIP1 huntingtin interacting 0,11208541 7,598641316 0,0403458 0,41867116 protein 1 1884 132949 AASDH aminoadipate- 0,06029214 7,479630211 0,04038 0,41867116 semialdehyde dehydrogenase 1885 85458 DIXDC1 DIX domain containing 1 0,09143367 7,004179599 0,0403804 0,41867116

1886 1E+08 RP11- uncharacterized -0,1736226 7,473608904 0,040518 0,41987456 620J15.3 LOC100506844 1887 81931 ZNF93 zinc finger protein 93 -0,0955272 3,832589199 0,0406328 0,42027662 1888 402682 UFSP1 UFM1-specific peptidase 1 0,16590178 2,714473398 0,0406379 0,42027662 (non-functional) 1889 10049 DNAJB6 DnaJ (Hsp40) homolog, 0,13335485 9,373311928 0,0406379 0,42027662 subfamily B, member 6 1890 125058 TBC1D16 TBC1 domain family, 0,08231697 6,187521824 0,0406428 0,42027662 member 16 1891 57511 COG6 component of oligomeric -0,057818 6,072092027 0,0406788 0,42042642 golgi complex 6

1892 1780 DYNC1I1 dynein, cytoplasmic 1, 0,11391931 2,402167043 0,0407464 0,42090281 intermediate chain 1 1893 4291 MLF1 myeloid leukemia factor 1 -0,2060652 6,016960613 0,0408082 0,42127605

1894 11180 WDR6 WD repeat domain 6 0,06383126 2,264499385 0,0408379 0,42127605 1895 4628 MYH10 myosin, heavy chain 10, -0,1871539 10,13373796 0,0408585 0,42127605 non-muscle 1896 255031 LINC0095 long intergenic non- 0,24760917 6,704568231 0,0408843 0,42127605 7 protein coding RNA 957 1897 57763 ANKRA2 ankyrin repeat, family A -0,1176446 9,37685689 0,0408903 0,42127605 (RFXANK-like), 2 1898 140739 UBE2F ubiquitin-conjugating 0,10375157 8,537712179 0,0409278 0,42144015 enzyme E2F (putative) 1899 130617 ZFAND2B zinc finger, AN1-type 0,25821472 6,970426059 0,0409913 0,42187197 domain 2B 1900 1386 ATF2 activating transcription -0,0947652 6,241955054 0,0410852 0,42261531 factor 2 1901 10954 PDIA5 protein disulfide 0,28983605 7,383208055 0,0411088 0,42263614 isomerase family A, member 5 1902 3708 ITPR1 inositol 1,4,5- -0,2191539 8,099090451 0,0412362 0,42325494 trisphosphate receptor, type 1 1903 130132 RFTN2 raftlin family member 2 -0,138893 4,10063499 0,0412443 0,42325494 1904 23116 FAM179 family with sequence -0,0969541 9,420272768 0,0412626 0,42325494 B similarity 179, member B

1905 344405 PRORSD1 prolyl-tRNA synthetase -0,3218346 2,751315839 0,0412731 0,42325494 P associated domain containing 1, pseudogene

1906 90933 TRIM41 tripartite motif containing 0,19558607 7,254950055 0,0412773 0,42325494 41 1907 6184 RPN1 ribophorin I 0,13926788 10,56447328 0,0413714 0,42398726 1908 65082 VPS33A vacuolar protein sorting 33 -0,0981646 7,189098231 0,0413921 0,42398726 homolog A (S. cerevisiae)

1909 84302 TMEM24 transmembrane protein 0,2789674 5,604095561 0,0414924 0,4246859 6 246 1910 25825 BACE2 beta-site APP-cleaving 0,25785797 7,423134233 0,0415104 0,4246859 enzyme 2 1911 4048 LTA4H leukotriene A4 hydrolase -0,1377177 10,65183599 0,0415255 0,4246859 1912 388125 C2CD4B C2 calcium-dependent 0,05026425 3,775471455 0,0415723 0,42494187 domain containing 4B 1913 3512 IGJ immunoglobulin J 0,73486482 7,261434475 0,0416103 0,42510826 polypeptide, linker protein for immunoglobulin alpha and mu polypeptides

1914 8334 HIST1H2 histone cluster 1, H2ac 0,40115899 8,954172601 0,0416497 0,4252403 AC 1915 7110 TMF1 TATA element modulatory -0,0891127 8,31830134 0,0416871 0,4252403 factor 1 1916 6347 CCL2 chemokine (C-C motif) 0,66562353 7,210033423 0,0416885 0,4252403 ligand 2 1917 8820 HESX1 HESX homeobox 1 -0,0121914 2,179857743 0,0417809 0,42596027 1918 56605 ERO1LB ERO1-like beta (S. -0,1462479 6,434585649 0,0418557 0,42647564 cerevisiae) 1919 51647 FAM96B family with sequence -0,109858 9,607531435 0,0418806 0,42647564 similarity 96, member B 1920 220002 CYB561A cytochrome b561 family, 0,29034881 7,996287563 0,0418969 0,42647564 3 member A3 1921 56131 PCDHB4 protocadherin beta 4 -0,0963347 2,584572651 0,0419191 0,42647957 1922 501 ALDH7A1 aldehyde dehydrogenase 7 -0,1343221 7,533929215 0,0419539 0,42654387 family, member A1

1923 9805 SCRN1 secernin 1 0,25483939 8,584799778 0,0419902 0,42654387 1924 1763 DNA2 DNA replication -0,366369 3,093637592 0,0419909 0,42654387 helicase/nuclease 2 1925 83888 FGFBP2 fibroblast growth factor -0,6964438 6,52932668 0,0420532 0,42695452 binding protein 2 1926 11198 SUPT16H suppressor of Ty 16 -0,0723025 4,045444576 0,0420971 0,42704591 homolog (S. cerevisiae) 1927 10199 MPHOSP M-phase phosphoprotein -0,1006175 9,007821929 0,0421236 0,42704591 H10 10 (U3 small nucleolar ribonucleoprotein)

1928 5106 PCK2 phosphoenolpyruvate -0,3245258 7,880434417 0,0421277 0,42704591 carboxykinase 2 (mitochondrial) 1929 10651 MTX2 metaxin 2 -0,0888124 9,574011722 0,0422356 0,42762993 1930 79709 COLGALT collagen beta(1- 0,07256693 5,443329473 0,0422446 0,42762993 1 O)galactosyltransferase 1

1931 3475 IFRD1 interferon-related -0,1944431 9,381156582 0,042251 0,42762993 developmental regulator 1

1932 84811 BUD13 BUD13 homolog (S. -0,1549423 6,707998899 0,0422929 0,42783223 cerevisiae) 1933 64784 CRTC3 CREB regulated -0,207721 10,48270883 0,0423749 0,42825831 transcription coactivator 3 1934 4799 NFX1 nuclear transcription -0,0959359 4,557236419 0,0423788 0,42825831 factor, X-box binding 1 1935 652 BMP4 bone morphogenetic 0,22847074 4,207178028 0,0424167 0,42841972 protein 4 1936 57150 SMIM8 small integral membrane -0,114012 4,789067337 0,0425325 0,42936707 protein 8 1937 6655 SOS2 son of sevenless homolog -0,0897172 4,882430881 0,0425793 0,42937203 2 (Drosophila) 1938 4172 MCM3 minichromosome 0,08282466 8,531159806 0,0425897 0,42937203 maintenance complex component 3 1939 1E+08 FGD5- FGD5 antisense RNA 1 0,13054725 11,90382643 0,0425989 0,42937203 AS1 1940 6310 ATXN1 ataxin 1 -0,1964658 8,691283083 0,0426245 0,42940902 1941 7073 TIAL1 TIA1 cytotoxic granule- -0,0500939 6,829144867 0,0427115 0,42978276 associated RNA binding protein-like 1 1942 5910 RAP1GDS RAP1, GTP-GDP -0,1417737 7,827755711 0,0427306 0,42978276 1 dissociation stimulator 1

1943 7095 SEC62 SEC62 homolog (S. 0,09878826 10,63058038 0,0427343 0,42978276 cerevisiae) 1944 1759 DNM1 dynamin 1 0,56979055 6,291518299 0,0427496 0,42978276 1945 54870 QRICH1 glutamine-rich 1 0,07325865 8,327168684 0,0427822 0,42989004 1946 4520 MTF1 metal-regulatory 0,09048988 5,971726916 0,0429015 0,43040826 transcription factor 1 1947 3588 IL10RB interleukin 10 receptor, 0,10379337 8,979322293 0,0429029 0,43040826 beta 1948 10287 RGS19 regulator of G-protein 0,20680264 7,0969821 0,0429095 0,43040826 signaling 19 1949 6429 SRSF4 serine/arginine-rich -0,1506458 10,41747235 0,0429219 0,43040826 splicing factor 4 1950 9079 LDB2 LIM domain binding 2 -0,2274871 11,19114745 0,0429609 0,43041432 1951 4603 MYBL1 v-myb avian 0,14479989 3,146066451 0,0429666 0,43041432 myeloblastosis viral oncogene homolog-like 1

1952 23326 USP22 ubiquitin specific 0,05693605 9,939016216 0,0430117 0,43063919 peptidase 22 1953 8705 B3GALT4 UDP-Gal:betaGlcNAc beta 0,16187388 6,621074013 0,0430512 0,43063919 1,3-galactosyltransferase, polypeptide 4

1954 6769 STAC SH3 and cysteine rich -0,1758527 2,365192092 0,0430681 0,43063919 domain 1955 6398 SECTM1 secreted and 0,27712061 3,87289459 0,0430771 0,43063919 transmembrane 1 1956 388 RHOB ras homolog family -0,2180491 3,912200531 0,0431865 0,43133778 member B 1957 643733 LOC6437 caspase 4, apoptosis- 0,24982514 8,328514655 0,0431938 0,43133778 33 related cysteine peptidase pseudogene 1958 817 CAMK2D calcium/calmodulin- -0,1412873 8,795878865 0,0432366 0,43133778 dependent protein kinase II delta 1959 1471 CST3 cystatin C 0,16545043 9,24652245 0,0432639 0,43133778 1960 7133 TNFRSF1 tumor necrosis factor 0,21067863 8,84165077 0,0432704 0,43133778 B receptor superfamily, member 1B 1961 258010 SVIP small VCP/p97-interacting -0,1693224 8,374258624 0,0432794 0,43133778 protein 1962 6894 TARBP1 TAR (HIV-1) RNA binding 0,1433424 7,822249152 0,0433891 0,43184187 protein 1 1963 6424 SFRP4 secreted frizzled-related 0,77761577 9,123353389 0,0433941 0,43184187 protein 4 1964 4881 NPR1 natriuretic peptide -0,1990006 8,676141067 0,0433963 0,43184187 receptor 1 1965 5281 PIGF phosphatidylinositol 0,17661887 8,054204919 0,0434635 0,43229003 glycan anchor biosynthesis, class F 1966 134728 IRAK1BP interleukin-1 receptor- -0,5479881 4,199625578 0,0435137 0,43256987 1 associated kinase 1 binding protein 1 1967 8613 PPAP2B phosphatidic acid -0,2812268 10,8432521 0,0435592 0,43260771 phosphatase type 2B 1968 904 CCNT1 cyclin T1 -0,1304304 7,619151302 0,0435618 0,43260771 1969 10344 CCL26 chemokine (C-C motif) -0,0258999 2,197500402 0,0436277 0,43304195 ligand 26 1970 51227 PIGP phosphatidylinositol -0,1804219 11,31322642 0,0436756 0,43324543 glycan anchor biosynthesis, class P 1971 11316 COPE coatomer protein 0,23205787 7,40375571 0,0436999 0,43324543 complex, subunit epsilon

1972 84674 CARD6 caspase recruitment 0,20771558 8,947853588 0,0437147 0,43324543 domain family, member 6

1973 11213 IRAK3 interleukin-1 receptor- -0,1635096 4,823372137 0,0437444 0,4333199 associated kinase 3 1974 670 BPHL biphenyl hydrolase-like -0,2457763 9,080107584 0,043778 0,43343348 (serine hydrolase) 1975 10062 NR1H3 nuclear receptor subfamily -0,1479438 8,934969661 0,043805 0,43348113 1, group H, member 3

1976 1894 ECT2 epithelial cell transforming 0,23570428 6,282706936 0,0438291 0,4334996 2 1977 3597 IL13RA1 interleukin 13 receptor, -0,2124344 8,118994442 0,0438862 0,43384559 alpha 1 1978 10171 RCL1 RNA terminal phosphate -0,3220801 7,758213267 0,0439595 0,43434964 cyclase-like 1

1979 60489 APOBEC3 apolipoprotein B mRNA 0,31383674 7,439348091 0,0440058 0,43444173 G editing enzyme, catalytic polypeptide-like 3G

1980 63875 MRPL17 mitochondrial ribosomal 0,11458968 8,780791522 0,0440132 0,43444173 protein L17 1981 4942 OAT ornithine 0,13589502 12,21132087 0,0440543 0,43462806 aminotransferase 1982 4141 MARS methionyl-tRNA 0,15771927 8,887458081 0,0441032 0,43489078 synthetase 1983 79892 MCMBP minichromosome -0,0811835 8,655113971 0,044147 0,43510333 maintenance complex binding protein 1984 27128 CYTH4 cytohesin 4 0,08441122 2,645382813 0,0442206 0,43560858 1985 2769 GNA15 guanine nucleotide binding 0,29317834 5,303575615 0,0442469 0,43564812 protein (G protein), alpha 15 (Gq class)

1986 54868 TMEM10 transmembrane protein 0,20544965 4,4021206 0,0443136 0,43608506 4 104 1987 5911 RAP2A RAP2A, member of RAS 0,19791165 8,858353566 0,0443695 0,43609471 oncogene family 1988 25957 PNISR PNN-interacting -0,1145188 10,31583477 0,0443786 0,43609471 serine/arginine-rich protein 1989 64112 MOAP1 modulator of apoptosis 1 -0,1181137 10,53790321 0,0443815 0,43609471

1990 7375 USP4 ubiquitin specific 0,0756147 9,22705346 0,0445178 0,43645664 peptidase 4 (proto- oncogene) 1991 1E+08 LINC0118 long intergenic non- 0,27053505 2,581224614 0,0445195 0,43645664 6 protein coding RNA 1186

1992 25845 PP7080 uncharacterized LOC25845 -0,1924343 5,215151967 0,04453 0,43645664

1993 1E+08 LOC1019 uncharacterized 0,66931764 5,150847002 0,0445404 0,43645664 29398 LOC101929398 1994 3836 KPNA1 karyopherin alpha 1 0,12062122 7,508802232 0,0445467 0,43645664 (importin alpha 5) 1995 6119 RPA3 replication protein A3, -0,1518433 9,506698981 0,0445523 0,43645664 14kDa 1996 199 AIF1 allograft inflammatory 0,46109028 7,392503246 0,044596 0,43666543 factor 1 1997 64135 IFIH1 interferon induced with 0,2353696 8,516443597 0,0446385 0,43686293 helicase C domain 1 1998 25885 POLR1A polymerase (RNA) I 0,08416755 2,739029182 0,0447365 0,43760271 polypeptide A, 194kDa 1999 5707 PSMD1 proteasome (prosome, 0,17553679 9,9886534 0,0448716 0,43870425 macropain) 26S subunit, non-ATPase, 1 2000 5465 PPARA peroxisome proliferator- -0,1807354 4,582900953 0,0449697 0,43895382 activated receptor alpha

2001 51542 VPS54 vacuolar protein sorting 54 -0,0904086 8,977189351 0,0449914 0,43895382 homolog (S. cerevisiae)

2002 24146 CLDN15 claudin 15 0,10982987 6,850889344 0,0449925 0,43895382 2003 3838 KPNA2 karyopherin alpha 2 (RAG 0,40174036 10,81735499 0,0450093 0,43895382 cohort 1, importin alpha 1)

2004 317761 C14orf39 chromosome 14 open -0,2906828 2,535263222 0,0450594 0,43895382 reading frame 39 2005 3093 UBE2K ubiquitin-conjugating 0,12857691 9,162738785 0,0450635 0,43895382 enzyme E2K 2006 84266 ALKBH7 alkB, alkylation repair -0,0703505 7,375542309 0,0450746 0,43895382 homolog 7 (E. coli) 2007 4234 METTL1 methyltransferase like 1 0,29308435 2,853638898 0,0450768 0,43895382

2008 9659 PDE4DIP phosphodiesterase 4D 0,15653688 3,909919169 0,0451725 0,43966734 interacting protein 2009 55852 TEX2 testis expressed 2 0,15775219 9,333436213 0,0453067 0,44075368 2010 57447 NDRG2 NDRG family member 2 0,21098293 7,858756267 0,0453534 0,44080731 2011 10109 ARPC2 actin related protein 2/3 0,14244252 12,54003904 0,0453573 0,44080731 complex, subunit 2, 34kDa

2012 400258 C14orf18 chromosome 14 open -0,3383321 9,306505753 0,0454065 0,44106544 0 reading frame 180 2013 9506 PAGE4 P antigen family, member -0,1070227 2,485230604 0,0454981 0,44157462 4 (prostate associated)

2014 54434 SSH1 slingshot protein 0,02961775 2,450197337 0,0455188 0,44157462 phosphatase 1 2015 552889 ATXN7L3 ataxin 7-like 3B -0,0690929 7,655391246 0,0455301 0,44157462 B 2016 79148 MMP28 matrix metallopeptidase 0,21055949 7,175635087 0,0455517 0,44157462 28 2017 23354 HAUS5 HAUS augmin-like 0,08944523 3,399892554 0,0455718 0,44157462 complex, subunit 5 2018 388115 C15orf52 chromosome 15 open 0,14521981 2,904569789 0,0456262 0,44188221 reading frame 52 2019 23300 ATMIN ATM interactor -0,0710184 9,769927054 0,0456559 0,44195093 2020 55291 PPP6R3 protein phosphatase 6, -0,0620124 9,512325279 0,0456976 0,44197413 regulatory subunit 3 2021 55787 TXLNG taxilin gamma -0,1555297 6,830319741 0,0457035 0,44197413 2022 51586 MED15 mediator complex subunit 0,09031117 6,659086581 0,0457333 0,44204287 15 2023 51280 GOLM1 golgi membrane protein 1 0,23715809 7,028747858 0,0458123 0,44258849

2024 22938 SNW1 SNW domain containing 1 -0,0575941 10,2851378 0,0458363 0,44260097

2025 118924 FRA10AC fragile site, folic acid type, -0,1039876 7,092097522 0,0459349 0,44310772 1 rare, fra(10)(q23.3) or fra(10)(q24.2) candidate 1

2026 8863 PER3 period circadian clock 3 -0,1329173 5,588721594 0,0459409 0,44310772 2027 57722 IGDCC4 immunoglobulin -0,653064 6,952816656 0,045965 0,44310772 superfamily, DCC subclass, member 4 2028 140461 ASB8 ankyrin repeat and SOCS -0,0657297 8,830979032 0,0460078 0,44310772 box containing 8 2029 84171 LOXL4 lysyl oxidase-like 4 0,34136882 6,548112447 0,0460263 0,44310772 2030 60491 NIF3L1 NIF3 NGG1 interacting 0,0852846 9,244306987 0,0460349 0,44310772 factor 3-like 1 (S. cerevisiae) 2031 29979 UBQLN1 ubiquilin 1 -0,0835617 8,911674234 0,0460475 0,44310772 2032 51306 FAM13B family with sequence 0,10570854 9,272900876 0,0461168 0,44355618 similarity 13, member B 2033 2665 GDI2 GDP dissociation inhibitor -0,0707888 12,16030717 0,0461866 0,44381687 2 2034 222068 TMED4 transmembrane emp24 -0,0863845 8,393626755 0,0461893 0,44381687 protein transport domain containing 4 2035 55248 TMEM20 transmembrane protein 0,57730237 5,310558466 0,0463397 0,44504377 6 206 2036 57449 PLEKHG5 pleckstrin homology 0,27589511 4,578359346 0,0464377 0,4457657 domain containing, family G (with RhoGef domain) member 5 2037 8804 CREG1 cellular repressor of E1A- 0,10091917 12,5031263 0,0464831 0,44598207 stimulated genes 1 2038 10778 ZNF271 zinc finger protein 271 0,09876802 6,546438201 0,046523 0,44610589 2039 27071 DAPP1 dual adaptor of 0,32003914 2,480249156 0,046545 0,44610589 phosphotyrosine and 3- phosphoinositides 2040 257218 SHPRH SNF2 histone linker PHD -0,1392344 8,932936855 0,0465645 0,44610589 RING helicase, E3 ubiquitin protein ligase 2041 140609 NEK7 NIMA-related kinase 7 0,13181771 13,56764625 0,0466005 0,44623277 2042 4707 NDUFB1 NADH dehydrogenase -0,080477 13,20284371 0,0466517 0,44650355 (ubiquinone) 1 beta subcomplex, 1, 7kDa 2043 3145 HMBS hydroxymethylbilane 0,27870722 6,349236886 0,0467262 0,44699784 synthase 2044 58487 CREBZF CREB/ATF bZIP -0,1128261 7,412940727 0,0468544 0,44800498 transcription factor 2045 6879 TAF7 TAF7 RNA polymerase II, -0,0636631 10,61517888 0,0469119 0,44833562 TATA box binding protein (TBP)-associated factor, 55kDa

2046 3394 IRF8 interferon regulatory 0,27261709 9,12154935 0,0469489 0,44845852 factor 8 2047 51274 KLF3 Kruppel-like factor 3 -0,1343575 6,643122723 0,0469781 0,44845852 (basic) 2048 90784 LOC9078 uncharacterized LOC90784 0,16456803 2,622827872 0,0469936 0,44845852 4 2049 338799 LINC0108 long intergenic non- 0,17984136 4,129247617 0,0470639 0,44891029 9 protein coding RNA 1089

2050 5686 PSMA5 proteasome (prosome, 0,13382676 6,185437224 0,0471284 0,44921258 macropain) subunit, alpha type, 5 2051 51088 KLHL5 kelch-like family member 5 0,18118369 9,164495979 0,0471708 0,44921258

2052 1794 DOCK2 dedicator of cytokinesis 2 0,54614126 6,663816276 0,0471803 0,44921258

2053 11021 RAB35 RAB35, member RAS 0,04514942 2,996589087 0,0471875 0,44921258 oncogene family 2054 50814 NSDHL NAD(P) dependent steroid -0,1552833 7,453149313 0,047247 0,44928107 dehydrogenase-like

2055 9509 ADAMTS ADAM metallopeptidase 0,16953826 7,137490371 0,0472557 0,44928107 2 with thrombospondin type 1 motif, 2

2056 116535 MRGPRF MAS-related GPR, member 0,32670052 8,594745176 0,0472637 0,44928107 F 2057 9743 ARHGAP Rho GTPase activating -0,3301804 5,193904522 0,0473357 0,44955779 32 protein 32 2058 8825 LIN7A lin-7 homolog A (C. -0,2729492 2,31177155 0,0473658 0,44955779 elegans) 2059 51131 PHF11 PHD finger protein 11 0,14216229 10,70791666 0,0473707 0,44955779 2060 4927 NUP88 nucleoporin 88kDa -0,0903039 9,393491529 0,0473976 0,44955779 2061 240 ALOX5 arachidonate 5- 0,14368664 4,064301256 0,0474096 0,44955779 lipoxygenase 2062 1073 CFL2 cofilin 2 (muscle) -0,1238077 10,50990971 0,0474308 0,44955779 2063 6903 TBCC tubulin folding cofactor C -0,0773232 8,357513708 0,0475258 0,45022453

2064 9114 ATP6V0D ATPase, H+ transporting, 0,14395001 9,796820472 0,0475472 0,45022453 1 lysosomal 38kDa, V0 subunit d1 2065 63894 VIPAS39 VPS33B interacting -0,0411982 2,666499214 0,0475958 0,45046565 protein, apical-basolateral polarity regulator, spe-39 homolog

2066 768211 RELL1 RELT-like 1 0,06360696 2,935504719 0,0476329 0,45059877 2067 440434 LOC4404 aminopeptidase -0,1414106 8,246826901 0,047688 0,45065515 34 puromycin sensitive pseudogene 2068 64167 ERAP2 endoplasmic reticulum 0,11869303 6,716306786 0,0477054 0,45065515 aminopeptidase 2 2069 8992 ATP6V0E ATPase, H+ transporting, 0,07253612 12,49994106 0,047708 0,45065515 1 lysosomal 9kDa, V0 subunit e1 2070 10175 CNIH1 cornichon family AMPA -0,0532702 10,7844979 0,0477693 0,45081187 receptor auxiliary protein 1 2071 376412 RNF126P ring finger protein 126 -0,1435492 2,47735102 0,0477707 0,45081187 1 pseudogene 1 2072 23071 ERP44 endoplasmic reticulum -0,0613866 6,698407444 0,0478124 0,45098715 protein 44 2073 25976 TIPARP TCDD-inducible poly(ADP- -0,245291 8,411925911 0,0478676 0,4512903 ribose) polymerase

2074 79639 TMEM53 transmembrane protein 53 -0,0698469 5,01063417 0,0479062 0,45143627

2075 7461 CLIP2 CAP-GLY domain 0,28598344 2,677374546 0,0479454 0,45151626 containing linker protein 2

2076 57120 GOPC golgi-associated PDZ and -0,0546816 6,219272712 0,0479609 0,45151626 coiled-coil motif containing 2077 253190 SERHL2 serine hydrolase-like 2 0,36459704 2,813059789 0,0480198 0,4517682 2078 4893 NRAS neuroblastoma RAS viral (v- 0,1519415 7,342860349 0,0480339 0,4517682 ras) oncogene homolog

2079 6773 STAT2 signal transducer and 0,16359785 5,108138043 0,0480711 0,45190043 activator of transcription 2, 113kDa 2080 51193 ZNF639 zinc finger protein 639 -0,0845022 8,03451029 0,048132 0,45190681 2081 57419 SLC24A3 solute carrier family 24 0,3073608 9,829386084 0,0481454 0,45190681 (sodium/potassium/calciu m exchanger), member 3

2082 55015 PRPF39 pre-mRNA processing -0,132698 9,139504785 0,0481526 0,45190681 factor 39 2083 131408 FAM131 family with sequence 0,06196848 2,807272393 0,048183 0,45190681 A similarity 131, member A 2084 9919 SEC16A SEC16 homolog A (S. 0,07923992 9,463877044 0,0482206 0,45190681 cerevisiae) 2085 151827 LRRC34 leucine rich repeat -0,2213061 7,209502004 0,0482496 0,45190681 containing 34 2086 23033 DOPEY1 dopey family member 1 -0,0751595 5,888715218 0,0482872 0,45190681

2087 79896 THNSL1 threonine synthase-like 1 -0,1118363 2,554207387 0,0482892 0,45190681 (S. cerevisiae) 2088 11252 PACSIN2 protein kinase C and 0,08629158 6,142303521 0,0483083 0,45190681 casein kinase substrate in neurons 2 2089 55326 AGPAT5 1-acylglycerol-3-phosphate 0,18710257 5,701555648 0,048311 0,45190681 O-acyltransferase 5

2090 590 BCHE butyrylcholinesterase -0,5583008 7,014756687 0,0483261 0,45190681 2091 30815 ST6GALN ST6 (alpha-N-acetyl- -0,1119484 8,210814577 0,0483942 0,45232767 AC6 neuraminyl-2,3-beta- galactosyl-1,3)-N- acetylgalactosaminide alpha-2,6-sialyltransferase 6 2092 55020 TTC38 tetratricopeptide repeat -0,1334535 7,523254833 0,0485265 0,45334665 domain 38 2093 4023 LPL lipoprotein lipase -0,1316818 14,75560963 0,0485753 0,4535865 2094 26130 GAPVD1 GTPase activating protein -0,1008515 8,933258914 0,0486192 0,45374327 and VPS9 domains 1

2095 29088 MRPL15 mitochondrial ribosomal -0,1096197 10,2148119 0,0487071 0,45374327 protein L15 2096 7702 ZNF143 zinc finger protein 143 -0,0912937 7,464723973 0,0487143 0,45374327 2097 10174 SORBS3 sorbin and SH3 domain 0,05507404 3,366148029 0,0487309 0,45374327 containing 3 2098 1E+08 INTS6- INTS6 antisense RNA 1 -0,1234416 5,2839366 0,0487429 0,45374327 AS1 2099 2957 GTF2A1 general transcription -0,0465567 5,738143716 0,0487833 0,45374327 factor IIA, 1, 19/37kDa 2100 151050 KANSL1L KAT8 regulatory NSL -0,109573 6,622676737 0,0487949 0,45374327 complex subunit 1-like 2101 91351 DDX60L DEAD (Asp-Glu-Ala-Asp) 0,24718562 7,998728724 0,0488068 0,45374327 box polypeptide 60-like

2102 5638 PRRG1 proline rich Gla (G- 0,14073022 8,963809349 0,0488393 0,45374327 carboxyglutamic acid) 1 2103 55268 ECHDC2 enoyl CoA hydratase -0,2574604 10,55094332 0,0488552 0,45374327 domain containing 2 2104 5861 RAB1A RAB1A, member RAS 0,10019567 10,74384061 0,0489186 0,45374327 oncogene family 2105 23433 RHOQ ras homolog family 0,14566524 11,8346654 0,0489332 0,45374327 member Q 2106 84809 CROCCP2 ciliary rootlet coiled-coil, 0,15585185 8,489371462 0,0489565 0,45374327 rootletin pseudogene 2

2107 55585 UBE2Q1 ubiquitin-conjugating 0,05100687 5,203247199 0,049002 0,45374327 enzyme E2Q family member 1 2108 283349 RASSF3 Ras association 0,13622368 10,19670302 0,0490149 0,45374327 (RalGDS/AF-6) domain family member 3 2109 4600 MX2 myxovirus (influenza virus) 0,44056474 6,713539187 0,0490214 0,45374327 resistance 2 (mouse)

2110 55239 OGFOD1 2-oxoglutarate and iron- 0,14142472 7,986126104 0,0490267 0,45374327 dependent oxygenase domain containing 1 2111 55435 AP1AR adaptor-related protein -0,1495547 7,325591657 0,049036 0,45374327 complex 1 associated regulatory protein

2112 64747 MFSD1 major facilitator 0,2102272 11,28889511 0,0490653 0,45374327 superfamily domain containing 1 2113 132671 SPATA18 spermatogenesis 0,12259691 4,221886313 0,0490663 0,45374327 associated 18 2114 57561 ARRDC3 arrestin domain containing -0,1635671 10,00823035 0,0490797 0,45374327 3 2115 8220 DGCR14 DiGeorge syndrome critical -0,0409228 3,029443858 0,0491383 0,45406998 region gene 14 2116 9997 SCO2 SCO2 cytochrome c 0,24081601 7,864119732 0,0491882 0,45431707 oxidase assembly protein

2117 4303 FOXO4 forkhead box O4 -0,1352403 6,160053453 0,0492324 0,45433965 2118 51108 METTL9 methyltransferase like 9 -0,0710482 8,21787594 0,0492517 0,45433965

2119 2131 EXT1 exostosin 0,15717495 9,15016538 0,0492604 0,45433965 glycosyltransferase 1 2120 5325 PLAGL1 pleiomorphic adenoma -0,1985523 10,2340228 0,0493265 0,45473472 gene-like 1 2121 84166 NLRC5 NLR family, CARD domain 0,23815809 7,283693356 0,0494138 0,45529482 containing 5 2122 55303 GIMAP4 GTPase, IMAP family 0,16166282 9,139912897 0,049453 0,45529482 member 4 2123 134637 ADAT2 adenosine deaminase, 0,09922068 3,649050862 0,0494695 0,45529482 tRNA-specific 2 2124 719 C3AR1 complement component 0,53361554 8,189858961 0,0494805 0,45529482 3a receptor 1

2125 26610 ELP4 elongator -0,161295 7,576952135 0,0495802 0,45579403 acetyltransferase complex subunit 4 2126 140862 ISM1 isthmin 1, angiogenesis 0,18640274 3,787286869 0,0495814 0,45579403 inhibitor 2127 51367 POP5 processing of precursor 5, 0,14017416 10,46838931 0,0496089 0,45583264 ribonuclease P/MRP subunit (S. cerevisiae) 2128 1487 CTBP1 C-terminal binding protein 0,0943484 10,58133839 0,0497107 0,45601513 1 2129 55619 DOCK10 dedicator of cytokinesis 10 0,45719611 5,801008542 0,0497192 0,45601513

2130 2114 ETS2 v-ets avian 0,24487743 7,249021522 0,0497212 0,45601513 erythroblastosis virus E26 oncogene homolog 2

2131 64844 MARCH7 membrane-associated ring -0,0611885 10,49088717 0,0497487 0,45601513 finger (C3HC4) 7, E3 ubiquitin protein ligase

2132 201163 FLCN folliculin -0,0271034 3,515147926 0,0497527 0,45601513 2133 159195 USP54 ubiquitin specific 0,1173681 5,747254769 0,0497687 0,45601513 peptidase 54 2134 1E+08 ZFHX4- ZFHX4 antisense RNA 1 -0,5777642 3,768597741 0,0498132 0,45620906 AS1 2135 2697 GJA1 gap junction protein, alpha -0,2234642 12,2609551 0,0498383 0,45622502 1, 43kDa Supplementary data S3A Adipocytes - pathways analysis of the significantly changed transcripts in the heavier compared with their leaner co-twins Ingenuity Canonical -log(p- Ratio z-score Molecules Pathways value) 1 Oxidative 1,48E01 4,79E-01 NDUFA4,SDHB,NDUFA7,COX6C,COX10,COX Phosphorylation 5B,COX8A,NDUFB5,ATP5L,NDUFB8,ATP5G2, ATP5S,NDUFA1,NDUFA2,NDUFB10,NDUFB9 ,NDUFAB1,ATPAF1,NDUFS2,ATP5I,ATP5F1,C OX4I1,NDUFS4,NDUFA8,COX6B1,NDUFB4,A TP5O,NDUFS7,ATP5A1,NDUFV3,SURF1,COX 7C,NDUFS3,UQCRB,ATP5C1,NDUFB11,ATP5 B,NDUFA6,UQCR10,UQCRC2,CYC1,COX5A,C OX7A2,NDUFA12,CYB5A,UQCRC1

2 Mitochondrial 1,29E01 3,76E-01 COX8A,NDUFB5,ATP5L,NCSTN,NDUFB8,ATP Dysfunction 5G2,DHODH,NDUFA1,NDUFB10,HTRA2,GPX 4,ATP5F1,NDUFA8,NDUFS7,ATP5A1,SURF1, COX7C,ATP5C1,NDUFB11,ATP5B,NDUFA6,A PH1A,TXN2,UQCRC2,MAPK10,NDUFA12,BA CE2,HSD17B10,NDUFA4,SDHB,NDUFA7,COX 6C,COX5B,COX10,ATP5S,NDUFA2,BCL2,NDU FB9,PARK7,NDUFAB1,NDUFS2,ATPAF1,OGD H,ATP5I,COX4I1,NDUFS4,COX6B1,NDUFB4, ATP5O,NDUFV3,NDUFS3,UQCRB,UQCR10,C YC1,COX5A,COX7A2,CYB5A,UQCRC1,PSEN1

3 Valine Degradation I 5,32E00 6,11E-01 HADHB,BCAT1,ECHS1,BCAT2,ABAT,HIBADH, BCKDHA,ACAD8,ALDH6A1,HADHA,BCKDHB

4 Glucocorticoid Receptor 5,14E00 2,42E-01 YWHAH,MAPK1,SGK1,HSPA1A/HSPA1B,PBX Signaling 1,KRAS,CD163,HSPA5,TAF13,TSC22D3,TGFB R2,CXCL3,IKBKB,PPP3R1,SERPINE1,POLR2I,C XCL8,STAT5A,SELE,CDKN1C,RAC1,POLR2K,G TF2F1,STAT3,PCK1,NCOA3,IL1RN,MAPK10,T NF,UBE2I,POLR2B,NR3C1,PTGES3,PRKAG1,B CL2,HSP90B1,JUN,CCL13,KAT2B,POLR2C,AN XA1,FOXO3,GTF2H5,CHUK,STAT1,MAP2K1, PPP3CA,AGT,ADRB2,MAP2K7,NRAS,IL10,GR B2,CHP1,CEBPB,TSG101,GTF2E1,NFATC2,IL 1B,NRIP1,PLAU,HLTF

5 IL-8 Signaling 5,09E00 2,62E-01 3,130 ANGPT2,MAPK1,GNB2L1,KRAS,IQGAP1,CCN D1,PDGFC,GNG7,BCL2,EIF4EBP1,IRAK1,BRA F,GNB1,VEGFA,IKBKB,HMOX1,JUN,RHOB,G PLD1,CYBB,ITGAV,CXCL1,GNA13,CHUK,MAP 2K1,VASP,ITGB5,GNG12,LASP1,CXCL8,GNAS ,NRAS,GNA12,GNG2,RAC1,IRAK3,PLD1,ITGB 2,CCND2,ITGAM,RHOQ,RHOA,NCF2,MAPK1 0,MAP4K4,FNBP1,IRAK4,MMP9

6 mTOR Signaling 3,88E00 2,43E-01 1,732 TSC1,ULK1,MAPK1,RPS6KA3,KRAS,EIF4A2,P DGFC,RPS11,PRKAG1,EIF4E,EIF4EBP1,VEGF A,HMOX1,RHOB,RPS20,EIF4G2,EIF3B,GPLD 1,TSC2,PPM1L,PPP2R5C,AKT1S1,RPS24,MA PKAP1,NRAS,EIF3H,PPP2R5D,RAC1,PLD1,EIF 3M,RPS6,EIF3G,FAU,PPP2R1A,RHOQ,IRS1,R HOA,RPS27L,EIF3I,INSR,FNBP1,EIF3L,RPS14, EIF3K 7 Role of JAK2 in Hormone- 3,71E00 4,06E-01 STAT5A,SOCS1,PTPN6,GHR,PTPN11,SH2B3,I like Cytokine Signaling RS1,IRS2,STAT3,STAT1,SOCS5,HLTF,SH2B1

8 Isoleucine Degradation I 3,71E00 5,71E-01 HSD17B10,HADHB,BCAT1,ECHS1,BCAT2,AC AD8,ACAT1,HADHA 9 Glutaryl-CoA Degradation 3,69E00 6,36E-01 HSD17B10,HADHB,ACAT1,HADHA,HADH,GC DH,HSD17B8 10 NRF2-mediated Oxidative 3,6E00 2,4E-01 1,225 FTL,GSTM5,MAPK1,DNAJB4,PRDX1,DNAJA4 Stress Response ,HSPB8,DNAJC3,KRAS,DNAJC10,DNAJB2,MA P3K5,CLPP,MAFG,HMOX1,JUN,ABCC1,GST M4,UBE2K,DNAJA3,JUND,TXN,DNAJB1,NFE 2L2,MAP2K1,CBR1,UBB,MAP2K7,DNAJB12, NRAS,GSTM3,NQO1,DNAJC19,JUNB,MAFF,T XNRD1,DNAJC11,MGST2,DNAJB11,DNAJB6, MAP2K5,FTH1

11 Regulation of eIF4 and 3,45E00 2,5E-01 0,905 EIF2B4,MAPK1,EIF4EBP2,KRAS,EIF4A2,EIF2 p70S6K Signaling A,RPS11,EIF4E,EIF4EBP1,EIF1,EIF4G2,RPS20 ,EIF3B,MKNK1,PPM1L,PPP2R5C,MAP2K1,RP S24,NRAS,EIF3H,GRB2,PPP2R5D,EIF2S3,EIF3 M,RPS6,EIF3G,PPP2R1A,FAU,IRS1,RPS27L,EI F3I,EIF3L,EIF1AX,RPS14,EIF3K

12 Clathrin-mediated 3,4E00 2,34E-01 APOE,APOB,F2R,PDGFA,FGF2,ARPC5,PDGFC Endocytosis Signaling ,VEGFA,LYZ,ACTR3,ARRB1,IGF1,PPP3R1,CSN K2A1,DAB2,CSNK2B,SH3KBP1,HGS,PPP3CA,I TGB5,MYO6,UBB,GRB2,ARPC5L,CLTC,CHP1, RAC1,RAB7A,TSG101,FGF1,SH3GL1,ITGB2,C SNK2A2,ARPC1A,SYNJ1,TF,ARPC2,RAB11A,T FRC,UBC,CTTN,CLU,RBP4

13 EIF2 Signaling 3,33E00 2,37E-01 -1,886 RPL11,EIF2AK4,RPL22,EIF2B4,MAPK1,PPP1C B,KRAS,EIF4A2,EIF2A,RPS11,EIF4E,RPL14,EI F1,RPS20,EIF4G2,EIF3B,UBA52,MAP2K1,RPS 24,RPL4,NRAS,EIF3H,GRB2,RPL30,RPL23,EIF 2S3,RPL37A,EIF3M,RPS6,RPL15,EIF3G,FAU, RPS27L,EIF3I,INSR,EIF3L,EIF1AX,RPS14,EIF3 K,RPL38 14 Insulin Receptor Signaling 3,27E00 2,52E-01 TSC1,FYN,EIF2B4,MAPK1,SGK1,PPP1R3C,PP P1CB,INPPL1,KRAS,CRK,PTPRF,EIF4E,PRKAG 1,EIF4EBP1,PTEN,PPP1R12A,FOXO3,TSC2,IR S2,MAP2K1,NRAS,GRB2,PPP1R14A,VAMP2, SLC2A4,RHOQ,PTPN11,FOXO1,SYNJ1,GAB1,I RS1,INSR 15 Fcγ Receptor-mediated 3,19E00 2,72E-01 3,000 FYN,GAB2,MAPK1,ARPC5,CRK,PTEN,HMOX1 Phagocytosis in ,ACTR3,EZR,GPLD1,HCK,VASP,FGR,FCGR3A/ FCGR3B,ARPC5L,RAC1,PLD1,MYO5A,PLA2G Macrophages and 6,ARPC1A,ARPC2,LYN,RAB11A,VAV1,LCP2 Monocytes

16 Acute Phase Response 3,19E00 2,35E-01 3,053 ECSIT,SOCS1,FTL,IL1A,FN1,MAPK1,KRAS,MA Signaling P3K5,HNF1A,RBP1,NR3C1,IRAK1,IKBKB,HM OX1,JUN,OSMR,CHUK,SERPINE1,MAP2K1,T NFRSF11B,AGT,MAP2K7,NRAS,MYD88,GRB 2,C1S,IL6R,CEBPB,STAT3,C5,HP,RBP7,TF,PT PN11,IL1RN,IL1B,TNF,SOCS5,RBP4 17 Phospholipase C Signaling 3,06E00 2,19E-01 2,137 FYN,MAPK1,ARHGEF7,GNB2L1,RPS6KA3,PP P1CB,KRAS,FCGR2B,GNG7,GNB1,HMOX1,PL CE1,RHOB,PPP1R12A,PPP3R1,GPLD1,GNA1 3,MAP2K1,PPP3CA,RALGDS,GNG12,MYL12 A,HDAC9,ARHGEF4,NRAS,ARHGEF12,GNAS, GRB2,PLA2G4C,GNG2,CHP1,RAC1,PPP1R14 A,PLD1,PLA2G4A,CALM1 (includes others),PLA2G6,HDAC3,RHOQ,RHOA,MEF2 D,FCER1G,LYN,NFATC2,ADCY7,ARHGEF10,F NBP1,LCP2

18 PPAR Signaling 2,96E00 2,67E-01 -3,266 PPARG,PPARA,STAT5A,IL1A,NRAS,MAPK1,G RB2,PDGFA,KRAS,PDGFC,IKBKB,HSP90B1,JU N,IL1RN,IL1B,CHUK,INSR,NRIP1,RXRA,TNF, MAP2K1,MAP4K4,CITED2,TNFRSF11B

19 Actin Nucleation by ARP- 2,92E00 3,04E-01 2,500 NRAS,PPP1R12C,ARPC5L,GRB2,GNA12,ARP WASP Complex C5,RAC1,KRAS,RHOQ,ACTR3,ARPC1A,PPP1R 12A,RHOB,ARPC2,RHOA,FNBP1,VASP

20 IL-1 Signaling 2,89E00 2,64E-01 0,688 ECSIT,IL1A,MAP2K7,GNAS,MAPK1,MYD88,G NA12,GNG2,GNB2L1,IRAK3,GNA14,GNG7,P RKAG1,IRAK1,GNB1,IKBKB,JUN,GNA15,MAP K10,CHUK,GNA13,ADCY7,GNG12,IRAK4

21 Role of Tissue Factor in 2,86E00 2,52E-01 FYN,MAPK1,RPS6KA3,KRAS,GNA14,EIF4E,PT Cancer EN,VEGFA,ARRB1,GNA15,ITGAV,HCK,CXCL1, GNA13,FGR,ITGB5,CXCL8,STAT5A,NRAS,GN A12,EGR1,RAC1,PLAUR,PTPN11,LYN,IL1B,CY R61 22 Unfolded protein 2,75E00 3,02E-01 PPARG,MAP2K7,HSPA1A/HSPA1B,CEBPD,D response NAJC3,CANX,ATF6,OS9,CEBPB,MAP3K5,HSP A5,EIF2A,BCL2,SEL1L,HSP90B1,NFE2L2

23 PI3K/AKT Signaling 2,72E00 2,42E-01 3,128 TSC1,GAB2,MAPK1,YWHAH,INPPL1,KRAS,M AP3K5,CCND1,EIF4E,BCL2,PTEN,EIF4EBP1,IK BKB,HSP90B1,PPM1L,TSC2,FOXO3,PPP2R5C ,CHUK,MAP2K1,THEM4,NRAS,GRB2,PPP2R5 D,PPP2R1A,FOXO1,SYNJ1,GAB1,CDKN1B

24 IL-10 Signaling 2,72E00 2,79E-01 CCR1,CCR5,IL1A,MAPK1,IL10,ARG2,STAT3,F CGR2B,HMOX1,IKBKB,JUN,SP1,IL1RN,IL10R A,CD14,IL1B,CHUK,TNF,MAP4K4

25 Aryl Hydrocarbon 2,6E00 2,33E-01 1,460 IL1A,GSTM5,MAPK1,CCND1,FAS,PTGES3,AL Receptor Signaling DH1L1,HSP90B1,NCOA7,JUN,SP1,ALDH1A3, GSTM4,RXRB,NFE2L2,ALDH6A1,AHR,TFDP1, GSTM3,NQO1,NCOA3,CCNE1,CCND2,MGST 2,IL1B,ATR,NRIP1,CDKN1B,RXRA,TNF,MCM 7 26 CD28 Signaling in T 2,53E00 2,43E-01 2,200 FYN,CD4,ARPC5,PTPRC,IKBKB,ACTR3,JUN,P Helper Cells PP3R1,CHUK,MAP2K1,PPP3CA,PTPN6,GRB2 ,ARPC5L,CHP1,RAC1,MALT1,CALM1 (includes others),ARPC1A,PTPN11,ARPC2,MAPK10,FC ER1G,NFATC2,VAV1,LCP2 27 Regulation of IL-2 2,49E00 2,63E-01 FYN,MAP2K7,NRAS,MAPK1,GRB2,CHP1,RAC Expression in Activated 1,KRAS,MALT1,TGFBR2,IKBKB,CALM1 (includes and Anergic T others),JUN,PPP3R1,MAPK10,NFATC2,VAV1 Lymphocytes ,CHUK,MAP2K1,PPP3CA 28 GM-CSF Signaling 2,47E00 2,79E-01 3,207 NRAS,MAPK1,GRB2,GNB2L1,KRAS,STAT3,CC ND1,CSF2RB,PTPN11,PPP3R1,CISH,HCK,LYN ,STAT1,BCL2A1,MAP2K1,PPP3CA

29 Toll-like Receptor 2,41E00 2,64E-01 1,807 ECSIT,PPARA,IL1A,UBB,MAPK1,MYD88,TNF Signaling AIP3,IRAK3,IRAK1,IKBKB,JUN,IL1RN,CD14,IL 1B,CHUK,UBC,MAP4K4,TNF,IRAK4

30 Leucine Degradation I 2,39E00 5,56E-01 BCAT1,BCAT2,MCCC1,HMGCL,MCCC2 31 SAPK/JNK Signaling 2,39E00 2,5E-01 1,706 MAP2K7,NRAS,GRB2,GNA12,GNG2,RAC1,CR K,KRAS,MAP3K5,GNG7,GNB1,MAP4K3,JUN, GADD45A,GAB1,DUSP10,IRS1,MAPK10,FCE R1G,DUSP4,GNA13,MAP4K4

32 IL-6 Signaling 2,33E00 2,33E-01 3,138 SOCS1,IL1A,MAPK1,KRAS,VEGFA,IKBKB,JUN, CSNK2A1,CSNK2B,CHUK,MAP2K1,TNFRSF11 B,CXCL8,MAP2K7,NRAS,GRB2,IL6R,CEBPB,S TAT3,CSNK2A2,PTPN11,IL1RN,MAPK10,CD1 4,IL1B,MAP4K4,TNF 33 Role of JAK family kinases 2,31E00 3,6E-01 SOCS1,STAT5A,PTPN11,MAPK1,IL6R,MAPK1 in IL-6-type Cytokine 0,OSMR,STAT3,STAT1 Signaling 34 Thyroid Cancer Signaling 2,26E00 3,08E-01 PPARG,BRAF,NRAS,MAPK1,KRAS,CXCL1,TCF 7L1,RXRB,RXRA,MAP2K1,CCND1,HNF1A

35 PI3K Signaling in B 2,26E00 2,28E-01 CD81,FYN,MAPK1,ATF6,KRAS,FCGR2B,PTEN Lymphocytes ,PTPRC,IKBKB,JUN,PLCE1,PPP3R1,FOXO3,IR S2,CHUK,MAP2K1,PPP3CA,NRAS,CHP1,RAC 1,MALT1,CALM1 (includes others),IRS1,LYN,NFATC2,VAV1,PIK3AP1,PL EKHA1 36 Ketogenesis 2,14E00 5E-01 HADHB,BDH1,ACAT1,HMGCL,HADHA 37 Estrogen Receptor 2,11E00 2,22E-01 MAPK1,KRAS,POLR2B,NR3C1,TAF13,POLR2 Signaling C,CDK8,KAT2B,THRAP3,MED10,GTF2H5,ME D16,MAP2K1,POLR2I,PELP1,NRAS,MED20,G RB2,PHB2,GTF2F1,POLR2K,PCK1,MED12,NC OA3,HDAC3,GTF2E1,NRIP1,CARM1

38 B Cell Receptor Signaling 2,07E00 2,1E-01 GAB2,RAP2A,MAPK1,INPPL1,KRAS,MAP3K5, BCL6,FCGR2B,PTEN,PTPRC,IKBKB,JUN,PPP3 R1,CHUK,MAP2K1,PPP3CA,PTPN6,MAP2K7, NRAS,GRB2,EGR1,RAC1,MALT1,CALM1 (includes others),EBF1,PTPN11,FOXO1,SYNJ1,GAB1,P AG1,LYN,NFATC2,VAV1,PIK3AP1,BCL2A1

39 Production of Nitric 2,06E00 2,07E-01 1,000 PPARA,APOE,APOB,MAPK1,PPP1R3C,PPP1C Oxide and Reactive B,ARG2,MAP3K5,IKBKB,LYZ,JUN,RHOB,PPP1 R12A,CYBA,PPM1L,CYBB,PPP2R5C,CHUK,ST Oxygen Species in AT1,MAP2K1,TNFRSF11B,PTPN6,MAP2K7,P Macrophages PP2R5D,RAC1,IFNGR2,PPP1R14A,NCF4,PPP 2R1A,RHOQ,RHOA,NCF2,MAPK10,TNF,FNBP 1,CLU,RBP4 40 Airway Pathology in 2,03E00 5,71E-01 CXCL8,CXCL3,TNF,MMP9 Chronic Obstructive Pulmonary Disease 41 Superpathway of Serine 2,03E00 5,71E-01 PSAT1,PHGDH,SHMT1,SHMT2 and Glycine Biosynthesis I

42 Ketolysis 2,03E00 5,71E-01 HADHB,BDH1,ACAT1,HADHA 43 2-ketoglutarate 2,01E00 7,5E-01 DHTKD1,DLST,OGDH Dehydrogenase Complex

44 Glioma Invasiveness 2E00 2,63E-01 2,324 NRAS,F2R,MAPK1,PLAUR,KRAS,RHOQ,RHOB Signaling ,TIMP1,RHOA,ITGAV,PLAU,FNBP1,MMP9,IT GB5,TIMP2 45 TCA Cycle II (Eukaryotic) 2E00 3,48E-01 SDHB,IDH3G,DHTKD1,SUCLG1,DLST,MDH2, OGDH,IDH3B 46 PTEN Signaling 2E00 2,22E-01 -1,043 YWHAH,MAPK1,INPPL1,KRAS,CCND1,PTEN, BCL2,TGFBR2,IKBKB,FOXO3,CSNK2A1,CHUK, CSNK2B,MAP2K1,NRAS,GRB2,RAC1,CNKSR3 ,CSNK2A2,GHR,MAGI1,SYNJ1,FOXO1,CDKN1 B,INSR,MAGI2 47 Pancreatic 1,98E00 2,26E-01 1,213 MAPK1,TFDP1,GRB2,SUV39H1,RAC1,KRAS,S Adenocarcinoma TAT3,PDGFC,CDKN2B,CCND1,SIN3A,PLD1,B CL2,VEGFA,TGFBR2,HMOX1,CCNE1,GPLD1, Signaling MAPK10,CDKN1B,STAT1,MAP2K1,RALGDS, MMP9 48 Role of NFAT in 1,96E00 2,09E-01 2,600 FYN,MAPK1,CD4,GNB2L1,KRAS,GNA14,FCG Regulation of the R2B,GNG7,GNB1,CSNK1E,IKBKB,JUN,GNA15 ,PPP3R1,CHUK,GNA13,MAP2K1,PPP3CA,FC Immune Response GR3A/FCGR3B,GNG12,GNAS,NRAS,GRB2,G NA12,CSNK1G3,GNG2,CHP1,CALM1 (includes others),MEF2D,FCER1G,LYN,NFATC2,LCP2

49 GADD45 Signaling 1,95E00 3,68E-01 CCNE1,CCND2,GADD45B,GADD45A,GADD4 5G,ATR,CCND1 50 Tryptophan Degradation 1,95E00 3,68E-01 HSD17B10,HADHB,ACAT1,HADHA,HADH,GC III (Eukaryotic) DH,HSD17B8

51 fMLP Signaling in 1,93E00 2,24E-01 2,400 FPR3,NRAS,GNAS,MAPK1,ARPC5L,CHP1,GN Neutrophils G2,ARPC5,GNB2L1,RAC1,KRAS,GNG7,GNB1, CALM1 (includes others),ACTR3,ARPC1A,ARPC2,PPP3R1,NCF 2,CYBB,NFATC2,MAP2K1,GNG12,PPP3CA

52 IGF-1 Signaling 1,92E00 2,29E-01 0,728 IGFBP4,SOCS1,NRAS,YWHAH,MAPK1,GRB2, KRAS,STAT3,PRKAG1,CSNK2A2,JUN,FOXO1,I GF1,PTPN11,IRS1,FOXO3,CSNK2A1,IRS2,CS NK2B,CYR61,SOCS5,MAP2K1

53 iNOS Signaling 1,9E00 2,79E-01 1,508 IKBKB,CALM1 (includes others),JUN,MAPK1,MYD88,IFNGR2,CD14,C HUK,IRAK3,STAT1,IRAK4,IRAK1 54 Protein Ubiquitination 1,86E00 1,91E-01 ANAPC2,USP24,USP12,CRYAB,USP45,UBE2 Pathway A,PSMA7,DNAJB4,USP11,HSPA1A/HSPA1B, HSPB8,FBXW7,DNAJC3,DNAJC10,DNAJB2,H SPA5,USP39,UBE2F,SMURF1,UCHL1,HSP90 B1,USP13,PSMD14,DNAJB1,DNAJC30,PSMC 2,NEDD4L,UBB,DNAJB12,MED20,UBE4B,UB E2R2,DNAJC19,USP30,USP33,DNAJC11,UCH L3,DNAJB11,UBR1,HSPA13,HSPB11,PSMA4, USP46,PSMD1,DNAJB6,UBC,UBE2J2,UBE2I

55 Fatty Acid β-oxidation I 1,84E00 3,1E-01 HSD17B10,HADHB,ECHS1,SLC27A2,ECI2,ECI 1,HADHA,HADH,HSD17B8 56 RAR Activation 1,84E00 2,02E-01 AKR1C3,MAPK1,RDH10,ADH1C,MAP3K5,RB P1,PRKAG1,PTEN,VEGFA,JUN,KAT2B,ALDH1 A3,PNRC1,CSNK2A1,GTF2H5,CSNK2B,RXRB, ZBTB16,MAP2K1,CITED2,STAT5A,DHRS3,GN AS,RELB,RAC1,CSF2RB,CSNK2A2,RBP7,MAP K10,NRIP1,RXRA,ADCY7,HLTF,CARM1,RBP4

57 Oncostatin M Signaling 1,82E00 2,94E-01 2,530 STAT5A,NRAS,MAPK1,GRB2,OSMR,KRAS,ST AT3,PLAU,STAT1,MAP2K1 58 p53 Signaling 1,82E00 2,24E-01 1,604 HDAC9,PMAIP1,GADD45B,GADD45G,RRM2 B,C12orf5,PERP,ST13,CCND1,FAS,BCL2,PTE N,CCNG1,MDM4,CCND2,JUN,KAT2B,GADD4 5A,ADCK3,SIRT1,ATR,TNFRSF10A

59 Antiproliferative Role of 1,79E00 2,5E-01 1,732 PTPN6,NRAS,MAPK1,GNB2L1,GNG2,KRAS,G Somatostatin Receptor 2 NG7,BRAF,GNB1,PTPN11,SSTR2,NPR1,CDKN 1B,MAP2K1,GNG12

60 Androgen Signaling 1,79E00 2,18E-01 -0,378 POLR2I,GNAS,MAPK1,GNA12,GNG2,GNB2L 1,GTF2F1,POLR2K,GNA14,POLR2B,CCND1,P RKAG1,GNG7,GNB1,CALM1 (includes others),JUN,KAT2B,POLR2C,GNA15,GTF2E1, GTF2H5,GNA13,DNAJB1,GNG12

61 IL-3 Signaling 1,78E00 2,39E-01 STAT5A,GAB2,PTPN6,NRAS,MAPK1,GRB2,C HP1,RAC1,KRAS,STAT3,CSF2RB,JUN,FOXO1, PPP3R1,STAT1,MAP2K1,PPP3CA

62 RAN Signaling 1,77E00 3,75E-01 KPNA3,KPNA5,RCC1,KPNA2,KPNA1,IPO5

63 Adipogenesis pathway 1,77E00 2,13E-01 DGKD,FGF2,CEBPD,FBXW7,RBP1,EGR2,LPIN 1,AGPAT2,SETDB1,GTF2H5,PPARG,HDAC9,T XNIP,CEBPB,SLC2A4,SIN3A,FGF1,EBF1,HDAC 3,SIRT2,FOXO1,KDM1A,SIRT1,KLF5,TNF,PER 2 64 PDGF Signaling 1,75E00 2,34E-01 0,943 NRAS,MAPK1,GRB2,PDGFA,INPPL1,CRK,KRA S,STAT3,PDGFC,CSNK2A2,JUN,SYNJ1,ABL2,C AV1,CSNK2A1,CSNK2B,STAT1,MAP2K1

65 Cardiac Hypertrophy 1,74E00 1,93E-01 0,324 EIF2B4,MAPK1,GNB2L1,ATF6,KRAS,MAP3K5 Signaling ,GNA14,PRKAG1,GNG7,EIF4E,GNB1,TGFBR2 ,ADRB1,PLCE1,JUN,GNA15,RHOB,IGF1,PPP3 R1,GNA13,MAP2K1,PPP3CA,GNG12,ADRB2, MYL12A,MAP2K7,NRAS,GNAS,MAPKAPK3,G RB2,GNA12,IL6R,GNG2,CHP1,CALM1 (includes others),RHOQ,IRS1,RHOA,MEF2D,MAPK10, ADCY7,FNBP1 66 Ethanol Degradation II 1,74E00 3E-01 HSD17B10,ALDH2,ADH1A,ACSS3,ALDH1A3, ACSS2,ADH1C,ADH1B,ADHFE1 67 Breast Cancer Regulation 1,73E00 1,97E-01 CAMK1,MAPK1,ARHGEF7,PPP1R3C,GNB2L1 by Stathmin1 ,PPP1CB,KRAS,TUBB,PRKAG1,GNG7,TUBB2 B,GNB1,PPP1R12A,PPM1L,PPP2R5C,GNA13, MAP2K1,GNG12,ARHGEF4,GNAS,ARHGEF12 ,NRAS,GRB2,PPP2R5D,GNG2,TUBB2A,RAC1, PPP1R14A,TSG101,CALM1 (includes others),PPP2R1A,CCNE1,RHOA,UHMK1,CDK N1B,ARHGEF10,ADCY7 68 Signaling by Rho Family 1,72E00 1,9E-01 1,915 PPP1R12C,MAPK1,ARHGEF7,GNB2L1,ARPC5 GTPases ,WASF3,GNA14,IQGAP1,GNG7,CLIP1,GNB1, ACTR3,JUN,GNA15,RHOB,PPP1R12A,EZR,CY BB,GNA13,MAP2K1,GNG12,MYL12A,SEPT8, MAP2K7,ARHGEF4,GNAS,ARHGEF12,ARPC5 L,GNA12,GNG2,RAC1,CDC42EP4,PLD1,ARPC 1A,RHOQ,ARPC2,RHOA,NCF2,MAPK10,PAR D3,PIP4K2A,ARHGEF10,FNBP1,MSN

69 UDP-D-xylose and UDP-D- 1,71E00 1E00 UXS1,UGDH glucuronate Biosynthesis

70 β-alanine Degradation I 1,71E00 1E00 ABAT,ALDH6A1

71 Glycine Biosynthesis I 1,71E00 1E00 SHMT1,SHMT2 72 Hepatic Fibrosis / Hepatic 1,7E00 1,95E-01 MYH10,IGFBP4,TNFSF4,IL1A,CCR5,FN1,PDG Stellate Cell Activation FA,FGF2,PDGFC,FAS,BCL2,TGFBR2,COL16A1 ,VEGFA,CXCL3,COL6A1,IGF1,TIMP1,ECE1,ST AT1,SERPINE1,TNFSF13B,TNFRSF11B,TIMP2 ,AGT,CXCL8,COL5A2,IL10,COL12A1,IL6R,IFN GR2,FGF1,IL10RA,CD14,IL1B,TNF,MMP9,CO L3A1 73 HMGB1 Signaling 1,69E00 2,12E-01 1,633 IL1A,MAPK1,IL17C,KRAS,KAT2B,JUN,RHOB,S P1,IL17D,SERPINE1,MAP2K1,TNFRSF11B,CX CL8,SELE,MAP2K7,NRAS,RAC1,IFNGR2,RHO Q,RHOA,MAPK10,IL1B,TNF,FNBP1,MAP2K5

74 Role of Macrophages, 1,68E00 1,84E-01 SOCS1,MAPK1,KRAS,CCND1,VEGFA,IKBKB,P Fibroblasts and LCE1,PPP3R1,TNFSF13B,TNFRSF11B,SFRP4, CXCL8,MIF,SELE,IL6R,RAC1,STAT3,C5,IL1RN, Endothelial Cells in RHOA,TNF,IL1A,FN1,FRZB,PDGFA,FGF2,CEB Rheumatoid Arthritis PD,IL17RA,PDGFC,HNF1A,IRAK1,JUN,NLK,C HUK,MAP2K1,FCGR3A/FCGR3B,PPP3CA,MA P2K7,NRAS,C5AR1,IL10,MYD88,CHP1,IL15,C EBPB,TCF7L1,IRAK3,CALM1 (includes others),IL1B,NFATC2,WNT11,IRAK4

75 CCR5 Signaling in 1,67E00 2,42E-01 CCR5,GNAS,MAPK1,CD4,GNB2L1,GNG2,GN Macrophages G7,FAS,GNB1,CALM1 (includes others),JUN,CCL4,MAPK10,FCER1G,GNG12

76 Prolactin Signaling 1,66E00 2,33E-01 1,291 STAT5A,FYN,SOCS1,NRAS,MAPK1,GRB2,KRA S,STAT3,CEBPB,NR3C1,JUN,SP1,PTPN11,IRS 1,STAT1,SOCS5,MAP2K1 77 Ephrin Receptor Signaling 1,66E00 1,98E-01 FYN,RGS3,MAPK1,PDGFA,GNB2L1,ARPC5,K RAS,CRK,EPHA4,GNA14,PDGFC,GNG7,GRIN A,GNB1,VEGFA,ACTR3,GNA15,GNA13,MAP 2K1,GNG12,GNAS,NRAS,GRB2,ARPC5L,GNA 12,GNG2,RAC1,STAT3,FGF1,ARPC1A,PTPN1 1,ARPC2,RHOA,MAP4K4

78 Folate Polyglutamylation 1,66E00 6E-01 SHMT1,MTHFD1,SHMT2

79 Complement System 1,65E00 2,78E-01 1,633 ITGB2,ITGAM,C5AR1,C1S,C1QC,C1QA,C6,C1 QB,C3AR1,C5 80 Role of MAPK Signaling in 1,61E00 2,38E-01 PLA2G16,MAP2K7,NRAS,MAPK1,PLA2G4C,K the Pathogenesis of RAS,MAP3K5,PRDX6,RABGEF1,BCL2,PLA2G 6,PLA2G4A,MAPK10,TNF,MAP2K1 Influenza 81 LXR/RXR Activation 1,6E00 2,08E-01 -2,683 APOE,IL1A,APOB,CD36,ARG2,CETP,FDFT1,L YZ,FASN,RXRB,AGT,TNFRSF11B,MLXIPL,ECH S1,TF,IL1RN,CD14,IL1B,ACACA,RXRA,TNF,M MP9,HADH,CLU,RBP4 82 Folate Transformations I 1,57E00 4,44E-01 SHMT1,MTR,MTHFD1,SHMT2

83 Superpathway of 1,57E00 2,96E-01 MVD,HADHB,FDFT1,ACAT1,LSS,TM7SF2,HA Cholesterol Biosynthesis DHA,SC5D

84 Inhibition of Angiogenesis 1,56E00 2,81E-01 0,000 VEGFA,TGFBR2,FYN,CD47,JUN,MAPK1,CD36 by TSP1 ,MAPK10,MMP9 85 Remodeling of Epithelial 1,55E00 2,34E-01 1,414 ARPC5L,MAPRE1,ARPC5,TUBB2A,RAB7A,IQ Adherens Junctions GAP1,TUBB,MAPRE2,CLIP1,TUBB2B,ACTR3, ARPC1A,ARPC2,EXOC2,HGS

86 Induction of Apoptosis by 1,52E00 2,37E-01 0,000 MAP2K7,SLC25A3,MAP3K5,SLC25A5,FAS,BC HIV1 L2,IKBKB,SLC25A6,MAPK10,BID,HTRA2,CHU K,TNF,TNFRSF11B 87 Phosphatidylglycerol 1,51E00 3,33E-01 LCLAT1,AGPAT2,PTPMT1,AGPAT9,AGPAT3, Biosynthesis II (Non- CDS2 plastidic) 88 tRNA Charging 1,49E00 2,63E-01 WARS2,VARS2,TARSL2,GARS,KARS,DARS,IA RS,FARSA,EPRS,QARS 89 PPARα/RXRα Activation 1,49E00 1,94E-01 -0,577 PPARA,MAPK1,CD36,KRAS,GNA14,PRKAG1, TGFBR2,IKBKB,HSP90B1,JUN,PLCE1,GNA15, FASN,CHUK,MAP2K1,ACVR1C,ITGB5,MAP2K 7,GNAS,NRAS,GRB2,ACVR1,MED12,NCOA3, GHR,GK,IRS1,IL1B,INSR,RXRA,MAP4K4,ADC Y7 90 Differential Regulation of 1,48E00 3,04E-01 IL1A,CCL4,IL10,IL1B,DEFB1,CXCL1,TNF Cytokine Production in Intestinal Epithelial Cells by IL-17A and IL-17F

91 Epithelial Adherens 1,48E00 1,99E-01 MYH10,ARPC5,KRAS,CRK,TUBB,IQGAP1,HN Junction Signaling F1A,CLIP1,TUBB2B,PTEN,TGFBR2,AGGF1,AC TR3,ACVR1C,NRAS,ARPC5L,TUBB2A,ACVR1, RAC1,TCF7L1,FGF1,MAGI1,ARPC1A,ARPC2,R HOA,MAGI2,CLINT1,PARD3

92 T Cell Receptor Signaling 1,47E00 2,13E-01 FYN,NRAS,MAPK1,GRB2,CD4,RAC1,KRAS,M ALT1,PTPRC,IKBKB,CALM1 (includes others),JUN,PAG1,PPP3R1,NFATC2,VAV1,CH UK,MAP2K1,LCP2,PPP3CA 93 Protein Kinase A Signaling 1,44E00 1,74E-01 MYH10,YWHAH,MAPK1,PDE3A,PDE12,GNB 2L1,TIMM50,PTEN,TGFBR2,PTPRC,GNB1,PL CE1,PPP3R1,GNA13,APEX1,GNG12,PHKG1,K DELR1,PTPN6,PTPRG,PPP1R1B,GNG2,PPP1 R14A,PTPN3,PDE4B,PTP4A1,AKAP13,PYGM, PTPN11,RHOA,PTPRB,PDE1B,DUSP4,H1F0,A NAPC2,DUSP6,PPP1R3C,PPP1CB,DUSP22,PT PN12,HNF1A,PHKA2,PTPRF,GNG7,PRKAG1, BRAF,PPP1R12A,DUSP10,H1FX,CHUK,MAP2 K1,PPP3CA,VASP,MYL12A,GNAS,CHP1,TCF7 L1,CALM1 (includes others),PTPRU,ADD3,KDELR3,NFATC2,ADCY 7,AKAP1 94 JAK/Stat Signaling 1,42E00 2,22E-01 1,000 STAT5A,SOCS1,PTPN6,NRAS,MAPK1,GRB2,K RAS,STAT3,CEBPB,STAT4,JUN,PTPN11,CISH, STAT1,SOCS5,MAP2K1 95 AMPK Signaling 1,41E00 1,98E-01 -0,655 CAB39,TSC1,MAPK1,PFKL,PRKAG1,EIF4EBP1 ,ADRB1,KAT2B,FASN,PPM1L,TSC2,PPP2R5C, IRS2,ADRB2,PFKFB3,GNAS,ACACB,PPP2R5D, SLC2A4,PPM1G,PPP2R1A,IRS1,ACACA,INSR, MLYCD,HLTF 96 Sphingosine and 1,41E00 5E-01 NAAA,SGPP1,ASAH1 Sphingosine-1-phosphate Metabolism

97 Chondroitin and 1,41E00 5E-01 CHSY3,CHSY1,CSGALNACT1 Dermatan Biosynthesis

98 GDP-mannose 1,41E00 5E-01 GPI,PMM1,MPI Biosynthesis 99 Nur77 Signaling in T 1,38E00 2,44E-01 CALM1 (includes Lymphocytes others),HDAC9,PPP3R1,MEF2D,CHP1,FCER1 G,RXRA,MAP2K5,SIN3A,PPP3CA,BCL2

100 ErbB2-ErbB3 Signaling 1,37E00 2,32E-01 2,111 STAT5A,NRAS,MAPK1,GRB2,KRAS,STAT3,CC ND1,PTEN,JUN,SP1,FOXO1,CDKN1B,MAP2K 1 101 Ephrin B Signaling 1,37E00 2,19E-01 1,633 GNAS,RGS3,MAPK1,GNA12,GNB2L1,GNG2, RAC1,GNA14,GNG7,GNB1,GNA15,RHOA,CA P1,VAV1,GNA13,GNG12 102 Antioxidant Action of 1,34E00 2,09E-01 -0,500 PLA2G16,STAT5A,MAPK1,PLA2G4C,SLC2A4, Vitamin C PRDX6,TXNRD1,PLD1,PLA2G4A,CSF2RB,HM OX1,IKBKB,PLA2G6,PLCE1,GPLD1,MAPK10,C HUK,TXN,TNF 103 Acute Myeloid Leukemia 1,32E00 2,16E-01 -0,258 STAT5A,MAP2K7,NRAS,MAPK1,GRB2,KRAS, Signaling TCF7L1,STAT3,CCND1,CSF1R,HNF1A,EIF4EB P1,BRAF,CSF2RB,MAP2K1,MAP2K5

104 Chronic Myeloid 1,3E00 2,07E-01 STAT5A,GAB2,HDAC9,NRAS,MAPK1,TFDP1, Leukemia Signaling GRB2,SUV39H1,CRK,KRAS,CCND1,SIN3A,TG FBR2,IKBKB,HDAC3,PTPN11,CHUK,CDKN1B, MAP2K1 105 Cell Cycle: G1/S 1,3E00 2,22E-01 -0,577 RPL11,HDAC9,CCNE1,CCND2,HDAC3,FOXO1 Checkpoint Regulation ,TFDP1,SUV39H1,CDKN2C,ATR,CDKN1B,CDK N2B,CCND1,SIN3A 106 CDK5 Signaling 1,3E00 2,04E-01 0,000 LAMA5,GNAS,NRAS,MAPK1,PPP1R1B,EGR1, PPP2R5D,PPP1R3C,MAPK6,PPP1CB,PPP1R1 4A,KRAS,PRKAG1,PPP2R1A,PPP1R12A,PPM 1L,MAPK10,PPP2R5C,MAP2K1,ADCY7

107 IL-17A Signaling in Gastric 1,3E00 2,8E-01 CXCL8,JUN,MAPK1,MAPK10,CXCL1,IL17RA,T Cells NF 108 Actin Cytoskeleton 1,29E00 1,82E-01 MYH10,FN1,F2R,MAPK1,PDGFA,FGF2,ARHG Signaling EF7,ARPC5,PPP1CB,KRAS,CRK,IQGAP1,PDGF C,IQGAP2,ACTR3,PPP1R12A,EZR,GNA13,SS H2,MAP2K1,GNG12,MYL12A,ARHGEF4,ARH GEF12,NRAS,ARPC5L,GRB2,GNA12,RAC1,FG F1,ARPC1A,ARPC2,RHOA,CD14,VAV1,NCKA P1L,PIP4K2A,MSN

109 Methionine Salvage II 1,27E00 6,67E-01 MTR,BHMT2 (Mammalian) 110 4-aminobutyrate 1,27E00 6,67E-01 SUCLG2,ABAT Degradation I 111 Fatty Acid β-oxidation III 1,27E00 6,67E-01 ECI2,ECI1 (Unsaturated, Odd Number) 112 3-phosphoinositide 1,27E00 1,93E-01 PPP1R12C,NUDT12,PPFIBP2,PTPMT1,IGBP1 Degradation ,INPPL1,PTPN12,PTPRF,SACM1L,PTEN,PTPR C,PPP1R12A,DUSP10,NUDT4,RNGTT,PPP3C A,PPFIA1,PTPN6,PPP1R1B,PPP1R8,PPP2R5D ,MTMR14,PPP1R14A,PPP4R1,PTPN11,SYNJ 1 113 Atherosclerosis Signaling 1,26E00 1,97E-01 PLA2G16,APOE,CXCL8,IL1A,SELE,APOB,PDG FA,CD36,PLA2G4C,PDGFC,PRDX6,TNFRSF12 A,PLA2G4A,PLA2G6,ITGB2,LYZ,IL1RN,IL1B,T NF,MMP9,CLU,COL3A1,RBP4

114 Cholecystokinin/Gastrin- 1,26E00 2,02E-01 2,236 IL1A,NRAS,MAPK1,GRB2,GNA12,EPHA4,KRA mediated Signaling S,RHOQ,JUN,RHOB,IL1RN,RHOA,MEF2D,MA PK10,IL1B,GNA13,TNF,MAP2K1,MAP2K5,FN BP1 115 IL-2 Signaling 1,23E00 2,26E-01 2,121 SOCS1,CSNK2A2,STAT5A,JUN,NRAS,PTPN11 ,MAPK1,GRB2,CSNK2A1,KRAS,CSNK2B,MAP 2K1 116 D-myo-inositol (1,4,5,6)- 1,23E00 1,95E-01 PPFIA1,PTPN6,PPP1R12C,PPP1R8,PPP1R1B, Tetrakisphosphate PPP2R5D,NUDT12,PPFIBP2,PPP1R14A,IGBP 1,PPP4R1,PTPN12,PTPRF,PTEN,SACM1L,PTP Biosynthesis RC,SYNJ1,PTPN11,PPP1R12A,DUSP10,NUDT 4,RNGTT,PPP3CA 117 D-myo-inositol (3,4,5,6)- 1,23E00 1,95E-01 PPFIA1,PTPN6,PPP1R12C,PPP1R8,PPP1R1B, tetrakisphosphate PPP2R5D,NUDT12,PPFIBP2,PPP1R14A,IGBP 1,PPP4R1,PTPN12,PTPRF,PTEN,SACM1L,PTP Biosynthesis RC,SYNJ1,PTPN11,PPP1R12A,DUSP10,NUDT 4,RNGTT,PPP3CA 118 Type II Diabetes Mellitus 1,22E00 1,96E-01 PPARG,SOCS1,MAP2K7,MAPK1,SLC27A2,CD Signaling 36,PKM,SMPD1,MAP3K5,CEBPB,SLC2A4,PR KAG1,IKBKB,IRS1,MAPK10,IRS2,CHUK,INSR, TNF,SOCS5,NSMAF,TNFRSF11B

119 Fc Epsilon RI Signaling 1,22E00 1,98E-01 2,236 FYN,MAP2K7,NRAS,MAPK1,GRB2,PLA2G4C, RAC1,INPPL1,KRAS,PLA2G6,PLA2G4A,SYNJ1 ,PTPN11,GAB1,MAPK10,FCER1G,LYN,VAV1, TNF,MAP2K1,LCP2 120 CDP-diacylglycerol 1,21E00 3,12E-01 LCLAT1,AGPAT2,AGPAT9,AGPAT3,CDS2 Biosynthesis I 121 Superpathway of 1,21E00 3,12E-01 MVD,HADHB,COX10,ACAT1,HADHA Geranylgeranyldiphospha te Biosynthesis I (via Mevalonate) 122 Inositol Pyrophosphates 1,21E00 4,29E-01 IPPK,IP6K1,IP6K2 Biosynthesis

123 Sphingomyelin 1,21E00 4,29E-01 SGMS2,SMPD1,SGMS1 Metabolism 124 Endoplasmic Reticulum 1,21E00 2,86E-01 HSP90B1,DNAJC3,ATF6,MAP3K5,HSPA5,TA Stress Pathway OK3 125 Cyclins and Cell Cycle 1,19E00 2,08E-01 0,577 HDAC9,TFDP1,SUV39H1,PPP2R5D,CDKN2C, Regulation CCND1,CDKN2B,SIN3A,CCNE1,PPP2R1A,HD AC3,CCND2,PPM1L,ATR,PPP2R5C,CDKN1B

126 Tec Kinase Signaling 1,19E00 1,87E-01 1,886 FYN,GNB2L1,GNA14,FAS,GNG7,GNB1,RHOB ,GNA15,HCK,GNA13,STAT1,TNFRSF10A,FGR ,GNG12,STAT5A,GNAS,GNA12,GNG2,STAT3, STAT4,RHOQ,RHOA,LYN,MAPK10,FCER1G,V AV1,TNF,FNBP1 127 Integrin Signaling 1,18E00 1,8E-01 3,413 FYN,RAP2A,MAPK1,ARHGEF7,ARPC5,PPP1C B,KRAS,CRK,PTEN,BRAF,PARVB,ACTR3,RHO B,PPP1R12A,ARF4,ITGAV,CAV1,MAP2K1,ITG B5,VASP,MYL12A,NRAS,GRB2,ARPC5L,RAC1 ,TSPAN2,ITGB2,RHOQ,ARPC1A,ITGAM,ARPC 2,RHOA,CTTN,NEDD9,FNBP1

128 Cardiac β-adrenergic 1,17E00 1,89E-01 -0,471 GNAS,PPP2R5D,PPP1R3C,PDE3A,PDE12,GN Signaling G2,GNB2L1,PPP1R14A,PPP1CB,PDE4B,GNG 7,PRKAG1,GNB1,AKAP13,PPP2R1A,ADRB1,P PP1R12A,PDE1B,PPM1L,PPP2R5C,PKIA,ADC Y7,APEX1,GNG12,AKAP1

129 ERK/MAPK Signaling 1,14E00 1,8E-01 1,768 FYN,MAPK1,YWHAH,DUSP6,PPP1R3C,PPP1 CB,KRAS,CRK,PRKAG1,EIF4E,EIF4EBP1,BRAF, PPP1R12A,MKNK1,PPM1L,PPP2R5C,STAT1, MAP2K1,PPARG,NRAS,GRB2,PPP2R5D,PLA2 G4C,RAC1,MAPKAPK5,PPP1R14A,MKNK2,ST AT3,ELF1,PLA2G4A,PLA2G6,PPP2R1A,DUSP 4 130 Cleavage and 1,13E00 3,33E-01 CPSF2,NUDT21,CSTF3,WDR33 Polyadenylation of Pre- mRNA 131 Assembly of RNA 1,13E00 3,33E-01 GTF3C1,GTF3C3,GTF3C5,BRF2 Polymerase III Complex

132 Mevalonate Pathway I 1,13E00 3,33E-01 MVD,HADHB,ACAT1,HADHA 133 Thrombopoietin Signaling 1,13E00 2,18E-01 1,155 GAB2,STAT5A,JUN,NRAS,PTPN11,MAPK1,G RB2,IRS2,KRAS,STAT3,STAT1,MAP2K1

134 Rac Signaling 1,11E00 1,94E-01 2,357 MAP2K7,NRAS,MAPK1,ARPC5L,ARPC5,RAC1 ,KRAS,IQGAP1,PLD1,IQGAP2,JUN,ARPC1A,A CTR3,ARPC2,RHOA,NCF2,CYBB,PARD3,MAP 2K1,PIP4K2A 135 STAT3 Pathway 1,11E00 2,05E-01 SOCS1,PTPN6,NRAS,MAPK1,RAC1,KRAS,STA T3,BCL2,TGFBR2,GHR,CISH,MAPK10,INSR,S OCS5,MAP2K1 136 D-myo-inositol-5- 1,11E00 1,87E-01 PPP1R12C,NUDT12,PPFIBP2,IGBP1,PTPN12, phosphate Metabolism PTPRF,SACM1L,PTEN,PTPRC,PLCE1,PPP1R1 2A,DUSP10,NUDT4,RNGTT,PPP3CA,PPFIA1, PTPN6,PPP1R1B,PPP1R8,PPP2R5D,PPP1R14 A,PPP4R1,SYNJ1,PTPN11,PIP4K2A

137 Triacylglycerol 1,1E00 2,42E-01 LPIN1,LCLAT1,PPP2R2D,AGPAT2,AGPAT9,D Biosynthesis GAT1,AGPAT3,PPAP2A 138 Amyloid Processing 1,09E00 2,2E-01 CSNK1E,CSNK2A2,MAPK1,APH1A,MARK1,CS NK2A1,NCSTN,CSNK2B,BACE2,PRKAG1,PSE N1 139 Prostate Cancer Signaling 1,07E00 2E-01 NRAS,MAPK1,TFDP1,GRB2,SUV39H1,KRAS, CCND1,SIN3A,PTEN,BCL2,HSP90B1,CCNE1,F OXO1,CHUK,CDKN1B,MAP2K1 140 Citrulline Biosynthesis 1,05E00 3,75E-01 GLS,OAT,ARG2 141 Glutathione-mediated 1,04E00 2,61E-01 MGST2,GSTM5,GSTM3,GSTM4,HPGDS,ANP Detoxification EP 142 TREM1 Signaling 1,03E00 2,03E-01 3,207 CXCL3,STAT5A,CXCL8,NLRP3,MAPK1,TYROB P,MYD88,IL10,GRB2,IL1B,STAT3,FCGR2B,TN F,IRAK1 143 Role of Pattern 1,02E00 1,86E-01 2,138 PTX3,CXCL8,IL1A,OAS1,C5AR1,NLRP3,MAPK Recognition Receptors in 1,OAS2,IL17C,IL10,MYD88,C1QA,C1QC,C1Q B,C5,IL17D,DDX58,MAPK10,MAVS,IL1B,TNF Recognition of Bacteria ,C3AR1 and Viruses 144 Differential Regulation of 1,02E00 2,78E-01 CCL4,IL10,IL1B,CXCL1,TNF Cytokine Production in Macrophages and T Helper Cells by IL-17A and IL-17F

145 p38 MAPK Signaling 1,02E00 1,88E-01 0,447 IL1A,MAPKAPK3,PLA2G4C,RPS6KA3,MAPKA PK5,IRAK3,MKNK2,MAP3K5,FAS,IRAK1,TGF BR2,PLA2G4A,PLA2G6,IL1RN,DUSP10,MEF2 D,MKNK1,IL1B,STAT1,TNF,IRAK4

146 Role of IL-17A in Psoriasis 1,02E00 3,08E-01 CXCL8,CXCL3,CXCL1,IL17RA

147 Cholesterol Biosynthesis I 1,02E00 3,08E-01 FDFT1,LSS,TM7SF2,SC5D

148 Cholesterol Biosynthesis 1,02E00 3,08E-01 FDFT1,LSS,TM7SF2,SC5D II (via 24,25- dihydrolanosterol)

149 Cholesterol Biosynthesis 1,02E00 3,08E-01 FDFT1,LSS,TM7SF2,SC5D III (via Desmosterol)

150 Retinoate Biosynthesis II 1,02E00 5E-01 RBP7,RBP1

151 Pentose Phosphate 1,02E00 5E-01 PGLS,G6PD Pathway (Oxidative Branch) 152 Branched-chain α-keto 1,02E00 5E-01 BCKDHA,BCKDHB acid Dehydrogenase Complex

153 Eumelanin Biosynthesis 1,02E00 5E-01 MIF,DDT

154 Methylmalonyl Pathway 1,02E00 5E-01 PCCB,MUT

155 Biotin-carboxyl Carrier 1,02E00 5E-01 ACACB,ACACA Protein Assembly 156 Ceramide Degradation 1,02E00 5E-01 NAAA,ASAH1 157 Arginine Degradation I 1,02E00 5E-01 OAT,ARG2 (Arginase Pathway) 158 Type I Diabetes Mellitus 1,01E00 1,9E-01 SOCS1,MAP2K7,MAPK1,MYD88,IFNGR2,MA Signaling P3K5,FAS,IRAK1,BCL2,IKBKB,FCER1G,MAPK 10,BID,IL1B,CHUK,STAT1,TNF,SOCS5,TNFRS F11B 159 G Beta Gamma Signaling 9,95E-01 1,93E-01 GNAS,NRAS,CAV2,MAPK1,GRB2,GNA12,GN G2,GNB2L1,KRAS,GNA14,GNG7,PRKAG1,GN B1,GNA15,CAV1,GNA13,GNG12

160 Relaxin Signaling 9,82E-01 1,82E-01 GNAS,MAPK1,PDE12,PDE3A,GNA12,GNG2, GNB2L1,GNA14,PDE4B,PRKAG1,GNG7,VEGF A,GNB1,BRAF,JUN,GNA15,NPR1,PDE1B,GN A13,MAP2K1,ADCY7,APEX1,MMP9,GNG12

161 CXCR4 Signaling 9,82E-01 1,79E-01 1,706 MAPK1,CD4,GNB2L1,CRK,KRAS,GNA14,GNG 7,GNB1,JUN,RHOB,GNA15,GNA13,MAP2K1, GNG12,MYL12A,GNAS,NRAS,GNA12,EGR1, GNG2,RAC1,RHOQ,RHOA,LYN,MAPK10,ADC Y7,FNBP1 162 Cell Cycle Regulation by 9,75E-01 2,29E-01 PPP2R1A,CCNE1,CNOT7,PPP2R5D,PPM1L,B BTG Family Proteins TG2,PPP2R5C,CCND1

163 Gαq Signaling 9,72E-01 1,79E-01 2,041 HTR2B,MAPK1,GNB2L1,GNA14,GNG7,GNB1 ,HRH1,HMOX1,IKBKB,RHOB,GNA15,PPP3R1 ,GPLD1,CHUK,MAP2K1,GNG12,PPP3CA,GNA S,GNG2,CHP1,PLD1,CALM1 (includes others),RHOQ,RHOA,NFATC2,FNBP1

164 Superpathway of D-myo- 9,67E-01 2,5E-01 MINPP1,IMPAD1,SYNJ1,INPPL1,PMPCA,PTE inositol (1,4,5)- N trisphosphate Metabolism 165 Hepatic Cholestasis 9,66E-01 1,77E-01 PPARA,IL1A,IL17C,HNF1A,PRKAG1,IRAK1,CE TP,IKBKB,JUN,ABCC1,IL17D,CHUK,TNFRSF11 B,CXCL8,GNAS,TJP2,MYD88,IRAK3,SLCO3A1 ,IL1RN,MAPK10,IL1B,CD14,INSR,RXRA,TNF, ADCY7,IRAK4 166 Role of 9,6E-01 2,2E-01 CCR1,CXCL8,IL1A,CCR5,CCL4,IL1RN,IL15,IL1 Hypercytokinemia/hyper B,TNF chemokinemia in the Pathogenesis of Influenza

167 Role of IL-17F in Allergic 9,6E-01 2,2E-01 CXCL8,CCL4,IGF1,MAPK1,RPS6KA3,IL1B,CXC Inflammatory Airway L1,IL17RA,MAP2K1 Diseases 168 FLT3 Signaling in 9,47E-01 1,97E-01 STAT4,GAB2,STAT5A,NRAS,PTPN11,MAPK1, Hematopoietic GRB2,RPS6KA3,KRAS,STAT3,STAT1,MAP2K1 ,EIF4E,EIF4EBP1 Progenitor Cells 169 Small Cell Lung Cancer 9,47E-01 1,97E-01 TFDP1,SUV39H1,CCND1,CDKN2B,SIN3A,PTE Signaling N,BCL2,IKBKB,CCNE1,BID,CHUK,CDKN1B,RX RA,RXRB 170 D-myo-inositol (1,3,4)- 9,39E-01 2,63E-01 MINPP1,SYNJ1,INPPL1,PMPCA,PTEN trisphosphate Biosynthesis 171 Retinoate Biosynthesis I 9,37E-01 2,33E-01 DHRS3,RBP7,AKR1C3,RDH10,ALDH1A3,ADH 1C,RBP1 172 RhoGDI Signaling 9,37E-01 1,74E-01 -1,964 PPP1R12C,ARHGEF7,ARPC5,GNB2L1,GNA14 ,GNG7,GNB1,ACTR3,PPP1R12A,RHOB,GNA1 5,EZR,GNA13,GNG12,MYL12A,ARHGEF4,GN AS,ARHGEF12,ARPC5L,GNA12,GNG2,RAC1, ARPC1A,RHOQ,RHOA,ARPC2,ARHGEF10,PIP 4K2A,FNBP1,MSN

173 Cdc42 Signaling 9,36E-01 1,82E-01 0,832 MAPK1,ARPC5L,ARPC5,PPP1CB,EXOC6,IQG AP1,CLIP1,IQGAP2,ARPC1A,ACTR3,JUN,PPP 1R12A,ARPC2,MAPK10,EXOC2,FCER1G,VAV 1,CDC42SE1,EXOC3,PARD3,FNBP1L,MYL12A

174 Telomerase Signaling 9,34E-01 1,88E-01 2,309 HDAC9,NRAS,MAPK1,GRB2,PPP2R5D,TERF2 IP,DKC1,KRAS,PTGES3,ELF1,PPP2R1A,HSP90 B1,HDAC3,SP1,PPM1L,TPP1,PPP2R5C,MAP2 K1 175 Pathogenesis of Multiple 9,22E-01 3,33E-01 CCR1,CCR5,CCL4 Sclerosis 176 Oleate Biosynthesis II 9,22E-01 3,33E-01 CYB5A,ALDH6A1,FADS1 (Animals) 177 Colanic Acid Building 9,19E-01 2,86E-01 GPI,UGDH,PMM1,MPI Blocks Biosynthesis 178 Granulocyte Adhesion 9,16E-01 1,75E-01 CD99,FPR3,IL1A,SDC4,CXCL3,HRH1,CCL13,E and Diapedesis ZR,CXCL1,CCL19,TNFRSF11B,CXCL8,SELE,C5 AR1,CKLF,THY1,C5,ITGB2,CXCL16,ITGAM,CL DN23,CCL4,IL1RN,IL1B,CCL18,TNF,MMP9,M SN 179 UVC-Induced MAPK 9,09E-01 2,14E-01 1,000 BRAF,JUN,NRAS,MAPK1,MAPK10,KRAS,ATR, Signaling SMPD1,MAP2K1 180 CNTF Signaling 9,04E-01 2,08E-01 2,530 NRAS,PTPN11,MAPK1,GRB2,CNTFR,RPS6KA 3,KRAS,STAT3,STAT1,MAP2K1 181 Role of JAK1 and JAK3 in 9,04E-01 2E-01 SOCS1,STAT5A,NRAS,PTPN11,MAPK1,GRB2, γc Cytokine Signaling IRS1,IL15,IRS2,KRAS,STAT3,STAT1

182 Neuregulin Signaling 8,87E-01 1,88E-01 2,496 STAT5A,NRAS,MAPK1,GRB2,CRK,KRAS,PTEN ,RPS6,HSP90B1,PTPN11,ERRFI1,CDKN1B,ER EG,MAP2K1,RNF41,PSEN1 183 α-Adrenergic Signaling 8,87E-01 1,88E-01 0,905 GNAS,NRAS,MAPK1,GNG2,GNB2L1,KRAS,PH KA2,GNG7,PRKAG1,GNB1,CALM1 (includes others),PYGM,MAP2K1,ADCY7,GNG12,PHK G1

184 HIPPO signaling 8,87E-01 1,88E-01 -0,333 TEAD4,SAV1,TJP2,YWHAH,FAT4,PPP2R5D,P PP1R3C,PPP1CB,PPP1R14A,CSNK1E,PPP2R1 A,DLG5,PPP1R12A,PPM1L,PPP2R5C,PARD3

185 4-1BB Signaling in T 8,79E-01 2,26E-01 0,378 IKBKB,JUN,MAPK1,MAPK10,CHUK,MAP3K5, Lymphocytes MAP2K1 186 G Protein Signaling 8,79E-01 2,26E-01 GNB1,GNAS,GNB2L1,GNG2,INSR,GNG12,GN Mediated by Tubby G7 187 MIF-mediated 8,79E-01 2,26E-01 1,890 PLA2G6,PLA2G4A,MIF,MAPK1,PLA2G4C,CD Glucocorticoid Regulation 14,NR3C1

188 Superpathway of 8,79E-01 2,26E-01 PRMT3,MGMT,PCCB,MTR,CTH,MUT,BHMT Methionine Degradation 2 189 T Helper Cell 8,64E-01 1,97E-01 STAT4,TGFBR2,IL10,IL6R,IL10RA,IFNGR2,FC Differentiation ER1G,STAT3,STAT1,BCL6,TNF,TNFRSF11B 190 ERK5 Signaling 8,64E-01 1,97E-01 1,508 NRAS,PTPN11,YWHAH,GAB1,SGK1,GNA12, MEF2D,FOXO3,RPS6KA3,KRAS,GNA13,MAP 2K5 191 Superpathway of Inositol 8,57E-01 1,7E-01 MINPP1,PPP1R12C,NUDT12,PPFIBP2,IPPK,I Phosphate Compounds GBP1,INPPL1,PTPN12,PTPRF,SACM1L,PTEN, PTPRC,PLCE1,PPP1R12A,DUSP10,IP6K1,IP6K 2,NUDT4,RNGTT,PPP3CA,PMPCA,PPFIA1,PT PN6,PPP1R8,PPP1R1B,PPP2R5D,PPP1R14A, PPP4R1,PTPN11,SYNJ1,PIP4K2A

192 Thio-molybdenum 8,55E-01 1E00 MOCOS Cofactor Biosynthesis 193 Thiamin Salvage III 8,55E-01 1E00 TPK1 194 Glutamine Biosynthesis I 8,55E-01 1E00 GLUL

195 Methylglyoxal 8,55E-01 1E00 LDHD Degradation VI 196 L-cysteine Degradation II 8,55E-01 1E00 CTH

197 Asparagine Biosynthesis I 8,55E-01 1E00 ASNS

198 Phosphatidylethanolamin 8,55E-01 1E00 PTDSS2 e Biosynthesis III 199 Lanosterol Biosynthesis 8,55E-01 1E00 LSS

200 D-mannose Degradation 8,55E-01 1E00 MPI

201 RhoA Signaling 8,43E-01 1,78E-01 1,606 PLXNA1,SEPT8,ARHGEF12,ARPC5L,GNA12,A RPC5,PPP1CB,CDC42EP4,PLD1,ARPC1A,ACT R3,IGF1,ABL2,PPP1R12A,EZR,ARPC2,RHOA, GNA13,PIP4K2A,MSN,MYL12A

202 Serine Biosynthesis 8,35E-01 4E-01 PSAT1,PHGDH 203 NAD Salvage Pathway III 8,35E-01 4E-01 NMRK1,NMNAT3

204 2-oxobutanoate 8,35E-01 4E-01 PCCB,MUT Degradation I 205 dTMP De Novo 8,35E-01 4E-01 SHMT1,SHMT2 Biosynthesis 206 Glutamate Degradation 8,35E-01 4E-01 SUCLG2,ABAT III (via 4-aminobutyrate)

207 Acetate Conversion to 8,35E-01 4E-01 ACSS3,ACSS2 Acetyl-CoA 208 Hereditary Breast Cancer 8,33E-01 1,79E-01 POLR2I,HDAC9,UBB,NRAS,GADD45B,GADD4 Signaling 5G,POLR2K,RFC1,KRAS,POLR2B,CCND1,PTE N,HDAC3,POLR2C,GADD45A,XPC,SLC19A1,A TR,UBC,HLTF 209 The Visual Cycle 8,33E-01 2,67E-01 DHRS3,RBP7,RDH10,RBP1 210 Oxidative Ethanol 8,33E-01 2,67E-01 ALDH2,ACSS3,ALDH1A3,ACSS2 Degradation III 211 Chemokine Signaling 8,32E-01 1,91E-01 1,387 CALM1 (includes others),CCR5,CCL4,CCL13,JUN,CAMK1,NRAS ,PPP1R12A,MAPK1,RHOA,PPP1CB,KRAS,MA P2K1 212 Noradrenaline and 8,24E-01 2,19E-01 HSD17B10,ALDH2,ADH1A,ALDH1A3,ADH1C, Adrenaline Degradation ADH1B,ADHFE1

213 Tight Junction Signaling 8,23E-01 1,71E-01 CPSF2,MYH10,NAPG,VTI1B,PRKAG1,SMURF 1,PTEN,TGFBR2,NSF,MPDZ,JUN,PPM1L,PPP 2R5C,NAPA,VASP,TNFRSF11B,TJP2,PPP2R5 D,RAC1,CNKSR3,F11R,PPP2R1A,CLDN23,NU DT21,RHOA,MAGI2,CSTF3,TNF

214 Acyl-CoA Hydrolysis 8,13E-01 3E-01 PPT1,GNPAT,THEM4 215 Pentose Phosphate 8,13E-01 3E-01 TKT,PGLS,G6PD Pathway 216 Methylglyoxal 8,13E-01 3E-01 AKR1C1/AKR1C2,AKR1C3,AKR1B1 Degradation III 217 Glycine Betaine 8,13E-01 3E-01 SHMT1,BHMT2,SHMT2 Degradation 218 Systemic Lupus 8,03E-01 1,69E-01 IL1A,MAPK1,PRPF8,KRAS,FCGR2B,SART1,PT Erythematosus Signaling PRC,JUN,SNRPD2,PRPF31,FCGR3A/FCGR3B, TNFSF13B,SNRPA,LSM6,PTPN6,NRAS,IL10,G RB2,IL6R,C5,IL1RN,CD72,SNRPB2,LYN,FCER 1G,SNRNP70,NFATC2,IL1B,C6,TNF

219 Glioma Signaling 8,02E-01 1,81E-01 1,732 CAMK1,NRAS,MAPK1,TFDP1,GRB2,PDGFA,S UV39H1,CDKN2C,KRAS,PDGFC,CCND1,CDKN 2B,SIN3A,PTEN,CALM1 (includes others),IGF1,MAP2K1 220 Renal Cell Carcinoma 7,97E-01 1,88E-01 1,897 VEGFA,UBB,JUN,NRAS,GAB1,PTPN11,MAPK Signaling 1,GRB2,RAC1,KRAS,CRK,UBC,MAP2K1 221 NAD Salvage Pathway II 7,96E-01 2,38E-01 NT5C3A,NMRK1,ACP6,NUDT12,NMNAT3

222 PKCθ Signaling in T 7,95E-01 1,78E-01 FYN,NRAS,MAPK1,GRB2,CD4,CHP1,RAC1,KR Lymphocytes AS,MALT1,MAP3K5,IKBKB,JUN,PPP3R1,FCE R1G,NFATC2,VAV1,CHUK,LCP2,PPP3CA

223 Apoptosis Signaling 7,92E-01 1,82E-01 -1,807 MAP2K7,NRAS,MAPK1,KRAS,MAP3K5,FAS,B CL2,ACIN1,IKBKB,BID,HTRA2,CHUK,BCL2A1, MAP4K4,TNF,MAP2K1 224 Huntington's Disease 7,86E-01 1,64E-01 SDHB,MAPK1,SGK1,GNB2L1,HSPA1A/HSPA1 Signaling B,NAPG,GNA14,POLR2B,HSPA5,VTI1B,GNG 7,GNB1,NSF,POLR2C,JUN,GNA15,SP1,IGF1, DNAJB1,NAPA,GNG12,POLR2I,HDAC9,MAP2 K7,UBB,GRB2,RCOR3,GLS,CLTC,IFT57,GNG2, POLR2K,SIN3A,HDAC3,ATP5B,DCTN1,UBC

225 14-3-3-mediated 7,8E-01 1,75E-01 TSC1,NRAS,YWHAH,MAPK1,GRB2,TUBB2A, Signaling KRAS,MAP3K5,TUBB,TUBB2B,JUN,PLCE1,FO XO1,TSC2,MAPK10,CDKN1B,PDCD6IP,TNF, MAP2K1,AKT1S1 226 CD27 Signaling in 7,77E-01 1,96E-01 IKBKB,MAP2K7,SIVA1,JUN,MAPK10,BID,CH Lymphocytes UK,MAP3K5,MAP2K1,MAP2K5 227 MIF Regulation of Innate 7,71E-01 2,05E-01 0,707 PLA2G6,PLA2G4A,MIF,JUN,MAPK1,PLA2G4 Immunity C,MAPK10,CD14 228 VEGF Signaling 7,63E-01 1,8E-01 0,000 PTPN6,EIF2B4,NRAS,MAPK1,GRB2,KRAS,EIF 2S3,PDGFC,BCL2,VEGFA,EIF1,PTPN11,FOXO 1,FOXO3,MAP2K1,EIF1AX 229 Thrombin Signaling 7,53E-01 1,66E-01 1,706 CAMK1,MAPK1,F2R,GNB2L1,PPP1CB,KRAS, GNA14,GNG7,GNB1,IKBKB,PLCE1,GNA15,R HOB,PPP1R12A,GATA6,GNA13,MAP2K1,GN G12,MYL12A,ARHGEF4,GNAS,ARHGEF12,NR AS,GRB2,GNA12,GNG2,RHOQ,RHOA,ARHGE F10,ADCY7,FNBP1

230 Eicosanoid Signaling 7,46E-01 1,9E-01 0,378 PLA2G16,PLA2G6,PLA2G4A,PTGFR,LTA4H,A KR1C3,PLA2G4C,CYSLTR1,ALOX5AP,HPGDS, PRDX6 231 Glycolysis I 7,34E-01 2,27E-01 PGK1,GPI,TPI1,PKM,PFKL 232 PEDF Signaling 7,31E-01 1,83E-01 0,832 PPARG,HNF1B,IKBKB,NRAS,MAPK1,RHOA,R AC1,KRAS,CHUK,HNF1A,PNPLA2,FAS,BCL2

233 B Cell Activating Factor 7,27E-01 2E-01 0,707 IKBKB,MAP2K7,JUN,MAPK1,MAPK10,NFATC Signaling 2,CHUK,TNFSF13B 234 IL-9 Signaling 7,24E-01 2,06E-01 0,000 STAT5A,IRS1,CISH,IRS2,STAT3,STAT1,TNF

235 Interferon Signaling 7,24E-01 2,06E-01 1,890 IFIT3,SOCS1,IFIT1,OAS1,IFNGR2,STAT1,BCL2

236 Non-Small Cell Lung 7,21E-01 1,85E-01 2,646 NRAS,TFDP1,MAPK1,GRB2,SUV39H1,FOXO3 Cancer Signaling ,KRAS,RXRB,RXRA,CCND1,MAP2K1,SIN3A 237 iCOS-iCOSL Signaling in T 7,19E-01 1,75E-01 2,324 GAB2,GRB2,CD4,CHP1,RAC1,PTEN,PTPRC,IK Helper Cells BKB,CALM1 (includes others),PPP3R1,FCER1G,NFATC2,VAV1,PLEK HA1,CHUK,LCP2,PPP3CA 238 Arginine Degradation VI 7E-01 3,33E-01 OAT,ARG2 (Arginase 2 Pathway)

239 Thioredoxin Pathway 7E-01 3,33E-01 TXN,TXNRD1 240 Serotonin Degradation 6,93E-01 1,91E-01 HSD17B10,ALDH2,ADH1A,ALDH1A3,SULT1A 1,ADH1C,ADH1B,CSGALNACT1,ADHFE1

241 Granzyme A Signaling 6,87E-01 2,35E-01 H1FX,HMGB2,H1F0,APEX1 242 Ethanol Degradation IV 6,87E-01 2,35E-01 ALDH2,ACSS3,ALDH1A3,ACSS2

243 NF-κB Signaling 6,85E-01 1,65E-01 1,732 IL1A,TNFAIP3,KRAS,IRAK1,BRAF,TGFBR2,IKB KB,CSNK2A1,CSNK2B,CHUK,TNFSF13B,TNFR SF11B,MAP2K7,NRAS,MYD88,RELB,MALT1,I RAK3,CSNK2A2,GHR,IL1RN,FCER1G,IL1B,INS R,MAP4K4,TNF,IRAK4

244 IL-17A Signaling in 6,79E-01 2E-01 IKBKB,JUN,MAPK1,CEBPD,CHUK,CEBPB,IL17 Fibroblasts RA 245 tRNA Splicing 6,79E-01 2E-01 TSEN15,PDE12,PDE3A,PDE1B,TRPT1,PDE4B, APEX1 246 Nucleotide Excision 6,79E-01 2E-01 POLR2I,POLR2C,XPC,GTF2H5,POLR2K,POLR Repair Pathway 2B,XPA 247 3-phosphoinositide 6,67E-01 1,66E-01 PPFIA1,PTPN6,PPP1R12C,PPP1R8,PPP1R1B, Biosynthesis PPP2R5D,NUDT12,PPFIBP2,PPP1R14A,IGBP 1,PPP4R1,PTPN12,PTPRF,PTEN,SACM1L,PTP RC,SYNJ1,PTPN11,PPP1R12A,DUSP10,NUDT 4,RNGTT,PIP4K2A,PPP3CA 248 Synaptic Long Term 6,63E-01 1,67E-01 0,426 PLA2G16,NRAS,GNAS,MAPK1,GNA12,PPP2R Depression 5D,PLA2G4C,KRAS,GNA14,PRDX6,PLA2G6,P LA2G4A,PPP2R1A,PLCE1,IGF1,GNA15,NPR1, PPM1L,LYN,PPP2R5C,GNA13,MAP2K1

249 Neurotrophin/TRK 6,58E-01 1,79E-01 0,000 MAP2K7,JUN,NRAS,PTPN11,SPRY1,MAPK1, Signaling GAB1,GRB2,KRAS,MAP3K5,MAP2K1,MAP2K 5 250 Retinol Biosynthesis 6,29E-01 2E-01 DHRS3,RBP7,RDH10,PNPLA2,RBP1,ESD 251 GDNF Family Ligand- 6,28E-01 1,76E-01 0,577 DOK5,JUN,NRAS,MAPK1,GAB1,GRB2,IRS1, Receptor Interactions MAPK10,RAC1,IRS2,KRAS,MAP2K1 252 D-myo-inositol (1,4,5)- 6,25E-01 2,22E-01 IMPAD1,SYNJ1,INPPL1,PMPCA trisphosphate Degradation 253 IL-22 Signaling 6,24E-01 2,08E-01 0,447 STAT5A,MAPK1,MAPK10,STAT3,STAT1 254 Tumoricidal Function of 6,24E-01 2,08E-01 M6PR,SRGN,BID,LYVE1,FAS Hepatic Natural Killer Cells 255 Role of JAK1, JAK2 and 6,24E-01 2,08E-01 0,000 SOCS1,PTPN6,IFNGR2,STAT3,STAT1 TYK2 in Interferon Signaling 256 EGF Signaling 6,01E-01 1,79E-01 0,000 CSNK2A2,MAP2K7,JUN,MAPK1,GRB2,CSNK2 A1,CSNK2B,STAT3,STAT1,MAP2K1 257 Axonal Guidance 6E-01 1,52E-01 SLIT3,KLC1,MAPK1,ARPC5,GNB2L1,KRAS,TU Signaling BB,ADAMTS2,VEGFA,GNB1,PLCE1,GNA15,P PP3R1,SRGAP2,GNA13,ADAMTS5,GNG12,G NG2,TUBB2A,RAC1,ARPC1A,PTPN11,ADAM 12,RHOA,ARPC2,FYN,ERAP2,RGS3,PDGFA,A RHGEF7,SEMA6A,EPHA4,CRK,GNA14,PDGFC ,ROBO1,EIF4E,GNG7,PRKAG1,TUBB2B,ACTR 3,IGF1,GLIS1,MKNK1,PSMD14,MAP2K1,PPP 3CA,VASP,MYL12A,PLXNA1,SEMA3G,NRAS, ARHGEF12,GNAS,GRB2,ARPC5L,GNA12,CHP 1,SLIT2,NFATC2,SEMA3C,ADAM9,WNT11,M MP9

258 Growth Hormone 5,99E-01 1,74E-01 0,000 SOCS1,STAT5A,PTPN6,GHR,IGF1,MAPK1,IRS Signaling 1,RPS6KA3,STAT3,STAT1,SLC2A4,SOCS5 259 HER-2 Signaling in Breast 5,87E-01 1,71E-01 ITGB2,TSC1,CCNE1,NRAS,FOXO1,GRB2,TSC2 Cancer ,KRAS,CDKN1B,MAP3K5,PARD3,CCND1,ITG B5 260 Pyridoxal 5'-phosphate 5,85E-01 1,75E-01 PDXK,BRAF,FAM20B,CDK8,MAPK1,SGK1,GR Salvage Pathway K6,MAPK6,HIPK1,MAP2K1,IRAK1

261 Hypoxia Signaling in the 5,85E-01 1,75E-01 VEGFA,HSP90B1,JUN,UBE2A,UBE2R2,NQO1 Cardiovascular System ,SLC2A4,UBE2F,UBE2J2,PTEN,UBE2I

262 Epoxysqualene 5,85E-01 5E-01 FDFT1 Biosynthesis 263 Guanine and Guanosine 5,85E-01 5E-01 HPRT1 Salvage I 264 Lipoate Biosynthesis and 5,85E-01 5E-01 LIAS Incorporation II 265 Alanine Degradation III 5,85E-01 5E-01 GPT2 266 Taurine Biosynthesis 5,85E-01 5E-01 CSAD 267 Flavin Biosynthesis IV 5,85E-01 5E-01 RFK (Mammalian) 268 Alanine Biosynthesis II 5,85E-01 5E-01 GPT2 269 Palmitate Biosynthesis I 5,85E-01 5E-01 FASN (Animals)

270 L-cysteine Degradation III 5,85E-01 5E-01 MPST

271 Thiosulfate 5,85E-01 5E-01 TST Disproportionation III (Rhodanese) 272 Fatty Acid Biosynthesis 5,85E-01 5E-01 FASN Initiation II

273 Cysteine 5,85E-01 5E-01 CTH Biosynthesis/Homocystei ne Degradation 274 Cardiolipin Biosynthesis II 5,85E-01 5E-01 PTPMT1

275 Formaldehyde Oxidation 5,85E-01 5E-01 ESD II (Glutathione- dependent)

276 Glutamine Degradation I 5,85E-01 5E-01 GLS

277 Aldosterone Signaling in 5,71E-01 1,6E-01 CRYAB,DNAJB12,MAPK1,SGK1,DNAJB4,HSP Epithelial Cells A1A/HSPA1B,DNAJC19,HSPB8,DNAJC3,DNA JC10,KRAS,DNAJB2,HSPA5,DNAJC11,HSP90 B1,PLCE1,DNAJB11,HSPA13,HSPB11,DNAJB 6,DNAJB1,DNAJC30,MAP2K1,PIP4K2A

278 Choline Biosynthesis III 5,69E-01 2,31E-01 HMOX1,GPLD1,PLD1

279 1D-myo-inositol 5,69E-01 2,11E-01 SYNJ1,IPPK,INPPL1,PMPCA Hexakisphosphate Biosynthesis II (Mammalian) 280 Dopamine Receptor 5,61E-01 1,69E-01 -0,707 GNAS,PPP1R1B,PPP2R5D,PPP1R3C,PPP1R1 Signaling 4A,PPP1CB,PRKAG1,PPP2R1A,PPP1R12A,PP M1L,PPP2R5C,PCBD1,ADCY7 281 April Mediated Signaling 5,59E-01 1,84E-01 0,378 IKBKB,MAP2K7,JUN,MAPK1,MAPK10,NFATC 2,CHUK 282 Phospholipases 5,55E-01 1,76E-01 PLA2G16,HMOX1,PLA2G6,PLA2G4A,PLCE1, GPLD1,PLA2G4C,PLD1,PRDX6 283 FXR/RXR Activation 5,54E-01 1,61E-01 PPARG,PPARA,APOE,MLXIPL,IL1A,APOB,VL DLR,HNF1A,CETP,TF,FOXO1,IL1RN,FASN,MA PK10,IL1B,RXRA,TNF,CLU,RBP4,AGT

284 Caveolar-mediated 5,46E-01 1,69E-01 ITGB2,COPZ1,FYN,ITGAM,ITGAV,CAV1,CD48 Endocytosis Signaling ,INSR,COPB2,COPB1,PTRF,ITGB5 285 CCR3 Signaling in 5,45E-01 1,62E-01 GNAS,NRAS,MAPK1,GNG2,PLA2G4C,GNB2L Eosinophils 1,RAC1,PPP1CB,KRAS,GNG7,GNB1,PLA2G4A ,CALM1 (includes others),PLA2G6,PPP1R12A,RHOA,MAP2K1, GNG12 286 Molecular Mechanisms of 5,34E-01 1,51E-01 GAB2,MAPK1,SUV39H1,NCSTN,CDKN2C,KR Cancer AS,CCND1,TGFBR2,GNA15,RHOB,GNA13,RA LGDS,ARHGEF4,TFDP1,RAC1,RHOQ,CCND2, GAB1,PTPN11,RHOA,IRS1,APH1A,MAPK10, ARHGEF10,FNBP1,FYN,RAP2A,ARHGEF7,CR K,GNA14,MAP3K5,CDKN2B,FAS,PRKAG1,BC L2,BRAF,JUN,NLK,BID,MAP2K1,PMAIP1,GN AS,ARHGEF12,NRAS,GRB2,GNA12,SIN3A,CC NE1,FOXO1,ATR,CDKN1B,ADCY7,WNT11,PS EN1

287 Natural Killer Cell 5,3E-01 1,62E-01 FYN,PTPN6,NRAS,MAPK1,LAIR1,TYROBP,GR Signaling B2,RAC1,KRAS,INPPL1,SYNJ1,PTPN11,FCER1 G,VAV1,MAP2K1,LCP2,FCGR3A/FCGR3B

288 Angiopoietin Signaling 5,3E-01 1,69E-01 0,000 IKBKB,STAT5A,ANGPT2,NRAS,GRB14,FOXO1 ,PTPN11,GRB2,CRK,KRAS,CHUK 289 Semaphorin Signaling in 5,25E-01 1,73E-01 FYN,PLXNA1,ARHGEF12,RHOQ,MAPK1,RHO Neurons B,RHOA,RAC1,FNBP1 290 Netrin Signaling 5,24E-01 1,79E-01 PPP3R1,CHP1,RAC1,NFATC2,PRKAG1,PPP3C A,ENAH 291 Ceramide Signaling 5,13E-01 1,65E-01 1,941 NRAS,PPP2R5D,KRAS,SMPD1,BCL2,PPP2R1 A,JUN,PPM1L,PPP2R5C,MAP2K1,TNF,NSMA F,TNFRSF11B 292 Reelin Signaling in 5,13E-01 1,65E-01 ITGB2,APOE,FYN,ARHGEF4,MAP2K7,ARHGE Neurons F12,LYN,MAPK10,HCK,PAFAH1B1,VLDLR,AR HGEF10,FGR 293 Superpathway of 5,08E-01 2,14E-01 GLS,OAT,ARG2 Citrulline Metabolism 294 γ-glutamyl Cycle 5,08E-01 2,14E-01 OPLAH,GGCT,ANPEP 295 Vitamin-C Transport 5,08E-01 2,14E-01 TXN,SLC2A4,TXNRD1 296 Phosphatidylethanolamin 5,08E-01 2,5E-01 PCYT2,CHKA e Biosynthesis II 297 Salvage Pathways of 5,08E-01 2,5E-01 TYMP,TK2 Pyrimidine Deoxyribonucleotides 298 Circadian Rhythm 5,08E-01 1,82E-01 CSNK1E,PER1,NR1D1,CRY2,PER2,GRINA Signaling 299 Regulation of Actin-based 5,06E-01 1,63E-01 1,604 RHOQ,ARPC1A,ACTR3,PPP1R12A,RHOB,ARP Motility by Rho C5L,RHOA,ARPC2,ARPC5,RAC1,PPP1CB,PIP4 K2A,FNBP1,MYL12A 300 Bladder Cancer Signaling 5,06E-01 1,63E-01 CXCL8,NRAS,TFDP1,MAPK1,FGF2,SUV39H1, KRAS,PDGFC,CCND1,SIN3A,FGF1,VEGFA,MA P2K1,MMP9 301 Colorectal Cancer 4,95E-01 1,52E-01 0,707 MAPK1,GNB2L1,KRAS,HNF1A,CCND1,PDGF Metastasis Signaling C,PRKAG1,GNG7,VEGFA,GNB1,BRAF,TGFBR 2,JUN,ARRB1,RHOB,STAT1,MAP2K1,RALGD S,GNG12,GNAS,NRAS,GRB2,GNG2,IL6R,RAC 1,TCF7L1,STAT3,RHOQ,RHOA,MAPK10,ADC Y7,TNF,FNBP1,MMP9,WNT11

302 Activation of IRF by 4,87E-01 1,67E-01 1,000 IKBKB,JUN,IL10,DDX58,MAPK10,MAVS,CHU Cytosolic Pattern K,STAT1,IFIT2,TNF Recognition Receptors 303 Ovarian Cancer Signaling 4,8E-01 1,56E-01 NRAS,MAPK1,TFDP1,SUV39H1,LHCGR,KRAS ,TCF7L1,PDGFC,CCND1,HNF1A,SIN3A,PRKA G1,BCL2,PTEN,VEGFA,BRAF,ARRB1,MAP2K1 ,MMP9,WNT11 304 Polyamine Regulation in 4,73E-01 1,9E-01 PPARG,SAT2,KRAS,OAZ3 Colon Cancer 305 Pyrimidine 4,73E-01 1,9E-01 RRM2B,CMPK1,DTYMK,NME6 Deoxyribonucleotides De Novo Biosynthesis I

306 Regulation of Cellular 4,69E-01 1,67E-01 1,890 CCNE1,NRAS,MAPK1,GRB2,EZR,KRAS,CAST, Mechanics by Calpain CDKN1B,CCND1 Protease 307 Agranulocyte Adhesion 4,67E-01 1,53E-01 CD99,MYH10,IL1A,FN1,SDC4,CXCL3,HRH1,C and Diapedesis CL13,EZR,CXCL1,CCL19,CXCL8,SELE,C5AR1,C KLF,C5,ITGB2,CXCL16,CLDN23,CCL4,IL1RN,IL 1B,CCL18,TNF,MMP9,MSN 308 Regulation of the 4,65E-01 1,53E-01 LOX,MAPK1,FGF2,TWIST1,NCSTN,KRAS,HNF Epithelial-Mesenchymal 1A,SMURF1,BRAF,TGFBR2,MAP2K1,MAP2K 7,NRAS,GRB2,EGR1,STAT3,TCF7L1,FGF1,DV Transition Pathway L2,PTPN11,GAB1,APH1A,RHOA,WNT11,MM P9,MAP2K5,PSEN1 309 Estrogen-Dependent 4,62E-01 1,64E-01 HSD17B10,STAT5A,JUN,NRAS,IGF1,SP1,MA Breast Cancer Signaling PK1,KRAS,CCND1,HSD17B8

310 PCP pathway 4,62E-01 1,64E-01 -1,414 DVL2,JUN,VANGL1,RHOA,MAPK10,RAC1,JU ND,JUNB,SDC4,WNT11 311 Macropinocytosis 4,56E-01 1,62E-01 2,236 ITGB2,NRAS,PDGFA,RHOA,ANKFY1,RAC1,CD Signaling 14,KRAS,CSF1R,PDGFC,ITGB5 312 Parkinson's Signaling 4,55E-01 2E-01 UCHL1,MAPK1,PARK7 313 Endothelin-1 Signaling 4,53E-01 1,52E-01 0,000 PLA2G16,NRAS,GNAS,MAPK1,GRB2,GNA12, PLA2G4C,MAPK6,KRAS,GNA14,PLD1,PRDX6, BRAF,PLA2G4A,PLA2G6,HMOX1,PLCE1,JUN, GAB1,GNA15,GPLD1,MAPK10,ECE1,GNA13, ADCY7 314 TNFR2 Signaling 4,53E-01 1,79E-01 IKBKB,JUN,TNFAIP3,CHUK,TNF 315 Glioblastoma Multiforme 4,43E-01 1,53E-01 2,236 TSC1,NRAS,MAPK1,GRB2,PDGFA,RAC1,KRA Signaling S,PDGFC,CCND1,PTEN,CCNE1,PLCE1,RHOQ, FOXO1,IGF1,RHOB,RHOA,TSC2,CDKN1B,MA P2K1,FNBP1,WNT11 316 Diphthamide 4,4E-01 3,33E-01 EEF2 Biosynthesis 317 D-glucuronate 4,4E-01 3,33E-01 DCXR Degradation I 318 Hypusine Biosynthesis 4,4E-01 3,33E-01 DHPS 319 1D-myo-inositol 4,4E-01 3,33E-01 IPPK Hexakisphosphate Biosynthesis V (from Ins(1,3,4)P3) 320 Tyrosine Biosynthesis IV 4,4E-01 3,33E-01 PCBD1

321 N-acetylglucosamine 4,4E-01 3,33E-01 AMDHD2 Degradation I 322 Assembly of RNA 4,38E-01 2,22E-01 POLR1D,TAF1B Polymerase I Complex 323 Prostanoid Biosynthesis 4,38E-01 2,22E-01 HPGDS,PTGES3

324 Glycogen Degradation II 4,38E-01 2,22E-01 PYGM,TYMP

325 Melanoma Signaling 4,31E-01 1,67E-01 BRAF,NRAS,MAPK1,KRAS,CCND1,MAP2K1,P TEN 326 IL-12 Signaling and 4,3E-01 1,53E-01 PPARG,APOE,APOB,MAPK1,MYD88,IL10,RA Production in B7A,CEBPB,STAT4,IKBKB,LYZ,JUN,MAPK10, CHUK,STAT1,RXRA,TNF,MAP2K1,CLU,RBP4 Macrophages 327 p70S6K Signaling 4,17E-01 1,53E-01 0,243 NRAS,YWHAH,MAPK1,F2R,EEF2,GRB2,PPP2 R5D,KRAS,PLD1,RPS6,PPP2R1A,PLCE1,IRS1, PPM1L,LYN,PPP2R5C,MAP2K1,AGT

328 Gαi Signaling 4,17E-01 1,53E-01 0,378 GNAS,NRAS,MAPK1,GRB2,NPY1R,GNG2,GN B2L1,KRAS,STAT3,PRKAG1,GNG7,GNB1,NPR 3,CAV1,ADORA1,ADCY7,GNG12,RALGDS

329 Role of NFAT in Cardiac 4,1E-01 1,49E-01 0,408 CAMK1,MAPK1,GNB2L1,KRAS,PRKAG1,GNG Hypertrophy 7,TGFBR2,GNB1,PLCE1,IGF1,PPP3R1,MAP2 K1,GNG12,PPP3CA,HDAC9,MAP2K7,GNAS,N RAS,GRB2,GNG2,CHP1,CALM1 (includes others),HDAC3,MEF2D,MAPK10,ADCY7

330 Glutathione Redox 4,07E-01 1,88E-01 MGST2,GPX4,PRDX6 Reactions I 331 Putrescine Degradation III 4,07E-01 1,88E-01 ALDH2,ALDH1A3,SAT2

332 Melanocyte 4,07E-01 1,55E-01 0,832 PTPN6,GNAS,NRAS,MAPK1,GRB2,RPS6KA3, Development and CRK,KRAS,PRKAG1,BCL2,PTPN11,MAP2K1,A DCY7 Pigmentation Signaling

333 Assembly of RNA 3,99E-01 1,6E-01 POLR2I,POLR2C,GTF2E1,GTF2H5,POLR2K,G Polymerase II Complex TF2F1,POLR2B,TAF13

334 CD40 Signaling 3,93E-01 1,56E-01 0,333 IKBKB,MAP2K7,JUN,MAPK1,MAPK10,TNFAI P3,STAT3,CHUK,MAP2K1,MAP2K5 335 IL-17A Signaling in Airway 3,93E-01 1,56E-01 IKBKB,CXCL3,MAPK1,MAPK10,CXCL1,STAT3, Cells CHUK,IL17RA,MAP2K1,PTEN 336 Sphingosine-1-phosphate 3,86E-01 1,51E-01 1,604 GNAS,MAPK1,PDGFA,GNA12,RAC1,SMPD1, Signaling PDGFC,ASAH1,NAAA,PLCE1,RHOQ,RHOB,RH OA,GNA13,ADCY7,FNBP1 337 NGF Signaling 3,86E-01 1,51E-01 2,500 NRAS,MAPK1,GRB2,RAC1,RPS6KA3,CRK,KR AS,SMPD1,MAP3K5,IKBKB,GAB1,PTPN11,R HOA,MAPK10,CHUK,MAP2K1 338 Gαs Signaling 3,86E-01 1,51E-01 0,535 GNAS,MAPK1,GNB2L1,GNG2,LHCGR,GNG7, PRKAG1,BRAF,GNB1,ADD3,ADRB1,HCK,MA P2K1,ADCY7,GNG12,ADRB2 339 Myc Mediated Apoptosis 3,73E-01 1,55E-01 NRAS,IGF1,YWHAH,GRB2,MAPK10,BID,KRA Signaling S,FAS,BCL2 340 IL-17 Signaling 3,71E-01 1,53E-01 CXCL8,JUN,NRAS,MAPK1,TIMP1,MAPK10,K RAS,CXCL1,CEBPB,IL17RA,MAP2K1 341 Communication between 3,71E-01 1,53E-01 CXCL8,IL1A,CCL4,IL10,IL1RN,CD4,IL15,FCER Innate and Adaptive 1G,IL1B,TNF,TNFSF13B Immune Cells 342 Gap Junction Signaling 3,71E-01 1,48E-01 NRAS,HTR2B,GNAS,MAPK1,GRB2,CSNK1G3, TUBB2A,KRAS,TUBB,PRKAG1,TUBB2B,CSNK 1E,PLCE1,ADRB1,SP1,NPR1,PPP3R1,CAV1,M AP2K1,ADCY7,MAP2K5,PPP3CA

343 RANK Signaling in 3,7E-01 1,51E-01 CALM1 (includes Osteoclasts others),IKBKB,MAP2K7,JUN,MAPK1,PPP3R1 ,CHP1,MAPK10,NFATC2,CHUK,MAP3K5,MA P2K1,PPP3CA 344 Xenobiotic Metabolism 3,66E-01 1,45E-01 FTL,IL1A,CAMK1,GSTM5,MAPK1,KRAS,MAP Signaling 3K5,PTGES3,HMOX1,HSP90B1,ALDH1L1,AL DH1A3,PPM1L,CHST3,GSTM4,PPP2R5C,MA P2K1,NFE2L2,CITED2,AHR,ALDH6A1,MAP2K 7,NRAS,GSTM3,PPP2R5D,MGMT,NQO1,ESD ,PPP2R1A,MGST2,SULT1A1,IL1B,NRIP1,RXR A,TNF,MAP2K5 345 γ-linolenate Biosynthesis 3,65E-01 1,76E-01 SLC27A2,CYB5A,FADS1 II (Animals)

346 Estrogen-mediated S- 3,59E-01 1,67E-01 CCNE1,TFDP1,CDKN1B,CCND1 phase Entry 347 Pyrimidine 3,59E-01 1,67E-01 CTPS2,CMPK1,CTPS1,NME6 Ribonucleotides Interconversion 348 Gα12/13 Signaling 3,55E-01 1,48E-01 1,698 MAP2K7,NRAS,MAPK1,F2R,GNA12,KRAS,M AP3K5,IKBKB,JUN,MEF2D,RHOA,MAPK10,V AV1,GNA13,CHUK,MAP2K1,MYL12A

349 Renin-Angiotensin 3,54E-01 1,48E-01 1,000 PTPN6,GNAS,NRAS,MAPK1,GRB2,RAC1,KRA Signaling S,STAT3,PRKAG1,JUN,MAPK10,STAT1,TNF, MAP2K1,ADCY7,AGT 350 Graft-versus-Host Disease 3,54E-01 1,58E-01 IL1A,IL1RN,FCER1G,IL1B,TNF,FAS Signaling 351 TGF-β Signaling 3,53E-01 1,49E-01 2,828 NRAS,MAPK1,GRB2,ACVR1,KRAS,HOXC9,SM URF1,BCL2,TGFBR2,JUN,SERPINE1,ACVR1C, MAP2K1 352 Calcium-induced T 3,53E-01 1,54E-01 0,378 CALM1 (includes Lymphocyte Apoptosis others),CD4,PPP3R1,MEF2D,CHP1,FCER1G, NFATC2,PPP3CA 353 Endometrial Cancer 3,53E-01 1,54E-01 NRAS,MAPK1,GRB2,FOXO3,KRAS,CCND1,M Signaling AP2K1,PTEN 354 LPS-stimulated MAPK 3,52E-01 1,51E-01 1,897 IKBKB,JUN,NRAS,MAPK1,MAPK10,RAC1,CD Signaling 14,KRAS,CHUK,MAP3K5,MAP2K1 355 Leptin Signaling in 3,52E-01 1,51E-01 GNAS,PLCE1,FOXO1,PTPN11,MAPK1,GRB2, Obesity PDE3A,STAT3,ADCY7,MAP2K1,PRKAG1 356 IL-15 Signaling 3,52E-01 1,52E-01 CXCL8,STAT5A,NRAS,MAPK1,IL15,KRAS,STA T3,MAP2K1,TNF,BCL2 357 Wnt/β-catenin Signaling 3,46E-01 1,45E-01 -2,183 SFRP4,UBB,FRZB,CSNK1G3,PPP2R5D,ACVR1 ,TCF7L1,HNF1A,CCND1,TGFBR2,CSNK1E,CS NK2A2,PPP2R1A,DVL2,JUN,NLK,PPM1L,CSN K2A1,PPP2R5C,CSNK2B,UBC,ACVR1C,WNT1 1,SOX5 358 Airway Inflammation in 3,44E-01 2,5E-01 TNF Asthma 359 Creatine-phosphate 3,44E-01 2,5E-01 CKB Biosynthesis 360 Heme Degradation 3,44E-01 2,5E-01 HMOX1 361 Spermine and Spermidine 3,44E-01 2,5E-01 SAT2 Degradation I

362 Phenylethylamine 3,44E-01 2,5E-01 ALDH2 Degradation I 363 Myo-inositol Biosynthesis 3,44E-01 2,5E-01 IMPAD1

364 Geranylgeranyldiphospha 3,44E-01 2,5E-01 COX10 te Biosynthesis 365 Rapoport-Luebering 3,44E-01 2,5E-01 MINPP1 Glycolytic Shunt 366 NAD Biosynthesis III 3,44E-01 2,5E-01 NMNAT3 367 N-acetylglucosamine 3,44E-01 2,5E-01 AMDHD2 Degradation II 368 Phenylalanine 3,44E-01 2,5E-01 PCBD1 Degradation I (Aerobic)

369 Molybdenum Cofactor 3,44E-01 2,5E-01 GPHN Biosynthesis 370 Synaptic Long Term 3,4E-01 1,47E-01 NRAS,MAPK1,PPP1R3C,CHP1,PPP1R14A,PP Potentiation P1CB,KRAS,GNA14,PRKAG1,GRINA,CALM1 (includes others),PLCE1,PPP1R12A,GNA15,PPP3R1,M AP2K1,PPP3CA 371 Glycogen Degradation III 3,3E-01 1,82E-01 PYGM,TYMP

372 Docosahexaenoic Acid 3,29E-01 1,54E-01 FOXO1,BID,IL1B,BCL2A1,PNPLA2,BCL2 (DHA) Signaling 373 Cysteine Biosynthesis III 3,28E-01 1,67E-01 PRMT3,MGMT,CTH (mammalia) 374 ILK Signaling 3,25E-01 1,44E-01 0,408 MYH10,FN1,MAPK1,PDGFC,CCND1,PTEN,VE GFA,PARVB,JUN,PPP1R12A,RHOB,PPM1L,P PP2R5C,IRS2,ITGB5,NACA,PPP2R5D,ITGB2,P PP2R1A,RHOQ,IRS1,RHOA,MAPK10,TNF,FN BP1,MMP9 375 Altered T Cell and B Cell 3,17E-01 1,47E-01 IL1A,IL10,IL1RN,RELB,IL15,FCER1G,IL1B,CH Signaling in Rheumatoid UK,TNF,TNFSF13B,FAS Arthritis 376 HGF Signaling 3,09E-01 1,44E-01 1,069 MAP2K7,NRAS,MAPK1,GRB2,RAC1,KRAS,ST AT3,MAP3K5,CCND1,ELF1,JUN,PTPN11,GAB 1,MAPK10,MAP2K1 377 TWEAK Signaling 3,03E-01 1,52E-01 2,236 IKBKB,BID,CHUK,BAG4,TNFRSF12A 378 Stearate Biosynthesis I 3,03E-01 1,52E-01 SLC27A2,PPT1,FASN,GNPAT,THEM4 (Animals) 379 Cytotoxic T Lymphocyte- 2,99E-01 1,54E-01 2,000 FCER1G,BID,FAS,BCL2 mediated Apoptosis of Target Cells

380 Antiproliferative Role of 2,99E-01 1,54E-01 TGFBR2,CCNE1,MAPK1,CDKN1B TOB in T Cell Signaling 381 Pyrimidine 2,99E-01 1,54E-01 CTPS2,CMPK1,CTPS1,NME6 Ribonucleotides De Novo Biosynthesis 382 PXR/RXR Activation 2,95E-01 1,45E-01 PPARA,FOXO1,FOXO3,CYP2A6 (includes others),INSR,RXRA,TNF,NR3C1,PRKAG1

383 Lipid Antigen 2,94E-01 1,58E-01 FCER1G,PSAP,CANX Presentation by CD1 384 Role of CHK Proteins in 2,92E-01 1,45E-01 0,447 PPP2R1A,PPP2R5D,PPM1L,MDC1,SLC19A1, Cell Cycle Checkpoint PPP2R5C,RFC1,ATR Control 385 Death Receptor Signaling 2,91E-01 1,43E-01 1,387 MAP2K7,MAP3K5,PARP9,FAS,BCL2,ACIN1,IK BKB,BID,HTRA2,CHUK,MAP4K4,TNFRSF10A, TNF 386 Ubiquinol-10 Biosynthesis 2,88E-01 1,67E-01 BCKDHA,BCKDHB (Eukaryotic)

387 Histamine Degradation 2,88E-01 1,67E-01 ALDH2,ALDH1A3

388 BER pathway 2,88E-01 1,67E-01 APEX1,XRCC1 389 VDR/RXR Activation 2,85E-01 1,43E-01 0,000 SP1,FOXO1,GADD45A,PDGFA,CSNK2A1,CD1 4,CEBPB,CDKN1B,RXRB,RXRA,NCOA3

390 FcγRIIB Signaling in B 2,84E-01 1,46E-01 1,342 NRAS,GRB2,MAPK10,LYN,KRAS,FCGR2B Lymphocytes 391 IL-4 Signaling 2,82E-01 1,43E-01 SOCS1,PTPN6,NRAS,SYNJ1,GRB2,IRS1,NFAT C2,KRAS,INPPL1,NR3C1 392 Hematopoiesis from 2,79E-01 1,47E-01 CXCL8,IL1A,IL10,CD4,FCER1G Pluripotent Stem Cells 393 Tetrahydrofolate Salvage 2,77E-01 2E-01 MTHFD1 from 5,10- methenyltetrahydrofolat e 394 CMP-N- 2,77E-01 2E-01 GNE acetylneuraminate Biosynthesis I (Eukaryotes) 395 Glycerol Degradation I 2,77E-01 2E-01 GK 396 Lysine Degradation II 2,77E-01 2E-01 AASS 397 Glutamate Receptor 2,74E-01 1,43E-01 GNB1,CALM1 (includes Signaling others),GLS,GNG2,GLUL,SLC1A1,GNG7,GRIN A 398 FGF Signaling 2,73E-01 1,41E-01 1,155 PTPN6,PTPN11,MAPK1,GAB1,GRB2,FGF2,R AC1,CRK,STAT3,MAP3K5,MAP2K1,FGF1

399 Cell Cycle Control of 2,73E-01 1,48E-01 MCM6,ORC5,ORC4,MCM7 Chromosomal Replication

400 Maturity Onset Diabetes 2,64E-01 1,5E-01 HNF1B,INSR,HNF1A of Young (MODY) Signaling 401 Dopamine Degradation 2,64E-01 1,5E-01 ALDH2,ALDH1A3,SULT1A1 402 Coagulation System 2,58E-01 1,43E-01 1,342 F2R,PLAUR,F13A1,PLAU,SERPINE1 403 Estrogen Biosynthesis 2,58E-01 1,43E-01 HSD17B10,AKR1C3,CYP2U1,CYP2A6 (includes others),HSD17B8 404 Chondroitin Sulfate 2,51E-01 1,54E-01 GM2A,HEXB Degradation (Metazoa)

405 Bile Acid Biosynthesis, 2,51E-01 1,54E-01 AKR1C1/AKR1C2,AKR1C3 Neutral Pathway 406 NAD Biosynthesis from 2- 2,26E-01 1,67E-01 NMNAT3 amino-3- carboxymuconate Semialdehyde 407 Arginine Biosynthesis IV 2,26E-01 1,67E-01 OAT

408 Proline Biosynthesis II 2,26E-01 1,67E-01 OAT (from Arginine) 409 Urea Cycle 2,26E-01 1,67E-01 ARG2 410 Pentose Phosphate 2,26E-01 1,67E-01 TKT Pathway (Non-oxidative Branch) 411 Superoxide Radicals 2,26E-01 1,67E-01 NQO1 Degradation 412 Adenine and Adenosine 2,26E-01 1,67E-01 HPRT1 Salvage III 413 Zymosterol Biosynthesis 2,26E-01 1,67E-01 TM7SF2

414 Glycogen Biosynthesis II 2,26E-01 1,67E-01 GYG2 (from UDP-D-Glucose)

415 DNA Double-Strand Break 2,2E-01 1,43E-01 LIG4,XRCC1 Repair by Non- Homologous End Joining

416 Leukotriene Biosynthesis 2,2E-01 1,43E-01 LTA4H,MGST2

417 Dermatan Sulfate 2,2E-01 1,43E-01 GM2A,HEXB Degradation (Metazoa)

418 Phenylalanine 2,2E-01 1,43E-01 ALDH2,SLC27A2 Degradation IV (Mammalian, via Side Chain) 419 Phosphatidylcholine 1,86E-01 1,43E-01 CHKA Biosynthesis I 420 Aspartate Degradation II 1,86E-01 1,43E-01 MDH2 Supplementary data S3B Adipose tissue - pathways analysis of the significantly changed transcripts in the heavier compared with their leaner co-twins Ingenuity Canonical -log(p- Ratio z-score Molecules Pathways value)

1 Oxidative 9,67E00 3,65E-01 SDHB,COX6C,COX5B,NDUFB5,COX8A,ATP5L,ATP5 Phosphorylation G2,NDUFB8,ATP5S,NDUFA1,NDUFA2,NDUFA5,ND UFB9,NDUFAB1,ATPAF1,ATP5I,COX4I1,NDUFA8,N DUFS4,NDUFB4,ATP5O,COX7C,NDUFV3,NDUFB1,N DUFS3,UQCRB,NDUFS5,ATP5C1,NDUFB11,ATP5B, NDUFA6,CYC1,UQCRC2,COX7A2,CYB5A

2 Mitochondrial 5,12E00 2,42E-01 SDHB,COX6C,COX5B,NDUFB5,COX8A,ATP5L,NCST Dysfunction N,NDUFB8,ATP5G2,ATP5S,NDUFA1,NDUFA2,NDUF A5,NDUFB9,NDUFAB1,ATPAF1,ATP5I,COX4I1,NDU FS4,NDUFA8,NDUFB4,ATP5O,COX7C,NDUFV3,NDU FB1,NDUFS3,UQCRB,NDUFS5,ATP5C1,NDUFB11,A TP5B,NDUFA6,TXN2,CYC1,UQCRC2,COX7A2,BACE2 ,CYB5A 3 Valine Degradation I 5,1E00 5,56E-01 HADHB,BCAT2,ABAT,HIBADH,BCKDHA,AUH,DBT,A LDH6A1,HADHA,BCKDHB 4 Triacylglycerol 4,38E00 3,94E-01 MOGAT1,AGPAT5,ABHD5,LPIN1,LCLAT1,PPAP2B,L Biosynthesis PCAT4,DBT,LPIN2,AGPAT9,AGPAT3,PPAP2A,ELOVL 6 5 Glutaryl-CoA 4,21E00 6,36E-01 HADHB,ACAT2,ACAT1,HADHA,HADH,GCDH,HSD17 Degradation B8 6 Ethanol Degradation II 3,47E00 3,67E-01 ADH1A,ACSS3,ALDH1A3,ACSS2,ADH1C,ACSS1,ADH 1B,PECR,ADHFE1,ACSL1,ALDH7A1 7 Ketogenesis 3,47E00 6E-01 HADHB,BDH1,ACAT2,ACAT1,HMGCL,HADHA 8 Ketolysis 3,44E00 7,14E-01 HADHB,BDH1,ACAT2,ACAT1,HADHA 9 Lysine Degradation II 3,08E00 8E-01 AASDH,AASDHPPT,AASS,ALDH7A1 10 Acetate Conversion to 3,08E00 8E-01 ACSS3,ACSS2,ACSS1,ACSL1 Acetyl-CoA 11 Fatty Acid β-oxidation I 2,96E00 3,45E-01 HADHB,SLC27A2,ECI2,AUH,ACADM,ECI1,ACSL1,HA DHA,HADH,HSD17B8 12 Estrogen Receptor 2,94E00 2,14E-01 TAF9,CCNH,NRAS,MED20,SOS2,PHB2,HRAS,PCK1,T Signaling AF7,GTF2A1,NR3C1,SMARCA4,TAF9B,PGR,CTBP1, H3F3A/H3F3B,TAF1,POLR2C,PCK2,MED15,GTF2E1, ERCC3,MAPK3,NCOA1,NRIP1,MAP2K1,PPARGC1A

13 Oleate Biosynthesis II 2,75E00 5,56E-01 UFSP2,UFSP1,CYB5A,ALDH6A1,FADS1 (Animals) 14 Leucine Degradation I 2,75E00 5,56E-01 BCAT2,AUH,HMGCL,ACADM,MCCC2 15 Choline Biosynthesis III 2,69E00 4,62E-01 HMOX1,NAPEPLD,CEPT1,GPLD1,CHPT1,PLD1

16 Unfolded protein 2,63E00 2,64E-01 PPARG,HSPH1,HSPA1A/HSPA1B,HSPA6,CEBPD,ATF response 6,MAP3K5,DNAJB9,HSPA5,EIF2A,MBTPS2,MBTPS1 ,VCP,ERO1LB 17 Superpathway of 2,6E00 3,33E-01 HADHB,FDFT1,NSDHL,ACAT2,ACAT1,LSS,TM7SF2,H Cholesterol Biosynthesis ADHA,SC5D 18 PPAR Signaling 2,51E00 2,22E-01 -2,236 PPARG,PPARA,MAP3K14,NRAS,TNFRSF1A,SOS2,HR AS,NR1H3,PDGFC,AIP,IKBKB,MAPK3,NCOA1,INSR, NRIP1,RXRA,TNFRSF1B,MAP2K1,PPARGC1A,TNFRS F11B 19 Isoleucine Degradation I 2,49E00 4,29E-01 HADHB,ACAT2,BCAT2,AUH,ACAT1,HADHA

20 Adipogenesis pathway 2,48E00 2,05E-01 PPARG,HDAC9,CCNH,ARNTL,BMP4,LEP,TXNIP,TNF RSF1A,FGF2,CEBPD,PPIP5K1,SENP2,SMAD5,RBP1,S IN3A,FGF1,CTBP1,EBF1,LPIN1,PAXIP1,KDM1A,ERC C3,SIRT1,LPL,KLF3 21 IL-8 Signaling 2,42E00 1,86E-01 1,768 ANGPT2,NAPEPLD,GNB2L1,HRAS,CCND1,PDGFC,G NG7,EIF4EBP1,IRAK1,VEGFA,HMOX1,IKBKB,RHOG, RHOB,RHOT1,MAPK3,GPLD1,RHOU,ITGAV,CYBB,M AP2K1,VASP,ITGB5,LASP1,ATM,NOX4,NRAS,GNA1 2,GNG2,GNAI1,IRAK3,PLD1,RHOQ,IRAK2

22 Tryptophan Degradation 2,39E00 3,68E-01 HADHB,ACAT2,ACAT1,HADHA,HADH,GCDH,HSD17 III (Eukaryotic) B8

23 Oxidative Ethanol 2,32E00 4E-01 ACSS3,ALDH1A3,ACSS2,ACSS1,ACSL1,ALDH7A1 Degradation III 24 Branched-chain α-keto 2,24E00 7,5E-01 BCKDHA,DBT,BCKDHB acid Dehydrogenase Complex

25 Methylmalonyl Pathway 2,24E00 7,5E-01 PCCA,PCCB,MUT

26 NAD Biosynthesis III 2,24E00 7,5E-01 NMNAT2,NMNAT3,NAMPT 27 CDP-diacylglycerol 2,16E00 3,75E-01 AGPAT5,ABHD5,LCLAT1,LPCAT4,AGPAT9,AGPAT3 Biosynthesis I 28 Glucocorticoid Receptor 2,08E00 1,68E-01 YWHAH,SOS2,HSPA1A/HSPA1B,HSPA6,HRAS,TAF7, Signaling CD163,HSPA5,GTF2A1,NR3C1,PTGES3,SMARCA4,P GR,IKBKB,POLR2C,CCL13,CCL2,PCK2,PPP3R1,ANXA 1,MAPK3,MAP2K1,ATM,ADRB2,CREBZF,MAP3K14, TAF9,CCNH,NRAS,CDKN1C,MAP3K1,CHP1,STAT3,P CK1,TSG101,TAF9B,POU2F1,TAF1,GTF2E1,ERCC3,N COA1,NR3C2,NRIP1

29 Noradrenaline and 2,05E00 2,81E-01 ADH1A,ALDH1A3,COMT,ADH1C,ADH1B,PECR,ADH Adrenaline Degradation FE1,LRTOMT,ALDH7A1

30 GM-CSF Signaling 2,04E00 2,3E-01 1,941 NRAS,SOS2,GNB2L1,HRAS,STAT3,CCND1,CSF2RB,C AMK2D,PPP3R1,MAPK3,CISH,HCK,MAP2K1,ATM

31 Ethanol Degradation IV 2,01E00 3,53E-01 ACSS3,ALDH1A3,ACSS2,ACSS1,ACSL1,ALDH7A1

32 tRNA Charging 2,01E00 2,63E-01 WARS2,TARS2,TARSL2,GARS,KARS,DARS,HARS,SAR S,MARS,QARS 33 B Cell Receptor Signaling 2E00 1,8E-01 BLNK,RAP2A,SOS2,HRAS,MAP3K5,FCGR2B,PTEN,IK BKB,CAMK2D,CFL2,CARD10,PPP3R1,MAPK3,GSK3 B,MAP2K1,ATM,MAP3K14,PTPN6,NRAS,MAP3K1,C REB3,ATF2,SYNJ2,CALM1 (includes others),EBF1,DAPP1,PAG1,PLCG2,VAV1,MAP3K3

34 Cholesterol Biosynthesis 1,91E00 3,85E-01 FDFT1,NSDHL,LSS,TM7SF2,SC5D I 35 Cholesterol Biosynthesis 1,91E00 3,85E-01 FDFT1,NSDHL,LSS,TM7SF2,SC5D II (via 24,25- dihydrolanosterol)

36 Cholesterol Biosynthesis 1,91E00 3,85E-01 FDFT1,NSDHL,LSS,TM7SF2,SC5D III (via Desmosterol)

37 Phospholipase C 1,9E00 1,69E-01 1,890 BLNK,NAPEPLD,RALA,GNB2L1,SOS2,RPS6KA3,HRA Signaling S,FCGR2B,GNG7,HMOX1,RHOG,RHOB,AHNAK,RHO T1,PPP3R1,MAPK3,GPLD1,RHOU,MAP2K1,MYL12 A,HDAC9,NRAS,GNG2,PLA2G4C,CHP1,CREB3,PPP1 R14A,ITPR1,PLD1,ATF2,PLA2G4A,CALM1 (includes others),RHOQ,PLCG2,ARHGEF18,ADCY7,LCP2

38 NAD Salvage Pathway III 1,88E00 6E-01 NMRK1,NMNAT2,NMNAT3

39 Lysine Degradation V 1,88E00 6E-01 AASDH,AASDHPPT,ALDH7A1 40 2-oxobutanoate 1,88E00 6E-01 PCCA,PCCB,MUT Degradation I 41 Phosphatidylglycerol 1,88E00 3,33E-01 AGPAT5,ABHD5,LCLAT1,LPCAT4,AGPAT9,AGPAT3 Biosynthesis II (Non- plastidic) 42 β-alanine Degradation I 1,87E00 1E00 ABAT,ALDH6A1

43 L-DOPA Degradation 1,87E00 1E00 COMT,LRTOMT 44 PI3K Signaling in B 1,85E00 1,87E-01 CD81,BLNK,IL4R,NRAS,CHP1,HRAS,ATF6,ITPR1,FCG Lymphocytes R2B,ATF2,PTEN,CALM1 (includes others),IKBKB,CAMK2D,DAPP1,CARD10,PLCG2,IRS 1,MAPK3,PPP3R1,VAV1,IRS2,MAP2K1 45 RAR Activation 1,79E00 1,73E-01 AKR1C3,RDH10,ADH1C,SMAD5,MAP3K5,RBP1,SM ARCA4,PTEN,VEGFA,TNIP1,TRIM24,ALDH1A3,CSN K2A1,SORBS3,MAP2K1,DHRS3,CCNH,IL3RA,MAP3K 1,SNW1,CSF2RB,CSNK2A2,RBP7,ERCC3,IGFBP3,NC OA1,NRIP1,RXRA,ADCY7,PPARGC1A

46 Regulation of Cellular 1,71E00 2,22E-01 1,414 NRAS,CAPNS1,EZR,MAPK3,HRAS,VCL,CAST,CAPN7, Mechanics by Calpain CDKN1B,CCND1,CNGA1,ACTN1 Protease 47 Glioma Signaling 1,65E00 1,91E-01 1,069 CAMK1,NRAS,TFDP1,SOS2,HRAS,CDKN2C,PDGFC,C CND1,CDKN2B,SIN3A,PTEN,CALM1 (includes others),CAMK2D,IGF1,MAPK3,PLCG2,MAP2K1,AT M

48 Superpathway of 1,65E00 2,58E-01 PCCA,MGMT,PCCB,MAT2B,CTH,MUT,BHMT2,SUO Methionine Degradation X

49 Dopamine Degradation 1,65E00 3E-01 ALDH1A3,COMT,SULT1A1,LRTOMT,ALDH7A1,SULT 1A2 50 Telomere Extension by 1,63E00 3,33E-01 HNRNPA1,TERF1,POT1,RAD50,NBN Telomerase 51 SAPK/JNK Signaling 1,62E00 1,93E-01 1,698 NRAS,GNA12,GNG2,SOS2,MAP3K1,HRAS,CRK,MAP 3K5,GNG7,ATF2,DAXX,TRADD,DUSP10,IRS1,DUSP4 ,MAP3K3,ATM 52 NAD Biosynthesis from 2-1,62E00 5E-01 NADSYN1,NMNAT2,NMNAT3 amino-3- carboxymuconate Semialdehyde 53 Thioredoxin Pathway 1,62E00 5E-01 TXN,TXNRD1,TXNRD3 54 Acetyl-CoA Biosynthesis 1,62E00 5E-01 DLAT,DBT,PDHB I (Pyruvate Dehydrogenase Complex)

55 Production of Nitric 1,6E00 1,68E-01 1,671 PPARA,APOE,APOB,PPP1R3C,ARG2,MAP3K5,IKBKB Oxide and Reactive ,RHOG,RHOB,RHOT1,MAPK3,RHOU,CYBB,TNFRSF1 B,MAP2K1,ATM,TNFRSF11B,MAP3K14,PTPN6,TNF Oxygen Species in RSF1A,MAP3K1,IFNGR2,PPP1R14A,NCF4,IRF1,RHO Macrophages Q,PLCG2,IRF8,MAP3K3,CLU

56 Actin Nucleation by ARP- 1,6E00 2,14E-01 1,155 RHOG,NRAS,RHOQ,RHOB,ARPC5L,RHOT1,ARPC2,G WASP Complex NA12,SOS2,RHOU,HRAS,VASP 57 Integrin Signaling 1,58E00 1,65E-01 2,694 RAP2A,RALA,SOS2,HRAS,CRK,PTEN,RHOG,RHOB,R HOT1,MAPK3,ARF4,ITGAV,CAV1,RHOU,GSK3B,VCL ,MAP2K1,VASP,ITGB5,ACTN1,MYL12A,ATM,NRAS, ARPC5L,ITGAL,ARHGAP5,RHOQ,CAPNS1,ARPC2,PL CG2,CAPN7,CTTN 58 Role of JAK2 in Hormone-1,57E00 2,5E-01 PTPN6,GHR,IRS1,SH2B3,SOCS2,IRS2,STAT3,SOCS5 like Cytokine Signaling

59 IGF-1 Signaling 1,57E00 1,88E-01 0,577 YWHAG,NRAS,YWHAH,YWHAB,SOCS2,SOS2,HRAS, STAT3,CSNK2A2,IGF1,MAPK3,IRS1,IGFBP3,CSNK2A 1,IRS2,SOCS5,MAP2K1,ATM 60 Cell Cycle: G1/S 1,56E00 2,06E-01 -0,632 RPL11,HDAC9,MAX,TFDP1,CDKN2C,ATR,GSK3B,CD Checkpoint Regulation KN1B,SKP1,CDKN2B,CCND1,SIN3A,ATM

61 Gαq Signaling 1,55E00 1,72E-01 0,408 NAPEPLD,CHP1,GNG2,GNB2L1,ITPR1,GNA14,PLD1 ,GNG7,CALM1 (includes others),IKBKB,HMOX1,RHOQ,RHOG,RHOB,GNA15, RHOT1,PLCG2,MAPK3,PPP3R1,GPLD1,RHOU,GSK3 B,MAP2K1,AGTR1,ATM 62 PTEN Signaling 1,55E00 1,79E-01 -0,229 FOXO4,NRAS,YWHAH,SHARPIN,SOS2,HRAS,CCND1 ,PTEN,SYNJ2,CSNK2A2,IKBKB,MAGI1,GHR,MAPK3, CSNK2A1,INSR,CDKN1B,GSK3B,MCRS1,MAGI2,MA P2K1 63 Cardiac Hypertrophy 1,52E00 1,61E-01 1,219 GNB2L1,HRAS,ATF6,MAP3K5,GNA14,EIF2B2,GNG7 Signaling ,RHOG,ADRB1,IGF1,RHOB,GNA15,RHOT1,PPP3R1, MAPK3,RHOU,GSK3B,MAP2K1,MYL12A,ADRB2,AT M,MAP3K14,NRAS,GNA12,GNG2,MAP3K1,CHP1,G NAI1,ATF2,CALM1 (includes others),RHOQ,IRS1,PLCG2,ADCY7,MAP3K3

64 PDGF Signaling 1,52E00 1,95E-01 1,291 NRAS,SOS2,MAP3K1,HRAS,CRK,STAT3,PDGFC,SYNJ 2,CSNK2A2,PLCG2,MAPK3,CAV1,CSNK2A1,MAP2K 1,ATM 65 EIF2 Signaling 1,47E00 1,66E-01 -1,213 RPL11,RPL22,SOS2,HRAS,EIF2B2,EIF2A,RPS11,RPL 14,EIF1,RPS20,MAPK3,GSK3B,MAP2K1,ATM,RPL4, NRAS,EIF3H,RPL30,RPL23,EIF3E,EIF3M,RPL15,RPS 6,AGO3,INSR,EIF3L,EIF3K,RPS14

66 Tyrosine Biosynthesis IV 1,43E00 6,67E-01 PCBD2,PCBD1 67 4-aminobutyrate 1,43E00 6,67E-01 SUCLG2,ABAT Degradation I 68 Fatty Acid β-oxidation III 1,43E00 6,67E-01 ECI2,ECI1 (Unsaturated, Odd Number)

69 Phosphatidylcholine 1,42E00 4,29E-01 CEPT1,CHKA,CHPT1 Biosynthesis I 70 Granzyme A Signaling 1,4E00 2,94E-01 PRF1,H1FX,HMGB2,H1F0,APEX1 71 Ephrin B Signaling 1,4E00 1,92E-01 1,633 RGS3,CXCR4,GNA12,GNB2L1,GNG2,GNAI1,HRAS,G NA14,GNG7,GNA15,CFL2,MAPK3,CAP1,VAV1

72 Antiproliferative Role of 1,38E00 2E-01 1,897 PTPN6,NRAS,SSTR2,NPR1,MAPK3,GNB2L1,GNG2,H Somatostatin Receptor 2 RAS,CDKN1B,MAP2K1,GNG7,ATM

73 Role of JAK1 and JAK3 in 1,38E00 2E-01 BLNK,STAT6,IL4R,IL15RA,NRAS,IRS1,MAPK3,IL15,H γc Cytokine Signaling RAS,IRS2,STAT3,ATM

74 Cleavage and 1,38E00 3,33E-01 PAPOLA,CSTF1,NUDT21,WDR33 Polyadenylation of Pre- mRNA 75 Mevalonate Pathway I 1,38E00 3,33E-01 HADHB,ACAT2,ACAT1,HADHA

76 Role of NFAT in 1,37E00 1,65E-01 1,789 BLNK,CSNK1G1,SOS2,GNB2L1,HRAS,GNA14,FCGR2 Regulation of the B,GNG7,IKBKB,HLA- DRB1,GNA15,MAPK3,PPP3R1,GSK3B,MAP2K1,AT Immune Response M,NRAS,GNA12,GNG2,CHP1,GNAI1,ITPR1,ATF2,CA LM1 (includes others),PLCG2,LCP2 77 Retinoate Biosynthesis I 1,28E00 2,33E-01 DHRS3,RBP7,AKR1C3,RDH10,ALDH1A3,ADH1C,RB P1 78 Retinol Biosynthesis 1,28E00 2,33E-01 DHRS3,RBP7,RDH10,LPL,PNPLA3,RBP1,ESD 79 Clathrin-mediated 1,26E00 1,58E-01 APOE,APOB,FGF2,AP1B1,AP2A2,PDGFC,VEGFA,CD Endocytosis Signaling 2AP,ARRB1,SNX9,IGF1,PPP3R1,CSNK2A1,DAB2,ITG B5,ATM,ARPC5L,CHP1,RAB7A,HIP1,TSG101,AP2S1, FGF1,DNM1,CSNK2A2,TF,ARPC2,CTTN,CLU

80 ErbB2-ErbB3 Signaling 1,26E00 1,96E-01 2,530 NRAS,MAPK3,SOS2,HRAS,STAT3,CDKN1B,GSK3B,C CND1,MAP2K1,PTEN,ATM 81 iNOS Signaling 1,25E00 2,09E-01 0,707 IKBKB,CALM1 (includes others),MYD88,IFNGR2,CD14,IRAK3,IRF1,IRAK1,IR AK2 82 Phosphatidylethanolami 1,25E00 3,75E-01 CEPT1,PIGF,CHKA ne Biosynthesis II 83 Citrulline Biosynthesis 1,25E00 3,75E-01 GLS,OAT,ARG2

84 Role of MAPK Signaling 1,24E00 1,9E-01 PLA2G4A,NRAS,CCL2,MAPK3,PLA2G4C,HRAS,PNPL in the Pathogenesis of A3,MAP3K5,MAP2K1,PRDX6,RABGEF1,ATF2 Influenza

85 IL-4 Signaling 1,23E00 1,86E-01 SYNJ2,STAT6,PTPN6,IL4R,HLA- DRB1,NRAS,IL13RA1,IRS1,SOS2,HRAS,NR3C2,NR3C 1,ATM 86 Protein Kinase A 1,23E00 1,44E-01 MYH10,YWHAH,PDE3A,PDE12,GNB2L1,AKAP9,PTE Signaling N,DUSP3,CAMK2D,PPP3R1,MAPK3,GSK3B,APEX1, PTPN6,PTPRG,YWHAG,YWHAB,CREB3,GNG2,PPP1 R14A,PTPN18,PTPN3,ITPR1,PTP4A1,CNGA1,ATF2, H3F3A/H3F3B,PLCG2,DUSP4,H1F0,PTPRA,PTPN13, PPP1R3C,CDC23,GNG7,AKAP11,PTPN4,GLI3,PTPRJ, FLNA,H1FX,DUSP10,MAP2K1,VASP,MYL12A,PTPRK ,CHP1,MAP3K1,GNAI1,TCF7L1,CALM1 (includes others),ADCY7,AKAP1

87 p53 Signaling 1,23E00 1,73E-01 -0,832 HDAC9,PLAGL1,RRM2B,C12orf5,PERP,ST13,CCND1 ,PTEN,CCNG1,SCO2,ADCK3,SIRT1,ATR,GSK3B,TNFR SF10A,ATM,DRAM1 88 MIF-mediated 1,21E00 2,26E-01 2,646 PLA2G4A,MIF,MAPK3,PLA2G4C,CD14,CD74,NR3C1 Glucocorticoid Regulation 89 Glioma Invasiveness 1,21E00 1,93E-01 1,508 RHOG,NRAS,RHOQ,RHOB,RHOT1,MAPK3,ITGAV,R Signaling HOU,HRAS,ITGB5,ATM 90 FLT3 Signaling in 1,19E00 1,83E-01 STAT6,NRAS,SOS2,CREB3,RPS6KA3,HRAS,STAT3,EI Hematopoietic F4EBP1,ATF2,MAPK3,STAT2,MAP2K1,ATM Progenitor Cells 91 FGF Signaling 1,19E00 1,76E-01 0,775 PTPN6,FGF2,SOS2,MAP3K1,CREB3,HRAS,CRK,STAT 3,MAP3K5,ITPR1,ATF2,FGF1,MAPK3,MAP2K1,ATM

92 Huntington's Disease 1,18E00 1,51E-01 SDHB,SOS2,GNB2L1,HSPA1A/HSPA1B,HSPA6,HRAS Signaling ,GNA14,HSPA5,AP2A2,GNG7,NSF,POLR2C,GNA15,I GF1,MAPK3,NAPB,ATM,HDAC9,YKT6,RCOR3,GLS,G NG2,CREB3,ITPR1,HIP1,PSME3,SIN3A,TAF9B,ATF2, DNM1,CAPNS1,ATP5B,HTT,CAPN7

93 fMLP Signaling in 1,17E00 1,68E-01 1,500 FPR3,NOX4,NRAS,ARPC5L,CHP1,GNB2L1,GNG2,GN Neutrophils AI1,HRAS,ITPR1,GNG7,CALM1 (includes others),MAPK3,ARPC2,PPP3R1,CYBB,MAP2K1,AT M

94 PKCθ Signaling in T 1,17E00 1,68E-01 MAP3K14,NRAS,CHP1,SOS2,MAP3K1,HRAS,MAP3 Lymphocytes K5,IKBKB,HLA- DRB1,CAMK2D,POU2F1,MAPK3,PLCG2,PPP3R1,VA V1,MAP3K3,LCP2,ATM 95 Eicosanoid Signaling 1,16E00 1,9E-01 0,447 PLA2G4A,LTA4H,PTGES,AKR1C3,PLA2G4C,ALOX5A P,PNPLA3,ALOX5,TBXAS1,PTGER4,PRDX6

96 Retinoate Biosynthesis II 1,16E00 5E-01 RBP7,RBP1

97 Eumelanin Biosynthesis 1,16E00 5E-01 MIF,DDT

98 Arginine Degradation I 1,16E00 5E-01 OAT,ARG2 (Arginase Pathway) 99 Phenylalanine 1,16E00 5E-01 PCBD2,PCBD1 Degradation I (Aerobic)

100 Non-Small Cell Lung 1,16E00 1,85E-01 1,667 NRAS,TFDP1,MAPK3,SOS2,HRAS,ITPR1,RXRA,CCN Cancer Signaling D1,MAP2K1,SIN3A,RASSF1,ATM 101 JAK/Stat Signaling 1,15E00 1,81E-01 1,941 STAT6,PTPN6,NRAS,MAPK3,CISH,SOCS2,SOS2,HRA S,STAT2,STAT3,SOCS5,MAP2K1,ATM 102 mTOR Signaling 1,15E00 1,55E-01 0,471 NAPEPLD,RPS6KA3,HRAS,PDGFC,RPS11,EIF4EBP1, VEGFA,HMOX1,RHOG,RPS20,RHOB,RHOT1,MAPK3 ,GPLD1,RHOU,ATM,NRAS,EIF3H,EIF3E,PLD1,EIF3M ,RPS6,RHOQ,IRS1,INSR,EIF3L,RPS14,EIF3K

103 Nur77 Signaling in T 1,15E00 2E-01 CALM1 (includes others),HDAC9,HLA- Lymphocytes DRB1,PPP3R1,CHP1,RXRA,MAP3K3,MAP2K5,SIN3A 104 Induction of Apoptosis 1,12E00 1,86E-01 1,508 IKBKB,MAP3K14,TRADD,DAXX,SLC25A6,CXCR4,TN by HIV1 FRSF1A,MAP3K5,SLC25A10,TNFRSF1B,TNFRSF11B 105 Thyroid Cancer Signaling 1,12E00 2,05E-01 PPARG,NRAS,MAPK3,HRAS,TCF7L1,RXRA,CCND1, MAP2K1 106 NRF2-mediated 1,12E00 1,54E-01 2,828 MAF,HSPB8,HRAS,MAP3K5,DNAJA1,MAFG,HMOX Oxidative Stress 1,MAPK3,ABCC1,VCP,UBE2K,GCLM,TXN,GSK3B,M AP2K1,ATM,NRAS,MAP3K1,NQO1,DNAJB9,TXNRD Response 1,MGST2,SQSTM1,DNAJB6,ENC1,MAP2K5,FTH1

107 Prostate Cancer 1,11E00 1,75E-01 NRAS,TFDP1,SOS2,CREB3,HRAS,CCND1,SIN3A,ATF Signaling 2,PTEN,MAPK3,CDKN1B,GSK3B,MAP2K1,ATM 108 Prolactin Signaling 1,11E00 1,78E-01 1,732 NRAS,MAPK3,PLCG2,IRS1,SOCS2,SOS2,HRAS,STAT 3,SOCS5,MAP2K1,NR3C1,IRF1,ATM 109 Prostanoid Biosynthesis 1,11E00 3,33E-01 PTGES,TBXAS1,PTGES3

110 Acute Myeloid Leukemia 1,08E00 1,76E-01 0,577 NRAS,SOS2,HRAS,TCF7L1,STAT3,CCND1,CSF1R,EIF Signaling 4EBP1,CSF2RB,MAPK3,MAP2K1,MAP2K5,ATM 111 The Visual Cycle 1,06E00 2,67E-01 DHRS3,RBP7,RDH10,RBP1 112 Endoplasmic Reticulum 1,05E00 2,38E-01 MBTPS1,ATF6,MAP3K5,HSPA5,MBTPS2 Stress Pathway

113 Serotonin Degradation 1,05E00 1,91E-01 ADH1A,ALDH1A3,SULT1A1,ADH1C,ADH1B,PECR,A DHFE1,ALDH7A1,SULT1A2 114 Chemokine Signaling 1,04E00 1,76E-01 1,732 CALM1 (includes others),NRAS,CCL13,CAMK1,CAMK2D,CCL2,CXCR4, PLCG2,MAPK3,GNAI1,HRAS,MAP2K1 115 ERK5 Signaling 1,04E00 1,8E-01 1,414 YWHAG,NRAS,YWHAH,YWHAB,GNA12,CREB3,RPS 6KA3,HRAS,MAP3K3,MAP2K5,ATF2 116 NF-κB Signaling 1,02E00 1,52E-01 1,800 MAP3K14,AZI2,NRAS,BMP4,TNFRSF1A,MYD88,MA P3K1,TNFAIP3,HRAS,IRAK3,IRAK1,CSNK2A2,IKBKB, TRADD,TNIP1,GHR,CARD10,PLCG2,CSNK2A1,INSR, GSK3B,TNFRSF1B,MAP3K3,TNFRSF11B,ATM

117 Type II Diabetes Mellitus 1,01E00 1,61E-01 PPARG,MAP3K14,SLC27A2,TNFRSF1A,SOCS2,MAP Signaling 3K1,MAP3K5,TRADD,IKBKB,MAPK3,IRS1,IRS2,INSR ,TNFRSF1B,SOCS5,ACSL1,ATM,TNFRSF11B

118 Ephrin Receptor 1,01E00 1,51E-01 RGS3,PTPN13,SOS2,GNB2L1,HRAS,CRK,GNA14,PD Signaling GFC,GNG7,VEGFA,CFL2,GNA15,MAPK3,MAP2K1,M AP3K14,NRAS,CXCR4,ARPC5L,GNA12,GNG2,CREB3 ,GNAI1,STAT3,ATF2,FGF1,ARPC2

119 Growth Hormone 1E00 1,74E-01 0,302 PTPN6,GHR,IGF1,IRS1,PLCG2,MAPK3,SOCS2,IGFBP Signaling 3,RPS6KA3,STAT3,SOCS5,ATM 120 Methylglyoxal 9,96E-01 3E-01 AKR1C1/AKR1C2,FAM213B,AKR1C3 Degradation III 121 IL-1 Signaling 9,86E-01 1,65E-01 1,155 MAP3K14,MYD88,GNA12,GNB2L1,MAP3K1,GNG2, GNAI1,GNA14,IRAK3,GNG7,IRAK1,IKBKB,GNA15,A DCY7,IRAK2 122 Antioxidant Action of 9,86E-01 1,65E-01 -1,732 NAPEPLD,PLA2G4C,PRDX6,PLD1,TXNRD1,TXNRD3, Vitamin C CSF2RB,HMOX1,IKBKB,PLA2G4A,PLCG2,MAPK3,GP LD1,PNPLA3,TXN 123 Nucleotide Excision 9,8E-01 2E-01 RPA4,CCNH,RPA3,POLR2C,ERCC3,ERCC8,XPA Repair Pathway 124 Pancreatic 9,76E-01 1,6E-01 1,387 NAPEPLD,RALA,TFDP1,STAT3,PDGFC,CCND1,RALB Adenocarcinoma P1,CDKN2B,SIN3A,PLD1,VEGFA,HMOX1,MAPK3,G PLD1,CDKN1B,MAP2K1,ATM Signaling 125 NGF Signaling 9,76E-01 1,6E-01 2,668 MAP3K14,NRAS,CREB3,SOS2,MAP3K1,RPS6KA3,H RAS,CRK,MAP3K5,ATF2,IKBKB,RHOG,MAPK3,PLCG 2,MAP3K3,MAP2K1,ATM 126 Acute Phase Response 9,75E-01 1,51E-01 2,982 SOCS2,SOS2,HRAS,MAP3K5,NR3C1,RBP1,IRAK1,TR Signaling ADD,HMOX1,IKBKB,MAPK3,OSMR,TNFRSF1B,MAP 2K1,TNFRSF11B,MAP3K14,NRAS,MYD88,TNFRSF1 A,MAP3K1,STAT3,C5,RBP7,TF,SOCS5

127 RAN Signaling 9,73E-01 2,5E-01 KPNA3,KPNA2,KPNA1,IPO5 128 Superpathway of 9,73E-01 2,5E-01 HADHB,ACAT2,ACAT1,HADHA Geranylgeranyldiphosph ate Biosynthesis I (via Mevalonate) 129 Ceramide Biosynthesis 9,73E-01 4E-01 SPTLC1,SPTLC3

130 Tetrapyrrole 9,73E-01 4E-01 ALAS1,HMBS Biosynthesis II 131 Glutamate Degradation 9,73E-01 4E-01 SUCLG2,ABAT III (via 4-aminobutyrate)

132 Folate 9,73E-01 4E-01 SHMT1,MTHFD1 Polyglutamylation 133 CXCR4 Signaling 9,72E-01 1,52E-01 0,943 NRAS,CXCR4,GNA12,GNG2,GNB2L1,GNAI1,HRAS,C RK,ITPR1,GNA14,GNG7,RHOG,RHOQ,RHOB,GNA15 ,RHOT1,MAPK3,RHOU,ELMO2,MAP2K1,ADCY7,AT M,MYL12A 134 Hypoxia Signaling in the 9,61E-01 1,75E-01 UBE2G2,VEGFA,UBE2L3,UBE2Q1,NQO1,CREB3,UB Cardiovascular System E2V2,UBE2F,PTEN,ATM,ATF2

135 EGF Signaling 9,59E-01 1,79E-01 0,632 CSNK2A2,MAPK3,SOS2,MAP3K1,CSNK2A1,HRAS,S TAT3,ITPR1,MAP2K1,ATM 136 Fcγ Receptor-mediated 9,56E-01 1,63E-01 2,840 NAPEPLD,ARPC5L,CRK,PLD1,PTEN,MYO5A,HMOX1 Phagocytosis in ,MAPK3,ARPC2,EZR,GPLD1,HCK,VAV1,VASP,LCP2 Macrophages and Monocytes

137 Type I Diabetes Mellitus 9,37E-01 1,6E-01 MAP3K14,TNFRSF1A,HLA- Signaling A,MYD88,SOCS2,IFNGR2,MAP3K5,IRF1,IRAK1,IKBK B,TRADD,PRF1,HLA- DRB1,TNFRSF1B,SOCS5,TNFRSF11B 138 Thio-molybdenum 9,34E-01 1E00 MOCOS Cofactor Biosynthesis 139 Acyl Carrier Protein 9,34E-01 1E00 AASDHPPT Metabolism 140 Glutamine Biosynthesis I 9,34E-01 1E00 GLUL

141 Methylglyoxal 9,34E-01 1E00 LDHD Degradation VI 142 L-cysteine Degradation II 9,34E-01 1E00 CTH

143 Lanosterol Biosynthesis 9,34E-01 1E00 LSS

144 Sulfite Oxidation IV 9,34E-01 1E00 SUOX 145 IL-3 Signaling 9,3E-01 1,69E-01 CSF2RB,STAT6,PTPN6,NRAS,IL3RA,MAPK3,PPP3R1 ,CHP1,HRAS,STAT3,MAP2K1,ATM 146 Role of BRCA1 in DNA 9,24E-01 1,72E-01 -0,816 FANCE,FAM175A,POU2F1,MSH6,RFC1,ATR,RFC5,R Damage Response AD50,SMARCA4,ATM,NBN 147 Assembly of RNA 9,18E-01 1,8E-01 TAF9,CCNH,TAF1,POLR2C,GTF2E1,ERCC3,TAF7,GTF Polymerase II Complex 2A1,TAF9B

148 γ-linolenate Biosynthesis 8,97E-01 2,35E-01 SLC27A2,CYB5A,ACSL1,FADS1 II (Animals)

149 Phospholipases 8,79E-01 1,76E-01 HMOX1,PLA2G4A,NAPEPLD,PLCG2,GPLD1,PLA2G4 C,PNPLA3,PLD1,PRDX6 150 Regulation of eIF4 and 8,75E-01 1,5E-01 0,707 NRAS,EIF3H,SOS2,HRAS,EIF3E,EIF2B2,EIF2A,RPS11 p70S6K Signaling ,EIF3M,EIF4EBP1,RPS6,EIF1,RPS20,IRS1,MAPK3,AG O3,MAP2K1,EIF3L,EIF3K,RPS14,ATM

151 4-1BB Signaling in T 8,41E-01 1,94E-01 0,816 IKBKB,MAP3K14,MAPK3,MAP3K5,MAP2K1,ATF2 Lymphocytes 152 Endometrial Cancer 8,4E-01 1,73E-01 NRAS,MAPK3,SOS2,HRAS,GSK3B,CCND1,MAP2K1, Signaling PTEN,ATM 153 PPARα/RXRα Activation 8,33E-01 1,45E-01 -0,447 PPARA,MAP3K14,NRAS,SOS2,ACVR1,HRAS,GNA14, AP2A2,AIP,CAND1,IKBKB,GHR,GNA15,PLCG2,IRS1, MAPK3,LPL,INSR,RXRA,MAP2K1,ADCY7,ACVR1C,IT GB5,PPARGC1A 154 Arginine Degradation VI 8,31E-01 3,33E-01 OAT,ARG2 (Arginase 2 Pathway)

155 Zymosterol Biosynthesis 8,31E-01 3,33E-01 NSDHL,TM7SF2

156 VEGF Signaling 8,28E-01 1,57E-01 0,577 VEGFA,PTPN6,EIF1,NRAS,MAPK3,PLCG2,SOS2,HRA S,VCL,MAP2K1,EIF2B2,PDGFC,ACTN1,ATM

157 ILK Signaling 8,24E-01 1,44E-01 -0,392 MYH10,MYH9,PDGFC,CCND1,PTEN,VEGFA,RHOG, CFL2,RHOB,RHOT1,FLNA,PPAP2B,MAPK3,RHOU,IR S2,GSK3B,ITGB5,ACTN1,ATM,NACA,TNFRSF1A,FER MT2,CREB3,ATF2,RHOQ,IRS1 158 Insulin Receptor 8,23E-01 1,5E-01 FOXO4,NRAS,PPP1R3C,SOS2,HRAS,PPP1R14A,CRK, Signaling EIF2B2,PTEN,EIF4EBP1,SYNJ2,RHOQ,IRS1,MAPK3,I RS2,INSR,GSK3B,MAP2K1,ATM 159 Neurotrophin/TRK 8,22E-01 1,64E-01 0,905 NRAS,SPRY2,MAPK3,SOS2,CREB3,HRAS,MAP3K5, Signaling MAP2K1,MAP2K5,ATM,ATF2 160 LXR/RXR Activation 8,08E-01 1,5E-01 -2,673 APOE,MLXIPL,APOB,TNFRSF1A,NR1H3,ARG2,CETP, FDFT1,TF,CCL2,LPL,CD14,ACACA,RXRA,TNFRSF1B, HADH,CLU,TNFRSF11B 161 T Helper Cell 7,79E-01 1,64E-01 STAT6,IL4R,HLA- Differentiation DRB1,TNFRSF1A,IL10RB,IL10RA,IFNGR2,STAT3,TNF RSF1B,TNFRSF11B 162 Estrogen-Dependent 7,79E-01 1,64E-01 NRAS,IGF1,MAPK3,CREB3,HSD17B12,HRAS,CCND1 Breast Cancer Signaling ,HSD17B8,ATM,ATF2

163 Death Receptor 7,74E-01 1,54E-01 2,138 MAP3K14,PARP16,TNFRSF1A,PARP3,MAP3K5,PAR Signaling P9,ARHGDIB,IKBKB,TRADD,DAXX,TIPARP,TNFRSF1 B,TNFRSF10A,PARP14 164 Regulation of IL-2 7,74E-01 1,58E-01 IKBKB,CALM1 (includes Expression in Activated others),NRAS,PLCG2,MAPK3,PPP3R1,SOS2,MAP3K 1,CHP1,HRAS,VAV1,MAP2K1 and Anergic T Lymphocytes

165 Lipid Antigen 7,64E-01 2,11E-01 PSAP,AP1B1,AP2A2,AP2S1 Presentation by CD1 166 Melanocyte 7,6E-01 1,55E-01 1,941 PTPN6,NRAS,SOS2,CREB3,RPS6KA3,HRAS,CRK,ATF Development and 2,PLCG2,MAPK3,ADCY7,MAP2K1,ATM Pigmentation Signaling

167 Transcriptional 7,52E-01 1,75E-01 TRIM24,RIF1,HESX1,GATA6,TCF7L1,STAT3,ZFHX3 Regulatory Network in Embryonic Stem Cells

168 Chronic Myeloid 7,49E-01 1,52E-01 HDAC9,NRAS,TFDP1,SOS2,HRAS,CRK,CCND1,SIN3A Leukemia Signaling ,CTBP1,IKBKB,MAPK3,CDKN1B,MAP2K1,ATM 169 Circadian Rhythm 7,48E-01 1,82E-01 PER3,PER1,ARNTL,NR1D1,CREB3,ATF2 Signaling 170 Cyclins and Cell Cycle 7,45E-01 1,56E-01 0,333 HDAC9,CCNH,TFDP1,CDKN2C,ATR,CDKN1B,GSK3B, Regulation SKP1,CCND1,CDKN2B,SIN3A,ATM 171 NAD biosynthesis II 7,31E-01 2,31E-01 NADSYN1,NMNAT2,NMNAT3 (from tryptophan) 172 Superpathway of Serine 7,18E-01 2,86E-01 PHGDH,SHMT1 and Glycine Biosynthesis I 173 Inositol Pyrophosphates 7,18E-01 2,86E-01 IPPK,PPIP5K1 Biosynthesis

174 Role of IL-17F in Allergic 7,13E-01 1,71E-01 IGF1,CCL2,MAPK3,CREB3,RPS6KA3,MAP2K1,ATF2 Inflammatory Airway Diseases 175 Bladder Cancer Signaling 7,08E-01 1,51E-01 NRAS,MMP28,TFDP1,FGF2,HRAS,CCND1,PDGFC,SI N3A,FGF1,VEGFA,MAPK3,MAP2K1,RASSF1

176 IL-9 Signaling 7,05E-01 1,76E-01 0,000 IRS1,CISH,SOCS2,IRS2,STAT3,ATM 177 Oncostatin M Signaling 7,05E-01 1,76E-01 2,449 NRAS,MAPK3,HRAS,OSMR,STAT3,MAP2K1

178 Interferon Signaling 7,05E-01 1,76E-01 1,000 IFNGR2,STAT2,IRF9,IFITM2,IRF1,IFITM1 179 Caveolar-mediated 7,03E-01 1,55E-01 COPZ1,FLNA,HLA- Endocytosis Signaling A,ITGAV,CAV1,COPE,FLOT1,INSR,PTRF,ITGAL,ITGB 5 180 Cell Cycle Control of 7,01E-01 1,85E-01 MCM3,RPA4,MCM6,RPA3,ORC3 Chromosomal Replication 181 RhoGDI Signaling 7,01E-01 1,4E-01 -0,728 ARPC5L,GNA12,GNG2,GNB2L1,GDI2,GNAI1,GNA14 ,ARHGDIB,GNG7,ARHGAP5,RHOQ,RHOG,CFL2,RH OB,GNA15,RHOT1,EZR,ARPC2,RHOU,ARHGEF18,A RHGDIA,DLC1,MSN,MYL12A

182 Remodeling of Epithelial 6,87E-01 1,56E-01 2,000 DNM1,RALA,ARPC5L,ARPC2,MAPRE1,TUBB2A,RAB Adherens Junctions 7A,VCL,ACTN1,TUBB2B

183 Androgen Signaling 6,87E-01 1,45E-01 0,000 CCNH,GNA12,GNB2L1,GNG2,GNAI1,GNA14,GTF2A 1,CCND1,GNG7,CALM1 (includes others),POLR2C,GNA15,MAPK3,GTF2E1,ERCC3,NC OA1 184 p70S6K Signaling 6,82E-01 1,44E-01 0,000 IL4R,YWHAG,NRAS,YWHAH,EEF2,YWHAB,SOS2,GN AI1,HRAS,PLD1,RPS6,MAPK3,PLCG2,IRS1,MAP2K1, AGTR1,ATM 185 Melanoma Signaling 6,76E-01 1,67E-01 NRAS,MAPK3,HRAS,CCND1,MAP2K1,PTEN,ATM

186 DNA Double-Strand 6,63E-01 2,14E-01 RAD50,ATM,NBN Break Repair by Homologous Recombination 187 DNA Double-Strand 6,63E-01 2,14E-01 RAD50,ATM,NBN Break Repair by Non- Homologous End Joining

188 Superpathway of 6,63E-01 2,14E-01 GLS,OAT,ARG2 Citrulline Metabolism

189 Leukotriene 6,63E-01 2,14E-01 LTA4H,MGST2,ALOX5 Biosynthesis 190 γ-glutamyl Cycle 6,63E-01 2,14E-01 OPLAH,GGCT,GCLM 191 Vitamin-C Transport 6,63E-01 2,14E-01 TXN,TXNRD1,TXNRD3 192 Epoxysqualene 6,59E-01 5E-01 FDFT1 Biosynthesis 193 Lipoate Biosynthesis and 6,59E-01 5E-01 LIAS Incorporation II 194 Choline Degradation I 6,59E-01 5E-01 ALDH7A1 195 Alanine Degradation III 6,59E-01 5E-01 GPT2

196 Alanine Biosynthesis II 6,59E-01 5E-01 GPT2

197 L-cysteine Degradation 6,59E-01 5E-01 MPST III 198 Sulfate Activation for 6,59E-01 5E-01 PAPSS1 Sulfonation 199 Thiosulfate 6,59E-01 5E-01 TST Disproportionation III (Rhodanese) 200 Cysteine 6,59E-01 5E-01 CTH Biosynthesis/Homocyste ine Degradation 201 Putrescine Biosynthesis 6,59E-01 5E-01 ODC1 III 202 Formaldehyde Oxidation 6,59E-01 5E-01 ESD II (Glutathione- dependent)

203 Glycine Biosynthesis I 6,59E-01 5E-01 SHMT1 204 Glutamine Degradation I 6,59E-01 5E-01 GLS

205 G Beta Gamma Signaling 6,58E-01 1,48E-01 NRAS,GNA12,SOS2,GNB2L1,GNG2,GNAI1,HRAS,G NA14,GNG7,GNA15,PLCG2,MAPK3,CAV1 206 GNRH Signaling 6,58E-01 1,42E-01 0,943 MAP3K14,NRAS,SOS2,MAP3K1,CREB3,GNAI1,HRA S,GNA14,MAP3K5,ITPR1,ATF2,DNM1,CAMK2D,GN A15,MAPK3,MAP3K3,MAP2K1,ADCY7

207 Amyloid Processing 6,56E-01 1,6E-01 -1,000 CSNK2A2,CAPNS1,MAPK3,CSNK2A1,NCSTN,BACE2, CAPN7,GSK3B 208 TNFR2 Signaling 6,56E-01 1,79E-01 2,000 IKBKB,MAP3K14,MAP3K1,TNFAIP3,TNFRSF1B 209 Polyamine Regulation in 6,53E-01 1,9E-01 PPARG,MAX,PSME3,ODC1 Colon Cancer

210 NAD Salvage Pathway II 6,53E-01 1,9E-01 NMRK1,ACP6,NMNAT2,NMNAT3

211 Pyrimidine 6,53E-01 1,9E-01 AK1,RRM2B,CMPK1,DTYMK Deoxyribonucleotides De Novo Biosynthesis I

212 STAT3 Pathway 6,49E-01 1,51E-01 PTPN6,GHR,NRAS,MAPK3,CISH,SOCS2,HRAS,STAT3 ,INSR,MAP2K1,SOCS5 213 HGF Signaling 6,48E-01 1,44E-01 2,138 MAP3K14,NRAS,SOS2,MAP3K1,HRAS,STAT3,MAP3 K5,CCND1,ATF2,ETS2,PLCG2,MAPK3,MAP3K3,MAP 2K1,ATM 214 p38 MAPK Signaling 6,44E-01 1,43E-01 0,535 TNFRSF1A,PLA2G4C,CREB3,RPS6KA3,MAP3K5,IRA K3,ATF2,IRAK1,DAXX,PLA2G4A,TRADD,H3F3A/H3F 3B,MAX,DUSP10,TNFRSF1B,IRAK2 215 Retinoic acid Mediated 6,42E-01 1,55E-01 0,707 PARP16,TIPARP,DAP3,PARP3,RXRA,TNFRSF10A,PA Apoptosis Signaling RP9,IRF1,PARP14

216 ErbB4 Signaling 6,42E-01 1,55E-01 2,121 ADAM17,NRAS,PLCG2,MAPK3,SOS2,NCSTN,HRAS, MAP2K1,ATM 217 Xenobiotic Metabolism 6,4E-01 1,33E-01 CAMK1,MAF,HS2ST1,HRAS,MAP3K5,PTGES3,SULT Signaling 1A2,HMOX1,ALDH1L1,CAMK2D,ALDH1A3,MAPK3, MAP2K1,ALDH6A1,ALDH7A1,ATM,MAP3K14,NRAS ,MGMT,NQO1,MAP3K1,AIP,ESD,MGST2,ANKRA2,S ULT1A1,NCOA1,NRIP1,RXRA,ALDH16A1,MAP3K3, MAP2K5,PPARGC1A 218 Ovarian Cancer Signaling 6,39E-01 1,41E-01 GJA1,NRAS,TFDP1,LHCGR,HRAS,TCF7L1,PDGFC,CC ND1,SIN3A,PTEN,VEGFA,ARRB1,MAPK3,MSH6,GSK 3B,MAP2K1,WNT11,ATM 219 Glioblastoma 6,36E-01 1,39E-01 0,688 NRAS,SOS2,HRAS,ITPR1,PDGFC,CCND1,PTEN,RHO Multiforme Signaling G,RHOQ,RHOB,IGF1,RHOT1,MAPK3,PLCG2,RHOU, CDKN1B,GSK3B,MAP2K1,WNT11,ATM

220 Virus Entry via Endocytic 6,35E-01 1,46E-01 DNM1,NRAS,FLNA,HLA- Pathways A,PLCG2,CAV1,HRAS,AP1B1,AP2A2,ITGAL,ITGB5,A P2S1,ATM 221 Granulocyte Adhesion 6,34E-01 1,38E-01 CD99,FPR3,MMP28,CLDN15,TNFRSF1A,CXCR4,GN and Diapedesis AI1,CKLF,ITGAL,C5,SELPLG,GLG1,CLDN23,CCL13,CC L2,EZR,CCL26,CCL18,TNFRSF1B,CCL19,TNFRSF11B, MSN 222 Complement System 6,27E-01 1,67E-01 1,000 C1QC,C1QA,C6,C1QB,C3AR1,C5 223 Salvage Pathways of 6,26E-01 2,5E-01 TK2,APOBEC3G Pyrimidine Deoxyribonucleotides

224 Actin Cytoskeleton 6,2E-01 1,34E-01 MYH10,MYH9,FGF2,SOS2,HRAS,CRK,SSH1,PDGFC,I Signaling QGAP2,CFL2,FLNA,EZR,MAPK3,PFN4,PFN2,VCL,MA P2K1,ACTN1,MYL12A,ATM,NRAS,ARPC5L,GNA12,F GF1,ARPC2,CD14,VAV1,MSN

225 14-3-3-mediated 6,04E-01 1,4E-01 YWHAG,NRAS,YWHAH,YWHAB,TNFRSF1A,TUBB2A Signaling ,HRAS,MAP3K5,TUBB2B,SRPK2,PLCG2,MAPK3,CDK N1B,GSK3B,MAP2K1,ATM 226 Germ Cell-Sertoli Cell 6,01E-01 1,36E-01 MAP3K14,NRAS,TNFRSF1A,TUBB2A,PVRL3,MAP3K Junction Signaling 1,HRAS,MAP3K5,TUBB2B,RHOQ,RHOG,CFL2,RHOB ,RHOT1,PPAP2B,MAPK3,RHOU,MAP3K3,MAP2K1, ACTN1,ATM 227 Semaphorin Signaling in 5,95E-01 1,54E-01 SEMA3A,RHOG,RHOQ,CFL2,RHOB,RHOT1,MAPK3, Neurons RHOU 228 Cholecystokinin/Gastrin- 5,88E-01 1,41E-01 0,000 RHOQ,RHOG,NRAS,RHOB,RHOT1,MAPK3,GNA12,S mediated Signaling OS2,RHOU,HRAS,ITPR1,MAP2K1,MAP2K5,ATF2

229 Thrombin Signaling 5,88E-01 1,34E-01 0,447 CAMK1,GNB2L1,HRAS,GNA14,GNG7,IKBKB,CAMK2 D,RHOG,GNA15,RHOB,RHOT1,MAPK3,RHOU,GATA 6,MAP2K1,ATM,MYL12A,NRAS,GNA12,GNG2,GNAI 1,ITPR1,RHOQ,PLCG2,ADCY7

230 Role of Tissue Factor in 5,86E-01 1,4E-01 NRAS,GNA12,RPS6KA3,HRAS,GNA14,PTEN,VEGFA, Cancer ARRB1,GNA15,CFL2,MAPK3,HCK,ITGAV,ITGB5,AT M 231 IL-10 Signaling 5,8E-01 1,47E-01 HMOX1,IKBKB,MAP3K14,IL4R,IL10RB,IL10RA,CD14 ,ARG2,STAT3,FCGR2B 232 GDNF Family Ligand- 5,8E-01 1,47E-01 1,000 NRAS,IRS1,PLCG2,MAPK3,SOS2,HRAS,IRS2,ITPR1, Receptor Interactions MAP2K1,ATM 233 LPS/IL-1 Mediated 5,76E-01 1,32E-01 3,606 PPARA,APOE,SLC27A2,HS2ST1,ALAS1,IRAK1,SULT1 Inhibition of RXR A2,CETP,ALDH1L1,ALDH1A3,TNFRSF1B,ALDH6A1,T NFRSF11B,ALDH7A1,TNFRSF1A,MYD88,MGMT,MA Function P3K1,NR1H3,MGST2,SULT1A1,NCOA1,CD14,RXRA, ALDH16A1,ACSL1,PPARGC1A

234 Mouse Embryonic Stem 5,69E-01 1,41E-01 1,387 DVL2,ID2,NRAS,BMP4,MAPK3,SOS2,HRAS,GSK3B,S Cell Pluripotency MAD5,STAT3,TCF7L1,MAP2K1,ATM

235 IL-2 Signaling 5,67E-01 1,51E-01 1,633 CSNK2A2,NRAS,MAPK3,SOS2,CSNK2A1,HRAS,MAP 2K1,ATM 236 Renin-Angiotensin 5,66E-01 1,39E-01 1,807 PTPN6,NRAS,SOS2,MAP3K1,HRAS,STAT3,ITPR1,AT Signaling F2,CCL2,PLCG2,MAPK3,MAP2K1,ADCY7,AGTR1,AT M 237 Synaptic Long Term 5,66E-01 1,38E-01 NRAS,PPP1R3C,CREB3,CHP1,PPP1R14A,HRAS,GNA Potentiation 14,ITPR1,ATF2,CALM1 (includes others),CAMK2D,GNA15,MAPK3,PLCG2,PPP3R1,M AP2K1 238 IL-6 Signaling 5,66E-01 1,38E-01 2,840 MAP3K14,NRAS,TNFRSF1A,SOS2,HRAS,STAT3,VEG FA,IKBKB,CSNK2A2,MAPK3,CSNK2A1,CD14,TNFRSF 1B,MAP2K1,ATM,TNFRSF11B 239 cAMP-mediated 5,64E-01 1,31E-01 1,225 CAMK1,PDE12,PDE3A,AKAP9,LHCGR,AKAP11,CAM signaling K2D,ADRB1,MAPK3,PPP3R1,PKIA,MAP2K1,APEX1, PTGER4,ADRB2,NPY1R,CREB3,GNAI1,STAT3,CNGA 1,ATF2,CALM1 (includes others),NPR3,DUSP4,ADCY7,AGTR1,AKAP1,PKIG

240 Neuregulin Signaling 5,5E-01 1,41E-01 1,897 RPS6,ADAM17,NRAS,PLCG2,MAPK3,SOS2,HRAS,CR K,ERRFI1,CDKN1B,MAP2K1,PTEN 241 α-Adrenergic Signaling 5,5E-01 1,41E-01 1,667 CALM1 (includes others),NRAS,PLCG2,MAPK3,GNB2L1,GNG2,GNAI1 ,HRAS,ITPR1,ADCY7,MAP2K1,GNG7 242 Epithelial Adherens 5,5E-01 1,35E-01 MYH10,MYH9,NRAS,ARPC5L,TUBB2A,PVRL3,ACVR Junction Signaling 1,HRAS,CRK,TCF7L1,FGF1,TUBB2B,PTEN,MAGI1,A RPC2,VCL,MAGI2,ACVR1C,ACTN1 243 Assembly of RNA 5,5E-01 2,22E-01 POLR1D,POLR1A Polymerase I Complex

244 Heme Biosynthesis II 5,5E-01 2,22E-01 ALAS1,HMBS 245 Folate Transformations I 5,5E-01 2,22E-01 SHMT1,MTHFD1

246 Aryl Hydrocarbon 5,49E-01 1,35E-01 1,508 TFDP1,NQO1,CCND1,SMARCA4,PTGES3,AIP,ALDH1 Receptor Signaling L1,MGST2,ALDH1A3,MAPK3,ATR,NRIP1,CDKN1B,R XRA,ALDH16A1,ALDH6A1,ATM,ALDH7A1

247 Mismatch Repair in 5,48E-01 1,88E-01 MSH6,RFC1,RFC5 Eukaryotes 248 Glutathione Redox 5,48E-01 1,88E-01 GSTZ1,MGST2,PRDX6 Reactions I 249 G Protein Signaling 5,38E-01 1,61E-01 PLCG2,GNB2L1,GNG2,INSR,GNG7 Mediated by Tubby 250 Tec Kinase Signaling 5,35E-01 1,33E-01 1,941 STAT6,GNA12,GNG2,GNB2L1,GNAI1,STAT3,GNA14 ,GNG7,RHOQ,RHOG,GNA15,RHOB,RHOT1,PLCG2, HCK,RHOU,VAV1,STAT2,TNFRSF10A,ATM

251 HMGB1 Signaling 5,3E-01 1,36E-01 1,500 NRAS,TNFRSF1A,IFNGR2,HRAS,RHOG,RHOQ,RHOB ,CCL2,RHOT1,MAPK3,RHOU,TNFRSF1B,MAP2K1,M AP2K5,ATM,TNFRSF11B 252 FAK Signaling 5,29E-01 1,4E-01 NRAS,CAPNS1,PLCG2,MAPK3,SOS2,HRAS,CRK,VCL, CAPN7,MAP2K1,PTEN,ATM 253 T Cell Receptor Signaling 5,29E-01 1,38E-01 CALM1 (includes others),IKBKB,NRAS,PPP3R1,MAPK3,PAG1,MAP3K 1,SOS2,HRAS,VAV1,MAP2K1,LCP2,ATM 254 ERK/MAPK Signaling 5,28E-01 1,31E-01 3,273 PPARG,NRAS,YWHAG,YWHAH,YWHAB,VRK2,PPP1 R3C,CREB3,SOS2,PLA2G4C,HRAS,PPP1R14A,CRK,S TAT3,EIF4EBP1,ATF2,PLA2G4A,H3F3A/H3F3B,ETS2 ,PLCG2,MAPK3,DUSP4,MAP2K1,ATM

255 MIF Regulation of Innate 5,26E-01 1,54E-01 2,449 PLA2G4A,MIF,MAPK3,PLA2G4C,CD14,CD74 Immunity 256 Role of Macrophages, 5,22E-01 1,28E-01 FGF2,CEBPD,HRAS,CCND1,PDGFC,IRAK1,VEGFA,TR Fibroblasts and ADD,IKBKB,CAMK2D,CCL2,PPP3R1,MAPK3,GSK3B, TNFRSF1B,MAP2K1,ATM,TNFRSF11B,SFRP4,MAP3 Endothelial Cells in K14,MIF,NRAS,TNFRSF1A,MYD88,IL15,CREB3,CHP Rheumatoid Arthritis 1,IRAK3,TCF7L1,STAT3,C5,ATF2,CALM1 (includes others),PLCG2,WNT11,IRAK2 257 Role of JAK1, JAK2 and 5,19E-01 1,67E-01 PTPN6,IFNGR2,STAT2,STAT3 TYK2 in Interferon Signaling 258 Superpathway of D-myo- 5,19E-01 1,67E-01 SYNJ2,IMPAD1,SEC16A,PTEN inositol (1,4,5)- trisphosphate Metabolism 259 Thrombopoietin 5,14E-01 1,45E-01 2,121 NRAS,PLCG2,MAPK3,HRAS,IRS2,STAT3,MAP2K1,AT Signaling M 260 CCR3 Signaling in 5,11E-01 1,35E-01 NRAS,PLA2G4C,GNB2L1,GNG2,GNAI1,HRAS,ITPR1, Eosinophils GNG7,CALM1 (includes others),PLA2G4A,CFL2,MAPK3,CCL26,MAP2K1,AT M 261 Small Cell Lung Cancer 5,09E-01 1,41E-01 IKBKB,MAX,TFDP1,CDKN1B,RXRA,CCND1,CDKN2B, Signaling SIN3A,PTEN,ATM 262 Diphthamide 5,09E-01 3,33E-01 EEF2 Biosynthesis 263 NADH Repair 5,09E-01 3,33E-01 APOA1BP 264 Glutathione Biosynthesis 5,09E-01 3,33E-01 GCLM

265 D-glucuronate 5,09E-01 3,33E-01 DCXR Degradation I 266 Methionine Salvage II 5,09E-01 3,33E-01 BHMT2 (Mammalian) 267 1D-myo-inositol 5,09E-01 3,33E-01 IPPK Hexakisphosphate Biosynthesis V (from Ins(1,3,4)P3) 268 S-adenosyl-L- 5,09E-01 3,33E-01 MAT2B methionine Biosynthesis

269 N-acetylglucosamine 5,09E-01 3,33E-01 GNPDA1 Degradation I 270 Protein Ubiquitination 4,99E-01 1,27E-01 CRYAB,HLA- Pathway A,HSPA1A/HSPA1B,HSPB8,HSPA6,UBE2V2,USP54, CDC23,SKP1,DNAJA1,HSPA5,UBE2F,UCHL1,USP3,U SP13,USP47,MED20,UBE2Q1,HSPH1,DNAJC27,PS MC4,USP30,DNAJB9,UBE3A,UCHL3,UBE2G2,UBE2 L3,USP4,USP22,PSMA5,PSMD1,DNAJB6

271 PI3K/AKT Signaling 4,96E-01 1,33E-01 2,673 YWHAG,NRAS,YWHAH,YWHAB,SOS2,HRAS,MAP3K 5,CCND1,PTEN,EIF4EBP1,SYNJ2,IKBKB,MAPK3,CDK N1B,GSK3B,MAP2K1 272 Hereditary Breast 4,94E-01 1,34E-01 HDAC9,NRAS,HRAS,RFC1,RFC5,CCND1,SMARCA4,R Cancer Signaling AD50,NBN,PTEN,FANCE,POLR2C,MSH6,ATR,ATM 273 CNTF Signaling 4,91E-01 1,46E-01 2,646 NRAS,MAPK3,RPS6KA3,HRAS,STAT3,MAP2K1,ATM

274 Apoptosis Signaling 4,89E-01 1,36E-01 -1,508 IKBKB,MAP3K14,NRAS,CAPNS1,TNFRSF1A,PLCG2, MAPK3,HRAS,MAP3K5,CAPN7,TNFRSF1B,MAP2K1

275 Toll-like Receptor 4,88E-01 1,39E-01 1,000 PPARA,IKBKB,MAP3K14,MYD88,MAP3K1,TNFAIP3, Signaling CD14,IRAK3,IRAK1,IRAK2 276 NAD Phosphorylation 4,85E-01 2E-01 ACP6,NADK and Dephosphorylation

277 Dolichyl- 4,85E-01 2E-01 DPM1,ALG6 diphosphooligosaccharid e Biosynthesis 278 Glycine Betaine 4,85E-01 2E-01 SHMT1,BHMT2 Degradation 279 Stearate Biosynthesis I 4,72E-01 1,52E-01 FAM213B,SLC27A2,DBT,ACSL1,ELOVL6 (Animals) 280 FcγRIIB Signaling in B 4,68E-01 1,46E-01 2,236 BLNK,NRAS,PLCG2,HRAS,FCGR2B,ATM Lymphocytes 281 LPS-stimulated MAPK 4,67E-01 1,37E-01 2,333 IKBKB,MAP3K14,NRAS,MAPK3,CD14,HRAS,MAP3K Signaling 5,MAP2K1,ATM,ATF2 282 NF-κB Activation by 4,67E-01 1,37E-01 3,162 IKBKB,MAP3K14,NRAS,MAPK3,MAP3K1,ITGAV,HR Viruses AS,ITGAL,ITGB5,ATM 283 Gαs Signaling 4,58E-01 1,32E-01 1,155 GNB2L1,GNG2,CREB3,LHCGR,CNGA1,GNG7,ATF2, ADRB1,MAPK3,HCK,ADCY7,MAP2K1,PTGER4,ADRB 2 284 D-myo-inositol (1,4,5)- 4,56E-01 1,67E-01 SYNJ2,IMPAD1,SEC16A trisphosphate Degradation 285 Cysteine Biosynthesis III 4,56E-01 1,67E-01 MGMT,MAT2B,CTH (mammalia)

286 Colorectal Cancer 4,55E-01 1,26E-01 1,177 GNB2L1,SOS2,HRAS,CCND1,PDGFC,GNG7,VEGFA,A Metastasis Signaling PPL1,ARRB1,RHOG,RHOB,RHOT1,MAPK3,RHOU,G SK3B,MAP2K1,PTGER4,ATM,NRAS,MMP28,TNFRS F1A,ADRBK2,GNG2,TCF7L1,STAT3,RHOQ,MSH6,AD CY7,WNT11 287 IL-12 Signaling and 4,52E-01 1,3E-01 PPARG,APOE,STAT6,APOB,MYD88,MAF,RAB7A,IRF Production in 1,IKBKB,MAPK3,ZNF668,NCOA1,IRF8,RXRA,MAP2K 1,CLU,ATM Macrophages 288 VEGF Family Ligand- 4,47E-01 1,35E-01 1,897 VEGFA,PLA2G4A,NRAS,PLCG2,MAPK3,SOS2,PLA2G Receptor Interactions 4C,HRAS,MAP2K1,ATM 289 IL-15 Signaling 4,45E-01 1,36E-01 STAT6,IL15RA,NRAS,MAPK3,IL15,HRAS,STAT3,MA P2K1,ATM 290 GABA Receptor Signaling 4,45E-01 1,36E-01 DNM1,NSF,ABAT,UBQLN1,AP1B1,GPHN,ADCY7,AP 2A2,AP2S1 291 Myc Mediated 4,43E-01 1,38E-01 YWHAG,NRAS,IGF1,YWHAH,YWHAB,SOS2,HRAS,A Apoptosis Signaling TM 292 CD28 Signaling in T 4,41E-01 1,31E-01 1,387 CALM1 (includes others),IKBKB,PTPN6,HLA- Helper Cells DRB1,ARPC5L,ARPC2,PPP3R1,CHP1,MAP3K1,VAV1 ,ITPR1,MAP2K1,LCP2,ATM 293 Gap Junction Signaling 4,31E-01 1,28E-01 NRAS,CSNK1G1,TUBB2A,SOS2,GNAI1,HRAS,ITPR1, TUBB2B,ADRB1,SP3,NPR1,PLCG2,PPP3R1,MAPK3, CAV1,MAP2K1,ADCY7,MAP2K5,ATM 294 Role of NFAT in Cardiac 4,3E-01 1,26E-01 1,342 HDAC9,CAMK1,NRAS,CHP1,GNG2,SOS2,GNB2L1,M Hypertrophy AP3K1,GNAI1,HRAS,ITPR1,GNG7,CALM1 (includes others),CAMK2D,IGF1,PLCG2,MAPK3,PPP3R1,GSK 3B,MAP2K1,ADCY7,ATM 295 Role of NANOG in 4,25E-01 1,3E-01 2,333 RIF1,NRAS,BMP4,MAPK3,SOS2,GATA6,HRAS,GSK3 Mammalian Embryonic B,SMAD5,STAT3,TCF7L1,MAP2K1,WNT11,ATM Stem Cell Pluripotency

296 CD27 Signaling in 4,18E-01 1,37E-01 IKBKB,MAP3K14,MAP3K1,MAP3K5,MAP2K1,MAP3 Lymphocytes K3,MAP2K5 297 GADD45 Signaling 4,17E-01 1,58E-01 ATR,CCND1,ATM 298 1D-myo-inositol 4,17E-01 1,58E-01 SYNJ2,SEC16A,IPPK Hexakisphosphate Biosynthesis II (Mammalian) 299 D-myo-inositol (1,3,4)- 4,17E-01 1,58E-01 SYNJ2,SEC16A,PTEN trisphosphate Biosynthesis 300 IL-17A Signaling in 4,14E-01 1,43E-01 IKBKB,CCL2,MAPK3,CEBPD,GSK3B Fibroblasts 301 Creatine-phosphate 4,09E-01 2,5E-01 CKB Biosynthesis 302 2-ketoglutarate 4,09E-01 2,5E-01 DLST Dehydrogenase Complex 303 Heme Degradation 4,09E-01 2,5E-01 HMOX1 304 Phenylethylamine 4,09E-01 2,5E-01 AOC2 Degradation I 305 Myo-inositol 4,09E-01 2,5E-01 IMPAD1 Biosynthesis 306 Biotin-carboxyl Carrier 4,09E-01 2,5E-01 ACACA Protein Assembly

307 Ceramide Degradation 4,09E-01 2,5E-01 ASAH1

308 Rapoport-Luebering 4,09E-01 2,5E-01 BPGM Glycolytic Shunt 309 N-acetylglucosamine 4,09E-01 2,5E-01 GNPDA1 Degradation II 310 Molybdenum Cofactor 4,09E-01 2,5E-01 GPHN Biosynthesis 311 Gαi Signaling 4E-01 1,27E-01 -0,816 RALA,NRAS,NPY1R,SOS2,GNB2L1,GNG2,GNAI1,HR AS,STAT3,GNG7,NPR3,MAPK3,CAV1,ADCY7,AGTR1

312 TR/RXR Activation 3,96E-01 1,29E-01 KLF9,AKR1C1/AKR1C2,ADRB1,AKR1C3,NCOA1,ACA CA,PFKP,PCK1,RXRA,ATM,PPARGC1A 313 CREB Signaling in 3,89E-01 1,24E-01 1,387 NRAS,GNA12,CREB3,SOS2,GNB2L1,GNG2,GNAI1,H Neurons RAS,ITPR1,GNA14,GNG7,ATF2,CALM1 (includes others),POLR2C,CAMK2D,GNA15,PLCG2,MAPK3,M AP2K1,ADCY7,ATM

314 TREM1 Signaling 3,86E-01 1,3E-01 3,000 NLRC5,CCL2,MYD88,PLCG2,MAPK3,LAT2,STAT3,FC GR2B,IRAK1 315 Assembly of RNA 3,82E-01 1,67E-01 GTF3C4,GTF3C3 Polymerase III Complex 316 Ubiquinol-10 3,82E-01 1,67E-01 BCKDHA,BCKDHB Biosynthesis (Eukaryotic) 317 Histamine Degradation 3,82E-01 1,67E-01 ALDH1A3,ALDH7A1

318 Regulation of Actin- 3,8E-01 1,28E-01 0,905 RHOG,RHOQ,RHOB,ARPC5L,RHOT1,ARPC2,PFN4,R based Motility by Rho HOU,PFN2,ARHGDIA,MYL12A 319 Crosstalk between 3,8E-01 1,28E-01 CSF2RB,PRF1,IL15RA,CAMK2D,HLA- Dendritic Cells and DRB1,IL3RA,MICB,HLA-A,IL15,TNFRSF1B,ITGAL Natural Killer Cells 320 RANK Signaling in 3,8E-01 1,28E-01 IKBKB,CALM1 (includes Osteoclasts others),MAP3K14,MAPK3,PPP3R1,MAP3K1,CHP1, MAP3K5,MAP2K1,MAP3K3,ATM 321 Rac Signaling 3,75E-01 1,26E-01 2,496 IQGAP2,NOX4,NRAS,CFL2,ARPC5L,MAPK3,ARPC2, MAP3K1,CYBB,HRAS,MAP2K1,PLD1,ATM 322 UVA-Induced MAPK 3,64E-01 1,26E-01 2,236 PARP16,NRAS,TIPARP,PLCG2,MAPK3,RPS6KA3,HR Signaling AS,PARP3,PARP9,PARP14,ATM 323 TGF-β Signaling 3,64E-01 1,26E-01 1,890 BMP4,NRAS,MAPK3,SOS2,ACVR1,HRAS,SMAD5,TF E3,MAP2K1,ACVR1C,INHBB 324 PXR/RXR Activation 3,62E-01 1,29E-01 PPARA,PCK2,NCOA1,INSR,ALAS1,RXRA,NR3C1,PPA RGC1A 325 Telomerase Signaling 3,55E-01 1,25E-01 2,121 HDAC9,NRAS,ETS2,MAPK3,TEP1,SOS2,HRAS,TERF1 ,MAP2K1,POT1,PTGES3,ATM 326 Fatty Acid Activation 3,4E-01 1,54E-01 SLC27A2,ACSL1 327 Bile Acid Biosynthesis, 3,4E-01 1,54E-01 AKR1C1/AKR1C2,AKR1C3 Neutral Pathway

328 AMPK Signaling 3,39E-01 1,22E-01 -0,905 PFKFB3,LEP,PFKL,PFKP,SMARCA4,EIF4EBP1,AK1,A DRB1,IRS1,ACACA,IRS2,PPM1A,INSR,MLYCD,ATM, ADRB2 329 Role of CHK Proteins in 3,36E-01 1,27E-01 0,000 ATMIN,RFC1,ATR,RFC5,RAD50,ATM,NBN Cell Cycle Checkpoint Control 330 Tetrahydrofolate 3,36E-01 2E-01 MTHFD1 Salvage from 5,10- methenyltetrahydrofola te 331 Serine Biosynthesis 3,36E-01 2E-01 PHGDH 332 dTMP De Novo 3,36E-01 2E-01 SHMT1 Biosynthesis 333 Tyrosine Degradation I 3,36E-01 2E-01 GSTZ1

334 IL-17 Signaling 3,35E-01 1,25E-01 MAP3K14,NRAS,CCL2,MAPK3,HRAS,GSK3B,MAP2K 1,ATM,ATF2 335 Leukocyte Extravasation 3,34E-01 1,2E-01 2,138 CD99,MMP28,CLDN15,CXCR4,GNAI1,CRK,NCF4,IT Signaling GAL,SELPLG,ARHGAP5,CLDN23,EZR,PLCG2,SIPA1,C YBB,VAV1,VCL,DLC1,CTTN,VASP,ACTN1,ATM,MSN

336 Sphingosine-1- 3,34E-01 1,23E-01 0,000 RHOQ,RHOG,RHOB,RHOT1,MAPK3,PLCG2,GNA12, phosphate Signaling RHOU,GNAI1,ADCY7,PDGFC,ASAH1,ATM 337 Synaptic Long Term 3,28E-01 1,21E-01 0,500 NRAS,GNA12,PLA2G4C,GNAI1,HRAS,GNA14,ITPR1, Depression PRDX6,PLA2G4A,GNA15,IGF1,MAPK3,NPR1,PLCG2 ,PNPLA3,MAP2K1 338 Relaxin Signaling 3,28E-01 1,21E-01 PDE12,PDE3A,GNA12,GNB2L1,GNG2,GNAI1,GNA1 4,GNG7,VEGFA,GNA15,MAPK3,NPR1,MAP2K1,AD CY7,APEX1,ATM 339 Cardiac β-adrenergic 3,28E-01 1,21E-01 0,333 PDE12,ADRBK2,PDE3A,PPP1R3C,AKAP9,GNB2L1,G Signaling NG2,PPP1R14A,GNG7,AKAP11,ADRB1,PKIA,APEX1 ,ADCY7,PKIG,AKAP1 340 TNFR1 Signaling 3,28E-01 1,28E-01 2,236 IKBKB,MAP3K14,TRADD,TNFRSF1A,MAP3K1,TNFAI P3 341 CD40 Signaling 3,27E-01 1,25E-01 1,890 IKBKB,MAP3K14,MAPK3,TNFAIP3,STAT3,MAP2K1, MAP2K5,ATM 342 Glycolysis I 3,19E-01 1,36E-01 PFKP,PFKL,BPGM 343 nNOS Signaling in 3,04E-01 1,43E-01 CALM1 (includes others),DAG1 Skeletal Muscle Cells 344 Phenylalanine 3,04E-01 1,43E-01 AASDH,SLC27A2 Degradation IV (Mammalian, via Side Chain) 345 Atherosclerosis Signaling 3,03E-01 1,2E-01 APOE,APOB,CXCR4,PLA2G4C,PDGFC,PRDX6,GLG1, SELPLG,PLA2G4A,CCL2,LPL,PNPLA3,ALOX5,CLU

346 Sertoli Cell-Sertoli Cell 2,98E-01 1,18E-01 MAP3K14,NRAS,CLDN15,TNFRSF1A,TUBB2A,PVRL Junction Signaling 3,MAP3K1,HRAS,MAP3K5,ATF2,TUBB2B,PTEN,CLD N23,PPAP2B,MAPK3,GSK3B,MAGI2,MAP3K3,MAP 2K1,ACTN1 347 TCA Cycle II (Eukaryotic) 2,92E-01 1,3E-01 SDHB,DLST,IDH3B

348 RhoA Signaling 2,91E-01 1,19E-01 2,138 SEPT8,ARPC5L,GNA12,PLD1,ARHGAP5,IGF1,CFL2,P LEKHG5,ARPC2,EZR,PFN2,DLC1,MSN,MYL12A

349 Cell Cycle: G2/M DNA 2,9E-01 1,22E-01 1,000 YWHAG,YWHAH,YWHAB,ATR,SKP1,ATM Damage Checkpoint Regulation 350 Agranulocyte Adhesion 2,89E-01 1,18E-01 CD99,MYH10,MYH9,MMP28,CLDN15,TNFRSF1A,C and Diapedesis XCR4,CKLF,GNAI1,C5,SELPLG,GLG1,CLDN23,CCL13, CCL2,EZR,CCL26,CCL18,CCL19,MSN

351 Breast Cancer 2,82E-01 1,17E-01 CAMK1,NRAS,PPP1R3C,TUBB2A,GNG2,SOS2,GNB2 Regulation by Stathmin1 L1,GNAI1,HRAS,PPP1R14A,ITPR1,TSG101,GNG7,T UBB2B,CALM1 (includes others),CAMK2D,MAPK3,ARHGEF18,CDKN1B,MAP 2K1,ADCY7,ATM 352 Sphingosine and 2,81E-01 1,67E-01 ASAH1 Sphingosine-1- phosphate Metabolism

353 Arginine Biosynthesis IV 2,81E-01 1,67E-01 OAT

354 Proline Biosynthesis II 2,81E-01 1,67E-01 OAT (from Arginine) 355 Urea Cycle 2,81E-01 1,67E-01 ARG2 356 Chondroitin and 2,81E-01 1,67E-01 CHSY1 Dermatan Biosynthesis 357 Selenocysteine 2,81E-01 1,67E-01 SARS Biosynthesis II (Archaea and Eukaryotes)

358 Superoxide Radicals 2,81E-01 1,67E-01 NQO1 Degradation 359 Adenine and Adenosine 2,81E-01 1,67E-01 ADAL Salvage III 360 Purine Ribonucleosides 2,81E-01 1,67E-01 ADAL Degradation to Ribose-1- phosphate

361 GDP-mannose 2,81E-01 1,67E-01 PMM1 Biosynthesis 362 Erythropoietin Signaling 2,8E-01 1,19E-01 PTPN6,NRAS,PLCG2,MAPK3,SOS2,HRAS,MAP2K1,A TM 363 HER-2 Signaling in Breast 2,75E-01 1,18E-01 NRAS,SOS2,HRAS,MAP3K5,CDKN1B,GSK3B,CCND1, Cancer ITGB5,ATM 364 Fatty Acid α-oxidation 2,72E-01 1,33E-01 ALDH1A3,ALDH7A1

365 IL-22 Signaling 2,67E-01 1,25E-01 MAPK3,IL10RB,STAT3 366 Estrogen-mediated S- 2,67E-01 1,25E-01 TFDP1,CDKN1B,CCND1 phase Entry 367 Triacylglycerol 2,67E-01 1,25E-01 LPL,PNPLA3,PRDX6 Degradation 368 Macropinocytosis 2,66E-01 1,18E-01 2,236 NRAS,PLCG2,CD14,HRAS,CSF1R,PDGFC,ITGB5,ATM Signaling 369 TWEAK Signaling 2,64E-01 1,21E-01 2,000 IKBKB,MAP3K14,TRADD,BAG4 370 UVC-Induced MAPK 2,6E-01 1,19E-01 2,236 NRAS,MAPK3,HRAS,ATR,MAP2K1 Signaling 371 Role of PI3K/AKT 2,55E-01 1,17E-01 KPNA3,MAPK3,GNAI1,CRK,GSK3B,MAP2K1,ATM Signaling in the Pathogenesis of Influenza 372 Role of JAK family 2,45E-01 1,2E-01 MAPK3,OSMR,STAT3 kinases in IL-6-type Cytokine Signaling 373 Antigen Presentation 2,44E-01 1,18E-01 NLRC5,HLA-DRB1,HLA-A,CD74 Pathway 374 Tryptophan Degradation 2,44E-01 1,25E-01 ALDH1A3,ALDH7A1 X (Mammalian, via Tryptamine)

375 Putrescine Degradation 2,44E-01 1,25E-01 ALDH1A3,ALDH7A1 III 376 Methionine Degradation 2,44E-01 1,25E-01 MGMT,MAT2B I (to Homocysteine) 377 Mitochondrial L- 2,19E-01 1,18E-01 SLC27A2,ACSL1 carnitine Shuttle Pathway 378 Histidine Degradation III 2,02E-01 1,25E-01 MTHFD1 Supplementary data S4A Adipocytes - upstream regulator analysis of the significantly changed transcripts in the heavier compared with their leaner co-twins Upstream Log Ratio Molecule Type Activati p-value Target molecules in dataset Regulator on z- score 1 TNF 1,281 cytokine 2,993 1,38E-07 AGT,ALDH1A3,ALDH2,APOE,ATP2B1,BC L2,BCL2A1,BID,BTG2,C10orf10,CCL18,C CL4,CCND1,CCND2,CD163,CD274,CD47 ,CDC42EP4,CLASP1,COL16A1,CTSS,CXC L1,CXCL16,CXCL3,CXCL8,CYBA,CYBB,DU SP10,EGR1,FAS,FN1,GADD45A,GPX4,H DAC9,HEXB,HMOX1,IFIT3,IL10,IL15,IL1 7C,IL17D,IL1A,IL1B,IL1RN,IRAK3,ITGAV, JUN,LSS,LYN,MAFF,MFHAS1,MMP9,MV P,NCF2,NEDD9,NFE2L2,NQO1,OAS1,OA S2,OASL,OSMR,PHGDH,PLAU,PLAUR,P MAIP1,PPAP2A,PPARA,PPARG,PPP1R3C ,PRDM1,PRSS23,PSEN1,PTPN12,PTX3,R AB32,RANBP9,RBPMS,RELB,ROBO1,RX RA,SDC4,SELE,SEMA3C,SERPINE1,SOCS 1,STAT1,STAT5A,TGFBR2,TIMP1,TNF,T NFAIP3,TNFRSF11B,TNFSF13B,TSC22D3 ,TYMP,VEGFA,ZNF267

2 SREBF1 transcription 1,86E-07 ACACA,ACADS,CAPZB,DARS,ETHE1,FAS regulator N,GRSF1,HMOX1,HSPA13,HSPA1A/HS PA1B,HSPA5,IRS2,LPIN1,MLYCD,NCF2, OAT,PLS3,PMPCA,RPS24,SUCLG1,TF

3 CCL5 cytokine 3,441 3,30E-07 AHR,ALCAM,C5AR1,CCL4,CCR1,CD163, CD97,CXCL8,DUSP6,IER2,IL1B,MAPK1, MMP9,OLR1,PLAUR,PPIF,SGK1,TPMT,V ASP 4 NR3C1 -0,237 ligand-dependent -2,109 6,49E-07 ACAT1,ADCK3,AKTIP,ALOX5AP,ANGPTL nuclear receptor 4,ANXA1,APOE,APTX,ARRB1,BAG4,BIN1 ,BNIP3L,BOK,BRAF,C1QTNF7,CARD6,CD KN1C,CIDEA,CLK2,CORO1C,CXCL8,DAPK 2,DPF2,DPP7,DUSP22,DYNLL1,F2R,FAST KD1,FN1,FOXO1,FOXO3,GAB1,GADD45 A,GADD45B,GLIPR1,GLUL,HNRNPU,HS D11B1,IFI6,IKBKB,IL15,IL1B,ING1,ITGB2 ,JUND,LGALS12,MALT1,MAP4K3,MAPK 1,MDM4,MYD88,NAV3,NLRP3,NR3C1, NSMAF,OLR1,PDE4B,PEA15,PHLDA2,PP P3CA,PPP3R1,PSEN1,PSMG2,RBMS2,R HOB,RRAGC,SELE,SERPINE1,SGK1,SGPP 1,SH3KBP1,SIAH2,STAT3,STAT5A,STK17 B,TNF,TNFAIP3,TNFRSF10A,TNFRSF11B, TNFRSF12A,TNFSF4,TSC22D3,UBE2K,W DR26,WDR31,YWHAH 5 IL13 cytokine -2,740 6,98E-07 AVPI1,BZW2,C3AR1,CCL18,CD14,CD163 ,CD36,CD48,CISH,CLEC4A,CTNNAL1,CX CL1,CXCL8,CYBB,CYSLTR1,DUSP10,F13A 1,FADS1,FAM162A,FEZ1,G6PD,GAS7,GP X4,HSD11B1,HTRA1,IARS,IL10,IL1B,IL1R N,IRAK3,LILRB2,LTA4H,MAP3K7CL,MS4 A4A,PDGFC,PID1,PIEZO1,PITRM1,PPAR G,RIN2,SLC26A6,SLC43A3,SLC7A7,SOCS 1,ST3GAL6,ST8SIA4,STXBP1,SWAP70,T NF

6 Lh complex 0,941 3,59E-06 ADCY7,ARPC1A,ATP2B1,BNIP3L,CDC42 EP4,CDKN1C,CHUK,CREBL2,DAB2,DHRS 3,EREG,EZR,FDX1,GK,GNAS,GNB1,HSD1 1B1,ITGB5,LHCGR,MAP1LC3B,MAP2K1, MAP3K5,MAP4K4,MAPK6,MAPRE2,M MP9,NLK,P4HA2,PDXK,PGK1,PHKA2,PLI N3,PMAIP1,PPAP2A,PPP2R1A,PPP2R5C ,PPP3R1,PSMD1,PTP4A1,PTPRF,RAB14, RAB1A,RAB2A,RAB31,RHOB,SGK1,STAT 1,STK24,STK25,TNFAIP3,TNFRSF11B,TY RO3,VEGFA

7 CEBPA transcription 0,325 5,00E-06 AKR1B1,ALOX5AP,ANPEP,ANXA1,ASNS regulator ,BCL2,BCL2A1,BTG2,C3AR1,CA2,CCND2 ,CSF1R,CXCL8,FOXO1,GLIPR1,H1FX,HM OX1,IFI6,IL10,IL1RN,ITGAM,ITGB5,KLF 5,NFATC2,OAS2,PTPN3,PTPRC,PTX3,R AB31,RNF144A,SERPINI1,TUBB2A,UBE 2I,VLDLR 8 MYC transcription -0,654 1,36E-05 ACACA,ALCAM,APEX1,BCAT1,BCL6,CA regulator V1,CCND2,CCNE1,CCNG2,CD274,CDKN 1B,CDKN2B,CLU,CSDE1,DDX54,DKC1,E XOSC8,FASN,GADD45A,GADD45B,GIG YF2,GLS,HNRNPU,IQGAP2,JUN,KRAS,L AMP2,MFAP1,MTHFD1,PERP,PLAU,PL AUR,PMAIP1,RCC1,RHOA,RRM2B,SCPE P1,SHMT1,SHMT2,SOX5,TNFRSF10A,T PI1,TXNIP,VEGFA,YTHDC1

9 FSH complex 1,502 1,42E-05 ADCY7,ARPC1A,ATP2B1,BNIP3L,BTG2,C DC42EP4,CDKN1C,CHUK,CREBL2,DAB2, DHRS3,EREG,EZR,FDX1,FILIP1L,GATA6, GK,GNAS,GNB1,HSD11B1,ING1,ITGB5,L HCGR,MAP1LC3B,MAP2K1,MAP3K5,M AP4K4,MAPK6,MAPRE2,MEF2D,MMP9, NLK,P4HA2,PCK1,PDXK,PGK1,PHKA2,PL IN3,PMAIP1,PPAP2A,PPP2R1A,PPP2R5 C,PPP3R1,PSMD1,PTP4A1,PTPRF,RAB1 4,RAB1A,RAB2A,RAB31,RASSF2,RHOB,S GK1,STAT1,STK24,STK25,TFRC,TNFAIP3, TNFRSF11B,TYRO3,VEGFA,ZBED1

10 IKBKB 0,126 kinase 1,234 1,98E-05 CCL4,CXCL8,FYN,IKBKB,IL17C,IL1B,PLA2 G4A,SELE,TNF,TWIST1 11 IFNG cytokine 3,854 2,43E-05 AGT,AIF1,AUTS2,BCL2,BCL2A1,C1QA,C1 QB,C1QC,CCL18,CCL4,CCR5,CD163,CD2 74,CISH,CTSS,CXCL1,CXCL16,CXCL8,CYB B,DDR2,DDX58,DEFB1,DRG1,ERAP2,FA S,FCER1G,FGF2,GNA13,HDAC9,HERC6, HIRA,HSPA1A/HSPA1B,HTRA1,IFI44,IFI6 ,IFIT1,IFIT3,IFIT5,IGFBP4,IL10,IL15,IL1B, IL1RN,ITGAV,JUNB,MMP9,MYD88,NCF 2,OAS1,OAS2,OASL,PLA2G16,PMAIP1,S AMD9,SELE,SMURF1,SOCS1,ST13,STAT 1,THEMIS2,TNF,TNFRSF12A,TNFSF13B, TRIM22,TYMP

12 KRAS 0,222 enzyme 0,111 4,12E-05 BCL2,CCND1,CDKN1B,CXCL8,DUSP4,DU SP6,EREG,FTH1,GADD45A,IL1B,LAMP2, NRAS,PLD1,PSMA7,RPS6,TNFRSF10A

13 JAG2 growth factor -2,043 8,09E-05 BCL6,CCL13,CCR1,CEBPB,CXCL1,CXCL3,I L10RA,IL17C,IL1A,IL1B,IL1RN,MIF,TNF

14 miR-29b-3p mature microrna -1,772 1,13E-04 CNOT8,COL5A2,FRAT2,GAS7,GMFB,HM (and other GN3,MAPRE2,NAV3,PPIC,PURA,SPARC, TUBB2A miRNAs w/seed AGCACCA) 15 TP53 transcription 1,986 1,20E-04 ABCC1,ADRB2,ANXA1,ANXA4,APOE,A regulator RL6IP1,ASXL1,ATG4C,BCL2,BNIP3,BRAF ,BTG2,C12orf5,CAV1,CCNB1IP1,CCNG1 ,CD47,CDKN1B,CERS6,CHUK,CLU,CXCL 1,CXCL8,DBP,DUSP4,EGFL6,FAS,FASN,F BXW7,FDFT1,FOXO1,FYN,GADD45A,GL IPR1,GNA13,HDAC3,HMOX1,HSPA1A/ HSPA1B,IGF1,IL1A,IRS1,JUNB,LPIN1,LS S,MAP2K1,MAP2K7,MAPK1,MCM6,M CM7,MDM4,MGST2,MMP9,MOCOS,M RPL46,MVD,MYO6,OAS1,PDCD6IP,PDE 4B,PERP,PFKFB3,PHKG1,PHLDA3,PLA2 G16,PLAUR,PMAIP1,PPP3CA,PPT1,PTE N,PTP4A1,PTPN11,PTPN12,PTPN6,PYC ARD,RAD23A,RPS27L,RRM2B,S100A4,S EC62,SEL1L,SEMA3C,SERPINE1,SIRT1,SI VA1,SLC19A1,SMURF1,SPATA18,TGFB R2,TMEM97,TNFRSF10A,TRIM22,TSC2, TWIST1,ULK1,VCAN,VEGFA,XPC,YWHA H

16 IL10 0,505 cytokine 1,029 1,48E-04 BCL2,BCL2A1,C10orf10,CCL18,CD14,CD 163,CD274,CHUK,CXCL8,FCGR2B,FCGR 3A/FCGR3B,IKBKB,IL10,IL1B,IL1RN,LILR B2,PDE4B,SOCS1,TIMP1,TNF,VCAN

17 CEBPB -0,127 transcription 0,798 1,48E-04 APOB,ASNS,BCL2,CCL4,CCND1,CCR5,CD regulator KN1B,CDKN2B,CSF1R,CXCL8,GADD45A, HP,IGF1,IL10,IL1B,INSR,NFATC2,PPARG, SGK1,STAT3,VLDLR

18 RAB1B other 0,000 1,79E-04 ARF4,CXCL8,GOLGA3,JUN,KDELR1,KDEL R3,NAPA,RAB32,RHOBTB3,RRAGC,SEC2 4D,STX3,STXBP1 19 CEBPD -0,226 transcription 2,11E-04 ALOX5AP,ASNS,CCND1,CDKN1B,CDKN1 regulator C,CSF1R,CXCL8,IL1B,ITGAM,VLDLR 20 ESR1 ligand-dependent -1,842 2,16E-04 ADORA1,AGT,BCL2,CAV1,CAV2,CCL4,C nuclear receptor CND1,CCNE1,CCNG2,CD69,CEBPB,CSAD ,CTSB,CXCL3,CXCL8,EFEMP1,EREG,FAS, FOSL2,FRAT2,HSPA13,IGF1,IL1A,JUN,KC NK6,KLHL24,MAP2K7,NFYB,NR1D1,PES 1,PPP6R2,PRSS23,PTEN,PTX3,SERPINE1 ,SGK1,SIAH2,SIRT1,STC2,TMEM97,TNF, TNFAIP3,TNFRSF11B,TSC22D3,UQCR10, VEGFA,WNT11,YPEL3

21 HMOX1 0,428 enzyme 0,344 2,49E-04 ANGPT2,CXCL1,CXCL3,CXCL8,FGF1,HM OX1,IGF1,IL10,IL1B,IL1RN,MMP9,TNF,T YMP,VEGFA 22 XIAP enzyme 2,200 2,72E-04 CCND1,CXCL1,CXCL8,PTEN,TNF 23 NDUFA13 enzyme 2,72E-04 BCL2,CCND1,CTTN,MMP9,TFDP1 24 HSF2 transcription 2,72E-04 CLU,HSPA1A/HSPA1B,IL1B,TNF,TXN regulator 25 TGM2 enzyme 4,662 2,97E-04 ACSS2,AQP9,BCL2A1,BCL6,BNIP3,BTG2, C5AR1,CA2,CCND1,CD36,CD93,CXCL8,D APK2,EPB41L4A- AS1,FCER1G,GIMAP2,GM2A,IFI6,IFIT1,I FIT2,IFIT3,IFIT5,IL10RA,IL1B,ITGAM,LIL RB2,MERTK,MMP9,NCF2,OAS1,OAS2,O ASL,PARP9,PNRC1,SAMHD1,SLC27A2,S LC9B2,SMPD1,STAT1,TNF,TPCN1,TRIM 22,TUBGCP5,TYROBP,VSIG4

26 IL17A cytokine 2,996 3,16E-04 BCL2,BCL2A1,CD14,CD163,CD274,CXCL 1,CXCL3,CXCL8,GADD45A,HEXB,IL1A,IL 1B,IL1RN,MMP9,TNF 27 NEUROG1 transcription -1,147 3,23E-04 ADD3,C1S,CCND2,COL3A1,CXCL1,FAM1 regulator 98B,FN1,LCP1,MARC2,MFAP4,MMP9,P 4HA2,PPIC,PXDN,S100A4,SLC43A3,SUL F1,TMTC2,TRIM22 28 PSMD10 transcription 0,707 3,51E-04 CCND1,CXCL1,CXCL8,EIF4EBP1,FNBP1, regulator GNAS,IKBKB,PLD1 29 LIPE enzyme 2,000 3,70E-04 ACSS2,FASN,PC,SLC2A4 30 SAA1 transporter 1,188 3,70E-04 BCL2,CCND1,CXCL8,IL1B 31 C5 -0,485 cytokine 1,816 4,09E-04 BCL2,CXCL8,IL10,IL1B,ITGAM,SERPINE1 ,TNF 32 MAP2K1/2 group -0,118 5,08E-04 CCND1,CDKN1B,DUSP4,EGR1,HSPA5,IL 1B,KLF5,MIR155HG,MMP9,PDGFA,PPA RA,TNF,VEGFA 33 RELA transcription 2,183 5,98E-04 BCL2,BNIP3L,BTG2,CAV1,CCL19,CEBPB, regulator CXCL1,CXCL3,CXCL8,ERAP1,ERAP2,FAS,I FNGR2,IL10,IL1A,IL1B,IL1RN,LYN,MGM T,MMP9,PLD1,PPARG,PTEN,PTPN6,PTX 3,RELB,SLC2A4,STAT5A,TNF,TPMT,TWI ST1,VASP,VEGFA

34 ATF2 transcription 1,000 6,16E-04 ASNS,BCL2,CCND1,DUSP10,FN1,IL10,JU regulator N,PTEN 35 FOXO3 -0,245 transcription -1,117 6,41E-04 BNIP3,CCND2,CCNG2,CDKN1B,CDKN2B, regulator CXCL8,EGR1,EGR2,FOXO1,GADD45A,G ADD45B,MMP9,MXI1,SGK1,TNF,TXNIP 36 IGF1 -0,470 growth factor 2,164 7,06E-04 BCL2,BCL2A1,CCND1,CCNE1,CDKN1B,C XCL8,FN1,IFNGR2,IGF1,IRS1,IRS2,ITGAV ,ITGB5,PLAU,PLAUR,SERPINE1,VEGFA

37 Hsp27 group 1,480 7,40E-04 CCND1,CD14,CD163,CD274,CSF1R,CXCL 8,IL10,IL6R,STAT3 38 miR-155-5p mature microrna -2,761 7,88E-04 CCL18,CCL4,CXCL1,CXCL3,CXCL8,IL1A,IL (miRNAs 1B,KRAS,SERPINE1,SOCS1,TNF w/seed UAAUGCU) 39 P38 MAPK group 2,864 8,32E-04 ANXA5,BCL2,CCNE1,CCNG2,CEBPB,COL 3A1,CXCL8,EGR1,EGR2,FAS,FN1,HMOX 1,IL10,IL1B,ITGAV,JUN,KDELR1,KDELR3, MAP4K4,MIF,MMP9,PLA2G4A,PTPN12, RBP1,SERPINE1,STAT1,TIMP1,TJP2,TNF, ULK1,VEGFA,ZMAT3

40 PRKCA kinase -0,798 9,53E-04 ARPC2,CTSB,EGR1,FN1,HSPA1A/HSPA1 B,JUN,MMP9,MRPL9,NQO1,PHLDA2,PL D1,RHOBTB3,SEC23IP,SERPINE1,VEGFA

41 IgG complex -0,509 1,01E-03 ASAH1,CCL4,CCND2,CD9,CEBPB,CEBPD, CSNK2B,DEGS1,EZR,FCGR2B,GNAS,HSP A5,IER2,IL10,IL1B,IL1RN,JUND,PEA15,P HLDA2,PLAUR,PLS3,PPIF,STK24,TNF,TN FAIP3,TUBB2A,VEGFA,ZMPSTE24

42 SPI1 transcription 1,10E-03 C1QC,CCND2,CD72,CSF2RB,CTSS,CYBB, regulator DUSP6,FTH1,IL1B,IL1RN,NCF2,NCF4,PT PN6,VAV1 43 PDGF BB complex -0,015 1,21E-03 ADRB2,ATP2B1,CEBPB,CXCL8,CYR61,D AB2,DUSP6,EGR1,EGR2,GADD45A,GPR 183,IER2,IL1B,JUN,JUNB,PLAU,PPARG,R GS1,RHOB,SGK1,TNFAIP3

44 ELAVL1 other 1,39E-03 ARG2,CALM1 (includes others),CCNE1,DGAT1,GNB2L1,HMOX1 ,NDUFB8,QARS,RPN2,RPS14,RPS6,SLC2 5A11,SLC7A7,STAT3,TIMM17A,TRIOBP, VAPB 45 STAT3 0,197 transcription 0,823 1,56E-03 AGT,BCL2,C5AR1,CCND1,CD274,CXCL8, regulator EGR2,FN1,GLIPR1,HMOX1,IL10,JUNB,K AT2B,LILRB2,MAP2K5,MMP9,NFATC2,P EX1,PMAIP1,SGK1,STAT1,STAT3,STC2,T IMP1,TNF,TWIST1,VCAN,VEGFA

46 A2M transporter -0,707 1,62E-03 ATF6,BCL2,CCND1,EIF2A,FOXO1,GADD 45B,HSPA5,MAP3K5 47 PSMD4 other 2,000 1,64E-03 CD14,CD36,CD69,MARCO 48 PGF growth factor 1,997 1,64E-03 CCL4,CXCL8,IL1B,TNF 49 ALB transporter -0,000 1,64E-03 AGT,CXCL8,CYBA,VEGFA 50 JUNB -0,224 transcription 2,433 1,69E-03 CD274,FTH1,HMOX1,ITGAV,MMP9,MY regulator L12A,NCF2,PLAUR,SERPINE1 51 IL6 cytokine 0,540 1,80E-03 ABCC1,AGT,APOB,BCL2,CCND1,CCNE1, CD163,CDKN1B,CEBPD,CLU,HP,HSPA5,I L17D,IL6R,ITGB5,JUNB,MAP2K1,MERTK ,PDGFA,PLAU,SGK1,STAT3,TIMP1,TNF, VEGFA 52 FAS 0,352 transmembrane 1,507 1,86E-03 BCL2A1,BID,CEBPD,CXCL1,CXCL8,FAS,F receptor OXO3,JUND,MAP2K5,MMP9,PLAU,TNF AIP3 53 F2R 0,697 g-protein coupled 1,000 1,99E-03 CYR61,F2R,MMP9,RHOA,SELE receptor 54 miR-451a mature microrna -0,316 1,99E-03 AKTIP,BCL2,CCND1,CDKN1B,MMP9 (and other miRNAs w/seed AACCGUU) 55 ANXA1 0,182 enzyme -0,579 1,99E-03 CCR10,FARSA,ITGB1BP1,ITGB2,PLAU

56 NPC1 transporter -1,477 1,99E-03 CAV1,CAV2,STAT1,STAT3,STAT4 57 INS other 0,141 2,09E-03 ACACA,CD36,CIDEA,COX4I1,EGR1,FASN ,INSR,PPARG,TNF,VEGFA,VLDLR

58 Cg complex -0,000 2,18E-03 BCL2,CXCL8,DUSP6,EGR1,EREG,FAS,FJX 1,GATA6,ITGAV,ITGB5,LHCGR,MARCH3 ,NPR3,NRIP1,PFKFB3,PKIA,PLAU,PLAUR ,PMAIP1,PTX3,RECQL,SLC4A4,STC1,VE GFA 59 NFE2L2 0,209 transcription 1,983 2,27E-03 CXCL8,FTH1,FTL,HMOX1,IL10,IL1RN,NQ regulator O1 60 FOXO4 transcription -0,526 2,27E-03 BCL6,BNIP3,CCNG2,CDKN2B,GADD45A, regulator GADD45B,SGK1 61 ITGB1 transmembrane 1,848 2,29E-03 ABCC1,CDKN1B,CXCL8,ITGAV,JUN,JUNB receptor ,MMP9,PLAU,PLAUR,VEGFA 62 HMGA1 transcription 0,584 2,44E-03 CAV1,CAV2,CCND1,INSR,MMP9,MVD,P regulator PARG,STAT3,XPA 63 CCL2 cytokine 0,378 2,46E-03 CXCL8,FOLR2,HTR2B,IGF1,IL1A,SERPINE 1,TIMP1,TNF 64 PGR ligand-dependent 1,002 2,50E-03 AKAP13,AKR1C3,ALDH1A3,BCL6,CALD1 nuclear receptor ,CCND1,CDKN1C,CEBPB,DYNLL1,EIF1AX ,EZR,FN1,GLUL,GSTM3,KLF5,NEDD9,NE T1,PDLIM1,PLAU,PPIF,PTP4A1,RAB9A,R ASSF2,STAT5A,TSC22D3,VASP,VCAN

65 SEL1L 0,155 other 2,67E-03 PTEN,TIMP1,TIMP2 66 MAP3K3 kinase 2,67E-03 CXCL8,JUN,TNFAIP3 67 ABCB7 -0,230 transporter 2,67E-03 FTH1,FTL,TFRC 68 Ap1 complex 1,633 2,79E-03 C3AR1,CCND1,CXCL8,EZR,IL1A,JUN,MM P9,S100A4,SERPINE1,SPARC,TNF

69 Growth group -2,045 2,90E-03 ADRB2,ANGPTL4,BCL2,CCND1,CISH,CIT hormone ED2,DYRK2,FOSL2,NEDD9,NR1D1,PFKF B3,SGK1,SOCS1,TXNIP 70 PF4 cytokine 2,416 3,09E-03 CCL4,CXCL3,CXCL8,IL1A,IL1B,TNF 71 SELPLG other 2,530 3,13E-03 BCL2A1,BST1,CCL4,CXCL8,GNA13,HCK,I GF1,IL10,IL1B,PLAUR 72 EGR1 -0,212 transcription 0,685 3,13E-03 CAV1,CCND2,CXCL8,FN1,GNAS,PDGFA, regulator PPARG,PTRF,TNF,VEGFA 73 CD44 enzyme -0,447 3,42E-03 ADRB2,CCND1,FAS,IL1A,IRAK3,JUN,KD M1A,MMP9,PLAU 74 MYD88 0,186 other 2,579 3,55E-03 CD274,CXCL1,CXCL8,IL15,IL1B,SELE,TNF

75 ATF4 transcription 0,059 3,60E-03 ASNS,CEBPB,JUN,MAP1LC3B,PHGDH,PS regulator AT1,PSEN1,VEGFA 76 IL1RN 0,556 cytokine -3,771 3,68E-03 CTSS,DDX58,ERAP2,HDAC9,HERC6,IFI4 4,IFI6,IFIT3,IFIT5,IL1A,OAS1,OAS2,OASL ,PMAIP1,SAMD9,THEMIS2,TNF,TRIM22

77 MGEA5 enzyme -1,342 3,68E-03 ACSS2,AHNAK2,AKT1S1,AZGP1,BRAF,C AV1,CCND1,CCNG2,CDK10,CNOT1,CXCL 8,DAB2,ELF1,EPHA4,FDFT1,FN1,G6PD, GADD45A,GLUL,GNE,GPT2,GTF2IRD1,IF NGR2,IGBP1,IGFBP4,IL6R,ITGB5,JUN,LP XN,LSS,PDCD6IP,PHKA2,PLA2G16,PLAU ,RAP2A,RHOB,RPS6KA3,S100A6,TCF25, TFDP1,TGFBR2,TIMP1,TIMP2,TSPAN12, WNT11

78 SKP2 other 1,877 3,96E-03 CCND1,CCND2,CDKN1B,FOXO3,PHB2

79 SCD enzyme -0,215 3,96E-03 CEBPB,CXCL3,CXCL8,GADD45A,HSPA5

80 EIF2AK3 kinase -0,562 3,96E-03 ANG,FGF2,MAP1LC3B,PRDM1,VEGFA

81 NOD2 other 3,96E-03 BCL2A1,CXCL8,IL10,IL1B,TNF 82 estrogen group -2,094 4,17E-03 ANXA1,BCL2,CALD1,CAV1,CAV2,CCND1 receptor ,CCND2,CD99,CLDN23,COL12A1,COL6A 1,CXCL1,CXCL8,EREG,F11R,FGF1,FN1,H SPA1A/HSPA1B,IL1A,LYN,MAN1A1,MA P1B,MMP9,MSN,NEDD9,NRIP1,PCDH1 8,PCDH19,PCDHB14,PDGFA,PDGFC,PLA U,PLAUR,SERPINE1,SPARC,TGFBR2,TIM P1,TIMP2,TSC22D3,VEGFA

83 IL4 cytokine 0,279 4,34E-03 CCL18,CCR5,CD14,CD163,CD69,CDKN1 B,CISH,CXCL8,CYSLTR1,FCGR2B,GPX4,IL 10,IL1B,MMP9,NFATC2,PDE4B,PPARG, PRDM1,SOCS1,TIMP2,TNF,TNFSF4

84 PRKCZ kinase -0,025 4,39E-03 LHCGR,PHGDH,PSAT1,VEGFA 85 HFE transmembrane 4,39E-03 HSP90B1,HSPA5,TF,TFRC receptor 86 PPARG -0,206 ligand-dependent 0,015 4,46E-03 ANGPTL4,CAV1,CAV2,CCND1,CXCL8,FN nuclear receptor 1,IL10,IL1B,MMP9,PPARA,PTEN,SERPIN E1,TGFBR2,VEGFA

87 EIF2AK2 kinase 2,703 4,53E-03 BCL2,CEBPD,CXCL8,DDX58,ERAP2,IFI6,I FIT1,IFIT5,IRS2,NEDD9,OAS1,PARP9,SA MHD1,STAT1,TNFAIP3 88 ATM kinase 0,816 4,70E-03 ALKBH8,CLU,CXCL8,GADD45A,GADD45 B,GADD45G,LPIN1,PPP2R5D,TNFAIP3

89 Gsk3 group -0,453 4,70E-03 BCL2,CCND1,CXCL8,FASN,IL10,IL1B,JUN ,TNF,TNFAIP3 90 SIRT1 -0,307 transcription -0,692 4,70E-03 BNIP3,CCND2,CCNG2,FN1,FOXO3,HMO regulator X1,IGF1,MMP9,NAT1 91 MAX transcription 2,000 4,75E-03 APEX1,BCL6,CCND2,CCNG2,CDKN2B,CS regulator DE1,DKC1,GADD45A,GADD45B,MTHFD 1,TXNIP 92 CLDN7 other 0,000 4,77E-03 AGT,C1S,CKAP4,CXCL8,DENND5A,DNAJ B6,GLS,GRINA,MCU,MMP9,MRPL40,M RPS15,NUDT21,PHGDH,PLA2G16,PSMG 2,RNASET2,SLC25A22,TPK1,WIPI1 93 KLRC4- transmembrane 0,160 5,07E-03 IL10,PPARG,RXRA,TNF,TNFSF4,VEGFA KLRK1/KLRK1 receptor

94 miR-30a-3p mature microrna -0,954 5,07E-03 ANKFY1,HELZ,KIF1B,MCCC2,RAB8B,WD (and other R44 miRNAs w/seed UUUCAGU) 95 SOCS3 phosphatase -2,415 5,07E-03 BCL2,IFIT1,IFIT2,OAS1,OAS2,TNF 96 CSF1 cytokine 1,254 5,12E-03 CCND1,CD163,FAS,FN1,IL10,IL1B,STAT1 ,VEGFA 97 PRKCE kinase 0,397 5,12E-03 BCL2,CAV1,CCND1,EGR1,MMP9,PDGFA ,STAT3,VEGFA 98 MTA1 transcription 5,33E-03 ADRB2,CCND1,CCND2,CDKN1C,MMP9, regulator RNF144A,SIRT1 99 IFNL1 cytokine 3,931 5,42E-03 CXCL8,DDX58,HERC6,IFI44,IFI6,IFIT1,IFI T2,IFIT3,IFIT5,IL10,OAS1,OAS2,OASL,SA MD9,STAT1,TRIM22 100 IL18 cytokine 2,448 5,47E-03 ADAMTS5,BCL2,BSG,CCL4,CXCL8,FAS,IL 10,IL1A,IL1B,MMP9,PTEN,TGFBR2,TIM P1,TNF 101 IFNA2 cytokine 3,166 6,43E-03 CISH,CYB5A,DDX58,FAS,FGF2,HERC6,IFI 44,IFI6,IFIT1,IFIT2,IFIT3,IFIT5,IL10,LILRB 2,MMP9,OAS1,OAS2,PMAIP1,SOCS1,ST AT1 102 PI3K (family) group 1,861 6,59E-03 AKR1C1/AKR1C2,CCNG2,CD274,CXCL8, FASN,FOXO1,HMOX1,HSPA5,IL10,MMP 9,NFE2L2,NQO1,TNF,TXNIP,VEGFA

103 IL32 cytokine 1,606 7,02E-03 BCL2,CXCL1,CXCL8,IL1B,TNF 104 LIPG enzyme 0,070 7,02E-03 BCL2,CD36,IL1B,TNF,VEGFA 105 LY6E other -1,522 7,02E-03 CD14,CXCL8,IL1B,RELB,TNF 106 IL1B 1,020 cytokine 2,834 7,04E-03 AKR1B1,AMPD3,APOB,APOE,BCL2A1,C CL13,CCL4,CEBPB,CTSS,CXCL1,CXCL3,C XCL8,EGR1,FAS,FGF2,HEXB,HNF1B,IL10, IL15,IL1B,IL1RN,INSR,ITGAM,LCP1,MIF, MMP9,PLA2G4A,PPARG,PSEN1,PTGFR, PTX3,RXRA,SELE,SERPINE1,SRGN,TNF,V EGFA 107 ERK1/2 group 0,499 7,49E-03 ARRB1,ASAH1,CCL4,CCND1,CDKN1B,CE BPB,COL3A1,CXCL3,CXCL8,EGR1,EZR,F GF2,FOXO1,HSPA5,IFIT1,IL1A,IL1B,JUN, JUNB,MKNK1,SGK1,TIMP1,TNF,VEGFA

108 LDL complex 0,738 7,67E-03 APOE,CD36,CETP,ECE1,HSP90B1,HSPA5 ,IL1B,OLR1,PPARG,SERPINE1,TNF

109 AKT1 kinase 2,621 7,68E-03 AKR1C1/AKR1C2,CDKN1B,CIDEA,FOXO 1,HMOX1,NFE2L2,NQO1 110 IKBKE kinase 0,883 7,84E-03 BCL2,CCND1,CXCL8,IFIT1,IL1A,MMP9

111 CD24 other -1,732 8,02E-03 ADD3,ADRB2,CAV1,CTTN,CXCL8,EDEM 3,FRYL,FXR1,HSPB8,IRAK1BP1,KLHL22,L RPPRC,NCOA3,NRIP1,OASL,PLAU,PTP4 A1,RELB,RSBN1,SLC4A4,SPG11,TRAFD1, ULBP2 112 HGF growth factor 0,946 8,58E-03 ARPC5,CCNG2,COPB1,CXCL8,DGCR14,E GR1,IGF1,INPPL1,MERTK,NRIP1,NUMA 1,PDGFA,PGK1,PLAU,PLAUR,PLOD1,PN RC1,RARRES2,RHOB,SNRNP70,TMEM9 7,VEGFA 113 FOXO1 -0,193 transcription -1,016 8,65E-03 CCNG2,CDKN1B,CDKN1C,CDKN2B,CXCL regulator 8,EGR1,EGR2,FOXO1,GADD45A,GADD4 5B,IRS2,LEFTY2,MMP9,PCK1,SGK1,TNF, TXNIP 114 TLR3 transmembrane 1,946 9,05E-03 CXCL8,DDX58,DEFB1,IFI44,IFI6,IFIT1,IFI receptor T2,IFIT3,IL10,IL15,IL1B,MYD88,OAS1,O ASL,PMAIP1,PTX3,STAT1,TNF,TNFSF13 B 115 FASN -0,540 enzyme -0,577 9,11E-03 CXCL8,FASN,IL10,TNF 116 SP1 -0,145 transcription -0,556 9,30E-03 ASNS,ATP6V0C,B4GALT5,BCL2,CAV1,CC regulator ND1,CDKN1B,CDKN2B,CEBPB,CEBPD,CS NK2A1,CTH,CXCL8,EGR1,EZR,F2R,FGF2, FN1,GNAS,HADHA,HADHB,HMOX1,HSP A5,ID4,IL10,IL15,INSR,ITGAV,JUN,LHCG R,NCF2,PLAU,PLAUR,SLC19A1,SLC31A1, SMPD1,SOCS1,SP1,STAT1,TGFBR2,TNF, TXNRD1,UGDH,VEGFA

117 Pkg group 9,56E-03 BCL2,JUN,TXN 118 caspase group 9,56E-03 BCL2,CCND1,CD14 119 STK40 kinase 9,56E-03 CXCL1,CXCL8,IL1B 120 PRKDC kinase 9,56E-03 AHR,EGR2,NR1D1 121 AREG growth factor 9,56E-03 BCL2,CCND1,PLAU 122 FANCA other 9,56E-03 EGR1,IL1B,TNF 123 ZNF148 transcription 9,56E-03 FN1,ITGAM,STAT1 regulator 124 PYCARD 0,530 transcription 9,56E-03 CXCL8,DUSP10,IL1B regulator 125 ITGAM 1,009 transmembrane 9,56E-03 CCL4,CXCL8,IL1B receptor 126 CTSB 0,237 peptidase 9,56E-03 CTSB,IL1B,PLAUR 127 CD163 1,398 transmembrane 9,56E-03 HMOX1,IL1B,TNF receptor 128 ADORA2B g-protein coupled 9,56E-03 BCL2,CXCL8,VEGFA receptor 129 ITGAX transmembrane 9,56E-03 CCL4,CXCL8,IL1B receptor 130 IRAK2 kinase 9,56E-03 CXCL8,IL1B,TNF 131 CRTC1 transcription 9,56E-03 NEDD9,NQO1,PER1 regulator 132 GNA15 0,293 enzyme 9,56E-03 CD69,CXCL8,IL10 133 CD40LG cytokine 2,316 1,04E-02 ANXA7,BCL6,CCL18,CD69,CDKN1B,CXC L8,FAS,FCGR2B,IL10,IL1A,IL1B,NCOA3,P LEK,SP1,STAT1,TFRC,TNF,TNFAIP3,VEG FA 134 HIF1A transcription -1,443 1,08E-02 AGT,ANGPTL4,APOE,ARPC2,ATG9A,BNI regulator P3L,CAV1,CCND1,CHKA,CTPS1,CXCL8,C YR61,EIF4E,FN1,GADD45B,HDAC3,IGF1, IRS2,ITGB2,KDM4B,LOC100287166,LOX ,MMP9,P4HA2,PFKFB3,PPARA,SDC4,SE RPINE1,STC2,TFRC,TMEM19,TMEM45A ,VASP,VEGFA

135 DICER1 enzyme 1,10E-02 ANGPT2,ANGPTL4,ANPEP,C10orf10,CX CL8,CYR61,GNG2,PLAU,RTN1,SERTAD4, SFRP4,SLC4A4,SPARC,TNF,TRIM6

136 CD40 transmembrane 1,348 1,10E-02 BCL2A1,BCL6,CDKN1B,CXCL8,CYSLTR1, receptor FAS,FCGR2B,IL10,IL1A,IL1B,IL1RN,IL6R, PRDM1,SAMSN1,TNF,TNFSF13B,VEGFA ,ZBTB16 137 PLAUR 0,674 transmembrane 2,224 1,14E-02 C5AR1,CTSB,ITGAM,PLAU,PLAUR receptor 138 WNT5A cytokine 1,231 1,14E-02 BCL2,CXCL8,FN1,IL10,IL15 139 PHB2 -0,263 transcription -0,555 1,14E-02 CDKN1C,SOCS1,SOCS5,STAT3,TXN regulator 140 F2 peptidase 1,195 1,15E-02 CCND1,CDKN1B,CXCL8,EGR1,FN1,MMP 9 141 TRIB3 kinase -1,673 1,15E-02 ASNS,CTH,GARS,PMAIP1,PSAT1,STC2

142 FANCC other 1,17E-02 AQP9,HNF1B,IL1B,MYOF,NR3C1,OAS1, OAT,PHLDA2,PTPRC,PTX3,SKAP2,TNF,T NFSF4 143 CD3 complex -2,233 1,24E-02 BCL6,CCL4,CCND2,CD69,CDKN1B,CXCL 8,EGR2,FAS,IL10,ORAI3,PDE4B,PHB2,PP ARG,RNF128,RXRA,SP1,STAT1,TFRC,TH Y1,TNF,TNFAIP3,VEGFA

144 FGF2 -0,273 growth factor -1,188 1,38E-02 CDKN1B,EGR1,FGF2,MGMT,MMP9,PPA RG,SELE,SERPINE1,VEGFA 145 SOCS1 -0,356 other -1,505 1,38E-02 BCL2,CCND1,CCNE1,DDX58,IFIT1,IFIT2, OAS1,OAS2,SOCS1 146 ETS1 transcription 0,669 1,43E-02 ARPC2,B4GALT5,CCNE1,CHUK,DNAJA3, regulator FN1,HSPA1A/HSPA1B,MMP9,MRPL9,N QO1,PHLDA2,PLAU,PSEN1,RHOBTB3,SE C23IP,SP1 147 PRKCD kinase 1,045 1,43E-02 CCND1,CXCL8,HRH1,IL1B,ITGAM,KLF5, MMP9,RELB,SERPINE1,STAT3 148 CSF2 cytokine 1,960 1,45E-02 CCL18,CCR1,CD69,CSF2RB,CXCL8,CYBB, DUSP6,EGR2,FCGR2B,GK,IL10,IL1B,MK NK1,NACA,PPIF,SLC1A5,TNF,TPM4

149 IL33 cytokine 0,872 1,46E-02 ACAT1,APOE,CD36,CXCL8,IL1B,ITGAM, TNF 150 TCR complex 1,273 1,53E-02 BCL2A1,BSG,CD200,CD69,CISH,CTSB,CX CL8,CYTIP,DDX58,IFI44,IFI6,IFIT1,IFIT2,I FIT3,IL10,JUN,MYD88,NR3C1,OAS1,OAS L,PGK1,PMAIP1,PTPRC,RELB,SIAH2,SOC S1,STAT1,STAT5A,TNF,TNFAIP3,TNFRSF 12A,TNFSF13B 151 TP63 transcription 0,340 1,60E-02 CAST,CCND1,CCND2,CDKN2B,CITED2,C regulator XCL8,CYR61,DAP3,DUSP10,F2R,FAS,FAS N,FBN1,FN1,GADD45A,HIRA,IL1B,LYN, MIR155HG,PLAU,PMAIP1,PTEN,PTPN1 2,RCC1,S100A4,TNFRSF10A,ULBP2

152 FCER1G 0,785 transmembrane 2,000 1,62E-02 CXCL8,IL1B,IL1RN,TNF receptor 153 LILRA2 other 1,067 1,62E-02 CXCL8,IL10,TNF,TYRO3 154 FCGR2A transmembrane 1,030 1,62E-02 CCL18,IL10,IL1B,TNF receptor 155 MEMO1 other 0,000 1,62E-02 CA2,CCND1,JUN,STC2 156 mir-515 microrna -1,053 1,62E-02 ANGPTL4,CXCL8,SERPINE1,TGFBR2 157 ILK kinase 1,62E-02 BCL2,CNKSR3,FN1,TNF 158 ZBTB17 transcription 1,62E-02 CDKN1C,CDKN2B,PMAIP1,RRM2B regulator 159 F7 peptidase -0,426 1,64E-02 CXCL8,EGR1,GADD45A,IER2,IL1B,KLF5, PLAUR,VEGFA 160 FOXA1 transcription -2,642 1,65E-02 ALDH6A1,ANXA1,FNDC3B,FSTL1,GLS,H regulator NF1B,KDM4B,LYN,MALT1,NDUFV3,NRI P1,PAM,PPARA,SIAH2,TF,TNFRSF12A

161 IL21 cytokine 0,674 1,65E-02 BCL6,BSG,CCR10,CD69,FCGR2B,IL10,M MP9,MYD88,PRDM1,PTPRC,SOCS1,TNF ,TYROBP 162 IL5 cytokine 1,155 1,71E-02 CCR1,CD69,CSF2RB,DUSP6,EGR2,FCGR 2B,GK,MKNK1,NACA,PPIF,SLC1A5,TPM 4 163 GAPDH enzyme -0,705 1,73E-02 CCL4,CXCL1,FCER1G,IFI6,IFIT2,IL10,OAS 1,OAS2,STAT1 164 IFN Beta group 1,73E-02 CLK2,FN1,IFI6,IFIT1,OAS2,SOCS1,SPRY1, STAT1,TXNRD1 165 SHC1 kinase 2,224 1,74E-02 BCL2,FTH1,FTL,NQO1,TXN 166 TNFRSF1A transmembrane 2,200 1,74E-02 CXCL1,CXCL8,IL1B,NFE2L2,NQO1 receptor 167 Ctbp group 1,74E-02 ADRB2,CCND1,PLAUR,RAB29,SIRT1

168 IL12 complex 1,093 1,75E-02 CCL4,CD69,IL10,ITGB2,MMP9,MYD88,P (complex) LAU,STAT4,TGFBR2,TIMP1,TNF 169 AR ligand-dependent -0,457 1,81E-02 ACTR3,AKR1C3,ARHGEF7,AZGP1,CAST, nuclear receptor CAV1,CAV2,CKAP4,CTSO,EGR1,EPB41L4 B,IGF1,KDM4B,LRRK1,PLS3,RHOB,SERPI NE1,SLC43A1,STAT1,TGFBR2,TNFRSF12 A,VCAN,VEGFA 170 JUN -0,126 transcription 1,825 1,90E-02 ASNS,C3AR1,CD274,CXCL1,CXCL8,EREG regulator ,FTH1,HMOX1,IL1A,IL1B,ITGAV,JUN,JU NB,MMP9,NCF2,PEA15,PLAUR,PTX3,SE RPINE1,TNF,VEGFA 171 CD300LF other 1,92E-02 CXCL8,MMP9 172 VTCN1 other 1,92E-02 CCND1,CCNE1 173 POPDC2 other 1,92E-02 IL1B,TNF 174 STAB1 transporter 1,92E-02 IL10,TNF 175 ZFP91 0,105 transcription 1,92E-02 CCL19,TNFSF13B regulator 176 KLHL2 0,192 other 1,92E-02 CCND1,JUN 177 ZNF385B other 1,92E-02 FAS,PERP 178 CYSLTR2 g-protein coupled 1,92E-02 CXCL8,CYSLTR1 receptor 179 hemoglobin complex 1,92E-02 CD163,CXCL8 180 TRPM2 ion channel 1,92E-02 CXCL8,TNF 181 NODAL growth factor 1,92E-02 CCNG2,FOXO3 182 DLX4 transcription 1,92E-02 FGF2,VEGFA regulator 183 DAB2IP other 1,92E-02 CLU,EGR1 184 mir-183 microrna 1,92E-02 EGR1,PTEN 185 ADAM12 0,430 peptidase 1,92E-02 JUNB,SERPINE1 186 NUBP1 other 1,92E-02 FTH1,TFRC 187 FTL 0,102 enzyme 1,92E-02 FTH1,TFRC 188 CD74 transmembrane 1,92E-02 BCL2,CXCL8 receptor 189 DNAJA3 -0,160 other 1,92E-02 CXCL8,VEGFA 190 GNA13 0,176 enzyme 1,92E-02 CXCL8,VEGFA 191 VCP enzyme 1,92E-02 BCL2,CXCL8 192 PIWIL2 other 1,92E-02 CCND1,STAT3 193 CCR1 0,803 g-protein coupled 1,92E-02 CCR1,MMP9 receptor 194 HP 0,768 peptidase 1,92E-02 CD163,HMOX1 195 IREB2 translation 1,92E-02 FTH1,TFRC regulator 196 FTH1 0,388 enzyme 1,92E-02 FTL,TFRC 197 BRD2 -0,192 kinase 1,92E-02 HMOX1,NQO1 198 CREB3L1 transcription 1,92E-02 HSP90B1,HSPA5 regulator 199 FOXP1 other 1,92E-02 CSF1R,ITGAM 200 mir-155 microrna 0,570 1,93E-02 CCL18,CEBPB,IL1B,SERPINE1,SOCS1,ST AT3,TNF 201 IL1A 1,306 cytokine 2,925 2,02E-02 ALDH1A3,CD274,CXCL1,CXCL3,CXCL8,F GF2,HSD11B1,IL1A,IL1B,LOX,PDGFA,PL AU,PTX3,SERPINE1,TNF,TNFAIP3,TNFRS F11B 202 OSM cytokine 0,299 2,08E-02 ABCC1,ANGPT2,HSPA5,IL1B,IL6R,OSMR ,TNF,VEGFA 203 TRIM38 other 2,14E-02 CXCL8,IFIT2,TNF 204 HLA-DQ complex 2,14E-02 IL10,IL1B,TNF 205 TIRAP other 2,14E-02 CXCL8,IL15,TNF 206 PROK2 other 2,14E-02 BCL2,IL1B,VEGFA 207 miR-31-5p mature microrna 2,14E-02 CXCL1,CXCL8,IL1B (and other miRNAs w/seed GGCAAGA) 208 FCER2 transmembrane 2,14E-02 CCL4,CXCL8,TNF receptor 209 CXCR3 g-protein coupled 2,14E-02 BCL2,HMOX1,MAP1LC3B receptor 210 NFIL3 transcription 2,14E-02 FAS,GADD45A,GADD45B regulator 211 JAK3 kinase 2,14E-02 CD274,IL10,TNF 212 S100A7 other 2,14E-02 CXCL1,CXCL8,IL1A 213 STAT5a/b group 1,492 2,14E-02 AHR,CD69,CDKN2C,CISH,EPHA4,LCP2,P DE4B,RBP1,STK17B 214 TERT enzyme 0,845 2,14E-02 CAV1,CCND1,CCNE1,CXCL8,EREG,FGF2, IL1B,MMP9,RAB9A 215 ESRRA ligand-dependent -0,849 2,14E-02 ATP5B,CSAD,FRAT2,NDUFA1,NDUFB5,N nuclear receptor R1D1,PKM,TPI1,WNT11

216 JAK2 kinase 2,425 2,24E-02 CCND2,CD36,CDKN1B,CYBB,LYN,RBP1

217 NPC2 other -0,686 2,24E-02 AKR1C3,PLA2G4A,PPARG,STAT1,STAT3, STAT4 218 IL27 cytokine 1,006 2,27E-02 C10orf10,CCL4,CD14,CD163,CXCL8,IL10 ,IL1A,IL1B,IL1RN,ITGAM,SOCS1,STAT1,T NF 219 EGF growth factor 0,108 2,27E-02 CEBPB,CEBPD,CXCL8,DUSP6,EGR1,FAS N,LHCGR,MMP9,PPARG,S100A10,SERPI NE1,TGFBR2,VEGFA 220 ANXA2 other -0,342 2,50E-02 ANG,FAS,GADD45A,JUN,PTEN,TNF,ZMA T3 221 MAPK8 kinase -0,816 2,50E-02 CDKN1B,FOXO1,JUN,MMP9,PTEN,PTX3 ,RBP1 222 APOE -0,605 transporter 2,50E-02 CALU,COX6B1,DDT,FYN,SIRT1,SLC25A6, TUG1 223 miR-16-5p mature microrna 0,391 2,51E-02 BCL2,CCND1,CCNE1,FGF2,PURA (and other miRNAs w/seed AGCAGCA) 224 BACH1 transcription -1,109 2,51E-02 CALM1 (includes regulator others),EWSR1,FTH1,HMOX1,NQO1 225 MNT transcription 2,000 2,61E-02 BCL6,CCNG2,GADD45B,TXNIP regulator 226 SYK kinase 1,165 2,61E-02 CCND1,CD69,CXCL8,TNF 227 BSG -0,297 transporter 1,109 2,61E-02 BSG,CXCL8,MMP9,TNF 228 ITGB2 0,543 transmembrane 1,067 2,61E-02 CCL4,CD69,RAC1,TNF receptor 229 FH enzyme 2,61E-02 AATF,AKR1C1/AKR1C2,NQO1,TKT 230 CXCL8 0,786 cytokine 1,467 2,61E-02 CD69,COL12A1,CXCL8,IL1B,ITGAM,ITGB 2,MMP9,RAC1 231 Gm-csf group 0,000 2,63E-02 BCL2,CCND2,CD14,CD163,CXCL8,IL10,IL 1B,MMP9,TNF 232 RAF1 kinase 2,191 2,97E-02 BCL2,FAS,IL10,IL1B,MMP9,TNF 233 TNFSF10 cytokine 2,174 2,97E-02 BCL2,CD14,CXCL8,IL1RN,ITGAM,JUN

234 JUND -0,229 transcription 2,97E-02 AGT,CCND1,FTH1,HMOX1,MMP9,NCF2 regulator 235 TP73 transcription -1,372 3,02E-02 ABCC1,BID,CCNG2,CDKN1B,COL5A2,CO regulator X4I1,CTH,DBP,DHRS3,FAS,FASN,FGF2,F XR1,G6PD,GAB2,IDH2,IGFBP4,MFAP3,P MAIP1,PNRC1,PTPN3,TWIST1,UBL3,VE GFA 236 IGF1R transmembrane 1,254 3,17E-02 CDKN1B,IFNGR2,IGF1,ITGAM,LHCGR,R receptor AC1,RHOA 237 TSPYL5 other 3,17E-02 CAST,F11R,FBXW7,MRPL39,NR3C1,RW DD3,USP24 238 MAP2K1 0,283 kinase 1,066 3,18E-02 BCL2A1,CD274,DUSP6,HSPA5,JUND,M MP9,PLA2G4A,RRAGD,SP1 239 NEDD9 0,192 other -0,333 3,18E-02 BNIP3,ERRFI1,MKNK2,MMP9,PCK1,PGK 1,SERPINE1,STC1,TXNIP 240 HRAS enzyme 1,432 3,22E-02 BCL2,CDKN2B,CXCL8,FAS,HMOX1,IL1B, SP1,TNFRSF10A 241 HIC1 transcription 0,577 3,26E-02 ADRB2,AHNAK2,CA2,CCND1,CDKN1C,F regulator ADS1,GRSF1,ID4,KIAA0895,MAP2K5,PL A2G4A,RIN2,SIRT1,SRGN 242 EPAS1 transcription -1,578 3,29E-02 ANGPTL4,C1QA,CAV1,CHKA,CKB,GLS,IR regulator S2,ITIH5,KDM4B,LOX,PFKFB3,SERPINE1 ,SF3A3,SLC6A8,STC2,TMEM45A,VEGFA

243 SOX11 transcription -2,376 3,43E-02 ADAM9,CAV1,CD9,EBF1,EGR1,FAS,IER2 regulator ,IGIP,PAG1,PDGFA,PRDM1,SKAP2,SOCS 5,STAT1,YPEL1 244 PDLIM2 other 2,065 3,46E-02 BST1,C4orf19,CITED2,CXCL8,FHDC1,FST L1,GHR,GNG2,IFI44,IFIT3,NPR3,PHLDA3 ,PPP1R14A,RNF128,RTN1,SLC43A3,STC 2,TXNIP,YPEL3 245 CD14 0,554 transmembrane 2,219 3,46E-02 CCL4,IFIT1,IL10,IL1B,TNF receptor 246 TLR1 transmembrane 2,215 3,46E-02 CXCL8,IL15,IL1B,TNF,TNFAIP3 receptor 247 mir-21 microrna 0,493 3,46E-02 IRAK1,MYD88,PPARA,PTEN,STAT3 248 HOXD10 transcription 0,447 3,46E-02 EZR,RHOB,SERPINE1,TIMP1,TIMP2 regulator 249 BCL11B other 0,391 3,46E-02 ADORA1,CXCL8,NCEH1,SPRY1,TNF 250 MAPK9 kinase 0,194 3,76E-02 ACACA,CAV1,CDKN1B,FASN,GADD45B,I ER2,JUNB,PLA2G4A,PPARG,PTEN,PTX3, RAC1 251 Hsp70 group 3,85E-02 BCL2,CXCL8,TNF 252 Fc gamma group 3,85E-02 CCL18,CCL19,CXCL8 receptor 253 SIRT6 enzyme 3,85E-02 CXCL8,IL1A,TNF 254 ITGA5 transmembrane 3,85E-02 CCND1,JUN,JUNB receptor 255 GPER1 g-protein coupled 3,85E-02 ASAH1,CCND1,FASN receptor 256 TNFAIP3 0,377 enzyme 3,85E-02 CHUK,CXCL8,TNF 257 TNFRSF18 transmembrane 3,85E-02 CXCL8,MMP9,TNF receptor 258 SH3KBP1 -0,183 other 3,85E-02 BCL2A1,CCND2,PRDM1 259 STK4 kinase 3,85E-02 BCL2,FAS,FOXO1 260 GPI -0,174 enzyme 3,85E-02 FN1,RAC1,RHOA 261 S100A8 other 3,85E-02 CXCL8,IL1B,TNF 262 NR3C2 ligand-dependent 3,85E-02 CNKSR3,SGK1,TSC22D3 nuclear receptor

263 TLR5 transmembrane 2,000 3,87E-02 CXCL8,IL10,IL15,TNF receptor 264 IGFBP5 other 1,997 3,87E-02 BCL2,CCND1,IRS1,SERPINE1 265 TRAF6 enzyme 1,982 3,87E-02 CD274,CXCL8,IL10,IL15 266 MIF 0,235 cytokine 1,236 3,87E-02 CXCL8,IL1B,JUN,TIMP1 267 TICAM1 other 1,000 3,87E-02 CXCL8,IFIT1,IFIT2,TNF 268 LPL enzyme 0,450 3,87E-02 BCL2,IL1B,TNF,VEGFA 269 mir-373 microrna -1,053 3,87E-02 ANGPTL4,CXCL8,SERPINE1,TGFBR2 270 TYK2 kinase 3,87E-02 C5AR1,CD274,CD36,LILRB2 271 SYVN1 transporter 2,746 3,92E-02 ADAM9,AHR,BCAT1,CALM1 (includes others),CCND1,CRTAP,CTPS1,DAB2,DCT N1,FASN,IFI44,ITGAV,MED25,MYOF,NU DT21,OLR1,PNPLA2,POLR2B,PTRF,RPN 2,SLC1A5,SLC39A10,SLC43A2,SLC43A3, SLCO4A1,TFRC

272 TCF4 transcription 3,93E-02 CCND1,FGF1,JUN,PLAU,PSD3,SGK1,USP regulator 12,VCAN 273 Hdac group 0,480 4,02E-02 BCL6,CCND1,CCNG2,CSF1R,CXCL8,EGR 1,GADD45B,JUN,TGFBR2,TNFSF4,TXNIP

274 BCL6 -0,182 transcription -0,115 4,32E-02 ALCAM,BCL6,CCND1,CCND2,CD69,CD7 regulator 2,DUSP6,FTH1,MIR155HG,PRDM1,SERP INE1,SOX5 275 PRL cytokine 1,422 4,62E-02 BCL2,CCND1,CD69,CPD,CTSB 276 NRG1 growth factor 0,626 4,62E-02 BCL2,CCND1,CCNE1,CYR61,ITGAV 277 STAT2 transcription 4,62E-02 CCL19,IFI6,IFIT2,OAS1,OAS2 regulator 278 NFKBIA transcription 4,62E-02 CXCL8,IL1B,MMP9,TNF,VEGFA regulator 279 IFNB1 cytokine 1,168 4,73E-02 CXCL8,FGF2,IFIT1,IFIT3,IL10,MMP9,OAS 2,STAT1 280 NR1H4 ligand-dependent -0,649 4,73E-02 ADH1A,ADH1B,CETP,FASN,NR3C1,PPAR nuclear receptor A,TPI1,TXNIP

281 XBP1 transcription 4,73E-02 APBB2,BCL2,CRK,DNAJC3,ERLEC1,PHLD regulator A2,S100A6,TFDP1 282 REL transcription 4,86E-02 BCL2,BCL2A1,CXCL8,MMP9,PMAIP1,RE regulator LB,TNFSF13B 283 RELB -0,270 transcription 0,469 4,87E-02 BCL2,CCL19,CCND1,IL1B,RELB,TNF regulator 284 NCOA3 0,218 transcription -1,000 4,87E-02 CCDC80,CCNE1,HMOX1,IGF1,MCM7,N regulator COA3 285 NFYA transcription 4,87E-02 FASN,FTH1,GADD45A,IGF1,LPIN1,PMAI regulator P1 286 TLR7 transmembrane 1,855 4,93E-02 BCL2,CXCL1,CXCL3,CXCL8,FGF2,GNG2,I receptor L1B,IRAK4,MYD88,PLAU,PTX3,TNF 287 PAF1 other 1,265 4,98E-02 CITED2,DDX58,IFI44,IFIT3,OAS2,OASL,P LAUR,SDC4,SERPINE1,ULBP2 288 ERG transcription 2,400 5,44E-02 CLIP1,CXCL1,DOCK10,DOCK2,DYNC1I1, regulator EPB41L3,FYN,GMFB,LAMA5,MAGI1,MY O5A,PHACTR2,PLAUR,PTPN11,RAB2A,R AB7A,RASIP1,RGS3,SIRT5,SLIT2,SVIL,TRI OBP,TSC22D3,WASF3,WNT11

289 MAPK1 0,140 kinase -2,899 5,45E-02 ADAM12,BCL2,C1S,CTSB,DDX58,ERAP1, FN1,GLS,H2AFV,IFI44,IFI6,IFIT1,IFIT2,IFI T3,IFIT5,ITGAV,MECP2,MVP,OAS1,OAS 2,OASL,PLA2G4A,PLD1,PPT2,SAMHD1,S ETD2,STAT1,TNF,TRIM22,UBE2I 290 SRC (family) group 2,200 5,97E-02 CD36,CDKN1C,ITGAV,STAT1,TNF

291 Pkc(s) group -2,054 6,19E-02 BCL2,CXCL8,FGF2,JUN,JUNB,NQO1,PPA RA,SP1,ULBP2 292 CD28 transmembrane -2,083 6,76E-02 CCL4,CCNE1,CD69,CDKN1B,CXCL8,EGR receptor 2,FYN,IL10,ORAI3,PDE4B,PHB2,RNF128 ,SP1,TFRC,TNF,TNFAIP3 293 S100A6 0,184 transporter -2,646 7,04E-02 CXCL8,EXOSC8,PCDHB2,SELE,STC1,TNF AIP3,TPM4 294 IL2 cytokine 1,987 7,27E-02 AHR,BCL2,CD69,CDKN2C,EPHA4,GADD 45G,IL10,IL1B,LCP2,PDE4B,PRDM1,STK 17B,TNF 295 Fcer1 complex 2,400 7,37E-02 CCL4,CXCL8,IFIT2,IL1B,IL1RN,TNF 296 TGFB1 growth factor 2,538 7,37E-02 AKR1C1/AKR1C2,ANGPTL4,CCND2,CCR 10,CD163,CDC42SE1,CDKN1B,CDKN2B, CDKN2C,CITED2,COL3A1,CSF1R,CXCL8, FAS,FBN1,FGF2,FN1,FOXO1,HEXB,HMO X1,IGF1,IRS1,ITGAV,ITGB2,JUN,JUNB,K DM5B,LASP1,MAPK1,MMP9,NEDD9,NE T1,PDGFA,PDLIM4,PLAU,PLAUR,RAB31, RAD51C,RHOB,S100A4,SERPINE1,SPAR C,TGFBR2,TIMP1,TNF,TNFRSF12A,TYM P,VASP,VEGFA

297 Akt group 2,138 8,21E-02 BCL2A1,CCND1,CD274,COL3A1,CXCL8, MMP9,PEA15,PMAIP1,TNF 298 SIN3A -0,185 transcription 2,000 8,85E-02 BCL6,CCNG2,GADD45B,LHCGR,MMP9,T regulator XNIP 299 TLR2 transmembrane 1,891 9,62E-02 CCR1,CCR5,CD69,CXCL8,IL10,IL15,IL1B, receptor MMP9,SIN3A,TNF 300 IRF3 transcription 2,401 9,70E-02 CCL19,CXCL8,IFI6,IFIT1,IFIT2,MMP9,TN regulator F 301 UHRF2 enzyme -2,449 1,05E-01 CCNE1,CKB,FHDC1,FOXO1,FOXO3,SIVA 1 302 MMP2 peptidase 2,236 1,12E-01 CCND1,CSF2RB,IL1RN,PPP2R1A,SOCS1

303 PPARD ligand-dependent -1,948 1,12E-01 ANGPTL4,CCNE1,CEBPB,PTEN,VEGFA nuclear receptor

304 SPHK1 kinase 1,967 1,18E-01 CXCL8,IL1B,SERPINE1,TNF 305 EP300 transcription 1,756 1,20E-01 CCND1,CCNE1,CCNG2,CHKA,CXCL8,IGF regulator 1,ITGB2,MGMT,PLA2G4A,SIRT1,TNF 306 EZH2 transcription 2,610 1,31E-01 ADRB2,ALOX5AP,CCND1,CCND2,CDKN2 regulator B,CXCL1,CXCL8,FHOD3,FUCA1,HOXB6, MAL2,NCOA7,NLK,PLA2G4A,S100A4,SI RT1,TNF 307 26s complex -1,959 1,56E-01 CXCL8,DDX58,JUNB,MDM4,PTEN Proteasome

308 TXN 0,279 enzyme -1,960 1,56E-01 BCL2,C5,IL1B,TXN,VEGFA 309 BCR complex 2,122 1,63E-01 BCL2A1,BCL6,CCL4,CCND2,CD69,JUNB, (complex) MIR155HG,PRDM1,ZBTB16 310 NFkB complex 2,714 1,64E-01 BCL2,BCL2A1,CCL4,CCND1,CEBPB,CLU, (complex) CSNK2A1,CXCL1,CXCL3,CXCL8,ERAP1,E RAP2,FAS,FTH1,FUCA1,HMOX1,IL10RA, IL15,IL1B,JUNB,MMP9,NCF2,PLAU,PPA RA,RELB,SDC4,SOCS1,STAT5A,TNF,TNF AIP3,TNFSF4,TPMT,TWIST1

311 CUL4B other 2,000 1,72E-01 DARS,EIF3I,TPI1,UBXN1 312 IL1 group 1,980 1,72E-01 CXCL8,IL10,MMP9,TNFRSF11B 313 miR-22-3p mature microrna 2,213 1,81E-01 AGBL5,ARRB1,BIN1,FBXO46,FRAT2 (miRNAs w/seed AGCUGCC) 314 CAMP other 2,295 2,06E-01 CCL4,CXCL1,CXCL8,IL10,IL1B,TNF 315 KDM5B -0,257 transcription -2,273 2,31E-01 ASF1A,CAV1,CCND1,CYB5A,ECT2,FJX1, regulator GADD45A,HSD17B8,ITGB1BP1,LIMCH1, NEDD9,PLS3,PSD3,RECQL,RNASET2,SW AP70,TUBB2A 316 PI3K complex 1,946 2,35E-01 CCL4,CCND1,CXCL8,IFIT1,IL1B,LASP1,N (complex) QO1,PRDM1,PTPN12,TNF,VEGFA 317 CHUK 0,159 kinase 1,964 2,65E-01 CCND1,CHUK,CXCL8,PLA2G4A 318 PTGS2 enzyme 1,987 2,71E-01 ANXA1,CXCL8,EGR1,EZR,IL1B,MMP9,R HOA,TNF,VPS72 319 FOXM1 transcription 2,061 2,92E-01 CAV1,CCND1,CDKN1B,CENPB,MMP9,P regulator GK1,PLAUR 320 NCOA1 transcription 1,912 2,92E-01 CCND1,FRAT2,HIRA,MAF1,RFX1,SERPIN regulator E1,STRN 321 SPDEF transcription -2,000 3,31E-01 COL16A1,COL5A2,COL6A1,LASP1,PLAU, regulator PLAUR,PTPRF,SERPINE1,VASP 322 TLR4 transmembrane 2,099 3,39E-01 CXCL8,IL10,IL15,IL1B,IRAK3,MMP9,TNF receptor 323 Interferon group 2,000 3,40E-01 ASCC2,AUTS2,CSF2RB,DDX58,DEFB1,IFI alpha T1,IFIT2,IFIT3,IGFBP4,IL15,IL17RA,MYD 88,OAS1,SPRY1,STAT4,TNF,TRIOBP

324 miR-122-5p mature microrna 2,138 4,13E-01 AACS,ANK2,CCNG1,FOXJ3,MECP2,NFAT (miRNAs C2IP,OSMR,RAB11FIP1 w/seed GGAGUGU) 325 Mek group 1,775 5,04E-01 CCND1,CDKN1B,CXCL8,DDR2,DUSP6,EG R1,EREG,FASN,HRH1,JUN,SERPINE1,SP RY1 326 NANOG transcription -1,897 5,44E-01 CCND2,CNOT7,COL3A1,EGR1,HSPA1A/ regulator HSPA1B,MAP1B,NRIP1,PHACTR2,S100A 6,SRRT,ZFHX3 327 KAT5 transcription 1,913 1,00E00 APEX1,CCND1,CCND2,CXCL8,EREG,GTF regulator 2H5,MNDA,PALMD,RGS1 328 CCND1 0,685 transcription -1,980 1,00E00 BCL2,CCNE1,CDKN1B,CDKN2C,EIF5A2,E regulator NDOD1,ERI1,KLHDC1,KLHL24,MAGI2,M CM7,MFSD6,POLD3,SATB1,SLC9B2,TGF BR2,TM7SF2,TNF,TYMP 329 miR-146a-5p mature microrna -1,982 1,00E00 CHUK,CXCL8,IL10,TNF (and other miRNAs w/seed GAGAACU) Supplementary data S4B Adipose tissue - upstream regulator analysis of the significantly changed transcripts in the heavier compared with their leaner co-twins Upstream Log Ratio Molecule Type Activation p-value Target molecules in dataset Regulator z-score 1 NR3C1 -0,245 ligand- -0,990 1,09E-05 ACAT1,ACTN1,ADCK3,ALOX5AP,ANXA1,AP dependent OE,APTX,ARRB1,ATXN1,BAG3,BAG4,BNIP 3L,BOK,C1QTNF7,CARD10,CARD6,CBX4,C nuclear receptor CL2,CDKN1C,CIDEA,CORO1C,DAG1,DAPK2 ,DAXX,DYNLL1,ELMO2,ENC1,FASTKD1,GL UL,GULP1,HSD11B1,IFIH1,IKBKB,IL15,IL15 RA,IL3RA,ING1,IRF1,LEP,LGALS12,LRRC8A, MAP3K14,MAX,MOAP1,MYD88,NAMPT,N OL3,NR3C1,PEA15,PHLDA2,PLAGL1,PLK2, PPP3R1,PSMG2,RAD21,RHOB,RRAGC,SGP L1,SLC19A2,STAT3,STAT6,TNFAIP2,TNFAIP 3,TNFRSF10A,TNFRSF11B,TNFRSF1A,TNFR SF1B,UBE2K,WDR6,YWHAG,YWHAH

2 miR-219a-5p mature microrna -1,982 1,78E-04 ALOX5,CD14,PLCG2,TNFRSF1B (and other miRNAs w/seed GAUUGUC)

3 BACH1 transcription -2,390 2,48E-04 CALM1 (includes regulator others),FTH1,GCLM,HMOX1,NQO1,SQST M1,TFE3 4 MYOC other 2,97E-04 ANXA1,CA2,CARD10,CHRDL1,DAB2,GPRAS P1,HSPA5,JDP2,KCNJ2,NBN,NOL3,PGR,PH LDA2,PTGER4,RGS17,SESN2,STC2,UPP1

5 CEBPA transcription 0,426 3,62E-04 ACSL1,ALOX5AP,ANXA1,C3AR1,CA2,CSF1 regulator R,CXCR4,DYNLT3,GJA1,H1FX,HMOX1,ID2, ITGAL,ITGB5,LYL1,NFIL3,PFN2,PTPN3,RAB 31,RNF144A,SECTM1,SERPINB1,SERPINI1 ,TBXAS1,TUBB2A,VCL

6 IL13 cytokine -1,588 3,97E-04 AVPI1,C3AR1,CCL18,CCL2,CCL26,CD14,CD 163,CHCHD7,CISH,CTNNAL1,CXCR4,CYBB, DUSP10,DYNLT3,F13A1,FADS1,FAM162A, FEZ1,FGD2,FLOT1,HSD11B1,HTRA1,IFFO1, IL13RA1,IL3RA,IRAK3,LILRB2,LTA4H,MAF, MS4A4A,PAPSS1,PCM1,PDGFC,PFKP,PPAR G,ST3GAL6

7 SREBF1 transcription 4,81E-04 ACACA,CAPZB,DARS,GRSF1,HMOX1,HSPA regulator 1A/HSPA1B,HSPA5,IRS2,LPIN1,MLYCD,O AT,PCK2,SORBS3,TF 8 FSH complex -1,353 8,79E-04 ACTN1,ADCY7,BNIP3L,CARD10,CDK14,CD KN1C,CREBZF,CXCR4,DAB2,DHRS3,DNAJB 9,DUSP3,ENC1,EZR,GATA6,HBP1,HSD11B1 ,IGFBP3,ING1,INHBB,ITGB5,ITPR1,LHCGR, MAP2K1,MAP3K5,NOL3,PCK1,PLIN3,POP5 ,PPAP2A,PPP3R1,PSMD1,PTP4A1,RAB1A, RAB27A,RAB2A,RAB31,RHOB,SMAD5,SM ARCA4,STK17A,STK24,TNFAIP3,TNFRSF11 B,UPP1,VCL,VEGFA,ZNF331

9 MGEA5 -0,259 enzyme 0,156 1,11E-03 ACSS2,APOBEC3G,AZGP1,CAV1,CCND1,CC NG2,CMTM8,CREB3L2,DAB2,FDFT1,FERM T2,FGFR1OP,FLNA,GLI3,GLUL,GPT2,HSF2,I FNGR2,IGBP1,ITGB5,JDP2,LPHN2,LSS,MAP 3K3,NSDHL,PDCD2,PDK1,PECR,PPAP2B,PR F1,RAB27A,RAP2A,RASA3,RHOB,RPS6KA3, TFDP1,TGDS,TNC,TPD52L1,TRADD,WNT11

10 Lh complex -1,519 1,16E-03 ACTN1,ADCY7,BNIP3L,CARD10,CDK14,CD KN1C,CXCR4,DAB2,DHRS3,DUSP3,EZR,GJA 1,HSD11B1,INHBB,ITGB5,ITPR1,LHCGR,M AP2K1,MAP3K5,NOL3,PLIN3,POP5,PPAP2 A,PPP3R1,PSMD1,PTP4A1,RAB1A,RAB27A ,RAB2A,RAB31,RHOB,SMARCA4,STK17A,S TK24,TNFAIP3,TNFRSF11B,UPP1,VCL,VEGF A 11 PRKCA kinase 0,000 1,63E-03 APOBEC3G,ARHGDIB,ARPC2,CCL2,HS2ST1 ,HSPA1A/HSPA1B,MRPL9,NQO1,PHLDA2, PLD1,RHOBTB3,TRPC1,VEGFA

12 ELAVL1 other 1,63E-03 ARG2,CALM1 (includes others),FLNA,GNB2L1,HMOX1,NDUFB8,PL CG2,QARS,RFC5,RPN2,RPS14,RPS6,STAT3, TAF9,TIMM17A 13 ERG transcription 1,342 1,72E-03 ARHGAP17,CDC42BPB,CHTOP,COLGALT1, regulator CXCR4,DOCK10,DOCK2,DSTN,DYNC1I1,EP B41L3,EXT1,GMFB,HPCAL1,LAMA5,MAGI 1,MYO5A,NLGN1,PCNP,POU2F1,PPAP2B, PTPN4,RAB2A,RAB7A,RASSF1,RGS3,SVIL, WNT11 14 NPC2 other -0,832 1,85E-03 AKR1C3,PLA2G4A,PPARG,PTGER4,PTGES,S TAT2,STAT3 15 APOE -0,783 transporter 2,25E-03 CALU,DDT,HDLBP,ITM2B,LEP,MAPK3,SIRT 1,SLC25A6 16 mir-27 microrna 0,815 3,12E-03 IGF1,PPARA,PSAP,SP3,SPRY2,ZBTB10 17 TP73 transcription -0,411 3,57E-03 ABCC1,ADAM17,ARNTL,AUH,CCNG2,CDK regulator N1B,CLMN,COX4I1,CTH,DBP,DHRS3,DRA M1,FGF2,FKBP1B,FXR1,IL4R,MIR22HG,PIG F,PLK2,PTPN3,TNFRSF1B,TWIST1,VEGFA,Y WHAB 18 MAPK9 kinase 0,137 3,66E-03 ACACA,CAV1,CCL2,CDKN1B,IRF9,LPL,MET AP2,NR1H3,NR3C2,PARP14,PLA2G4A,PPA RG,PTEN 19 miR-122-5p mature microrna -1,796 4,40E-03 AACS,ADAM17,ANK2,CCNG1,EEF1A1,ENT (miRNAs PD4,GALNT10,NUMBL,OSMR,PSME3,RAB 6B,RABIF,XPO6 w/seed GGAGUGU) 20 KRAS enzyme 0,707 4,58E-03 CCND1,CDKN1B,DUSP4,EEF1A1,FTH1,MX2 ,NRAS,PLD1,RPS6,TNFRSF10A,UPP1 21 PHB2 -0,147 transcription 0,277 5,20E-03 CDKN1C,PGR,SOCS5,STAT3,TXN regulator 22 miR-26a-5p mature microrna 5,63E-03 GSK3B,PGR,PTEN (and other miRNAs w/seed UCAAGUA) 23 FSTL3 other 5,63E-03 ACVR1,CDKN1B,FST 24 APEX1 -0,121 enzyme 5,63E-03 ALOX5,SIRT1,VEGFA 25 EPAS1 transcription -1,231 6,11E-03 C1QA,CAV1,CHKA,CKB,CORO1A,GJA1,GLS, regulator IGFBP3,INHBB,IRS2,ITIH5,ITPR1,PFKFB3,SL C6A8,STC2,TAF9B,VEGFA 26 INS other -0,365 6,81E-03 ACACA,CIDEA,COX4I1,CUL5,INSR,LPL,NR1 H3,PPARG,VEGFA 27 TP53 transcription 3,161 7,70E-03 ABCC1,ADRB2,ADRBK2,AK1,ANXA1,APOE, regulator ARL6IP1,ATG4A,BNIP3,C12orf5,CAV1,CCN B1IP1,CCNG1,CDKN1B,CERS6,CLU,CSTF1, DBP,DRAM1,DUSP4,EGFL6,FDFT1,FKBP1B, GSK3B,HMOX1,HRAS,HSPA1A/HSPA1B,HT T,ID2,IGF1,IGFBP3,IRS1,LPIN1,LSS,MAP2K 1,MAP4,MAPK3,MCM3,MCM6,MGST2,M OCOS,MRPL46,MSH6,MYBL1,NOX4,PDK1, PERP,PFKFB3,PFKP,PHLDA3,PLK2,PPM1A, PTEN,PTP4A1,PTPN6,PTPRA,PVRL3,RBM3 4,RRM2B,SCO2,SEC62,SESN2,SIRT1,SPATA 18,SRSF3,STK17A,TAGLN2,TNFRSF10A,TN FRSF1B,TPD52L1,TRIM22,TWIST1,VEGFA, YWHAH,ZNF24

28 MTA1 transcription 9,47E-03 ADRB2,CCND1,CDKN1C,GSK3B,RNF144A,S regulator IRT1 29 MMP14 peptidase -0,447 1,19E-02 ANXA7,NR3C1,SMARCA1,SNRPB2,STK38

30 HMGA1 transcription 0,490 1,25E-02 ATM,CAV1,CCND1,INSR,PPARG,STAT3,XP regulator A 31 AKT1 kinase 2,433 1,28E-02 AKR1C1/AKR1C2,CDKN1B,CIDEA,GCLM,H MOX1,NQO1 32 A2M transporter 0,000 1,28E-02 ATF6,CCND1,EIF2A,GSK3B,HSPA5,MAP3K 5 33 mir-130 microrna 1,29E-02 IRF8,MAFB,PPARA 34 LEPR transmembrane 1,29E-02 IGF1,IGFBP3,LEP receptor 35 NDUFAB1 -0,099 enzyme 1,34E-02 DBT,DLAT 36 DLX4 transcription 1,34E-02 FGF2,VEGFA regulator 37 PIWIL2 other 1,34E-02 CCND1,STAT3 38 HP peptidase 1,34E-02 CD163,HMOX1 39 BRD2 kinase 1,34E-02 HMOX1,NQO1 40 Growth group -0,194 1,38E-02 ADRB2,BMP4,CCND1,CISH,MSTN,NR1D1,P hormone DK4,PFKFB3,PLK2,SOCS2,TXNIP 41 mir-21 microrna 0,493 1,68E-02 IRAK1,MYD88,PPARA,PTEN,STAT3 42 NR1H4 ligand- -1,298 1,78E-02 ACSS1,ADH1A,ADH1B,CETP,NR3C1,PNPLA dependent 3,PPARA,TXNIP nuclear receptor

43 HIC1 transcription -0,302 1,79E-02 ABHD3,ADRB2,CA2,CCND1,CDKN1C,FADS regulator 1,FST,GRSF1,ITPR1,MAP2K5,PLA2G4A,SIR T1,WDR6 44 IGF1 -0,376 growth factor 1,523 1,85E-02 BMP4,CCND1,CDKN1B,IFNGR2,IGF1,IGFBP 3,IRS1,IRS2,ITGAV,ITGB5,SLC20A1,VEGFA

45 PI3K (family) group 2,586 2,13E-02 AKR1C1/AKR1C2,CCL2,CCNG2,CXCR4,FOX O4,GCLM,HMOX1,HSPA5,LEP,NQO1,TXNI P,VEGFA 46 ESRRA ligand- -1,131 2,17E-02 ACADM,ATP5B,MINOS1,NDUFA1,NDUFB5 dependent ,NR1D1,PPARGC1A,WNT11 nuclear receptor

47 Hsp27 group 0,447 2,19E-02 CCND1,CD14,CD163,CSF1R,NOX4,STAT3

48 miR-124-3p mature microrna 0,555 2,28E-02 ATP6V0E1,ELOVL5,GAS2L1,NR3C2,SUCLG (and other 2 miRNAs w/seed AAGGCAC) 49 MBD3 other 2,28E-02 APOE,BCAT2,COX6C,PTPN4,SIRT1 50 Cg complex -1,209 2,33E-02 CCL2,FST,GATA6,IGFBP3,ITGAV,ITGB5,LHC GR,MAF,MARCH3,NPR3,NRIP1,PFKFB3,PKI A,PPAP2B,SLC20A1,SPRY2,UPP1,VEGFA

51 NDUFA13 enzyme 2,35E-02 CCND1,CTTN,TFDP1 52 BTRC enzyme 2,35E-02 CCND1,DEPTOR,PHLPP1 53 PRKCZ kinase 2,35E-02 LHCGR,PHGDH,VEGFA 54 HSF2 -0,261 transcription 2,35E-02 CLU,HSPA1A/HSPA1B,TXN regulator 55 MYC transcription 0,066 2,36E-02 ACACA,APEX1,C12orf49,CAV1,CCNG2,CD1 regulator 51,CDKN1B,CDKN2B,CLU,GCLM,GJA1,GLS, HNRNPA1,HSPH1,ID2,IQGAP2,MTHFD1,N BN,ODC1,PDK1,PERP,RRM2B,SCPEP1,SH MT1,TNFRSF10A,TXNIP,USP54,VEGFA,YTH DC1 56 HIF1A transcription -0,771 2,39E-02 APOE,ARPC2,ATG9A,BNIP3L,CAV1,CCND1, regulator CCNT1,CHKA,CORO1A,CXCR4,GJA1,IGF1,I GFBP3,INHBB,IRS2,ITPR1,LEP,NOX4,PDK1, PFKFB3,PPARA,SESN2,STC2,TAF9B,TMEM 19,VASP,VEGFA,ZDHHC9

57 PPARGC1A -0,908 transcription -0,342 2,48E-02 ACADM,C12orf5,COX4I1,GSK3B,PCK2,SCO regulator 2,SESN2 58 CHI3L1 enzyme 2,78E-02 AKAP11,CALD1,NAMPT,SERPINB1,TNC,VE GFA 59 SYVN1 transporter 3,128 2,89E-02 CALM1 (includes others),CCND1,CD151,CEP164,CRTAP,CYB 561,DAB2,DAG1,HLA- A,IFITM2,IRAK2,ITGAV,MYOF,NDFIP2,NUD T21,PPAP2B,PTBP1,PTPRJ,PTRF,RPN2,SLC 20A1,SLC39A10,SLC43A2 60 IL5 cytokine 1,320 3,01E-02 ATXN1,CCL2,CSF2RB,FCGR2B,GCLM,HSPH 1,IL3RA,NACA,UPP1,ZNF25 61 ITGB1 transmembrane 0,970 3,02E-02 ABCC1,CCL2,CDKN1B,FLNA,ITGAV,PTGER4 receptor ,VEGFA 62 SELPLG 0,217 other 1,890 3,63E-02 BST1,CCL2,CXCR4,HCK,IGF1,IL4R,STAT6

63 Actin group 3,70E-02 ABCC1,FLNA 64 c-Src group 3,70E-02 ASAH1,HMOX1 65 WHSC1 enzyme 3,70E-02 BACE2,CA2 66 CIAO1 transcription 3,70E-02 FAM96B,MMS19 regulator 67 miR-103-3p mature microrna 3,70E-02 GRN,RPS6 (and other miRNAs w/seed GCAGCAU) 68 CLTC other 3,70E-02 CD74,RRM2B 69 mir-24 microrna 3,70E-02 PSAP,SPRY2 70 GRN 0,253 growth factor 3,70E-02 CCND1,GRN 71 SSTR2 -0,031 g-protein 3,70E-02 TNFRSF10A,TNFRSF1A coupled receptor

72 ARF1 enzyme 3,70E-02 CCND1,MCM6 73 KLF13 transcription 3,70E-02 KLF9,PGR regulator 74 PITX1 transcription 3,70E-02 CCND1,FST regulator 75 NRIP1 -0,491 transcription 3,77E-02 CCND1,CCNG2,PGR regulator 76 KDM5A transcription 1,131 4,11E-02 CCND1,CDKN1B,HMOX1,MCM3 regulator 77 Ctbp group 4,11E-02 ADRB2,CCND1,RAB29,SIRT1 78 MECP2 transcription 4,23E-02 ADAM12,APOE,BCAT2,IGFBP3,MGMT,RAS regulator SF1 79 MYCN transcription 4,23E-02 ABCC1,APEX1,CDKN1B,ID2,NBN,PDK1 regulator 80 SPI1 transcription 4,75E-02 C1QC,CSF2RB,CYBB,FCGRT,FTH1,IRF9,NCF regulator 4,PTPN6,VAV1 81 AMPK complex -1,949 5,41E-02 PDHB,PFKFB3,PPARGC1A,VEGFA 82 ZNF217 transcription 1,890 5,60E-02 ARMCX5,CCL2,IGFBP3,MAP2K5,NLGN1,N regulator MNAT2,PKP2,RAB22A,SEMA3A,SOCS2,ST3 GAL6,ST6GAL1,ZHX2 83 TGM2 enzyme 4,035 5,93E-02 ACSS2,BNIP3,CA2,CCL2,CCND1,CD74,CX3C R1,DAPK2,DDX60L,EPB41L4A- AS1,GIMAP2,GJA1,HIP1,IL10RA,IRF9,LILRB 2,MAFB,ORC3,PARP14,PARP9,PLEKHO2,P TGES,SLC27A2,SWT1,TNFAIP2,TNIP1,TOR 1B,TRIM22,UBXN8,VSIG4

84 CD24 other -3,162 1,04E-01 ADRB2,CAV1,CTTN,FXR1,HOMER3,HS2ST1 ,HSPB8,IRAK1BP1,LAT2,LRPPRC,MTUS1,N RIP1,PTP4A1,RAD50,TMEM135,TRIM2

85 CUL4B other 2,000 1,04E-01 CCNH,DARS,NDUFB1,UBXN1 86 CSF2 cytokine 1,811 1,63E-01 ATXN1,CCL18,CCL2,CSF2RB,CYBB,FCGR2B, GCLM,HSPH1,IL3RA,NACA,UPP1,ZNF25

87 MAPK1 kinase -2,055 1,67E-01 ADAM12,ADAM17,ADAR,DEPTOR,GLS,IFI H1,IFITM1,IRF9,ITGAV,MMP28,MNS1,MX 2,PHF11,PLA2G4A,PLD1,SECTM1,SETD2,S PRY2,STAT2,TRIM22,TRIM25,TRIM38,TRP C1 88 TFEB transcription 2,000 1,94E-01 ATP6V0E1,GNS,MCOLN1,PSAP regulator 89 Notch group 1,981 1,95E-01 CCL19,CDKN2B,ID2,S100A11,TAGLN 90 IFNB1 cytokine 2,200 2,62E-01 FGF2,IFIH1,IRF1,IRF9,STAT2 91 KITLG growth factor 1,964 2,72E-01 ALOX5,ALOX5AP,CCL2,CDKN1B 92 IFNG cytokine 2,406 3,02E-01 AIF1,AUTS2,C1QA,C1QB,C1QC,CCL18,CCL 2,CD163,CISH,CXCR4,CYBB,DRG1,ERAP2,F GF2,HDAC9,HLA- A,HSPA1A/HSPA1B,HTRA1,IFIH1,IL15,IRF1 ,IRF8,IRF9,ITGAV,LARGE,MED15,MX2,MY D88,NLRC5,PTGES,SOCS2,ST13,STAT2,TNF RSF1A,TNFRSF1B,TRIM22

93 TNF cytokine 1,811 3,06E-01 ALDH1A3,APOE,BTG3,C10orf10,CCL18,CC L2,CCND1,CD163,CXCR4,CYBB,DUSP10,EX T1,FST,GCLM,HDAC9,HMOX1,IL15,IL4R,IR AK3,IRF1,ITGAL,ITGAV,LSS,LTBP2,MCM3, NQO1,NR1H3,OSMR,PHGDH,PPAP2A,PPA RA,PPARG,PPARGC1A,PPP1R3C,PTGES,RA NBP9,RBPMS,ROBO1,RXRA,SCO2,SERPINB 1,SLC16A5,SQSTM1,STAC,SYNPO,TNC,TNF AIP2,TNFAIP3,TNFRSF11B,TNFRSF1B,VCL, VEGFA

94 HR transcription -2,000 3,26E-01 CSNK2A2,GPD1L,MAGI2,NACC2 regulator 95 IFNA2 cytokine 1,957 3,32E-01 C19orf66,CISH,CYB5A,FGF2,IFIH1,IFITM1,I RF1,IRF9,LILRB2,SOCS2,TNFRSF1A

96 AR ligand- -2,138 3,40E-01 AKR1C3,AZGP1,CAST,CAV1,CDK14,EPB41L dependent 4B,HSPH1,IGF1,IGFBP3,LRRK1,PGR,RHOB, TPD52L1,VEGFA nuclear receptor

97 FOXO1 transcription -1,935 3,69E-01 CCNG2,CDKN1B,CDKN1C,CDKN2B,IRS2,LE regulator MD3,PCK1,PPARGC1A,TXNIP 98 EHF transcription 2,121 4,27E-01 ALOX5,BLNK,BMP4,CDKN1B,HMOX1,TNC, regulator VEGFA,VNN1 99 SOCS1 other -1,980 4,36E-01 CCND1,IFIH1,IRF1,STAT6 100 IL1RN cytokine -2,121 5,18E-01 ERAP2,HDAC9,IFIH1,IRF1,IRF9,MX2,STAT2 ,TRIM22 101 IFNL1 cytokine 2,449 1,00E00 C19orf66,IFIH1,IFITM1,IRF9,PHF11,TRIM2 2 102 TGFB1 growth factor 2,299 1,00E00 AKR1C1/AKR1C2,ALOX5,CCL2,CD163,CDK N1B,CDKN2B,CDKN2C,CRIP2,CSF1R,CX3CR 1,CXCR4,FGF2,HMOX1,IGF1,IGFBP3,IRS1,I TGAV,KDM5B,LASP1,LTBP2,LTBP3,MAPK3 ,MYBL1,PTPRK,RAB31,RHOB,SEMA3A,TAG LN,TNC,VASP,VEGFA

103 Akt group 1,982 1,00E00 CCND1,CXCR4,LEP,PEA15 104 estrogen group -1,872 1,00E00 ANXA1,CALD1,CAV1,CCND1,CD99,CLDN23 receptor ,COL12A1,CXCR4,FGF1,HSPA1A/HSPA1B, MAP1B,MSN,NRIP1,PCDH18,PDGFC,PGR,T NC,VEGFA 105 IRF4 transcription -2,216 1,00E00 CX3CR1,IRF1,IRF9,PHF11,STAT2 regulator Supplementary data S5A Adipocytes - significantly differentially expressed and mitochondria-related genes in the heavier compared with their leaner co-twins Numb Gene ID Gene Gene name logFC Average P-value Adjusted p- er symbol Expression value 1 10632 ATP5L ATP synthase, H+ -0,13366 11,0138749 9,25E-06 0,026343795 transporting, mitochondrial Fo complex, subunit G

2 5164 PDK2 pyruvate -0,55101 8,01490757 1,97E-05 0,039350691 dehydrogenase kinase, isozyme 2 3 4714 NDUFB8 NADH -0,16264 8,11215348 4,70E-05 0,048370272 dehydrogenase (ubiquinone) 1 beta subcomplex, 8, 19kDa

4 10840 ALDH1L1 aldehyde -0,70485 8,96719514 5,35E-05 0,052275713 dehydrogenase 1 family, member L1

5 7296 TXNRD1 thioredoxin 0,375113 9,251955 6,45E-05 0,054142161 reductase 1 6 10240 MRPS31 mitochondrial -0,25297 8,93465256 7,37E-05 0,054142161 ribosomal protein S31 7 3033 HADH hydroxyacyl-CoA -0,31528 12,4107012 0,000176885 0,060754677 dehydrogenase 8 124995 MRPL10 mitochondrial -0,25532 9,7662062 0,000156423 0,060754677 ribosomal protein L10 9 51116 MRPS2 mitochondrial -0,40941 7,83118401 0,000197818 0,060866216 ribosomal protein S2 10 10131 TRAP1 TNF receptor- -0,27649 7,63648161 0,000246623 0,062195098 associated protein 1 11 637 BID BH3 interacting 0,286923 6,63456238 0,000279353 0,065864151 domain death agonist 12 1743 DLST dihydrolipoamide S- -0,29085 10,1403984 0,000281657 0,065864151 succinyltransferase (E2 component of 2- oxo-glutarate complex) 13 55168 MRPS18A mitochondrial -0,27856 7,58619431 0,000353569 0,073486547 ribosomal protein S18A 14 79746 ECHDC3 enoyl CoA -0,6323 11,4221493 0,000368486 0,073486547 hydratase domain containing 3

15 26589 MRPL46 mitochondrial -0,21901 8,44114119 0,000396998 0,073912171 ribosomal protein L46 16 586 BCAT1 branched chain 0,699393 4,69409567 0,000408829 0,074205433 amino-acid transaminase 1, cytosolic 17 5827 PXMP2 peroxisomal -0,50613 8,40959995 0,000486385 0,077283878 membrane protein 2, 22kDa 18 32 ACACB acetyl-CoA -0,41404 11,9291796 0,00070422 0,07888426 carboxylase beta 19 1632 ECI1 enoyl-CoA delta -0,48824 8,79984435 0,000784205 0,07888426 isomerase 1 20 2744 GLS glutaminase 0,461048 7,49942997 0,000621697 0,07888426 21 4329 ALDH6A1 aldehyde -0,54283 9,70888247 0,000599339 0,07888426 dehydrogenase 6 family, member A1

22 4711 NDUFB5 NADH -0,22199 12,4016222 0,000769718 0,07888426 dehydrogenase (ubiquinone) 1 beta subcomplex, 5, 16kDa

23 4724 NDUFS4 NADH -0,15787 11,2276008 0,000669385 0,07888426 dehydrogenase (ubiquinone) Fe-S protein 4, 18kDa (NADH-coenzyme Q reductase)

24 9588 PRDX6 peroxiredoxin 6 -0,24097 13,5713935 0,000661605 0,07888426 25 11315 PARK7 parkinson protein 7 -0,108 13,4911953 0,000702792 0,07888426

26 11331 PHB2 prohibitin 2 -0,26253 12,0774781 0,0005897 0,07888426 27 25875 LETMD1 LETM1 domain -0,37295 10,1191236 0,000583502 0,07888426 containing 1 28 51205 ACP6 acid phosphatase 6, -0,45151 6,6608661 0,000566871 0,07888426 lysophosphatidic

29 51295 ECSIT ECSIT signalling -0,32922 7,40621752 0,000778317 0,07888426 integrator 30 192286 HIGD2A HIG1 hypoxia -0,26138 10,625345 0,00064914 0,07888426 inducible domain family, member 2A

31 197257 LDHD lactate -0,78837 6,68960447 0,000700185 0,07888426 dehydrogenase D 32 4522 MTHFD1 methylenetetrahydr -0,2951 12,1191744 0,000826238 0,080739933 ofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydr ofolate cyclohydrolase, formyltetrahydrofol ate synthetase 33 4702 NDUFA8 NADH -0,25457 10,1021105 0,000819512 0,080739933 dehydrogenase (ubiquinone) 1 alpha subcomplex, 8, 19kDa

34 4710 NDUFB4 NADH -0,06019 4,66507956 0,000813074 0,080739933 dehydrogenase (ubiquinone) 1 beta subcomplex, 4, 15kDa

35 293 SLC25A6 solute carrier family -0,21279 12,6754912 0,000861689 0,081374337 25 (mitochondrial carrier; adenine nucleotide translocator), member 6

36 1351 COX8A cytochrome c -0,18518 11,9643593 0,000963868 0,0845742 oxidase subunit VIIIA (ubiquitous)

37 2495 FTH1 ferritin, heavy 0,388425 11,9322689 0,000939148 0,0845742 polypeptide 1 38 4357 MPST mercaptopyruvate -0,3422 8,6781278 0,000939268 0,0845742 sulfurtransferase

39 6390 SDHB succinate -0,17551 10,7273403 0,000958207 0,0845742 dehydrogenase complex, subunit B, iron sulfur (Ip) 40 54543 TOMM7 translocase of outer -0,17374 13,3848469 0,000964577 0,0845742 mitochondrial membrane 7 homolog (yeast)

41 84706 GPT2 glutamic pyruvate -0,46694 8,39501442 0,000942628 0,0845742 transaminase (alanine aminotransferase) 2

42 3028 HSD17B10 hydroxysteroid (17- -0,20914 9,54318332 0,001033024 0,085486555 beta) dehydrogenase 10

43 7381 UQCRB ubiquinol- -0,18117 7,61217087 0,001006292 0,085486555 cytochrome c reductase binding protein 44 55335 NIPSNAP3 nipsnap homolog -0,61687 9,03443841 0,001051507 0,085486555 B 3B (C. elegans) 45 56997 ADCK3 aarF domain -0,43347 9,14404416 0,001076018 0,085486555 containing kinase 3

46 1327 COX4I1 cytochrome c -0,17487 13,1152031 0,001201923 0,087631876 oxidase subunit IV isoform 1 47 5264 PHYH phytanoyl-CoA 2- -0,1987 12,1153036 0,001210633 0,087631876 hydroxylase 48 23417 MLYCD malonyl-CoA -0,35145 7,16736739 0,00123252 0,087965061 decarboxylase 49 54948 MRPL16 mitochondrial -0,17112 9,54782507 0,00132771 0,089406036 ribosomal protein L16 50 203427 SLC25A43 solute carrier family 0,307618 9,06046253 0,00132939 0,089406036 25, member 43

51 515 ATP5F1 ATP synthase, H+ -0,12442 12,6741586 0,001351905 0,089564882 transporting, mitochondrial Fo complex, subunit B1 52 6576 SLC25A1 solute carrier family -0,452 10,1119108 0,001413817 0,090893553 25 (mitochondrial carrier; citrate transporter), member 1

53 25828 TXN2 thioredoxin 2 -0,24243 9,0829016 0,001394635 0,090893553 54 8192 CLPP caseinolytic -0,18234 8,39787802 0,001471699 0,092532698 mitochondrial matrix peptidase proteolytic subunit

55 1329 COX5B cytochrome c -0,20474 11,4884088 0,001604697 0,094537687 oxidase subunit Vb

56 670 BPHL biphenyl hydrolase- -0,35142 8,74348427 0,001638695 0,095034578 like (serine hydrolase)

57 92106 OXNAD1 oxidoreductase -0,22722 6,60495185 0,001647628 0,095269921 NAD-binding domain containing 1 58 5091 PC pyruvate -0,49206 9,4145425 0,001759359 0,099445001 carboxylase 59 506 ATP5B ATP synthase, H+ -0,18872 12,4322126 0,001793626 0,099587009 transporting, mitochondrial F1 complex, beta polypeptide 60 18 ABAT 4-aminobutyrate -0,19634 5,76650772 0,001880169 0,099781162 aminotransferase 61 215 ABCD1 ATP-binding -0,36816 6,2174861 0,002017847 0,099781162 cassette, sub-family D (ALD), member 1

62 517 ATP5G2 ATP synthase, H+ -0,25214 11,5044164 0,00201612 0,099781162 transporting, mitochondrial Fo complex, subunit C2 (subunit 9) 63 1537 CYC1 cytochrome c-1 -0,28332 10,5866794 0,00198576 0,099781162 64 7384 UQCRC1 ubiquinol- -0,21833 10,7602972 0,001903283 0,099781162 cytochrome c reductase core protein I 65 7385 UQCRC2 ubiquinol- -0,21326 11,9977721 0,001830535 0,099781162 cytochrome c reductase core protein II 66 1350 COX7C cytochrome c -0,39032 9,627263 0,002162082 0,102661473 oxidase subunit VIIc

67 3735 KARS lysyl-tRNA -0,16465 11,3345192 0,002114 0,102661473 synthetase 68 8673 VAMP8 vesicle-associated 0,612256 8,23914167 0,002158199 0,102661473 membrane protein 8

69 400916 CHCHD10 coiled-coil-helix- -0,43532 10,3051801 0,002129211 0,102661473 coiled-coil-helix domain containing 10 70 593 BCKDHA branched chain -0,3681 7,76357173 0,002188769 0,10293549 keto acid dehydrogenase E1, alpha polypeptide

71 10455 ECI2 enoyl-CoA delta -0,1634 10,6666297 0,00220876 0,10293549 isomerase 2 72 65005 MRPL9 mitochondrial -0,19858 9,09787644 0,002223157 0,102960598 ribosomal protein L9 73 10128 LRPPRC leucine-rich -0,16465 9,43652263 0,002246009 0,103487248 pentatricopeptide repeat containing

74 2581 GALC galactosylceramidas 0,183503 4,98101683 0,002441449 0,106932746 e 75 57205 ATP10D ATPase, class V, 0,48104 6,5207773 0,002470432 0,107335219 type 10D 76 64975 MRPL41 mitochondrial -0,1781 10,4189339 0,002485494 0,107335219 ribosomal protein L41 77 54996 MARC2 mitochondrial -0,20873 9,45470868 0,002510821 0,107849415 amidoxime reducing component 2 78 2108 ETFA electron-transfer- -0,26454 12,360353 0,002541941 0,108249269 flavoprotein, alpha polypeptide

79 3030 HADHA hydroxyacyl-CoA -0,14155 11,0152539 0,002544747 0,108249269 dehydrogenase/3- ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit 80 3418 IDH2 isocitrate -0,338 7,17235379 0,002831654 0,112712509 dehydrogenase 2 (NADP+), mitochondrial 81 38 ACAT1 acetyl-CoA -0,20222 8,84328936 0,002854626 0,112763186 acetyltransferase 1

82 539 ATP5O ATP synthase, H+ -0,10205 13,5997894 0,003005144 0,115372112 transporting, mitochondrial F1 complex, O subunit

83 6470 SHMT1 serine -0,39079 9,83364337 0,00305897 0,115372112 hydroxymethyltrans ferase 1 (soluble)

84 51081 MRPS7 mitochondrial -0,18571 8,86427422 0,003080533 0,115372112 ribosomal protein S7 85 122961 ISCA2 iron-sulfur cluster -0,18911 8,22968778 0,00304921 0,115372112 assembly 2

86 56474 CTPS2 CTP synthase 2 -0,16007 6,435547 0,003157403 0,115600877 87 64960 MRPS15 mitochondrial -0,19716 11,5239539 0,003261161 0,116710584 ribosomal protein S15 88 78988 MRPL57 mitochondrial -0,14662 9,03533221 0,003378972 0,118313588 ribosomal protein L57 89 27109 ATP5S ATP synthase, H+ -0,16005 7,52962102 0,003561803 0,120356557 transporting, mitochondrial Fo complex, subunit s (factor B) 90 509 ATP5C1 ATP synthase, H+ -0,14504 12,1617555 0,003904848 0,125727099 transporting, mitochondrial F1 complex, gamma polypeptide 1 91 9377 COX5A cytochrome c -0,15089 12,7865029 0,003986608 0,126781365 oxidase subunit Va

92 10884 MRPS30 mitochondrial -0,21209 7,9967907 0,004016963 0,127034835 ribosomal protein S30 93 92609 TIMM50 translocase of inner -0,16794 8,79344127 0,004070631 0,127698906 mitochondrial membrane 50 homolog (S. cerevisiae)

94 10105 PPIF peptidylprolyl -0,29021 9,60583696 0,004117906 0,128450937 isomerase F 95 51253 MRPL37 mitochondrial -0,18393 9,50525889 0,004288126 0,129913771 ribosomal protein L37 96 7923 HSD17B8 hydroxysteroid (17- -0,33772 7,37177646 0,004425622 0,131109041 beta) dehydrogenase 8 97 10440 TIMM17A translocase of inner 0,18948 9,30952723 0,004429404 0,131109041 mitochondrial membrane 17 homolog A (yeast)

98 64969 MRPS5 mitochondrial -0,16668 7,56423817 0,004409937 0,131109041 ribosomal protein S5 99 55037 PTCD3 pentatricopeptide -0,13101 6,45330262 0,004591077 0,133325436 repeat domain 3

100 64757 MARC1 mitochondrial -0,26816 12,0426956 0,004696615 0,13572035 amidoxime reducing component 1 101 27440 CECR5 cat eye syndrome -0,18709 7,60285802 0,004818464 0,137678461 chromosome region, candidate 5

102 55967 NDUFA12 NADH -0,10196 11,9262646 0,004811834 0,137678461 dehydrogenase (ubiquinone) 1 alpha subcomplex, 12 103 54704 PDP1 pyruvate 0,25814 6,557361 0,004834267 0,137727281 dehyrogenase phosphatase catalytic subunit 1

104 587 BCAT2 branched chain -0,39708 6,20205569 0,004958849 0,139046988 amino-acid transaminase 2, mitochondrial 105 91689 SMDT1 single-pass -0,17426 10,2272046 0,004952927 0,139046988 membrane protein with aspartate-rich tail 1

106 65993 MRPS34 mitochondrial -0,17084 8,4300616 0,005115845 0,14211427 ribosomal protein S34 107 3420 IDH3B isocitrate -0,18961 9,16113026 0,005185325 0,142540181 dehydrogenase 3 (NAD+) beta 108 57176 VARS2 valyl-tRNA -0,28521 7,60368187 0,00543847 0,145934001 synthetase 2, mitochondrial 109 2639 GCDH glutaryl-CoA -0,35633 7,37441417 0,005620603 0,149302347 dehydrogenase 110 4722 NDUFS3 NADH -0,19635 9,53953731 0,005676865 0,149325227 dehydrogenase (ubiquinone) Fe-S protein 3, 30kDa (NADH-coenzyme Q reductase)

111 64976 MRPL40 mitochondrial -0,17719 9,94787212 0,005980176 0,152198358 ribosomal protein L40 112 4706 NDUFAB1 NADH -0,12823 12,4986964 0,006007298 0,152476136 dehydrogenase (ubiquinone) 1, alpha/beta subcomplex, 1, 8kDa 113 4720 NDUFS2 NADH -0,13552 10,7120365 0,006092129 0,152939917 dehydrogenase (ubiquinone) Fe-S protein 2, 49kDa (NADH-coenzyme Q reductase)

114 26073 POLDIP2 polymerase (DNA- -0,13884 8,43499831 0,006237544 0,153753087 directed), delta interacting protein 2 115 84311 MRPL45 mitochondrial -0,15862 8,33950608 0,006263916 0,153753087 ribosomal protein L45 116 8816 DCAF5 DDB1 and CUL4 -0,12047 7,81955432 0,006622948 0,158045053 associated factor 5

117 56945 MRPS22 mitochondrial -0,19976 9,37514284 0,006663414 0,158230352 ribosomal protein S22 118 118980 SFXN2 sideroflexin 2 -0,38029 4,7386336 0,006702471 0,158230352 119 11019 LIAS lipoic acid -0,29567 7,04469987 0,006930882 0,161065618 synthetase 120 414919 C8orf82 chromosome 8 -0,37584 7,40388446 0,007296977 0,164099435 open reading frame 82 121 31 ACACA acetyl-CoA -0,49915 10,344271 0,007481223 0,164958225 carboxylase alpha

122 2230 FDX1 ferredoxin 1 0,140657 8,12603411 0,00748559 0,164958225 123 4594 MUT methylmalonyl CoA -0,18559 10,0776062 0,007470125 0,164958225 mutase 124 116228 COX20 COX20 cytochrome 0,202947 8,88333954 0,00778836 0,168399109 C oxidase assembly factor

125 622 BDH1 3-hydroxybutyrate -0,64706 3,14211879 0,00802712 0,169702824 dehydrogenase, type 1

126 2631 GBAS glioblastoma -0,19978 12,3601184 0,008069885 0,169702824 amplified sequence

127 2879 GPX4 glutathione -0,13499 14,5631763 0,008083783 0,169702824 peroxidase 4 128 8165 AKAP1 A kinase (PRKA) -0,25047 8,25504788 0,00824209 0,171183219 anchor protein 1 129 29796 UQCR10 ubiquinol- -0,1597 8,29662691 0,008694379 0,175721769 cytochrome c reductase, complex III subunit X

130 1891 ECH1 enoyl CoA -0,15651 12,9250322 0,00884584 0,176953024 hydratase 1, peroxisomal 131 137872 ADHFE1 alcohol -0,40967 8,22505194 0,008916011 0,177810729 dehydrogenase, iron containing, 1 132 8801 SUCLG2 succinate-CoA -0,19225 11,2873135 0,00903059 0,178276622 ligase, GDP- forming, beta subunit 133 4191 MDH2 malate -0,20747 10,4983543 0,009173032 0,179098647 dehydrogenase 2, NAD (mitochondrial) 134 35 ACADS acyl-CoA -0,25036 8,9334812 0,009247289 0,179387398 dehydrogenase, C-2 to C-3 short chain

135 27247 NFU1 NFU1 iron-sulfur -0,15171 11,6617421 0,009265862 0,179387398 cluster scaffold homolog (S. cerevisiae) 136 10201 NME6 NME/NM23 -0,41079 6,3744027 0,009405281 0,180496598 nucleoside diphosphate kinase 6 137 253512 SLC25A30 solute carrier family 0,082788 2,50019573 0,009767761 0,183655627 25, member 30

138 51409 HEMK1 HemK -0,12691 5,78312129 0,009972335 0,184913969 methyltransferase family member 1

139 55735 DNAJC11 DnaJ (Hsp40) -0,16167 6,41907635 0,010071139 0,185569526 homolog, subfamily C, member 11

140 154791 C7orf55 chromosome 7 -0,24432 8,60375052 0,010112031 0,186091838 open reading frame 55 141 51073 MRPL4 mitochondrial -0,21503 7,08379521 0,010140382 0,186256227 ribosomal protein L4 142 84681 HINT2 histidine triad -0,2434 10,1585478 0,010275143 0,187329662 nucleotide binding protein 2 143 64978 MRPL38 mitochondrial -0,29301 7,05695286 0,010573702 0,189272992 ribosomal protein L38 144 5018 OXA1L oxidase -0,22597 10,5208435 0,010670282 0,189972363 (cytochrome c) assembly 1-like 145 4716 NDUFB10 NADH -0,19367 11,4538265 0,010747212 0,190277186 dehydrogenase (ubiquinone) 1 beta subcomplex, 10, 22kDa

146 138428 PTRH1 peptidyl-tRNA -0,16809 4,75434424 0,01091902 0,191735247 hydrolase 1 homolog (S. cerevisiae) 147 4695 NDUFA2 NADH -0,09669 10,6178737 0,010992547 0,192317102 dehydrogenase (ubiquinone) 1 alpha subcomplex, 2, 8kDa

148 10157 AASS aminoadipate- -0,51094 7,25650166 0,010973386 0,192317102 semialdehyde synthase 149 51020 HDDC2 HD domain -0,16814 8,41863255 0,011031708 0,192615277 containing 2 150 1345 COX6C cytochrome c -0,11986 13,3651962 0,011381212 0,194547417 oxidase subunit VIc

151 57546 PDP2 pyruvate -0,27871 7,33063114 0,01143698 0,194547417 dehyrogenase phosphatase catalytic subunit 2

152 55260 TMEM143 transmembrane -0,21616 5,2427266 0,011529685 0,194759 protein 143 153 80273 GRPEL1 GrpE-like 1, -0,15773 8,64449472 0,011872991 0,197485728 mitochondrial (E. coli) 154 498 ATP5A1 ATP synthase, H+ -0,07897 13,9721414 0,012175349 0,199125544 transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle 155 123096 SLC25A29 solute carrier family -0,11306 3,00303977 0,012336603 0,199446716 25 (mitochondrial carnitine/acylcarniti ne carrier), member 29

156 8604 SLC25A12 solute carrier family 0,173665 6,87830058 0,012378425 0,199772038 25 (aspartate/glutamat e carrier), member 12 157 51650 MRPS33 mitochondrial -0,18676 9,57749405 0,012791191 0,20292887 ribosomal protein S33 158 57380 MRS2 MRS2 magnesium -0,14698 8,93581918 0,012815147 0,2030732 transporter 159 4715 NDUFB9 NADH -0,15111 11,6092114 0,013235703 0,206929369 dehydrogenase (ubiquinone) 1 beta subcomplex, 9, 22kDa

160 8402 SLC25A11 solute carrier family -0,17472 7,77134616 0,013299501 0,207111904 25 (mitochondrial carrier; oxoglutarate carrier), member 11 161 201626 PDE12 phosphodiesterase 0,143416 8,37495959 0,01341905 0,208641142 12 162 4700 NDUFA6 NADH -0,12592 9,62128136 0,013563238 0,209611346 dehydrogenase (ubiquinone) 1 alpha subcomplex, 6, 14kDa

163 114789 SLC25A25 solute carrier family -0,27492 10,5425783 0,013567251 0,209611346 25 (mitochondrial carrier; phosphate carrier), member 25

164 1892 ECHS1 enoyl CoA -0,22202 12,5127127 0,013769906 0,211571582 hydratase, short chain, 1, mitochondrial 165 4694 NDUFA1 NADH -0,07711 12,266274 0,014115506 0,21452056 dehydrogenase (ubiquinone) 1 alpha subcomplex, 1, 7.5kDa

166 11067 C10orf10 chromosome 10 -0,44804 12,3272548 0,014194017 0,215044853 open reading frame 10 167 54675 CRLS1 cardiolipin synthase -0,17258 9,36462371 0,01429254 0,215499801 1 168 84987 COX14 cytochrome c -0,23482 10,7611719 0,014420007 0,216466774 oxidase assembly homolog 14 (S. cerevisiae) 169 25961 NUDT13 nudix (nucleoside 0,206511 3,96448932 0,014484021 0,217082593 diphosphate linked moiety X)-type motif 13

170 7295 TXN thioredoxin 0,278599 12,4554887 0,014616719 0,217238898 171 7284 TUFM Tu translation -0,12795 5,51314961 0,014641183 0,217272043 elongation factor, mitochondrial

172 9512 PMPCB peptidase -0,07735 5,98450513 0,014641059 0,217272043 (mitochondrial processing) beta 173 9804 TOMM20 translocase of outer -0,10414 12,4065891 0,014680378 0,217523353 mitochondrial membrane 20 homolog (yeast)

174 64087 MCCC2 methylcrotonoyl- -0,21317 8,8693081 0,014730089 0,217798155 CoA carboxylase 2 (beta) 175 1352 COX10 cytochrome c -0,23519 6,75489823 0,014752012 0,217923906 oxidase assembly homolog 10 (yeast)

176 23474 ETHE1 ethylmalonic -0,33125 7,26642489 0,014847699 0,218188905 encephalopathy 1

177 119559 SFXN4 sideroflexin 4 -0,27624 7,46123393 0,014839829 0,218188905 178 5096 PCCB propionyl CoA -0,31677 9,3569639 0,015375607 0,221909938 carboxylase, beta polypeptide 179 4701 NDUFA7 NADH -0,10984 7,7732906 0,015551303 0,223153205 dehydrogenase (ubiquinone) 1 alpha subcomplex, 7, 14.5kDa

180 55526 DHTKD1 dehydrogenase E1 -0,24639 7,95055483 0,016185692 0,226924795 and transketolase domain containing 1

181 2647 BLOC1S1 biogenesis of -0,33629 9,14387482 0,016413541 0,22896948 lysosomal organelles complex- 1, subunit 1

182 8802 SUCLG1 succinate-CoA -0,14539 12,4487 0,016483757 0,229294342 ligase, alpha subunit 183 6208 RPS14 ribosomal protein -0,17863 13,7615252 0,016667775 0,230390027 S14 184 55312 RFK riboflavin kinase 0,157516 7,89203095 0,01697333 0,231749628 185 6834 SURF1 surfeit 1 -0,18235 10,5654974 0,017573315 0,236467152 186 51762 RAB8B RAB8B, member 0,241439 7,68591823 0,017596833 0,236467152 RAS oncogene family 187 30968 STOML2 stomatin (EPB72)- -0,17385 8,67901596 0,017805191 0,238182518 like 2 188 2194 FASN fatty acid synthase -0,53991 7,3132982 0,01802364 0,239311607 189 54927 CHCHD3 coiled-coil-helix- -0,11705 10,2770948 0,017974952 0,239311607 coiled-coil-helix domain containing 3 190 57017 COQ9 coenzyme Q9 -0,18509 8,84526671 0,018049744 0,239311607 191 92170 MTG1 mitochondrial -0,20359 4,99394885 0,018048777 0,239311607 ribosome- associated GTPase 1 192 90550 MCU mitochondrial 0,114309 7,70988 0,018111671 0,239333667 calcium uniporter 193 292 SLC25A5 solute carrier family -0,11085 12,3522158 0,018631633 0,24308186 25 (mitochondrial carrier; adenine nucleotide translocator), member 5

194 56267 CCBL2 cysteine conjugate- -0,1931 9,8255517 0,018715683 0,243852875 beta lyase 2

195 29083 GTPBP8 GTP-binding protein -0,09816 7,93406477 0,018872275 0,244913506 8 (putative)

196 4817 NIT1 nitrilase 1 -0,18093 8,01467354 0,019319556 0,246758637 197 51312 SLC25A37 solute carrier family 0,134099 6,87469123 0,019766992 0,249564662 25 (mitochondrial iron transporter), member 37

198 6472 SHMT2 serine -0,11552 6,39368206 0,019852924 0,250326163 hydroxymethyltrans ferase 2 (mitochondrial) 199 55005 RMND1 required for meiotic -0,17335 8,78833393 0,019884491 0,25056254 nuclear division 1 homolog (S. cerevisiae)

200 4731 NDUFV3 NADH -0,19598 8,32245915 0,020087763 0,252148517 dehydrogenase (ubiquinone) flavoprotein 3, 10kDa 201 51251 NT5C3A 5'-nucleotidase, -0,1048 9,04270564 0,020266888 0,253258354 cytosolic IIIA 202 26355 FAM162A family with -0,13615 11,7017747 0,020777898 0,256365687 sequence similarity 162, member A 203 521 ATP5I ATP synthase, H+ -0,15202 11,5050592 0,020929402 0,257403173 transporting, mitochondrial Fo complex, subunit E

204 2926 GRSF1 G-rich RNA -0,10681 8,76331282 0,021028111 0,257825221 sequence binding factor 1 205 57506 MAVS mitochondrial -0,20351 7,41369409 0,021434721 0,260104573 antiviral signaling protein 206 81894 SLC25A28 solute carrier family -0,04617 4,90720513 0,021446465 0,260104573 25 (mitochondrial iron transporter), member 28

207 117145 THEM4 thioesterase -0,16131 8,21747784 0,021940928 0,262753371 superfamily member 4 208 594 BCKDHB branched chain -0,2591 7,86158597 0,021967997 0,262834941 keto acid dehydrogenase E1, beta polypeptide

209 7818 DAP3 death associated -0,10667 11,2644649 0,022016836 0,263017755 protein 3 210 6832 SUPV3L1 suppressor of var1, -0,2034 7,62831344 0,022033902 0,263060836 3-like 1 (S. cerevisiae) 211 219927 MRPL21 mitochondrial -0,18936 8,95689506 0,022135139 0,263304413 ribosomal protein L21 212 92399 MRRF mitochondrial 0,237453 3,52219205 0,02244028 0,264998695 ribosome recycling factor 213 54539 NDUFB11 NADH -0,17562 11,2106264 0,022529332 0,265654783 dehydrogenase (ubiquinone) 1 beta subcomplex, 11, 17.3kDa

214 27429 HTRA2 HtrA serine -0,13821 7,79005124 0,023064018 0,268471212 peptidase 2 215 10981 RAB32 RAB32, member 0,228948 8,26093292 0,023659812 0,272901737 RAS oncogene family 216 128387 TATDN3 TatD DNase domain -0,16368 7,26331669 0,023886172 0,274122932 containing 3

217 2710 GK glycerol kinase 0,517862 3,65748496 0,023947076 0,274223574 218 55178 RNMTL1 RNA -0,19385 7,46830352 0,023981945 0,274255783 methyltransferase like 1 219 28973 MRPS18B mitochondrial -0,14102 8,9661294 0,024431 0,276521377 ribosomal protein S18B 220 8209 C21orf33 chromosome 21 -0,18116 9,03485657 0,024536648 0,276597026 open reading frame 33 221 7263 TST thiosulfate -0,19979 10,9206964 0,025040855 0,27968794 sulfurtransferase (rhodanese) 222 64965 MRPS9 mitochondrial -0,20192 7,74457054 0,025048463 0,27968794 ribosomal protein S9 223 51004 COQ6 coenzyme Q6 -0,27617 6,11543956 0,025415716 0,281909627 monooxygenase 224 740 MRPL49 mitochondrial -0,19014 8,9848685 0,025611639 0,28340232 ribosomal protein L49 225 92259 MRPS36 mitochondrial -0,20755 9,40283328 0,026358507 0,288761576 ribosomal protein S36 226 8766 RAB11A RAB11A, member 0,068222 10,1345258 0,026550714 0,289730406 RAS oncogene family 227 10922 FASTK Fas-activated -0,19387 5,88613026 0,026924477 0,291853561 serine/threonine kinase 228 374291 NDUFS7 NADH -0,19013 9,35209357 0,026968506 0,292168782 dehydrogenase (ubiquinone) Fe-S protein 7, 20kDa (NADH-coenzyme Q reductase)

229 7084 TK2 thymidine kinase 2, 0,165869 8,29452405 0,027397803 0,29469602 mitochondrial 230 10247 HRSP12 heat-responsive -0,18893 10,514792 0,027649764 0,295956889 protein 12 231 5052 PRDX1 peroxiredoxin 1 0,092454 11,8122072 0,028022154 0,297131603 232 80146 UXS1 UDP-glucuronate 0,189419 8,37710437 0,028015803 0,297131603 decarboxylase 1 233 9093 DNAJA3 DnaJ (Hsp40) -0,16022 7,99063956 0,028218334 0,297143924 homolog, subfamily A, member 3 234 60491 NIF3L1 NIF3 NGG1 0,11039 8,00527892 0,028161063 0,297143924 interacting factor 3- like 1 (S. cerevisiae)

235 79568 C2orf47 chromosome 2 -0,12075 9,60711592 0,028433292 0,297794276 open reading frame 47 236 79594 MUL1 mitochondrial E3 -0,20727 6,18153563 0,029329319 0,30184106 ubiquitin protein ligase 1 237 9553 MRPL33 mitochondrial -0,09247 10,9223198 0,029568614 0,301927378 ribosomal protein L33 238 10531 PITRM1 pitrilysin -0,1069 8,92491621 0,030370407 0,305225718 metallopeptidase 1

239 217 ALDH2 aldehyde -0,08935 14,5656002 0,030517296 0,305516756 dehydrogenase 2 family (mitochondrial) 240 55186 SLC25A36 solute carrier family -0,08222 9,59448343 0,03096227 0,308109273 25 (pyrimidine nucleotide carrier ), member 36

241 596 BCL2 B-cell -0,11566 6,86337455 0,031147066 0,308745892 CLL/lymphoma 2 242 10352 WARS2 tryptophanyl tRNA -0,21998 6,73506596 0,031655261 0,31103782 synthetase 2, mitochondrial 243 27034 ACAD8 acyl-CoA -0,21136 8,22033977 0,03179011 0,31103782 dehydrogenase family, member 8 244 5250 SLC25A3 solute carrier family -0,08154 13,546657 0,032148467 0,312144645 25 (mitochondrial carrier; phosphate carrier), member 3

245 23203 PMPCA peptidase -0,14205 7,26343018 0,032536382 0,314427845 (mitochondrial processing) alpha 246 51263 MRPL30 mitochondrial -0,15045 7,83203732 0,032820522 0,316294023 ribosomal protein L30 247 10245 TIMM17B translocase of inner -0,09929 6,49873095 0,033718458 0,320522149 mitochondrial membrane 17 homolog B (yeast)

248 3032 HADHB hydroxyacyl-CoA -0,10779 12,8521402 0,035505776 0,329265842 dehydrogenase/3- ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), beta subunit 249 51142 CHCHD2 coiled-coil-helix- -0,10838 11,9210767 0,035836969 0,331784809 coiled-coil-helix domain containing 2 250 1347 COX7A2 cytochrome c -0,0977 13,0241126 0,036022726 0,333031297 oxidase subunit VIIa polypeptide 2 (liver)

251 384 ARG2 arginase 2 -0,18269 4,26747868 0,036218367 0,33359465 252 2617 GARS glycyl-tRNA 0,167471 10,2274881 0,037002758 0,336051074 synthetase 253 4898 NRD1 nardilysin (N- -0,11176 10,7588601 0,037582508 0,338641093 arginine dibasic convertase) 254 64756 ATPAF1 ATP synthase -0,20932 11,1888879 0,037872623 0,340388824 mitochondrial F1 complex assembly factor 1 255 79751 SLC25A22 solute carrier family -0,11787 5,75469203 0,037925906 0,340479519 25 (mitochondrial carrier: glutamate), member 22

256 54148 MRPL39 mitochondrial -0,12876 8,8456103 0,039168745 0,34553911 ribosomal protein L39 257 4718 NDUFC2 NADH -0,04862 7,93455405 0,039763021 0,346777543 dehydrogenase (ubiquinone) 1, subcomplex unknown, 2, 14.5kDa 258 84334 APOPT1 apoptogenic 1, -0,13817 8,81377278 0,039895404 0,347109775 mitochondrial 259 23408 SIRT5 sirtuin 5 -0,08796 4,10712656 0,040618663 0,349875051 260 55486 PARL presenilin -0,1328 9,59175755 0,040566175 0,349875051 associated, rhomboid-like 261 10295 BCKDK branched chain -0,18171 6,42245391 0,040733348 0,350310988 ketoacid dehydrogenase kinase 262 51023 MRPS18C mitochondrial -0,04435 2,23679371 0,041555217 0,353607613 ribosomal protein S18C 263 157378 TMEM65 transmembrane 0,216508 6,13172165 0,041980616 0,35518145 protein 65 264 3421 IDH3G isocitrate -0,1298 8,4075553 0,042390649 0,3566435 dehydrogenase 3 (NAD+) gamma 265 56922 MCCC1 methylcrotonoyl- -0,26907 9,93522827 0,042612797 0,358050092 CoA carboxylase 1 (alpha) 266 51011 FAHD2A fumarylacetoacetat -0,13922 6,73203951 0,042684258 0,358188549 e hydrolase domain containing 2A

267 387 RHOA ras homolog family 0,161928 13,1835689 0,043294233 0,359708932 member A 268 23095 KIF1B kinesin family 0,155909 8,57792351 0,04335294 0,359708932 member 1B 269 84277 DNAJC30 DnaJ (Hsp40) -0,17377 7,08075978 0,043440677 0,359747712 homolog, subfamily C, member 30

270 4697 NDUFA4 NADH -0,13338 12,103135 0,044558992 0,364372886 dehydrogenase (ubiquinone) 1 alpha subcomplex, 4, 9kDa

271 1340 COX6B1 cytochrome c -0,09389 12,5454299 0,044819639 0,365285667 oxidase subunit VIb polypeptide 1 (ubiquitous) 272 11112 HIBADH 3- -0,15162 11,2099054 0,04491259 0,365476657 hydroxyisobutyrate dehydrogenase

273 3155 HMGCL 3-hydroxymethyl-3- -0,12409 9,0707688 0,045512668 0,366896339 methylglutaryl-CoA lyase 274 1723 DHODH dihydroorotate -0,16033 3,72989614 0,047532366 0,374554113 dehydrogenase (quinone) 275 65080 MRPL44 mitochondrial -0,11203 7,76776773 0,048113561 0,376584475 ribosomal protein L44 276 3396 ICT1 immature colon -0,15799 8,6704593 0,048615829 0,379149146 carcinoma transcript 1 277 51027 BOLA1 bolA family -0,12607 6,99378848 0,04863523 0,379149154 member 1 278 116541 MRPL54 mitochondrial -0,13347 9,25769667 0,049386568 0,382110487 ribosomal protein L54 Supplementary data S5B Adipose tissue - significantly differentially expressed and mitochondria-related genes in the heavier compared with their leaner co-twins Numb Gene ID Gene Gene name logFC Average P-value Adjusted p- er symbol Expression value 1 1632 ECI1 enoyl-CoA delta -0,5284 8,74919269 2,57E-05 0,058721202 isomerase 1 2 51020 HDDC2 HD domain containing 2 -0,14488 8,486747213 2,77E-05 0,058721202

3 7296 TXNRD1 thioredoxin reductase 1 0,50588 8,924182598 3,47E-05 0,058721202

4 64965 MRPS9 mitochondrial ribosomal -0,19494 8,016970679 4,72E-05 0,062424851 protein S9 5 8801 SUCLG2 succinate-CoA ligase, GDP- -0,28557 10,99599204 8,58E-05 0,073946546 forming, beta subunit

6 91689 SMDT1 single-pass membrane -0,15062 10,50434097 9,29E-05 0,073946546 protein with aspartate- rich tail 1 7 92259 MRPS36 mitochondrial ribosomal -0,24297 9,589582431 0,000113 0,073946546 protein S36 8 60488 MRPS35 mitochondrial ribosomal -0,13662 8,898478479 0,000129 0,073946546 protein S35 9 197257 LDHD lactate dehydrogenase D -0,84579 5,417009687 0,000132 0,073946546

10 4722 NDUFS3 NADH dehydrogenase -0,1693 9,60735617 0,000152 0,074051502 (ubiquinone) Fe-S protein 3, 30kDa (NADH- coenzyme Q reductase)

11 10128 LRPPRC leucine-rich -0,20502 9,528037204 0,000174 0,074102682 pentatricopeptide repeat containing 12 56945 MRPS22 mitochondrial ribosomal -0,19848 9,363014247 0,000182 0,074102682 protein S22 13 56267 CCBL2 cysteine conjugate-beta -0,24102 10,11001329 0,000193 0,074102682 lyase 2 14 10632 ATP5L ATP synthase, H+ -0,16264 11,01471765 0,000221 0,079844875 transporting, mitochondrial Fo complex, subunit G 15 1329 COX5B cytochrome c oxidase -0,16118 11,83128013 0,000317 0,084354391 subunit Vb 16 1327 COX4I1 cytochrome c oxidase -0,1209 13,09250783 0,000322 0,084354391 subunit IV isoform 1 17 4528 MTIF2 mitochondrial -0,14764 10,19689666 0,00037 0,08775397 translational initiation factor 2 18 4724 NDUFS4 NADH dehydrogenase -0,18445 10,5786819 0,00041 0,089548113 (ubiquinone) Fe-S protein 4, 18kDa (NADH- coenzyme Q reductase)

19 54543 TOMM7 translocase of outer -0,18581 13,62156517 0,000433 0,089548113 mitochondrial membrane 7 homolog (yeast)

20 54675 CRLS1 cardiolipin synthase 1 -0,2536 9,186616971 0,000501 0,089548113 21 3033 HADH hydroxyacyl-CoA -0,34496 12,06675726 0,000624 0,097602426 dehydrogenase 22 54931 TRMT10C tRNA methyltransferase -0,19516 8,492663612 0,000672 0,100822276 10 homolog C (S. cerevisiae)

23 10352 WARS2 tryptophanyl tRNA -0,28151 6,135051229 0,000676 0,100822276 synthetase 2, mitochondrial 24 10240 MRPS31 mitochondrial ribosomal -0,22068 8,926944097 0,000733 0,10455829 protein S31 25 203427 SLC25A43 solute carrier family 25, 0,31399 8,900820241 0,000721 0,10455829 member 43 26 55335 NIPSNAP3 nipsnap homolog 3B (C. -0,74002 8,756056118 0,000761 0,1065189 B elegans) 27 5264 PHYH phytanoyl-CoA 2- -0,2324 12,03387666 0,000917 0,113433534 hydroxylase 28 2495 FTH1 ferritin, heavy 0,42517 11,94299569 0,000998 0,117513091 polypeptide 1 29 4594 MUT methylmalonyl CoA -0,23627 10,26335852 0,001071 0,120630643 mutase 30 3396 ICT1 immature colon -0,17456 8,91591136 0,001109 0,120630643 carcinoma transcript 1 31 5827 PXMP2 peroxisomal membrane -0,55196 8,342976837 0,00113 0,120630643 protein 2, 22kDa

32 6208 RPS14 ribosomal protein S14 -0,20353 13,98841123 0,001139 0,120630643 33 293 SLC25A6 solute carrier family 25 -0,17187 12,39246048 0,00126 0,122064335 (mitochondrial carrier; adenine nucleotide translocator), member 6

34 10939 AFG3L2 AFG3-like AAA ATPase 2 -0,19781 9,198614286 0,001274 0,122064335

35 84311 MRPL45 mitochondrial ribosomal -0,16118 8,079540583 0,00136 0,124225487 protein L45 36 4711 NDUFB5 NADH dehydrogenase -0,23389 12,40355822 0,001363 0,124225487 (ubiquinone) 1 beta subcomplex, 5, 16kDa 37 55288 RHOT1 ras homolog family -0,18979 10,67551949 0,001393 0,124225487 member T1 38 64969 MRPS5 mitochondrial ribosomal -0,11317 7,859536477 0,001746 0,133294576 protein S5 39 26520 TIMM9 translocase of inner -0,20168 9,388711547 0,00182 0,134706651 mitochondrial membrane 9 homolog (yeast)

40 119559 SFXN4 sideroflexin 4 -0,22748 7,564752145 0,001899 0,135577492 41 10884 MRPS30 mitochondrial ribosomal -0,18418 7,28476247 0,001931 0,136417621 protein S30 42 5091 PC pyruvate carboxylase -0,45576 9,107480938 0,002023 0,137727005 43 26589 MRPL46 mitochondrial ribosomal -0,23609 8,448053609 0,002086 0,140603527 protein L46 44 3030 HADHA hydroxyacyl-CoA -0,20752 10,37046781 0,002101 0,141084299 dehydrogenase/3- ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit

45 25875 LETMD1 LETM1 domain -0,30568 10,07002347 0,002122 0,142010058 containing 1 46 51116 MRPS2 mitochondrial ribosomal -0,35205 7,634605474 0,002174 0,144511652 protein S2 47 521 ATP5I ATP synthase, H+ -0,13434 12,28579227 0,002298 0,146460679 transporting, mitochondrial Fo complex, subunit E 48 84134 TOMM40 translocase of outer 0,33652 7,65558446 0,002331 0,14790353 L mitochondrial membrane 40 homolog (yeast)-like

49 2108 ETFA electron-transfer- -0,33655 12,22128071 0,002356 0,148116356 flavoprotein, alpha polypeptide 50 55168 MRPS18A mitochondrial ribosomal -0,16657 7,488608889 0,002404 0,149270602 protein S18A

51 4357 MPST mercaptopyruvate -0,24211 8,271766005 0,002468 0,151232995 sulfurtransferase 52 31 ACACA acetyl-CoA carboxylase -0,54945 9,547711548 0,002488 0,151945241 alpha 53 28973 MRPS18B mitochondrial ribosomal -0,15404 8,965238661 0,002577 0,153035598 protein S18B

54 51650 MRPS33 mitochondrial ribosomal -0,22605 9,515280726 0,002593 0,153035598 protein S33 55 114789 SLC25A25 solute carrier family 25 -0,58156 6,25986189 0,0026 0,153035598 (mitochondrial carrier; phosphate carrier), member 25 56 79145 CHCHD7 coiled-coil-helix-coiled- -0,16734 8,23194477 0,002657 0,154097888 coil-helix domain containing 7 57 5163 PDK1 pyruvate dehydrogenase -0,30436 4,304061759 0,002837 0,156201228 kinase, isozyme 1

58 51277 DNAJC27 DnaJ (Hsp40) homolog, -0,18859 4,534371521 0,002915 0,157001917 subfamily C, member 27

59 5096 PCCB propionyl CoA -0,41329 8,763166493 0,002945 0,157096897 carboxylase, beta polypeptide 60 2631 GBAS glioblastoma amplified -0,23013 12,17062896 0,002977 0,157107743 sequence 61 10157 AASS aminoadipate- -0,60271 7,40890384 0,003018 0,157788214 semialdehyde synthase

62 3735 KARS lysyl-tRNA synthetase -0,14077 11,30495928 0,003126 0,160605059 63 51110 LACTB2 lactamase, beta 2 -0,31024 9,093845337 0,003131 0,160605059 64 1350 COX7C cytochrome c oxidase -0,32009 9,689307031 0,003165 0,161588734 subunit VIIc 65 1345 COX6C cytochrome c oxidase -0,13614 13,19526273 0,003196 0,161891312 subunit VIc 66 1347 COX7A2 cytochrome c oxidase -0,14829 13,21484955 0,003585 0,16966414 subunit VIIa polypeptide 2 (liver) 67 65080 MRPL44 mitochondrial ribosomal -0,19893 7,727002129 0,003752 0,170429708 protein L44 68 84706 GPT2 glutamic pyruvate -0,55897 7,552093305 0,003789 0,170429708 transaminase (alanine aminotransferase) 2 69 11067 C10orf10 chromosome 10 open -0,84952 9,740781453 0,003836 0,170429708 reading frame 10 70 56997 ADCK3 aarF domain containing -0,30192 8,734265124 0,003875 0,170946767 kinase 3 71 64976 MRPL40 mitochondrial ribosomal -0,13115 10,08951348 0,003961 0,173225321 protein L40 72 51081 MRPS7 mitochondrial ribosomal -0,19372 8,581228435 0,004087 0,174164348 protein S7 73 39 ACAT2 acetyl-CoA -0,38486 8,475609141 0,004093 0,174164348 acetyltransferase 2 74 1743 DLST dihydrolipoamide S- -0,27208 9,99083625 0,004098 0,174164348 succinyltransferase (E2 component of 2-oxo- glutarate complex) 75 1312 COMT catechol-O- 0,18905 7,306339595 0,004391 0,178032912 methyltransferase 76 7923 HSD17B8 hydroxysteroid (17-beta) -0,30689 7,508199499 0,004664 0,181184545 dehydrogenase 8

77 4702 NDUFA8 NADH dehydrogenase -0,20362 10,32523258 0,00492 0,185115161 (ubiquinone) 1 alpha subcomplex, 8, 19kDa 78 1351 COX8A cytochrome c oxidase -0,16849 11,85442677 0,005133 0,188224501 subunit VIIIA (ubiquitous)

79 55074 OXR1 oxidation resistance 1 -0,19043 10,71611585 0,005149 0,188466949 80 9868 TOMM70 translocase of outer -0,10885 9,405194714 0,005194 0,189047665 A mitochondrial membrane 70 homolog A (S. cerevisiae)

81 5164 PDK2 pyruvate dehydrogenase -0,32549 5,687859722 0,00524 0,190098008 kinase, isozyme 2

82 539 ATP5O ATP synthase, H+ -0,11607 13,67288514 0,005243 0,190098008 transporting, mitochondrial F1 complex, O subunit 83 26355 FAM162A family with sequence -0,17259 11,59849736 0,005273 0,190489129 similarity 162, member A

84 7381 UQCRB ubiquinol-cytochrome c -0,16591 7,539987741 0,005382 0,191932696 reductase binding protein

85 38 ACAT1 acetyl-CoA -0,23399 8,941226212 0,005457 0,192614326 acetyltransferase 1 86 6576 SLC25A1 solute carrier family 25 -0,43934 8,626622591 0,005501 0,193024917 (mitochondrial carrier; citrate transporter), member 1

87 118980 SFXN2 sideroflexin 2 -0,23795 5,404696498 0,005598 0,19501224 88 10840 ALDH1L1 aldehyde dehydrogenase -0,54996 8,976136132 0,005911 0,199275765 1 family, member L1

89 4715 NDUFB9 NADH dehydrogenase -0,174 11,41912009 0,005922 0,199275765 (ubiquinone) 1 beta subcomplex, 9, 22kDa 90 11112 HIBADH 3-hydroxyisobutyrate -0,24585 10,55516833 0,005934 0,199275765 dehydrogenase 91 51204 TACO1 translational activator of -0,20355 6,789939615 0,006131 0,202398665 mitochondrially encoded cytochrome c oxidase I 92 517 ATP5G2 ATP synthase, H+ -0,16504 11,44160944 0,006188 0,202926044 transporting, mitochondrial Fo complex, subunit C2 (subunit 9) 93 7385 UQCRC2 ubiquinol-cytochrome c -0,22387 11,77769195 0,006435 0,205074818 reductase core protein II

94 4329 ALDH6A1 aldehyde dehydrogenase -0,53887 9,230960601 0,006498 0,206159245 6 family, member A1

95 4695 NDUFA2 NADH dehydrogenase -0,1149 10,68237794 0,006557 0,207149727 (ubiquinone) 1 alpha subcomplex, 2, 8kDa 96 54539 NDUFB11 NADH dehydrogenase -0,15175 11,13794783 0,006788 0,210088067 (ubiquinone) 1 beta subcomplex, 11, 17.3kDa

97 79746 ECHDC3 enoyl CoA hydratase -0,52776 11,33698541 0,006873 0,210552153 domain containing 3 98 55178 RNMTL1 RNA methyltransferase -0,24676 7,589788815 0,00706 0,213252997 like 1

99 4731 NDUFV3 NADH dehydrogenase -0,16115 7,891647242 0,007213 0,216202842 (ubiquinone) flavoprotein 3, 10kDa 100 23417 MLYCD malonyl-CoA -0,27124 7,1751321 0,007413 0,218515956 decarboxylase 101 84274 COQ5 coenzyme Q5 homolog, -0,15751 9,719109792 0,007618 0,223419402 methyltransferase (S. cerevisiae)

102 64756 ATPAF1 ATP synthase -0,23154 10,81670917 0,007826 0,223419402 mitochondrial F1 complex assembly factor 1 103 81689 ISCA1 iron-sulfur cluster -0,10908 10,60589009 0,007887 0,2234743 assembly 1 104 65005 MRPL9 mitochondrial ribosomal -0,11846 9,524543672 0,007909 0,223576571 protein L9 105 128387 TATDN3 TatD DNase domain -0,16446 7,671377524 0,008018 0,224751932 containing 3 106 5166 PDK4 pyruvate dehydrogenase -0,3669 11,73923515 0,008035 0,224751932 kinase, isozyme 4

107 25828 TXN2 thioredoxin 2 -0,1234 8,999599746 0,008104 0,224751932 108 1537 CYC1 cytochrome c-1 -0,27226 9,729845098 0,008721 0,231132372 109 4714 NDUFB8 NADH dehydrogenase -0,1408 9,169121893 0,008869 0,232932653 (ubiquinone) 1 beta subcomplex, 8, 19kDa 110 7084 TK2 thymidine kinase 2, 0,17235 7,924754818 0,008927 0,232932653 mitochondrial 111 54996 MARC2 mitochondrial amidoxime -0,26016 9,149879036 0,009013 0,233930209 reducing component 2

112 18 ABAT 4-aminobutyrate -0,11143 6,63688418 0,009509 0,235844971 aminotransferase 113 6470 SHMT1 serine -0,41944 8,935399174 0,009583 0,236784697 hydroxymethyltransferas e 1 (soluble) 114 55186 SLC25A36 solute carrier family 25 -0,17751 9,895913311 0,009794 0,239688705 (pyrimidine nucleotide carrier ), member 36

115 549 AUH AU RNA binding -0,2864 9,597005357 0,00991 0,240673227 protein/enoyl-CoA hydratase 116 622 BDH1 3-hydroxybutyrate -0,32964 2,67356709 0,009946 0,240673227 dehydrogenase, type 1

117 594 BCKDHB branched chain keto acid -0,31391 7,420701397 0,010414 0,244617841 dehydrogenase E1, beta polypeptide 118 11331 PHB2 prohibitin 2 -0,1471 11,66506194 0,010587 0,245469486 119 26056 RAB11FIP RAB11 family interacting 0,20236 7,427537886 0,010617 0,245469486 5 protein 5 (class I)

120 414919 C8orf82 chromosome 8 open -0,21637 7,908386283 0,011341 0,249740644 reading frame 82 121 7818 DAP3 death associated protein -0,08965 11,11235235 0,011367 0,249740644 3 122 219927 MRPL21 mitochondrial ribosomal -0,13453 8,767845155 0,012139 0,257071119 protein L21 123 84987 COX14 cytochrome c oxidase -0,27142 10,84469135 0,012204 0,257367825 assembly homolog 14 (S. cerevisiae) 124 10131 TRAP1 TNF receptor-associated -0,17827 7,782909979 0,012454 0,259767296 protein 1 125 84896 ATAD1 ATPase family, AAA -0,15016 8,717917679 0,012614 0,262207847 domain containing 1 126 78988 MRPL57 mitochondrial ribosomal -0,09055 9,39034988 0,01268 0,26239057 protein L57 127 11019 LIAS lipoic acid synthetase -0,33431 7,690467883 0,012817 0,263109879 128 122961 ISCA2 iron-sulfur cluster -0,16095 8,399098131 0,012846 0,263109879 assembly 2 129 65008 MRPL1 mitochondrial ribosomal -0,13465 9,246295906 0,013183 0,266937329 protein L1 130 5095 PCCA propionyl CoA -0,23792 9,27021869 0,013428 0,270553229 carboxylase, alpha polypeptide 131 51218 GLRX5 glutaredoxin 5 0,1037 10,65370397 0,013566 0,271226501 132 1737 DLAT dihydrolipoamide S- -0,34739 9,051445478 0,013611 0,271727841 acetyltransferase 133 3155 HMGCL 3-hydroxymethyl-3- -0,12151 8,792696694 0,014819 0,284497871 methylglutaryl-CoA lyase

134 192286 HIGD2A HIG1 hypoxia inducible -0,1702 10,29811846 0,014897 0,284871368 domain family, member 2A 135 55669 MFN1 mitofusin 1 -0,11244 8,480516249 0,015005 0,285426898 136 51660 MPC1 mitochondrial pyruvate -0,19321 10,76147424 0,015086 0,285790044 carrier 1 137 4700 NDUFA6 NADH dehydrogenase -0,17017 9,869783228 0,015091 0,285790044 (ubiquinone) 1 alpha subcomplex, 6, 14kDa 138 211 ALAS1 aminolevulinate, delta-, 0,26049 9,042189597 0,015327 0,287473301 synthase 1 139 128240 APOA1BP apolipoprotein A-I 0,13002 9,124419706 0,015721 0,289320612 binding protein 140 154791 C7orf55 chromosome 7 open -0,25948 9,017046219 0,016136 0,293912613 reading frame 55 141 57149 LYRM1 LYR motif containing 1 -0,12086 11,11928569 0,017341 0,303142285 142 84545 MRPL43 mitochondrial ribosomal -0,13716 8,49855688 0,017584 0,304938066 protein L43 143 80222 TARS2 threonyl-tRNA synthetase -0,13915 5,37490653 0,018125 0,306956101 2, mitochondrial (putative)

144 57546 PDP2 pyruvate dehyrogenase -0,35224 7,14707531 0,018184 0,307034509 phosphatase catalytic subunit 2

145 593 BCKDHA branched chain keto acid -0,26334 7,209823838 0,018262 0,30744369 dehydrogenase E1, alpha polypeptide 146 2180 ACSL1 acyl-CoA synthetase long- -0,23951 14,17250965 0,018482 0,308207183 chain family member 1

147 27247 NFU1 NFU1 iron-sulfur cluster -0,17446 11,64761385 0,018623 0,308537013 scaffold homolog (S. cerevisiae)

148 384 ARG2 arginase 2 -0,12952 2,34177038 0,018865 0,310092146 149 2617 GARS glycyl-tRNA synthetase 0,22114 10,65275411 0,019066 0,310827824

150 137872 ADHFE1 alcohol dehydrogenase, -0,37852 8,420664898 0,019399 0,313281458 iron containing, 1

151 7295 TXN thioredoxin 0,3469 11,89146128 0,01937 0,313281458 152 10229 COQ7 coenzyme Q7 homolog, -0,06034 5,405747611 0,019665 0,313487213 ubiquinone (yeast)

153 509 ATP5C1 ATP synthase, H+ -0,10387 12,25179281 0,019702 0,313819008 transporting, mitochondrial F1 complex, gamma polypeptide 1 154 9588 PRDX6 peroxiredoxin 6 -0,18992 13,53393417 0,019802 0,314783988 155 2639 GCDH glutaryl-CoA -0,2756 6,66538412 0,0199 0,315176846 dehydrogenase 156 6821 SUOX sulfite oxidase -0,31308 6,342099496 0,020144 0,31621769 157 92106 OXNAD1 oxidoreductase NAD- -0,21481 6,643591045 0,020284 0,317139749 binding domain containing 1 158 10455 ECI2 enoyl-CoA delta -0,18784 10,38463994 0,021656 0,326466715 isomerase 2 159 3420 IDH3B isocitrate dehydrogenase -0,1453 9,123451294 0,022077 0,328259793 3 (NAD+) beta

160 10873 ME3 malic enzyme 3, NADP(+)- -0,13107 8,390782711 0,022249 0,32842495 dependent, mitochondrial 161 9512 PMPCB peptidase (mitochondrial -0,05395 6,888079429 0,022443 0,329458434 processing) beta

162 1629 DBT dihydrolipoamide -0,08162 6,211817295 0,022555 0,330198591 branched chain transacylase E2 163 9673 SLC25A44 solute carrier family 25, 0,09407 7,351355642 0,023431 0,335979409 member 44 164 10845 CLPX caseinolytic -0,13353 9,365883987 0,023744 0,338500964 mitochondrial matrix peptidase chaperone subunit 165 4694 NDUFA1 NADH dehydrogenase -0,1009 11,95962467 0,023824 0,339129345 (ubiquinone) 1 alpha subcomplex, 1, 7.5kDa 166 7263 TST thiosulfate -0,2061 10,72958476 0,023986 0,340300796 sulfurtransferase (rhodanese) 167 84681 HINT2 histidine triad nucleotide -0,14536 10,01900141 0,024011 0,340300796 binding protein 2

168 64087 MCCC2 methylcrotonoyl-CoA -0,19689 7,616712485 0,024185 0,341032162 carboxylase 2 (beta) 169 51205 ACP6 acid phosphatase 6, -0,41651 6,326479959 0,024797 0,343956345 lysophosphatidic 170 201626 PDE12 phosphodiesterase 12 0,11698 7,653034406 0,025363 0,347613066 171 6301 SARS seryl-tRNA synthetase -0,04402 7,88463591 0,025459 0,347696721 172 10440 TIMM17A translocase of inner 0,14939 9,072708425 0,025531 0,347962352 mitochondrial membrane 17 homolog A (yeast)

173 3032 HADHB hydroxyacyl-CoA -0,12554 12,69292423 0,025975 0,351064587 dehydrogenase/3- ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), beta subunit

174 400916 CHCHD10 coiled-coil-helix-coiled- -0,33187 9,549410106 0,02601 0,351064587 coil-helix domain containing 10 175 5162 PDHB pyruvate dehydrogenase -0,16465 10,66107382 0,026713 0,355039602 (lipoamide) beta

176 57017 COQ9 coenzyme Q9 -0,16532 8,59334214 0,027715 0,361333388 177 51300 TIMMDC1 translocase of inner 0,08087 11,63527501 0,028031 0,361333388 mitochondrial membrane domain containing 1

178 6341 SCO1 SCO1 cytochrome c -0,21833 7,978683463 0,028269 0,362145099 oxidase assembly protein

179 64757 MARC1 mitochondrial amidoxime -0,27524 11,83759863 0,028335 0,362145099 reducing component 1

180 34 ACADM acyl-CoA dehydrogenase, -0,28422 11,91328169 0,028408 0,362145099 C-4 to C-12 straight chain

181 55005 RMND1 required for meiotic -0,20897 8,323641716 0,028419 0,362145099 nuclear division 1 homolog (S. cerevisiae)

182 4725 NDUFS5 NADH dehydrogenase -0,10327 12,43557689 0,028543 0,362376794 (ubiquinone) Fe-S protein 5, 15kDa (NADH- coenzyme Q reductase)

183 4522 MTHFD1 methylenetetrahydrofola -0,25216 11,59283935 0,028659 0,362534595 te dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolat e cyclohydrolase, formyltetrahydrofolate synthetase 184 4976 OPA1 optic atrophy 1 -0,11836 8,33872207 0,029348 0,367440928 (autosomal dominant) 185 23659 PLA2G15 phospholipase A2, group 0,34359 5,918983465 0,029793 0,369933159 XV 186 506 ATP5B ATP synthase, H+ -0,19465 12,48935478 0,030654 0,377027464 transporting, mitochondrial F1 complex, beta polypeptide 187 2744 GLS glutaminase 0,22028 6,782608404 0,031662 0,382875012 188 27109 ATP5S ATP synthase, H+ -0,14314 7,274992847 0,033219 0,387242864 transporting, mitochondrial Fo complex, subunit s (factor B) 189 55260 TMEM143 transmembrane protein -0,08751 4,621410552 0,033219 0,387242864 143 190 440574 MINOS1 mitochondrial inner 0,12344 5,779943541 0,033321 0,387629763 membrane organizing system 1 191 27430 MAT2B methionine -0,08125 10,7115467 0,034019 0,389812226 adenosyltransferase II, beta 192 8165 AKAP1 A kinase (PRKA) anchor -0,23836 7,991003425 0,034031 0,389812226 protein 1 193 54927 CHCHD3 coiled-coil-helix-coiled- -0,14754 9,854864153 0,034477 0,392547906 coil-helix domain containing 3 194 4698 NDUFA5 NADH dehydrogenase -0,12844 11,3336285 0,034582 0,392979625 (ubiquinone) 1 alpha subcomplex, 5 195 1468 SLC25A10 solute carrier family 25 -0,25514 6,142231666 0,035302 0,396287191 (mitochondrial carrier; dicarboxylate transporter), member 10

196 124995 MRPL10 mitochondrial ribosomal -0,13941 9,648452942 0,036164 0,400978321 protein L10 197 23410 SIRT3 sirtuin 3 -0,05841 5,138051324 0,036211 0,401196594 198 587 BCAT2 branched chain amino- -0,17685 6,264635771 0,036295 0,40163481 acid transaminase 2, mitochondrial 199 6390 SDHB succinate dehydrogenase -0,17946 10,43243103 0,036551 0,402015215 complex, subunit B, iron sulfur (Ip)

200 54958 TMEM160 transmembrane protein 0,30604 6,90994182 0,036394 0,402015215 160 201 5018 OXA1L oxidase (cytochrome c) -0,19047 9,991264759 0,036903 0,404274017 assembly 1-like 202 2926 GRSF1 G-rich RNA sequence -0,07295 8,71738303 0,036942 0,404482905 binding factor 1 203 64978 MRPL38 mitochondrial ribosomal -0,19361 3,883528107 0,036984 0,404486569 protein L38 204 54148 MRPL39 mitochondrial ribosomal -0,18038 8,082514671 0,03874 0,412831589 protein L39 205 55149 MTPAP mitochondrial poly(A) -0,1318 8,294352522 0,039181 0,414476637 polymerase 206 4706 NDUFAB1 NADH dehydrogenase -0,09888 12,4627397 0,039199 0,414476637 (ubiquinone) 1, alpha/beta subcomplex, 1, 8kDa 207 4710 NDUFB4 NADH dehydrogenase -0,09065 6,061410448 0,039446 0,414476637 (ubiquinone) 1 beta subcomplex, 4, 15kDa 208 84532 ACSS1 acyl-CoA synthetase 0,07904 2,471192379 0,039078 0,414476637 short-chain family member 1 209 84105 PCBD2 pterin-4 alpha- -0,18391 5,391126144 0,040001 0,417394855 carbinolamine dehydratase/dimerizatio n cofactor of hepatocyte nuclear factor 1 alpha (TCF1) 2 210 501 ALDH7A1 aldehyde dehydrogenase -0,13432 7,533929215 0,041954 0,426543867 7 family, member A1

211 5106 PCK2 phosphoenolpyruvate -0,32453 7,880434417 0,042128 0,42704591 carboxykinase 2 (mitochondrial) 212 10651 MTX2 metaxin 2 -0,08881 9,574011722 0,042236 0,427629935 213 670 BPHL biphenyl hydrolase-like -0,24578 9,080107584 0,043778 0,43343348 (serine hydrolase) 214 63875 MRPL17 mitochondrial ribosomal 0,11459 8,780791522 0,044013 0,434441726 protein L17 215 4942 OAT ornithine 0,1359 12,21132087 0,044054 0,43462806 aminotransferase 216 4141 MARS methionyl-tRNA 0,15772 8,887458081 0,044103 0,434890783 synthetase 217 84266 ALKBH7 alkB, alkylation repair -0,07035 7,375542309 0,045075 0,438953823 homolog 7 (E. coli) 218 60491 NIF3L1 NIF3 NGG1 interacting 0,08528 9,244306987 0,046035 0,44310772 factor 3-like 1 (S. cerevisiae) 219 11021 RAB35 RAB35, member RAS 0,04515 2,996589087 0,047188 0,44921258 oncogene family 220 253190 SERHL2 serine hydrolase-like 2 0,3646 2,813059789 0,04802 0,451768198

221 55326 AGPAT5 1-acylglycerol-3- 0,1871 5,701555648 0,048311 0,451906811 phosphate O- acyltransferase 5 222 29088 MRPL15 mitochondrial ribosomal -0,10962 10,2148119 0,048707 0,453743275 protein L15 Supplementary data S6A Adipocytes - upstream regulators of the significantly changed and mitochondria- related transcripts in the heavier compared with their leaner co-twins Upstream Regulator Molecule Type p-value Target molecules in dataset

1 SREBF1 transcription regulator 4,98E-07 ACACA,ACADS,ETHE1,FASN,GR SF1,MLYCD,PMPCA,SUCLG1

2 NUAK1 kinase 7,21E-04 COX6B1,NDUFS4 3 SHC1 kinase 7,46E-04 BCL2,FTH1,TXN 4 miR-30a-3p mature microrna 9,59E-04 KIF1B,MCCC2,RAB8B 5 Pkg group 1,43E-03 BCL2,TXN 6 DOHH enzyme 1,43E-03 PARK7,WARS2 7 LIPE enzyme 1,43E-03 FASN,PC 8 ELAVL1 other 1,93E-03 ARG2,NDUFB8,RPS14,SLC25A1 1,TIMM17A 9 MYC transcription regulator 5,70E-03 ACACA,BCAT1,FASN,GLS,MTHF D1,RHOA,SHMT1,SHMT2

10 PPARGC1A transcription regulator 7,51E-03 COX4I1,FASN,GK

11 CLDN7 other 7,89E-03 GLS,MCU,MRPL40,MRPS15,SL C25A22 12 FABP2 transporter 1,22E-02 ACACB,FASN 13 INS other 1,23E-02 ACACA,COX4I1,FASN 14 ESRRA ligand-dependent 1,23E-02 ATP5B,NDUFA1,NDUFB5 nuclear receptor 15 ARHGEF12 other 1,56E-02 RHOA 16 SCAP other 1,56E-02 FASN 17 CTSD peptidase 1,56E-02 TXN 18 NAPA transporter 1,56E-02 BCL2 19 MYBL1 transcription regulator 1,56E-02 BCL2

20 DYNLT3 other 1,56E-02 BCL2 21 SCO2 other 1,56E-02 COX4I1 22 MAOA enzyme 1,56E-02 BCL2 23 ANGPT2 growth factor 1,56E-02 BCL2 24 TRPV4 ion channel 1,56E-02 RHOA 25 SLC25A10 transporter 1,56E-02 ACACA 26 TPD52 other 1,56E-02 BCL2 27 ATF1 transcription regulator 1,95E-02 BCL2,FTH1

28 PRMT1 enzyme 1,95E-02 ARG2,FTH1 29 MBD3 other 2,23E-02 BCAT2,COX6C 30 MBD2 transcription regulator 2,59E-02 ATP5I,BCAT2,COX6C

31 MICU1 other 3,10E-02 BCL2 32 Vla-4 complex 3,10E-02 BCL2 33 ARTN growth factor 3,10E-02 BCL2 34 SOD1 enzyme 3,10E-02 BCL2 35 miR-183-5p mature microrna 3,10E-02 IDH2 36 miR-185-5p mature microrna 3,10E-02 RHOA 37 NUBP1 other 3,10E-02 FTH1 38 FTL enzyme 3,10E-02 FTH1 39 IL17RB transmembrane 3,10E-02 BCL2 receptor 40 CD74 transmembrane 3,10E-02 BCL2 receptor 41 RAC2 enzyme 3,10E-02 BCL2 42 CANX other 3,10E-02 BCL2 43 WTAP other 3,10E-02 BCL2 44 VCP enzyme 3,10E-02 BCL2 45 CDX1 transcription regulator 3,10E-02 BCL2

46 IREB2 translation regulator 3,10E-02 FTH1 47 NEU2 enzyme 3,10E-02 BCL2 48 NR5A2 ligand-dependent 3,15E-02 BCL2,FASN nuclear receptor 49 NFYA transcription regulator 3,84E-02 FASN,FTH1

50 TXN enzyme 4,20E-02 BCL2,TXN 51 APOE transporter 4,57E-02 COX6B1,SLC25A6 52 MALSU1 other 4,61E-02 COX4I1 53 OSGIN1 growth factor 4,61E-02 BCL2 54 SULF2 enzyme 4,61E-02 BCL2 55 Ap2 alpha group 4,61E-02 BCL2 56 PAK4 kinase 4,61E-02 BCL2 57 HINT1 enzyme 4,61E-02 BCL2 58 NRP2 kinase 4,61E-02 BCL2 59 PIAS3 transcription regulator 4,61E-02 FTH1

60 PINK1 kinase 4,61E-02 BCL2 61 MAD2L1 other 4,61E-02 BCL2 62 SOAT1 enzyme 4,61E-02 FASN 63 TNC other 4,61E-02 RHOA 64 CCNL2 other 4,61E-02 BCL2 65 PRNP other 4,61E-02 BCL2 66 AIFM1 enzyme 4,61E-02 NDUFS7 67 FOSB transcription regulator 4,61E-02 FTH1

68 BAG3 other 4,61E-02 BCL2 69 ABCB7 transporter 4,61E-02 FTH1 70 SSTR2 g-protein coupled 4,61E-02 BCL2 receptor 71 DEFB103A other 4,61E-02 BID 72 ACO1 enzyme 4,61E-02 FTH1 73 LILRB1 transmembrane 4,61E-02 BCL2 receptor Supplementary data S6B Adipose tissue - upstream regulators of the significantly changed and mitochondria- related transcripts in the heavier compared with their leaner co-twins Upstream Regulator Molecule Type p-value Target molecules in dataset 1 ESRRA ligand-dependent nuclear 3,76E-05 ACADM,ATP5B,MINOS1,N receptor DUFA1,NDUFB5 2 NDUFAB1 enzyme 1,55E-04 DBT,DLAT 3 SREBF1 transcription regulator 2,60E-04 ACACA,GRSF1,MLYCD,OA T,PCK2 4 PPARGC1A transcription regulator 4,02E-03 ACADM,COX4I1,PCK2 5 ELAVL1 other 5,54E-03 ARG2,NDUFB8,RPS14,TIM M17A 6 SHC1 kinase 9,41E-03 FTH1,TXN 7 EIF2A translation regulator 1,25E-02 PCK2 8 CTSD peptidase 1,25E-02 TXN 9 ABHD5 enzyme 1,25E-02 PDK4 10 SCO2 other 1,25E-02 COX4I1 11 SLC25A10 transporter 1,25E-02 ACACA 12 PRMT1 enzyme 1,28E-02 ARG2,FTH1 13 MBD2 transcription regulator 1,44E-02 ATP5I,BCAT2,COX6C 14 TRIB3 kinase 1,46E-02 GARS,PCK2 15 MBD3 other 1,46E-02 BCAT2,COX6C 16 SAMM50 other 2,48E-02 MTX2 17 NUBP1 other 2,48E-02 FTH1 18 FTL enzyme 2,48E-02 FTH1 19 IREB2 translation regulator 2,48E-02 FTH1 20 AMFR transmembrane receptor 2,48E-02 MFN1

21 MALSU1 other 3,69E-02 COX4I1 22 NUAK1 kinase 3,69E-02 NDUFS4 23 PPARGC1B transcription regulator 3,69E-02 MINOS1 24 PIAS3 transcription regulator 3,69E-02 FTH1 25 EIF2AK4 kinase 3,69E-02 PCK2 26 FOSB transcription regulator 3,69E-02 FTH1 27 ABCB7 transporter 3,69E-02 FTH1 28 ACO1 enzyme 3,69E-02 FTH1 29 Pkg group 4,90E-02 TXN 30 DOHH enzyme 4,90E-02 WARS2 31 MRPL14 other 4,90E-02 COX4I1 32 FABP4 transporter 4,90E-02 ACAT1 33 LIPE enzyme 4,90E-02 PC 34 NFYC transcription regulator 4,90E-02 FTH1 35 NUBPL other 4,90E-02 NDUFS3 36 SP2 transcription regulator 4,90E-02 MAT2B 37 FOXA1 transcription regulator 4,93E-02 ALDH6A1,GLS,NDUFV3 Supplementary data S7A Adipocytes - Significantly changed and consistently up- or downregulated transcripts in the heavier twins compared with their leaner co-twins in at least 12 out of 14 twin pairs Adipocyte Ensembl Genes Adipocyte Ensembl Genes Downregulated Upregulated Genes Genes 1 ABCB7 ENSG00000131269 ABCC1 ENSG00000103222 2 ABCF1 ENSG00000204574 ACSL5 ENSG00000197142 3 ACACA ENSG00000132142 ACTR3 ENSG00000115091 4 ACACB ENSG00000076555 ADAM12 ENSG00000148848 5 ACP6 ENSG00000162836 ADAP2 ENSG00000184060 6 ACSS2 ENSG00000131069 ADSS ENSG00000035687 7 ACSS3 ENSG00000111058 AHR ENSG00000106546 8 ADCK3 ENSG00000163050 AIF1 ENSG00000204472 9 ADD3 ENSG00000148700 AKAP13 ENSG00000170776 10 ADH1B ENSG00000196616 AKR1C2 ENSG00000151632 11 ADNP2 ENSG00000101544 AKR1C3 ENSG00000196139 12 ADORA1 ENSG00000163485 ALCAM ENSG00000170017 13 ADPRM ENSG00000170222 ALDH1A3 ENSG00000184254 14 ADRB1 ENSG00000043591 ANGPT2 ENSG00000091879 15 ADRB2 ENSG00000169252 ANKDD1A ENSG00000166839 16 ADRB3 ENSG00000188778 ANXA1 ENSG00000135046 17 ADSSL1 ENSG00000185100 ANXA4 ENSG00000196975 18 AGT ENSG00000135744 ANXA5 ENSG00000164111 19 AKAP9 ENSG00000127914 ANXA7 ENSG00000138279 20 ALDH1L1 ENSG00000144908 APOLD1 ENSG00000178878 21 ALDH6A1 ENSG00000119711 ARAP2 ENSG00000047365 22 ALPK3 ENSG00000136383 ARF4 ENSG00000168374 23 ANAPC16 ENSG00000166295 ARFIP1 ENSG00000164144 24 ANG ENSG00000214274 ARPC5 ENSG00000162704 25 ANGPTL4 ENSG00000167772 ASAH1 ENSG00000104763 26 ANKMY2 ENSG00000106524 ASAP2 ENSG00000151693 27 APEX1 ENSG00000100823 ASCC3 ENSG00000112249 28 APMAP ENSG00000101474 ASNS ENSG00000070669 29 APOB ENSG00000084674 ATG12 ENSG00000145782 30 APOE ENSG00000130203 ATL3 ENSG00000184743 31 APOL4 ENSG00000100336 ATP1B1 ENSG00000143153 32 ARFGAP1 ENSG00000101199 ATP2B1 ENSG00000070961 33 ARG2 ENSG00000081181 ATP6V1B2 ENSG00000147416 34 ARHGAP31 ENSG00000031081 ATR ENSG00000175054 35 ARHGEF4 ENSG00000136002 BBX ENSG00000114439 36 ARHGEF7 ENSG00000102606 BCAT1 ENSG00000060982 37 ARPC1A ENSG00000241685 BCL2A1 ENSG00000140379 38 ARRB1 ENSG00000137486 BICC1 ENSG00000122870 39 ASXL1 ENSG00000171456 BID ENSG00000015475 40 ATP5B ENSG00000110955 BLOC1S2 ENSG00000196072 41 ATP5C1 ENSG00000165629 BMP2K ENSG00000138756 42 ATP5F1 ENSG00000116459 BPTF ENSG00000171634 43 ATP5G2 ENSG00000135390 C10orf11 ENSG00000148655 44 ATP5L ENSG00000167283 C12orf4 ENSG00000047621 45 ATP6V0C ENSG00000185883 C12orf5 ENSG00000078237 46 AURKAIP1 ENSG00000175756 C16orf54 ENSG00000185905 47 AVPI1 ENSG00000119986 C1orf162 ENSG00000143110 48 AZGP1 ENSG00000160862 C1QA ENSG00000173372 49 BCKDHA ENSG00000248098 C1QB ENSG00000173369 50 BCL6 ENSG00000113916 C1QC ENSG00000159189 51 BEND5 ENSG00000162373 C20orf194 ENSG00000088854 52 BEX4 ENSG00000102409 C3AR1 ENSG00000171860 53 BIN3 ENSG00000147439 C5AR1 ENSG00000197405 54 BLOC1S1 ENSG00000135441 C5orf28 ENSG00000151881 55 BNIP1 ENSG00000113734 C7orf25 ENSG00000136197 56 BNIP3L ENSG00000104765 C7orf73 ENSG00000243317 57 BOK ENSG00000176720 C8orf76 ENSG00000189376 58 BPHL ENSG00000137274 CALD1 ENSG00000122786 59 BTF3 ENSG00000145741 CALU ENSG00000128595 60 C11orf1 ENSG00000137720 CCL13 ENSG00000181374 61 C11orf31 ENSG00000211450 CCL18 ENSG00000006074 62 C12orf39 ENSG00000134548 CCL2 ENSG00000108691 63 C14orf1 ENSG00000133935 CCL4 ENSG00000129277 64 C14orf166 ENSG00000087302 CCR1 ENSG00000163823 65 C14orf2 ENSG00000156411 CD14 ENSG00000170458 66 C15orf40 ENSG00000169609 CD163 ENSG00000177575 67 C16orf80 ENSG00000070761 CD97 ENSG00000123146 68 C17orf85 ENSG00000074356 CDKN2B ENSG00000147883 69 C18orf21 ENSG00000141428 CEP135 ENSG00000174799 70 C1orf50 ENSG00000164008 CLIP1 ENSG00000130779 71 C1QTNF7 ENSG00000163145 CLU ENSG00000120885 72 C20orf27 ENSG00000101220 CNKSR3 ENSG00000153721 73 C6 ENSG00000039537 CNOT8 ENSG00000155508 74 CA2 ENSG00000104267 COL5A2 ENSG00000204262 75 CA3 ENSG00000164879 COPB1 ENSG00000129083 76 CACYBP ENSG00000116161 CORO1C ENSG00000110880 77 CASQ2 ENSG00000118729 COX20 ENSG00000203667 78 CCDC12 ENSG00000160799 CPD ENSG00000108582 79 CCDC50 ENSG00000152492 CPEB4 ENSG00000113742 80 CCDC59 ENSG00000133773 CPPED1 ENSG00000103381 81 CCDC92 ENSG00000119242 CPVL ENSG00000106066 82 CCNH ENSG00000134480 CRIP1 ENSG00000257341 83 CCR10 ENSG00000184451 CRK ENSG00000167193 84 CCT4 ENSG00000115484 CSF2RB ENSG00000100368 85 CD72 ENSG00000137101 CTSO ENSG00000256043 86 CD81 ENSG00000110651 CTSS ENSG00000163131 87 CDADC1 ENSG00000102543 CTTN ENSG00000085733 88 CDC34 ENSG00000099804 CXCL1 ENSG00000163739 89 CDKN1B ENSG00000111276 CXCL16 ENSG00000161921 90 CDKN1C ENSG00000129757 CXCL2 ENSG00000081041 91 CDKN2C ENSG00000123080 CYBB ENSG00000165168 92 CECR5 ENSG00000069998 CYP2U1 ENSG00000155016 93 CHKA ENSG00000110721 CYTIP ENSG00000115165 94 CHP1 ENSG00000187446 DACT1 ENSG00000165617 95 CIDEA ENSG00000176194 DDX58 ENSG00000107201 96 CIRBP ENSG00000099622 DEGS1 ENSG00000143753 97 CISH ENSG00000114737 DEPTOR ENSG00000155792 98 CKB ENSG00000166165 DIXDC1 ENSG00000150764 99 CLASRP ENSG00000104859 DNAJB4 ENSG00000162616 100 CLPP ENSG00000125656 DNAJB6 ENSG00000105993 101 CNOT2 ENSG00000111596 DOCK10 ENSG00000135905 102 COA5 ENSG00000183513 DOK5 ENSG00000101134 103 COG7 ENSG00000168434 DSEL ENSG00000171451 104 COPZ1 ENSG00000111481 DYRK2 ENSG00000127334 105 COQ9 ENSG00000088682 EDEM3 ENSG00000116406 106 COX4I1 ENSG00000131143 EDNRB ENSG00000136160 107 COX8A ENSG00000176340 EEA1 ENSG00000102189 108 CPAMD8 ENSG00000160111 EED ENSG00000074266 109 CRLS1 ENSG00000088766 EFEMP1 ENSG00000115380 110 CSNK1E ENSG00000213923 EGFL6 ENSG00000198759 111 CSNK2A1 ENSG00000101266 EGR2 ENSG00000122877 112 CSNK2B ENSG00000204435 EIF1AX ENSG00000173674 113 CTDSP2 ENSG00000175215 EIF2AK4 ENSG00000128829 114 CTNNAL1 ENSG00000119326 EIF2S1 ENSG00000134001 115 CWC15 ENSG00000150316 ELF1 ENSG00000120690 116 CYB5A ENSG00000166347 ENAH ENSG00000154380 117 CYC1 ENSG00000179091 ENOX2 ENSG00000165675 118 DAPK2 ENSG00000035664 EPB41L3 ENSG00000082397 119 DCAF5 ENSG00000139990 EPDR1 ENSG00000086289 120 DCTN4 ENSG00000132912 EPHA4 ENSG00000116106 121 DCXR ENSG00000169738 EPS8 ENSG00000151491 122 DDT ENSG00000099977 EPT1 ENSG00000138018 123 DDX54 ENSG00000123064 EREG ENSG00000124882 124 DGAT1 ENSG00000185000 ERLIN1 ENSG00000107566 125 DHRS3 ENSG00000162496 ETS2 ENSG00000157557 126 DHX30 ENSG00000132153 ETV6 ENSG00000139083 127 DHX32 ENSG00000089876 EXOC2 ENSG00000112685 128 DHX36 ENSG00000174953 EXOC6 ENSG00000138190 129 DLST ENSG00000119689 EZR ENSG00000092820 130 DNAJA3 ENSG00000103423 F13A1 ENSG00000124491 131 DNAJB1 ENSG00000132002 F2R ENSG00000181104 132 DNAJC11 ENSG00000007923 FAM102B ENSG00000162636 133 DNAJC19 ENSG00000205981 FAM114A1 ENSG00000197712 134 DNAJC7 ENSG00000168259 FAM114A2 ENSG00000055147 135 DRG1 ENSG00000185721 FAM177A1 ENSG00000151327 136 E4F1 ENSG00000167967 FAM20B ENSG00000116199 137 EAPP ENSG00000129518 FAM219A ENSG00000164970 138 EBF1 ENSG00000164330 FAM26E ENSG00000178033 139 ECE1 ENSG00000117298 FAM69A ENSG00000154511 140 ECHDC2 ENSG00000121310 FAM98A ENSG00000119812 141 ECHDC3 ENSG00000134463 FAT1 ENSG00000083857 142 ECHS1 ENSG00000127884 FAT4 ENSG00000196159 143 ECI1 ENSG00000167969 FBXO45 ENSG00000174013 144 ECI2 ENSG00000198721 FCER1G ENSG00000158869 145 EEF2 ENSG00000167658 FCGR2B ENSG00000072694 146 EGR1 ENSG00000120738 FDX1 ENSG00000137714 147 EIF2B4 ENSG00000115211 FILIP1L ENSG00000168386 148 EIF3H ENSG00000147677 FKBP14 ENSG00000106080 149 EIF3K ENSG00000178982 FOLR2 ENSG00000165457 150 EIF4EBP1 ENSG00000187840 FREM1 ENSG00000164946 151 ELOF1 ENSG00000130165 FRY ENSG00000073910 152 ELP2 ENSG00000134759 FTH1 ENSG00000167996 153 EMC3 ENSG00000125037 FUCA1 ENSG00000179163 154 ENGASE ENSG00000167280 GALC ENSG00000054983 155 EPC1 ENSG00000120616 GALNT1 ENSG00000141429 156 EPM2AIP1 ENSG00000178567 GALNT7 ENSG00000109586 157 ESD ENSG00000139684 GBP1 ENSG00000117228 158 EXOC3 ENSG00000180104 GDF10 ENSG00000107623 159 EXOSC10 ENSG00000171824 GLCE ENSG00000138604 160 FAM134C ENSG00000141699 GLIPR1 ENSG00000139278 161 FAM168B ENSG00000152102 GLIPR2 ENSG00000122694 162 FAM63A ENSG00000143409 GLS ENSG00000115419 163 FAM89B ENSG00000176973 GMFB ENSG00000197045 164 FBXO25 ENSG00000147364 GNB1 ENSG00000078369 165 FDFT1 ENSG00000079459 GNB4 ENSG00000114450 166 FEM1A ENSG00000141965 GNG12 ENSG00000172380 167 FGFRL1 ENSG00000127418 GNG2 ENSG00000186469 168 FHOD3 ENSG00000134775 GNPTAB ENSG00000111670 169 FNBP1L ENSG00000137942 GOLGA3 ENSG00000090615 170 FOXJ2 ENSG00000065970 GOLPH3 ENSG00000113384 171 FOXJ3 ENSG00000198815 GPC1 ENSG00000063660 172 FXR1 ENSG00000114416 GPR137B ENSG00000077585 173 GAB2 ENSG00000033327 GPR183 ENSG00000169508 174 GBAS ENSG00000146729 GRB14 ENSG00000115290 175 GCDH ENSG00000105607 GSPT1 ENSG00000103342 176 GEMIN4 ENSG00000179409 GTF2H5 ENSG00000272047 177 GINS3 ENSG00000181938 HAVCR2 ENSG00000135077 178 GJC1 ENSG00000182963 HCK ENSG00000101336 179 GLIS1 ENSG00000174332 HEG1 ENSG00000173706 180 GLUL ENSG00000135821 HIATL1 ENSG00000148110 181 GNA14 ENSG00000156049 HIPK1 ENSG00000163349 182 GNG7 ENSG00000176533 HMOX1 ENSG00000100292 183 GPATCH3 ENSG00000198746 HP ENSG00000257017 184 GPHN ENSG00000171723 HPGDS ENSG00000163106 185 GPI ENSG00000105220 HSD11B1 ENSG00000117594 186 GPN3 ENSG00000111231 HSPA13 ENSG00000155304 187 GPR146 ENSG00000164849 HSPB8 ENSG00000152137 188 GPRASP1 ENSG00000198932 HTATIP2 ENSG00000109854 189 GPT2 ENSG00000166123 HTATSF1 ENSG00000102241 190 GPX7 ENSG00000116157 HTR2B ENSG00000135914 191 GREB1L ENSG00000141449 ID4 ENSG00000172201 192 GRINA ENSG00000178719 IFI44 ENSG00000137965 193 GSDMB ENSG00000073605 IFIH1 ENSG00000115267 194 GTF3C5 ENSG00000148308 IGSF6 ENSG00000140749 195 GYG2 ENSG00000056998 IL10 ENSG00000136634 196 GYPC ENSG00000136732 IL10RA ENSG00000110324 197 H1F0 ENSG00000189060 IL1A ENSG00000115008 198 H1FX ENSG00000184897 IL1B ENSG00000125538 199 HADH ENSG00000138796 IL1RN ENSG00000136689 200 HDDC3 ENSG00000184508 IL8 ENSG00000169429 201 HDGFRP2 ENSG00000167674 INTS7 ENSG00000143493 202 HGS ENSG00000185359 IQGAP1 ENSG00000140575 203 HIGD2A ENSG00000146066 IQGAP2 ENSG00000145703 204 HMGB2 ENSG00000164104 IRAK4 ENSG00000198001 205 HMGXB4 ENSG00000100281 ITGAM ENSG00000169896 206 HN1L ENSG00000206053 ITGAV ENSG00000138448 207 HNRNPUL1 ENSG00000105323 ITGB5 ENSG00000082781 208 HSD17B10 ENSG00000072506 ITPRIPL2 ENSG00000205730 209 HSD17B8 ENSG00000204228 JAZF1 ENSG00000153814 210 HSPA1A ENSG00000204389 KAT2B ENSG00000114166 211 HSPB11 ENSG00000081870 KCND2 ENSG00000184408 212 HYI ENSG00000178922 KCNE3 ENSG00000175538 213 IDH3B ENSG00000101365 KCNJ2 ENSG00000123700 214 IDH3G ENSG00000067829 KIAA0930 ENSG00000100364 215 IFNGR2 ENSG00000159128 KIAA1598 ENSG00000187164 216 IFT46 ENSG00000118096 KIFAP3 ENSG00000075945 217 IGBP1 ENSG00000089289 KPNA3 ENSG00000102753 218 IGF1 ENSG00000017427 KRAS ENSG00000133703 219 IKZF4 ENSG00000123411 LAPTM5 ENSG00000162511 220 IL17C ENSG00000124391 LARS ENSG00000133706 221 IRAK3 ENSG00000090376 LCLAT1 ENSG00000172954 222 IRS2 ENSG00000185950 LCP1 ENSG00000136167 223 ISCA2 ENSG00000165898 LGMN ENSG00000100600 224 ITFG2 ENSG00000111203 LILRB2 ENSG00000131042 225 JMJD6 ENSG00000070495 LPCAT2 ENSG00000087253 226 JUND ENSG00000130522 LPGAT1 ENSG00000123684 227 KARS ENSG00000065427 LRRFIP1 ENSG00000124831 228 KDM1A ENSG00000004487 LYN ENSG00000254087 229 KDM4B ENSG00000127663 MAGT1 ENSG00000102158 230 KDM5B ENSG00000117139 MAK16 ENSG00000198042 231 KHDRBS1 ENSG00000121774 MAMDC2 ENSG00000165072 232 KIAA0922 ENSG00000121210 MAP1B ENSG00000131711 233 KLHDC2 ENSG00000165516 MAP2K1 ENSG00000169032 234 KLHDC9 ENSG00000162755 MAP4K3 ENSG00000011566 235 KLHL22 ENSG00000099910 MAP4K4 ENSG00000071054 236 KRTCAP2 ENSG00000163463 MAPK1 ENSG00000100030 237 LDHD ENSG00000166816 MARCO ENSG00000019169 238 LETMD1 ENSG00000050426 MCTP1 ENSG00000175471 239 LGALS12 ENSG00000133317 MED20 ENSG00000124641 240 LIAS ENSG00000121897 MEDAG ENSG00000102802 241 LIN7A ENSG00000111052 MFAP3 ENSG00000037749 242 LIX1L ENSG00000152022 MFAP4 ENSG00000166482 243 LMAN2 ENSG00000169223 MFAP5 ENSG00000197614 244 LPIN1 ENSG00000134324 MFHAS1 ENSG00000147324 245 LRP5 ENSG00000162337 MFSD1 ENSG00000118855 246 LRRC23 ENSG00000010626 MILR1 ENSG00000271605 247 LRRC41 ENSG00000132128 MOCS2 ENSG00000164172 248 LRRC47 ENSG00000130764 MPEG1 ENSG00000197629 249 LSM6 ENSG00000164167 MPZL1 ENSG00000197965 250 MACROD1 ENSG00000133315 MR1 ENSG00000153029 251 MACROD2 ENSG00000172264 MS4A4A ENSG00000110079 252 MAGI2 ENSG00000187391 MS4A6A ENSG00000110077 253 MALSU1 ENSG00000156928 MS4A7 ENSG00000166927 254 MAN2C1 ENSG00000140400 MSANTD3 ENSG00000066697 255 MAPRE2 ENSG00000166974 MSC ENSG00000178860 256 MBTD1 ENSG00000011258 MSL3 ENSG00000005302 257 MCM6 ENSG00000076003 MSN ENSG00000147065 258 MCM7 ENSG00000166508 MSRB3 ENSG00000174099 259 MDM4 ENSG00000198625 MXRA7 ENSG00000182534 260 MED12 ENSG00000184634 MYO5A ENSG00000197535 261 MED26 ENSG00000105085 MYO6 ENSG00000196586 262 MEN1 ENSG00000133895 NAAA ENSG00000138744 263 MESP1 ENSG00000166823 NABP1 ENSG00000173559 264 METTL22 ENSG00000067365 NAPG ENSG00000134265 265 MGMT ENSG00000170430 NAT1 ENSG00000171428 266 MKNK1 ENSG00000079277 NCEH1 ENSG00000144959 267 MKNK2 ENSG00000099875 NCF4 ENSG00000100365 268 MLYCD ENSG00000103150 NCOA7 ENSG00000111912 269 MPC1 ENSG00000060762 NDFIP1 ENSG00000131507 270 MPST ENSG00000128309 NEXN ENSG00000162614 271 MRPL10 ENSG00000159111 NLRP3 ENSG00000162711 272 MRPL16 ENSG00000166902 NMT2 ENSG00000152465 273 MRPL40 ENSG00000185608 NOL11 ENSG00000130935 274 MRPL41 ENSG00000182154 NPL ENSG00000135838 275 MRPL46 ENSG00000259494 NPY1R ENSG00000164128 276 MRPL9 ENSG00000143436 NQO1 ENSG00000181019 277 MRPS15 ENSG00000116898 NSF ENSG00000073969 278 MRPS18A ENSG00000096080 OSMR ENSG00000145623 279 MRPS2 ENSG00000122140 PAFAH1B1 ENSG00000007168 280 MRPS22 ENSG00000175110 PAG1 ENSG00000076641 281 MRPS30 ENSG00000112996 PAK1IP1 ENSG00000111845 282 MRPS31 ENSG00000102738 PALLD ENSG00000129116 283 MRPS34 ENSG00000074071 PAM ENSG00000145730 284 MRPS9 ENSG00000135972 PARP14 ENSG00000173193 285 MSRA ENSG00000175806 PARP9 ENSG00000138496 286 MSRB1 ENSG00000198736 PCDH19 ENSG00000165194 287 MTFR1L ENSG00000117640 PCDHB2 ENSG00000112852 288 MZT2B ENSG00000152082 PDE12 ENSG00000174840 289 NAALAD2 ENSG00000077616 PDE4DIP ENSG00000178104 290 NACA ENSG00000196531 PDGFA ENSG00000197461 291 NAPRT1 ENSG00000147813 PDLIM4 ENSG00000131435 292 NAT8L ENSG00000185818 PELI1 ENSG00000197329 293 NDRG4 ENSG00000103034 PERP ENSG00000112378 294 NDUFA12 ENSG00000184752 PGM2 ENSG00000169299 295 NDUFA6 ENSG00000184983 PHLDA1 ENSG00000139289 296 NDUFA7 ENSG00000167774 PHLDA2 ENSG00000181649 297 NDUFA8 ENSG00000119421 PIGX ENSG00000163964 298 NDUFAB1 ENSG00000004779 PIK3AP1 ENSG00000155629 299 NDUFB4 ENSG00000065518 PIP4K2A ENSG00000150867 300 NDUFB5 ENSG00000136521 PITPNA ENSG00000174238 301 NDUFB8 ENSG00000255339 PKD2 ENSG00000118762 302 NDUFS3 ENSG00000213619 PLA2G4A ENSG00000116711 303 NELFCD ENSG00000101158 PLAC9 ENSG00000189129 304 NFU1 ENSG00000169599 PLAUR ENSG00000011422 305 NONO ENSG00000147140 PLEK ENSG00000115956 306 NPR1 ENSG00000169418 PLEKHA1 ENSG00000107679 307 NPRL3 ENSG00000103148 PLS3 ENSG00000102024 308 NR3C1 ENSG00000113580 PLXNA1 ENSG00000114554 309 NRIP1 ENSG00000180530 PNMAL1 ENSG00000182013 310 NUDT6 ENSG00000170917 POLR2K ENSG00000147669 311 OLFM2 ENSG00000105088 PPP1R12A ENSG00000058272 312 OPLAH ENSG00000178814 PPP1R21 ENSG00000162869 313 ORAI3 ENSG00000175938 PPP2R5C ENSG00000078304 314 ORMDL3 ENSG00000172057 PPT1 ENSG00000131238 315 OSBPL1A ENSG00000141447 PRDX1 ENSG00000117450 316 OXA1L ENSG00000155463 PSD3 ENSG00000156011 317 OXNAD1 ENSG00000154814 PTGFR ENSG00000122420 318 PARK7 ENSG00000116288 PTPRB ENSG00000127329 319 PC ENSG00000173599 RAB1A ENSG00000138069 320 PCBD1 ENSG00000166228 RAB22A ENSG00000124209 321 PCCB ENSG00000114054 RAB27A ENSG00000069974 322 PCK1 ENSG00000124253 RAB2A ENSG00000104388 323 PCNT ENSG00000160299 RAB31 ENSG00000168461 324 PCYT2 ENSG00000185813 RAB7A ENSG00000075785 325 PDK2 ENSG00000005882 RAB9A ENSG00000123595 326 PDXK ENSG00000160209 RAC1 ENSG00000136238 327 PER1 ENSG00000179094 RAP2A ENSG00000125249 328 PES1 ENSG00000100029 RASGEF1B ENSG00000138670 329 PET112 ENSG00000059691 REEP5 ENSG00000129625 330 PFKFB3 ENSG00000170525 RERG ENSG00000134533 331 PFKL ENSG00000141959 RGS1 ENSG00000090104 332 PGLS ENSG00000130313 RHOQ ENSG00000119729 333 PHB2 ENSG00000215021 RNASE1 ENSG00000129538 334 PHIP ENSG00000146247 RNASE6 ENSG00000169413 335 PHLDA3 ENSG00000174307 RNF182 ENSG00000180537 336 PHLDB2 ENSG00000144824 RPP40 ENSG00000124787 337 PIEZO1 ENSG00000103335 RPS27L ENSG00000185088 338 PINX1 ENSG00000254093 RPS6KA3 ENSG00000177189 339 PITRM1 ENSG00000107959 RRM2B ENSG00000048392 340 PKNOX2 ENSG00000165495 S100A11 ENSG00000163191 341 PLD1 ENSG00000075651 S100A4 ENSG00000196154 342 PLEKHG6 ENSG00000008323 SAMHD1 ENSG00000101347 343 PLEKHJ1 ENSG00000104886 SASS6 ENSG00000156876 344 PMM1 ENSG00000100417 SCPEP1 ENSG00000121064 345 PNPLA2 ENSG00000177666 SEC23B ENSG00000101310 346 POLDIP2 ENSG00000004142 SEC23IP ENSG00000107651 347 POLR1D ENSG00000186184 SEC24D ENSG00000150961 348 POLR2C ENSG00000102978 SEC63 ENSG00000025796 349 POLR3C ENSG00000186141 SELE ENSG00000007908 350 PPIF ENSG00000108179 SEMA3C ENSG00000075223 351 PPP1R16A ENSG00000160972 SERPINE1 ENSG00000106366 352 PPP1R3C ENSG00000119938 SGK1 ENSG00000118515 353 PPP1R8 ENSG00000117751 SGMS1 ENSG00000198964 354 PPP2R5D ENSG00000112640 SGMS2 ENSG00000164023 355 PPP6R2 ENSG00000100239 SGPP1 ENSG00000126821 356 PRDX6 ENSG00000117592 SIGLEC1 ENSG00000088827 357 PRIMA1 ENSG00000175785 SKAP2 ENSG00000005020 358 PRKCSH ENSG00000130175 SLC11A2 ENSG00000110911 359 PRPF8 ENSG00000174231 SLC18B1 ENSG00000146409 360 PRPSAP1 ENSG00000161542 SLC25A30 ENSG00000174032 361 PRRC2A ENSG00000204469 SLC25A37 ENSG00000147454 362 PRUNE2 ENSG00000106772 SLC25A43 ENSG00000077713 363 PSMC5 ENSG00000087191 SLC26A2 ENSG00000155850 364 PSMG2 ENSG00000128789 SLC35B3 ENSG00000124786 365 PTGR1 ENSG00000106853 SLC37A3 ENSG00000157800 366 PTMS ENSG00000159335 SLC39A10 ENSG00000196950 367 PTOV1 ENSG00000104960 SLC39A6 ENSG00000141424 368 PTPN3 ENSG00000070159 SLC7A7 ENSG00000155465 369 PTPRG ENSG00000144724 SLIT2 ENSG00000145147 370 PXMP2 ENSG00000176894 SLIT3 ENSG00000184347 371 PYGM ENSG00000068976 SMIM14 ENSG00000163683 372 RAD23A ENSG00000179262 SOBP ENSG00000112320 373 RAP1GDS1 ENSG00000138698 SOCS5 ENSG00000171150 374 RARRES2 ENSG00000106538 SOX7 ENSG00000171056 375 RASD1 ENSG00000108551 SPRYD3 ENSG00000167778 376 RBP4 ENSG00000138207 SRGN ENSG00000122862 377 RBP7 ENSG00000162444 SRPX2 ENSG00000102359 378 RBPMS ENSG00000157110 SRXN1 ENSG00000271303 379 RCL1 ENSG00000120158 STAT3 ENSG00000168610 380 REPS1 ENSG00000135597 STK17B ENSG00000081320 381 RGMA ENSG00000182175 STK38L ENSG00000211455 382 RGS22 ENSG00000132554 STS ENSG00000101846 383 RGS3 ENSG00000138835 STX2 ENSG00000111450 384 RING1 ENSG00000204227 SULT1A1 ENSG00000196502 385 RNF130 ENSG00000113269 SWAP70 ENSG00000133789 386 RNF144A ENSG00000151692 SYNM ENSG00000182253 387 RNF157 ENSG00000141576 TAOK1 ENSG00000160551 388 RNF169 ENSG00000166439 TENM4 ENSG00000149256 389 RNF31 ENSG00000092098 TES ENSG00000135269 390 ROBO1 ENSG00000169855 TFDP1 ENSG00000198176 391 RP9 ENSG00000164610 TFEC ENSG00000105967 392 RPAIN ENSG00000129197 THBD ENSG00000178726 393 RPL14 ENSG00000188846 THEMIS2 ENSG00000130775 394 RPL22 ENSG00000116251 TLCD2 ENSG00000185561 395 RPS20 ENSG00000008988 TLE2 ENSG00000065717 396 RSBN1 ENSG00000081019 TM6SF1 ENSG00000136404 397 RTCB ENSG00000100220 TM9SF3 ENSG00000077147 398 RWDD1 ENSG00000111832 TMCC1 ENSG00000172765 399 RWDD2A ENSG00000013392 TMED10 ENSG00000170348 400 RXRA ENSG00000186350 TMEM159 ENSG00000011638 401 SCRN2 ENSG00000141295 TMEM181 ENSG00000146433 402 SDHB ENSG00000117118 TMEM206 ENSG00000065600 403 SELO ENSG00000073169 TMEM33 ENSG00000109133 404 SEMA3A ENSG00000075213 TMEM87B ENSG00000153214 405 SERPINB6 ENSG00000124570 TMEM9B ENSG00000175348 406 SF3A1 ENSG00000099995 TMOD3 ENSG00000138594 407 SF3A2 ENSG00000104897 TNF ENSG00000232810 408 SF3B2 ENSG00000087365 TNFAIP3 ENSG00000118503 409 SFXN2 ENSG00000156398 TNFRSF10A ENSG00000104689 410 SGSM3 ENSG00000100359 TNFRSF11B ENSG00000164761 411 SH3GL1 ENSG00000141985 TNFRSF1B ENSG00000028137 412 SH3KBP1 ENSG00000147010 TNMD ENSG00000000005 413 SHMT1 ENSG00000176974 TPBG ENSG00000146242 414 SIAH2 ENSG00000181788 TPD52 ENSG00000076554 415 SIRT5 ENSG00000124523 TPMT ENSG00000137364 416 SIVA1 ENSG00000184990 TPST2 ENSG00000128294 417 SLC16A1 ENSG00000155380 TRAF3IP1 ENSG00000204104 418 SLC19A3 ENSG00000135917 TRAM2 ENSG00000065308 419 SLC25A1 ENSG00000100075 TSPAN12 ENSG00000106025 420 SLC25A11 ENSG00000108528 TUBB2A ENSG00000137267 421 SLC25A25 ENSG00000148339 TUBB2B ENSG00000137285 422 SLC25A38 ENSG00000144659 TXNDC15 ENSG00000113621 423 SLC27A2 ENSG00000140284 TXNDC9 ENSG00000115514 424 SLC2A4 ENSG00000181856 TXNRD1 ENSG00000198431 425 SLC43A1 ENSG00000149150 TYROBP ENSG00000011600 426 SLC4A4 ENSG00000080493 UBP1 ENSG00000153560 427 SLC50A1 ENSG00000169241 UBR1 ENSG00000159459 428 SMDT1 ENSG00000183172 UBTD2 ENSG00000168246 429 SMIM7 ENSG00000214046 UCHL1 ENSG00000154277 430 SNAP29 ENSG00000099940 UGDH ENSG00000109814 431 SNRNP27 ENSG00000124380 UGGT1 ENSG00000136731 432 SNRNP70 ENSG00000104852 UHMK1 ENSG00000152332 433 SNRPA ENSG00000077312 UTP14C ENSG00000253797 434 SP1 ENSG00000185591 VAMP8 ENSG00000118640 435 SPG11 ENSG00000104133 VCAN ENSG00000038427 436 SPSB3 ENSG00000162032 VGLL3 ENSG00000206538 437 SRP68 ENSG00000167881 VSIG4 ENSG00000155659 438 SRRT ENSG00000087087 WDR26 ENSG00000162923 439 SRSF4 ENSG00000116350 WDR41 ENSG00000164253 440 SRSF5 ENSG00000100650 WIPF1 ENSG00000115935 441 SRSF9 ENSG00000111786 WSB2 ENSG00000176871 442 STAT5A ENSG00000126561 XPOT ENSG00000184575 443 STK24 ENSG00000102572 YWHAH ENSG00000128245 444 STK25 ENSG00000115694 ZDHHC2 ENSG00000104219 445 STOML2 ENSG00000165283 ZFP91 ENSG00000186660 446 STOX1 ENSG00000165730 ZNF385D ENSG00000151789 447 STUB1 ENSG00000103266 ZNF830 ENSG00000198783 448 STXBP1 ENSG00000136854 LOC100132891 ENSG00000235531 449 SUCLG1 ENSG00000163541 LOXL1-AS1 ENSG00000261801 450 SULF1 ENSG00000137573 LINC00968 ENSG00000246430 451 SUMF2 ENSG00000129103 MIR155HG ENSG00000234883 452 SUOX ENSG00000139531 LINC00936 ENSG00000271614 453 SUPT6H ENSG00000109111 LINC00667 ENSG00000263753 454 SVIL ENSG00000197321 ZBED5-AS1 ENSG00000247271 455 SYT17 ENSG00000103528 456 TADA1 ENSG00000152382 457 TBC1D10B ENSG00000169221 458 TBC1D20 ENSG00000125875 459 TBCA ENSG00000171530 460 TCEB3 ENSG00000011007 461 TCF25 ENSG00000141002 462 TCF7L1 ENSG00000152284 463 TERF2IP ENSG00000166848 464 TEX261 ENSG00000144043 465 TF ENSG00000091513 466 THAP7 ENSG00000184436 467 THYN1 ENSG00000151500 468 TIMM50 ENSG00000105197 469 TKT ENSG00000163931 470 TM7SF2 ENSG00000149809 471 TMEM106C ENSG00000134291 472 TMEM132C ENSG00000181234 473 TMEM53 ENSG00000126106 474 TNS1 ENSG00000079308 475 TOMM6 ENSG00000214736 476 TOMM7 ENSG00000196683 477 TPI1 ENSG00000111669 478 TPRG1L ENSG00000158109 479 TRAP1 ENSG00000126602 480 TSC1 ENSG00000165699 481 TSPYL2 ENSG00000184205 482 TUBG2 ENSG00000037042 483 TWIST1 ENSG00000122691 484 TXN2 ENSG00000100348 485 U2SURP ENSG00000163714 486 UBA52 ENSG00000221983 487 UBALD2 ENSG00000185262 488 UBC ENSG00000150991 489 UBE2M ENSG00000130725 490 UBE2R2 ENSG00000107341 491 UBE4B ENSG00000130939 492 UBTD1 ENSG00000165886 493 UBXN1 ENSG00000162191 494 ULK1 ENSG00000177169 495 UQCRC1 ENSG00000010256 496 UQCRC2 ENSG00000140740 497 USP30 ENSG00000135093 498 VARS2 ENSG00000137411 499 VEGFA ENSG00000112715 500 VPS26B ENSG00000151502 501 VRK3 ENSG00000105053 502 WDR33 ENSG00000136709 503 WDR83OS ENSG00000105583 504 WDR86 ENSG00000187260 505 XRCC1 ENSG00000073050 506 XRCC2 ENSG00000196584 507 YPEL1 ENSG00000100027 508 YPEL3 ENSG00000090238 509 YPEL5 ENSG00000119801 510 ZBED1 ENSG00000214717 511 ZBTB5 ENSG00000168795 512 ZGPAT ENSG00000197114 513 ZNF136 ENSG00000196646 514 ZNF266 ENSG00000174652 515 ZNF34 ENSG00000196378 516 ZNF384 ENSG00000126746 517 ZNF507 ENSG00000168813 518 ZNF576 ENSG00000124444 519 ZNF581 ENSG00000171425 520 ZNF622 ENSG00000173545 521 ZNHIT3 ENSG00000108278 522 ZRSR2 ENSG00000169249 523 ZSCAN31 ENSG00000235109 524 SNHG8 ENSG00000269893 525 PRKAG2-AS1 100505483 526 TMEM161B-AS1 ENSG00000247828 527 HEIH ENSG00000278970 528 MMP24-AS1 101410538 529 LOC101928061 ENSG00000120742 530 PKD1L2 ENSG00000166473 531 AGAP11 119385 532 LRRC75A-AS1 ENSG00000175061 533 IGLV4-3 28786 534 MRPL57 ENSG00000173141 535 SNHG7 ENSG00000233016 536 SNHG12 ENSG00000197989 537 FLJ20021 ENSG00000254531 538 ST7-AS1 ENSG00000227199 Supplementary data S7B Adipose tissue - Significantly changed and consistently up- or downregulated transcripts in the heavier twins compared with their leaner co-twins Adipose Tissue Ensembl Genes Adipose Tissue Ensembl Genes Downregulated Upregulated Genes Genes 1 AATF ENSG00000108270 ACO2 ENSG00000100412 2 ABCA8 ENSG00000141338 ADORA3 ENSG00000121933 3 ACSM1 ENSG00000166743 ALPP ENSG00000163283 4 ADCY10 ENSG00000143199 ANKRD27 ENSG00000105186 5 ADORA1 ENSG00000163485 AP2A2 ENSG00000183020 6 AFF2 ENSG00000155966 APOBEC3B ENSG00000179750 7 AGTRAP ENSG00000177674 ARID1B ENSG00000049618 8 AKAP13 ENSG00000170776 ARRDC3 ENSG00000113369 9 AKIRIN1 ENSG00000174574 ASAH1 ENSG00000104763 10 ALDH5A1 ENSG00000112294 ASPSCR1 ENSG00000169696 11 ALDOB ENSG00000136872 B3GALT5 ENSG00000183778 12 ALPK3 ENSG00000136383 BAG4 ENSG00000156735 13 AMMECR1L ENSG00000144233 BCAS4 ENSG00000124243 14 AMPD1 ENSG00000116748 BSPRY ENSG00000119411 15 ANAPC13 ENSG00000129055 C10orf32 ENSG00000166275 16 ANAPC2 ENSG00000176248 C15orf57 ENSG00000128891 17 ANKRD65 ENSG00000235098 C17orf53 ENSG00000125319 18 ANXA13 ENSG00000104537 C19orf24 ENSG00000228300 19 ANXA2 ENSG00000182718 C1D ENSG00000197223 20 APOF ENSG00000175336 C3orf58 ENSG00000181744 21 ARC ENSG00000198576 C5orf46 ENSG00000178776 22 ARRB1 ENSG00000137486 C5orf63 ENSG00000164241 23 ASPRV1 ENSG00000244617 C8orf4 ENSG00000176907 24 ATM ENSG00000149311 C9orf24 ENSG00000164972 25 ATP1A4 ENSG00000132681 CCL18 ENSG00000006074 26 ATXN7L3B ENSG00000253719 CCNE2 ENSG00000175305 27 BCKDHA ENSG00000248098 CD1B ENSG00000158485 28 BEND7 ENSG00000165626 CD40LG ENSG00000102245 29 BIN1 ENSG00000136717 CD99 ENSG00000002586 30 BRCA1 ENSG00000012048 CDR2L ENSG00000109089 31 BRD4 ENSG00000141867 CIPC ENSG00000198894 32 BST1 ENSG00000109743 CLEC5A ENSG00000258227 33 BTBD7 ENSG00000011114 COPZ1 ENSG00000111481 34 C10orf11 ENSG00000148655 CR2 ENSG00000117322 35 C10orf53 ENSG00000178645 CRNKL1 ENSG00000101343 36 C11orf73 ENSG00000149196 CT83 ENSG00000204019 37 C15orf65 ENSG00000261652 CXXC5 ENSG00000171604 38 C19orf66 ENSG00000130813 CYB5R3 ENSG00000100243 39 C1orf27 ENSG00000157181 DCAF11 ENSG00000100897 40 C1orf43 ENSG00000143612 DEPDC7 ENSG00000121690 41 C1QL1 ENSG00000131094 DHRS11 ENSG00000108272 42 C20orf194 ENSG00000088854 DICER1 ENSG00000100697 43 C22orf26 ENSG00000182257 DIRAS2 ENSG00000165023 44 C3orf79 ENSG00000237787 EGLN3 ENSG00000129521 45 C4orf36 ENSG00000163633 EIF6 ENSG00000242372 46 C7orf25 ENSG00000136197 ELFN1 ENSG00000225968 47 C9orf37 ENSG00000203993 ENPP6 ENSG00000164303 48 C9orf84 ENSG00000165181 EPAS1 ENSG00000116016 49 CA2 ENSG00000104267 EPS8L1 ENSG00000131037 50 CADM1 ENSG00000182985 ESRRG ENSG00000196482 51 CALCR ENSG00000004948 F12 ENSG00000131187 52 CAMK2A ENSG00000070808 FAM200A ENSG00000221909 53 CASC1 ENSG00000118307 FAM3A ENSG00000071889 54 CASS4 ENSG00000087589 FSTL5 ENSG00000168843 55 CBFB ENSG00000067955 GABRA5 ENSG00000186297 56 CBX5 ENSG00000094916 GAN ENSG00000261609 57 CCDC114 ENSG00000105479 GBP2 ENSG00000162645 58 CCDC62 ENSG00000130783 GDF9 ENSG00000164404 59 CCSER2 ENSG00000107771 GLYATL2 ENSG00000156689 60 CCT5 ENSG00000150753 GMDS ENSG00000112699 61 CCT6B ENSG00000132141 GNA11 ENSG00000088256 62 CCT7 ENSG00000135624 GNPDA1 ENSG00000113552 63 CD1A ENSG00000158477 GOLGA2 ENSG00000167110 64 CDH7 ENSG00000081138 GP9 ENSG00000169704 65 CDHR3 ENSG00000128536 GTF2B ENSG00000137947 66 CDK14 ENSG00000058091 GTF3C1 ENSG00000077235 67 CDO1 ENSG00000129596 H2BFM ENSG00000101812 68 CECR6 ENSG00000183307 HAPLN4 ENSG00000187664 69 CENPL ENSG00000120334 HEYL ENSG00000163909 70 CEP135 ENSG00000174799 HGFAC ENSG00000109758 71 CHD6 ENSG00000124177 HHEX ENSG00000152804 72 CHD9 ENSG00000177200 HIST1H2BA ENSG00000146047 73 CHDH ENSG00000016391 HMMR ENSG00000072571 74 CHRNA1 ENSG00000138435 HPX ENSG00000110169 75 CHRNB1 ENSG00000170175 IFNL1 ENSG00000182393 76 CIRBP ENSG00000099622 IKBKAP ENSG00000070061 77 CKAP2 ENSG00000136108 IL12RB1 ENSG00000096996 78 CKB ENSG00000166165 IL25 ENSG00000166090 79 CLDN2 ENSG00000165376 IL3 ENSG00000164399 80 CLGN ENSG00000153132 INTS6 ENSG00000102786 81 CLSTN3 ENSG00000139182 IQCF5 ENSG00000214681 82 CMTR1 ENSG00000137200 IQGAP3 ENSG00000183856 83 COG7 ENSG00000168434 IRF6 ENSG00000117595 84 COL8A2 ENSG00000171812 JAZF1 ENSG00000153814 85 COPG2 ENSG00000158623 KBTBD8 ENSG00000163376 86 COPS5 ENSG00000121022 KCNJ1 ENSG00000151704 87 COPS7A ENSG00000111652 KCNN3 ENSG00000143603 88 COPS7B ENSG00000144524 KCNT1 ENSG00000107147 89 CPEB3 ENSG00000107864 KHDC1 ENSG00000135314 90 CPXM1 ENSG00000088882 KIAA0125 ENSG00000226777 91 CRB2 ENSG00000148204 KRT72 ENSG00000170486 92 CREG1 ENSG00000143162 LAMC1 ENSG00000135862 93 CRELD1 ENSG00000163703 LILRA2 ENSG00000239998 94 CRTC1 ENSG00000105662 LRFN3 ENSG00000126243 95 CSMD3 ENSG00000164796 LSM4 ENSG00000130520 96 CTRC ENSG00000162438 LY6K ENSG00000160886 97 CTSL ENSG00000135047 MAP1A ENSG00000166963 98 CYP4A11 ENSG00000187048 MAP2 ENSG00000078018 99 CYS1 ENSG00000205795 MAP4K1 ENSG00000104814 100 DBF4B ENSG00000161692 MAP4K2 ENSG00000168067 101 DBNDD1 ENSG00000003249 METTL21B ENSG00000123427 102 DBR1 ENSG00000138231 METTL8 ENSG00000123600 103 DCAF7 ENSG00000136485 MFAP4 ENSG00000166482 104 DCTN5 ENSG00000166847 MICAL2 ENSG00000133816 105 DCTPP1 ENSG00000179958 MID1IP1 ENSG00000165175 106 DDA1 ENSG00000130311 MMACHC ENSG00000132763 107 DENND2C ENSG00000175984 MON2 ENSG00000061987 108 DGAT1 ENSG00000185000 MRE11A ENSG00000020922 109 DHRS2 ENSG00000100867 MROH6 ENSG00000204839 110 DHRS7 ENSG00000100612 MRPL33 ENSG00000243147 111 DKC1 ENSG00000130826 MS4A8 ENSG00000166959 112 DMRT2 ENSG00000173253 MSMB ENSG00000138294 113 DNAH1 ENSG00000114841 MYLK ENSG00000065534 114 DNALI1 ENSG00000163879 NDRG1 ENSG00000104419 115 DSG1 ENSG00000134760 NFE2 ENSG00000123405 116 DUSP3 ENSG00000108861 NKAIN1 ENSG00000084628 117 EEF1D ENSG00000104529 NLRP3 ENSG00000162711 118 EEF2 ENSG00000167658 NOL9 ENSG00000162408 119 EHD1 ENSG00000110047 NOXRED1 ENSG00000165555 120 EIF2B3 ENSG00000070785 NPTX2 ENSG00000106236 121 EIF2S2 ENSG00000125977 NR1H2 ENSG00000131408 122 EIF3G ENSG00000130811 NR5A2 ENSG00000116833 123 EIF4E ENSG00000151247 NUFIP2 ENSG00000108256 124 EMC3 ENSG00000125037 NUP107 ENSG00000111581 125 ERGIC3 ENSG00000125991 NUP205 ENSG00000155561 126 ERI1 ENSG00000104626 OSER1 ENSG00000132823 127 EVA1A ENSG00000115363 OXLD1 ENSG00000204237 128 EXOC6B ENSG00000144036 PAEP ENSG00000122133 129 EXOC7 ENSG00000182473 PALLD ENSG00000129116 130 EYS ENSG00000188107 PARP2 ENSG00000129484 131 FAM134B ENSG00000154153 PDE5A ENSG00000138735 132 FAM171B ENSG00000144369 PHACTR4 ENSG00000204138 133 FAM53A ENSG00000174137 PHAX ENSG00000164902 134 FAM73B ENSG00000148343 PLCG1 ENSG00000124181 135 FARS2 ENSG00000145982 PLEKHB1 ENSG00000021300 136 FBL ENSG00000105202 POFUT1 ENSG00000101346 137 FBXO34 ENSG00000178974 POLR2J ENSG00000005075 138 FKBP14 ENSG00000106080 POU6F1 ENSG00000184271 139 FKTN ENSG00000106692 PPP1R3D ENSG00000132825 140 FNDC3A ENSG00000102531 PRKD1 ENSG00000184304 141 FOXJ3 ENSG00000198815 PRSS22 ENSG00000005001 142 FOXN4 ENSG00000139445 PSMB3 ENSG00000108294 143 FOXS1 ENSG00000179772 PSMD4 ENSG00000159352 144 GATAD2A ENSG00000167491 PTCH2 ENSG00000117425 145 GBGT1 ENSG00000148288 PTRHD1 ENSG00000184924 146 GCH1 ENSG00000131979 RAB1A ENSG00000138069 147 GCNT2 ENSG00000111846 RAB21 ENSG00000080371 148 GEN1 ENSG00000178295 RAMP3 ENSG00000122679 149 GNG5 ENSG00000174021 RASL10A ENSG00000100276 150 GNPDA2 ENSG00000163281 RBM24 ENSG00000112183 151 GOSR2 ENSG00000108433 RPGRIP1L ENSG00000103494 152 GOT1 ENSG00000120053 S100PBP ENSG00000116497 153 GPN3 ENSG00000111231 SCARF1 ENSG00000074660 154 GPR112 ENSG00000156920 SCN8A ENSG00000196876 155 GPR143 ENSG00000101850 SCYL3 ENSG00000000457 156 GRAMD3 ENSG00000155324 SELL ENSG00000188404 157 GRINA ENSG00000178719 SENP6 ENSG00000112701 158 GSTA1 ENSG00000243955 SFXN4 ENSG00000183605 159 GSX1 ENSG00000169840 SIRT6 ENSG00000077463 160 GTF3C5 ENSG00000148308 SLC16A3 ENSG00000141526 161 HADHB ENSG00000138029 SLC25A12 ENSG00000115840 162 HAP1 ENSG00000173805 SLC25A35 ENSG00000125434 163 HAUS4 ENSG00000092036 SLCO4A1 ENSG00000101187 164 HDAC4 ENSG00000068024 SNCG ENSG00000173267 165 HDAC8 ENSG00000147099 SNX25 ENSG00000109762 166 HECTD3 ENSG00000126107 SP140L ENSG00000185404 167 HIST1H2BH ENSG00000197459 STAMBP ENSG00000124356 168 HMGB1 ENSG00000189403 SUMO1 ENSG00000116030 169 HNRNPA0 ENSG00000177733 SUMO3 ENSG00000184900 170 HSF1 ENSG00000185122 TAF4B ENSG00000141384 171 IARS2 ENSG00000067704 TCERG1L ENSG00000176769 172 IDO1 ENSG00000131203 TECTB ENSG00000119913 173 IFT140 ENSG00000187535 TEK ENSG00000120156 174 IGFBP6 ENSG00000167779 TEKT2 ENSG00000092850 175 IGSF8 ENSG00000162729 TFDP2 ENSG00000114126 176 IL23A ENSG00000110944 TMEM102 ENSG00000181284 177 INSM1 ENSG00000173404 TMEM110 ENSG00000213533 178 INSRR ENSG00000027644 TMEM254 ENSG00000133678 179 IRAK1BP1 ENSG00000146243 TNFAIP6 ENSG00000123610 180 IRF7 ENSG00000185507 TNFSF18 ENSG00000120337 181 JDP2 ENSG00000140044 TP53INP2 ENSG00000078804 182 KBTBD3 ENSG00000182359 TPBG ENSG00000146242 183 KCNB2 ENSG00000182674 TPRG1L ENSG00000158109 184 KCNMB2 ENSG00000197584 TRAF2 ENSG00000127191 185 KDELC1 ENSG00000134901 TSSC1 ENSG00000032389 186 KHK ENSG00000138030 TTC36 ENSG00000172425 187 KIF1A ENSG00000130294 TTF2 ENSG00000116830 188 KITLG ENSG00000049130 TUBA1B ENSG00000123416 189 KLHL10 ENSG00000161594 TUBA3C ENSG00000198033 190 KLHL13 ENSG00000003096 TXNDC15 ENSG00000113621 191 KLHL2 ENSG00000109466 UBE2G1 ENSG00000132388 192 KLHL5 ENSG00000109790 UBTF ENSG00000108312 193 KRR1 ENSG00000111615 UPF2 ENSG00000151461 194 KRT2 ENSG00000172867 USP12 ENSG00000152484 195 KRT40 ENSG00000204889 VEPH1 ENSG00000197415 196 LARP4 ENSG00000161813 VNN2 ENSG00000112303 197 LAS1L ENSG00000001497 ZFP92 ENSG00000189420 198 LDLR ENSG00000130164 ZNF382 ENSG00000161298 199 LEMD3 ENSG00000174106 ZNF398 ENSG00000197024 200 LENG9 ENSG00000182909 ZNF451 ENSG00000112200 201 LIPE ENSG00000079435 ZNF554 ENSG00000172006 202 LMBRD2 ENSG00000164187 ZNF646 ENSG00000167395 203 LMOD3 ENSG00000163380 ZNF740 ENSG00000139651 204 LPHN3 ENSG00000150471 ZNF804B ENSG00000182348 205 LRIF1 ENSG00000121931 ZSWIM1 ENSG00000168612 206 LRRC36 ENSG00000159708 IPO5P1 207 LRRC46 ENSG00000141294 LINC00942 208 LRRC8A ENSG00000136802 LOC100505711 209 LRRN3 ENSG00000173114 PLAC4 210 LSM6 ENSG00000164167 TMEM254-AS1 211 M6PR ENSG00000003056 LOC284600 212 MAN1C1 ENSG00000117643 RP5-1043L13.1 213 MANEAL ENSG00000185090 PRR7-AS1 214 MAST4 ENSG00000069020 IPW 215 MBLAC2 ENSG00000176055 LINC00615 216 MED24 ENSG00000008838 CES1P1 217 MEIS1 ENSG00000143995 PVT1 218 MKI67 ENSG00000148773 LOC729683 219 MKRN1 ENSG00000133606 RUNX1-IT1 220 MKRN2 ENSG00000075975 LINC00467 221 MMEL1 ENSG00000142606 BFSP2-AS1 222 MPC2 ENSG00000143158 223 MPP3 ENSG00000161647 224 MRPL23 ENSG00000214026 225 MRPL41 ENSG00000182154 226 MRPL9 ENSG00000143436 227 MRPS11 ENSG00000181991 228 MRPS9 ENSG00000135972 229 MS4A3 ENSG00000149516 230 MSMO1 ENSG00000052802 231 MTHFR ENSG00000177000 232 MTMR1 ENSG00000063601 233 MYO16 ENSG00000041515 234 NAALADL2 ENSG00000177694 235 NARG2 ENSG00000128915 236 NCOA3 ENSG00000124151 237 NCOA6 ENSG00000198646 238 NCS1 ENSG00000107130 239 NDFIP1 ENSG00000131507 240 NDUFB7 ENSG00000099795 241 NDUFB9 ENSG00000147684 242 NDUFS2 ENSG00000158864 243 NDUFV1 ENSG00000167792 244 NDUFV3 ENSG00000160194 245 NES ENSG00000132688 246 NIP7 ENSG00000132603 247 NOA1 ENSG00000084092 248 NOL6 ENSG00000165271 249 NUDT16 ENSG00000198585 250 NUSAP1 ENSG00000137804 251 NXPH2 ENSG00000144227 252 OAS1 ENSG00000089127 253 OCIAD1 ENSG00000109180 254 OLFML3 ENSG00000116774 255 ORMDL1 ENSG00000128699 256 P2RY10 ENSG00000078589 257 PBK ENSG00000168078 258 PBX3 ENSG00000167081 259 PBX4 ENSG00000105717 260 PC ENSG00000173599 261 PCDH9 ENSG00000184226 262 PCED1A ENSG00000132635 263 PCMTD1 ENSG00000168300 264 PDK2 ENSG00000005882 265 PENK ENSG00000181195 266 PEPD ENSG00000124299 267 PES1 ENSG00000100029 268 PEX11A ENSG00000166821 269 PFDN1 ENSG00000113068 270 PFKFB2 ENSG00000123836 271 PGBD4 ENSG00000182405 272 PGLYRP3 ENSG00000159527 273 PHF20 ENSG00000025293 274 PHKG2 ENSG00000156873 275 PHLPP2 ENSG00000040199 276 PID1 ENSG00000153823 277 PLA2G2D ENSG00000117215 278 PLA2G5 ENSG00000127472 279 PLD4 ENSG00000166428 280 PLEKHH3 ENSG00000068137 281 PML ENSG00000140464 282 PMPCA ENSG00000165688 283 PMVK ENSG00000163344 284 POLR3G ENSG00000113356 285 POLR3GL ENSG00000121851 286 POPDC3 ENSG00000132429 287 POSTN ENSG00000133110 288 POU2AF1 ENSG00000110777 289 PPDPF ENSG00000125534 290 PPIL1 ENSG00000137168 291 PPP1CA ENSG00000172531 292 PPP2R4 ENSG00000119383 293 PPP2R5C ENSG00000078304 294 PPP6R2 ENSG00000100239 295 PRRG2 ENSG00000126460 296 PSMD5 ENSG00000095261 297 PSMG1 ENSG00000183527 298 PTGFR ENSG00000122420 299 PTH2R ENSG00000144407 300 PTPRF ENSG00000142949 301 PZP ENSG00000126838 302 RAB10 ENSG00000084733 303 RAB11FIP3 ENSG00000090565 304 RABGGTA ENSG00000100949 305 RAD17 ENSG00000152942 306 RALGAPB ENSG00000170471 307 RAP1GAP ENSG00000076864 308 RC3H2 ENSG00000056586 309 RCC1 ENSG00000180198 310 RCN3 ENSG00000142552 311 REEP2 ENSG00000132563 312 REG3G ENSG00000143954 313 REV3L ENSG00000009413 314 RFC4 ENSG00000163918 315 RGS2 ENSG00000116741 316 RHOC ENSG00000155366 317 RHOH ENSG00000168421 318 RMDN1 ENSG00000176623 319 RMDN3 ENSG00000137824 320 RNF144A ENSG00000151692 321 RNF220 ENSG00000187147 322 RNF31 ENSG00000092098 323 RNF4 ENSG00000063978 324 ROBO4 ENSG00000154133 325 RORA ENSG00000069667 326 RPL10 ENSG00000147403 327 RPS11 ENSG00000142534 328 S100A12 ENSG00000163221 329 SAV1 ENSG00000151748 330 SCPEP1 ENSG00000121064 331 SEMA3C ENSG00000075223 332 SERPINB10 ENSG00000242550 333 SGPP2 ENSG00000163082 334 SIRT3 ENSG00000142082 335 SLAMF6 ENSG00000162739 336 SLC12A9 ENSG00000146828 337 SLC19A3 ENSG00000135917 338 SLC1A3 ENSG00000079215 339 SLC25A22 ENSG00000177542 340 SLC26A7 ENSG00000147606 341 SLC27A3 ENSG00000143554 342 SLC39A14 ENSG00000104635 343 SLC46A1 ENSG00000076351 344 SLC46A2 ENSG00000119457 345 SLC4A5 ENSG00000188687 346 SLC51B ENSG00000186198 347 SLC7A6OS ENSG00000103061 348 SLC7A8 ENSG00000092068 349 SNAI2 ENSG00000019549 350 SNX3 ENSG00000112335 351 SPATA9 ENSG00000145757 352 SPCS3 ENSG00000129128 353 SPTAN1 ENSG00000197694 354 SUMF2 ENSG00000129103 355 SUN5 ENSG00000167098 356 SUPT5H ENSG00000196235 357 SYT14 ENSG00000143469 358 SYT9 ENSG00000170743 359 TAF7 ENSG00000178913 360 TAZ ENSG00000102125 361 TBC1D14 ENSG00000132405 362 TBC1D31 ENSG00000156787 363 TEX33 ENSG00000185264 364 THOC2 ENSG00000125676 365 TMC4 ENSG00000167608 366 TMED4 ENSG00000158604 367 TMEM123 ENSG00000152558 368 TMEM176A ENSG00000002933 369 TMEM66 ENSG00000133872 370 TMX3 ENSG00000166479 371 TOM1L2 ENSG00000175662 372 TP53I3 ENSG00000115129 373 TPCN1 ENSG00000186815 374 TPD52 ENSG00000076554 375 TPRA1 ENSG00000163870 376 TRAPPC13 ENSG00000113597 377 TRMT11 ENSG00000066651 378 TRPM7 ENSG00000092439 379 TTLL12 ENSG00000100304 380 TYR ENSG00000077498 381 UBE2T ENSG00000077152 382 UBIAD1 ENSG00000120942 383 UBQLN2 ENSG00000188021 384 UBXN6 ENSG00000167671 385 UGGT2 ENSG00000102595 386 UHRF2 ENSG00000147854 387 UNC119B ENSG00000175970 388 USP39 ENSG00000168883 389 VCPKMT ENSG00000100483 390 VPS54 ENSG00000143952 391 VSTM2L ENSG00000132821 392 WBP5 ENSG00000185222 393 WDR43 ENSG00000163811 394 WDR45B ENSG00000141580 395 WDR88 ENSG00000166359 396 WHSC1 ENSG00000109685 397 XK ENSG00000047597 398 XPOT ENSG00000184575 399 YARS2 ENSG00000139131 400 YIPF3 ENSG00000137207 401 YPEL5 ENSG00000119801 402 ZCCHC14 ENSG00000140948 403 ZDHHC19 ENSG00000163958 404 ZIC3 ENSG00000156925 405 ZKSCAN3 ENSG00000189298 406 ZNF263 ENSG00000006194 407 ZNF30 ENSG00000168661 408 ZNF395 ENSG00000186918 409 ZNF571 ENSG00000180479 410 ZNF618 ENSG00000157657 411 ZNF665 ENSG00000197497 412 ZNF710 ENSG00000140548 413 ZNF831 ENSG00000124203 414 ZW10 ENSG00000086827 415 NR2E3 416 RP11-93B14.5 417 MAN1B1-AS1 418 SLC25A5-AS1 419 RP1-60O19.1 420 LINC00327 421 BZRAP1-AS1 422 ALKBH3-AS1 423 RP5-1024G6.5 424 LINC00536 425 LINC00311 426 LINC00466 427 PROSER2-AS1 428 SEPT8 429 LOC283070 430 AC105339.1 431 LOC388780 432 HCG18 433 CLEC4GP1 434 WT1-AS 435 SRD5A2 436 SCARNA2 437 STXBP5-AS1 Supplementary data S8A Adipocytes - Pathway analysis of consistently up- or downregulated transcripts between the co-twins, n=12/14 co-twins Downregulated in the heavier co-twins Ingenuity -log(p- Ratio Overlaps with No overlap with Molecules Canonical value) dataset dataset Pathways 1 Oxidative 1,2E01 2,14E-01 21/98 (21%) 77/98 (79%) ATP5G2,SDHB,NDUFB4, Phosphorylation NDUFA7,NDUFB5,COX8 A,ATP5L,NDUFB8,ATP5C 1,ATP5B,NDUFA6,UQCR C2,CYC1,NDUFA12,CYB5 A,UQCRC1,NDUFS3,ATP 5F1,NDUFAB1,COX4I1,N DUFA8

2 Mitochondrial 1,1E01 1,57E-01 25/159 (16%) 134/159 (84%) HSD17B10,SDHB,NDUFA Dysfunction 7,NDUFB5,COX8A,ATP5L ,NDUFB8,PARK7,NDUFA B1,ATP5F1,COX4I1,NDU FA8,ATP5G2,NDUFB4,G PX7,ATP5C1,ATP5B,NDU FA6,TXN2,UQCRC2,CYC1 ,NDUFA12,CYB5A,NDUF S3,UQCRC1

3 Fatty Acid β- 4,65E00 2,33E-01 7/30 (23%) 23/30 (77%) HSD17B10,ECHS1,SLC27 oxidation I A2,ECI2,ECI1,HADH,HSD 17B8 4 AMPK Signaling 3,56E00 8,47E-02 15/177 (8%) 162/177 (92%) PFKFB3,TSC1,ULK1,ACAC B,EEF2,PPP2R5D,PFKL,S LC2A4,ADRB3,EIF4EBP1, ADRB1,IRS2,ACACA,MLY CD,ADRB2 5 Glutaryl-CoA 3,5E00 3,33E-01 4/12 (33%) 8/12 (67%) HSD17B10,HADH,GCDH, Degradation HSD17B8 6 Clathrin-mediated 3,38E00 8,15E-02 15/184 (8%) 169/184 (92%) APOE,CSNK2A1,APOB,C Endocytosis HP1,VEGFA,SH3GL1,ARR B1,ARPC1A,IGF1,TF,CSN Signaling K2B,UBC,HGS,SH3KBP1, RBP4 7 TCA Cycle II 3,3E00 2,17E-01 5/23 (22%) 18/23 (78%) SDHB,IDH3G,SUCLG1,DL (Eukaryotic) ST,IDH3B 8 LXR/RXR Activation 3,04E00 9,17E-02 11/120 (9%) 109/120 (91%) APOE,FDFT1,ECHS1,APO B,TF,ACACA,ARG2,RXRA, HADH,AGT,RBP4

9 Granzyme A 2,87E00 2,35E-01 4/17 (24%) 13/17 (76%) H1FX,HMGB2,H1F0,APE Signaling X1 10 Tryptophan 2,59E00 2E-01 4/20 (20%) 16/20 (80%) HSD17B10,HADH,GCDH, Degradation III HSD17B8 (Eukaryotic) 11 Biotin-carboxyl 2,58E00 6,67E-01 2/3 (67%) 1/3 (33%) ACACB,ACACA Carrier Protein Assembly 12 Fatty Acid β- 2,58E00 6,67E-01 2/3 (67%) 1/3 (33%) ECI2,ECI1 oxidation III (Unsaturated, Odd Number) 13 Acetate 2,29E00 5E-01 2/4 (50%) 2/4 (50%) ACSS3,ACSS2 Conversion to Acetyl-CoA 14 Retinol 1,94E00 1,33E-01 4/30 (13%) 26/30 (87%) DHRS3,RBP7,PNPLA2,ES Biosynthesis D 15 Ethanol 1,94E00 1,33E-01 4/30 (13%) 26/30 (87%) HSD17B10,ACSS3,ACSS2 Degradation II ,ADH1B 16 GDP-mannose 1,91E00 3,33E-01 2/6 (33%) 4/6 (67%) GPI,PMM1 Biosynthesis 17 Valine Degradation 1,81E00 1,67E-01 3/18 (17%) 15/18 (83%) ECHS1,BCKDHA,ALDH6A I 1 18 Ethanol 1,75E00 1,58E-01 3/19 (16%) 16/19 (84%) ACSS3,ACSS2,GPX7 Degradation IV 19 Protein 1,73E00 5,58E-02 14/251 (6%) 237/251 (94%) UBE4B,UBE2M,HSPA1A/ Ubiquitination HSPA1B,UBE2R2,DNAJC 19,USP30,PSMC5,DNAJC Pathway 11,STUB1,HSPB11,CDC3 4,DNAJB1,UBC,DNAJC7

20 Phosphatidylethan 1,66E00 2,5E-01 2/8 (25%) 6/8 (75%) PCYT2,CHKA olamine Biosynthesis II 21 RAR Activation 1,61E00 5,88E-02 11/187 (6%) 176/187 (94%) VEGFA,STAT5A,DHRS3,C CNH,CSNK2A1,RBP7,CSN K2B,NRIP1,RXRA,PSMC5 ,RBP4 22 Glycolysis I 1,58E00 1,36E-01 3/22 (14%) 19/22 (86%) GPI,TPI1,PFKL

23 VDR/RXR 1,57E00 7,79E-02 6/77 (8%) 71/77 (92%) LRP5,CSNK2A1,SP1,CDK Activation N1B,RXRA,PSMC5 24 Oleate 1,56E00 2,22E-01 2/9 (22%) 7/9 (78%) CYB5A,ALDH6A1 Biosynthesis II (Animals) 25 Glutamine 1,53E00 1E00 1/1 (100%) 0/1 (0%) GLUL Biosynthesis I 26 Methylglyoxal 1,53E00 1E00 1/1 (100%) 0/1 (0%) LDHD Degradation VI 27 Sulfite Oxidation IV 1,53E00 1E00 1/1 (100%) 0/1 (0%) SUOX

28 Pentose Phosphate 1,47E00 2E-01 2/10 (20%) 8/10 (80%) TKT,PGLS Pathway

29 Estrogen- 1,46E00 8,2E-02 5/61 (8%) 56/61 (92%) HSD17B10,STAT5A,IGF1, Dependent Breast SP1,HSD17B8 Cancer Signaling 30 Hypoxia Signaling 1,41E00 7,94E-02 5/63 (8%) 58/63 (92%) VEGFA,UBE2M,UBE2R2, in the CDC34,SLC2A4 Cardiovascular System 31 Assembly of RNA 1,32E00 1,67E-01 2/12 (17%) 10/12 (83%) GTF3C5,SF3A1 Polymerase III Complex 32 BER pathway 1,32E00 1,67E-01 2/12 (17%) 10/12 (83%) APEX1,XRCC1

33 Cholesterol 1,26E00 1,54E-01 2/13 (15%) 11/13 (85%) FDFT1,TM7SF2 Biosynthesis I 34 Cholesterol 1,26E00 1,54E-01 2/13 (15%) 11/13 (85%) FDFT1,TM7SF2 Biosynthesis II (via 24,25- dihydrolanosterol)

35 Cholesterol 1,26E00 1,54E-01 2/13 (15%) 11/13 (85%) FDFT1,TM7SF2 Biosynthesis III (via Desmosterol)

36 Epoxysqualene 1,23E00 5E-01 1/2 (50%) 1/2 (50%) FDFT1 Biosynthesis 37 β-alanine 1,23E00 5E-01 1/2 (50%) 1/2 (50%) ALDH6A1 Degradation I 38 Lipoate 1,23E00 5E-01 1/2 (50%) 1/2 (50%) LIAS Biosynthesis and Incorporation II 39 Alanine 1,23E00 5E-01 1/2 (50%) 1/2 (50%) GPT2 Degradation III 40 Alanine 1,23E00 5E-01 1/2 (50%) 1/2 (50%) GPT2 Biosynthesis II 41 L-cysteine 1,23E00 5E-01 1/2 (50%) 1/2 (50%) MPST Degradation III 42 L-glutamine 1,23E00 5E-01 1/2 (50%) 1/2 (50%) GATB Biosynthesis II (tRNA-dependent)

43 Formaldehyde 1,23E00 5E-01 1/2 (50%) 1/2 (50%) ESD Oxidation II (Glutathione- dependent) 44 Glycine 1,23E00 5E-01 1/2 (50%) 1/2 (50%) SHMT1 Biosynthesis I 45 Isoleucine 1,2E00 1,43E-01 2/14 (14%) 12/14 (86%) HSD17B10,ECHS1 Degradation I 46 Colanic Acid 1,2E00 1,43E-01 2/14 (14%) 12/14 (86%) GPI,PMM1 Building Blocks Biosynthesis 47 Superpathway of 1,2E00 9,68E-02 3/31 (10%) 28/31 (90%) MGMT,PCCB,SUOX Methionine Degradation 48 Telomere 1,14E00 1,33E-01 2/15 (13%) 13/15 (87%) TERF2IP,PINX1 Extension by Telomerase 49 The Visual Cycle 1,14E00 1,33E-01 2/15 (13%) 13/15 (87%) DHRS3,RBP7

50 Oxidative Ethanol 1,14E00 1,33E-01 2/15 (13%) 13/15 (87%) ACSS3,ACSS2 Degradation III

51 Circadian Rhythm 1,13E00 9,09E-02 3/33 (9%) 30/33 (91%) CSNK1E,PER1,GRINA Signaling

52 IL-9 Signaling 1,1E00 8,82E-02 3/34 (9%) 31/34 (91%) STAT5A,CISH,IRS2

53 Estrogen Receptor 1,08E00 5,56E-02 7/126 (6%) 119/126 (94%) CCNH,POLR2C,PHB2,PCK Signaling 1,NRIP1,MED12,NR3C1

54 Diphthamide 1,06E00 3,33E-01 1/3 (33%) 2/3 (67%) EEF2 Biosynthesis 55 D-glucuronate 1,06E00 3,33E-01 1/3 (33%) 2/3 (67%) DCXR Degradation I 56 Thiosulfate 1,06E00 3,33E-01 1/3 (33%) 2/3 (67%) MPST Disproportionation III (Rhodanese)

57 Tyrosine 1,06E00 3,33E-01 1/3 (33%) 2/3 (67%) PCBD1 Biosynthesis IV 58 Glutathione Redox 1,05E00 1,18E-01 2/17 (12%) 15/17 (88%) GPX7,PRDX6 Reactions I

59 γ-linolenate 1,05E00 1,18E-01 2/17 (12%) 15/17 (88%) SLC27A2,CYB5A Biosynthesis II (Animals) 60 mTOR Signaling 1,03E00 4,97E-02 9/181 (5%) 172/181 (95%) VEGFA,TSC1,ULK1,EIF3H ,RPS20,PPP2R5D,PLD1,E IF3K,EIF4EBP1 61 Aryl Hydrocarbon 9,89E- 5,26E-02 7/133 (5%) 126/133 (95%) ALDH1L1,SP1,NRIP1,CD Receptor Signaling 01 KN1B,RXRA,ALDH6A1,M CM7

62 Retinoate 9,43E- 2,5E-01 1/4 (25%) 3/4 (75%) RBP7 Biosynthesis II 01 63 2-ketoglutarate 9,43E- 2,5E-01 1/4 (25%) 3/4 (75%) DLST Dehydrogenase 01 Complex 64 Branched-chain α- 9,43E- 2,5E-01 1/4 (25%) 3/4 (75%) BCKDHA keto acid 01 Dehydrogenase Complex 65 Eumelanin 9,43E- 2,5E-01 1/4 (25%) 3/4 (75%) DDT Biosynthesis 01 66 Methylmalonyl 9,43E- 2,5E-01 1/4 (25%) 3/4 (75%) PCCB Pathway 01 67 Arginine 9,43E- 2,5E-01 1/4 (25%) 3/4 (75%) ARG2 Degradation I 01 (Arginase Pathway)

68 Phenylalanine 9,43E- 2,5E-01 1/4 (25%) 3/4 (75%) PCBD1 Degradation I 01 (Aerobic) 69 Molybdenum 9,43E- 2,5E-01 1/4 (25%) 3/4 (75%) GPHN Cofactor 01 Biosynthesis 70 Regulation of eIF4 9,03E- 5E-02 7/140 (5%) 133/140 (95%) EIF2B4,EIF3H,RPS20,PPP and p70S6K 01 2R5D,MKNK1,EIF3K,EIF4 EBP1 Signaling 71 Huntington's 8,67E- 4,44E-02 10/225 (4%) 215/225 (96%) SDHB,POLR2C,IGF1,ATP Disease Signaling 01 5B,SP1,HSPA1A/HSPA1B ,GNA14,DNAJB1,UBC,G NG7 72 Creatine- 8,53E- 2E-01 1/5 (20%) 4/5 (80%) CKB phosphate 01 Biosynthesis 73 Pentose Phosphate 8,53E- 2E-01 1/5 (20%) 4/5 (80%) PGLS Pathway (Oxidative 01 Branch)

74 Pentose Phosphate 8,53E- 2E-01 1/5 (20%) 4/5 (80%) TKT Pathway (Non- 01 oxidative Branch)

75 2-oxobutanoate 8,53E- 2E-01 1/5 (20%) 4/5 (80%) PCCB Degradation I 01 76 dTMP De Novo 8,53E- 2E-01 1/5 (20%) 4/5 (80%) SHMT1 Biosynthesis 01 77 Folate 8,53E- 2E-01 1/5 (20%) 4/5 (80%) SHMT1 Polyglutamylation 01

78 NRF2-mediated 8,17E- 4,57E-02 8/175 (5%) 167/175 (95%) DNAJC19,DNAJA3,JUND, Oxidative Stress 01 CDC34,DNAJB1,CLPP,DN AJC7,DNAJC11 Response 79 GPCR-Mediated 8,08E- 5,71E-02 4/70 (6%) 66/70 (94%) ADRB1,GNA14,ADRB3,A Integration of 01 DRB2 Enteroendocrine Signaling Exemplified by an L Cell 80 nNOS Signaling in 8,05E- 6,52E-02 3/46 (7%) 43/46 (93%) CHP1,RASD1,GRINA Neurons 01 81 Adipogenesis 8,04E- 4,92E-02 6/122 (5%) 116/122 (95%) EBF1,CCNH,LPIN1,KDM1 pathway 01 A,FGFRL1,SLC2A4 82 Triacylglycerol 7,98E- 8,33E-02 2/24 (8%) 22/24 (92%) PNPLA2,PRDX6 Degradation 01 83 FXR/RXR Activation 7,81E- 4,84E-02 6/124 (5%) 118/124 (95%) APOE,APOB,TF,RXRA,AG 01 T,RBP4 84 Urea Cycle 7,8E-01 1,67E-01 1/6 (17%) 5/6 (83%) ARG2

85 Arginine 7,8E-01 1,67E-01 1/6 (17%) 5/6 (83%) ARG2 Degradation VI (Arginase 2 Pathway) 86 Zymosterol 7,8E-01 1,67E-01 1/6 (17%) 5/6 (83%) TM7SF2 Biosynthesis 87 Glycogen 7,8E-01 1,67E-01 1/6 (17%) 5/6 (83%) GYG2 Biosynthesis II (from UDP-D- Glucose) 88 Insulin Receptor 7,49E- 4,72E-02 6/127 (5%) 121/127 (95%) TSC1,EIF2B4,PPP1R3C,IR Signaling 01 S2,SLC2A4,EIF4EBP1 89 Antiproliferative 7,43E- 7,69E-02 2/26 (8%) 24/26 (92%) CDC34,CDKN1B Role of TOB in T 01 Cell Signaling 90 Glucocorticoid 7,36E- 4,07E-02 11/270 (4%) 259/270 (96%) STAT5A,CCNH,POLR2C,C Receptor Signaling 01 DKN1C,HSPA1A/HSPA1B ,CHP1,PCK1,NRIP1,NR3C 1,AGT,ADRB2 91 Amyloid Processing 7,3E-01 6E-02 3/50 (6%) 47/50 (94%) CSNK1E,CSNK2A1,CSNK2 B 92 Superpathway of 7,19E- 1,43E-01 1/7 (14%) 6/7 (86%) SHMT1 Serine and Glycine 01 Biosynthesis I

93 Phosphatidylcholin 7,19E- 1,43E-01 1/7 (14%) 6/7 (86%) CHKA e Biosynthesis I 01

94 Cell Cycle Control 7,18E- 7,41E-02 2/27 (7%) 25/27 (93%) MCM6,MCM7 of Chromosomal 01 Replication

95 Superpathway of 7,18E- 7,41E-02 2/27 (7%) 25/27 (93%) FDFT1,TM7SF2 Cholesterol 01 Biosynthesis 96 Cyclins and Cell 7,06E- 5,19E-02 4/77 (5%) 73/77 (95%) CCNH,PPP2R5D,CDKN2C Cycle Regulation 01 ,CDKN1B 97 Cardiac β- 6,97E- 4,55E-02 6/132 (5%) 126/132 (95%) ADRB1,PPP2R5D,PPP1R adrenergic 01 3C,AKAP9,APEX1,GNG7 Signaling 98 Gαs Signaling 6,8E-01 4,72E-02 5/106 (5%) 101/106 (95%) ADD3,ADRB1,ADRB3,GN G7,ADRB2 99 IL-2 Signaling 6,79E- 5,66E-02 3/53 (6%) 50/53 (94%) STAT5A,CSNK2A1,CSNK2 01 B 100 Role of Tissue 6,69E- 4,67E-02 5/107 (5%) 102/107 (95%) VEGFA,STAT5A,ARRB1,E Factor in Cancer 01 GR1,GNA14 101 Sucrose 6,68E- 1,25E-01 1/8 (13%) 7/8 (88%) TPI1 Degradation V 01 (Mammalian) 102 Citrulline 6,68E- 1,25E-01 1/8 (13%) 7/8 (88%) ARG2 Biosynthesis 01 103 Superoxide 6,68E- 1,25E-01 1/8 (13%) 7/8 (88%) GPX7 Radicals 01 Degradation 104 Wnt/β-catenin 6,53E- 4,24E-02 7/165 (4%) 158/165 (96%) CSNK1E,LRP5,CSNK2A1, Signaling 01 PPP2R5D,TCF7L1,CSNK2 B,UBC 105 Retinoate 6,49E- 6,67E-02 2/30 (7%) 28/30 (93%) DHRS3,RBP7 Biosynthesis I 01 106 Thrombopoietin 6,48E- 5,45E-02 3/55 (5%) 52/55 (95%) GAB2,STAT5A,IRS2 Signaling 01 107 Androgen Signaling 6,37E- 4,55E-02 5/110 (5%) 105/110 (95%) CCNH,POLR2C,GNA14,D 01 NAJB1,GNG7 108 ErbB2-ErbB3 6,33E- 5,36E-02 3/56 (5%) 53/56 (95%) STAT5A,SP1,CDKN1B Signaling 01 109 Glutamate 6,33E- 5,36E-02 3/56 (5%) 53/56 (95%) GLUL,GNG7,GRINA Receptor Signaling 01

110 Assembly of RNA 6,23E- 1,11E-01 1/9 (11%) 8/9 (89%) POLR1D Polymerase I 01 Complex 111 Glycogen 6,23E- 1,11E-01 1/9 (11%) 8/9 (89%) PYGM Degradation II 01 112 UDP-N-acetyl-D- 6,23E- 1,11E-01 1/9 (11%) 8/9 (89%) GPI galactosamine 01 Biosynthesis II 113 Folate 6,23E- 1,11E-01 1/9 (11%) 8/9 (89%) SHMT1 Transformations I 01

114 EIF2 Signaling 6,2E-01 4,14E-02 7/169 (4%) 162/169 (96%) RPL14,RPL22,EIF2B4,EIF 3H,RPS20,UBA52,EIF3K

115 Role of JAK2 in 6,08E- 6,25E-02 2/32 (6%) 30/32 (94%) STAT5A,IRS2 Hormone-like 01 Cytokine Signaling

116 TR/RXR Activation 6,07E- 4,71E-02 4/85 (5%) 81/85 (95%) ADRB1,ACACA,PCK1,RXR 01 A 117 Triacylglycerol 5,89E- 6,06E-02 2/33 (6%) 31/33 (94%) LPIN1,DGAT1 Biosynthesis 01 118 Noradrenaline and 5,89E- 6,06E-02 2/33 (6%) 31/33 (94%) HSD17B10,ADH1B Adrenaline 01 Degradation 119 Embryonic Stem 5,83E- 1E-01 1/10 (10%) 9/10 (90%) MESP1 Cell Differentiation 01 into Cardiac Lineages

120 NAD 5,83E- 1E-01 1/10 (10%) 9/10 (90%) ACP6 Phosphorylation 01 and Dephosphorylation

121 Glycine Betaine 5,83E- 1E-01 1/10 (10%) 9/10 (90%) SHMT1 Degradation 01 122 Antiproliferative 5,77E- 5E-02 3/60 (5%) 57/60 (95%) NPR1,CDKN1B,GNG7 Role of 01 Somatostatin Receptor 2 123 PTEN Signaling 5,69E- 4,27E-02 5/117 (4%) 112/117 (96%) CSNK2A1,FGFRL1,CSNK2 01 B,CDKN1B,MAGI2 124 Estrogen 5,53E- 5,71E-02 2/35 (6%) 33/35 (94%) HSD17B10,HSD17B8 Biosynthesis 01 125 Nucleotide Excision 5,53E- 5,71E-02 2/35 (6%) 33/35 (94%) CCNH,POLR2C Repair Pathway 01

126 Glycogen 5,48E- 9,09E-02 1/11 (9%) 10/11 (91%) PYGM Degradation III 01 127 Purine Nucleotides 5,48E- 9,09E-02 1/11 (9%) 10/11 (91%) ADSSL1 De Novo 01 Biosynthesis II

128 Production of 5,44E- 3,91E-02 7/179 (4%) 172/179 (96%) APOE,APOB,PPP2R5D,P Nitric Oxide and 01 PP1R3C,IFNGR2,ARG2,R BP4 Reactive Oxygen Species in Macrophages 129 PI3K/AKT Signaling 5,42E- 4,17E-02 5/120 (4%) 115/120 (96%) GAB2,TSC1,PPP2R5D,CD 01 KN1B,EIF4EBP1 130 Aldosterone 5,38E- 4E-02 6/150 (4%) 144/150 (96%) DNAJC19,HSPA1A/HSPA Signaling in 01 1B,HSPB11,DNAJB1,DNA JC7,DNAJC11 Epithelial Cells 131 Antioxidant Action 5,32E- 4,35E-02 4/92 (4%) 88/92 (96%) STAT5A,SLC2A4,PLD1,PR of Vitamin C 01 DX6

132 Remodeling of 5,27E- 4,69E-02 3/64 (5%) 61/64 (95%) ARPC1A,HGS,MAPRE2 Epithelial Adherens 01 Junctions 133 Protein Kinase A 5,17E- 3,53E-02 13/368 (4%) 355/368 (96%) PTPRG,PYGM,ADD3,H1F Signaling 01 X,PPP1R3C,CHP1,AKAP9 ,TIMM50,H1F0,PTPN3,T CF7L1,APEX1,GNG7

134 Cleavage and 5,17E- 8,33E-02 1/12 (8%) 11/12 (92%) WDR33 Polyadenylation of 01 Pre-mRNA 135 Ubiquinol-10 5,17E- 8,33E-02 1/12 (8%) 11/12 (92%) BCKDHA Biosynthesis 01 (Eukaryotic) 136 tRNA Charging 5,04E- 5,26E-02 2/38 (5%) 36/38 (95%) VARS2,KARS 01 137 Nitric Oxide 5,03E- 4,21E-02 4/95 (4%) 91/95 (96%) VEGFA,ADRB1,ARG2,AD Signaling in the 01 RB3 Cardiovascular System 138 IGF-1 Signaling 4,94E- 4,17E-02 4/96 (4%) 92/96 (96%) CSNK2A1,IGF1,IRS2,CSN 01 K2B 139 Thyroid Cancer 4,89E- 5,13E-02 2/39 (5%) 37/39 (95%) TCF7L1,RXRA Signaling 01 140 Cardiac 4,89E- 3,67E-02 8/218 (4%) 210/218 (96%) EIF2B4,ADRB1,IGF1,CHP Hypertrophy 01 1,GNA14,ADRB3,GNG7, ADRB2 Signaling 141 Fatty Acid 4,88E- 7,69E-02 1/13 (8%) 12/13 (92%) SLC27A2 Activation 01 142 Choline 4,88E- 7,69E-02 1/13 (8%) 12/13 (92%) PLD1 Biosynthesis III 01 143 γ-glutamyl Cycle 4,88E- 7,69E-02 1/13 (8%) 12/13 (92%) OPLAH 01 144 Amyotrophic 4,85E- 4,12E-02 4/97 (4%) 93/97 (96%) VEGFA,IGF1,GLUL,GRIN Lateral Sclerosis 01 A Signaling 145 Neuroprotective 4,75E- 5E-02 2/40 (5%) 38/40 (95%) ECE1,AGT Role of THOP1 in 01 Alzheimer's Disease 146 Growth Hormone 4,71E- 4,35E-02 3/69 (4%) 66/69 (96%) STAT5A,IGF1,SLC2A4 Signaling 01

147 DNA Double- 4,62E- 7,14E-02 1/14 (7%) 13/14 (93%) XRCC1 Strand Break 01 Repair by Non- Homologous End Joining 148 Superpathway of 4,62E- 7,14E-02 1/14 (7%) 13/14 (93%) ARG2 Citrulline 01 Metabolism 149 Dermatan Sulfate 4,62E- 7,14E-02 1/14 (7%) 13/14 (93%) FGFRL1 Degradation 01 (Metazoa)

150 Phenylalanine 4,62E- 7,14E-02 1/14 (7%) 13/14 (93%) SLC27A2 Degradation IV 01 (Mammalian, via Side Chain) 151 Vitamin-C 4,62E- 7,14E-02 1/14 (7%) 13/14 (93%) SLC2A4 Transport 01 152 IL-12 Signaling and 4,54E- 3,82E-02 5/131 (4%) 126/131 (96%) JMJD6,APOE,APOB,RXR Production in 01 A,RBP4 Macrophages 153 IL-3 Signaling 4,5E-01 4,23E-02 3/71 (4%) 68/71 (96%) GAB2,STAT5A,CHP1

154 FLT3 Signaling in 4,5E-01 4,23E-02 3/71 (4%) 68/71 (96%) GAB2,STAT5A,EIF4EBP1 Hematopoietic Progenitor Cells 155 Relaxin Signaling 4,47E- 3,79E-02 5/132 (4%) 127/132 (96%) VEGFA,NPR1,GNA14,AP 01 EX1,GNG7 156 Synaptic Long 4,4E-01 3,76E-02 5/133 (4%) 128/133 (96%) IGF1,PPP2R5D,NPR1,GN Term Depression A14,PRDX6 157 Parkinson's 4,38E- 6,67E-02 1/15 (7%) 14/15 (93%) PARK7 Signaling 01 158 iNOS Signaling 4,34E- 4,65E-02 2/43 (5%) 41/43 (95%) IFNGR2,IRAK3 01 159 Prolactin Signaling 4,3E-01 4,11E-02 3/73 (4%) 70/73 (96%) STAT5A,SP1,NR3C1

160 Ephrin B Signaling 4,3E-01 4,11E-02 3/73 (4%) 70/73 (96%) RGS3,GNA14,GNG7

161 Methionine 4,16E- 6,25E-02 1/16 (6%) 15/16 (94%) MGMT Degradation I (to 01 Homocysteine) 162 Role of Oct4 in 4,1E-01 4,44E-02 2/45 (4%) 43/45 (96%) KDM5B,PPP1R8 Mammalian Embryonic Stem Cell Pluripotency

163 Acute Myeloid 4,03E- 3,95E-02 3/76 (4%) 73/76 (96%) STAT5A,TCF7L1,EIF4EBP Leukemia Signaling 01 1

164 Nur77 Signaling in 3,98E- 4,35E-02 2/46 (4%) 44/46 (96%) CHP1,RXRA T Lymphocytes 01

165 Mitochondrial L- 3,96E- 5,88E-02 1/17 (6%) 16/17 (94%) SLC27A2 carnitine Shuttle 01 Pathway 166 Dopamine 3,94E- 3,9E-02 3/77 (4%) 74/77 (96%) PPP2R5D,PPP1R3C,PCB Receptor Signaling 01 D1 167 Ephrin Receptor 3,91E- 3,49E-02 6/172 (3%) 166/172 (97%) VEGFA,RGS3,ARPC1A,G Signaling 01 NA14,GNG7,GRINA 168 Cysteine 3,77E- 5,56E-02 1/18 (6%) 17/18 (94%) MGMT Biosynthesis III 01 (mammalia) 169 Systemic Lupus 3,64E- 3,39E-02 6/177 (3%) 171/177 (97%) LSM6,SNRPA,SNRNP27, Erythematosus 01 PRPF8,CD72,SNRNP70 Signaling 170 Assembly of RNA 3,55E- 4E-02 2/50 (4%) 48/50 (96%) CCNH,POLR2C Polymerase II 01 Complex 171 Serotonin 3,45E- 3,92E-02 2/51 (4%) 49/51 (96%) HSD17B10,ADH1B Degradation 01 172 Synaptic Long 3,42E- 3,45E-02 4/116 (3%) 112/116 (97%) PPP1R3C,CHP1,GNA14, Term Potentiation 01 GRINA

173 Gap Junction 3,39E- 3,36E-02 5/149 (3%) 144/149 (97%) CSNK1E,ADRB1,SP1,NPR Signaling 01 1,SGSM3 174 Xenobiotic 3,37E- 3,23E-02 8/248 (3%) 240/248 (97%) ALDH1L1,PPP2R5D,MG Metabolism 01 MT,NRIP1,RXRA,ALDH6 A1,DNAJC7,ESD Signaling 175 Phospholipases 3,36E- 3,85E-02 2/52 (4%) 50/52 (96%) PLD1,PRDX6 01 176 HIPPO signaling 3,31E- 3,53E-02 3/85 (4%) 82/85 (96%) CSNK1E,PPP2R5D,PPP1R 01 3C 177 p70S6K Signaling 3,29E- 3,39E-02 4/118 (3%) 114/118 (97%) EEF2,PPP2R5D,PLD1,AG 01 T 178 Atherosclerosis 3,29E- 3,39E-02 4/118 (3%) 114/118 (97%) APOE,APOB,PRDX6,RBP Signaling 01 4 179 NAD Salvage 3,28E- 4,76E-02 1/21 (5%) 20/21 (95%) ACP6 Pathway II 01 180 D-myo-inositol 3,17E- 3,33E-02 4/120 (3%) 116/120 (97%) CA3,PPP1R8,PPP2R5D,I (1,4,5,6)- 01 GBP1 Tetrakisphosphate Biosynthesis 181 D-myo-inositol 3,17E- 3,33E-02 4/120 (3%) 116/120 (97%) CA3,PPP1R8,PPP2R5D,I (3,4,5,6)- 01 GBP1 tetrakisphosphate Biosynthesis 182 Breast Cancer 3,1E-01 3,19E-02 6/188 (3%) 182/188 (97%) ARHGEF4,PPP2R5D,ARH Regulation by GEF7,PPP1R3C,CDKN1B, GNG7 Stathmin1 183 EGF Signaling 3,01E- 3,57E-02 2/56 (4%) 54/56 (96%) CSNK2A1,CSNK2B 01 184 Gluconeogenesis I 3E-01 4,35E-02 1/23 (4%) 22/23 (96%) GPI

185 Dopamine- 2,98E- 3,18E-02 5/157 (3%) 152/157 (97%) CSNK1E,PPP2R5D,PPP1R DARPP32 Feedback 01 3C,CHP1,GRINA in cAMP Signaling 186 PPAR Signaling 2,97E- 3,33E-02 3/90 (3%) 87/90 (97%) STAT5A,NRIP1,RXRA 01 187 IL-1 Signaling 2,91E- 3,3E-02 3/91 (3%) 88/91 (97%) GNA14,IRAK3,GNG7 01 188 IL-22 Signaling 2,87E- 4,17E-02 1/24 (4%) 23/24 (96%) STAT5A 01 189 Role of JAK1, JAK2 2,87E- 4,17E-02 1/24 (4%) 23/24 (96%) IFNGR2 and TYK2 in 01 Interferon Signaling 190 Estrogen-mediated 2,87E- 4,17E-02 1/24 (4%) 23/24 (96%) CDKN1B S-phase Entry 01

191 Fcγ Receptor- 2,85E- 3,26E-02 3/92 (3%) 89/92 (97%) GAB2,ARPC1A,PLD1 mediated 01 Phagocytosis in Macrophages and Monocytes 192 Chronic Myeloid 2,85E- 3,26E-02 3/92 (3%) 89/92 (97%) GAB2,STAT5A,CDKN1B Leukemia Signaling 01

193 Role of JAK family 2,75E- 4E-02 1/25 (4%) 24/25 (96%) STAT5A kinases in IL-6-type 01 Cytokine Signaling

194 Role of JAK1 and 2,7E-01 3,33E-02 2/60 (3%) 58/60 (97%) STAT5A,IRS2 JAK3 in γc Cytokine Signaling

195 Telomerase 2,61E- 3,12E-02 3/96 (3%) 93/96 (97%) SP1,PPP2R5D,TERF2IP Signaling 01 196 Acute Phase 2,57E- 3,01E-02 5/166 (3%) 161/166 (97%) RBP7,TF,NR3C1,AGT,RB Response Signaling 01 P4

197 PXR/RXR 2,56E- 3,23E-02 2/62 (3%) 60/62 (97%) RXRA,NR3C1 Activation 01 198 T Helper Cell 2,56E- 3,23E-02 2/62 (3%) 60/62 (97%) IFNGR2,BCL6 Differentiation 01 199 CDK5 Signaling 2,5E-01 3,06E-02 3/98 (3%) 95/98 (97%) PPP2R5D,PPP1R3C,EGR 1 200 Cell Cycle: G1/S 2,49E- 3,17E-02 2/63 (3%) 61/63 (97%) CDKN2C,CDKN1B Checkpoint 01 Regulation 201 HIF1α Signaling 2,4E-01 3E-02 3/100 (3%) 97/100 (97%) VEGFA,SLC2A4,APEX1

202 Role of 2,33E- 3,45E-02 1/29 (3%) 28/29 (97%) SF3A1 p14/p19ARF in 01 Tumor Suppression 203 Sonic Hedgehog 2,33E- 3,45E-02 1/29 (3%) 28/29 (97%) GLIS1 Signaling 01 204 GABA Receptor 2,3E-01 3,03E-02 2/66 (3%) 64/66 (97%) GPHN,UBC Signaling 205 G Protein Signaling 2,16E- 3,23E-02 1/31 (3%) 30/31 (97%) GNG7 Mediated by Tubby 01

206 MIF-mediated 2,16E- 3,23E-02 1/31 (3%) 30/31 (97%) NR3C1 Glucocorticoid 01 Regulation 207 Inhibition of 2,07E- 3,12E-02 1/32 (3%) 31/32 (97%) VEGFA Angiogenesis by 01 TSP1 208 Stearate 2E-01 3,03E-02 1/33 (3%) 32/33 (97%) SLC27A2 Biosynthesis I (Animals)

Upregulated in the heavier co- Ingenuity -log(p- Ratio Overlaps with No overlap with Molecules Canonical value) dataset dataset Pathways 1 IL-10 Signaling 7,83E00 1,91E-01 13/68 (19%) 55/68 (81%) CCR1,IL1A,MAPK1,IL10,S TAT3,FCGR2B,HMOX1,IL 1RN,IL10RA,CD14,IL1B, MAP4K4,TNF 2 Granulocyte 7,54E00 1,19E-01 19/160 (12%) 141/160 (88%) CXCL8,SELE,IL1A,C5AR1, Adhesion and CXCL16,CCL4,ITGAM,CCL 13,CCL2,IL1RN,EZR,IL1B, Diapedesis CXCL1,CCL18,TNFRSF1B, CXCL2,TNF,TNFRSF11B, MSN 3 IL-8 Signaling 7,3E00 1,09E-01 20/183 (11%) 163/183 (89%) CXCL8,ANGPT2,MAPK1, GNG2,RAC1,KRAS,IQGA P1,GNB1,GNB4,HMOX1, RHOQ,ITGAM,CYBB,ITG AV,CXCL1,MAP4K4,MAP 2K1,GNG12,IRAK4,ITGB5

4 Role of Pattern 6,47E00 1,27E-01 15/118 (13%) 103/118 (87%) CXCL8,IL1A,NLRP3,C5AR Recognition 1,MAPK1,IL10,C1QC,C1 QA,C1QB,EIF2S1,IFIH1,D Receptors in DX58,IL1B,TNF,C3AR1 Recognition of Bacteria and Viruses 5 HMGB1 Signaling 6,47E00 1,27E-01 15/118 (13%) 103/118 (87%) CXCL8,SELE,IL1A,MAPK1 ,RAC1,KRAS,KAT2B,RHO Q,CCL2,IL1B,TNFRSF1B,S ERPINE1,TNF,MAP2K1,T NFRSF11B 6 Differential 5,93E00 3,04E-01 7/23 (30%) 16/23 (70%) IL1A,CCL4,CCL2,IL10,IL1 Regulation of B,CXCL1,TNF Cytokine Production in Intestinal Epithelial Cells by IL-17A and IL-17F

7 Differential 5,41E00 3,33E-01 6/18 (33%) 12/18 (67%) CCL4,CCL2,IL10,IL1B,CXC Regulation of L1,TNF Cytokine Production in Macrophages and T Helper Cells by IL- 17A and IL-17F

8 Glucocorticoid 5,18E00 7,78E-02 21/270 (8%) 249/270 (92%) CXCL8,SELE,YWHAH,MA Receptor Signaling PK1,SGK1,IL10,RAC1,PO LR2K,KRAS,STAT3,CD163 ,CCL13,KAT2B,CCL2,IL1R N,ANXA1,GTF2H5,IL1B,S ERPINE1,TNF,MAP2K1

9 Role of 5,1E00 1,95E-01 8/41 (20%) 33/41 (80%) CCR1,CXCL8,IL1A,CCL4,C Hypercytokinemia/ CL2,IL1RN,IL1B,TNF hyperchemokinemi a in the Pathogenesis of Influenza 10 Role of IL-17F in 5,1E00 1,95E-01 8/41 (20%) 33/41 (80%) CXCL8,CCL4,CCL2,MAPK Allergic 1,RPS6KA3,IL1B,CXCL1, MAP2K1 Inflammatory Airway Diseases 11 Agranulocyte 5,1E00 9,41E-02 16/170 (9%) 154/170 (91%) CXCL8,SELE,IL1A,C5AR1, Adhesion and CXCL16,CCL13,CCL4,CCL 2,IL1RN,EZR,IL1B,CXCL1, Diapedesis CXCL2,CCL18,TNF,MSN

12 IL-6 Signaling 5,07E00 1,12E-01 13/116 (11%) 103/116 (89%) CXCL8,IL1A,MAPK1,IL1R N,IL1B,CD14,KRAS,STAT 3,TNFRSF1B,MAP4K4,TN F,MAP2K1,TNFRSF11B

13 Ephrin Receptor 5,04E00 9,3E-02 16/172 (9%) 156/172 (91%) MAPK1,PDGFA,ARPC5,G Signaling NG2,RAC1,EPHA4,CRK,K RAS,STAT3,GNB1,GNB4, WIPF1,ACTR3,MAP4K4, MAP2K1,GNG12

14 TREM1 Signaling 4,96E00 1,43E-01 10/70 (14%) 60/70 (86%) CXCL8,NLRP3,CCL2,MAP K1,IL10,TYROBP,IL1B,ST AT3,FCGR2B,TNF 15 PPAR Signaling 4,73E00 1,22E-01 11/90 (12%) 79/90 (88%) IL1A,MAPK1,PDGFA,IL1R N,IL1B,KRAS,TNFRSF1B, MAP2K1,TNF,MAP4K4,T NFRSF11B 16 Role of Tissue 4,73E00 1,12E-01 12/107 (11%) 95/107 (89%) CXCL8,MAPK1,ITGAV,HC Factor in Cancer K,RAC1,RPS6KA3,LYN,PL AUR,IL1B,KRAS,CXCL1,IT GB5 17 Acute Phase 4,61E00 9,04E-02 15/166 (9%) 151/166 (91%) IL1A,MAPK1,KRAS,STAT Response Signaling 3,HMOX1,HP,IL1RN,IL1B ,OSMR,TNFRSF1B,SERPI NE1,TNF,SOCS5,MAP2K 1,TNFRSF11B 18 Actin Cytoskeleton 4,55E00 8,13E-02 17/209 (8%) 192/209 (92%) MAPK1,F2R,PDGFA,ARP Signaling C5,RAC1,CRK,KRAS,IQGA P1,IQGAP2,ACTR3,PPP1 R12A,EZR,CD14,MAP2K1 ,PIP4K2A,GNG12,MSN

19 Signaling by Rho 4,53E00 7,79E-02 18/231 (8%) 213/231 (92%) MAPK1,ARPC5,GNG2,RA Family GTPases C1,IQGAP1,CLIP1,GNB1, GNB4,WIPF1,RHOQ,ACT R3,PPP1R12A,EZR,CYBB, MAP2K1,PIP4K2A,GNG1 2,MSN 20 Integrin Signaling 4,39E00 8,25E-02 16/194 (8%) 178/194 (92%) RAP2A,MAPK1,ARPC5,R AC1,CRK,KRAS,WIPF1,AC TR3,ITGAM,RHOQ,PPP1 R12A,ARF4,ITGAV,MAP2 K1,CTTN,ITGB5

21 fMLP Signaling in 4,03E00 1,03E-01 11/107 (10%) 96/107 (90%) GNB1,GNB4,ACTR3,MAP Neutrophils K1,ARPC5,GNG2,RAC1,C YBB,KRAS,MAP2K1,GNG 12 22 Toll-like Receptor 4E00 1,23E-01 9/73 (12%) 64/73 (88%) IL1A,MAPK1,IL1RN,TNFA Signaling IP3,CD14,IL1B,TNF,MAP 4K4,IRAK4

23 Fcγ Receptor- 3,92E00 1,09E-01 10/92 (11%) 82/92 (89%) MYO5A,HMOX1,ACTR3, mediated MAPK1,EZR,ARPC5,HCK, RAC1,LYN,CRK Phagocytosis in Macrophages and Monocytes 24 GM-CSF Signaling 3,81E00 1,31E-01 8/61 (13%) 53/61 (87%) CSF2RB,MAPK1,HCK,LYN ,KRAS,STAT3,BCL2A1,M AP2K1 25 Phospholipase C 3,74E00 7,27E-02 16/220 (7%) 204/220 (93%) MAPK1,GNG2,RAC1,RPS Signaling 6KA3,KRAS,FCGR2B,GNB 1,GNB4,HMOX1,PLA2G4 A,RHOQ,PPP1R12A,FCE R1G,LYN,MAP2K1,GNG1 2 26 Remodeling of 3,66E00 1,25E-01 8/64 (13%) 56/64 (88%) ACTR3,ARPC5,TUBB2A,E Epithelial Adherens XOC2,RAB7A,IQGAP1,CL IP1,TUBB2B Junctions

27 Hepatic Fibrosis / 3,62E00 7,73E-02 14/181 (8%) 167/181 (92%) CXCL8,IL1A,COL5A2,CCL Hepatic Stellate 2,EDNRB,PDGFA,IL10,IL1 0RA,CD14,IL1B,SERPINE Cell Activation 1,TNFRSF1B,TNF,TNFRSF 11B 28 Complement 3,56E00 1,67E-01 6/36 (17%) 30/36 (83%) ITGAM,C5AR1,C1QC,C1 System QA,C1QB,C3AR1 29 Cdc42 Signaling 3,55E00 9,09E-02 11/121 (9%) 110/121 (91%) IQGAP2,WIPF1,ACTR3,M APK1,PPP1R12A,ARPC5, EXOC2,FCER1G,EXOC6,I QGAP1,CLIP1 30 Rac Signaling 3,51E00 9,71E-02 10/103 (10%) 93/103 (90%) IQGAP2,ACTR3,MAPK1, ARPC5,RAC1,CYBB,KRAS, IQGAP1,PIP4K2A,MAP2K 1 31 Sphingosine and 3,5E00 5E-01 3/6 (50%) 3/6 (50%) NAAA,SGPP1,ASAH1 Sphingosine-1- phosphate Metabolism 32 Role of 3,43E00 6,38E-02 18/282 (6%) 264/282 (94%) CXCL8,IL1A,SELE,C5AR1, Macrophages, MAPK1,IL10,PDGFA,RAC 1,KRAS,STAT3,CCL2,IL1R Fibroblasts and N,IL1B,TNFRSF1B,TNF,M Endothelial Cells in AP2K1,IRAK4,TNFRSF11 Rheumatoid B Arthritis 33 Communication 3,31E00 1,11E-01 8/72 (11%) 64/72 (89%) CXCL8,IL1A,CCL4,IL10,IL between Innate 1RN,FCER1G,IL1B,TNF and Adaptive Immune Cells 34 Actin Nucleation 3,27E00 1,25E-01 7/56 (13%) 49/56 (88%) WIPF1,ACTR3,RHOQ,PP by ARP-WASP P1R12A,ARPC5,RAC1,KR AS Complex 35 CCR3 Signaling in 3,25E00 9,01E-02 10/111 (9%) 101/111 (91%) GNB1,PLA2G4A,GNB4,M Eosinophils APK1,PPP1R12A,GNG2,R AC1,KRAS,MAP2K1,GNG 12 36 Glioma 3,22E00 1,23E-01 7/57 (12%) 50/57 (88%) RHOQ,F2R,MAPK1,ITGA Invasiveness V,PLAUR,KRAS,ITGB5 Signaling 37 Antiproliferative 3,08E00 1,17E-01 7/60 (12%) 53/60 (88%) GNB1,GNB4,MAPK1,GN Role of G2,KRAS,MAP2K1,GNG1 2 Somatostatin Receptor 2 38 Atherosclerosis 3,04E00 8,47E-02 10/118 (8%) 108/118 (92%) CXCL8,PLA2G4A,SELE,IL Signaling 1A,CCL2,PDGFA,IL1RN,IL 1B,TNF,CLU 39 Cholecystokinin/Ga 3,01E00 9,09E-02 9/99 (9%) 90/99 (91%) IL1A,RHOQ,MAPK1,IL1R strin-mediated N,IL1B,KRAS,EPHA4,MA P2K1,TNF Signaling

40 T Helper Cell 3E00 1,13E-01 7/62 (11%) 55/62 (89%) IL10,IL10RA,FCER1G,STA Differentiation T3,TNFRSF1B,TNF,TNFRS F11B 41 CCR5 Signaling in 2,96E00 1,11E-01 7/63 (11%) 56/63 (89%) GNB1,GNB4,CCL4,MAPK Macrophages 1,GNG2,FCER1G,GNG12 42 NF-κB Signaling 2,95E00 7,27E-02 12/165 (7%) 153/165 (93%) IL1A,IL1RN,PELI1,FCER1 G,TNFAIP3,IL1B,KRAS,T NFRSF1B,TNF,MAP4K4,I RAK4,TNFRSF11B 43 Breast Cancer 2,94E00 6,91E-02 13/188 (7%) 175/188 (93%) GNB1,GNB4,PPP1R12A, Regulation by MAPK1,TUBB2A,GNG2,R AC1,PPP2R5C,UHMK1,K Stathmin1 RAS,MAP2K1,GNG12,TU BB2B 44 RhoGDI Signaling 2,79E00 6,98E-02 12/172 (7%) 160/172 (93%) GNB1,GNB4,ACTR3,RHO Q,PPP1R12A,EZR,ARPC5 ,GNG2,RAC1,PIP4K2A,G NG12,MSN 45 Oncostatin M 2,79E00 1,47E-01 5/34 (15%) 29/34 (85%) MAPK1,OSMR,KRAS,STA Signaling T3,MAP2K1 46 Tec Kinase 2,77E00 7,33E-02 11/150 (7%) 139/150 (93%) GNB1,GNB4,RHOQ,GNG Signaling 2,HCK,FCER1G,LYN,STAT 3,TNFRSF10A,TNF,GNG1 2 47 Chemokine 2,76E00 1,03E-01 7/68 (10%) 61/68 (90%) CCL13,CCL4,CCL2,MAPK Signaling 1,PPP1R12A,KRAS,MAP2 K1 48 CXCR4 Signaling 2,75E00 7,28E-02 11/151 (7%) 140/151 (93%) GNB1,GNB4,RHOQ,MAP K1,GNG2,RAC1,LYN,CRK, KRAS,MAP2K1,GNG12

49 Coagulation 2,73E00 1,43E-01 5/35 (14%) 30/35 (86%) F2R,PLAUR,F13A1,THBD System ,SERPINE1 50 Apoptosis Signaling 2,73E00 9,09E-02 8/88 (9%) 80/88 (91%) MAPK1,BID,KRAS,TNFRS F1B,BCL2A1,MAP2K1,TN F,MAP4K4 51 NRF2-mediated 2,73E00 6,86E-02 12/175 (7%) 163/175 (93%) HMOX1,MAPK1,DNAJB4 Oxidative Stress ,PRDX1,ABCC1,NQO1,HS PB8,KRAS,DNAJB6,MAP Response 2K1,TXNRD1,FTH1

52 SAPK/JNK Signaling 2,7E00 8,99E-02 8/89 (9%) 81/89 (91%) MAP4K3,GNB1,GNG2,R AC1,FCER1G,CRK,KRAS, MAP4K4 53 Role of Cytokines 2,69E00 1,15E-01 6/52 (12%) 46/52 (88%) CXCL8,IL1A,IL10,IL1RN,IL in Mediating 1B,TNF Communication between Immune Cells

54 Aryl Hydrocarbon 2,65E00 7,52E-02 10/133 (8%) 123/133 (92%) IL1A,NCOA7,TFDP1,MAP Receptor Signaling K1,ALDH1A3,NQO1,IL1B ,ATR,TNF,AHR

55 Production of 2,65E00 6,7E-02 12/179 (7%) 167/179 (93%) RHOQ,MAPK1,PPP1R12 Nitric Oxide and A,RAC1,CYBB,PPP2R5C, NCF4,TNFRSF1B,MAP2K Reactive Oxygen 1,TNF,CLU,TNFRSF11B Species in Macrophages 56 phagosome 2,58E00 7,89E-02 9/114 (8%) 105/114 (92%) NSF,PRDX1,TUBB2A,CYB maturation B,NAPG,RAB7A,ATP6V1 B2,TUBB2B,EEA1 57 ERK/MAPK 2,57E00 6,56E-02 12/183 (7%) 171/183 (93%) PLA2G4A,MAPK1,YWHA Signaling H,PPP1R12A,ETS2,RAC1, CRK,PPP2R5C,KRAS,STA T3,MAP2K1,ELF1

58 Dendritic Cell 2,55E00 6,88E-02 11/160 (7%) 149/160 (93%) IL1A,MAPK1,IL10,IL1RN, Maturation TYROBP,FCER1G,IL1B,FC GR2B,TNFRSF1B,TNF,TN FRSF11B 59 Axonal Guidance 2,54E00 4,99E-02 21/421 (5%) 400/421 (95%) SLIT3,PLXNA1,MAPK1,P Signaling DGFA,TUBB2A,GNG2,AR PC5,RAC1,EPHA4,CRK,K RAS,SLIT2,TUBB2B,GNB 1,GNB4,WIPF1,ACTR3,A DAM12,SEMA3C,MAP2K 1,GNG12

60 Graft-versus-Host 2,52E00 1,28E-01 5/39 (13%) 34/39 (87%) IL1A,IL1RN,FCER1G,IL1B, Disease Signaling TNF

61 IL-17A Signaling in 2,46E00 1,6E-01 4/25 (16%) 21/25 (84%) CXCL8,MAPK1,CXCL1,TN Gastric Cells F 62 LXR/RXR Activation 2,43E00 7,5E-02 9/120 (8%) 111/120 (93%) IL1A,CCL2,IL1RN,CD14,IL 1B,TNFRSF1B,TNF,CLU,T NFRSF11B 63 Ceramide 2,42E00 5E-01 2/4 (50%) 2/4 (50%) NAAA,ASAH1 Degradation 64 Type I Diabetes 2,36E00 7,92E-02 8/101 (8%) 93/101 (92%) MAPK1,FCER1G,BID,IL1B Mellitus Signaling ,TNFRSF1B,SOCS5,TNF,T NFRSF11B

65 Fc Epsilon RI 2,26E00 7,62E-02 8/105 (8%) 97/105 (92%) PLA2G4A,MAPK1,RAC1, Signaling FCER1G,LYN,KRAS,MAP2 K1,TNF 66 Role of MAPK 2,23E00 9,38E-02 6/64 (9%) 58/64 (91%) PLA2G4A,CCL2,MAPK1,K Signaling in the RAS,MAP2K1,TNF Pathogenesis of Influenza 67 Pancreatic 2,23E00 7,55E-02 8/106 (8%) 98/106 (92%) HMOX1,TFDP1,MAPK1,R Adenocarcinoma AC1,KRAS,STAT3,MAP2K 1,CDKN2B Signaling 68 α-Adrenergic 2,21E00 8,24E-02 7/85 (8%) 78/85 (92%) GNB1,GNB4,MAPK1,GN Signaling G2,KRAS,MAP2K1,GNG1 2 69 Regulation of Actin- 2,19E00 8,14E-02 7/86 (8%) 79/86 (92%) WIPF1,ACTR3,RHOQ,PP based Motility by P1R12A,ARPC5,RAC1,PIP 4K2A Rho 70 IL-15 Signaling 2,17E00 9,09E-02 6/66 (9%) 60/66 (91%) CXCL8,MAPK1,KRAS,STA T3,MAP2K1,TNF 71 Androgen Signaling 2,14E00 7,27E-02 8/110 (7%) 102/110 (93%) GNB1,GNB4,KAT2B,MAP K1,GNG2,GTF2H5,POLR 2K,GNG12 72 PAK Signaling 2,13E00 7,95E-02 7/88 (8%) 81/88 (92%) MAPK1,PDGFA,PAK1IP1, RAC1,KRAS,MAP2K1,TN F 73 CNTF Signaling 2,13E00 1,04E-01 5/48 (10%) 43/48 (90%) MAPK1,RPS6KA3,KRAS,S TAT3,MAP2K1 74 Hepatic Cholestasis 2,12E00 6,33E-02 10/158 (6%) 148/158 (94%) CXCL8,IL1A,IL1RN,ABCC 1,CD14,IL1B,TNFRSF1B,T NF,IRAK4,TNFRSF11B

75 G Protein Signaling 2,11E00 1,29E-01 4/31 (13%) 27/31 (87%) GNB1,GNB4,GNG2,GNG Mediated by Tubby 12

76 Role of NFAT in 2,1E00 6,29E-02 10/159 (6%) 149/159 (94%) GNB1,GNB4,MAPK1,GN Regulation of the G2,FCER1G,LYN,KRAS,FC GR2B,MAP2K1,GNG12 Immune Response

77 p38 MAPK 2,09E00 7,14E-02 8/112 (7%) 104/112 (93%) PLA2G4A,IL1A,IL1RN,RP Signaling S6KA3,IL1B,TNFRSF1B,T NF,IRAK4 78 IL-1 Signaling 2,06E00 7,69E-02 7/91 (8%) 84/91 (92%) GNB1,GNB4,IL1A,MAPK 1,GNG2,IRAK4,GNG12

79 Death Receptor 2,06E00 7,69E-02 7/91 (8%) 84/91 (92%) BID,TNFRSF1B,TNFRSF1 Signaling 0A,TNF,MAP4K4,PARP9, PARP14 80 IL-3 Signaling 2,02E00 8,45E-02 6/71 (8%) 65/71 (92%) CSF2RB,MAPK1,RAC1,KR AS,STAT3,MAP2K1 81 Hematopoiesis 2,02E00 1,21E-01 4/33 (12%) 29/33 (88%) CXCL8,IL1A,IL10,FCER1G from Pluripotent Stem Cells 82 IL-17 Signaling 1,99E00 8,33E-02 6/72 (8%) 66/72 (92%) CXCL8,CCL2,MAPK1,KRA S,CXCL1,MAP2K1 83 Gαi Signaling 1,98E00 6,84E-02 8/117 (7%) 109/117 (93%) GNB1,GNB4,MAPK1,NPY 1R,GNG2,KRAS,STAT3,G NG12 84 Epithelial Adherens 1,98E00 6,38E-02 9/141 (6%) 132/141 (94%) ACTR3,ARPC5,TUBB2A,R Junction Signaling AC1,CRK,KRAS,IQGAP1,C LIP1,TUBB2B

85 Ephrin B Signaling 1,96E00 8,22E-02 6/73 (8%) 67/73 (92%) GNB1,GNB4,MAPK1,GN G2,RAC1,GNG12 86 STAT3 Pathway 1,96E00 8,22E-02 6/73 (8%) 67/73 (92%) MAPK1,RAC1,KRAS,STAT 3,MAP2K1,SOCS5 87 B Cell Receptor 1,96E00 5,99E-02 10/167 (6%) 157/167 (94%) RAP2A,MAPK1,PAG1,RA Signaling C1,LYN,PIK3AP1,KRAS,F CGR2B,BCL2A1,MAP2K1

88 Role of IL-17A in 1,92E00 9,26E-02 5/54 (9%) 49/54 (91%) CXCL8,CCL2,MAPK1,CXC Arthritis L1,MAP2K1 89 Gαq Signaling 1,91E00 6,21E-02 9/145 (6%) 136/145 (94%) GNB1,HMOX1,GNB4,HT R2B,RHOQ,MAPK1,GNG 2,MAP2K1,GNG12

90 Airway Pathology 1,9E00 2,86E-01 2/7 (29%) 5/7 (71%) CXCL8,TNF in Chronic Obstructive Pulmonary Disease 91 Sphingomyelin 1,9E00 2,86E-01 2/7 (29%) 5/7 (71%) SGMS2,SGMS1 Metabolism 92 Paxillin Signaling 1,89E00 7,14E-02 7/98 (7%) 91/98 (93%) ITGAM,MAPK1,ITGAV,R AC1,CRK,KRAS,ITGB5

93 Altered T Cell and 1,88E00 7,89E-02 6/76 (8%) 70/76 (92%) IL1A,IL10,IL1RN,FCER1G, B Cell Signaling in IL1B,TNF Rheumatoid Arthritis

94 PI3K Signaling in B 1,86E00 6,5E-02 8/123 (7%) 115/123 (93%) MAPK1,RAC1,LYN,PIK3A Lymphocytes P1,KRAS,PLEKHA1,FCGR 2B,MAP2K1 95 PDGF Signaling 1,85E00 7,79E-02 6/77 (8%) 71/77 (92%) MAPK1,PDGFA,CRK,KRA S,STAT3,MAP2K1 96 Aldosterone 1,82E00 6E-02 9/150 (6%) 141/150 (94%) MAPK1,DNAJB4,SGK1,H Signaling in SPA13,HSPB8,KRAS,DNA JB6,PIP4K2A,MAP2K1 Epithelial Cells 97 Ceramide Signaling 1,8E00 7,59E-02 6/79 (8%) 73/79 (92%) PPP2R5C,KRAS,TNFRSF1 B,MAP2K1,TNF,TNFRSF1 1B 98 Systemic Lupus 1,8E00 5,65E-02 10/177 (6%) 167/177 (94%) IL1A,MAPK1,IL10,IL1RN, Erythematosus FCER1G,LYN,IL1B,KRAS,F CGR2B,TNF Signaling 99 Thyroid Cancer 1,76E00 1,03E-01 4/39 (10%) 35/39 (90%) MAPK1,KRAS,CXCL1,MA Signaling P2K1 100 HGF Signaling 1,76E00 6,73E-02 7/104 (7%) 97/104 (93%) MAPK1,ETS2,RAC1,KRAS ,STAT3,MAP2K1,ELF1

101 Germ Cell-Sertoli 1,75E00 5,84E-02 9/154 (6%) 145/154 (94%) RHOQ,MAPK1,TUBB2A, Cell Junction RAC1,KRAS,IQGAP1,MA P2K1,TNF,TUBB2B Signaling

102 Gαs Signaling 1,72E00 6,6E-02 7/106 (7%) 99/106 (93%) GNB1,GNB4,MAPK1,GN G2,HCK,MAP2K1,GNG12

103 Clathrin-mediated 1,69E00 5,43E-02 10/184 (5%) 174/184 (95%) MYO6,ACTR3,F2R,PDGF Endocytosis A,ARPC5,RAC1,RAB7A,C TTN,ITGB5,CLU Signaling

104 Cardiac β- 1,69E00 6,06E-02 8/132 (6%) 124/132 (94%) GNB1,AKAP13,GNB4,PP adrenergic P1R12A,PDE12,GNG2,PP P2R5C,GNG12 Signaling 105 Pathogenesis of 1,68E00 2,22E-01 2/9 (22%) 7/9 (78%) CCR1,CCL4 Multiple Sclerosis

106 Renin-Angiotensin 1,68E00 6,48E-02 7/108 (6%) 101/108 (94%) CCL2,MAPK1,RAC1,KRAS Signaling ,STAT3,MAP2K1,TNF

107 UVC-Induced 1,66E00 9,52E-02 4/42 (10%) 38/42 (90%) MAPK1,KRAS,ATR,MAP2 MAPK Signaling K1 108 Pyridoxal 5'- 1,65E00 7,94E-02 5/63 (8%) 58/63 (92%) FAM20B,MAPK1,SGK1,H phosphate Salvage IPK1,MAP2K1 Pathway 109 Thrombin Signaling 1,65E00 5,35E-02 10/187 (5%) 177/187 (95%) GNB1,GNB4,RHOQ,F2R, MAPK1,PPP1R12A,GNG 2,KRAS,MAP2K1,GNG12

110 Role of JAK family 1,6E00 1,2E-01 3/25 (12%) 22/25 (88%) MAPK1,OSMR,STAT3 kinases in IL-6-type Cytokine Signaling

111 G Beta Gamma 1,6E00 6,82E-02 6/88 (7%) 82/88 (93%) GNB1,GNB4,MAPK1,GN Signaling G2,KRAS,GNG12 112 Leukocyte 1,59E00 5,24E-02 10/191 (5%) 181/191 (95%) WIPF1,ITGAM,MAPK1,E Extravasation ZR,RAC1,CYBB,CRK,NCF4 ,CTTN,MSN Signaling 113 Asparagine 1,59E00 1E00 1/1 (100%) 0/1 (0%) ASNS Biosynthesis I 114 Calcium Transport I 1,59E00 2E-01 2/10 (20%) 8/10 (80%) ATP2B1,ANXA5

115 Methylglyoxal 1,59E00 2E-01 2/10 (20%) 8/10 (80%) AKR1C1/AKR1C2,AKR1C Degradation III 3 116 Xenobiotic 1,58E00 4,84E-02 12/248 (5%) 236/248 (95%) HMOX1,IL1A,MAPK1,AL Metabolism DH1A3,SULT1A1,NQO1,I L1B,PPP2R5C,KRAS,MAP Signaling 2K1,TNF,AHR 117 14-3-3-mediated 1,56E00 6,14E-02 7/114 (6%) 107/114 (94%) MAPK1,YWHAH,TUBB2A Signaling ,KRAS,MAP2K1,TNF,TUB B2B 118 MSP-RON Signaling 1,53E00 8,7E-02 4/46 (9%) 42/46 (91%) CSF2RB,ITGAM,CCL2,TN Pathway F

119 GDNF Family 1,52E00 7,35E-02 5/68 (7%) 63/68 (93%) DOK5,MAPK1,RAC1,KRA Ligand-Receptor S,MAP2K1 Interactions 120 Macropinocytosis 1,52E00 7,35E-02 5/68 (7%) 63/68 (93%) PDGFA,RAC1,CD14,KRAS Signaling ,ITGB5 121 Antioxidant Action 1,51E00 6,52E-02 6/92 (7%) 86/92 (93%) CSF2RB,HMOX1,PLA2G4 of Vitamin C A,MAPK1,TNF,TXNRD1

122 Renal Cell 1,5E00 7,25E-02 5/69 (7%) 64/69 (93%) MAPK1,RAC1,CRK,KRAS, Carcinoma MAP2K1 Signaling 123 p70S6K Signaling 1,49E00 5,93E-02 7/118 (6%) 111/118 (94%) F2R,MAPK1,YWHAH,LYN ,PPP2R5C,KRAS,MAP2K1

124 RhoA Signaling 1,49E00 5,93E-02 7/118 (6%) 111/118 (94%) PLXNA1,ACTR3,PPP1R12 A,EZR,ARPC5,PIP4K2A,M SN 125 P2Y Purigenic 1,49E00 5,93E-02 7/118 (6%) 111/118 (94%) GNB1,GNB4,MAPK1,GN Receptor Signaling G2,KRAS,MAP2K1,GNG1 2 Pathway

126 Glioma Signaling 1,47E00 6,38E-02 6/94 (6%) 88/94 (94%) TFDP1,MAPK1,PDGFA,K RAS,MAP2K1,CDKN2B

127 TNFR2 Signaling 1,47E00 1,07E-01 3/28 (11%) 25/28 (89%) TNFAIP3,TNFRSF1B,TNF

128 Colorectal Cancer 1,45E00 4,78E-02 11/230 (5%) 219/230 (95%) GNB1,GNB4,RHOQ,MAP Metastasis K1,GNG2,RAC1,KRAS,ST AT3,MAP2K1,TNF,GNG1 Signaling 2

129 FLT3 Signaling in 1,45E00 7,04E-02 5/71 (7%) 66/71 (93%) MAPK1,RPS6KA3,KRAS,S Hematopoietic TAT3,MAP2K1 Progenitor Cells 130 Telomerase 1,43E00 6,25E-02 6/96 (6%) 90/96 (94%) MAPK1,ETS2,PPP2R5C,K Signaling RAS,MAP2K1,ELF1 131 IGF-1 Signaling 1,43E00 6,25E-02 6/96 (6%) 90/96 (94%) MAPK1,YWHAH,KRAS,ST AT3,MAP2K1,SOCS5 132 JAK/Stat Signaling 1,43E00 6,94E-02 5/72 (7%) 67/72 (93%) MAPK1,KRAS,STAT3,MA P2K1,SOCS5 133 LPS/IL-1 Mediated 1,42E00 4,9E-02 10/204 (5%) 194/204 (95%) IL1A,IL1RN,ALDH1A3,SU Inhibition of RXR LT1A1,ACSL5,CD14,IL1B, TNFRSF1B,TNF,TNFRSF1 Function 1B

134 LPS-stimulated 1,41E00 6,85E-02 5/73 (7%) 68/73 (93%) MAPK1,RAC1,CD14,KRA MAPK Signaling S,MAP2K1 135 Prolactin Signaling 1,41E00 6,85E-02 5/73 (7%) 68/73 (93%) MAPK1,KRAS,STAT3,MA P2K1,SOCS5 136 p53 Signaling 1,4E00 6,12E-02 6/98 (6%) 92/98 (94%) KAT2B,RRM2B,PERP,TIG AR,ATR,TNFRSF10A

137 Role of IL-17A in 1,37E00 1,54E-01 2/13 (15%) 11/13 (85%) CXCL8,CXCL1 Psoriasis 138 Bile Acid 1,37E00 1,54E-01 2/13 (15%) 11/13 (85%) AKR1C1/AKR1C2,AKR1C Biosynthesis, 3 Neutral Pathway 139 Estrogen Receptor 1,36E00 5,56E-02 7/126 (6%) 119/126 (94%) KAT2B,MED20,MAPK1,G Signaling TF2H5,KRAS,POLR2K,M AP2K1

140 Semaphorin 1,36E00 7,69E-02 4/52 (8%) 48/52 (92%) PLXNA1,RHOQ,MAPK1,R Signaling in AC1 Neurons 141 MIF-mediated 1,36E00 9,68E-02 3/31 (10%) 28/31 (90%) PLA2G4A,MAPK1,CD14 Glucocorticoid Regulation 142 Insulin Receptor 1,35E00 5,51E-02 7/127 (6%) 120/127 (94%) RHOQ,MAPK1,PPP1R12 Signaling A,SGK1,CRK,KRAS,MAP2 K1 143 Acute Myeloid 1,34E00 6,58E-02 5/76 (7%) 71/76 (93%) CSF2RB,MAPK1,KRAS,ST Leukemia Signaling AT3,MAP2K1

144 UDP-D-xylose and 1,3E00 5E-01 1/2 (50%) 1/2 (50%) UGDH UDP-D-glucuronate Biosynthesis

145 Glutamine 1,3E00 5E-01 1/2 (50%) 1/2 (50%) GLS Degradation I 146 Thrombopoietin 1,28E00 7,27E-02 4/55 (7%) 51/55 (93%) MAPK1,KRAS,STAT3,MA Signaling P2K1 147 Natural Killer Cell 1,28E00 5,71E-02 6/105 (6%) 99/105 (94%) MAPK1,TYROBP,RAC1,F Signaling CER1G,KRAS,MAP2K1 148 Relaxin Signaling 1,27E00 5,3E-02 7/132 (5%) 125/132 (95%) GNB1,GNB4,MAPK1,PDE 12,GNG2,MAP2K1,GNG 12 149 Sphingosine-1- 1,26E00 5,66E-02 6/106 (6%) 100/106 (94%) NAAA,RHOQ,MAPK1,PD phosphate GFA,RAC1,ASAH1 Signaling 150 NGF Signaling 1,26E00 5,66E-02 6/106 (6%) 100/106 (94%) MAPK1,RAC1,RPS6KA3,C RK,KRAS,MAP2K1 151 ErbB2-ErbB3 1,26E00 7,14E-02 4/56 (7%) 52/56 (93%) MAPK1,KRAS,STAT3,MA Signaling P2K1 152 Parkinson's 1,26E00 1,33E-01 2/15 (13%) 13/15 (87%) UCHL1,MAPK1 Signaling 153 Tight Junction 1,22E00 4,88E-02 8/164 (5%) 156/164 (95%) NSF,RAC1,NAPG,PPP2R5 Signaling C,CNKSR3,TNFRSF1B,TN F,TNFRSF11B 154 Retinoic acid 1,21E00 6,9E-02 4/58 (7%) 54/58 (93%) BID,TNFRSF10A,PARP9,P Mediated ARP14 Apoptosis Signaling

155 Extrinsic 1,21E00 1,25E-01 2/16 (13%) 14/16 (88%) F13A1,THBD Prothrombin Activation Pathway

156 Induction of 1,19E00 6,78E-02 4/59 (7%) 55/59 (93%) BID,TNFRSF1B,TNF,TNFR Apoptosis by HIV1 SF11B

157 Eicosanoid 1,19E00 6,78E-02 4/59 (7%) 55/59 (93%) PLA2G4A,PTGFR,AKR1C Signaling 3,HPGDS 158 Melanocyte 1,19E00 5,95E-02 5/84 (6%) 79/84 (94%) MAPK1,RPS6KA3,CRK,KR Development and AS,MAP2K1 Pigmentation Signaling

159 Huntington's 1,19E00 4,44E-02 10/225 (4%) 215/225 (96%) GNB1,NSF,GNB4,MAPK1 Disease Signaling ,SGK1,GLS,GNG2,NAPG, POLR2K,GNG12

160 Neuregulin 1,17E00 5,88E-02 5/85 (6%) 80/85 (94%) MAPK1,CRK,KRAS,MAP2 Signaling K1,EREG 161 FGF Signaling 1,17E00 5,88E-02 5/85 (6%) 80/85 (94%) MAPK1,RAC1,CRK,STAT3 ,MAP2K1 162 Activation of IRF by 1,17E00 6,67E-02 4/60 (7%) 56/60 (93%) IFIH1,IL10,DDX58,TNF Cytosolic Pattern Recognition Receptors

163 Role of PI3K/AKT 1,17E00 6,67E-02 4/60 (7%) 56/60 (93%) KPNA3,MAPK1,CRK,MAP Signaling in the 2K1 Pathogenesis of Influenza 164 Type II Diabetes 1,17E00 5,36E-02 6/112 (5%) 106/112 (95%) MAPK1,ACSL5,TNFRSF1 Mellitus Signaling B,SOCS5,TNF,TNFRSF11 B

165 Allograft Rejection 1,17E00 8,11E-02 3/37 (8%) 34/37 (92%) IL10,FCER1G,TNF Signaling

166 Regulation of eIF4 1,16E00 5E-02 7/140 (5%) 133/140 (95%) MAPK1,RPS27L,PPP2R5 and p70S6K C,KRAS,EIF2S1,MAP2K1, EIF1AX Signaling 167 CREB Signaling in 1,16E00 4,73E-02 8/169 (5%) 161/169 (95%) GNB1,GNB4,MAPK1,GN Neurons G2,KRAS,POLR2K,MAP2 K1,GNG12 168 Bladder Cancer 1,16E00 5,81E-02 5/86 (6%) 81/86 (94%) CXCL8,TFDP1,MAPK1,KR Signaling AS,MAP2K1 169 FAK Signaling 1,16E00 5,81E-02 5/86 (6%) 81/86 (94%) MAPK1,RAC1,CRK,KRAS, MAP2K1 170 ERK5 Signaling 1,15E00 6,56E-02 4/61 (7%) 57/61 (93%) YWHAH,SGK1,RPS6KA3, KRAS 171 UVA-Induced 1,14E00 5,75E-02 5/87 (6%) 82/87 (94%) MAPK1,RPS6KA3,KRAS,P MAPK Signaling ARP9,PARP14 172 MIF Regulation of 1,11E00 7,69E-02 3/39 (8%) 36/39 (92%) PLA2G4A,MAPK1,CD14 Innate Immunity

173 Docosahexaenoic 1,11E00 7,69E-02 3/39 (8%) 36/39 (92%) BID,IL1B,BCL2A1 Acid (DHA) Signaling 174 Cell Cycle: G1/S 1,11E00 6,35E-02 4/63 (6%) 59/63 (94%) TFDP1,PAK1IP1,ATR,CDK Checkpoint N2B Regulation 175 VEGF Signaling 1,11E00 5,62E-02 5/89 (6%) 84/89 (94%) MAPK1,KRAS,EIF2S1,MA P2K1,EIF1AX 176 PTEN Signaling 1,1E00 5,13E-02 6/117 (5%) 111/117 (95%) MAPK1,YWHAH,RAC1,K RAS,CNKSR3,MAP2K1

177 Salvage Pathways 1,09E00 5,56E-02 5/90 (6%) 85/90 (94%) FAM20B,MAPK1,SGK1,H of Pyrimidine IPK1,MAP2K1 Ribonucleotides

178 CD40 Signaling 1,09E00 6,25E-02 4/64 (6%) 60/64 (94%) MAPK1,TNFAIP3,STAT3, MAP2K1 179 IL-17A Signaling in 1,09E00 6,25E-02 4/64 (6%) 60/64 (94%) MAPK1,CXCL1,STAT3,M Airway Cells AP2K1 180 Role of PKR in 1,09E00 7,5E-02 3/40 (8%) 37/40 (93%) BID,EIF2S1,TNF Interferon Induction and Antiviral Response

181 Angiopoietin 1,07E00 6,15E-02 4/65 (6%) 61/65 (94%) ANGPT2,GRB14,CRK,KR Signaling AS 182 Non-Small Cell 1,07E00 6,15E-02 4/65 (6%) 61/65 (94%) TFDP1,MAPK1,KRAS,MA Lung Cancer P2K1 Signaling 183 FcγRIIB Signaling in 1,06E00 7,32E-02 3/41 (7%) 38/41 (93%) LYN,KRAS,FCGR2B B Lymphocytes

184 Chronic Myeloid 1,06E00 5,43E-02 5/92 (5%) 87/92 (95%) TFDP1,MAPK1,CRK,KRAS Leukemia Signaling ,MAP2K1

185 Mouse Embryonic 1,06E00 5,43E-02 5/92 (5%) 87/92 (95%) MAPK1,KRAS,STAT3,MA Stem Cell P2K1,ID4 Pluripotency

186 Melanoma 1,04E00 7,14E-02 3/42 (7%) 39/42 (93%) MAPK1,KRAS,MAP2K1 Signaling 187 Agrin Interactions 1,03E00 5,97E-02 4/67 (6%) 63/67 (94%) MAPK1,RAC1,KRAS,CTT at Neuromuscular N Junction

188 T Cell Receptor 1,03E00 5,32E-02 5/94 (5%) 89/94 (95%) MAPK1,PAG1,RAC1,KRA Signaling S,MAP2K1 189 mTOR Signaling 1,03E00 4,42E-02 8/181 (4%) 173/181 (96%) HMOX1,RHOQ,MAPK1,R PS27L,RAC1,RPS6KA3,PP P2R5C,KRAS 190 iNOS Signaling 1,01E00 6,98E-02 3/43 (7%) 40/43 (93%) MAPK1,CD14,IRAK4

191 Airway 1,01E00 2,5E-01 1/4 (25%) 3/4 (75%) TNF Inflammation in Asthma 192 Heme Degradation 1,01E00 2,5E-01 1/4 (25%) 3/4 (75%) HMOX1

193 Molybdenum 1,01E00 2,5E-01 1/4 (25%) 3/4 (75%) MOCS2 Cofactor Biosynthesis 194 Dopamine 1E00 9,52E-02 2/21 (10%) 19/21 (90%) ALDH1A3,SULT1A1 Degradation 195 Growth Hormone 9,98E- 5,8E-02 4/69 (6%) 65/69 (94%) MAPK1,RPS6KA3,STAT3, Signaling 01 SOCS5

196 CDK5 Signaling 9,71E- 5,1E-02 5/98 (5%) 93/98 (95%) MAPK1,PPP1R12A,PPP2 01 R5C,KRAS,MAP2K1 197 RAR Activation 9,65E- 4,28E-02 8/187 (4%) 179/187 (96%) CSF2RB,KAT2B,AKR1C3, 01 MAPK1,ALDH1A3,RAC1, GTF2H5,MAP2K1 198 Cardiac 9,64E- 4,13E-02 9/218 (4%) 209/218 (96%) ADSS,GNB1,GNB4,RHOQ Hypertrophy 01 ,MAPK1,GNG2,KRAS,MA P2K1,GNG12 Signaling 199 Caveolar-mediated 9,64E- 5,63E-02 4/71 (6%) 67/71 (94%) ITGAM,ITGAV,COPB1,IT Endocytosis 01 GB5 Signaling

200 NF-κB Activation 9,31E- 5,48E-02 4/73 (5%) 69/73 (95%) MAPK1,ITGAV,KRAS,ITG by Viruses 01 B5 201 TNFR1 Signaling 9,25E- 6,38E-02 3/47 (6%) 44/47 (94%) TNFAIP3,BID,TNF 01 202 IL-12 Signaling and 9,2E-01 4,58E-02 6/131 (5%) 125/131 (95%) MAPK1,IL10,RAB7A,MA Production in P2K1,TNF,CLU Macrophages 203 VEGF Family Ligand-9,15E- 5,41E-02 4/74 (5%) 70/74 (95%) PLA2G4A,MAPK1,KRAS, Receptor 01 MAP2K1 Interactions 204 Creatine- 9,15E- 2E-01 1/5 (20%) 4/5 (80%) MAP4K4 phosphate 01 Biosynthesis 205 Rapoport- 9,15E- 2E-01 1/5 (20%) 4/5 (80%) TIGAR Luebering 01 Glycolytic Shunt 206 IL-22 Signaling 9,03E- 8,33E-02 2/24 (8%) 22/24 (92%) MAPK1,STAT3 01 207 Tumoricidal 9,03E- 8,33E-02 2/24 (8%) 22/24 (92%) SRGN,BID Function of 01 Hepatic Natural Killer Cells 208 Synaptic Long 8,97E- 4,51E-02 6/133 (5%) 127/133 (95%) PLA2G4A,MAPK1,LYN,P Term Depression 01 PP2R5C,KRAS,MAP2K1 209 Cell Cycle: G2/M 8,86E- 6,12E-02 3/49 (6%) 46/49 (94%) KAT2B,YWHAH,ATR DNA Damage 01 Checkpoint Regulation 210 Regulation of IL-2 8,85E- 5,26E-02 4/76 (5%) 72/76 (95%) MAPK1,RAC1,KRAS,MAP Expression in 01 2K1 Activated and Anergic T Lymphocytes 211 Cyclins and Cell 8,7E-01 5,19E-02 4/77 (5%) 73/77 (95%) TFDP1,PPP2R5C,ATR,CD Cycle Regulation KN2B 212 EIF2 Signaling 8,42E- 4,14E-02 7/169 (4%) 162/169 (96%) EIF2AK4,MAPK1,RPS27L, 01 KRAS,EIF2S1,MAP2K1,EI F1AX 213 Sertoli Cell-Sertoli 8,42E- 4,14E-02 7/169 (4%) 162/169 (96%) MAPK1,TUBB2A,RAC1,K Cell Junction 01 RAS,MAP2K1,TNF,TUBB 2B Signaling

214 CD28 Signaling in T 8,42E- 4,63E-02 5/108 (5%) 103/108 (95%) ACTR3,ARPC5,RAC1,FCE Helper Cells 01 R1G,MAP2K1 215 Thioredoxin 8,41E- 1,67E-01 1/6 (17%) 5/6 (83%) TXNRD1 Pathway 01 216 Purine 8,41E- 1,67E-01 1/6 (17%) 5/6 (83%) PGM2 Ribonucleosides 01 Degradation to Ribose-1- phosphate 217 GDP-glucose 8,41E- 1,67E-01 1/6 (17%) 5/6 (83%) PGM2 Biosynthesis 01 218 Endometrial 8,3E-01 5,77E-02 3/52 (6%) 49/52 (94%) MAPK1,KRAS,MAP2K1 Cancer Signaling 219 UVB-Induced 8,3E-01 5,77E-02 3/52 (6%) 49/52 (94%) MAPK1,RPS6KA3,MAP2 MAPK Signaling K1 220 Prostate Cancer 8,27E- 5E-02 4/80 (5%) 76/80 (95%) TFDP1,MAPK1,KRAS,MA Signaling 01 P2K1 221 Cytotoxic T 8,2E-01 7,41E-02 2/27 (7%) 25/27 (93%) FCER1G,BID Lymphocyte- mediated Apoptosis of Target Cells 222 IL-2 Signaling 8,13E- 5,66E-02 3/53 (6%) 50/53 (94%) MAPK1,KRAS,MAP2K1 01 223 Role of NFAT in 7,97E- 4,02E-02 7/174 (4%) 167/174 (96%) GNB1,GNB4,MAPK1,GN Cardiac 01 G2,KRAS,MAP2K1,GNG1 2 Hypertrophy 224 Regulation of 7,96E- 5,56E-02 3/54 (6%) 51/54 (94%) MAPK1,EZR,KRAS Cellular Mechanics 01 by Calpain Protease 225 Intrinsic 7,95E- 7,14E-02 2/28 (7%) 26/28 (93%) F13A1,THBD Prothrombin 01 Activation Pathway

226 Glioblastoma 7,83E- 4,17E-02 6/144 (4%) 138/144 (96%) RHOQ,MAPK1,PDGFA,R Multiforme 01 AC1,KRAS,MAP2K1 Signaling 227 Glucose and 7,8E-01 1,43E-01 1/7 (14%) 6/7 (86%) PGM2 Glucose-1- phosphate Degradation 228 EGF Signaling 7,63E- 5,36E-02 3/56 (5%) 53/56 (95%) MAPK1,STAT3,MAP2K1 01 229 Glutamate 7,63E- 5,36E-02 3/56 (5%) 53/56 (95%) GNB1,GLS,GNG2 Receptor Signaling 01

230 Crosstalk between 7,61E- 4,71E-02 4/85 (5%) 81/85 (95%) CSF2RB,TYROBP,TNFRSF Dendritic Cells and 01 1B,TNF Natural Killer Cells

231 ErbB Signaling 7,61E- 4,71E-02 4/85 (5%) 81/85 (95%) MAPK1,KRAS,MAP2K1,E 01 REG 232 HIPPO signaling 7,61E- 4,71E-02 4/85 (5%) 81/85 (95%) YWHAH,PPP1R12A,FAT4 01 ,PPP2R5C 233 Retinoate 7,48E- 6,67E-02 2/30 (7%) 28/30 (93%) AKR1C3,ALDH1A3 Biosynthesis I 01 234 Role of 7,42E- 3,76E-02 8/213 (4%) 205/213 (96%) IL1A,MAPK1,IL10,IL1RN, Osteoblasts, 01 IL1B,TNFRSF1B,TNF,TNF RSF11B Osteoclasts and Chondrocytes in Rheumatoid Arthritis 235 Gap Junction 7,36E- 4,03E-02 6/149 (4%) 143/149 (96%) HTR2B,MAPK1,TUBB2A, Signaling 01 KRAS,MAP2K1,TUBB2B 236 TGF-β Signaling 7,36E- 4,6E-02 4/87 (5%) 83/87 (95%) MAPK1,KRAS,SERPINE1, 01 MAP2K1 237 Myc Mediated 7,32E- 5,17E-02 3/58 (5%) 55/58 (95%) YWHAH,BID,KRAS Apoptosis Signaling 01

238 ErbB4 Signaling 7,32E- 5,17E-02 3/58 (5%) 55/58 (95%) MAPK1,KRAS,MAP2K1 01 239 Phosphatidylethan 7,27E- 1,25E-01 1/8 (13%) 7/8 (88%) EPT1 olamine 01 Biosynthesis II 240 Citrulline 7,27E- 1,25E-01 1/8 (13%) 7/8 (88%) GLS Biosynthesis 01 241 Superoxide 7,27E- 1,25E-01 1/8 (13%) 7/8 (88%) NQO1 Radicals 01 Degradation 242 4-1BB Signaling in 7,26E- 6,45E-02 2/31 (6%) 29/31 (94%) MAPK1,MAP2K1 T Lymphocytes 01

243 PI3K/AKT Signaling 7,11E- 4,17E-02 5/120 (4%) 115/120 (96%) MAPK1,YWHAH,PPP2R5 01 C,KRAS,MAP2K1 244 Role of JAK2 in 7,05E- 6,25E-02 2/32 (6%) 30/32 (94%) STAT3,SOCS5 Hormone-like 01 Cytokine Signaling

245 Role of JAK1 and 7,02E- 5E-02 3/60 (5%) 57/60 (95%) MAPK1,KRAS,STAT3 JAK3 in γc Cytokine 01 Signaling 246 Stearate 6,85E- 6,06E-02 2/33 (6%) 31/33 (94%) PPT1,ACSL5 Biosynthesis I 01 (Animals) 247 Prostanoid 6,81E- 1,11E-01 1/9 (11%) 8/9 (89%) HPGDS Biosynthesis 01 248 Glycogen 6,81E- 1,11E-01 1/9 (11%) 8/9 (89%) PGM2 Degradation II 01 249 Leucine 6,81E- 1,11E-01 1/9 (11%) 8/9 (89%) BCAT1 Degradation I 01 250 FXR/RXR Activation 6,73E- 4,03E-02 5/124 (4%) 119/124 (96%) IL1A,IL1RN,IL1B,TNF,CL 01 U 251 IL-9 Signaling 6,65E- 5,88E-02 2/34 (6%) 32/34 (94%) STAT3,TNF 01 252 Autoimmune 6,65E- 5,88E-02 2/34 (6%) 32/34 (94%) IL10,FCER1G Thyroid Disease 01 Signaling 253 IL-17A Signaling in 6,47E- 5,71E-02 2/35 (6%) 33/35 (94%) CCL2,MAPK1 Fibroblasts 01 254 Estrogen 6,47E- 5,71E-02 2/35 (6%) 33/35 (94%) AKR1C3,CYP2U1 Biosynthesis 01 255 Nucleotide Excision 6,47E- 5,71E-02 2/35 (6%) 33/35 (94%) GTF2H5,POLR2K Repair Pathway 01

256 Acyl-CoA 6,41E- 1E-01 1/10 (10%) 9/10 (90%) PPT1 Hydrolysis 01 257 Erythropoietin 6,1E-01 4,48E-02 3/67 (4%) 64/67 (96%) MAPK1,KRAS,MAP2K1 Signaling 258 Neurotrophin/TRK 6,1E-01 4,48E-02 3/67 (4%) 64/67 (96%) MAPK1,KRAS,MAP2K1 Signaling 259 phagosome 6,05E- 4,04E-02 4/99 (4%) 95/99 (96%) RHOQ,FCER1G,FCGR2B, formation 01 MARCO 260 Glycogen 6,05E- 9,09E-02 1/11 (9%) 10/11 (91%) PGM2 Degradation III 01 261 Purine Nucleotides 6,05E- 9,09E-02 1/11 (9%) 10/11 (91%) ADSS De Novo 01 Biosynthesis II

262 PPARα/RXRα 6,04E- 3,64E-02 6/165 (4%) 159/165 (96%) MAPK1,IL1B,KRAS,MAP2 Activation 01 K1,MAP4K4,ITGB5 263 Netrin Signaling 5,79E- 5,13E-02 2/39 (5%) 37/39 (95%) RAC1,ENAH 01 264 Androgen 5,73E- 8,33E-02 1/12 (8%) 11/12 (92%) AKR1C3 Biosynthesis 01 265 Small Cell Lung 5,63E- 4,23E-02 3/71 (4%) 68/71 (96%) TFDP1,BID,CDKN2B Cancer Signaling 01 266 PEDF Signaling 5,63E- 4,23E-02 3/71 (4%) 68/71 (96%) MAPK1,RAC1,KRAS 01 267 Role of RIG1-like 5,49E- 4,88E-02 2/41 (5%) 39/41 (95%) IFIH1,DDX58 Receptors in 01 Antiviral Innate Immunity 268 Dermatan Sulfate 5,49E- 4,88E-02 2/41 (5%) 39/41 (95%) SULT1A1,DSEL Biosynthesis (Late 01 Stages)

269 Fatty Acid 5,43E- 7,69E-02 1/13 (8%) 12/13 (92%) ACSL5 Activation 01 270 Choline 5,43E- 7,69E-02 1/13 (8%) 12/13 (92%) HMOX1 Biosynthesis III 01 271 Histamine 5,43E- 7,69E-02 1/13 (8%) 12/13 (92%) ALDH1A3 Degradation 01 272 Leptin Signaling in 5,41E- 4,11E-02 3/73 (4%) 70/73 (96%) MAPK1,STAT3,MAP2K1 Obesity 01 273 BMP signaling 5,31E- 4,05E-02 3/74 (4%) 71/74 (96%) MAPK1,KRAS,MAP2K1 pathway 01 274 Role of NANOG in 5,24E- 3,7E-02 4/108 (4%) 104/108 (96%) MAPK1,KRAS,STAT3,MA Mammalian 01 P2K1 Embryonic Stem Cell Pluripotency

275 PKCθ Signaling in T 5,24E- 3,7E-02 4/108 (4%) 104/108 (96%) MAPK1,RAC1,FCER1G,K Lymphocytes 01 RAS

276 Isoleucine 5,16E- 7,14E-02 1/14 (7%) 13/14 (93%) BCAT1 Degradation I 01 277 Superpathway of 5,16E- 7,14E-02 1/14 (7%) 13/14 (93%) GLS Citrulline 01 Metabolism 278 Colanic Acid 5,16E- 7,14E-02 1/14 (7%) 13/14 (93%) UGDH Building Blocks 01 Biosynthesis 279 Vitamin-C 5,16E- 7,14E-02 1/14 (7%) 13/14 (93%) TXNRD1 Transport 01 280 Molecular 5,07E- 3,07E-02 11/358 (3%) 347/358 (97%) RAP2A,RHOQ,TFDP1,MA Mechanisms of 01 PK1,RAC1,BID,CRK,KRAS ,ATR,MAP2K1,CDKN2B Cancer 281 VDR/RXR 5,01E- 3,9E-02 3/77 (4%) 74/77 (96%) PDGFA,CD14,THBD Activation 01 282 ILK Signaling 4,96E- 3,31E-02 6/181 (3%) 175/181 (97%) RHOQ,MAPK1,PPP1R12 01 A,PPP2R5C,TNF,ITGB5 283 Melatonin 4,94E- 4,44E-02 2/45 (4%) 43/45 (96%) CYP2U1,SULT1A1 Degradation I 01 284 Oxidative Ethanol 4,92E- 6,67E-02 1/15 (7%) 14/15 (93%) ALDH1A3 Degradation III 01 285 Reelin Signaling in 4,82E- 3,8E-02 3/79 (4%) 76/79 (96%) HCK,LYN,PAFAH1B1 Neurons 01 286 Heparan Sulfate 4,69E- 4,26E-02 2/47 (4%) 45/47 (96%) SULT1A1,GLCE Biosynthesis (Late 01 Stages) 287 RAN Signaling 4,69E- 6,25E-02 1/16 (6%) 15/16 (94%) KPNA3 01 288 Granzyme B 4,69E- 6,25E-02 1/16 (6%) 15/16 (94%) BID Signaling 01 289 CDP-diacylglycerol 4,69E- 6,25E-02 1/16 (6%) 15/16 (94%) LCLAT1 Biosynthesis I 01

290 Fatty Acid α- 4,69E- 6,25E-02 1/16 (6%) 15/16 (94%) ALDH1A3 oxidation 01 291 Gα12/13 Signaling 4,68E- 3,48E-02 4/115 (3%) 111/115 (97%) F2R,MAPK1,KRAS,MAP2 01 K1 292 Protein Kinase A 4,64E- 2,99E-02 11/368 (3%) 357/368 (97%) GNB1,AKAP13,GNB4,MA Signaling 01 PK1,YWHAH,PPP1R12A, PDE12,PTPRB,GNG2,MA P2K1,GNG12 293 Synaptic Long 4,61E- 3,45E-02 4/116 (3%) 112/116 (97%) PPP1R12A,MAPK1,KRAS, Term Potentiation 01 MAP2K1

294 Ephrin A Signaling 4,57E- 4,17E-02 2/48 (4%) 46/48 (96%) RAC1,EPHA4 01 295 γ-linolenate 4,48E- 5,88E-02 1/17 (6%) 16/17 (94%) ACSL5 Biosynthesis II 01 (Animals) 296 Mitochondrial L- 4,48E- 5,88E-02 1/17 (6%) 16/17 (94%) ACSL5 carnitine Shuttle 01 Pathway 297 Putrescine 4,48E- 5,88E-02 1/17 (6%) 16/17 (94%) ALDH1A3 Degradation III 01 298 Assembly of RNA 4,35E- 4E-02 2/50 (4%) 48/50 (96%) GTF2H5,POLR2K Polymerase II 01 Complex 299 Superpathway of 4,35E- 4E-02 2/50 (4%) 48/50 (96%) CYP2U1,SULT1A1 Melatonin 01 Degradation 300 TR/RXR Activation 4,3E-01 3,53E-02 3/85 (4%) 82/85 (96%) HP,AKR1C1/AKR1C2,AKR 1C3 301 Tryptophan 4,28E- 5,56E-02 1/18 (6%) 17/18 (94%) ALDH1A3 Degradation X 01 (Mammalian, via Tryptamine) 302 Phosphatidylglycer 4,28E- 5,56E-02 1/18 (6%) 17/18 (94%) LCLAT1 ol Biosynthesis II 01 (Non-plastidic)

303 Valine Degradation 4,28E- 5,56E-02 1/18 (6%) 17/18 (94%) BCAT1 I 01 304 CD27 Signaling in 4,24E- 3,92E-02 2/51 (4%) 49/51 (96%) BID,MAP2K1 Lymphocytes 01 305 Serotonin 4,24E- 3,92E-02 2/51 (4%) 49/51 (96%) ALDH1A3,SULT1A1 Degradation 01 306 Phospholipases 4,13E- 3,85E-02 2/52 (4%) 50/52 (96%) HMOX1,PLA2G4A 01 307 GADD45 Signaling 4,1E-01 5,26E-02 1/19 (5%) 18/19 (95%) ATR

308 Ethanol 4,1E-01 5,26E-02 1/19 (5%) 18/19 (95%) ALDH1A3 Degradation IV 309 DNA damage- 4,1E-01 5,26E-02 1/19 (5%) 18/19 (95%) ATR induced 14-3-3σ Signaling 310 Virus Entry via 3,98E- 3,37E-02 3/89 (3%) 86/89 (97%) RAC1,KRAS,ITGB5 Endocytic 01 Pathways 311 Lymphotoxin β 3,94E- 3,7E-02 2/54 (4%) 52/54 (96%) MAPK1,CXCL1 Receptor Signaling 01

312 Heparan Sulfate 3,94E- 3,7E-02 2/54 (4%) 52/54 (96%) SULT1A1,GLCE Biosynthesis 01 313 Dermatan Sulfate 3,94E- 3,7E-02 2/54 (4%) 52/54 (96%) SULT1A1,DSEL Biosynthesis 01

314 Lipid Antigen 3,93E- 5E-02 1/20 (5%) 19/20 (95%) FCER1G Presentation by 01 CD1 315 GNRH Signaling 3,87E- 3,15E-02 4/127 (3%) 123/127 (97%) MAPK1,RAC1,KRAS,MAP 01 2K1 316 Role of CHK 3,84E- 3,64E-02 2/55 (4%) 53/55 (96%) PPP2R5C,ATR Proteins in Cell 01 Cycle Checkpoint Control

317 Ovarian Cancer 3,81E- 3,12E-02 4/128 (3%) 124/128 (97%) TFDP1,MAPK1,KRAS,MA Signaling 01 P2K1 318 Endothelin-1 3,81E- 3,03E-02 5/165 (3%) 160/165 (97%) HMOX1,PLA2G4A,EDNR Signaling 01 B,MAPK1,KRAS 319 Polyamine 3,77E- 4,76E-02 1/21 (5%) 20/21 (95%) KRAS Regulation in Colon 01 Cancer 320 Pyrimidine 3,77E- 4,76E-02 1/21 (5%) 20/21 (95%) RRM2B Deoxyribonucleoti 01 des De Novo Biosynthesis I 321 Endoplasmic 3,77E- 4,76E-02 1/21 (5%) 20/21 (95%) EIF2S1 Reticulum Stress 01 Pathway 322 Glutathione- 3,61E- 4,55E-02 1/22 (5%) 21/22 (95%) HPGDS mediated 01 Detoxification 323 cAMP-mediated 3,37E- 2,83E-02 6/212 (3%) 206/212 (97%) AKAP13,MAPK1,NPY1R, signaling 01 PDE12,STAT3,MAP2K1 324 iCOS-iCOSL 3,37E- 3,06E-02 3/98 (3%) 95/98 (97%) RAC1,FCER1G,PLEKHA1 Signaling in T 01 Helper Cells 325 Protein 3,34E- 2,79E-02 7/251 (3%) 244/251 (97%) UCHL1,MED20,DNAJB4, Ubiquitination 01 UBR1,HSPA13,HSPB8,D NAJB6 Pathway 326 G-Protein Coupled 3,34E- 2,79E-02 7/251 (3%) 244/251 (97%) HTR2B,MAPK1,NPY1R,P Receptor Signaling 01 DE12,KRAS,STAT3,MAP2 K1

327 Role of JAK1, JAK2 3,34E- 4,17E-02 1/24 (4%) 23/24 (96%) STAT3 and TYK2 in 01 Interferon Signaling 328 Estrogen-mediated 3,34E- 4,17E-02 1/24 (4%) 23/24 (96%) TFDP1 S-phase Entry 01

329 Bupropion 3,34E- 4,17E-02 1/24 (4%) 23/24 (96%) CYP2U1 Degradation 01 330 Thyroid Hormone 3,34E- 4,17E-02 1/24 (4%) 23/24 (96%) SULT1A1 Metabolism II (via 01 Conjugation and/or Degradation)

331 Estrogen- 3,32E- 3,28E-02 2/61 (3%) 59/61 (97%) MAPK1,KRAS Dependent Breast 01 Cancer Signaling

332 Acetone 3,21E- 4E-02 1/25 (4%) 24/25 (96%) CYP2U1 Degradation I (to 01 Methylglyoxal) 333 Antiproliferative 3,09E- 3,85E-02 1/26 (4%) 25/26 (96%) MAPK1 Role of TOB in T 01 Cell Signaling 334 D-myo-inositol 3,09E- 3,85E-02 1/26 (4%) 25/26 (96%) PIP4K2A (1,4,5)- 01 Trisphosphate Biosynthesis 335 Corticotropin 2,96E- 2,86E-02 3/105 (3%) 102/105 (97%) MAPK1,ARPC5,MAP2K1 Releasing 01 Hormone Signaling

336 Melatonin 2,82E- 2,94E-02 2/68 (3%) 66/68 (97%) MAPK1,MAP2K1 Signaling 01 337 Role of 2,77E- 3,45E-02 1/29 (3%) 28/29 (97%) RAC1 p14/p19ARF in 01 Tumor Suppression

338 Gustation Pathway 2,75E- 2,75E-02 3/109 (3%) 106/109 (97%) GNB1,PDE12,GNG2 01 339 Ethanol 2,67E- 3,33E-02 1/30 (3%) 29/30 (97%) ALDH1A3 Degradation II 01 340 Fatty Acid β- 2,67E- 3,33E-02 1/30 (3%) 29/30 (97%) ACSL5 oxidation I 01 341 Inhibition of 2,48E- 3,12E-02 1/32 (3%) 31/32 (97%) MAPK1 Angiogenesis by 01 TSP1 342 TWEAK Signaling 2,4E-01 3,03E-02 1/33 (3%) 32/33 (97%) BID

343 Triacylglycerol 2,4E-01 3,03E-02 1/33 (3%) 32/33 (97%) LCLAT1 Biosynthesis 344 Noradrenaline and 2,4E-01 3,03E-02 1/33 (3%) 32/33 (97%) ALDH1A3 Adrenaline Degradation 345 Antigen 2,4E-01 3,03E-02 1/33 (3%) 32/33 (97%) MR1 Presentation Pathway 346 HER-2 Signaling in 2,34E- 2,63E-02 2/76 (3%) 74/76 (97%) KRAS,ITGB5 Breast Cancer 01 347 Dopamine 2,29E- 2,6E-02 2/77 (3%) 75/77 (97%) PPP1R12A,PPP2R5C Receptor Signaling 01

348 Cell Cycle 2,24E- 2,86E-02 1/35 (3%) 34/35 (97%) PPP2R5C Regulation by BTG 01 Family Proteins

349 tRNA Splicing 2,24E- 2,86E-02 1/35 (3%) 34/35 (97%) PDE12 01 350 autophagy 2,17E- 2,78E-02 1/36 (3%) 35/36 (97%) ATG12 01 351 April Mediated 2,03E- 2,63E-02 1/38 (3%) 37/38 (97%) MAPK1 Signaling 01 352 tRNA Charging 2,03E- 2,63E-02 1/38 (3%) 37/38 (97%) LARS 01 353 Inhibition of Matrix 2,03E- 2,63E-02 1/38 (3%) 37/38 (97%) ADAM12 Metalloproteases 01 Supplementary data S8B Adipose tissue - Pathway analysis of consistently up- or downregulated transcripts between the co-twins, n=12/14 co-twins Downregulated in the heavier co-twin Ingenuity Canonical -log(p- Ratio Overlaps No overlap Molecules Pathways value) with dataset with dataset

1 Role of CHK Proteins in Cell 2,71E00 1,09E-01 6/55 (11%) 49/55 (89%) RFC4,PPP2R4,RAD17,PPP Cycle Checkpoint Control 2R5C,BRCA1,ATM

2 L-cysteine Degradation I 2,48E00 5E-01 2/4 (50%) 2/4 (50%) GOT1,CDO1 3 DNA Double-Strand Break 2,39E00 2,14E-01 3/14 (21%) 11/14 (79%) GEN1,BRCA1,ATM Repair by Homologous Recombination

4 DNA damage-induced 14-3- 2E00 1,58E-01 3/19 (16%) 16/19 (84%) RAD17,BRCA1,ATM 3σ Signaling 5 Dopamine Receptor 1,99E00 7,79E-02 6/77 (8%) 71/77 (92%) GCH1,PPP2R4,NCS1,PPP Signaling 2R5C,ADCY10,PPP1CA 6 Sucrose Degradation V 1,84E00 2,5E-01 2/8 (25%) 6/8 (75%) KHK,ALDOB (Mammalian) 7 Regulation of eIF4 and 1,71E00 5,71E-02 8/140 (6%) 132/140 EIF3G,PPP2R4,EIF2B3,PP p70S6K Signaling (94%) P2R5C,RPS11,EIF4E,EIF2S 2,ATM 8 L-dopachrome Biosynthesis 1,62E00 1E00 1/1 (100%) 0/1 (0%) TYR

9 Superpathway of Cholesterol 1,58E00 1,11E-01 3/27 (11%) 24/27 (89%) PMVK,HADHB,MSMO1 Biosynthesis 10 Telomerase Signaling 1,56E00 6,25E-02 6/96 (6%) 90/96 (94%) HDAC4,HDAC8,PPP2R4,D KC1,PPP2R5C,ATM 11 mTOR Signaling 1,52E00 4,97E-02 9/181 (5%) 172/181 PLD4,EIF3G,PPP2R4,RHO (95%) C,PPP2R5C,RHOH,RPS11, EIF4E,ATM 12 Mevalonate Pathway I 1,49E00 1,67E-01 2/12 (17%) 10/12 (83%) PMVK,HADHB

13 Cyclins and Cell Cycle 1,43E00 6,49E-02 5/77 (6%) 72/77 (94%) HDAC4,HDAC8,PPP2R4,P Regulation PP2R5C,ATM 14 Phenylalanine Degradation 1,37E00 1,43E-01 2/14 (14%) 12/14 (86%) GOT1,SLC27A3 IV (Mammalian, via Side Chain)

15 Choline Degradation I 1,33E00 5E-01 1/2 (50%) 1/2 (50%) CHDH 16 Taurine Biosynthesis 1,33E00 5E-01 1/2 (50%) 1/2 (50%) CDO1 17 L-cysteine Degradation III 1,33E00 5E-01 1/2 (50%) 1/2 (50%) GOT1 18 EIF2 Signaling 1,29E00 4,73E-02 8/169 (5%) 161/169 EIF3G,EIF2B3,RPL10,PPP (95%) 1CA,RPS11,EIF4E,EIF2S2, ATM 19 TR/RXR Activation 1,27E00 5,88E-02 5/85 (6%) 80/85 (94%) LDLR,NXPH2,NCOA6,NCO A3,ATM 20 Superpathway of 1,26E00 1,25E-01 2/16 (13%) 14/16 (88%) PMVK,HADHB Geranylgeranyldiphosphate Biosynthesis I (via Mevalonate) 21 Gαq Signaling 1,22E00 4,83E-02 7/145 (5%) 138/145 PLD4,RGS2,RHOC,CALCR, (95%) GNG5,RHOH,ATM 22 tRNA Charging 1,21E00 7,89E-02 3/38 (8%) 35/38 (92%) YARS2,IARS2,FARS2

23 Mitotic Roles of Polo-Like 1,19E00 6,35E-02 4/63 (6%) 59/63 (94%) ANAPC2,PPP2R4,PPP2R5 Kinase C,ANAPC13 24 Valine Degradation I 1,17E00 1,11E-01 2/18 (11%) 16/18 (89%) BCKDHA,HADHB

25 Diphthamide Biosynthesis 1,15E00 3,33E-01 1/3 (33%) 2/3 (67%) EEF2

26 Tetrahydrobiopterin 1,15E00 3,33E-01 1/3 (33%) 2/3 (67%) GCH1 Biosynthesis I 27 Tetrahydrobiopterin 1,15E00 3,33E-01 1/3 (33%) 2/3 (67%) GCH1 Biosynthesis II 28 Glutamate Degradation II 1,15E00 3,33E-01 1/3 (33%) 2/3 (67%) GOT1

29 4-aminobutyrate 1,15E00 3,33E-01 1/3 (33%) 2/3 (67%) ALDH5A1 Degradation I 30 N-acetylglucosamine 1,15E00 3,33E-01 1/3 (33%) 2/3 (67%) GNPDA2 Degradation I 31 Aspartate Biosynthesis 1,15E00 3,33E-01 1/3 (33%) 2/3 (67%) GOT1

32 GADD45 Signaling 1,13E00 1,05E-01 2/19 (11%) 17/19 (89%) BRCA1,ATM

33 Tryptophan Degradation III 1,09E00 1E-01 2/20 (10%) 18/20 (90%) HADHB,IDO1 (Eukaryotic) 34 Phospholipase C Signaling 1,08E00 4,09E-02 9/220 (4%) 211/220 PLD4,HDAC4,PLA2G2D,H (96%) DAC8,RHOC,PLA2G5,ADC Y10,GNG5,RHOH 35 Insulin Receptor Signaling 1,07E00 4,72E-02 6/127 (5%) 121/127 LIPE,EIF2B3,PPP1CA,PTP (95%) RF,EIF4E,ATM 36 p53 Signaling 1,06E00 5,1E-02 5/98 (5%) 93/98 (95%) SNAI2,PML,BRCA1,ATM, TP53I3 37 Oxidative Phosphorylation 1,06E00 5,1E-02 5/98 (5%) 93/98 (95%) NDUFV1,NDUFB9,NDUFV 3,NDUFB7,NDUFS2

38 Branched-chain α-keto acid 1,03E00 2,5E-01 1/4 (25%) 3/4 (75%) BCKDHA Dehydrogenase Complex

39 Eumelanin Biosynthesis 1,03E00 2,5E-01 1/4 (25%) 3/4 (75%) TYR 40 α-tocopherol Degradation 1,03E00 2,5E-01 1/4 (25%) 3/4 (75%) CYP4A11

41 N-acetylglucosamine 1,03E00 2,5E-01 1/4 (25%) 3/4 (75%) GNPDA2 Degradation II 42 Cardiac β-adrenergic 1,01E00 4,55E-02 6/132 (5%) 126/132 AKAP13,PPP2R4,PPP2R5 Signaling (95%) C,ADCY10,PPP1CA,GNG5 43 Creatine-phosphate 9,43E-01 2E-01 1/5 (20%) 4/5 (80%) CKB Biosynthesis 44 Glutamate Degradation III 9,43E-01 2E-01 1/5 (20%) 4/5 (80%) ALDH5A1 (via 4-aminobutyrate) 45 Phospholipases 8,93E-01 5,77E-02 3/52 (6%) 49/52 (94%) PLD4,PLA2G2D,PLA2G5

46 AMPK Signaling 8,76E-01 3,95E-02 7/177 (4%) 170/177 PPP2R4,EEF2,CHRNB1,LI (96%) PE,PPP2R5C,PFKFB2,AT M 47 Sphingosine and Sphingosine- 8,69E-01 1,67E-01 1/6 (17%) 5/6 (83%) SGPP2 1-phosphate Metabolism

48 Zymosterol Biosynthesis 8,69E-01 1,67E-01 1/6 (17%) 5/6 (83%) MSMO1

49 Production of Nitric Oxide 8,58E-01 3,91E-02 7/179 (4%) 172/179 PPP2R4,APOF,RHOC,PPP and Reactive Oxygen Species (96%) 2R5C,PPP1CA,RHOH,AT M in Macrophages

50 Melanocyte Development 8,47E-01 4,76E-02 4/84 (5%) 80/84 (95%) KITLG,TYR,ADCY10,ATM and Pigmentation Signaling

51 HIPPO signaling 8,34E-01 4,71E-02 4/85 (5%) 81/85 (95%) SAV1,PPP2R4,PPP2R5C,P PP1CA 52 Glutamate Receptor 8,24E-01 5,36E-02 3/56 (5%) 53/56 (95%) SLC1A3,GNG5,GRINA Signaling 53 ERK/MAPK Signaling 8,23E-01 3,83E-02 7/183 (4%) 176/183 PLA2G2D,PPP2R4,PLA2G (96%) 5,PPP2R5C,PPP1CA,EIF4E ,ATM 54 Glioma Invasiveness 8,07E-01 5,26E-02 3/57 (5%) 54/57 (95%) RHOC,RHOH,ATM Signaling 55 Tryptophan Degradation to 2- 8,07E-01 1,43E-01 1/7 (14%) 6/7 (86%) IDO1 amino-3-carboxymuconate Semialdehyde

56 Ketolysis 8,07E-01 1,43E-01 1/7 (14%) 6/7 (86%) HADHB

57 Aspartate Degradation II 8,07E-01 1,43E-01 1/7 (14%) 6/7 (86%) GOT1

58 Fatty Acid β-oxidation I 7,94E-01 6,67E-02 2/30 (7%) 28/30 (93%) HADHB,SLC27A3

59 Breast Cancer Regulation by 7,81E-01 3,72E-02 7/188 (4%) 181/188 CAMK2A,PPP2R4,PPP2R5 Stathmin1 (96%) C,ADCY10,PPP1CA,GNG5 ,ATM 60 ATM Signaling 7,76E-01 5,08E-02 3/59 (5%) 56/59 (95%) CBX5,BRCA1,ATM

61 Eicosanoid Signaling 7,76E-01 5,08E-02 3/59 (5%) 56/59 (95%) PTGFR,PLA2G2D,PLA2G5

62 MIF-mediated Glucocorticoid 7,71E-01 6,45E-02 2/31 (6%) 29/31 (94%) PLA2G2D,PLA2G5 Regulation

63 Superpathway of Methionine 7,71E-01 6,45E-02 2/31 (6%) 29/31 (94%) GOT1,CDO1 Degradation 64 Hereditary Breast Cancer 7,34E-01 3,97E-02 5/126 (4%) 121/126 HDAC4,RFC4,HDAC8,BRC Signaling (96%) A1,ATM 65 Cell Cycle: G1/S Checkpoint 7,18E-01 4,76E-02 3/63 (5%) 60/63 (95%) HDAC4,HDAC8,ATM Regulation 66 UDP-N-acetyl-D- 7,08E-01 1,11E-01 1/9 (11%) 8/9 (89%) GNPDA2 galactosamine Biosynthesis II

67 Folate Transformations I 7,08E-01 1,11E-01 1/9 (11%) 8/9 (89%) MTHFR

68 Tight Junction Signaling 6,98E-01 3,66E-02 6/164 (4%) 158/164 PPP2R4,HSF1,PPP2R5C,C (96%) LDN2,SPTAN1,GOSR2 69 Cell Cycle Regulation by BTG 6,9E-01 5,71E-02 2/35 (6%) 33/35 (94%) PPP2R4,PPP2R5C Family Proteins 70 CDK5 Signaling 6,82E-01 4,08E-02 4/98 (4%) 94/98 (96%) PPP2R4,PPP2R5C,ADCY1 0,PPP1CA 71 Calcium Signaling 6,74E-01 3,59E-02 6/167 (4%) 161/167 CHRNA1,HDAC4,CAMK2 (96%) A,HDAC8,CHRNB1,GRINA 72 Aryl Hydrocarbon Receptor 6,69E-01 3,76E-02 5/133 (4%) 128/133 TYR,GSTA1,ALDH5A1,NC Signaling (96%) OA3,ATM 73 Ketogenesis 6,67E-01 1E-01 1/10 (10%) 9/10 (90%) HADHB 74 Role of NFAT in Cardiac 6,22E-01 3,45E-02 6/174 (3%) 168/174 HDAC4,CAMK2A,HDAC8, Hypertrophy (97%) ADCY10,GNG5,ATM 75 MIF Regulation of Innate 6,21E-01 5,13E-02 2/39 (5%) 37/39 (95%) PLA2G2D,PLA2G5 Immunity 76 Transcriptional Regulatory 6,05E-01 5E-02 2/40 (5%) 38/40 (95%) ZIC3,MEIS1 Network in Embryonic Stem Cells 77 Sphingosine-1-phosphate 6,04E-01 3,77E-02 4/106 (4%) 102/106 RHOC,ADCY10,RHOH,AT Signaling (96%) M 78 Assembly of RNA Polymerase 5,98E-01 8,33E-02 1/12 (8%) 11/12 (92%) GTF3C5 III Complex 79 Hematopoiesis from 5,98E-01 8,33E-02 1/12 (8%) 11/12 (92%) KITLG Multipotent Stem Cells 80 Glutaryl-CoA Degradation 5,98E-01 8,33E-02 1/12 (8%) 11/12 (92%) HADHB

81 Androgen Biosynthesis 5,98E-01 8,33E-02 1/12 (8%) 11/12 (92%) SRD5A2

82 Ubiquinol-10 Biosynthesis 5,98E-01 8,33E-02 1/12 (8%) 11/12 (92%) BCKDHA (Eukaryotic) 83 Serotonin Receptor Signaling 5,9E-01 4,88E-02 2/41 (5%) 39/41 (95%) GCH1,ADCY10

84 VEGF Family Ligand-Receptor 5,84E-01 4,05E-02 3/74 (4%) 71/74 (96%) PLA2G2D,PLA2G5,ATM Interactions 85 Sperm Motility 5,77E-01 3,67E-02 4/109 (4%) 105/109 ATP1A4,PLA2G2D,PLA2G (96%) 5,ADCY10 86 ILK Signaling 5,74E-01 3,31E-02 6/181 (3%) 175/181 SNAI2,PPP2R4,RHOC,PPP (97%) 2R5C,RHOH,ATM 87 Cardiac Hypertrophy 5,72E-01 3,21E-02 7/218 (3%) 211/218 RHOC,EIF2B3,ADCY10,G Signaling (97%) NG5,RHOH,EIF4E,ATM 88 Protein Kinase A Signaling 5,72E-01 2,99E-02 11/368 (3%) 357/368 ANAPC2,AKAP13,DUSP3, (97%) CAMK2A,PHKG2,LIPE,AD CY10,PPP1CA,GNG5,ANA PC13,PTPRF 89 Fatty Acid Activation 5,68E-01 7,69E-02 1/13 (8%) 12/13 (92%) SLC27A3

90 NAD biosynthesis II (from 5,68E-01 7,69E-02 1/13 (8%) 12/13 (92%) IDO1 tryptophan) 91 Choline Biosynthesis III 5,68E-01 7,69E-02 1/13 (8%) 12/13 (92%) PLD4

92 Cholesterol Biosynthesis I 5,68E-01 7,69E-02 1/13 (8%) 12/13 (92%) MSMO1

93 Cholesterol Biosynthesis II 5,68E-01 7,69E-02 1/13 (8%) 12/13 (92%) MSMO1 (via 24,25-dihydrolanosterol)

94 Cholesterol Biosynthesis III 5,68E-01 7,69E-02 1/13 (8%) 12/13 (92%) MSMO1 (via Desmosterol) 95 Acute Myeloid Leukemia 5,63E-01 3,95E-02 3/76 (4%) 73/76 (96%) KITLG,PML,ATM Signaling 96 CCR3 Signaling in Eosinophils 5,6E-01 3,6E-02 4/111 (4%) 107/111 PLA2G2D,PLA2G5,GNG5, (96%) ATM 97 Superpathway of Inositol 5,54E-01 3,26E-02 6/184 (3%) 178/184 PLD4,PPP2R4,PPP1CA,P Phosphate Compounds (97%) MPCA,PTPRF,ATM 98 Role of BRCA1 in DNA 5,52E-01 3,9E-02 3/77 (4%) 74/77 (96%) RFC4,BRCA1,ATM Damage Response 99 DNA Double-Strand Break 5,41E-01 7,14E-02 1/14 (7%) 13/14 (93%) ATM Repair by Non-Homologous End Joining 100 nNOS Signaling in Skeletal 5,41E-01 7,14E-02 1/14 (7%) 13/14 (93%) CHRNA1 Muscle Cells 101 Isoleucine Degradation I 5,41E-01 7,14E-02 1/14 (7%) 13/14 (93%) HADHB

102 Thrombin Signaling 5,36E-01 3,21E-02 6/187 (3%) 181/187 CAMK2A,RHOC,ADCY10, (97%) GNG5,RHOH,ATM 103 Ceramide Signaling 5,33E-01 3,8E-02 3/79 (4%) 76/79 (96%) PPP2R4,PPP2R5C,ATM 104 Huntington's Disease 5,31E-01 3,11E-02 7/225 (3%) 218/225 HDAC4,HDAC8,PENK,HA Signaling (97%) P1,GOSR2,GNG5,ATM 105 CXCR4 Signaling 5,3E-01 3,31E-02 5/151 (3%) 146/151 RHOC,ADCY10,GNG5,RH (97%) OH,ATM 106 nNOS Signaling in Neurons 5,2E-01 4,35E-02 2/46 (4%) 44/46 (96%) CAMK2A,GRINA

107 Gαi Signaling 5,12E-01 3,42E-02 4/117 (3%) 113/117 RAP1GAP,ADCY10,ADOR (97%) A1,GNG5 108 HMGB1 Signaling 5,05E-01 3,39E-02 4/118 (3%) 114/118 HMGB1,RHOC,RHOH,AT (97%) M 109 p70S6K Signaling 5,05E-01 3,39E-02 4/118 (3%) 114/118 PPP2R4,EEF2,PPP2R5C,A (97%) TM 110 CTLA4 Signaling in Cytotoxic 4,95E-01 3,61E-02 3/83 (4%) 80/83 (96%) PPP2R4,PPP2R5C,ATM T Lymphocytes 111 RAN Signaling 4,93E-01 6,25E-02 1/16 (6%) 15/16 (94%) RCC1

112 Mismatch Repair in 4,93E-01 6,25E-02 1/16 (6%) 15/16 (94%) RFC4 Eukaryotes 113 Dopamine-DARPP32 4,91E-01 3,18E-02 5/157 (3%) 152/157 PPP2R4,PPP2R5C,ADCY1 Feedback in cAMP Signaling (97%) 0,PPP1CA,GRINA

114 Cell Cycle: G2/M DNA 4,84E-01 4,08E-02 2/49 (4%) 47/49 (96%) BRCA1,ATM Damage Checkpoint Regulation 115 Mitochondrial Dysfunction 4,78E-01 3,14E-02 5/159 (3%) 154/159 NDUFV1,NDUFB9,NDUFV (97%) 3,NDUFB7,NDUFS2 116 α-Adrenergic Signaling 4,78E-01 3,53E-02 3/85 (4%) 82/85 (96%) PHKG2,ADCY10,GNG5

117 γ-linolenate Biosynthesis II 4,71E-01 5,88E-02 1/17 (6%) 16/17 (94%) SLC27A3 (Animals) 118 Mitochondrial L-carnitine 4,71E-01 5,88E-02 1/17 (6%) 16/17 (94%) SLC27A3 Shuttle Pathway 119 D-myo-inositol (1,4,5)- 4,52E-01 5,56E-02 1/18 (6%) 17/18 (94%) PMPCA trisphosphate Degradation

120 Semaphorin Signaling in 4,5E-01 3,85E-02 2/52 (4%) 50/52 (96%) RHOC,RHOH Neurons 121 UVB-Induced MAPK Signaling 4,5E-01 3,85E-02 2/52 (4%) 50/52 (96%) EIF4E,ATM

122 VEGF Signaling 4,45E-01 3,37E-02 3/89 (3%) 86/89 (97%) EIF2B3,EIF2S2,ATM

123 Endothelin-1 Signaling 4,42E-01 3,03E-02 5/165 (3%) 160/165 PLD4,PLA2G2D,PLA2G5, (97%) ADCY10,ATM 124 1D-myo-inositol 4,33E-01 5,26E-02 1/19 (5%) 18/19 (95%) PMPCA Hexakisphosphate Biosynthesis II (Mammalian)

125 D-myo-inositol (1,3,4)- 4,33E-01 5,26E-02 1/19 (5%) 18/19 (95%) PMPCA trisphosphate Biosynthesis

126 Chronic Myeloid Leukemia 4,22E-01 3,26E-02 3/92 (3%) 89/92 (97%) HDAC4,HDAC8,ATM Signaling 127 Antioxidant Action of 4,22E-01 3,26E-02 3/92 (3%) 89/92 (97%) PLD4,PLA2G2D,PLA2G5 Vitamin C 128 Xenobiotic Metabolism 4,17E-01 2,82E-02 7/248 (3%) 241/248 HDAC4,CAMK2A,PPP2R4, Signaling (97%) GSTA1,PPP2R5C,ALDH5A 1,ATM 129 Lipid Antigen Presentation 4,15E-01 5E-02 1/20 (5%) 19/20 (95%) CD1A by CD1 130 Maturity Onset Diabetes of 4,15E-01 5E-02 1/20 (5%) 19/20 (95%) ALDOB Young (MODY) Signaling

131 Actin Nucleation by ARP- 4,1E-01 3,57E-02 2/56 (4%) 54/56 (96%) RHOC,RHOH WASP Complex 132 Synaptic Long Term 4,04E-01 3,01E-02 4/133 (3%) 129/133 PLA2G2D,PPP2R4,PLA2G Depression (97%) 5,PPP2R5C 133 G-Protein Coupled Receptor 4,04E-01 2,79E-02 7/251 (3%) 244/251 RGS2,CAMK2A,RAP1GAP Signaling (97%) ,CALCR,ADCY10,ADORA1, ATM 134 cAMP-mediated signaling 4,01E-01 2,83E-02 6/212 (3%) 206/212 AKAP13,RGS2,CAMK2A,R (97%) AP1GAP,ADCY10,ADORA 1 135 D-myo-inositol-5-phosphate 3,87E-01 2,94E-02 4/136 (3%) 132/136 PLD4,PPP2R4,PPP1CA,PT Metabolism (97%) PRF 136 Glutathione-mediated 3,84E-01 4,55E-02 1/22 (5%) 21/22 (95%) GSTA1 Detoxification 137 Glycolysis I 3,84E-01 4,55E-02 1/22 (5%) 21/22 (95%) ALDOB

138 3-phosphoinositide 3,81E-01 2,92E-02 4/137 (3%) 133/137 PPP2R4,MTMR1,PPP1CA, Degradation (97%) PTPRF 139 Antiproliferative Role of 3,74E-01 3,33E-02 2/60 (3%) 58/60 (97%) GNG5,ATM Somatostatin Receptor 2 140 Neuropathic Pain Signaling In 3,73E-01 3,03E-02 3/99 (3%) 96/99 (97%) CAMK2A,GRINA,ATM Dorsal Horn Neurons

141 phagosome formation 3,73E-01 3,03E-02 3/99 (3%) 96/99 (97%) RHOC,RHOH,ATM

142 Gluconeogenesis I 3,69E-01 4,35E-02 1/23 (4%) 22/23 (96%) ALDOB

143 GM-CSF Signaling 3,66E-01 3,28E-02 2/61 (3%) 59/61 (97%) CAMK2A,ATM

144 Tumoricidal Function of 3,55E-01 4,17E-02 1/24 (4%) 23/24 (96%) M6PR Hepatic Natural Killer Cells

145 Triacylglycerol Degradation 3,55E-01 4,17E-02 1/24 (4%) 23/24 (96%) LIPE

146 Superpathway of D-myo- 3,55E-01 4,17E-02 1/24 (4%) 23/24 (96%) PMPCA inositol (1,4,5)-trisphosphate Metabolism

147 IL-8 Signaling 3,5E-01 2,73E-02 5/183 (3%) 178/183 PLD4,RHOC,GNG5,RHOH, (97%) ATM 148 Hypoxia Signaling in the 3,5E-01 3,17E-02 2/63 (3%) 61/63 (97%) COPS5,ATM Cardiovascular System 149 Role of MAPK Signaling in 3,42E-01 3,12E-02 2/64 (3%) 62/64 (97%) PLA2G2D,PLA2G5 the Pathogenesis of Influenza 150 Fc Epsilon RI Signaling 3,36E-01 2,86E-02 3/105 (3%) 102/105 PLA2G2D,PLA2G5,ATM (97%) 151 D-myo-inositol (1,4,5)- 3,3E-01 3,85E-02 1/26 (4%) 25/26 (96%) PLD4 Trisphosphate Biosynthesis

152 Gαs Signaling 3,3E-01 2,83E-02 3/106 (3%) 103/106 RGS2,ADCY10,GNG5 (97%) 153 3-phosphoinositide 3,29E-01 2,72E-02 4/147 (3%) 143/147 PPP2R4,PPP1CA,PTPRF,A Biosynthesis (97%) TM 154 GABA Receptor Signaling 3,27E-01 3,03E-02 2/66 (3%) 64/66 (97%) ADCY10,ALDH5A1

155 Colorectal Cancer Metastasis 3,25E-01 2,61E-02 6/230 (3%) 224/230 ARRB1,RHOC,ADCY10,G Signaling (97%) NG5,RHOH,ATM 156 Role of Tissue Factor in 3,24E-01 2,8E-02 3/107 (3%) 104/107 ARRB1,EIF4E,ATM Cancer (97%) 157 Signaling by Rho Family 3,21E-01 2,6E-02 6/231 (3%) 225/231 SEPT8,CDH7,RHOC,GNG5 GTPases (97%) ,RHOH,ATM 158 Tec Kinase Signaling 3,14E-01 2,67E-02 4/150 (3%) 146/150 RHOC,GNG5,RHOH,ATM (97%) 159 Gustation Pathway 3,13E-01 2,75E-02 3/109 (3%) 106/109 P2RY10,ADCY10,GNG5 (97%) 160 Melatonin Signaling 3,13E-01 2,94E-02 2/68 (3%) 66/68 (97%) CAMK2A,RORA

161 Role of p14/p19ARF in 2,97E-01 3,45E-02 1/29 (3%) 28/29 (97%) ATM Tumor Suppression 162 FLT3 Signaling in 2,93E-01 2,82E-02 2/71 (3%) 69/71 (97%) EIF4E,ATM Hematopoietic Progenitor Cells 163 Retinol Biosynthesis 2,87E-01 3,33E-02 1/30 (3%) 29/30 (97%) LIPE

164 Ethanol Degradation II 2,87E-01 3,33E-02 1/30 (3%) 29/30 (97%) DHRS2

165 Leptin Signaling in Obesity 2,8E-01 2,74E-02 2/73 (3%) 71/73 (97%) ADCY10,ATM

166 Synaptic Long Term 2,78E-01 2,59E-02 3/116 (3%) 113/116 CAMK2A,PPP1CA,GRINA Potentiation (97%) 167 G Protein Signaling Mediated 2,77E-01 3,23E-02 1/31 (3%) 30/31 (97%) GNG5 by Tubby 168 Role of Pattern Recognition 2,68E-01 2,54E-02 3/118 (3%) 115/118 OAS1,IRF7,ATM Receptors in Recognition of (97%) Bacteria and Viruses

169 Atherosclerosis Signaling 2,68E-01 2,54E-02 3/118 (3%) 115/118 PLA2G2D,APOF,PLA2G5 (97%) 170 P2Y Purigenic Receptor 2,68E-01 2,54E-02 3/118 (3%) 115/118 ADCY10,GNG5,ATM Signaling Pathway (97%) 171 D-myo-inositol (1,4,5,6)- 2,59E-01 2,5E-02 3/120 (3%) 117/120 PPP2R4,PPP1CA,PTPRF Tetrakisphosphate (98%) Biosynthesis 172 D-myo-inositol (3,4,5,6)- 2,59E-01 2,5E-02 3/120 (3%) 117/120 PPP2R4,PPP1CA,PTPRF tetrakisphosphate (98%) Biosynthesis 173 PI3K/AKT Signaling 2,59E-01 2,5E-02 3/120 (3%) 117/120 PPP2R4,PPP2R5C,EIF4E (98%) 174 Circadian Rhythm Signaling 2,59E-01 3,03E-02 1/33 (3%) 32/33 (97%) GRINA 175 Hematopoiesis from 2,59E-01 3,03E-02 1/33 (3%) 32/33 (97%) KITLG Pluripotent Stem Cells 176 Triacylglycerol Biosynthesis 2,59E-01 3,03E-02 1/33 (3%) 32/33 (97%) DGAT1

177 Stearate Biosynthesis I 2,59E-01 3,03E-02 1/33 (3%) 32/33 (97%) SLC27A3 (Animals) 178 Noradrenaline and 2,59E-01 3,03E-02 1/33 (3%) 32/33 (97%) DHRS2 Adrenaline Degradation 179 VDR/RXR Activation 2,57E-01 2,6E-02 2/77 (3%) 75/77 (97%) IGFBP6,NCOA3 180 PPARα/RXRα Activation 2,52E-01 2,42E-02 4/165 (2%) 161/165 NCOA6,ADCY10,MED24, (98%) NCOA3 181 IL-9 Signaling 2,51E-01 2,94E-02 1/34 (3%) 33/34 (97%) ATM

182 GPCR-Mediated Nutrient 2,41E-01 2,5E-02 2/80 (3%) 78/80 (98%) ADCY10,GNG5 Sensing in Enteroendocrine Cells 183 Interferon Signaling 2,35E-01 2,78E-02 1/36 (3%) 35/36 (97%) OAS1

184 Docosahexaenoic Acid (DHA) 2,13E-01 2,56E-02 1/39 (3%) 38/39 (97%) ATM Signaling 185 Role of RIG1-like Receptors 2,01E-01 2,44E-02 1/41 (2%) 40/41 (98%) IRF7 in Antiviral Innate Immunity

186 FcγRIIB Signaling in B 2,01E-01 2,44E-02 1/41 (2%) 40/41 (98%) ATM Lymphocytes

Upregulated in the heavier co-twin Ingenuity Canonical -log(p- Ratio Overlaps No overlap Molecules Pathways value) with dataset with dataset

1 14-3-3-mediated Signaling 2,77E00 5,26E-02 6/114 (5%) 108/114 TUBA1B,TRAF2,TUBA3C/ (95%) TUBA3D,PLCG1,H2BFM,P RKD1 2 Hepatic Cholestasis 2,07E00 3,8E-02 6/158 (4%) 152/158 MAP4K2,TRAF2,IL3,NR5A (96%) 2,IL25,PRKD1 3 NF-κB Activation by Viruses 2,05E00 5,48E-02 4/73 (5%) 69/73 (95%) TRAF2,IKBKAP,PRKD1,CR 2 4 HER-2 Signaling in Breast 1,99E00 5,26E-02 4/76 (5%) 72/76 (95%) CCNE2,PLCG1,H2BFM,PR Cancer KD1 5 Assembly of RNA Polymerase 1,74E00 6E-02 3/50 (6%) 47/50 (94%) TAF4B,GTF2B,POLR2J II Complex 6 Role of Cytokines in 1,7E00 5,77E-02 3/52 (6%) 49/52 (94%) IL3,IFNL1,IL25 Mediating Communication between Immune Cells

7 Lipid Antigen Presentation 1,69E00 1E-01 2/20 (10%) 18/20 (90%) CD1B,AP2A2 by CD1 8 GDP-L-fucose Biosynthesis I 1,66E00 5E-01 1/2 (50%) 1/2 (50%) GMDS (from GDP-D-mannose) 9 N-acetylglucosamine 1,48E00 3,33E-01 1/3 (33%) 2/3 (67%) GNPDA1 Degradation I 10 Androgen Signaling 1,47E00 3,64E-02 4/110 (4%) 106/110 GTF2B,GNA11,POLR2J,PR (96%) KD1 11 CD40 Signaling 1,47E00 4,69E-02 3/64 (5%) 61/64 (95%) TRAF2,CD40LG,IKBKAP

12 GABA Receptor Signaling 1,43E00 4,55E-02 3/66 (5%) 63/66 (95%) KCNN3,GABRA5,AP2A2

13 Synaptic Long Term 1,39E00 3,45E-02 4/116 (3%) 112/116 PPP1R3D,GNA11,PLCG1, Potentiation (97%) PRKD1 14 CREB Signaling in Neurons 1,39E00 2,96E-02 5/169 (3%) 164/169 GTF2B,GNA11,POLR2J,PL (97%) CG1,PRKD1 15 Role of Pattern Recognition 1,37E00 3,39E-02 4/118 (3%) 114/118 IL3,NLRP3,IL25,PRKD1 Receptors in Recognition of (97%) Bacteria and Viruses

16 Ceramide Degradation 1,36E00 2,5E-01 1/4 (25%) 3/4 (75%) ASAH1 17 N-acetylglucosamine 1,36E00 2,5E-01 1/4 (25%) 3/4 (75%) GNPDA1 Degradation II 18 4-1BB Signaling in T 1,34E00 6,45E-02 2/31 (6%) 29/31 (94%) TRAF2,IKBKAP Lymphocytes 19 Cellular Effects of Sildenafil 1,31E00 3,23E-02 4/124 (3%) 120/124 KCNN3,PLCG1,PDE5A,MY (Viagra) (97%) LK 20 TWEAK Signaling 1,29E00 6,06E-02 2/33 (6%) 31/33 (94%) TRAF2,BAG4

21 Protein Kinase A Signaling 1,27E00 2,17E-02 8/368 (2%) 360/368 ENPP6,PPP1R3D,PLCG1,P (98%) DE5A,MYLK,H2BFM,PTC H2,PRKD1 22 tRNA Splicing 1,24E00 5,71E-02 2/35 (6%) 33/35 (94%) ENPP6,PDE5A

23 Breast Cancer Regulation by 1,23E00 2,66E-02 5/188 (3%) 183/188 TUBA1B,CCNE2,PPP1R3D Stathmin1 (97%) ,TUBA3C/TUBA3D,PRKD1 24 GPCR-Mediated Nutrient 1,23E00 3,75E-02 3/80 (4%) 77/80 (96%) GNA11,PLCG1,PRKD1 Sensing in Enteroendocrine Cells 25 Sphingosine and Sphingosine- 1,19E00 1,67E-01 1/6 (17%) 5/6 (83%) ASAH1 1-phosphate Metabolism

26 B Cell Activating Factor 1,14E00 5E-02 2/40 (5%) 38/40 (95%) TRAF2,IKBKAP Signaling 27 G Beta Gamma Signaling 1,13E00 3,41E-02 3/88 (3%) 85/88 (97%) GNA11,PLCG1,PRKD1

28 Pregnenolone Biosynthesis 1,12E00 1,43E-01 1/7 (14%) 6/7 (86%) MICAL2

29 Virus Entry via Endocytic 1,12E00 3,37E-02 3/89 (3%) 86/89 (97%) PLCG1,AP2A2,PRKD1 Pathways 30 SAPK/JNK Signaling 1,12E00 3,37E-02 3/89 (3%) 86/89 (97%) MAP4K2,TRAF2,MAP4K1

31 Glucocorticoid Receptor 1,09E00 2,22E-02 6/270 (2%) 264/270 TAF4B,TRAF2,IL3,GTF2B, Signaling (98%) SUMO1,POLR2J 32 Gap Junction Signaling 1,07E00 2,68E-02 4/149 (3%) 145/149 TUBA1B,TUBA3C/TUBA3 (97%) D,PLCG1,PRKD1 33 Salvage Pathways of 1,07E00 1,25E-01 1/8 (13%) 7/8 (88%) APOBEC3B Pyrimidine Deoxyribonucleotides 34 MSP-RON Signaling Pathway 1,03E00 4,35E-02 2/46 (4%) 44/46 (96%) F12,IL3

35 Assembly of RNA Polymerase 1,02E00 1,11E-01 1/9 (11%) 8/9 (89%) UBTF I Complex 36 UDP-N-acetyl-D- 1,02E00 1,11E-01 1/9 (11%) 8/9 (89%) GNPDA1 galactosamine Biosynthesis II

37 TNFR1 Signaling 1,02E00 4,26E-02 2/47 (4%) 45/47 (96%) MAP4K2,TRAF2

38 Dopamine-DARPP32 1,01E00 2,55E-02 4/157 (3%) 153/157 PPP1R3D,KCNJ1,PLCG1,P Feedback in cAMP Signaling (97%) RKD1

39 Neuropathic Pain Signaling In 1,01E00 3,03E-02 3/99 (3%) 96/99 (97%) KCNN3,PLCG1,PRKD1 Dorsal Horn Neurons

40 Role of NFAT in Regulation of 9,95E-01 2,52E-02 4/159 (3%) 155/159 GNA11,PLCG1,IKBKAP,H2 the Immune Response (97%) BFM

41 Histidine Degradation VI 9,76E-01 1E-01 1/10 (10%) 9/10 (90%) MICAL2 42 CD27 Signaling in 9,59E-01 3,92E-02 2/51 (4%) 49/51 (96%) TRAF2,IKBKAP Lymphocytes 43 Fc Epsilon RI Signaling 9,52E-01 2,86E-02 3/105 (3%) 102/105 IL3,PLCG1,PRKD1 (97%) 44 Corticotropin Releasing 9,52E-01 2,86E-02 3/105 (3%) 102/105 PLCG1,PTCH2,PRKD1 Hormone Signaling (97%) 45 Calcium-induced T 9,31E-01 3,77E-02 2/53 (4%) 51/53 (96%) PLCG1,PRKD1 Lymphocyte Apoptosis 46 Lymphotoxin β Receptor 9,18E-01 3,7E-02 2/54 (4%) 52/54 (96%) TRAF2,IKBKAP Signaling 47 Thrombopoietin Signaling 9,05E-01 3,64E-02 2/55 (4%) 53/55 (96%) PLCG1,PRKD1

48 Assembly of RNA Polymerase 9,02E-01 8,33E-02 1/12 (8%) 11/12 (92%) GTF3C1 III Complex 49 Hematopoiesis from 9,02E-01 8,33E-02 1/12 (8%) 11/12 (92%) IL3 Multipotent Stem Cells 50 Ubiquinol-10 Biosynthesis 9,02E-01 8,33E-02 1/12 (8%) 11/12 (92%) MICAL2 (Eukaryotic) 51 ErbB4 Signaling 8,68E-01 3,45E-02 2/58 (3%) 56/58 (97%) PLCG1,PRKD1

52 Induction of Apoptosis by 8,56E-01 3,39E-02 2/59 (3%) 57/59 (97%) TRAF2,IKBKAP HIV1 53 DNA Double-Strand Break 8,39E-01 7,14E-02 1/14 (7%) 13/14 (93%) MRE11A Repair by Homologous Recombination 54 DNA Double-Strand Break 8,39E-01 7,14E-02 1/14 (7%) 13/14 (93%) MRE11A Repair by Non-Homologous End Joining 55 Colanic Acid Building Blocks 8,39E-01 7,14E-02 1/14 (7%) 13/14 (93%) GMDS Biosynthesis 56 T Helper Cell Differentiation 8,21E-01 3,23E-02 2/62 (3%) 60/62 (97%) CD40LG,IL12RB1

57 Telomere Extension by 8,12E-01 6,67E-02 1/15 (7%) 14/15 (93%) MRE11A Telomerase 58 CCR5 Signaling in 8,1E-01 3,17E-02 2/63 (3%) 61/63 (97%) PLCG1,PRKD1 Macrophages 59 Hypoxia Signaling in the 8,1E-01 3,17E-02 2/63 (3%) 61/63 (97%) SUMO1,UBE2G1 Cardiovascular System 60 Thrombin Signaling 8,1E-01 2,14E-02 4/187 (2%) 183/187 GNA11,PLCG1,MYLK,PRK (98%) D1 61 Remodeling of Epithelial 7,99E-01 3,12E-02 2/64 (3%) 62/64 (97%) TUBA1B,TUBA3C/TUBA3 Adherens Junctions D 62 Angiopoietin Signaling 7,89E-01 3,08E-02 2/65 (3%) 63/65 (97%) IKBKAP,TEK

63 Extrinsic Prothrombin 7,86E-01 6,25E-02 1/16 (6%) 15/16 (94%) F12 Activation Pathway 64 Estrogen Receptor Signaling 7,83E-01 2,38E-02 3/126 (2%) 123/126 TAF4B,GTF2B,POLR2J (98%) 65 IL-15 Signaling 7,79E-01 3,03E-02 2/66 (3%) 64/66 (97%) TRAF2,PLCG1

66 Erythropoietin Signaling 7,68E-01 2,99E-02 2/67 (3%) 65/67 (97%) PLCG1,PRKD1

67 γ-linolenate Biosynthesis II 7,62E-01 5,88E-02 1/17 (6%) 16/17 (94%) CYB5R3 (Animals) 68 Melatonin Signaling 7,58E-01 2,94E-02 2/68 (3%) 66/68 (97%) PLCG1,PRKD1

69 Macropinocytosis Signaling 7,58E-01 2,94E-02 2/68 (3%) 66/68 (97%) PLCG1,PRKD1

70 Growth Hormone Signaling 7,49E-01 2,9E-02 2/69 (3%) 67/69 (97%) PLCG1,PRKD1

71 IL-12 Signaling and 7,48E-01 2,29E-02 3/131 (2%) 128/131 CD40LG,IL12RB1,PRKD1 Production in Macrophages (98%)

72 Relaxin Signaling 7,42E-01 2,27E-02 3/132 (2%) 129/132 ENPP6,GNA11,PDE5A (98%) 73 Cardiac β-adrenergic 7,42E-01 2,27E-02 3/132 (2%) 129/132 ENPP6,PPP1R3D,PDE5A Signaling (98%) 74 Differential Regulation of 7,4E-01 5,56E-02 1/18 (6%) 17/18 (94%) IL3 Cytokine Production in Macrophages and T Helper Cells by IL-17A and IL-17F

75 TREM1 Signaling 7,39E-01 2,86E-02 2/70 (3%) 68/70 (97%) NLRP3,PLCG1 76 GPCR-Mediated Integration 7,39E-01 2,86E-02 2/70 (3%) 68/70 (97%) GNA11,PLCG1 of Enteroendocrine Signaling Exemplified by an L Cell

77 Synaptic Long Term 7,35E-01 2,26E-02 3/133 (2%) 130/133 GNA11,PLCG1,PRKD1 Depression (98%) 78 IL-3 Signaling 7,3E-01 2,82E-02 2/71 (3%) 69/71 (97%) IL3,PRKD1

79 Small Cell Lung Cancer 7,3E-01 2,82E-02 2/71 (3%) 69/71 (97%) TRAF2,CCNE2 Signaling 80 Communication between 7,2E-01 2,78E-02 2/72 (3%) 70/72 (97%) IL3,CD40LG Innate and Adaptive Immune Cells 81 GADD45 Signaling 7,18E-01 5,26E-02 1/19 (5%) 18/19 (95%) CCNE2

82 DNA damage-induced 14-3- 7,18E-01 5,26E-02 1/19 (5%) 18/19 (95%) CCNE2 3σ Signaling 83 Prolactin Signaling 7,11E-01 2,74E-02 2/73 (3%) 71/73 (97%) PLCG1,PRKD1

84 VEGF Family Ligand-Receptor 7,02E-01 2,7E-02 2/74 (3%) 72/74 (97%) PLCG1,PRKD1 Interactions 85 Endoplasmic Reticulum 6,8E-01 4,76E-02 1/21 (5%) 20/21 (95%) TRAF2 Stress Pathway 86 VDR/RXR Activation 6,77E-01 2,6E-02 2/77 (3%) 75/77 (97%) GTF2B,PRKD1 87 Gαq Signaling 6,61E-01 2,07E-02 3/145 (2%) 142/145 GNA11,PLCG1,PRKD1 (98%) 88 Differential Regulation of 6,45E-01 4,35E-02 1/23 (4%) 22/23 (96%) IL3 Cytokine Production in Intestinal Epithelial Cells by IL-17A and IL-17F 89 TCA Cycle II (Eukaryotic) 6,45E-01 4,35E-02 1/23 (4%) 22/23 (96%) ACO2

90 Tec Kinase Signaling 6,33E-01 2E-02 3/150 (2%) 147/150 GNA11,PLCG1,PRKD1 (98%) 91 CTLA4 Signaling in Cytotoxic 6,29E-01 2,41E-02 2/83 (2%) 81/83 (98%) PLCG1,AP2A2 T Lymphocytes 92 Estrogen-mediated S-phase 6,29E-01 4,17E-02 1/24 (4%) 23/24 (96%) CCNE2 Entry 93 Huntington's Disease 6,19E-01 1,78E-02 4/225 (2%) 221/225 GNA11,POLR2J,AP2A2,P Signaling (98%) RKD1 94 Neuregulin Signaling 6,14E-01 2,35E-02 2/85 (2%) 83/85 (98%) PLCG1,PRKD1

95 α-Adrenergic Signaling 6,14E-01 2,35E-02 2/85 (2%) 83/85 (98%) PLCG1,PRKD1

96 Crosstalk between Dendritic 6,14E-01 2,35E-02 2/85 (2%) 83/85 (98%) IL3,CD40LG Cells and Natural Killer Cells

97 ErbB Signaling 6,14E-01 2,35E-02 2/85 (2%) 83/85 (98%) PLCG1,PRKD1 98 FAK Signaling 6,07E-01 2,33E-02 2/86 (2%) 84/86 (98%) HMMR,PLCG1

99 UVA-Induced MAPK Signaling 5,99E-01 2,3E-02 2/87 (2%) 85/87 (98%) PARP2,PLCG1

100 Antiproliferative Role of TOB 5,98E-01 3,85E-02 1/26 (4%) 25/26 (96%) CCNE2 in T Cell Signaling 101 D-myo-inositol (1,4,5)- 5,98E-01 3,85E-02 1/26 (4%) 25/26 (96%) PLCG1 Trisphosphate Biosynthesis

102 Factors Promoting 5,85E-01 2,25E-02 2/89 (2%) 87/89 (98%) CCNE2,PRKD1 Cardiogenesis in Vertebrates

103 Dendritic Cell Maturation 5,81E-01 1,88E-02 3/160 (2%) 157/160 CD40LG,CD1B,PLCG1 (98%) 104 Granulocyte Adhesion and 5,81E-01 1,88E-02 3/160 (2%) 157/160 CD99,SELL,CCL18 Diapedesis (98%) 105 Death Receptor Signaling 5,72E-01 2,2E-02 2/91 (2%) 89/91 (98%) TRAF2,PARP2 106 TNFR2 Signaling 5,71E-01 3,57E-02 1/28 (4%) 27/28 (96%) TRAF2

107 Intrinsic Prothrombin 5,71E-01 3,57E-02 1/28 (4%) 27/28 (96%) F12 Activation Pathway 108 Fcγ Receptor-mediated 5,65E-01 2,17E-02 2/92 (2%) 90/92 (98%) PLCG1,PRKD1 Phagocytosis in Macrophages and Monocytes 109 Role of p14/p19ARF in 5,58E-01 3,45E-02 1/29 (3%) 28/29 (97%) UBTF Tumor Suppression 110 Sonic Hedgehog Signaling 5,58E-01 3,45E-02 1/29 (3%) 28/29 (97%) PTCH2

111 PPARα/RXRα Activation 5,57E-01 1,82E-02 3/165 (2%) 162/165 GNA11,PLCG1,AP2A2 (98%) 112 Endothelin-1 Signaling 5,57E-01 1,82E-02 3/165 (2%) 162/165 GNA11,PLCG1,PRKD1 (98%) 113 Wnt/β-catenin Signaling 5,57E-01 1,82E-02 3/165 (2%) 162/165 NR5A2,MAP4K1,H2BFM (98%) 114 Glioma Signaling 5,52E-01 2,13E-02 2/94 (2%) 92/94 (98%) PLCG1,PRKD1

115 Nitric Oxide Signaling in the 5,46E-01 2,11E-02 2/95 (2%) 93/95 (98%) PDE5A,PRKD1 Cardiovascular System

116 Sertoli Cell-Sertoli Cell 5,38E-01 1,78E-02 3/169 (2%) 166/169 TUBA1B,TUBA3C/TUBA3 Junction Signaling (98%) D,H2BFM 117 Agranulocyte Adhesion and 5,34E-01 1,76E-02 3/170 (2%) 167/170 CD99,SELL,CCL18 Diapedesis (98%) 118 G Protein Signaling Mediated 5,33E-01 3,23E-02 1/31 (3%) 30/31 (97%) PLCG1 by Tubby 119 CDK5 Signaling 5,27E-01 2,04E-02 2/98 (2%) 96/98 (98%) LAMC1,PPP1R3D

120 iCOS-iCOSL Signaling in T 5,27E-01 2,04E-02 2/98 (2%) 96/98 (98%) CD40LG,PLCG1 Helper Cells 121 phagosome formation 5,22E-01 2,02E-02 2/99 (2%) 97/99 (98%) PLCG1,PRKD1

122 Protein Ubiquitination 5,17E-01 1,59E-02 4/251 (2%) 247/251 PSMB3,USP12,UBE2G1,P Pathway (98%) SMD4 123 G-Protein Coupled Receptor 5,17E-01 1,59E-02 4/251 (2%) 247/251 ENPP6,GNA11,PDE5A,AD Signaling (98%) ORA3 124 Hematopoiesis from 5,11E-01 3,03E-02 1/33 (3%) 32/33 (97%) IL3 Pluripotent Stem Cells 125 Systemic Lupus 5,03E-01 1,69E-02 3/177 (2%) 174/177 CD40LG,PLCG1,LSM4 Erythematosus Signaling (98%) 126 Oncostatin M Signaling 5E-01 2,94E-02 1/34 (3%) 33/34 (97%) EPAS1

127 Autoimmune Thyroid 5E-01 2,94E-02 1/34 (3%) 33/34 (97%) CD40LG Disease Signaling 128 Production of Nitric Oxide 4,95E-01 1,68E-02 3/179 (2%) 176/179 PPP1R3D,PLCG1,PRKD1 and Reactive Oxygen Species (98%) in Macrophages

129 HGF Signaling 4,93E-01 1,92E-02 2/104 (2%) 102/104 PLCG1,PRKD1 (98%) 130 Coagulation System 4,9E-01 2,86E-02 1/35 (3%) 34/35 (97%) F12

131 Cell Cycle Regulation by BTG 4,9E-01 2,86E-02 1/35 (3%) 34/35 (97%) CCNE2 Family Proteins 132 Nucleotide Excision Repair 4,9E-01 2,86E-02 1/35 (3%) 34/35 (97%) POLR2J Pathway 133 Natural Killer Cell Signaling 4,88E-01 1,9E-02 2/105 (2%) 103/105 PLCG1,PRKD1 (98%) 134 Axonal Guidance Signaling 4,87E-01 1,43E-02 6/421 (1%) 415/421 TUBA1B,GNA11,TUBA3C (99%) /TUBA3D,PLCG1,PTCH2, PRKD1 135 Sphingosine-1-phosphate 4,82E-01 1,89E-02 2/106 (2%) 104/106 PLCG1,ASAH1 Signaling (98%) 136 Complement System 4,8E-01 2,78E-02 1/36 (3%) 35/36 (97%) CR2

137 IL-8 Signaling 4,79E-01 1,64E-02 3/183 (2%) 180/183 TEK,PRKD1,CR2 (98%) 138 Renin-Angiotensin Signaling 4,72E-01 1,85E-02 2/108 (2%) 106/108 PLCG1,PRKD1 (98%) 139 Allograft Rejection Signaling 4,7E-01 2,7E-02 1/37 (3%) 36/37 (97%) CD40LG

140 Sperm Motility 4,66E-01 1,83E-02 2/109 (2%) 107/109 PLCG1,PRKD1 (98%) 141 Gustation Pathway 4,66E-01 1,83E-02 2/109 (2%) 107/109 ENPP6,PDE5A (98%) 142 April Mediated Signaling 4,61E-01 2,63E-02 1/38 (3%) 37/38 (97%) TRAF2

143 CCR3 Signaling in Eosinophils 4,56E-01 1,8E-02 2/111 (2%) 109/111 MYLK,PRKD1 (98%) 144 Docosahexaenoic Acid (DHA) 4,52E-01 2,56E-02 1/39 (3%) 38/39 (97%) H2BFM Signaling 145 Primary Immunodeficiency 4,52E-01 2,56E-02 1/39 (3%) 38/39 (97%) CD40LG Signaling

146 Type II Diabetes Mellitus 4,51E-01 1,79E-02 2/112 (2%) 110/112 TRAF2,PRKD1 Signaling (98%) 147 p38 MAPK Signaling 4,51E-01 1,79E-02 2/112 (2%) 110/112 TRAF2,MAP4K1 (98%) 148 Leukocyte Extravasation 4,48E-01 1,57E-02 3/191 (2%) 188/191 CD99,PLCG1,PRKD1 Signaling (98%) 149 Role of PKR in Interferon 4,43E-01 2,5E-02 1/40 (3%) 39/40 (98%) TRAF2 Induction and Antiviral Response 150 phagosome maturation 4,42E-01 1,75E-02 2/114 (2%) 112/114 TUBA1B,TUBA3C/TUBA3 (98%) D 151 Molecular Mechanisms of 4,36E-01 1,4E-02 5/358 (1%) 353/358 CCNE2,GNA11,H2BFM,PT Cancer (99%) CH2,PRKD1 152 Role of RIG1-like Receptors 4,35E-01 2,44E-02 1/41 (2%) 40/41 (98%) TRAF2 in Antiviral Innate Immunity

153 Mechanisms of Viral Exit 4,35E-01 2,44E-02 1/41 (2%) 40/41 (98%) PRKD1 from Host Cells 154 Role of 4,35E-01 2,44E-02 1/41 (2%) 40/41 (98%) IFNL1 Hypercytokinemia/hyperche mokinemia in the Pathogenesis of Influenza

155 IL-6 Signaling 4,32E-01 1,72E-02 2/116 (2%) 114/116 TRAF2,TNFAIP6 (98%) 156 UVC-Induced MAPK Signaling 4,26E-01 2,38E-02 1/42 (2%) 41/42 (98%) PRKD1

157 HMGB1 Signaling 4,23E-01 1,69E-02 2/118 (2%) 116/118 IL3,IL25 (98%) 158 p70S6K Signaling 4,23E-01 1,69E-02 2/118 (2%) 116/118 PLCG1,PRKD1 (98%) 159 P2Y Purigenic Receptor 4,23E-01 1,69E-02 2/118 (2%) 116/118 PLCG1,PRKD1 Signaling Pathway (98%) 160 LXR/RXR Activation 4,14E-01 1,67E-02 2/120 (2%) 118/120 HPX,NR1H2 (98%) 161 Cdc42 Signaling 4,09E-01 1,65E-02 2/121 (2%) 119/121 MYLK,IQGAP3 (98%) 162 Role of Oct4 in Mammalian 4,03E-01 2,22E-02 1/45 (2%) 44/45 (98%) NR5A2 Embryonic Stem Cell Pluripotency 163 LPS/IL-1 Mediated Inhibition 4,03E-01 1,47E-02 3/204 (1%) 201/204 TRAF2,NR1H2,NR5A2 of RXR Function (99%)

164 PI3K Signaling in B 4,01E-01 1,63E-02 2/123 (2%) 121/123 PLCG1,CR2 Lymphocytes (98%) 165 FXR/RXR Activation 3,97E-01 1,61E-02 2/124 (2%) 122/124 HPX,NR5A2 (98%) 166 OX40 Signaling Pathway 3,96E-01 2,17E-02 1/46 (2%) 45/46 (98%) TRAF2

167 nNOS Signaling in Neurons 3,96E-01 2,17E-02 1/46 (2%) 45/46 (98%) PRKD1

168 Hereditary Breast Cancer 3,88E-01 1,59E-02 2/126 (2%) 124/126 POLR2J,MRE11A Signaling (98%) 169 GNRH Signaling 3,84E-01 1,57E-02 2/127 (2%) 125/127 GNA11,PRKD1 (98%) 170 Insulin Receptor Signaling 3,84E-01 1,57E-02 2/127 (2%) 125/127 PPP1R3D,H2BFM (98%) 171 cAMP-mediated signaling 3,78E-01 1,42E-02 3/212 (1%) 209/212 ENPP6,PDE5A,ADORA3 (99%) 172 eNOS Signaling 3,57E-01 1,49E-02 2/134 (1%) 132/134 PLCG1,PRKD1 (99%) 173 Phospholipases 3,56E-01 1,92E-02 1/52 (2%) 51/52 (98%) PLCG1

174 UVB-Induced MAPK Signaling 3,56E-01 1,92E-02 1/52 (2%) 51/52 (98%) PRKD1

175 Unfolded protein response 3,5E-01 1,89E-02 1/53 (2%) 52/53 (98%) TRAF2

176 Role of CHK Proteins in Cell 3,38E-01 1,82E-02 1/55 (2%) 54/55 (98%) MRE11A Cycle Checkpoint Control

177 Wnt/Ca+ pathway 3,38E-01 1,82E-02 1/55 (2%) 54/55 (98%) PLCG1

178 ErbB2-ErbB3 Signaling 3,32E-01 1,79E-02 1/56 (2%) 55/56 (98%) H2BFM

179 EGF Signaling 3,32E-01 1,79E-02 1/56 (2%) 55/56 (98%) PLCG1

180 Epithelial Adherens Junction 3,32E-01 1,42E-02 2/141 (1%) 139/141 TUBA1B,TUBA3C/TUBA3 Signaling (99%) D 181 Glioma Invasiveness 3,27E-01 1,75E-02 1/57 (2%) 56/57 (98%) HMMR Signaling 182 Retinoic acid Mediated 3,21E-01 1,72E-02 1/58 (2%) 57/58 (98%) PARP2 Apoptosis Signaling 183 ATM Signaling 3,16E-01 1,69E-02 1/59 (2%) 58/59 (98%) MRE11A

184 Activation of IRF by Cytosolic 3,11E-01 1,67E-02 1/60 (2%) 59/60 (98%) IKBKAP Pattern Recognition Receptors 185 Aldosterone Signaling in 3,03E-01 1,33E-02 2/150 (1%) 148/150 PLCG1,PRKD1 Epithelial Cells (99%) 186 CXCR4 Signaling 3E-01 1,32E-02 2/151 (1%) 149/151 GNA11,PRKD1 (99%) 187 Cell Cycle: G1/S Checkpoint 2,96E-01 1,59E-02 1/63 (2%) 62/63 (98%) CCNE2 Regulation 188 Germ Cell-Sertoli Cell 2,91E-01 1,3E-02 2/154 (1%) 152/154 TUBA1B,TUBA3C/TUBA3 Junction Signaling (99%) D 189 Non-Small Cell Lung Cancer 2,87E-01 1,54E-02 1/65 (2%) 64/65 (98%) PLCG1 Signaling 190 Agrin Interactions at 2,78E-01 1,49E-02 1/67 (1%) 66/67 (99%) LAMC1 Neuromuscular Junction 191 Neurotrophin/TRK Signaling 2,78E-01 1,49E-02 1/67 (1%) 66/67 (99%) PLCG1

192 Mitochondrial Dysfunction 2,76E-01 1,26E-02 2/159 (1%) 157/159 ACO2,CYB5R3 (99%) 193 Basal Cell Carcinoma 2,74E-01 1,47E-02 1/68 (1%) 67/68 (99%) PTCH2 Signaling 194 GDNF Family Ligand- 2,74E-01 1,47E-02 1/68 (1%) 67/68 (99%) PLCG1 Receptor Interactions 195 Chemokine Signaling 2,74E-01 1,47E-02 1/68 (1%) 67/68 (99%) PLCG1

196 Renal Cell Carcinoma 2,69E-01 1,45E-02 1/69 (1%) 68/69 (99%) EGLN3 Signaling 197 Caveolar-mediated 2,61E-01 1,41E-02 1/71 (1%) 70/71 (99%) COPZ1 Endocytosis Signaling 198 NF-κB Signaling 2,6E-01 1,21E-02 2/165 (1%) 163/165 TRAF2,CD40LG (99%) 199 Acute Phase Response 2,58E-01 1,2E-02 2/166 (1%) 164/166 TRAF2,HPX Signaling (99%) 200 LPS-stimulated MAPK 2,53E-01 1,37E-02 1/73 (1%) 72/73 (99%) PRKD1 Signaling 201 Leptin Signaling in Obesity 2,53E-01 1,37E-02 1/73 (1%) 72/73 (99%) PLCG1

202 Ephrin B Signaling 2,53E-01 1,37E-02 1/73 (1%) 72/73 (99%) GNA11

203 Altered T Cell and B Cell 2,42E-01 1,32E-02 1/76 (1%) 75/76 (99%) CD40LG Signaling in Rheumatoid Arthritis 204 Regulation of IL-2 Expression 2,42E-01 1,32E-02 1/76 (1%) 75/76 (99%) PLCG1 in Activated and Anergic T Lymphocytes

205 Role of BRCA1 in DNA 2,38E-01 1,3E-02 1/77 (1%) 76/77 (99%) MRE11A Damage Response 206 Cyclins and Cell Cycle 2,38E-01 1,3E-02 1/77 (1%) 76/77 (99%) CCNE2 Regulation 207 Dopamine Receptor 2,38E-01 1,3E-02 1/77 (1%) 76/77 (99%) PPP1R3D Signaling 208 PDGF Signaling 2,38E-01 1,3E-02 1/77 (1%) 76/77 (99%) PLCG1 209 Role of NFAT in Cardiac 2,38E-01 1,15E-02 2/174 (1%) 172/174 PLCG1,PRKD1 Hypertrophy (99%) 210 Reelin Signaling in Neurons 2,31E-01 1,27E-02 1/79 (1%) 78/79 (99%) MAP4K1

211 Prostate Cancer Signaling 2,28E-01 1,25E-02 1/80 (1%) 79/80 (99%) CCNE2

212 Melanocyte Development 2,15E-01 1,19E-02 1/84 (1%) 83/84 (99%) PLCG1 and Pigmentation Signaling 213 TR/RXR Activation 2,12E-01 1,18E-02 1/85 (1%) 84/85 (99%) SLC16A3

214 HIPPO signaling 2,12E-01 1,18E-02 1/85 (1%) 84/85 (99%) PPP1R3D

215 FGF Signaling 2,12E-01 1,18E-02 1/85 (1%) 84/85 (99%) PLCG1

216 Regulation of Actin-based 2,09E-01 1,16E-02 1/86 (1%) 85/86 (99%) MYLK Motility by Rho 217 RANK Signaling in 2,09E-01 1,16E-02 1/86 (1%) 85/86 (99%) TRAF2 Osteoclasts 218 TGF-β Signaling 2,06E-01 1,15E-02 1/87 (1%) 86/87 (99%) MAP4K1

219 PAK Signaling 2,03E-01 1,14E-02 1/88 (1%) 87/88 (99%) MYLK

220 Apoptosis Signaling 2,03E-01 1,14E-02 1/88 (1%) 87/88 (99%) PLCG1

221 VEGF Signaling 2E-01 1,12E-02 1/89 (1%) 88/89 (99%) PLCG1

222 PPAR Signaling 1,97E-01 1,11E-02 1/90 (1%) 89/90 (99%) TRAF2