Cytotoxic, Antimicrobial, Antioxidant, Antilipoxygenase
South African Journal of Botany 95 (2014) 9–18 Contents lists available at ScienceDirect South African Journal of Botany journal homepage: www.elsevier.com/locate/sajb Cytotoxic, antimicrobial, antioxidant, antilipoxygenase activities and phenolic composition of Ozoroa and Searsia species (Anacardiaceae) used in South African traditional medicine for treating diarrhoea Aroke S. Ahmed a,b,⁎,LyndyJ.McGawa, Nivan Moodley c, Vinasan Naidoo a, Jacobus N. Eloff a a Phytomedicine programme, Department of Paraclinical Sciences, Faculty of Veterinary Science, University of Pretoria, Private Bag X04, Onderstepoort 0110, South Africa b Federal Institute of Industrial Research, Oshodi, PMB 21023, Ikeja, Lagos, Nigeria c Biosciences, Council for Scientific and Industrial Research, P.O. Box 395, Pretoria 0001, South Africa article info abstract Article history: The safety and effectiveness of many of the medicinal plants used in traditional medicine by rural people with Received 15 November 2013 little or no access to allopathic drugs is yet to be evaluated. With this in mind, Ozoroa and Searsia (previously Received in revised form 27 June 2014 known as Rhus) species traditionally used in South Africa to treat microbial infections and gastrointestinal Accepted 29 July 2014 disorders were selected for in vitro evaluation of biological activities and cytotoxicity. Available online xxxx Phenolic-enriched leaf extracts were prepared using mixture of 1% HCl acidified 70% acetone and n-hexane. The Edited by J Van Staden crude extract was further fractionated with solvent of different polarities. Crude extracts and fractions were test- ed against Staphylococcus aureus, Pseudomonas aeruginosa, Escherichia coli, Enterococcus faecalis, Aspergillus Keywords: fumigatus, Candida albicans and Cryptococcus neoformans.
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