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The Nuffield Department of CLINICAL Medicine Endeavour, Discover, Inspire the Nuffield Department of CLINICAL Medicine ENDEAVOUR, DISCOVER, INSPIRE

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The Nuffield Department of CLINICAL Medicine Endeavour, Discover, Inspire the Nuffield Department of CLINICAL Medicine ENDEAVOUR, DISCOVER, INSPIRE THE NUFFIELD DEPARTMENT of CLINICAL MEDICINE Endeavour, Discover, Inspire THE NUFFIELD DEPARTMENT OF CLINICAL MEDICINE ENDEAVOUR, DISCOVER, INSPIRE 1 THE NUFFIELD DEPARTMENT OF CLINICAL MEDICINE ENDEAVOUR, DISCOVER, INSPIRE “In clinical medicine, if one doesn’t know what to do, one would be better to do nothing. 2 THE NUFFIELD DEPARTMENT OF CLINICAL MEDICINE ENDEAVOUR, DISCOVER, INSPIRE In the laboratory, precisely the reverse is true, if you don’t know what to do, you would be better off doing something. Professor Sir Peter Ratcliffe FRS 3 THE NUFFIELD DEPARTMENT OF CLINICAL MEDICINE ENDEAVOUR, DISCOVER, INSPIRE 4 THE NUFFIELD DEPARTMENT OF CLINICAL MEDICINE ENDEAVOUR, DISCOVER, INSPIRE Endeavour Discover Inspire Pronunciation: Pronunciation: Pronunciation: ӏn'dєvә /dӏ'skлvә/ /ӏn'spлӏә/ verb verb verb [no object, with infinitive] [with object] [with object] try hard to do or achieve be the first to find fill (someone) with the something: or observe (a place, urge or ability to do or She is endeavouring to help substance, or scientific feel something, especially the Developing World phenomenon): to do something creative: Fleming discovered penicillin his philosophy inspired early in the twentieth a later generation of century environmentalists © Oxford Dictionary, Oxford University Press This review undertakes to demonstrate the application of the Nuffield Department of Clinical Medicine’s core tenets of endeavor, discover, inspire. It includes several groups, units and centres that, driven by the science, have recently joined other elements of the Medical Sciences Division to create the Radcliffe Department of Medicine and the Nuffield Department of Population Health. Whilst formally known as the Nuffield Department of Clinical Medicine, to ensure its endeavours in clinical and basic science are equally conveyed, the Department is commonly referred to as the Nuffield Department of Medicine (NDM). 5 THE NUFFIELD DEPARTMENT OF CLINICAL MEDICINE ENDEAVOUR, DISCOVER, INSPIRE THE NUFFIELD DEPARTMENT of CLINICAL MEDICINE Endeavour, Discover, Inspire 6 THE NUFFIELD DEPARTMENT OF CLINICAL MEDICINE ENDEAVOUR, DISCOVER, INSPIRE Contents 8 Foreword from Professor Sir 36 Professor Helen McShane Peter Ratcliffe FRS 38 Professor Rodney Phillips 9 Message from Associate Head of 40 Professor Fiona Powrie FRS Department, Mr Darren Nash 42 Professor Sir Peter Ratcliffe FRS Comments from: Regius Professor of Medicine, Head of Medical Sciences 44 Professor Sarah Rowland-Jones Division 46 Professor David Stuart FRS 10 i Department and Research 48 Professor Nick White OBE FRS 12 An Introduction 50 Global Research Activity 16 Professor Chas Bountra 52 Infrastructure and support 18 Professor Sir Rory Collins 54 ii Students 20 Professor Peter Donnelly FRS 60 iii Activities 22 Professor Sarah Gilbert 62 Outreach and Impact 24 Professor Adrian Hill 64 Clinical Care 26 Professor Rury Holman 66 Environment 28 Professor Yvonne Jones 68 The NDM in Oxford 30 Professor Dominic Kwiatkowski 70 iv Appendix 32 Professor Xin Lu 76 Index 34 Professor Sir Andrew McMichael FRS 7 THE NUFFIELD DEPARTMENT OF CLINICAL MEDICINE ENDEAVOUR, DISCOVER, INSPIRE A message from the Nuffield Professor of Clinical Medicine It is an exhilarating time to be working in medical science. We are witnessing a golden age in genetics, a new era in target drug discovery, and an unprecedented number of collaborations between research institutes and the pharmaceutical industry. As one of the largest medical research departments in Europe, the Nuffield Department of Medicine (NDM) is fast becoming a world leader in medical science. The wide range of research fields we support, our multi-disciplinary, multi-institutional approach, industrial and pharmaceutical collaborations, and our world-leading infrastructure, all pave the way for a flourishing future, both here in Oxford and abroad. As a clinician, I am a great supporter of the bench to bedside research philosophy. The Department's significant achievements in the laboratory and in the clinic have been made possible through our provision of an open access environment, which encourages, supports and inspires our scientists to achieve the best academic and clinical outcomes. However, what really sets NDM apart is its commitment to the development of innovative infrastructure. The infrastructure we have established in Oxford, Africa and Southeast Asia over the past decade allows our scientists to come together around the world to formulate ideas, collaborate, “As one of the largest share resources, and take risks. This is the key to groundbreaking medical research multidisciplinary research. As the Nuffield Professor of Medicine, I am committed to ensuring departments in Europe, the Department remains a major contributor to medical research worldwide, for the advancement of science and medicine, and the the Nuffield Department improvement of individual lives on a global scale. of Medicine is fast becoming a world leader Professor Sir Peter Ratcliffe FRS in medical science.” 8 THE NUFFIELD DEPARTMENT OF CLINICAL MEDICINE ENDEAVOUR, DISCOVER, INSPIRE For many years the NDM has led A message from the way in immunology, tropical the Associate Head of Department medicine, structural biology, and human genetics. Prior to my (Academic Support and Finance) appointment as the Nuffield Professor of Medicine, NDM had forged strong clinical links – in taking the Department forward, it was clear to me that the establishment of multidisciplinary institutes would provide a solid foundation for scientific growth. Peter has embraced this vision and continues to build on it for the improvement of the Department’s outputs and its overall clinical impact. Regius Professor Sir John Bell FRS Academic support within such a vibrant and energetic Department is a challenge, one that the Department support staff and the Central University have risen to exceptionally. The NDM is unique in that it Growth over the last decade has been exponential. We have seen a dedicated group is a clinical department with of business managers emerge, whose roles have changed from that of scorekeepers very powerful basic science and guardians, to academic advocates and business partners. The trust placed in infrastructure and goes from these staff and their teams – to help enable and support an environment that serves fundamental discovery all the the needs of our academic community – is well placed. way through to application in The NDM is a confident organisation, which promotes a style of governance that the wards and clinics of our fully enables academic freedom, in both local management and in setting strategic hospitals. The Department is at aims and goals at a unit, centre and institute level. It manages to achieve this whilst still embracing the tenets of collaborative research and the overarching purpose and the heart of the Medical Sciences strategy of the Department. Division at Oxford. With facilitation in mind we attempt to always alleviate the administrative burden Head of the Medical on academic staff, and we try to keep decision making and resources as close to Sciences Division, the laboratory bench as possible. The positive results of this approach to supporting Professor Alastair scientists can be attested to by the impacts highlighted throughout this book. Buchan FMedSci Darren Nash MBA BSc (Hons) 9 THE NUFFIELD DEPARTMENT OF CLINICAL MEDICINE ENDEAVOUR, DISCOVER, INSPIRE 10 THE NUFFIELD DEPARTMENT OF CLINICAL MEDICINE ENDEAVOUR, DISCOVER, INSPIRE i Department AND RESEARCH 11 THE NUFFIELD DEPARTMENT OF CLINICAL MEDICINE ENDEAVOUR, DISCOVER, INSPIRE Led by Professor Sir Peter Ratcliffe FRS, The Nuffield Department of who is both an active researcher in cell biology and a practicing clinician, the NDM is committed to fostering research that moves Medicine is one of the largest beyond academia, from bench to bedside. The Department is structured around and most highly regarded several substantially autonomous sub- divisions, in Oxford and abroad. These clinical medicine institutes, centres and units are departments of medicine supported by a central administrative team, NDM Strategic. in Europe. The motivation In Oxford, the NDM is based across multiple local sites, including the John Radcliffe and Churchill Hospitals, and the behind all research carried out University of Oxford’s Old Road Campus – one of the largest centres for biomedical by the NDM has been, and research in Europe. The Department maintains research platforms across a number of disciplines continues to be, the pursuit including: cellular and molecular physiology, structural biology, structural of academic excellence and a genomics, human genomics, cancer research, experimental medicine, vaccine development, clinical biomanufacturing, positive impact on the health epidemiology, clinical trials, and tropical medicine and global health. and wellbeing of the global Allied to UK based research in tropical medicine and global health, the Department operates major research programmes community. overseas too, with research units in Thailand, Laos, Vietnam and Kenya supporting activities at numerous sites in South East Asia and Sub-Saharan Africa. It also operates extensive epidemiological and clinical trial networks throughout China, India and South America. Diverse research platforms within the NDM, both in Oxford and abroad, have significantly contributed to the depth and breadth of the Department’s medical research outputs. Over the past 20 years the NDM has had a profound impact on World Health Organization
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