(12) United States Patent (10) Patent No.: US 9.226,996 B2 Moro Et Al
USOO922.6996B2 (12) United States Patent (10) Patent No.: US 9.226,996 B2 Moro et al. (45) Date of Patent: Jan. 5, 2016 (54) EMULSIONS OR MICROEMULSIONS FOR FOREIGN PATENT DOCUMENTS USE IN ENDOSCOPCMUCOSAL f EP 2494.957 A1 9, 2012 WO OO,78301 A1 12/2000 WO 2009,070793 A1 6, 2009 (71) Applicant: COSMO TECHNOLOGIES LTD., WO 2011, 103245 A1 8, 2011 Dublin (IE) OTHER PUBLICATIONS (72) Inventors: ongo,s Moro, Lainate Lainate (IT); Enrico(IT): Luigi Frimonti, Maria Polymeros, D. et al., “Comparative Performance of Novel Solutions Lainate (IT); Alessandro Repici, Turin for Submucosal Injection in Porcine Stomachs: An Ex Vivo Study.” (IT) s s Digestive and Liver Disease, 2010, vol. 42, pp. 226-229. Jeppsson, R. et al., “The Influence of Emulsifying Agents and of (73) Assignee: COSMO TECHNOLOGIES LTD., Lipid Soluable Drugs on the Fractional Removal Rate of Lipid Emul Dublin (IE) sions from the Blood Stream of the Rabbit.” Acta Pharmacol. et Toxicol., 1975, vol. 37, 134-144. (*) Notice: Subject to any disclaimer, the term of this Fernandez-Esparrach, G. et al., Efficacy of a Reverse-Phase Poly atent is extended or adjusted under 35 mer as a Submucosal Injection Solution for EMR: A Comparative p Study (with video).” Gastrointestinal Endoscopy, 2009, vol. 69, No. U.S.C. 154(b) by 0 days. 6, pp. 1135-1139 Uraoka, T. et al., “Submucosal Injection Solution for Gastrointestinal (21) Appl. No.: 14/546,925 Tract Endoscopic Mucosal Resection and Endoscopic Submucosal (22) Filed: Nov. 18, 2014 Dissection.” Drug Design, Development and Therapy, 2008, vol. 2, e - V.9 pp.
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