The Many Sides of Systems Immunology

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cell.com/lablinks 8:30 a.m. Opening remarks The Many Sides of 8:40 a.m. Session 1: Immune responses from single cells to repertoires Systems Immunology Functional role of innate immune cell diversity Catherine Blish, Stanford University Friday, September 7, 2018 8:30 a.m.—5:00 p.m. T cell repertoire analysis in health and disease University of California, San Francisco, USA Mark Davis, Stanford University Tracing the development of B cell responses Organizers in humans Jason Cyster, University of California, San Francisco Felix Horns, Stanford University Jacques Deguine, Scientific Editor, Cell Neuro-immune interactions and behavioral Ernesto Andrianantoandro, Scientific Editor, outputs Cell Systems Diana Bautista, University of California, Berkeley 10:20 a.m. Coffee break The immune system has been generally 11:00 a.m. Keynote: Stromal cell biology and approached from a reductive perspective, biomaterial engineering but recently more holistic approaches Melody Swartz, University of Chicago are gaining traction, under the umbrella 12:00 p.m. Lunch (not provided) 1:10 p.m. Session 2: Migration and collaboration in of systems immunology. However, this immune responses broad term still encompasses a variety of Imaging of immune cell development and approaches, ranging from engineering and differentiation Ellen Robey, University of California, Berkeley reconstitution of immune molecules and Immune migration and lymph node signaling, to large-scale approaches for the architecture in B cell responses analysis of immune cells, to the integration Jason Cyster, University of California, San Francisco of the immune system within the organism Stromal immune interactions and its microbes. This LabLinks will bring Shannon Turley, Genentech together these communities in an effort to Single-cell analysis of T cell differentiation develop a cohesive systems-level approach and plasticity Nir Yosef, University of California, Berkeley to immunology. 2:50 p.m. Coffee break 3:20 p.m. Session 3: From biological insights Cell Press LabLinks are free, in-person, one-day to clinical applications of systems symposia organized by scientists and Cell Press immunology editors. Each LabLinks symposium features local and Proteomic analysis of immune cell keynote speakers discussing a unified topic to foster functions interactions between colleagues working on related Nevan Krogan, University of California, San Francisco questions, whether those colleagues are across Cytokine signaling and engineering town, across the street, or across the hall. Chris Garcia, Stanford University Large-scale analysis of immune biomarkers To register, go to in cancer http://www.cell.com/lablinks Matthew Albert, Genentech Registration is FREE (space is limited) Antitumoral immune responses Matthew Spitzer, University of California, San Francisco 5:00 p.m. Closing remarks www.cell.com.

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A Plaidoyer for 'Systems Immunology'
Christophe Benoist A Plaidoyer for ‘Systems Immunology’ Ronald N. Germain Diane Mathis Authors’ address Summary: A complete understanding of the immune system will ulti- Christophe Benoist1, Ronald N. Germain2, Diane mately require an integrated perspective on how genetic and epigenetic Mathis1 entities work together to produce the range of physiologic and patho- 1Section on Immunology and Immunogenetics, logic behaviors characteristic of immune function. The immune network Joslin Diabetes Center, Department of encompasses all of the connections and regulatory associations between Medicine, Brigham and Women’s Hospital, individual cells and the sum of interactions between gene products Harvard Medical School, Boston, MA, USA within a cell. With 30 000+ protein-coding genes in a mammalian 2Lymphocyte Biology Section, Laboratory of genome, further compounded by microRNAs and yet unrecognized Immunology, National Institute of Allergy and layers of genetic controls, connecting the dots of this network is a Infectious Diseases, National Institutes of monumental task. Over the past few years, high-throughput techniques Health, Bethesda, MD, USA have allowed a genome-scale view on cell states and cell- or system-level responses to perturbations. Here, we observe that after an early burst of Correspondence to: enthusiasm, there has developed a distinct resistance to placing a high Christophe Benoist value on global genomic or proteomic analyses. Such reluctance has Department of Medicine affected both the practice and the publication of immunological science, Section on Immunology and Immunogenetics resulting in a substantial impediment to the advances in our understand- Joslin Diabetes Center ing that such large-scale studies could potentially provide. We propose Brigham and Women’s Hospital that distinct standards are needed for validation, evaluation, and visual- Harvard Medical School ization of global analyses, such that in-depth descriptions of cellular One Joslin Place responses may complement the gene/factor-centric approaches currently Boston, MA 02215 in favor.
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